JP2015529677A5 - - Google Patents
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- Publication number
- JP2015529677A5 JP2015529677A5 JP2015531683A JP2015531683A JP2015529677A5 JP 2015529677 A5 JP2015529677 A5 JP 2015529677A5 JP 2015531683 A JP2015531683 A JP 2015531683A JP 2015531683 A JP2015531683 A JP 2015531683A JP 2015529677 A5 JP2015529677 A5 JP 2015529677A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antigen
- toxa
- polypeptide
- immunogenic composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims description 64
- 102000036639 antigens Human genes 0.000 claims description 64
- 108091007433 antigens Proteins 0.000 claims description 64
- 239000000203 mixture Substances 0.000 claims description 52
- 230000002163 immunogen Effects 0.000 claims description 35
- 229920001184 polypeptide Polymers 0.000 claims description 31
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 31
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 31
- 229960005486 vaccine Drugs 0.000 claims description 20
- 241000124008 Mammalia Species 0.000 claims description 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 11
- 150000001413 amino acids Chemical class 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 8
- 230000002265 prevention Effects 0.000 claims description 6
- 230000028993 immune response Effects 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 241000193163 Clostridioides difficile Species 0.000 claims description 2
- 206010061819 Disease recurrence Diseases 0.000 claims description 2
- 101710084578 Short neurotoxin 1 Proteins 0.000 claims description 2
- 101710182223 Toxin B Proteins 0.000 claims description 2
- 101710182532 Toxin a Proteins 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 239000013256 coordination polymer Substances 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 230000000968 intestinal effect Effects 0.000 claims description 2
- 230000003472 neutralizing effect Effects 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201216748A GB201216748D0 (en) | 2012-09-19 | 2012-09-19 | Methods of treatment |
| GB1216749.0 | 2012-09-19 | ||
| GB201216749A GB201216749D0 (en) | 2012-09-19 | 2012-09-19 | Antigen combinations |
| GB1216748.2 | 2012-09-19 | ||
| PCT/IB2013/058673 WO2014045226A1 (en) | 2012-09-19 | 2013-09-19 | Clostridium difficile polypeptides as vaccine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015529677A JP2015529677A (ja) | 2015-10-08 |
| JP2015529677A5 true JP2015529677A5 (OSRAM) | 2016-10-20 |
Family
ID=49725168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531683A Pending JP2015529677A (ja) | 2012-09-19 | 2013-09-19 | ワクチンとしてのＣｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅポリペプチド |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9932374B2 (OSRAM) |
| EP (1) | EP2897637A1 (OSRAM) |
| JP (1) | JP2015529677A (OSRAM) |
| KR (1) | KR20150056540A (OSRAM) |
| CN (1) | CN104582722A (OSRAM) |
| AU (1) | AU2013319821A1 (OSRAM) |
| BR (1) | BR112015004629A2 (OSRAM) |
| CA (1) | CA2882620A1 (OSRAM) |
| IL (1) | IL237172A0 (OSRAM) |
| MX (1) | MX2015002485A (OSRAM) |
| RU (1) | RU2015106916A (OSRAM) |
| SG (1) | SG11201500980WA (OSRAM) |
| WO (1) | WO2014045226A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012245904B2 (en) | 2011-04-22 | 2016-04-21 | Wyeth Llc | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| GB2525177A (en) * | 2014-04-14 | 2015-10-21 | New Royal Holloway & Bedford | Vaccine |
| WO2016131157A1 (en) * | 2015-02-19 | 2016-08-25 | Immune Biosolutions Inc | Clostridium difficile toxins a and/or b antigen and epitope antibody, and pharmaceutical uses thereof |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| CN112703006A (zh) | 2018-06-19 | 2021-04-23 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性组合物 |
| GB202205833D0 (en) | 2022-04-21 | 2022-06-08 | Glaxosmithkline Biologicals Sa | Bacteriophage |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1000155A1 (en) * | 1997-06-20 | 2000-05-17 | QUEEN MARY & WESTFIELD COLLEGE | Immunogenic fragments of toxin a of clostridium difficile |
| CA2404260A1 (en) * | 2000-03-21 | 2001-09-27 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in prokaryotes |
| WO2001094599A1 (en) | 2000-06-07 | 2001-12-13 | Smittskyddsinstitutet | Gene expression cassette and its use |
| WO2002077183A2 (en) | 2001-03-21 | 2002-10-03 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
| US20040029129A1 (en) * | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| WO2004041857A2 (en) | 2002-06-17 | 2004-05-21 | Ballard Jimmy D | Mutant of clostridium difficile toxin b and methods of use |
| WO2008152429A1 (en) | 2007-06-14 | 2008-12-18 | Health Protection Agency | Chemically modified peptides with improved immunogenicity |
| JP2011512817A (ja) * | 2008-02-28 | 2011-04-28 | スリーエム イノベイティブ プロパティズ カンパニー | クロストリジウム・ディフィシル胞子に対する抗体及びその使用 |
| WO2011060431A2 (en) | 2009-11-16 | 2011-05-19 | University Of Maryland Baltimore | Multivalent live vector vaccine against clostridium difficile-associated disease |
| AU2010325992A1 (en) | 2009-12-02 | 2012-05-31 | Tufts University | Atoxic recombinant holotoxins of Clostridium difficile as immunogens |
| CN103974718A (zh) | 2011-12-08 | 2014-08-06 | 诺华股份有限公司 | 基于艰难梭菌毒素的疫苗 |
-
2013
- 2013-09-19 MX MX2015002485A patent/MX2015002485A/es unknown
- 2013-09-19 RU RU2015106916A patent/RU2015106916A/ru not_active Application Discontinuation
- 2013-09-19 CA CA2882620A patent/CA2882620A1/en active Pending
- 2013-09-19 JP JP2015531683A patent/JP2015529677A/ja active Pending
- 2013-09-19 BR BR112015004629A patent/BR112015004629A2/pt not_active IP Right Cessation
- 2013-09-19 AU AU2013319821A patent/AU2013319821A1/en not_active Abandoned
- 2013-09-19 KR KR1020157005022A patent/KR20150056540A/ko not_active Withdrawn
- 2013-09-19 WO PCT/IB2013/058673 patent/WO2014045226A1/en not_active Ceased
- 2013-09-19 US US14/425,037 patent/US9932374B2/en active Active
- 2013-09-19 EP EP13802107.6A patent/EP2897637A1/en active Pending
- 2013-09-19 SG SG11201500980WA patent/SG11201500980WA/en unknown
- 2013-09-19 CN CN201380045505.3A patent/CN104582722A/zh active Pending
-
2015
- 2015-02-10 IL IL237172A patent/IL237172A0/en unknown
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