JP2014527401A5 - - Google Patents
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- JP2014527401A5 JP2014527401A5 JP2014518986A JP2014518986A JP2014527401A5 JP 2014527401 A5 JP2014527401 A5 JP 2014527401A5 JP 2014518986 A JP2014518986 A JP 2014518986A JP 2014518986 A JP2014518986 A JP 2014518986A JP 2014527401 A5 JP2014527401 A5 JP 2014527401A5
- Authority
- JP
- Japan
- Prior art keywords
- double
- acid molecule
- ribonucleic acid
- stranded ribonucleic
- nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920002477 rna polymer Polymers 0.000 claims 37
- 125000003729 nucleotide group Chemical group 0.000 claims 22
- 239000002773 nucleotide Substances 0.000 claims 20
- 108091081021 Sense strand Proteins 0.000 claims 14
- 230000000692 anti-sense effect Effects 0.000 claims 10
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 8
- 150000007523 nucleic acids Chemical group 0.000 claims 8
- 241000700721 Hepatitis B virus Species 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 230000007918 pathogenicity Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 229940035893 uracil Drugs 0.000 claims 2
- 230000029812 viral genome replication Effects 0.000 claims 2
- 208000035657 Abasia Diseases 0.000 claims 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 125000001921 locked nucleotide group Chemical group 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- ONKSSDKXDIVIHK-UHFFFAOYSA-N n,n-didecyldodecanamide Chemical group CCCCCCCCCCCC(=O)N(CCCCCCCCCC)CCCCCCCCCC ONKSSDKXDIVIHK-UHFFFAOYSA-N 0.000 claims 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11172235 | 2011-06-30 | ||
| EP11172235.1 | 2011-06-30 | ||
| PCT/US2012/044505 WO2013003520A1 (en) | 2011-06-30 | 2012-06-28 | Compositions and methods for inhibiting gene expression of hepatitis b virus |
| US13/535,454 US8809293B2 (en) | 2011-06-30 | 2012-06-28 | Compositions and methods for inhibiting gene expression of hepatitis B virus |
| US13/535,454 | 2012-06-28 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017073870A Division JP2017169568A (ja) | 2011-06-30 | 2017-04-03 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527401A JP2014527401A (ja) | 2014-10-16 |
| JP2014527401A5 true JP2014527401A5 (OSRAM) | 2015-08-06 |
| JP6165723B2 JP6165723B2 (ja) | 2017-07-19 |
Family
ID=47391267
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014518986A Active JP6165723B2 (ja) | 2011-06-30 | 2012-06-28 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
| JP2017073870A Withdrawn JP2017169568A (ja) | 2011-06-30 | 2017-04-03 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
| JP2019078663A Active JP6959293B2 (ja) | 2011-06-30 | 2019-04-17 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
| JP2021130741A Pending JP2021191274A (ja) | 2011-06-30 | 2021-08-10 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
| JP2023150873A Pending JP2023179497A (ja) | 2011-06-30 | 2023-09-19 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017073870A Withdrawn JP2017169568A (ja) | 2011-06-30 | 2017-04-03 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
| JP2019078663A Active JP6959293B2 (ja) | 2011-06-30 | 2019-04-17 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
| JP2021130741A Pending JP2021191274A (ja) | 2011-06-30 | 2021-08-10 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
| JP2023150873A Pending JP2023179497A (ja) | 2011-06-30 | 2023-09-19 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8809293B2 (OSRAM) |
| EP (3) | EP3901263A1 (OSRAM) |
| JP (5) | JP6165723B2 (OSRAM) |
| KR (5) | KR102025295B1 (OSRAM) |
| CN (3) | CN106434665B (OSRAM) |
| AU (5) | AU2012275355B2 (OSRAM) |
