JP2018512041A5 - - Google Patents
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- JP2018512041A5 JP2018512041A5 JP2017534279A JP2017534279A JP2018512041A5 JP 2018512041 A5 JP2018512041 A5 JP 2018512041A5 JP 2017534279 A JP2017534279 A JP 2017534279A JP 2017534279 A JP2017534279 A JP 2017534279A JP 2018512041 A5 JP2018512041 A5 JP 2018512041A5
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- Prior art keywords
- deoxy
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- nucleic acid
- antisense strand
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- 125000003729 nucleotide group Chemical group 0.000 claims 11
- 230000000692 anti-sense effect Effects 0.000 claims 9
- 239000002773 nucleotide Substances 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108091081021 Sense strand Proteins 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 102100030708 GTPase KRas Human genes 0.000 claims 1
- 101000584612 Homo sapiens GTPase KRas Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 125000001921 locked nucleotide group Chemical group 0.000 claims 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014266198 | 2014-12-26 | ||
| JP2014266198 | 2014-12-26 | ||
| US201562184209P | 2015-06-24 | 2015-06-24 | |
| US62/184,209 | 2015-06-24 | ||
| US201562266668P | 2015-12-13 | 2015-12-13 | |
| US62/266,668 | 2015-12-13 | ||
| PCT/US2015/067557 WO2016106402A1 (en) | 2014-12-26 | 2015-12-28 | Rna interference agents for p21 gene modulation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512041A JP2018512041A (ja) | 2018-05-10 |
| JP2018512041A5 true JP2018512041A5 (OSRAM) | 2019-02-14 |
| JP6865169B2 JP6865169B2 (ja) | 2021-04-28 |
Family
ID=56151549
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017534294A Active JP6730285B2 (ja) | 2014-12-26 | 2015-12-28 | Rna干渉組成物及び悪性腫瘍のための方法 |
| JP2017534287A Pending JP2018513669A (ja) | 2014-12-26 | 2015-12-28 | Gst−pi遺伝子調節のためのrna剤 |
| JP2017534274A Pending JP2018513104A (ja) | 2014-12-26 | 2015-12-28 | Hsp47及びp21を標的とするrnai分子による悪性腫瘍の治療用組成物及び方法 |
| JP2017534297A Active JP6457645B2 (ja) | 2014-12-26 | 2015-12-28 | GST−π遺伝子を調節するためのRNA干渉剤 |
| JP2017534275A Pending JP2018512373A (ja) | 2014-12-26 | 2015-12-28 | Kras突然変異に関連する悪性腫瘍に対する治療のための方法及び組成物 |
| JP2017534286A Active JP6793649B2 (ja) | 2014-12-26 | 2015-12-28 | P21遺伝子調節のためのrna剤 |
| JP2017534279A Active JP6865169B2 (ja) | 2014-12-26 | 2015-12-28 | P21遺伝子調節のためのrna干渉剤 |
| JP2021183788A Active JP7307137B2 (ja) | 2014-12-26 | 2021-11-11 | GST-π遺伝子を調節するためのRNA干渉剤 |
| JP2023106970A Active JP7655971B2 (ja) | 2014-12-26 | 2023-06-29 | GST-π遺伝子を調節するためのRNA干渉剤 |
| JP2025046972A Pending JP2025102833A (ja) | 2014-12-26 | 2025-03-21 | GST-π遺伝子を調節するためのRNA干渉剤 |
Family Applications Before (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017534294A Active JP6730285B2 (ja) | 2014-12-26 | 2015-12-28 | Rna干渉組成物及び悪性腫瘍のための方法 |
| JP2017534287A Pending JP2018513669A (ja) | 2014-12-26 | 2015-12-28 | Gst−pi遺伝子調節のためのrna剤 |
| JP2017534274A Pending JP2018513104A (ja) | 2014-12-26 | 2015-12-28 | Hsp47及びp21を標的とするrnai分子による悪性腫瘍の治療用組成物及び方法 |
| JP2017534297A Active JP6457645B2 (ja) | 2014-12-26 | 2015-12-28 | GST−π遺伝子を調節するためのRNA干渉剤 |
| JP2017534275A Pending JP2018512373A (ja) | 2014-12-26 | 2015-12-28 | Kras突然変異に関連する悪性腫瘍に対する治療のための方法及び組成物 |
