JP2018509935A5 - - Google Patents
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- JP2018509935A5 JP2018509935A5 JP2017567526A JP2017567526A JP2018509935A5 JP 2018509935 A5 JP2018509935 A5 JP 2018509935A5 JP 2017567526 A JP2017567526 A JP 2017567526A JP 2017567526 A JP2017567526 A JP 2017567526A JP 2018509935 A5 JP2018509935 A5 JP 2018509935A5
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- Prior art keywords
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- 210000004027 cell Anatomy 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 7
- 230000000890 antigenic effect Effects 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 229940122985 Peptide agonist Drugs 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 claims 4
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 claims 4
- 102000002689 Toll-like receptor Human genes 0.000 claims 4
- 108020000411 Toll-like receptor Proteins 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 241000283070 Equus zebra Species 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 claims 2
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 2
- 102100024333 Toll-like receptor 2 Human genes 0.000 claims 2
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 101000669460 Homo sapiens Toll-like receptor 5 Proteins 0.000 claims 1
- 102100039357 Toll-like receptor 5 Human genes 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000009813 cataract 31 multiple types Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 208000014951 hematologic disease Diseases 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021059082A JP7179896B2 (ja) | 2015-03-16 | 2021-03-31 | 細胞透過性ペプチド、カーゴ、及びｔｌｒペプチドアゴニストを含む新規複合体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2015/000580 | 2015-03-16 | ||
| EP2015000580 | 2015-03-16 | ||
| EP2015002244 | 2015-11-09 | ||
| EPPCT/EP2015/002244 | 2015-11-09 | ||
| PCT/EP2016/000471 WO2016146260A1 (en) | 2015-03-16 | 2016-03-16 | A novel complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021059082A Division JP7179896B2 (ja) | 2015-03-16 | 2021-03-31 | 細胞透過性ペプチド、カーゴ、及びｔｌｒペプチドアゴニストを含む新規複合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018509935A JP2018509935A (ja) | 2018-04-12 |
| JP2018509935A5 true JP2018509935A5 (OSRAM) | 2019-03-22 |
| JP6862369B2 JP6862369B2 (ja) | 2021-04-21 |
Family
ID=55066559
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017567525A Active JP6882207B2 (ja) | 2015-03-16 | 2016-03-16 | 神経膠芽腫を治療するための細胞透過性ペプチド、カーゴ、及びｔｌｒペプチドアゴニストを含む新規複合体 |
| JP2017567527A Active JP6993240B2 (ja) | 2015-03-16 | 2016-03-16 | 結腸直腸癌を治療するための細胞透過性ペプチド、カーゴ、及びｔｌｒペプチドアゴニストを含む新規複合体 |
| JP2017567526A Active JP6862369B2 (ja) | 2015-03-16 | 2016-03-16 | 細胞透過性ペプチド、カーゴ、及びｔｌｒペプチドアゴニストを含む新規複合体 |
| JP2021059082A Active JP7179896B2 (ja) | 2015-03-16 | 2021-03-31 | 細胞透過性ペプチド、カーゴ、及びｔｌｒペプチドアゴニストを含む新規複合体 |
| JP2021078278A Active JP7190528B2 (ja) | 2015-03-16 | 2021-05-06 | 神経膠芽腫を治療するための細胞透過性ペプチド、カーゴ、及びｔｌｒペプチドアゴニストを含む新規複合体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017567525A Active JP6882207B2 (ja) | 2015-03-16 | 2016-03-16 | 神経膠芽腫を治療するための細胞透過性ペプチド、カーゴ、及びｔｌｒペプチドアゴニストを含む新規複合体 |