| BR (1) | BR112013031021A2 (OSRAM) |
| CA (2) | CA2833778C (OSRAM) |
| DK (1) | DK2726613T3 (OSRAM) |
| EA (4) | EA202090994A1 (OSRAM) |
| ES (1) | ES2690538T3 (OSRAM) |
| HR (1) | HRP20181564T1 (OSRAM) |
| IL (3) | IL230226B (OSRAM) |
| MX (2) | MX342731B (OSRAM) |
| PL (1) | PL2726613T3 (OSRAM) |
| PT (1) | PT2726613T (OSRAM) |
| SG (1) | SG194751A1 (OSRAM) |
| SI (1) | SI2726613T1 (OSRAM) |
| TW (5) | TWI786401B (OSRAM) |
| WO (1) | WO2013003520A1 (OSRAM) |
| ZA (1) | ZA201307914B (OSRAM) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3587574B1 (en) | 2010-08-17 | 2022-03-16 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina) |
| JP6042871B2 (ja) | 2011-04-21 | 2016-12-14 | アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | Ｂ型肝炎ウイルス（ｈｂｖ）発現の調節 |
| CN106434665B (zh) | 2011-06-30 | 2021-06-08 | 箭头药业股份有限公司 | 用于抑制乙型肝炎病毒的基因表达的组合物和方法 |
| JP6270846B2 (ja) | 2012-08-30 | 2018-01-31 | レプリコール インコーポレーティッド | Ｂ型肝炎感染及びｄ型肝炎感染の治療方法 |
| SG11201503821YA (en) | 2012-11-15 | 2015-06-29 | Roche Innovation Ct Copenhagen As | Oligonucleotide conjugates |
| RU2649367C2 (ru) | 2013-01-30 | 2018-04-02 | Ф. Хоффманн-Ля Рош Аг | Конъюгаты углевода и lna-олигонуклеотида |
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| WO2015051366A2 (en) | 2013-10-04 | 2015-04-09 | Novartis Ag | Novel formats for organic compounds for use in rna interference |
| EP3052107B1 (en) * | 2013-10-04 | 2018-05-02 | Novartis AG | Organic compounds to treat hepatitis b virus |
| GB201408623D0 (en) * | 2014-05-15 | 2014-07-02 | Santaris Pharma As | Oligomers and oligomer conjugates |
| WO2016011123A1 (en) * | 2014-07-16 | 2016-01-21 | Arrowhead Research Corporation | Organic compositions to treat apoc3-related diseases |
| KR20170075742A (ko) * | 2014-10-02 | 2017-07-03 | 프로티바 바이오쎄라퓨틱스, 인코포레이티드 | B형 간염 바이러스 유전자 발현을 제거하는 조성물 및 방법 |
| JOP20200092A1 (ar) * | 2014-11-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها |
| JP2018500932A (ja) * | 2014-12-22 | 2018-01-18 | アナーパ バイオテック エー／エス | 標的核酸のマルチプレックス検出のためのデュアルクエンチングアッセイ |
| KR20170141257A (ko) | 2015-05-06 | 2017-12-22 | 베니텍 바이오파마 리미티드 | B형 간염 바이러스 (hbv) 감염의 치료를 위한 시약 및 이의 용도 |
| US20170137821A1 (en) | 2015-07-17 | 2017-05-18 | Arcturus Therapeutics, Inc. | Molecules and agents for treating hepatitis b virus |
| AU2016296592B2 (en) * | 2015-07-17 | 2021-08-19 | Arcturus Therapeutics, Inc. | Compositions and agents against Hepatitis B virus and uses thereof |
| WO2017019891A2 (en) * | 2015-07-29 | 2017-02-02 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing hepatitis b virus gene expression |
| JO3769B1 (ar) * | 2015-08-07 | 2021-01-31 | Arrowhead Pharmaceuticals Inc | علاج RNAi لعدوى فيروس التهاب الكبد B |
| KR20180038465A (ko) | 2015-08-07 | 2018-04-16 | 애로우헤드 파마슈티컬스 인코포레이티드 | Ｂ형 간염 바이러스 감염에 대한 ｒｎａｉ 치료법 |
| CN109069529B (zh) * | 2016-03-07 | 2021-08-20 | 箭头药业股份有限公司 | 用于治疗性化合物的靶向配体 |
| CN108713061B (zh) * | 2016-03-09 | 2022-04-05 | 学校法人东京理科大学 | Rna杂交形成用核酸低聚物 |
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| US11535851B2 (en) * | 2016-05-05 | 2022-12-27 | Benitec IP Holdings Inc. | Reagents for treatment of hepatitis B virus (HBV) infection and use thereof |
| MA45496A (fr) | 2016-06-17 | 2019-04-24 | Hoffmann La Roche | Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b |
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| WO2018053185A1 (en) * | 2016-09-14 | 2018-03-22 | Alios Biopharma, Inc. | Modified oligonucleotides and methods of use |
| KR20230010826A (ko) * | 2016-10-14 | 2023-01-19 | 프리시젼 바이오사이언시스 인코포레이티드 | B형 간염 바이러스 게놈 내의 인식 서열에 대해 특이적인 조작된 메가뉴클레아제 |
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