WO2006036817A2

WO2006036817A2 - Fungal variants and uses thereof

Info

Publication number: WO2006036817A2
Application number: PCT/US2005/034219
Authority: WO
Inventors: G. Todd Milne
Original assignee: Microbia, Inc.
Priority date: 2004-09-24
Filing date: 2005-09-23
Publication date: 2006-04-06
Also published as: WO2006036817A3

Abstract

Methods and compositions for treating and inhibiting fungal infections are described herein.

Description

FUNGAL VARIANTS AND USES THEREOF

TECHNICAL FIELD

This invention relates to variant fungal cells, and more particularly to uses of the cells to treat or prevent fungal infections in mammals.

BACKGROUND

Systemic fungal infections account for 40% of nosocomial infection-related deaths. Of these, infection by Candida albicans is the most common - it is the third most prevalent causative agent for hospital-acquired infections. Despite more than 50 years of modern pharmaceutical research and discovery, there are relatively few safe and effective antifungal drugs available. Even with aggressive therapy, mortality rates for systemic fungal infections remain unacceptably high at 40-70%. As a result of the high mortality rate, prophylactic antifungal treatment is desirable for high-risk patients. Prophylaxis with antifungal dugs can decrease the incidence of fungal infection. However, this approach leads to the appearance of drug resistant isolates or species of fungi. In vitro data has also suggested that prophylactic treatment with an antifungal drug such as an azole can impair the subsequent efficacy of a second drug such as amphotericin. Thus, there is a clear medical need for agents that can reduce the frequency of fungal infections without compromising available treatment options.

SUMMARY In one aspect, the invention features a method for treating or inhibiting a fungal infection in a mammal. The method includes, for example: administering to the mammal a composition comprising cells of a fungal strain or an extract thereof, wherein the cells are genetically modified (e.g., recombinantly genetically modified) to have an altered filamentation property, thereby treating or inhibiting the fungal infection in the mammal.

An altered filamentation property refers to a filamentation property which is altered relative to, for example, a wild type form of the strain; a strain which lacks the recombinant genetic modification and is otherwise identical to the strain that is administered; or to a reference strain.

In various embodiments, the cells having the altered filamentation property are hypofilamentous. In some embodiments, the cells can be genetically modified (e.g., by recombinant means) to alter the expression or activity of at least one polypeptide that regulates filamentation such that the genetically modified cells are hypofilamentous, e.g., relative to non-modified cells. For example, the cells can be genetically modified to increase or decrease the expression or activity of at least one polypeptide that regulates filamentation. The fungal cells can be of the same genus and species as the fungus of the fungal infection, or can be of a genus and/or species other than the fungus of the fungal infection. The genetic modification of the cells can include a deletion, insertion, rearrangement or mutation in one or more nucleotides of the cell. Genetic modifications include modifications arising spontaneously or resulting from mutagenic treatments (e.g., fungal cells may be mutagenized and clones of mutagenized cells may be screened or selected for clones exhibiting altered filamentation properties) and modifications introduced by recombinant DNA methodologies. The deletion, insertion, rearrangement, or mutation of DNA sequences can cause an amino acid change, deletion, insertion, or a premature truncation of a polypeptide encoded by a nucleic acid in the cell, (e.g., a polypeptide that regulates filamentation).

In one embodiment, the polypeptide that regulates filamentation is a Crvl polypeptide or a fungal homolog thereof (e.g., wherein the fungal homolog is a fungal polypeptide comprising at least 60%, 70%, 80%, 90%, 95%, 97%, 98%, or 99% identity to Crvl). In one embodiment, the polypeptide is selected from: CdclO,

Cdc24, Chk2, Chs3, Cla4, Crkl, Cyrl/Cdc35, Efgl, Erg24, Fas2, Hogl,Hwpl, Ml, Kex2, Nag5, Nikl, Pldl, Pmtl, Slnl, Sskl, Tpsl, and Vps34, or a homolog (e.g., a fungal homolog) of one of these polypeptides (e.g., wherein the homolog is a polypeptide comprising at least 60%, 70%, 80%, 90%, 95%, 97%, 98%, or 99% identity to the polypeptide). The fungal cells can be cells of a dimorphic fungus, e.g., cells of a dimorphic ascomycete. The fungal cells can be cells of the genus Candida, e.g., Candida albicans cells.

The composition can include live fungal cells, or can include primarily killed cells (e.g., wherein at least 80%, 90%, 95%, or 99% of the fungal cells of the composition are killed). The fungal cells can be killed by heat, ultraviolet radiation, mechanical disruption, or chemical inactivation. The composition can further include an adjuvant.

In various embodiments of the method, the composition is administered subcutaneously, intravenously, intramuscularly, intraperitoneally, intradermally, intraepidermally, or mucosally. In one embodiment, the composition is administered orally. The composition can be administered one, two, or more times (e.g., 3, 4, or 5 times) to the mammal.

In one embodiment, the method elicits an immune response to the fungus of the fungal infection in the mammal, e.g., a protective immune response, a cell- mediated immune response, a humoral immune response, or both a cell-mediated immune response and a humoral immune response.

In various embodiments, the method further includes evaluating the immune response to a fungus (e.g., the fungus of the infection, and/or the fungus of the strain that is administered) in the mammal, e.g., evaluating a cell mediated immune response or a humoral immune response to the fungus, e.g., evaluating a cell mediated delayed- type hypersensitivity response and/or an antibody response to the fungus.

The mammal can be at risk for infection by a fungus before the administering. The mammal at risk can be immunocompromised or at risk for becoming immunocompromised, e.g., the mammal has impaired neutrophil function, e.g., the mammal is a human with HIV, e.g., suffering from AIDS, or is taking an immunosuppressive drug.

The mammal may be suffering from a fungal infection prior to the administering, e.g., a fungal infection caused by a fungus of a genus that is the same as the genus of the fungal cells (or extract thereof) administered to the mammal, e.g., an infection caused by the same species as the species of cells administered. The mammal may be suffering from a fungal infection caused by a fungus of a species (and possibly, genus) other than the species of the fungal cells administered to the mammal.

The fungal cells may be cells further genetically modified (e.g., recombinantly genetically modified) to increase expression of a cell-surface or secreted molecule, or a portion thereof, e.g., relative to a wild-type strain, a strain that is identical but for the recombinant genetic modification, or a reference strain.

The cell-surface or secreted molecule can be a lipid, a carbohydrate, a polypeptide, or a portion thereof, hi one embodiment, the cell-surface molecule is a mannoprotein, e.g., mp58, a homolog of mp58 (e.g., wherein the comprises at least 60%, 70%, 80%, 90%, 95%, 97%, 98%, or 99% identity to mp58), or a portion of mp58 or the homolog thereof. In one embodiment, the cell-surface or secreted molecule is selected from the polypeptides of Table 9 and homologs thereof (e.g., wherein the homolog is a polypeptide comprising at least 60%, 70%, 80%, 90%, 95%, 97%, 98%, or 99% identity to the polypeptide of Table 9).

The method can further include administering cells or an extract of cells of a second fungus (e.g., wherein the second fungus is of the same genus as the first fungus, the same genus and species, the same genus and a different species; or wherein the second fungus is of a different genus from that of the first fungus). In one embodiment, the cells of the second fungus have been genetically modified to increase the expression of a cell surface or secreted molecule, or a fragment thereof. The cell-surface or secreted molecule can be a lipid, a carbohydrate, a polypeptide, or a portion thereof. In one embodiment, the cell-surface molecule is a mannoprotein, e.g., mp58, a homolog of mp58 (e.g., wherein the homology comprises at least 60%, 70%, 80%, 90%, 95%, 97%, 98%, or 99% identity to mp58), or a portion of mp58 or the homolog thereof. In one embodiment, the cell- surface or secreted molecule is selected from the polypeptides of Table 9 or a homolog thereof (e.g., wherein the homolog is a polypeptide comprising at least 60%, 70%, 80%, 90%, 95%, 97%, 98%, or 99% identity to the polypeptide of Table 9). The mammal can be, e.g., a mouse, human, goat, cow, pig, dog, cat, rabbit, rat, or horse. The method can further include isolating a composition comprising antibodies from the mammal (e.g., isolating antisera from the mammal). The composition comprising antibodies can then be administered to a second mammal (e.g, a human), e.g., wherein the second mammal is infected by a fungus or is at risk for infection by a fungus (e.g., wherein the fungus is chosen from: Aspergillus spp., Candida spp., Cryptococcus spp., Fusarium spp., Histoplasma spp., Pneumocystis spp., Trichophyton spp., Paracoccidioides spp., and Coccidioides spp.).

In one embodiment of the method, the cells are genetically engineered to decrease expression or activity of a polypeptide that alters a filamentation property of the cells, e.g., wherein the polypeptide is a gene product of a gene selected from:

SPT3; SSN6; RBFl; RFGl; TUPl; NRGl; and homologs (e.g., fungal homologs) of SPT3; SSN6; RBFl; RFGl; TUPl; and NRGl (e.g., wherein the homolog comprises at least 60%, 70%, 80%, 90%, 95%, 97%, 98%, or 99% identity to the sequence of the gene product). In another aspect, the invention features a method for eliciting an immune response to a fungus in a primate. The method includes, for example: administering to the primate a composition comprising cells of the fungus or an extract of the cells, wherein the cells have decreased expression or activity of CRVl or a fungal homolog of CRVl, thereby inducing an immune response to the fungus in the primate. The method can include other features described herein.

In another aspect, the invention features a method for eliciting an immune response to a fungus in a mammal. The method can include, for example: administering to the mammal a composition comprising cells of a Candida species or an extract thereof, wherein the cells are genetically modified to be deficient for expression or activity of at least one polypeptide that regulates filamentation growth, thereby inducing in the mammal an immune response to the Candida strain and, e.g., a second fungal species selected from: Aspergillus spp., Candida spp., Cryptococcus spp., Fusarium spp., Histoplasma spp., Pneumocystis spp., Trichophyton spp., Paracoccidioides spp., and Coccidioides spp. The second fungal species can be chosen from, e.g.,: Aspergillus fumigatus,

Aspergillus terreus, Aspergillus flavus, Aspergillus niger, Candida albicans, Candida ciferrii, Candida dubliniensis, Candida famata, Candida glabrata, Candida guilliermondii, Candida inconspicua, Candida kefyr, Candida krusei, Candida lambica, Candida lipolytica, Candida lusitaniae, Candida norvegensis, Candida parapsilosis, Candida pelliculosa, Candida rugosa, Candida tropicalis, Candida viswanathii, Candida zeylanoides, Coccidioides immitis, Cryptococcus neoformans, Fusarium chlamydosporum, Fusarium oxysporum, Fusarium solani, Histoplasma capsulatum var. capsulatum , Histoplasma capsulatum var. duboisii, Paracoccidioides brasiliensis, Pneumocystis carinii, and Trichophyton rubrum,

In still another aspect, the invention features a composition including: (a) cells of a fungus or an extract of the cells, wherein the cells are of a strain genetically modified (e.g., modified by recombinant means) to have at least one altered fϊlamentation property; and (b) a pharmaceutically acceptable carrier. The cells can be genetically modified to decrease expression or activity of at least one polypeptide that regulates filamentation. In one embodiment, the cells are genetically modified to decrease expression or activity of Crvl polypeptide or a fungal homolog thereof (e.g., a fungal homolog comprising at least 60%, 70%, 80%, 90%, 95%, 97%, 98%, or 99% identity to Crvl).