| JP2017534286A Active JP6793649B2 (ja) | 2014-12-26 | 2015-12-28 | P21遺伝子調節のためのrna剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021183788A Active JP7307137B2 (ja) | 2014-12-26 | 2021-11-11 | GST-π遺伝子を調節するためのRNA干渉剤 |
| JP2023106970A Active JP7655971B2 (ja) | 2014-12-26 | 2023-06-29 | GST-π遺伝子を調節するためのRNA干渉剤 |
| JP2025046972A Pending JP2025102833A (ja) | 2014-12-26 | 2025-03-21 | GST-π遺伝子を調節するためのRNA干渉剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (14) | US10264976B2 (OSRAM) |
| EP (9) | EP3236969A4 (OSRAM) |
| JP (10) | JP6730285B2 (OSRAM) |
| KR (4) | KR102527430B1 (OSRAM) |
| CN (7) | CN108064155B (OSRAM) |
| AU (4) | AU2015369596A1 (OSRAM) |
| BR (2) | BR112017013597B1 (OSRAM) |
| CA (4) | CA2972270A1 (OSRAM) |
| RU (4) | RU2756253C2 (OSRAM) |
| WO (7) | WO2016106405A1 (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10792299B2 (en) | 2014-12-26 | 2020-10-06 | Nitto Denko Corporation | Methods and compositions for treating malignant tumors associated with kras mutation |
| US20180002702A1 (en) * | 2014-12-26 | 2018-01-04 | Nitto Denko Corporation | Methods and compositions for treating malignant tumors associated with kras mutation |
| US11045488B2 (en) | 2014-12-26 | 2021-06-29 | Nitto Denko Corporation | RNA interference agents for GST-π gene modulation |
| US10264976B2 (en) * | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
| PT3236974T (pt) * | 2014-12-26 | 2020-06-01 | Nitto Denko Corp | Agentes de interferência de rna para modulação génica de gst-pi |
| CA2990668C (en) | 2015-06-24 | 2024-07-02 | Nitto Denko Corporation | IONIZABLE COMPOUNDS AND RELATED COMPOSITIONS AND USES |
| BR112018008344A2 (pt) | 2015-12-13 | 2018-10-30 | Nitto Denko Corp | molécula de ácido nucleico, composição farmacêutica, vetor ou célula, método para prevenir, tratar ou melhorar uma doença, e, uso de uma composição |
| KR102584661B1 (ko) | 2016-05-10 | 2023-10-04 | 고쿠리츠 다이가쿠호우징 도쿄이카시카다이가쿠 | 염증 촉진 인자 발현 억제제, 그 유효 성분의 스크리닝 방법, 그 방법에 유용한 발현 카세트, 진단약 및 진단 방법 |
| JP2019508379A (ja) * | 2017-02-16 | 2019-03-28 | 日東電工株式会社 | 悪性腫瘍に対する治療方法及び治療用組成物 |
| WO2019090359A1 (en) | 2017-11-06 | 2019-05-09 | Nitto Denko Corporation | Fusogenic compounds for delivery of biologically active molecules |
| KR102715821B1 (ko) * | 2017-11-09 | 2024-10-10 | 고쿠리츠 다이가쿠호우징 도쿄이카시카다이가쿠 | 암 촉진 인자 발현 억제제, 그 유효 성분의 스크리닝 방법, 그 방법에 유용한 발현 카세트, 진단약, 및 진단 방법 |
| CN109777798A (zh) * | 2017-11-13 | 2019-05-21 | 深圳华大生命科学研究院 | 一种基于CRISPR技术治疗KRAS突变恶性肿瘤的sgRNA及其应用 |
| JP6952594B2 (ja) * | 2017-12-15 | 2021-10-20 | 洋司郎 新津 | 細胞増殖抑制剤及びそれを含むがんの治療若しくは予防用医薬組成物 |
| CN108486011B (zh) * | 2018-03-27 | 2020-05-05 | 山东大学 | 一种三联苯化合物、制备方法及其应用 |
| JP7432929B2 (ja) * | 2018-05-31 | 2024-02-19 | コリア ユニバーシティ リサーチ アンド ビジネス ファウンデーション | マイクロrnaの非正規標的を抑制するrna干渉誘導核酸およびその用途 |
| WO2020009189A1 (ja) * | 2018-07-05 | 2020-01-09 | 洋司郎 新津 | Braf阻害剤によるがん細胞の逆説的増殖を抑制する薬剤 |
| CN112739381A (zh) * | 2018-08-22 | 2021-04-30 | 日东电工株式会社 | 使用了hsp47的抑制物质的癌转移抑制 |
| CN112739382A (zh) * | 2018-08-22 | 2021-04-30 | 日东电工株式会社 | 使用了hsp47的抑制物质的化疗剂敏感性的增强 |
| PT3880212T (pt) * | 2018-11-16 | 2024-02-08 | Nitto Denko Corp | Formulação e métodos de administração de rna de interferência para tumores malignos |