| JP2017567527A Active JP6993240B2 (ja) | 2015-03-16 | 2016-03-16 | 結腸直腸癌を治療するための細胞透過性ペプチド、カーゴ、及びｔｌｒペプチドアゴニストを含む新規複合体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021059082A Active JP7179896B2 (ja) | 2015-03-16 | 2021-03-31 | 細胞透過性ペプチド、カーゴ、及びｔｌｒペプチドアゴニストを含む新規複合体 |
| JP2021078278A Active JP7190528B2 (ja) | 2015-03-16 | 2021-05-06 | 神経膠芽腫を治療するための細胞透過性ペプチド、カーゴ、及びｔｌｒペプチドアゴニストを含む新規複合体 |
Country Status (24)
| Country | Link |
|---|---|
| US (7) | US20180133327A1 (OSRAM) |
| EP (4) | EP3270955B1 (OSRAM) |
| JP (5) | JP6882207B2 (OSRAM) |
| KR (2) | KR102212451B1 (OSRAM) |
| CN (1) | CN107428845A (OSRAM) |
| AU (5) | AU2016232657B9 (OSRAM) |
| CA (3) | CA2973747A1 (OSRAM) |
| CL (1) | CL2017002345A1 (OSRAM) |
| CY (1) | CY1122953T1 (OSRAM) |
| DK (3) | DK3270955T3 (OSRAM) |
| EA (1) | EA038049B1 (OSRAM) |
| ES (3) | ES2781454T3 (OSRAM) |
| HR (1) | HRP20200491T1 (OSRAM) |
| HU (3) | HUE066851T2 (OSRAM) |
| IL (2) | IL253416B (OSRAM) |
| LT (1) | LT3270955T (OSRAM) |
| MX (1) | MX2017011796A (OSRAM) |
| NZ (1) | NZ733762A (OSRAM) |
| PH (1) | PH12017501287A1 (OSRAM) |
| PL (3) | PL3693009T3 (OSRAM) |
| PT (2) | PT3270955T (OSRAM) |
| RS (1) | RS60089B1 (OSRAM) |
| SI (1) | SI3270955T1 (OSRAM) |
| WO (5) | WO2016146143A1 (OSRAM) |
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| WO2016146143A1 (en) | 2015-03-16 | 2016-09-22 | Amal Therapeutics Sa | Cell penetrating peptides and complexes comprising the same |
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| JP6864296B2 (ja) | 2015-12-14 | 2021-04-28 | エックス４ ファーマシューティカルズ， インコーポレイテッド | がんを処置する方法 |
| PL3393468T3 (pl) | 2015-12-22 | 2023-01-23 | X4 Pharmaceuticals, Inc. | Metody leczenia niedoboru odporności |
| LT3429618T (lt) | 2016-03-16 | 2024-05-10 | Amal Therapeutics Sa | Imuninės sistemos patikros taško moduliatoriaus ir komplekso, apimančio į ląsteles prasiskverbiantį peptidą, krovinį ir tlr peptido agonistą, derinys, skirtas naudoti medicinoje |
| CA3019394A1 (en) | 2016-04-08 | 2017-10-12 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| JP7084624B2 (ja) | 2016-06-21 | 2022-06-15 | エックス４ ファーマシューティカルズ， インコーポレイテッド | Ｃｘｃｒ４阻害剤およびその使用 |
| ES2870920T3 (es) | 2016-06-21 | 2021-10-28 | X4 Pharmaceuticals Inc | Inhibidores de CXCR4 y usos de los mismos |
| JP6994767B2 (ja) | 2016-06-21 | 2022-01-14 | エックス４ ファーマシューティカルズ， インコーポレイテッド | Ｃｘｃｒ４阻害剤およびその使用 |
| CN109963585B (zh) * | 2016-09-21 | 2024-10-15 | 阿尔勒治疗公司 | 包括细胞穿透肽、多表位和tlr肽激动剂的用于治疗癌症的融合物 |
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| EP3522916A2 (en) | 2016-10-07 | 2019-08-14 | Enterome S.A. | Immunogenic compounds for cancer therapy |
| EP3526259A4 (en) * | 2016-10-13 | 2020-06-17 | Dana-Farber Cancer Institute, Inc. | COMPOSITIONS AND METHODS FOR PREDICTING RESPONSE AND RESISTANCE TO CTLA4 BLOCKAGE IN MELANOMA USING GENE EXPRESSION SIGNATURE |
| KR101875055B1 (ko) * | 2016-10-19 | 2018-07-06 | 연세대학교 원주산학협력단 | 융합 단백질 및 그의 용도 |
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