In one embodiment, the cells are further genetically modified to increase expression of a cell surface or secreted molecule, or a portion thereof, e.g., relative to a wild-type strain. The cell-surface or secreted molecule can be a lipid, a carbohydrate, a polypeptide, or a portion thereof, e.g., a mannoprotein, e.g., mp58, a homolog thereof (e.g., wherein the homolog comprises at least 60%, 70%, 80%, 90%, 95%, 97%, 98%, or 99% identity to mp58), or a portion of mp58 or the homolog thereof. The composition can further include an adjuvant, and/or an extract of cells or cells of a second fungus. In one embodiment, the cells of the second fungus are genetically modified to increase expression of cell-surface or secreted molecule (e.g., a mannoprotein such as mp58, or a homolog thereof, or a polypeptide listed in Table 9, e.g., wherein the homolog comprises at least 60%, 70%, 80%, 90%, 95%, 97%, 98%, or 99% identity to the protein or polypeptide), or a fragment thereof, e.g., relative to a wild-type strain. In another aspect, the invention features a method for treating or inhibiting a fungal infection in a mammal. The method includes, for example: administering to the mammal a composition comprising cells of a fungus or an extract thereof, wherein the cells are genetically modified to have increased production of a cell surface or secreted molecule, thereby treating or inhibiting the fungal infection in the mammal.

The fungal cells can be of the same genus and species as the fungus of the fungal infection, or can be of a genus and/or species other than the fungus of the fungal infection.

The fungal cells can be cells of a dimorphic fungus, e.g., cells of a dimorphic ascomycete. The fungal cells can be cells of the genus Candida, e.g., Candida albicans cells.

The composition can include live fungal cells, or can include primarily killed cells (e.g., wherein at least 80%, 90%, 95%, or 99% of the fungal cells of the composition are killed). The fungal cells can be killed by heat, ultraviolet radiation, mechanical disruption, or chemical inactivation.

In one embodiment, the method elicits an immune response to the fungus of the fungal infection in the mammal, e.g., a protective immune response, a cell- mediated immune response, a humoral immune response, or both a cell-mediated immune response and a humoral immune response. In various embodiments, the method further includes evaluating the immune response (e.g., to the fungus of the fungal infection and/or to the fungus of the composition that is administered) in the mammal, e.g., evaluating a cell mediated immune response or a humoral immune response, e.g., evaluating a cell mediated delayed-type hypersensitivity response and/or an antibody response. The mammal can be at risk for infection by a fungus before the administering.

The mammal at risk can be immunocompromised or at risk for becoming immunocompromised, e.g., the mammal has impaired neutrophil function, e.g., the mammal is a human with HIV, e.g., and is suffering from AE)S, or is a human taking an immunosuppressive drug.

The cell-surface or secreted molecule can be a lipid, a carbohydrate, a polypeptide, or a portion thereof, hi one embodiment, the cell-surface molecule is a mannoprotem, e.g., mp58, a homolog of mp58 (e.g., a homolog comprising at least 60%, 70%, 80%, 90%, 95%, 97%, 98%, or 99% identity to mp58), or a portion of mp58 or the homolog thereof, hi one embodiment, the cell-surface or secreted molecule is selected from the polypeptides of Table 9 or a homolog thereof (e.g., a homolog comprising at least 60%, 70%, 80%, 90%, 95%, 97%, 98%, or 99% identity to the sequence of the polypeptide of Table 9).

"Treating or inhibiting", as used herein, refers to an administering that improves a mammal's condition due to a fungal infection or decreases the severity or incidence of infection of the mammal. Methods that treat or inhibit a fungal infection may alleviate, improve, or otherwise affect the infection, the symptoms of the infection, or the predisposition toward the infection.

"Genetically modified", as used herein, includes genetic modifications induced by chemical (e.g. MMS (methyl methane sulfonate), EMS (ethyl methane sulfonate), NTG (nitrosoguanidine), or other artificial means (e.g., induced by DNA- modifying enzymes, Ultraviolet (UV) crosslinking, gamma irradiation, X-ray treatement), spontaneously-arising genetic modifications, and modifications due to the introduction of recombinant DNA episomally and/or into the genome of the cell. "Genetically modified" cells are modified relative to a wild-type or parental strain. "Recombinantly genetically modified" refers to genetic modifications introduced using recombinant DNA methodologies.

"Gene", as used herein, includes coding, promoter, operator, enhancer, terminator, co-transcribed, and other regulatory sequences associated with a particular coding sequence.

"Homolog" is a generic term used in the art to indicate a polynucleotide or polypeptide sequence possessing a high degree of sequence relatedness to a subject sequence. Such relatedness may be quantified by determining the degree of identity (e.g., percentage of amino acid or nucleotide identity) and/or similarity between the sequences being compared as hereinbefore described. Falling within this generic term are the terms "ortholog", meaning a polynucleotide or polypeptide that is the functional equivalent of a polynucleotide or polypeptide in another species, and "paralog" meaning a functionally similar sequence when considered within the same species. As known to those skilled in the art, certain substitutions of one amino acid for another may be tolerated at one or more amino acid residues of a wild-type enzyme without eliminating the activity or function of the enzyme. As used herein, the term "conservative substitution" refers to the exchange of one amino acid for another in the same conservative substitution grouping in a protein sequence. Conservative amino acid substitutions are known in the art and are generally based on the relative similarity of the amino acid side-chain substituents, for example, their hydrophobicity, hydrophilicity, charge, size, and the like. In one embodiment, conservative substitutions typically include substitutions within the following groups: Group 1 : glycine, alanine, and proline; Group 2: valine, isoleucine, leucine, and methionine; Group 3: aspartic acid, glutamic acid, asparagine, glutamine; Group 4: serine, threonine, and cysteine; Group 5: lysine, arginine, and histidine; Group 6: phenylalanine, tyrosine, and tryptophan. Each group provides a listing of amino acids that may be substituted in a protein sequence for any one of the other amino acids in that particular group. There are several criteria used to establish groupings of amino acids for conservative substitution. For example, the importance of the hydropathic amino acid index in conferring interactive biological function on a protein is generally understood in the art (Kyte and Doolittle, MoI. Biol. 157:105-132 (1982). It is known that certain amino acids may be substituted for other amino acids having a similar hydropathic index or score and still retain a similar biological activity. Amino acid hydrophilicity is also used as a criterion for the establishment of conservative amino acid groupings (see, e.g., U.S. Patent No. 4,554,101).

Information relating to the substitution of one amino acid for another is generally known in the art (see, e.g., Introduction to Protein Architecture: The Structural Biology of Proteins, Lesk, A.M., Oxford University Press; ISBN: 0198504748; Introduction to Protein Structure, Branden, C-L, Tooze, J., Karolinska Institute, Stockholm, Sweden (January 15, 1999); and Protein Structure Prediction: Methods and Protocols (Methods in Molecular Biology), Webster, D.M.(Editor), August 2000, Humana Press, ISBN: 0896036375).

In some embodiments, the sequence of a nucleic acid and/or a polypeptide will be compared to a second sequence (e.g., a second sequence from a second organism or from a related sequence in the same organism), and the homology can be determined. Homology comparisons can be used, for example, to identify corresponding amino acids. The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, which need to be introduced for optimal alignment of the two sequences. The comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm. For example, the percent identity between two nucleotide sequences can be determined using the algorithm of Needleman and Wunsch ((1970) J. MoI. Biol. 48:444-453) which has been incorporated into the GAP program in the GCG software package, using either a Blosum 62 matrix and a gap weight of 12, a gap extend penalty of 4, and a frameshift gap penalty of 5.

Generally, to determine the percent identity of two nucleic acid or protein sequences, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second nucleic acid or amino acid sequence for optimal alignment and non-homologous sequences can be disregarded for comparison purposes). The length of a test sequence aligned for comparison purposes can be at least 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 100% of the length of the reference sequence. The nucleotides or amino acids at corresponding nucleotide or amino acid positions are then compared. When a position in the first sequence is occupied by the same nucleotide or amino acid as the corresponding position in the second sequence, then the molecules are identical at that position (as used herein "identity" is equivalent to "homology").

The protein sequences described herein can be used as a "query sequence" to perform a search against a database of non-redundant sequences, for example. Such searches can be performed using the BLASTP and TBLASTN programs (version 2.0) of Altschul, et al. (1990) J. MoI. Biol. 215:403-10. BLAST protein searches can be performed with the BLASTP program, using, for example, the Blosum 62 matrix, a wordlength of 3, and a gap existence cost of 11 and a gap extension penalty of 1. Software for performing BLAST analyses is publicly available through the National Center for Biotechnology Information, and default parameters can be used.

Sequences described herein can also be used as query sequences in TBLASTN searches, using specific or default parameters.

The nucleic acid sequences described herein can be used as a "query sequence" to perform a search against a database of non-redundant sequences, for example. Such searches can be performed using the BLASTN and BLASTX programs (version 2.0) of Altschul, et al. (1990) J. MoI. Biol. 215:403-10. BLAST nucleotide searches can be performed with the BLASTN program, score = 100, wordlength = 11 to evaluate identity at the nucleic acid level. BLAST protein searches can be performed with the BLASTX program, score = 50, wordlength = 3 to evaluate identity at the protein level. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al., (1997) Nucleic Acids Res. 25:3389-3402. When utilizing BLAST and Gapped BLAST programs, the default parameters of the respective programs (e.g., BLASTX and BLASTN) can be used. Alignment of nucleotide sequences for comparison can also be conducted, e.g., by the local homology algorithm of Smith & Waterman, Adv. Appl. Math. 2:482 (1981), by the homology alignment algorithm of Needleman & Wunsch, J. MoI. Biol. 48:443 (1970), by the search for similarity method of Pearson & Lipman, Proc. Natl Acad. Sci. USA 85:2444 (1988), by computerized implementations of these algorithms (GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Genetics Computer Group, 575 Science Dr.,

5 Madison, WI), or by manual alignment and visual inspection (see, e.g., Current Protocols in Molecular Biology (Ausubel et ah, eds. 1995 supplement)).

Nucleic acid sequences can be analyzed for hybridization properties. As used herein, the term "hybridizes under low stringency, medium stringency, high stringency, or very high stringency conditions" describes conditions for hybridization o and washing. Guidance for performing hybridization reactions can be found in Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (1989), 6.3.1- 6.3.6. Aqueous and nonaqueous methods are described in that reference and either can be used. Specific hybridization conditions referred to herein are as follows: 1) low stringency hybridization conditions in 6X sodium chloride/sodium citrate (SSC) 5 at about 45⁰C, followed by two washes in 0.2X SSC, 0.1% SDS at least at 50°C (the temperature of the washes can be increased to 55⁰C for low stringency conditions); 2) medium stringency hybridization conditions in 6X SSC at about 45°C, followed by one or more washes in 0.2X SSC, 0.1% SDS at 6O⁰C; 3) high stringency hybridization conditions in 6X SSC at about 45°C, followed by one, two, three, four or more 0 washes in 0.2X SSC, 0.1 % SDS at 65°C) very high stringency hybridization conditions are 0.5M sodium phosphate, 7% SDS at 65°C, followed by one or more washes at 0.2X SSC, 1% SDS at 65⁰C. Very high stringency conditions (at least 4 or more washes) are the preferred conditions and the ones that should be used unless otherwise specified. 5 The details of one or more embodiments of the invention are set forth in the accompanying drawings and the description below. Other features, objects, and advantages of the invention will be apparent from the description and drawings, and from the claims. DESCRIPTION OF DRAWINGS

FIG. IA is a graph depicting the percentage survival of mice injected with a crvl/crvl C. albicans strain (ovals) or saline (squares), followed by challenge with a virulent strain of C. albicans. FIG. IB is a graph depicting the percentage survival of mice injected with a crvl/crvl C. albicans strain (triangles) or saline (squares), followed by challenge with a virulent strain of C. albicans.

FIG. 2 is a set of pictures showing the histology of kidneys of mice injected with a virulent strain of C. albicans (upper panels) or mice injected with a crvl/crvl strain of C. albicans followed by challenge with a virulent strain (lower panels). Gomori methenamine silver (GMS) was used to stain fungi in the tissues.