| EP3906930A4 (en) * | 2018-12-05 | 2022-08-24 | Nitto Denko Corporation | RNAI MOLECULE FOR TREATMENT OF CANCER |
| EP3909588A4 (en) | 2019-01-10 | 2023-01-04 | Osaka University | IMMUNO-STIMULATING COMPOSITION |
| JPWO2020196736A1 (OSRAM) * | 2019-03-28 | 2020-10-01 | ||
| JP2019116507A (ja) * | 2019-04-25 | 2019-07-18 | 有限会社オービット | Hsp47の発現促進剤、脱毛抑制方法、Hsp47の発現促進剤の製造方法及び飲食物の製造方法 |
| EP3965781A2 (en) * | 2019-07-02 | 2022-03-16 | Argonaute Rna Limited | Apolipoprotein b antagonist |
| EP4005602A4 (en) * | 2019-07-30 | 2024-06-12 | Shionogi & Co., Ltd | NUCLEIC ACID AGENT TARGETED AGAINST MURF1 |
| US20230061751A1 (en) * | 2020-01-17 | 2023-03-02 | University Of Massachusetts | Universal dynamic pharmacokinetic-modifying anchors |
| CN112280800B (zh) * | 2020-10-19 | 2022-06-07 | 上海市东方医院(同济大学附属东方医院) | 一种构建体及其在制备动物衰老细胞示踪和衰老细胞清除药物中的应用 |
| AU2021411103B2 (en) * | 2020-12-28 | 2025-04-24 | 1E Therapeutics, Ltd. | P21 mrna target areas for silencing |
| AU2021416356A1 (en) | 2020-12-28 | 2023-08-10 | 1E Therapeutics, Ltd. | P21 mrna targeting dnazymes |
| KR102732909B1 (ko) * | 2021-12-29 | 2024-11-20 | 의료법인 명지의료재단 | K-ras 특이적 활성화 T 세포를 포함하는 폐 유두상 선암종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법 |
| KR102732910B1 (ko) * | 2021-12-29 | 2024-11-20 | 의료법인 명지의료재단 | K-ras 특이적 활성화 T 세포를 포함하는 대장암의 예방 및 치료용 약제학적 조성물 및 이의 제조방법 |
| KR102732911B1 (ko) * | 2021-12-29 | 2024-11-20 | 의료법인 명지의료재단 | K-ras 특이적 활성화 T 세포를 포함하는 유방암의 예방 및 치료용 약제학적 조성물 및 이의 제조방법 |
| KR102732912B1 (ko) * | 2021-12-29 | 2024-11-20 | 의료법인 명지의료재단 | K-ras 특이적 활성화 T 세포를 포함하는 폐 선암종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법 |
| KR102732913B1 (ko) * | 2021-12-29 | 2024-11-20 | 의료법인 명지의료재단 | K-ras 특이적 활성화 T 세포를 포함하는 흑색종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법 |
| JPWO2023210713A1 (OSRAM) * | 2022-04-27 | 2023-11-02 | ||
| WO2025072649A1 (en) * | 2023-09-28 | 2025-04-03 | Nitto Denko Corporation | Combination therapy |
Family Cites Families (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR970005898B1 (ko) | 1987-09-21 | 1997-04-21 | 젠- 프로우브 인코퍼레이티드 | 뉴클레오티드 프로브에 대한 비-뉴클레오티드 연결시약 |
| US5204241A (en) | 1990-10-22 | 1993-04-20 | Oxi-Gene Inc. | Glutathione-S-transferase mu as a measure of drug resistance |
| US5786336A (en) | 1991-04-29 | 1998-07-28 | Terrapin Technologies, Inc. | Target-selective protocols based on mimics |
| US5658780A (en) | 1992-12-07 | 1997-08-19 | Ribozyme Pharmaceuticals, Inc. | Rel a targeted ribozymes |
| ATE227342T1 (de) | 1993-09-02 | 2002-11-15 | Ribozyme Pharm Inc | Enzymatische nukleiksaüre die nicht-nukleotide enthaltet |
| CA2174339A1 (en) | 1993-10-27 | 1995-05-04 | Lech W. Dudycz | 2'-amido and 2'-peptido modified oligonucleotides |
| DE69633722T2 (de) | 1995-06-07 | 2005-11-03 | TELIK, INC., Palo Alto | Stoffwechseleffekt von bestimmten glutation analogen |
| US5968737A (en) | 1996-11-12 | 1999-10-19 | The University Of Mississippi | Method of identifying inhibitors of glutathione S-transferase (GST) gene expression |
| JPH10330249A (ja) * | 1997-05-30 | 1998-12-15 | Kureha Chem Ind Co Ltd | レチノール化合物含有hsp47合成抑制剤 |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| CA2328731A1 (en) | 1998-04-16 | 1999-10-28 | Atsushi Imaizumi | Glutathione derivatives and dosage forms thereof |
