JP2014521605A5 - - Google Patents

Info

Publication number

JP2014521605A5

JP2014521605A5 JP2014521610A JP2014521610A JP2014521605A5 JP 2014521605 A5 JP2014521605 A5 JP 2014521605A5 JP 2014521610 A JP2014521610 A JP 2014521610A JP 2014521610 A JP2014521610 A JP 2014521610A JP 2014521605 A5 JP2014521605 A5 JP 2014521605A5

Authority

JP

Japan

Prior art keywords

vaccine

item

als3p

candida

vaccine according

Prior art date

2012-07-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 229960005486 vaccine Drugs 0.000 claims description 46
• 239000012634 fragment Substances 0.000 claims description 14
• 241000191967 Staphylococcus aureus Species 0.000 claims description 13
• 230000002163 immunogen Effects 0.000 claims description 12
• 241000222122 Candida albicans Species 0.000 claims description 9
• 229940095731 candida albicans Drugs 0.000 claims description 9
• 108090000623 proteins and genes Proteins 0.000 claims description 7
• 102000004169 proteins and genes Human genes 0.000 claims description 7
• 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims description 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 5
• 241000222120 Candida <Saccharomycetales> Species 0.000 claims description 5
• 150000001413 amino acids Chemical group 0.000 claims description 5
• 230000003115 biocidal effect Effects 0.000 claims description 5
• 241000124008 Mammalia Species 0.000 claims description 4
• 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims description 3
• 241000222178 Candida tropicalis Species 0.000 claims description 3
• 108010013198 Daptomycin Proteins 0.000 claims description 3
• 101000867232 Escherichia coli Heat-stable enterotoxin II Proteins 0.000 claims description 3
• 201000009906 Meningitis Diseases 0.000 claims description 3
• 101710116435 Outer membrane protein Proteins 0.000 claims description 3
• 241000235645 Pichia kudriavzevii Species 0.000 claims description 3
• 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 3
• 206010062255 Soft tissue infection Diseases 0.000 claims description 3
• 206010041925 Staphylococcal infections Diseases 0.000 claims description 3
• 206010066409 Staphylococcal skin infection Diseases 0.000 claims description 3
• 108010059993 Vancomycin Proteins 0.000 claims description 3
• 241000700605 Viruses Species 0.000 claims description 3
• 241000222126 [Candida] glabrata Species 0.000 claims description 3
• 239000002671 adjuvant Substances 0.000 claims description 3
• 239000003242 anti bacterial agent Substances 0.000 claims description 3
• 208000032343 candida glabrata infection Diseases 0.000 claims description 3
• DOAKLVKFURWEDJ-QCMAZARJSA-N daptomycin Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 claims description 3
• 229960005484 daptomycin Drugs 0.000 claims description 3
• 229960003983 diphtheria toxoid Drugs 0.000 claims description 3
• 238000009472 formulation Methods 0.000 claims description 3
• 230000003308 immunostimulating effect Effects 0.000 claims description 3
• 238000007918 intramuscular administration Methods 0.000 claims description 3
• 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 claims description 3
• 239000000203 mixture Substances 0.000 claims description 3
• 239000002245 particle Substances 0.000 claims description 3
• 238000007920 subcutaneous administration Methods 0.000 claims description 3
• 229960000814 tetanus toxoid Drugs 0.000 claims description 3
• 229960003165 vancomycin Drugs 0.000 claims description 3
• MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims description 3
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims description 3
• 239000000277 virosome Substances 0.000 claims description 3
• 241000222173 Candida parapsilosis Species 0.000 claims 1
• 229940088710 antibiotic agent Drugs 0.000 claims 1
• 229940055022 candida parapsilosis Drugs 0.000 claims 1
• 238000011260 co-administration Methods 0.000 claims 1
• 238000000034 method Methods 0.000 description 21
• 229920001184 polypeptide Polymers 0.000 description 11
• 108090000765 processed proteins & peptides Proteins 0.000 description 11
• 102000004196 processed proteins & peptides Human genes 0.000 description 11
• 241000191940 Staphylococcus Species 0.000 description 2
• 239000000427 antigen Substances 0.000 description 2
• 102000036639 antigens Human genes 0.000 description 2
• 108091007433 antigens Proteins 0.000 description 2
• 239000008194 pharmaceutical composition Substances 0.000 description 2