DETAILED DESCRIPTION

The invention is based, in part, on the observation that exposure to attenuated strains of fungi with one or more altered filamentation properties can protect against subsequent infections with other fungi. We have shown that inoculation of cells of a hypofilamentous strain of Candida albicans (C. albicans) protects animals from lethal challenge with virulent strains of C. albicans. Furthermore, attenuated fungi, or extracts thereof, can elicit responses that prevent or decrease disease due to infection by both homologous and heterologous strains, i.e., exposure to an attenuated Cryptococcus neoformans can stimulate responses that provide protection from infection with Candida albicans.

Attenuated fungi, or extracts thereof, can be administered alone or in combination with other fungal components such as crude or purified fungal cell wall extracts, and cell surface and secreted components (e.g., from the same or a different strain from the attenuated fungal compositions). These combinations can further promote immune responsiveness to fungi by activating innate immune mechanisms and/or by increasing the exposure of the patient or animal to protective and/or immunodominant epitopes. In certain embodiments, attenuated fungi may also have beneficial effects on subjects that have already been exposed to other fungi. Attenuated fungi or extracts thereof can be administered in combination with an antibody that specifically binds to a fungal component (e.g., a fongal polypeptide or carbohyrated) or an antigen binding portion thereof.

Attenuated Fungal Strains We have shown that C. albicans crvl/crvl mutant strains are profoundly avirulent in animal models of infection. These strains grow vigorously in vitro and are able to initially colonize mouse tissues in vivo. However, despite relatively high initial tissue cell counts, crvl/crvl strains cause relatively little tissue damage and do not kill the infected host. The avirulent crvl/crvl cells are cleared from the host tissues over a period of weeks, hi contrast to clinical isolates of C. albicans that grow predominantly as filamentous forms in vivo, crvl/crvl strains grow as ovoid, yeast form cells (U.S. Pat. Pub. 20030176367). This altered morphology may facilitate the phagocytosis of yeast form crvl/crvl cells relative to their filamentous, wild type counterparts. Transcriptional profiling reveals that the expression pattern of many of the genes associated with infection and virulence are differentially expressed in crvl/crvl strains relative to wild type controls (when grown under conditions that mimic the host environment (e.g., 37°C, pH 7, serum)). For instance, HWPl, a hyphal wall protein associated with adherence and virulence, is highly induced in wild type strains upon transfer to Yeast Nitrogen Base (YNB), pH 4.5, 30°C to YNB, pH 7, 37°C. In contrast, HWPl is not induced in crvl/crvl strains when handled similarly. However, a number of genes are similarly regulated in both crvl/crvl and wild type including PRAl, the gene encoding mp58, a conserved and highly immunogenic C. albicans cell surface protein.

Attenuated fungal strains can be generated by reducing or increasing activity or expression of polypeptides that regulate filament formation and/or invasiveness. For example, the CR Vl gene of C. albicans is required for hyphal growth and invasion under physiological conditions (U.S. Pat. Pub. No. 20030176367). Strains in which this gene is deleted, mutated, or in which expression is decreased or otherwise inhibited can be used in methods for inducing an immune response in mammals. Likewise, homologs of CRVl in both C. albicans and in other species can be targeted to generate attenuated strains. Other methods to generate attenuated strains include those in which one identifies variant cells with increased or decreased expression or activity of a polypeptide known to be indicative of filamentation (or a non- filamentous state). Such variants may arise from chemical or genetic procedures and may be due to rearrangements, deletions, or insertions in the genome of the cells. Attenuated strains suitable for the methods described herein include strains with altered filamentation properties, which can include changes in growth patterns of individual cells as well as overall changes in filament shape or structure. Relevant cell properties include, without limitation, cell volume, cell length, cell width, cell- cell adherence, axial ratio (e.g., lengthr.width ratio), budding pattern (e.g., unipolar, bipolar), and overall cell shape (e.g., round, ovoid, ellipsoid, elongated, irregular). Filament properties include, without limitation, spacing between septae, branch frequency, branch polarization (e.g., in the same or different direction relative to the main filament), planarity, type of growth (hyphal versus pseudohyphal), frequency of yeast form or non-filamentous cells within the filament, and overall macroscopic characterization (e.g., "bushy", "cables"). In general, ovoid non-filamentous cells are less able to invade substrates as compared to elongated filamentous cells. Genetic or chemical modifications can be defined as inducing/causing a hypofilamentous phenotype if they reduce cell or filament length of the fraction of elongated versus ovoid cells. The nucleic acid and amino acid sequences and GenBank^® Accession numbers and for CRVl and homologs of CRVl are provided in Tables 1, 2, 3, and 4, below. The predicted protein sequences encoded by other genes that are not homologs of Crvl, but which can also be targeted to generate attenuated strains, are provided in Table 5, with their corresponding DNA sequences in Table 6. Fungi also contain genes, often characterized as transcriptional regulators that, when mutated or deleted, cause the strain to become hyperfilamentous. In some cases, overexpression of one (or more) of these genes (e.g., NRGl) has been shown to lead to a hypofilamentous phenotype and reduced virulence. In general, overexpression of any of these genes or their homologs from other fungal species can generate hypofilamentous strains that provide protection against subsequent infection by virulent strains of the same or different fungal genera or species. The SPT3, SSN6, RBFl, RFGl, TUPl, and NRGl amino acid and nucleotide sequences are provided below in Tables 7 and 8, respectively.

Techniques common to the fields of molecular biology, genetics and microbiology can be employed for generating the fungal strains described herein. Useful laboratory references for these types of methodologies include Molecular Cloning, A Laboratory Manual, 3^rd edition, edited by Sambrook, J., MacCallum, P., and Russell, D.W. (2001), Cold Spring Harbor Laboratory Press (ISBN: 0-879-69576- 5); Current Protocols In Molecular Biology, edited by Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Struhl, K. (1993), John Wiley and Sons, Inc. (ISBN: 0-471-30661-4); PCR Applications: Protocols for Functional Genomics, edited by Innis, M. A., Gelfand, D.H., Sninsky, JJ. (1999), Cold Spring Harbor Press (ISBN: 0-123-72186-5); and Methods In Yeast Genetics, 2000 Edition: A Cold Spring Habor Laboratory Course Manual, by Burke, D., Dawson, D. and Stearns, T., Cold Spring Harbor Press (ISBN: 0-879-69588-9). Fungal species suitable for preparation of the compositions described herein include, but are not limited to: Absidia corymbifera, Absidia spp., Acremonium falciforme, Acremonium kiliense, Acremonium recifei, Acremonium spp., Ajellomyces capsulatus, Ajellomyces dermatitidis, Ajellomyces spp., Allescheria boydii, Alternaria alternata, Alternaria chartarum, Alternaria dianthicola, Alternaria geophilia, Alternaria infectoria, Alternaria spp., Alternaria stemphyloides, Alternaria teunissima , Anthopsis deltoidea, Aphanomyces spp., Apophysomyces elegans, Armillaria spp., Arnium leoporinum, Arthroderma benhainiae, Arthroderma fulvum, Arthroderma gypseum, Arthroderma incurvatum, Arthroderma otae, Arthroderma vanbreuseghemii, Arthrographis cuboidea, Arthrographis kalrae, Aspergillus clavatus, Aspergillus βavus, Aspergillus fumigatus, Aspergillus glaucus, Aspergillus nidulans, Aspergillus niger, Aspergillus oryzae, Aspergillus spp., Aspergillus terreus, Aspergillus ustus, Aspergillus versicolor, Aureobasidium pullulans, Basisdiobolus ranarum, Beauveria bassiana, Bipolaris australiensis, Bipolaris hawaiiensis, Bipolaris spicifera, Bipolaris spp., Blastomyces dermatitidis, Blastoschizomyces capitatus, Botrytis spp., Candida albicans, Candida ciferrii, Candida dubliniensis, Candida famata, Candida glabrata, Candida guilliermondii, Candida inconspicua, Candida kefyr, Candida krusei, Candida lambica, Candida lipolytica, Candida lusitaniae, Candida norvegensis, Candida par apsilosis, Candida pelliculosa, Candida rugosa, Candida spp., Candida tropicalis, Candida viswanathii, Candida zeylanoides, Centrospora spp., Cephalosporium spp., Ceratocystis spp., Chaetoconidium spp., Chaetomium atrobrunneum, Chaetomium spp., Chlamydia trachomatis,

Chrysosporium inops, Chrysosporium keratinophilum, Chrysosporium merdarium, Chrysosporium pannicola, Chrysosporium parvum , Chrysosporium queenslandicum, Chrysosporium spp., Chrγsosporium tropicum, Chrysosporium zonatum, Cladophialophora carrionii, Cladophialophora spp., Cladosporium cladosporioides, Cladosporium elatum, Cladosporium herbarum, Cladosporium sphaerospermum,

Cladosporium spp., Coccidioides immitis, Coccidioides posadasii, Coccidioides spp., Colletotrichium spp., Conidiobolus coronatus, Conidiobolus incongruus, Conidiobolus lamprauges, Conidiobolus spp., Cryptococcus neoformans, Ciyptococcus spp., Cryptoporiopsis spp., Cunninghamella bertholletiae, Cunninghamella spp., Curvularia brachyspora, Curvularia clavata, Curvularia geniculata, Curvularia lunata, Curvularia pallescens, Curvularia senegalensis, Curvularia spp., Curvularia verruculosa, Cylindrocladium spp., Dactylaria spp., Debaryomyces hansenii, Diplodia spp., Emmonsia parva, Emmonsia parva var. crescens, Emmonsia parva var. parva, Emmonsia pasteuriana, Epidermophyton floccosum, Epidermophyton spp., Exophiala castellanii, Exophiala dermatitidis,

Exophiala jeansehnei var. heteromorpha , Exophiala jeanselmei var. lecanii-corni, Exophiala moniliae, Exophiala salmonis, Exophiala spinifera, Exophiala spp., Exophila pisciphila, Exserophilium spp., Filobasidiella neoformans, Fonsecaea compacta, Fonsecaea pedrosoi, Fonsecaea spp., Fulvia spp., Fusarium chlamydosporum, Fusarium oxysporum, Fusarium solani, Fusarium spp., Geotrichum candidum, Geotrichum clavatum , Geotrichum fid, Geotrichum spp., Guignardia spp., Helminthosporium spp., Histoplasma capsulatum, Histoplasma capsulatum var. capsulatum , Histoplasma capsulatum var. duboisii, Histoplasma spp., Hortaea werneckii, Issatschenkia orientalis, Kluyveromyces lactis, Lacazia loboi, Lasiodiplodia spp., Lecythophora spp., Leptosphaeria australiensis, Leptosphaeria senegalensis, Leptosphaeria spp., Macrophomina spp., Madurella grisae, Madurella mycetomatis, Madurella spp., Magnaporthe grisea, Magnaporthe spp., Malassezia furfur, Malassezia globosa, Malassezia obtuse, Malassezia pachydermatis, Malassezia restricta, Malassezia slooffiae, Malassezia sympodialis, Malbranchea pulchella, Malbranchea sclerotica, Malbranchea spp., Microsporum audouinii, Microsporum canis, Microsporum cookei, Microsporum distortum, Microsporum eguinum, Microsporum ferrugineum, Microsporum fulvum, Microsporum gallinae, Microsporum gypseum, Microsporum nanum, Microsporum spp., Microsporum vanbreusegh, Monilinia spp., Mucor circinelloides, Mucor spp., Mycocentrospora acerina, Nectria haematococca, Nectria spp., Neotestudina rosatii, Neotestudina spp., Neurospora crassa, Nigrospora sphaerica, Nigrospora spp., Nocardia asteroides, Nocardia brasiliensis, Nocardia otitidiscaviarum, Nocardia spp., Ochrononis spp., Onychocola canadensis , Onychocola spp., Oospora spp., Ophiobolus spp., Paecilomyces lilacinus, Paecilomyces spp., Paecilomyces variotii, Paracoccidioides brasiliensis, Paracoccidioides spp., Penicillium marneffei, Penicillium spp., Penicillium verrucosum, Phaeoannellomyces spp., Phaeosclera dematioides,