| GB9827152D0 (en) | 1998-07-03 | 1999-02-03 | Devgen Nv | Characterisation of gene function using double stranded rna inhibition |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| JP2003516124A (ja) | 1999-10-15 | 2003-05-13 | ユニバーシティー オブ マサチューセッツ | 標的とした遺伝的干渉の手段としてのrna干渉経路遺伝子 |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| WO2005019453A2 (en) | 2001-05-18 | 2005-03-03 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA) |
| US20070083945A1 (en) | 2000-03-10 | 2007-04-12 | Byrum Joseph R | Nucleic acid molecules and other molecules associated with plants |
| WO2001088191A1 (en) * | 2000-03-29 | 2001-11-22 | The United States Of America As Represented By The Department Of Veterans Affairs | A novel specific inhibitor of the cyclin kinase inhibitor p21?waf1/cip1¿ |
| WO2002010449A2 (en) | 2000-07-28 | 2002-02-07 | Compugen Inc. | Oligonucleotide library for detecting rna transcripts and splice variants that populate a transcriptome |
| US20040259247A1 (en) | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US20030099974A1 (en) | 2001-07-18 | 2003-05-29 | Millennium Pharmaceuticals, Inc. | Novel genes, compositions, kits and methods for identification, assessment, prevention, and therapy of breast cancer |
| US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| US20040029275A1 (en) * | 2002-08-10 | 2004-02-12 | David Brown | Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs |
| DK2284266T3 (da) * | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
| WO2004055165A2 (en) | 2002-12-13 | 2004-07-01 | St. Jude Children's Research Hospital | Glutathione-s-transferase test for susceptibility to parkinson's |
| WO2004094636A1 (en) | 2003-04-24 | 2004-11-04 | Galapagos Genomics N.V. | Effective sirna knock-down constructs |
| US20050142596A1 (en) | 2003-11-14 | 2005-06-30 | Krolewski Andrzej S. | Methods of diagnosing renal and cardiovascular disease |
| JP5243789B2 (ja) | 2004-03-15 | 2013-07-24 | シティ・オブ・ホープ | 二本鎖rnaによる遺伝子発現の特異的阻害のための方法及び組成物 |
| CA2566519C (en) * | 2004-05-14 | 2020-04-21 | Rosetta Genomics Ltd. | Micrornas and uses thereof |
| MX2007002294A (es) | 2004-08-26 | 2007-10-19 | Engeneic Molecular Delivery Pty Ltd | Suministro de acidos nucleicos funcionales a celulas mamiferas via minicelulas intactas, derivadas bacterialmente. |
| US9393315B2 (en) * | 2011-06-08 | 2016-07-19 | Nitto Denko Corporation | Compounds for targeting drug delivery and enhancing siRNA activity |
| SI2727583T1 (sl) | 2004-12-22 | 2022-01-31 | Nitto Denko Corporation | Nosilec učinkovine in komplet nosilca učinkovine za zaviranje fibroze |
| JP2008536874A (ja) | 2005-04-15 | 2008-09-11 | ボード オブ リージェンツ ザ ユニバーシティー オブ テキサス システム | 中性脂質組成物によるsiRNAの送達 |
| WO2007072220A2 (en) * | 2005-09-12 | 2007-06-28 | Aurelium Biopharma Inc. | Focused microarray and methods of diagnosing cancer |
| ES2324128A1 (es) * | 2005-09-29 | 2009-07-30 | Proyecto De Biomedicina Cima, S.L. | Metodo para el diagnostico de carcinoma hepatocelular mediante el empleo de marcadores moleculares. |
| EP1954820A1 (en) | 2005-10-25 | 2008-08-13 | Het Nederlands Kanker Instituut | Prediction of local recurrence of breast cancer |
| RU2448974C2 (ru) * | 2005-11-01 | 2012-04-27 | Элнилэм Фармасьютикалз, Инк. | РНКи-ИНГИБИРОВАНИЕ РЕПЛИКАЦИИ ВИРУСА ГРИППА |
| US20070197460A1 (en) | 2005-11-01 | 2007-08-23 | Alnylam Pharmaceuticals, Inc. | Rnai inhibition of influenza virus replication |
| CN101346393B (zh) * | 2005-11-02 | 2015-07-22 | 普洛体维生物治疗公司 | 修饰的siRNA分子及其应用 |
| EP1948213B1 (en) | 2005-11-17 | 2009-02-04 | The Children's Medical Center Corporation | Methods to predict and prevent resistance to taxoid compounds |
| US7729737B2 (en) | 2005-11-22 | 2010-06-01 | Isense Corporation | Method and apparatus for background current arrangements for a biosensor |
| EP1957044B1 (en) | 2005-12-01 | 2013-03-13 | Pronai Therapeutics, Inc. | Amphoteric liposome formulation |
| US9572886B2 (en) * | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
| JP5342834B2 (ja) * | 2008-09-05 | 2013-11-13 | 日東電工株式会社 | 骨髄線維症処置剤 |
| WO2007130604A2 (en) * | 2006-05-04 | 2007-11-15 | Baylor Research Institute | Anti-tumor activity of an oncolytic adenovirus-delivered oncogene sirna |
| KR101320916B1 (ko) * | 2006-05-11 | 2013-10-23 | 알닐람 파마슈티칼스 인코포레이티드 | Pcsk9 유전자의 발현을 억제하기 위한 조성물 및 방법 |
| US8067390B2 (en) | 2007-03-02 | 2011-11-29 | The Board Of Regents Of The University Of Texas System | Therapeutic targeting of interleukins using siRNA in neutral liposomes |
| TWI407971B (zh) * | 2007-03-30 | 2013-09-11 | Nitto Denko Corp | Cancer cells and tumor-related fibroblasts |
| WO2008124634A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Polymer-encapsulated reverse micelles |
| AU2008270209B2 (en) | 2007-07-05 | 2012-05-17 | Arrowhead Pharmaceuticals, Inc. | dsRNA for treating viral infection |
| WO2009029688A2 (en) * | 2007-08-27 | 2009-03-05 | Boston Biomedical, Inc. | Compositions of asymmetric interfering rna and uses thereof |
| WO2009033284A1 (en) * | 2007-09-14 | 2009-03-19 | Mcmaster University | Inhibitors of collagen biosynthesis as anti-tumor agents |
| CA2715796C (en) * | 2008-03-06 | 2015-04-28 | Rottapharm S.P.A. | 2-aryl and 2 -heteroaryl 4h-1-benzopyran-4-one-6-amidino derivatives for the treatment of arthritis, cancer and related pain |
| EP2321414B1 (en) | 2008-07-25 | 2018-01-10 | Alnylam Pharmaceuticals, Inc. | Enhancement of sirna silencing activity using universal bases or mismatches in the sense strand |
| KR20110051214A (ko) * | 2008-07-30 | 2011-05-17 | 닛토덴코 가부시키가이샤 | 약물 담체 |
| EP2496700B1 (en) * | 2009-11-04 | 2017-03-01 | The University Of British Columbia | Nucleic acid-containing lipid particles and related methods |
| DK2509991T3 (en) | 2009-12-09 | 2015-12-21 | Nitto Denko Corp | MODULATION OF HSP47 EXPRESSION |
| CN102859004A (zh) | 2010-02-24 | 2013-01-02 | 波蒂塞克股份有限公司 | 确定基因-营养物的相互作用的方法 |
| US20130004494A1 (en) * | 2010-03-12 | 2013-01-03 | Ellen Heber-Katz | Inhibition of P21 and Use Thereof for Inducing Tissue Regeneration |
| US8372819B2 (en) | 2010-04-11 | 2013-02-12 | Salk Institute For Biological Studies | Methods and compositions for targeting skip |
| WO2011131472A1 (en) | 2010-04-22 | 2011-10-27 | Institut Gustave Roussy | Compounds and uses thereof to induce an immunogenic cancer cell death in a subject |
| AU2011249406B2 (en) | 2010-05-06 | 2015-05-14 | Stem Cell Medicine Ltd. | Stem cell bank for personalized medicine |
| JP5950428B2 (ja) * | 2010-08-05 | 2016-07-13 | 日東電工株式会社 | 線維化組織から正常組織を再生するための組成物 |