Phialemonium obovatum, Phialophora europaea, Phialophora spp., Phialophora verruceosa, Phlyctaena spp., Phoma spp., Phomopsis spp., Phymatotrichum spp., Phytophthora spp., Pichia anomala, Pichia guilliermondii, Pichia ohmeri, Pichia spp., Piedraia hortai, Piedraia spp., Pneumocystis carinii, Pneumocystis jiroveci, Pneumocystis spp., Pseudallescheria boydii, Pseudallescheria spp., Puccinia spp., Pyrenochaeta romeroi, Pyrenochaeta spp., Pyrenochaeta unguis-hominis, Pythium insidiosum, Pythium spp., Rhinocladiella aquaspersa, Rhizoctonia spp., Rhizomucor pusillus, Rhizomucor spp., Rhizomucor variabilis, Rhizopus microsporus var. rhizopodiformis, Rhizopus oryzae, Rhizopus spp., Rhodotorula rubra, Rhodotorula spp., Saccharomyces cerevisiae, Saccharomyces spp., Saksenaea vasiformis, Sarcinomyces phaeomuriformis, Scedosporium apiospermum, Scedosporium prolificans, Scedosporium spp., Scerotium spp., Schizophyllum commune, Schizosaccharomyces pombe, Sclerotinia spp., Scopulariopsis brevicaulis , Scopulariopsis spp., scytalidium spp., Sphaerotheca spp., Sporobolomyces salmonicolor, Sporobolomyces spp., Sporothrix schenckii, Stachybotrys chartarum, Stachybotjγs sp., Stemphylium macrosporoideum, Syncephalastrum racemosum, Taeniolella boppii, Taphrina spp., Thielaviopsis spp., Torulopsis spp., Trichoderma spp., Trichophyton mentagrophytes, Trichophyton rubrum, Trichophyton spp., Trichophyton verrucosum, Trichophyton violaceum, Trichosporon asahii, Trichosporon cutaneum, Trichosporon inkin, Trichosporon mucoides, Trichosporon spp., Ulocladium botrytis, Ulocladium chartarum, Ustilago maydis, Ustilago spp.,

Venturia spp., Verticillium spp., Wangiella dertnatitidis, Wangiella spp., Whetxelinia spp., Xylohypha spp., and Yarrowia lipolytica.

Overexpression of Cell Surface or Secreted proteins and components Fungal cell wall components are immunogenic in mammals and can be used to enhance immune responsiveness to fungi. Furthermore, cell wall components have been shown to induce cross-species protection. Immunization with an extract containing a Cryptococcus neofonnans mannoprotein, mp65, provides protective immunity to subsequent infections with both Cryptococcus neofonnans and C. albicans (Pietrella et al., Infect Immun, 70, 6621-27 (2002)).

Cells that overexpress cell surface proteins (or fragments thereof) can be used for vaccination methods. Examples of polypeptides and their corresponding nucleic acid sequences which can be overexpressed are provided in Tables 9 and 10, respectively. These genes include the C. albicans mp58 gene and other C. albicans cell surface proteins.

One way to achieve overexpression of a nucleic acid sequence in fungal strains such as C. albicans is to express the sequence under the control of a highly active promoter, such as a promoter of one of the following genes: ACTl, TEFl, TEF2, ADHl, MAL2, HWPl, PHRl, GALl, MET3, saaά PCKl. These promoters, or others, can be further modified so as to be regulatable, e.g., by a compound such as an antibiotic, e.g., tetracycline (or a derivative thereof such as doxycycline), by the addition of tetR binding sites. Additionally, a number of promoters from heterologous species (e.g., promoters from the following genes of S. cerevisiae: ACTl, TEFl, TEF2, ADHl, GALl, GALlO and FBPl) function in a filamentous strain such as C. albicans. Compositions for administration

Strains for inoculation are maintained under a variety of conditions including on solid media or slants at 4⁰C or room temperature for short term storage or at -8O⁰C in glycerol or other cryopreservatives for longer-term storage. Exemplary Candida strains for inoculation include CAI4 (ATCC^® No. MYA-682), SC5314 (ATCC^® No. MYA-2876) and BWP17 (Wilson et al., J Bacterial, 181(6):1868-1874, 1999) and derivatives thereof (e.g., derivatives made by genetic modification (e.g. recombinant derivatives)). Live cultures for inoculations are prepared as follows. Cultures are incubated for 24 hours on appropriate agar at 37°C, inoculated into broth, and incubated at 37⁰C on a gyratory shaker operating at 165 rpm. The cells are harvested after approximately 18 hours and washed three times in nonpyrogenic saline (NPS). The final pellet is resuspended in NPS, cells are counted in a hemocytometer and diluted to the appropriate concentration in NPS. The viability of the culture can be determined by plate count. To kill cells prior to inoculation, the cell suspension can be heated at 6O⁰C for

2 hours. The lack of viability of the heated preparation can be confirmed by plating 10⁹ cells on agar and incubating them at 37°C overnight.

Fungal cell extracts enriched for cell wall components can be prepared by methods described in Staab et al. {J Biol Chem. 279(39):40737-47, 2004). Briefly, cells are suspended in a lysis buffer (50 niM Tris-Cl pH 7.4, 150 mM NaCl, 5 mM EDTA) with protease inhibitors and broken with glass beads ((425-600 microns, Sigma- Aldrich). The broken cells are centrifuged at low speed (1000 x g for 10 minutes at 4⁰C), the supernatants are transferred to new tubes and re-centrifuged at high speed (15,000 x g for 10 minutes at 4°C). The pelleted cell walls from the initial 15,000 x g spin are washed in 25 mM Tris-Cl, pH 7.5, 1 M NaCl, 0.5 mM EDTA with protease inhibitors as above. The washed walls are boiled twice for 5 min in 100 μL of SDS lysis buffer (50 mM Tris-Cl, pH 7.5, 150, mM NaCl, 2% SDS, 10 mM DTT, 5 mM EDTA with protease inhibitors at 40 μg/mL, and 0.1 mM Pefabloc) to remove noncovalently-bound wall proteins. The SDS-boiled cell walls are washed twice in buffer (25 mM Tris-Cl pH 7.5, 1 M NaCl, 0.5 mM EDTA with protease inhibitors), and suspended in 25 mM Tris-Cl pH 7.5, 40 mM 2-mercaptoethanol, 1 niM EDTA with protease inhibitors, and 75 units of Quantazyme ylg (Quantum Biotechnologies, InterSpex Products, Inc., Foster City, CA). The mixture is incubated at 37°C for 1 h with rocking and residual undigested cell wall material is removed by centrifugation at 15,000 x g at 4°C. The supernatants

5 containing the cell wall material are centrifuged at 20,000 x g for 20 min at 4⁰C before being transferred to new tubes for use.

A method for preparation of mannoprotein extracts is described in Pietrella et al. (Infect Immun, 70, 6621-27 (2002)). Briefly, fungi are cultured in a defined medium for approximately 5 days at 35⁰C. The culture supernatant (which contains o mannoproteins) is concentrated by ultrafiltration and purified by a combination of affinity chromatography (concanavalin A (ConA)) and anion-exchange chromatography (DEAE). The extract includes a mix of protein and carbohydrate. Fungal compositions can also be administered in combination with purified protein preparations, e.g., an antibody or antibodies that specifically bind to fungal 5 polypeptides or antigen-binding portions thereof (e.g., recombinant fungal polypeptides or fragments thereof), hi certain embodiments the fungal polypeptides include C. albicans mp58 mannoprotein and fragments thereof described in U.S. Pat. Pub. No. 20040142385. hi certain embodiments the fungal polypeptides include those disclosed in Table 9 of the instant specification and fragments and homologs 0 thereof (e.g., homologs having sequences at least 60%, 70%, 80%, 90%, 95%, 97%, 98%, or 99% identical to a sequence in Table 9).

Methods for Administration

Methods for treating (e.g., prophylactically and/or therapeutically) a patient at 5 risk for or having a fungal infection are provided herein, hi certain embodiments, the methods are useful for the prevention or treatment of candidiasis. The methods include administering to a patient at risk of developing a fungal infection a composition that includes fungal cells (e.g., living or killed cells) that exhibit one or more altered filamentation properties due to one or more genetic alterations. 0 Alternatively, or in combination, extracts of fungal cells are administered. Fungal compositions can be administered by conventional approaches, including administration via e.g., intravenous, intraperitoneal, intramuscular, intranodal, subcutaneous administration, transdermal delivery, inhalation (e.g., aerosol), or oral routes or via direct injection into a tissue.

Fungal compositions can, but need not be administrated with an adjuvant or a carrier. Adjuvants include, Freund's adjuvant; other bacterial cell wall components; aluminum-based salts; calcium-based salts; silica; polynucleotides; toxoids; serum proteins; viral coat proteins; other bacterial-derived preparations; gamma interferon; block copolymer adjuvants, RIBI adjuvants (available from Ribi ImmunoChem Research, Inc., Hamilton, Mont.); and saponins and their derivatives, such as Quil A (available from Superfos Biosector A/S, Denmark). Carriers include polymeric controlled release formulations, biodegradable implants, liposomes, oils, esters, and glycols.

Fungal compositions of the present invention can also include one or more pharmaceutically acceptable excipients. A pharmaceutically acceptable excipient refers to a substance suitable for delivering a fungal composition to a site in vivo or ex vivo. Excipients can maintain a fungal composition in a form that is capable of eliciting an immune response at a target site. Examples of pharmaceutically acceptable excipients are saline, phosphate buffered saline, Ringer's solution, dextrose solution, serum-containing solutions, Hank's solution, other aqueous physiologically balanced solutions, oils, esters and glycols. Aqueous carriers can contain suitable auxiliary substances required to approximate the physiological conditions of the recipient, for example, by enhancing chemical stability and isotonicity. Other auxiliary compounds include, for example, sodium acetate, sodium chloride, sodium lactate, potassium chloride, calcium chloride, and other substances used to produce phosphate buffer, Tris buffer, and bicarbonate buffer. Auxiliary substances can also include preservatives, such as thimerosal, m- or o-cresol, formalin and benzol alcohol.

The administration of fungal compositions can be performed ex vivo or in vivo. Ex vivo administration refers to performing a step of a method for administration outside of the subject, such as administering a composition of the present invention to a population of cells (e.g., peripheral blood lymphocytes) and returning the cells to the subject. Suitable dose sizes are doses capable of eliciting antifungal responses in a subject when administered one or more times over a suitable time period. A suitable single dose of a fungal composition can be a dose that is capable of effectively providing fungal antigens to a given cell type, tissue, or region of the subject body in an amount effective to elicit an antifungal immune response, e.g., when administered one or more times over a suitable time period.

The fungal compositions described herein can be administered to mammals including primates, rodents, livestock and domestic pets. Livestock include mammals to be consumed or that produce useful products (e.g., sheep for wool production). Mammals to protect include humans, dogs, cats, mice, rats, goats, sheep, cattle, horses and pigs.

Fungal infections which may be treated or inhibited by agents described herein include, without limitation: Aspergillosis, Blastomycosis, Candidiasis, Chromoblastomycosis, Coccidioidomycosis, Cryptococcosis, fungal eye infections, Histoplasmosis (capsulati and duboisii), Lobomycosis, Mycetoma, Otomycosis, Paracoccidiomycosis, Phaeohyphomycosis, Rhinosporidiosis, Sporotrichosis, Zygomycosis, Occulomycosis (including Mycotic keratitis), infection by Penicilliosis marneffei and various fungal hair, skin and nail infections (including Onychomycosis (Tinea unguium), Piedra, Pityriasis versicolor, Tinea barbae, Tinea capitis, Tinea corporis, Tinea cruris, Tinea favosa, Tinea nigra, and Tinea pedis).