| AU2011307259A1 (en) | 2010-09-30 | 2013-05-02 | Nitto Denko Corporation | Modulation of TIMP1 and TIMP2 expression |
| CN110123830A (zh) | 2010-11-09 | 2019-08-16 | 阿尔尼拉姆医药品有限公司 | 用于抑制Eg5和VEGF基因的表达的脂质配制的组合物和方法 |
| US9011903B2 (en) * | 2011-06-08 | 2015-04-21 | Nitto Denko Corporation | Cationic lipids for therapeutic agent delivery formulations |
| CN107082747B (zh) * | 2011-06-08 | 2020-11-20 | 日东电工株式会社 | 用于定向药物输送和增强siRNA活性的化合物 |
| TWI658830B (zh) | 2011-06-08 | 2019-05-11 | 日東電工股份有限公司 | Hsp47表現調控強化用類視色素脂質體 |
| ES2708932T3 (es) * | 2011-06-21 | 2019-04-12 | Nitto Denko Corp | Agente inductor de apoptosis |
| CN102896619B (zh) * | 2011-07-26 | 2015-04-22 | 苏州宝时得电动工具有限公司 | 动力工具及其操作方法 |
| WO2013066485A2 (en) * | 2011-08-31 | 2013-05-10 | Asea Alexzander A | Compositions and methods for treatment of metastatic cancer |
| US9579338B2 (en) | 2011-11-04 | 2017-02-28 | Nitto Denko Corporation | Method of producing lipid nanoparticles for drug delivery |
| US9631192B2 (en) * | 2011-11-17 | 2017-04-25 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Auto-recognizing therapeutic RNA/DNA chimeric nanoparticles (NP) |
| AU2013262972A1 (en) * | 2012-05-16 | 2014-12-11 | Aadigen, Llc | Multi-target modulation for treating fibrosis and inflammatory conditions |
| US20140134158A1 (en) * | 2012-05-22 | 2014-05-15 | Alberto Bardelli | Kras mutations and resistance to anti-egfr treatment |
| TR201816986T4 (tr) | 2012-06-08 | 2019-01-21 | Nitto Denko Corp | Terapötik ajan iletim formülasyonlarına yönelik lipitler. |
| WO2013192364A1 (en) | 2012-06-22 | 2013-12-27 | The University Of Vermont And State Agricultural College | Treatments of oxidative stress conditions |
| HK1209639A1 (en) * | 2012-07-02 | 2016-04-08 | Fibrostatin, S.L. | Gpbp-1 inhibition and its therapeutic use |
| US9708607B2 (en) * | 2012-08-03 | 2017-07-18 | Alnylam Pharmaceuticals, Inc. | Modified RNAi agents |
| JP6340162B2 (ja) * | 2012-12-20 | 2018-06-06 | 日東電工株式会社 | アポトーシス誘導剤 |
| EA201891018A1 (ru) | 2013-03-08 | 2018-09-28 | Новартис Аг | Липиды и липидные композиции для доставки активных агентов |
| CN103695421B (zh) | 2013-12-09 | 2016-06-15 | 浙江大学 | 一种特异抑制p21基因表达的siRNA及其应用 |
| WO2016104588A1 (ja) * | 2014-12-26 | 2016-06-30 | 日東電工株式会社 | 細胞死誘導剤、細胞増殖抑制剤及び細胞の増殖異常に起因する疾患の治療用医薬組成物 |
| US20160187319A1 (en) * | 2014-12-26 | 2016-06-30 | Nitto Denko Corporation | Cell death-inducing agent, cell growth-inhibiting agent, and pharmaceutical composition for treatment of disease caused by abnormal cell growth |
| US10264976B2 (en) * | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
| US10792299B2 (en) * | 2014-12-26 | 2020-10-06 | Nitto Denko Corporation | Methods and compositions for treating malignant tumors associated with kras mutation |
| US20180002702A1 (en) | 2014-12-26 | 2018-01-04 | Nitto Denko Corporation | Methods and compositions for treating malignant tumors associated with kras mutation |
| BR112018008344A2 (pt) * | 2015-12-13 | 2018-10-30 | Nitto Denko Corp | molécula de ácido nucleico, composição farmacêutica, vetor ou célula, método para prevenir, tratar ou melhorar uma doença, e, uso de uma composição |
| JP6899201B2 (ja) | 2016-06-23 | 2021-07-07 | 日東電工株式会社 | 細胞死誘導剤、細胞増殖抑制剤及び細胞の増殖異常に起因する疾患の治療用医薬組成物 |
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