In various embodiments, the compositions described herein are administered to patients at risk for fungal infections. These include patients with impairment of neutrophil function due to decreased neutrophil production in the bone marrow, increased neutrophil destruction, or qualitative defects in neutrophil function. Factors that can cause a decrease in neutrophil production include, but are not limited to (1) administration of cytotoxic drugs, including alkylating agents such as cyclophosphamide, busulfan, and chlorambucil, and antimetabolites such as methotrexate, 6-mercaptopurine and 5-flurocytosine; (2) administration of other drugs known to inhibit neutrophil production including, but not limited to, certain antibiotics, phenothiazines, diuretics, anti-inflammatory agents, and antithyroid drugs; (3) bacterial sepsis infections, viral infections such as HTV, EBV or hepatitis; typhoid, malaria, brucellosis, and tularemia; (4) primary hematologic diseases resulting in bone marrow failure, as well as both hereditary syndromes and acquired defects; (5) bone marrow failure due to tumor invasion or myelofibrosis; and (6) nutritional deficiencies such as deficiency of either vitamin B12 or folate. Factors that can cause an increase in destruction of neutrophils, thereby rendering an individual susceptible to fungal infections, include, without limitation, the presence of antineutrophil antibodies, autoimmune disease (such as Felty's syndrome, rheumatoid arthritis, or systemic lupus erythematosis), or idiosyncratic reactions to drugs that, in an idiosyncratic way, act as haptens at the surface of neutrophils, initiating immune destruction of neutrophils.

Qualitative defects in neutrophil function that can lead to increased susceptibility to fungal infections include many disease states, for example, leukocyte adhesion deficiency syndromes, neutrophil chemotactic defects, and neutrophil phagocytic and killing defects. Neutrophil function is also compromised by administration of corticosteroids used in the treatment of a wide variety of diseases. Thus, patients treated with corticosteroids are at increased risk of fungal infections.

Additional factors increasing individual susceptibility to fungal infections include: (1) treatment with broad spectrum antibiotics, especially in the hospital setting and in Intensive Care settings in particular; (2) application of intravenous catheters, particularly central venous catheters;(3) surgical wounds, particularly those associated with intra-abdominal surgeries; (4) tissue, bone marrow or solid organ transplantation; (5) cancer chemotherapy; (6) Acquired Immune Deficiency Syndrome; (7) Intensive Care Unit stay; and (8) diabetes. In addition, neonates and aged patients are at increased risk. Immunosuppressed patients (e.g., patients with acquired immunosuppression, e.g., due to HIV infection or immunosuppressive medical treatments such as chemotherapy; or with an inherited immunosuppressive disorder) can exhibit increased susceptibility to fungal infections as well.

Fungal compositions can be administered to provide a beneficial effect (e.g., a prophylactic or therapeutic effect) specific to the strain administered, or which also is beneficial towards one or more additional strains (e.g., by inducing a cross-reactive response). Thus, one may administer compositions derived from one particular strain to induce a beneficial effect in a subject at risk for infection with a second strain.

Human and animal subjects at risk for (or exposed to) infection by strains of any of the following species may be administered compositions described herein including, without limitation: Aspergillus spp., Candida spp., Cryptococcus spp., Fusarium spp., Histoplasma spp., Pneumocystis spp., Trichophyton spp., Saccharomyces spp., Paracoccidioides spp., and Coccidioides spp.

Combination Therapies The fungal compositions described herein can be administered in combination

(e.g., coformulated with, and/or coadministered with), one or more additional therapeutic agents, e.g., anti-fungal agents. Among the agents that can be used in combination therapy are polyenes (e.g., Amphotericin B (including lipid or liposomal formulations thereof), Mepartricin, Nystatin (including liposomal formulations thereof), Pimaricin, SPA-S-843), candins (e.g., Anidulafungin (also called LY303366, VER-002, V-echinocandin) Caspofungin, Cancidas (caspofungin acetate), Micafungin (FK463), and Cilofungin), aminocandins, sordarins (e.g., Azasordarin, GM 222712, GM 237354), azoles (e.g., Azaconazole, Azoline, Albaconazole, bal 8557, Bispyrithione Magsulfex Butoconazole Nitrate, Bifonazole, Butoconazole, Clotrimazole, Croconazole, CS-758, Eberconazole, Econazole, Econazole Nitrate, Enilconazole, Fenticonazole, Fenticonazole nitrate, Fluconazole, Flutrimazole, Fosfluconazole, Isoconazole, Itraconazole, Ketoconazole, Ianoconazole, Immidazoles, Miconazole, Miconazole nitrate, Neticonazole, Orconazole Nitrate, Oxiconazole, Oxiconazole Nitrate, Parconazole Hydrochloride, Posaconazole, PR-2699, Propenidazole, Ravuconazole, Saperconazole, SCH-56592 (Schering Plough), Sertaconazole, SSY-726, Sulconazole, Sulconazole nitrate, Terconazole, Thiabendazole, Tioconazole,Zinoconazole Hydrochloride and Voriconazole), allylamines (e.g., Butenafine, Naftifme, Terbinafme), morpholines (e.g., amorolfϊne), pradimicins (e.g., BMS-181184), and other antifungals (e.g., 501 cream; Acrisorcin; Ambruticin; Azaserine; Basifungin; basiungin/ECB; bactericidal/permeability- increasing protein (BPI) described in U.S. Pat. Nos. 5,627,153; 5,858,974; 5,652,332; 5,763,567; and 5,733,872; BAY 38-9502; Biphenamine Hydrochloride; Calcium

Undecylenate; Candicidin; Carbol-Fuchsin; chitinase; Chlordantoin; Ciclopirox olamine; Disodium chrmoglycat; Echinocandins (including MK-0991 (Merck);

Ethonam Nitrate; Filipin; FK 463; Fungimycin; Gentian violet; Glutaraldehyde; Hamycin; Hydroxystilbamidine; Iodine; Kalafungin; Lomofungin; Lydimycin; MK

991; Monensin; Monensin Sodium; Naftifine Hydrochloride; Neomycin

Undecylenate; Nifuratel; Nifurmerone; Nitralamine Hydrochloride; Octanoic Acid;

Oxifungin Hydrochloride; Partricin; Potassium Iodide; Prednisone; Proclonol ;

Pyrithione Zinc ; Pyrrolnitrin; Resorcin; Rutamycin; Sanguinarium Chloride ; Scopafungin; Selenium Sulfide ; Sinefungin; Thiabendazole; Thiram; Ticlatone ;

Tolindate; Tolnaftate; Triacetin; Triafungin; UK 292; Viridofulvin; Zinc

Undecylenate; Alpha interferon; Amantanium bromide; aminopyridine; amphotech; α-MSH (melanocyte stimulating hormone) peptide; BAY-10-8888/PLD-l 18; β-(l,6)- glucan synthesis inhibitors; Ciclopirox; Cyclopiroxalamine; DB-289; ECO-02301; ECO-14401; Exalamide; Flucytosine (5-fluorocytosine); Fumagiline; Griseofulvin;

Haloprogin; Iseganan; Liranaftate; Natamycin; Nikkomycin; Siccanin; Tolciclate;

Undecylenate; Undecylenic Acid; Zadaxin; beta-amino acids, e.g., PLD-118 or derivatives thereof).

The antifungal agents that are administered in combination may act, for example, by blocking ergosterol synthesis (e.g., azoles or allylamines), by interfering with the cell wall (e.g., candins), by interfering with the cell membrane (polyenes) or by interfering with protein translation (e.g., sordarins).

Fungal compositions may also be administered in combination with an antibody (or antigen-binding portion thereof) that specifically binds to a fungal component (e.g., a fungal polypeptide or carbohydrate, e.g., a mannoprotein). The antibody (or antigen-binding portion thereof) can be a monoclonal antibody, e.g., a human or humanized monoclonal antibody. EXAMPLES

Example 1. Mice are protected from lethal infection with Candida albicans by pre- inoculated with a hypofilamentous mutant strain. Experiments

Experiment #1. Fifteen Balb/c mice (female, 6-7 weeks old) were inoculated in the tail vein with 2.O x IO⁶ cells of C. albicans strain MCl 91 (crvlA::ARG4/crvlA::HIS3 ade2:: URA3/ADE2 ura3Δ::imm434/ura3 Δ::imm434 hisl ::hisG/hisl::hisG arg4: :hisG/arg4: :hisG) or saline control. MC191 is a strain of C. albicans derived from BWP 17 in which both copies of the CRVl gene were deleted using a sequential PCR mediated disruption strategy and complemented with URA3 targeted to the ADE2 locus. Fourteen days post-inoculation, mice were challenged by inoculation with 2 x 10⁶ cells of strain MC243, a virulent C. albicans strain. Survival was measured for 22 days, at which point the surviving animals were sacrificed. The results are depicted in FIG. IA. All of the mice that were pre- inoculated with saline died within 2 days, suggesting that the inoculum of MC243 was a particularly strong challenge and might obscure the magnitude of the significant difference observed. Therefore, the experiment was repeated with a lower inoculum of a different virulent C. albicans strain, CAF-2.

Experiment #2. Ten Balb/c mice (female, 6-8 weeks old) were inoculated in the tail vein with 1.9 x 10⁶ cells of strain MC191 {crvl) or saline control (8 mice). Fourteen days post-inoculation, mice were challenged by inoculation with 4.4 x 10 cells of CAF-2, a virulent C. albicans strain. Survival was measured for 28 days, at which point the surviving animals were sacrificed. The results of this experiment are shown in FIG. IB.

Kidneys were removed from both control mice and crvl /crvl pre-inoculated mice at the time of sacrifice. Colony forming units (CFU) of bacteria were determined by homogenizing one kidney from each mouse and plating the homogenate on YPD media or serum-containing plates, crvl /crvl strains were readily identified on serum plates as round colonies of non-filamentous cells while CAF-2 clones grew as invasive colonies of filamentous cells. The remaining kidney was retained for histologic analysis. Results Pre-inoculation of a crvl/crvl strain was found to confer resistance to subsequent challenge with a wild type isolate of C. albicans, as shown in FIGS. IA and IB. Survival was significantly increased in mice previously inoculated with crvl/crvl cells - either for several days (FIG. IA) or indefinitely (FIG. IB). The two experiments differed in the apparent virulence and speed of death caused by infection with a virulent strain, hi experiment #1 , crvl/crvl pre-inoculated mice survived up to 8 days while mice pre-inoculated with a saline control died within 2 days (FIG. IA). More dramatically, in experiment #2, mice previously inoculated with crvl/crvl cells showed no outward signs of infection when challenged with a virulent C. albicans strain and 100% survival throughout the experiment (24 days post-CAF-2 infection) (FIG. IB). In contrast, all of the mice pre-inoculated with saline in experiment #2 died within 9 days.

Histologic examination of kidneys from infected mice revealed striking differences between saline and crvl/crvl -inoculated groups. Mice pre-inoculated with saline had large numbers of filamentous C. albicans cells in the kidneys (FIG. 2, upper panels). In contrast, mice pre-inoculated with the crvl/crvl strain were characterized by the presence of non-filamentous C. albicans in the tissue with few or no filamentous organisms (FIG. 2, lower panels). Phenotypic characterization of fungi growing on serum plates onto which kidney homogenate was plated revealed that essentially all of the C. albicans isolated from the crvl/crvl pre-inoculated mice were in fact avirulent crvl/crvl mutants with few or no virulent CAF-2 cells observed (<1%) (data not shown).

A number of embodiments of the invention have been described. Nevertheless, it will be understood that various modifications may be made without departing from the spirit and scope of the invention. Accordingly, other embodiments are within the scope of the following claims. Table 1. Amino Acid Sequences of C. albicans Crvl

Table 2. DNA Sequences of C. albicans CRVl

Gene; DNA sequence IEQ

GenBank^® :D

Accession TO:

No . ;

GenBank® GI

No .

CRVl; ATGAATCATAAACAAGTACTACCAGAAAATGAACCGATATCAACAACAACAGCA Acc. not ACTCCATCATCATCCAATACTATGGTTCCCAACACAACTAAACAGGTTTTAAAC available; TCGTTGATTTTGGATTTTTTGGTCAAACATCAATTTCAAGATACAGCAAAAGCA GI not TTTTCTAAAGAAAGTCCCAATTTGCCTTCTATTCCTCCTTTGΆTGGATTGTTCT available CΆAGGΆTTTTTATTGGAΆTGGTGGCAAGTTTTCTTTGATTTATTTCAAGTCAGA TATGGAGACGGTAACAGTAATAATAACCCTAACAACAAGCTTTATCATGATTAT CTCAGAGTCCAAGAAACTCAΆAAACATCTTTTCΆGTCAACTTCCTCTTATΆCAG CAGCAGCAACAACAACAACATCACTTTCAACAACAACAGCAACAACAAGGGCAA CAGGGACAGCCTTTCCTGCAGCAACAGCAAAGAGGAATCGGTGTTGCTAGTGGT ATGCAAAATCAACAACATCAATTTGCCCCACAGCATCAAGGCCAACCTCAAGGA CCAGGTCAAACACCTCAACCGCCAGGTTCTGCAACTAACGCTAATTTCCCTATC AATATGCCACCAAATCTGAATCCTCAACAACAAATGTTCCCCATTAATCAACAA TTTGCTCAGATGCCAAATGGTCAAAΆTCAGCCTTCAATGGAACΆΆCAΆCAAAGA ATGGCAATGATGATGAAACAACAAGCAATGGCTGCACAAAGACAACAAATCCCA ATGAATGGTTTAGATCCACAACAACAACAGCAAATGATGAATGCTGTAGGTGGT

GACCTGGTAATTTGAATTTGCAACAACAACTATTTTTACAΆCAACAACAGCAG CAGCAGCAΆCCCAAAACTACTTTCCAGCAACAAGCACAAΆATCAAATGAACAAT TTGCGTCAACAAGCTGCAATGGTTGCTCAGCAGCAGCAACAGCAACAGCAACAG CAACAACAACAGGGTCAGTTGCAAGGCAATTTGACATCAGCAATGGGTGATTCA TCTCTGAAGAATAACTCTCCTGTTGGTGCAAGATCAAATCAACAGCTGACTCCA CAACAAAATGCTGCACCAGCTTCACTGCCACATCCTTCTCAACAAGGTCAAGCA CAAGCTCAACATAACTTCCAGAGCCATCAACAACAACAACAGCAAATGACTAAG ATGGCTGGGTCTCAAGGAATGAAAAAGAATGGTCAGATGTCAAACGGCACTAGT AATAACAGTAGTGGCAGΆAACΆATAATGCTCTACGΆGATTATCAAΆATCAATTA ATGTTATTAGAAAGACAGAATAAAGAGAGATTAGAATTTGCTAGAAACACTGGT ΆΆTTCCGACTCCAΆCCCΆTTGAGTAATGGAATGATGTTTGCCGGTCAΆAATCAA TATTCAAΆTTCAAATCΆAAΆTCAAAATCAACTTCCTCCTAATCAACAACΆACCA ACTCCAGCAACTTTCCACCCACCACCTCCGCCAACAACTGCAAATGGTCCTCAG GGACAATTTAATCAAAAACCATCACCTGCAACGTCAAACAATTCACCTGCATTA GGCAATAAATCATCACCAGCAATGGGCAATAAGAAATCGAAGAAAGAATCCAAT AGTAAAAAGGGTAAAAAGGCGAATTCAAATGCTTCTACAACAGCAAACAACAAA ACATCTGGACAAACAACACCAAACATGTCACAACCTCCTAGTGCTGGCACGGAG CAAAAGCAGCCTCAACCAACAGAGCAΆATGCGTCAATTACAAGACAAGCAACAG CGTCCAGGTTCAAATACTCCAAGTATGGGAAAGAAGGATTTCCAGCCATTGACA CCTCGCTCTGAACCAATTAGCGGTGAAACTACGAAAAAGAAGCGTAAATCAGGT AAATTGAATGACAATAATGAAAATAGTAATGGCAATTCTCCAAAGAAGCΆAGCC AΆAACCAATGCAAACTCCAAAAACTTAGATCCTΆTAΆTAAAΆGAAGAAGAGAAT GGAGTATTATCTTTGAAGAAAGAATCTTCAACTTCGTTACAAGATCAAGATCTA

[ATTTAAACCCCCCATTGGCACCAACTCAAGCCACTGCTATGTCCAATACATTT AACGACGATCCATTTGATGTTCATTTATTAGATACACAACATCATCACCAACAA AATAGCAACAACAGCAATCATAATCGTGGGCAAAΆTCTTTCAAΆTGGAAGTAA¹ AATCTCAGTGTAAGTGGCCCAGGAATGGGAATGAATAATCTGGTATTTGGTGAT TCGACTCATGCΆTTTGACATTAATTTCAACATTGATAGTCTTGATGATATATGG ACAACTACTGGACCAGGAGGTGATATTACTGGCACTGGTTCGGGTTCAGGAGG' GCTGGCGGTACCGATGATGATAACTTCATGGGAATGAATTGGGCTGCAGATCCJ ATTGAAAATGGAGAT IPF10214 ATGAATCATAAACAAGTACTACCAGAAAATGAACCGATATCAACAACAACAGCA

(Gen ACTCCATCATCATCCAATACTATGGTTCCCAACΆCAACTAAACAGGTTTTAAAC

Bank^® TCGTTGATTTTGGATTTTTTGGTCAAΆCATCAATTTCAΆGATΆCAGCAAAAGCA

CRVl) ; TTTTCTAAΆGAAΆGTCCCAATTTGCCTTCTATTCCTCCTTTGATGGATTGTTCT

AF41411333; CAAGGATTTTTATTGGAATGGTGGCAAGTTTTCTTTGATTTATTTCAAGTCAGA

310062 TATGGAGACGGTAACAGTAATAATAACCCTAACAACAAGCTTTATCATGATTAT CTCAGAGTCCAAGAAACTCAΆAAACATCTTTTCAGTCAACTTCCTCTTATACAG CAGCAGCAACAACAACAACATCACTTTCAACAACAACAGCAACAACAAGGGCAA CAGGGACAGCCTTTCCTGCAGCAACAGCAAAGAGGAATCGGTGTTGCTAGTGGT ATGCAAAATCAACAACATCAATTTGCCCCACAGCATCAAGGCCAACCTCAAGGA CCAGGTCAAACACCTCAACCGCCAGGTTCTGCAACTAACGCTAATTTCCCTATC AATATGCCACCAAATCTGAATCCTCAACAACAAATGTTCCCCATTAATCAACAA TTTGCTCAGATGCCAAATGGTCAAAATCAGCCTTCAATGGAACAACAACAAAGA ΆTGGCAATGATGATGAAACAACAAGCAATGGCTGCACAAAGACAACAAATCCCA ATGAATGGTTTAGATCCACAACAΆCAACAGCAAATGATGAATGCTGTAGGTGGT

IGACCTGGTAATTTGAATTTGCAACAACAACTATTTTTACAACAACAACAGCAG CAGCAGCAGCAΆCCCAAAACTACTTTCCAGCAACAAGCACAAΆATCAAATGAAC AATTTGCGTCAACAAGCTGCAATGGTTGCTCAGCAGCAGCAACAGCAACAACAA CAGCAACAACAACAGGGTCAGTTGCAAGGCAATTTGGCATCAGCAATGGGTGΆT TCATCTCTGAAGAATAACTCTCCTGTTGGTGCAAGATCAAATCAACAGCTGACT CCACAΆCAAAATGCTGCACCAGCTCCACTGCCACΆTCCTTCTCAACAAGGTCAΆ

CACAAGCTCAACATAATTTCCAGAGCCAACAACAACAACAACAACAGCAAATG ACTAAGATGGCTGGGTCTCAAGGAATGAAAAAGAATGGTCAGATGTCAAACGGC ACTAGTAATAACAGTAGTGGCΆGΆAACAATΆATGCTCTACGΆGATTATCAAAAT CAATTAATGTTATTAGAAAGACAGAATAAAGAGAGATTAGAATTTGCTAGAAAC ACTGGTAΆTTCCGΆCTCCAACCCATTGΆGTAATGGAATGATGTTTGCCGGTCAA AATCΆΆTATTCAAATTCAΆATCAAAATCAAΆΆTCAACTTCCTCCTAATCAACAA CAACCAACTCCAGCAACTTTCCACCCACCACCTCCGCCAACAACTGCAAATGGT CCTCAGGGACAATTTAATCAAAAACCATCACCTGCAACGTCAAACAATTCACCT GCATTAGGCAATAAATCATCACCAGCAATGGGCAATAAGAAATCGAAGAAAGAA TCCAATAGTAAAAAGGGTAAAAAGGCGAATTCAAΆTGCTTCTACAACAGCΆAAC AACAAAACATCTGGACAAACAACACCAAACATGTCACAACCTCCTAGTGCTGGC ACGGAGCCAAAGCAGCCTCAACCAACAGAGCAAATGCGTCAATTACAAGACAAG

IAACAGCGTCCAGGTTCAAATACTCCAAGTATGGGAAAGAAGGATTTCCAGCCA TTGACACCTCGCTCTGAACCAATTAGTGGTGAAACTACGAAAAAGAAGCGTAΆA TCAGGTAAATTGAATGACAATAATGAAAATAGTAATGGCAATTCTCCAAAGAAG

IAAGCCAAAΆCCAATGCAAACTCCAAAAACTTAGATCCTATAATAAAAGAAGAA GAGAATGGAGTATTATCTTTGAAGAAAGAATCTTCAACTTCATTGCAAGATCAA

'.ATCTAGATTTAAACCCCCCATTGGCACCAACTCAAGCCACTGCTATGTCCAAT ACATTTAACGACGATCCATTTGATGTTCATTTATTAGATACACAACATCATCAC CAACAAAATAGCAACAACAGCAATCATAATCGTGGGCAAAATCTTTCAAATGGA AGTAATAATCTCAGTGTAAGTGGCCCAGGAATGGGAATGAATAATCTGGTATT'

GTGATTCGACTCATGCATTTGACATTAATTTCAACATTGATAGTCTTGATGA' ATATGGACAACTACTGGACCAGGAGGTGATATTACTGGCACTGGTTCGGGTTCJ GGAGGTGCTGGCGGTACCGATGATGATAATTTCATGGGAATGAATTGGGCTGCJ GATCCAATTGAAAATGGCGATTAG Table 3. Amino Acid Sequences of Crvl Homologs

EAK92553; TSRYGKSPSVSGKSTPKPGKSPATSGKSTPHFGKSPSVSGTTTPKARSS 46433099 TPVNDPKNKPKPDSKPKNKAVNEKLENASNTKPKPKIDKKTPTEKAENK

SKSKENNTSSPKEPKGQAPTKLGSKKSPEKDKTKESSSKTGKKPESAVK SDKKQKSNVPQSYSKTKSGSKAQQTANDNKKSGANLPSSKESSLVLPPY ITKFHPSEKPKLTYDSMNEYPKEISPNVFLEDQLNNESNIIDSSNFTIS WYEDLDKKNNQFQLHIPMRPEIIDKFLSQKLKKFKKNPFSVDQAIFLIL DDEIMWSGYIATVDEIASKKGRRVKKDVIELIIMLHPWSQΆLPRTVHVS NLKILPASQPVSRVLNAMKTINNASFTRMLLGKEPIKQIDFKNFLKFQG QNLNESQKKGVQSVLNNSITVLQGPPGTGKTSTIYEIILQLLDSLNTYP

ILWAASNIAIDNIAEKLMTKHGKDILRITAAEKΞRDYNRSHPLASICL HHKMYDAMPMKYQQVMDEMKRGMAPSIGTTAYKKYAQERFFLSNQIVTQ AKVVLATPVVAGGIKSLNNVRVVIIDEATQSSEPTTLIPLALPSVEKLV LVGDQKQLSCFSLIPNLSLSLFERVLLNGTYKTPHMLDTQYRMHPΞISE FPRTKFYGGLLKDGIDANARQSEGVISSPLYFWDTKGNARΞQSVRNFLR EDGGYTYTNRDEIGYIQQVLRTLIITKGVKPEQIGIITPYSGQRDLISA TLVKDDVINPSNΞQMKTEVDIDDLKNDSKPVTIHIVSGIMIASIDAFQG REKDYMIMSCVRSNTKGVIGFLRDERRLNVALTRAKYGLIMVGDKKCLQ NGDKLWKEYLQYLDSKKAIHDNDTFGE

Hypothetical MNYQQQFLNMDSNDGQGDPGPSSMAQQNQSRFRPPFPGQPGMNAQQLAM protein LQQMSQAAQAQAGQPNQGQGRPSLTPQQIQMAMASMQAQAQAQGFNMAN

CNBA6990; MNPQALIQAMRNQQLNQNQQQGMQAGSQMGQGQGSQAQLGQQNQQQGQQ

Cryptococcus PQAQNLVGSYQPGQPHPNPTQLAFQQQRIAQLMQAQGMQARSGGPGSPI neoformans; RPPQQFPQQQQPQQRAGSMPPPPVPGQQPQQQQQQNTPFPPQQPNQQPT

EAL22930; SQSMQLSLSPAQQQMLTQQRQNLLGNPQFQSMPPQQQHALLQQQQTQYL

50260271 RMIAMQQAANQQQGGQHQPQGQSQPSPQQPQQHSTQGRRGSSQGVPQSP VIHRQPTPQQLGGTSQQPPLSGLPQHMAPPRPGSAASQRPVTPQTGQVG PGSPAIMRTPPAGGMFQQPLQHMSHSANAPSPTLSTHSHHSQQHHTPQL QQGPIMASPMHPRMDGAGTPQPGQGQGSGMNGESQGFPTQQGQHGQQPM AGPSGQDPNNSGTPYRSFRLPGPLDVRALPTLPTNYTPEQQQQVASALT LMSQAVQGQGQGQGPNQVSEGQQQGQGQFSQPPQIQPSVRPGPGSVQAP GGPGPNANMPRLPPLPLNIDTSDFPFDPRILQYLPYFGDARWRTQIQAQ NPGLFAAVQHAAGLWQTIRPΞVMQRMQAALIAMKNAAFRGTQQGIPVQS

GQPGQGQQGQQPLGQQQGLVQQQQQQQQKLQQQQQQQQQQQQQQQQQQQ QQQQQQQQQQQQQQQHQQQHQQQQQQQQQQHQQQQQQQQQQQQQQQSGQ

APSTQLGPAQLAQQAWTQQQAAQAQAQMQAHAQAQAQAQARMQAQESPV

PGSNMSPLTRPPATPHVPPVPSSPVGGRPSSSSMKDIKRDRTPSGSGSA

GQSSMPPPNFIPSHNGKPVSASGGSLEQWSATPPSATMGAASLPATAA.

ISTHTAPAHAPTSTPAVAPAPRRQSASGPSLPIKEWATALHLDIPVTKI

SPLPVNTVDEAIDPTFDGQLPPLSDKEKANIKEWLDKDVAFVAREKARQ

PRVLGKMKRWAEΞDDKGTEWWMLRKGEKRVMPQTKLRVLWPSDKERMRA

QRTHKGRRQVKFSQADLKKMAEVEDHIVPVRLELEHEGQKLKDTFMWNC

SDTWTPELFAHILCDDFAVPHQHFASRIVSAIEERVREYKDQVLPLLE

RHPKEDCQGKLDPDGDDEARAMCEVFRKAREGSGIEEEIKTDPGEEDGM

DHIRIVTFDDQVNGIDLDDERPWTVEEAMTLVPKELPQDLRILIKVDII

IGTQNLTDSFEWDIHSSVTPEΞFAASYVTELGLSMEFATAIAHDIREQI

LIYQRSLFLVGHTDSSSVILDDΞVRGAFLPPVTTTLRKEDIAMASYTPI

FNELGPDQLALLΞSQREKEMKRKKRAGRARRGIVLPEREPVKTQRTLLN

NLGPNGVPILFQADNVPVRDSAPTSRRRGAALAAEANINLLAQDLPIPA

SASPAPHLPHISARGKRLGRPPKNRAISPVSIREGPLANGGTPTTGDIK

GHRKGYLDDSADEQSINGALSASGRKKPGHYNRIPDSPSEPSTPLSGKV

ENLPSSFHLDSQTDQTSILKKRKSHNDVDERPPKSAKPDEVGVPFPISK

PASDNKIEKKKRKSSDSSGIDSDSDSGSDSGSDDSDSTFGGRKDRKKMA

AGRTETPAARSSWPTGTPGLASAASPGSGRKAIEVPMWIQRALGNMRA

KYSRDSFLVIQKPRPADQPDAPPEWRAKCNDCPGRIYALGPGETLNNFE

VHLKNKGHIGNRLAREGKTQ unnamed MSHHSTPHLHNKKTPGGVGGDNGPSASTSTNRGPMDSNTSISDSQAANA 10

LQQQQQQQFMRTQGQVPPQPGQVQGQVNQNVQGAQVAAGQAGMAQRPAG QIPQGQMPAQQGQVPPGQΆGNQΆQMMRPNMRMRPGGPQAAAPNEHLNAL IRQLQNQNPALSLEAATKLΆHVQVQRPVQKQQRVARQAQGQTPPQGQMR PGQPQGQPSPQMRSGSSTPMNMQSPQLMNVQLQQQQQQRSASPGQSPAQ QHAMLMRMNQQQQQQQQQQQNQGQTQGQNQGQGPSE

Table4. DNASequencesofCRVlHomologs

Gene; DNA sequence SEQ Organism; ID

GenBank^® NO: Accession No. ;

GenBank^® GI No.

Hypothetical ATGAATCCTGGTGTCGGTGGTCCGGTTGGAGGTGTCCAGATGGTCAATA 29 protein ATGGTTCGATGGTACCCCGTAATGATGGCAGTATGAACAATTCCCCTGA

AN9087.2; AGTCΆTGATCGGCAACCTCAACACATΆTATTTATGΆCTACTTCCTGAAA

Aspergillus CGCGGTTACCATGACTGCGCACGAGCCCTCGTCAAGGATGAATCAATCA nidulans; AGCTCAΆCACTGAACCTCCTATCAAGACAAGTCCGGGTCAΆCGCAGGGA

XM_413224; GGGCGAAGTGAATGGTGTCGACGGCGACGCGGTGATGACAGACAGTAAA

49134393 GACGGTGACAAACTGAAGATTCCCGACGACTTGCCTCGTCCCAATCTCA

ACAGCGAAAGTCΆGTCGTCTTCGTTCCTCTTGGATTGGTTCAGCCTGTT

CTGGGAGTTTTTTTGGTCCCAGCGTAAGAAAGGGAACAGCGCCGATGTG

AGGCAATATCTCCAACACACTCAGAΆTATGATGCGCATTAGAGAGCAGC

AACAAAGTCAAATGTTCCGAAΆCCAGCAACAAATGΆTGCCGGGTCAGAT

GGGGCGGCTCAACAACATGCGTGGGAACGGAATGGTCCCTCCCAACTTA

CAGAAGGCCGTCCTGCAGAATAACACTGGTGGCTTCTCCCAGCAGCAAT

ATGCGCAACTACAACAAAAGAGTCAACAGATGCAGATGATGCAGATGCA

ACGCGAGCATTCTGATATGGATATGAACGGCCACCGACCGCCCTCTCCA

TCCTCCGCCGAGAACGCGCCATCCCCGTCGAAACGACCCCGCCTTGAAG

GTGGTCCCATGAATGGGCAACAACTGGCACCCAACGGACGTGGCCAGGG

TCAGGCGATGCCTGGCCAGCAGAACCCGATGTTGATCCAGAATGGACTT

ACGCCGCGCGCGATGAACCCTAACCAGTTTGGTGCTTTTCAGCAATCGG

GTCCGGCTGCACAGCCAAAACCAATCCAGGTATATGCTCAAAACTTGGC

TCTACATCACTCTCGCTCAGCAATGAATAACCAGGGCATGCCTAATGGT

TTAATGAATCCCGGCGTGATGCCGAATCAGGCTGATCTGGTTCCCATGT

CAGΆCGGCCAGGGTATGTΆTCAGATGΆACAACGGCGAGTTTTATCCGAA

TGGCCAAATGGCGCAGGTTAGGCCTGGGGCTCAAACTCCTGGTGGCCAG

CATGGTAACCATGCTCTCCAGGACTATCAAATGCAACTCATGCTCCTTG

AGCAGCAAAACAAACGCCGACTCATGATGGCTCGCCAAGAGCAGGACAG

CATGACTCGTGGCCCCGATGGTCAACCCTTGCCTGGGCAGCAGGGCCAA

CAGCAACCGGGTCAAATGCCTCCGGGTACTTCTCCCCAGGGCAGTAGGA

CTGGGGCGTCGCCAATCCCTAACGACCAAATGAAGCGCAACACTCCCAA

ATTGAATCAATCTGGTCTTCCGAATTCACCGAACGCTCCCGACGCAATG

ATGCAGGGCCGTGGTTCTCCTGCTTCAATGAACTTCACCGGGCAACTAC

CCCCCGAAATGGCAGGTCAATTCTACATCAAGACGATGCAGGAAGGTAT

GCAGGGCGCCAACGGTATGCGGCCACCGAGCTCCAACCCGGCATTTAGT

GGCCCGCAAATGGGCCAACCAGTCCAGGCTGGCACGGCGAATCGAATGC

CGAATGGAGGCTGGCAACAACAGCCAGGTGGTCAACCTGTTGTCCCACA

ACAATCTCCGATAATACAGCCCCCAACTACCGGAACACCCCAGAGTGTG

AATTCAATGCCACCTCCCCAΆCCTCCTACAGCCAATGCCGGCCGTCAGC

CTCCTCCGTCCCCCCAGACTGGAAATGCTGCTCCCCCGACTCCGCAACC

CGCATCTAAGGCCGCGCCGAAGAAGAAAGAGACTAAGGATAGAGCCAAG CGACCAAACAAGAAGACTGCAGCTGCAGCCGCAGCGGCGGCGGCTAACA ACACGACCGCTACACCATCATCAGAGGCAGAGCAGCCACCGACTCCTAC ACCAGCGΆCGCCAATCACTCCCCAGCATCATCAATCCTTTAACAAGTCT GGTGGGAATGCCACTGCGGGCGCTCCTCCTCAGCCCACATCCGCTCCCG CTCAACAGACTCTTGTGCAGCCTCCGCCGCCTGATCAAACCCAGTCATT CAACGATCTTACCATGCCCGATCCATCTGCATTTAGCCTCGATTTCAGC GCACTGGAGAACCCGGACATCCTCGAGAATTTTGACTTCGATACATTCC TCAACACCGATACGGATACAACAGGGTTCGGGTTCGACCCAAGCATATC ATACACCGΆCGGTGTTGAGACTGGCΆCCGAGAGTGGTCTCTGA

Hypothetical ATGTCTAAACCACCACCTCAACATCAACTGAAGAATGCTAATAATTCAT 30 protein TATCACTGCCGGTATCAGATAAACAATCTAATGATTCTCGACAATTATT

CaO19.6309; ATTAGCTCATTTATATAATTATTTCAAAACTAATGGATTAGAAGAAACT

Candida GCTCAAGCATTATTAATAGAATGCAATAATACCATTCCTAAGGCAACAA albicans; CAAATTCTAAAGGTTATTCΆTTAGATAATAGTGGTCCTGATCAAAAAGA

AACQ01000214; TACATTTTTAGATCAΆTGGTGGGGGTTATTATGGTCAATTCAATCATCA

46432362 ATTAΆTCCTAATTTAAATCAAATGACAAATCCTTCAGGAATΆTTAACTC

CTCAACATCAAΆTGΆTTGTACAACAAAGAATGCTTCAACAACAACAACA

ACAGGCTCAACAGCAGCAGCAΆCAGGCTCAACAACAACAGGCCCAACAA

CAGCAΆCAACAACAACAATTGTTGCAACAACAAAGACTACΆGCAACAAG

CAATGATCCAACAACAACATCAACAACAATTGATTAATAATTTGAGTGC

TCGTCAΆCAACAAGTTGGTCTATCTACAACTACTAΆTCAAΆTGGGACCA

CCTGGTΆGTAΆTAGTAATAΆTCTTCAΆTCAAATATGTCACCAAATAATG

AACAATTACAATCACAAGCAAGATTACAACAATTGΆAATTACAATTTCA

ACAACAACAACAGCAΆCAACTTCAACAΆCΆGCAGCAACΆATTGCAATTΆ

CAGCAACAGCAACAGCAACAACAACAGCAACAACAACAACAGCAACAAC

AACAACAACAACAACAACGTCAACAGCAACGTCAACGACAAAAGAAATT

CCAACGTCAATTACTGACTCTGTCTCAAAGACTGCCAGTTATTAATAAT

GGACAACCGCAACAACAACTCCAACAAGATCAACGTCCTGCACTGGCAC

CACAΆAATCAACCTACTCCAGGAAACAACAACAACAACAACAATACTAA

TGCTGTATCΆCCGGAATTACATAGACAATCTGTTGATGATTATCΆAATG

AACTTATTACAAATGGAAAΆTCAAAΆTAATTCACAAAGACAΆΆAATATT

TGAATAATCAACAAACACGTAACTCACAACAΆCAACAACAACAACAΆCA

ACTGCAACTGCAACTGCAΆCAACTGCTGCCATTTCAACCACCAGCTCAG

CAACCTAAAAATAGTACAACAACATCAACTAATACTACTACTAGTCGAG

CACAGAAGTCCTCGAGAAAACAΆCAACCAΆAGAATTCAAGACGTCAATC

TGTTCAACAACAACAACAACAACAACCCCAGCAACAACCCCAACAATCT

CAACAAATGTCGACTTCTTCACAATCTTTTACCGCTGCTAΆTAATTCAA

ATAATGTGAATAATACATTTGATATTTCACCACAAATTCAAGATCAAGG

AATGTTATCCACCAAAGAACAACAACAACAACCCCAGCAACCGCAACCA

CAACCGCAATCGCAATCGCAATCACAATCACAΆTCTCTACCTTCAAATA

ATAACAATAACAATAACAATAAACAAGATGTTGTTAATGTAGTATTTGA

TGATGCΆTTTTTCCTGGGTAATTTACTTTTAGATGATTTTΆATGAATTT

GCCAATAGTACAAGTAATAATGGTAATGGTAATGGTAATAATGATATGA

ATTCACAATTTAATAATACACAAΆCAGAAAGAATAATGTTTAGTATGCC

ΆCCTAATCAGAATCAAAATCAΆTTTCCTTCACAATCTGGTGATGGTGGA

GGAGGAGGTGGTGGAAGTATGCAACCTAATTTTTTCGAAGGTATTGAAT

TAGGTGATGGAAATAATAGTGGTAATGGAGATGATGATGΆTGCTCCTAT

ΆΆTTACTACTGATTGGTTAAGTCTGATGGGATCAGGTCCΆGGTTATGAA

TAA

Hypothetical ΆTGTCTAAACCACCACCTCAACATCAACTGAΆGAΆTGCTAATAΆTTCAT 31 protein TATCACTGCCGGTATCAGATAAACAATCTAΆTGATTCTCGACAATTATT

CaO19.13686; ATTAGCTCATTTATATΆΆTTATTTCAAAACTAATGGATTAGAAGAAACT

Candida GCTCAAGCATTATTAATAGAΆTGCAATAATACCATTCCTAAGGCAACAA albicans; CAAATTCTΆAAGGTTATTCATTAGATAATAGTGGTCCTGATCAΆAAAGA

AACQ01000213; TACATTTTTAGATCAATGGTGGGGGTTATTATGGTCAATTCAATCATCA

46432380 ATTAATCCTAATTTAAATCAAATGACAAΆTCCTTCAGGAATATTAACTC CTCAACATCAAATGATTGTΆCAACAAAGAATGCTTCAACAACAACAACA

ACAACAACAACAGGCTCAACAGCAGCAGCAACAGGCTCAACAACAACAG

GCCCAACAGCAACAACAACAACAACAATTGTTGCAACAACAAAGACTAC

AGCAΆCAAGCAATGΆTCCAACAΆCAAC_ATCAACΆACAΆTTGATTAATAA

TTTGΆGTGCTCGTCAACAACAAGTTGG_TCTATCTACAΆCTACTAATCAA

ATGGGACCACCTGGTAGTAATAGTAATAATCTTCAATCAAATATGTCAC

CAAATAΆTGAACAΆTTACAATCACAAGCAAGATTACAACAATTGAAATT

ACAATTTCAACAACAACAΆCAGCAACAΆCTTCAACAΆCAGCAGCAΆCAA

TTGCAATTACAGCAACAGCAACAGCAACAACAACAGCAACAACAACAAC

ΆGCAACAACAACAACAACAACAACAACGTCAACAGCAACGTCAACGACA

AAΆGAAATTCCAACGTCAATTACTGACTCTGTCTCAAAGACTGCCAGTT

ATTAATAATGGACAACCGCAACAACAACTCCAACAAGATCAACGTCCTG

CACTGGCACCACAAAATCAACCTACTCCAGGAAACAACAACAACAACAA

CAATACTAATGCTGTATCACCGGAATTACATAGΆCAATCTGTTGATGAT

TATCAAATGAACTTATTACAAATGGAAΆΆTCAAAATAATTCACAAAGAC

AAΆAATATTTGAATAATCΆACAAACACGTAACTCACAACAACAΆCAACA

ACAACAACAΆCTGCAΆCTGCAACTGCAACAACTGCTGCCATTTCAACCA

CCAGCTCAGCAACCTAAAAATAGTACAACAACATCAACTAATACTACTA

CTAGTCGAGCACAGAAGTCCTCGAGAAAΆCAACAACCAAAGAATTCAAG

ACGTCΆATCTGTTCAACAACAACAACAΆCAACAACCCCAGCAACAACCC

CAACAATCTCAACAAΆTGTCGACTTCTTCACAATCTTTTACCGCTGCTA

ATAATTCAAΆTΆATGTGAATAATACATTTGATΆTTTCACCACAAATTCA

AGATCAAGGAATGTTATCCACCAAAGAACAACAACAACAACCCCAGCAA

CCGCAACCACAACCGCAATCGCAATCGCAATCACAATCACAATCTCTAC

CTTCAAATAATAACAATAACAATAACAATAAACAAGATGTTGTTAATGT

AGTATTTGATGATGCATTTTTCCTGGGTAATTTACTTTTAGATGATTTT

AATGAATTTGCCAATAGTACAAGTAATAATGGTAATGGTAATGGTAATA

ATGATATGAATTCACAATTTAATAATACACAAACAGAAAGAATAATGTT

TAGTATGCCACCTAATCAGAATCAAAATCAATTTCCTTCACAΆTCTGGT

GATGGTGGAGGAGGAGGTGGTGGAAGTATGCAΆCCTAATTTTTTCGAAG

GTATTGAATTAGGTGATGGAAATAATAGTGGTAΆTGGAGATGATGATGA

TGCTCCTATAATTACTACTGATTGGTTAAGTCTGATGGGATCAGGTCCA

GGTTΆTGAATAA

Hypothetical ATGACTAGTGAAAAGTATACCTGTTTGACATGTTCTGAACAATTTTCAG 32 protein AAGCTGGCCAΆATTCAGAAACATCTCTCGACAACTCGACACAAGTCAGT

CaO19.702; GCGATTAGAAAGTTTGGATGAGACTTTAGAATGTGAAGAATGTTCCGAC

Candida AGTAATATTCATCAGTTGTCCATTGTTAGATATGGGTTTAACGATATGT albicans; CTTTATTGTGTCAAATTTGTCTTGAGAAAGATAATAAGAAAACAGGTGA

AACQ01000183; AACACCCAGTGCTAGTTACACGCTATCAAATGGGGCATTTTTCAATAAA

46433089 CTTCCGCAGTACTTGAAATTTAGGGACATTGAATGTATGGAATGTGGAG

ATGATACCCATTTGTCTGTTGCCAACACGTCTTCTGGGCAATTAGTGAT

TTGTCGTAΆΆTGTTTACCGAAATATGAAAGTGΆTAATGTGAAATTTATΆ

AGTGAΆGATAGCGATGATTTTCTTTCTGAGTTGTTGGGGATTAAGGAAG

TGATAATCAAGAAΆTCTTCAAGAAAGAGAAAΆTCCGGGAAGAATGGTGG

TGGCAAGAGAGGGGGGAAAGCAGGAAGACGAACAAGAAAGCCAGACCCT

GATGCAGAAGCTAGAAAAGCACATTATTTACAATCTAAGCAAACGGCAA

AAGATATTAAATCTGGTACTACTGTCAAAGCTATAGGGTCAAACGGTGC

TGCTAACAΆTAAAACATCAΆCAACAGGAACAAAAAACAACACAAAGCCA

ACATCAAGGTATGGTAAAAGCCCGAGTGTTAGTGGCAAATCAACTCCTA

AACCTGGTAAGAGTCCAGCAACCAGTGGCAAGTCAACTCCACATTTTGG

TAAGAGTCCATCTGTGAGTGGTACTACTΆCGCCAAΆGGCTAGATCGTCA

ACTCCTGTAAACGACCCCAAAAATAAACCAAAACCAGATAGTAAΆCCCA

AGAACAAAGCTGTTAATGAGAΆATTGGAAAATGCGTCAAATACTAΆGCC

AAAACCAAAAATTGATΆAAAAΆACTCCTACAGAAAAAGCΆGAGAATAΆG

TCTAAACTGAAAGAAAACAATACACTGTCTCCAAAΆGAACCAAAAGGAC

AGGCTCCTACTAAGCTAGGATCTAAGAAATCTCCTGAAAAAGATAAAAC AAAGGAAAGTTCATCAAAGACAGGCAAAAAACCAGAGTCAGCAGTAAAA

TCCGΆTAAAAAACAGAAATCTAATGTCCCACAACTGTATAGCAAGACAA

AATCTGGATCTAAAGCACAACAAACTGCTAATGACAACAAAAAATCAGG

AGCAΆATTTACCGTCTTCCAAAGAΆAGTTCACTTGTACTTCCTCCGTAT

ATCACAAAATTCCATCCATCAGAΆΆAACCAAAACTTACCTACGATTCAA

TGAATGAATATTTCAAAGAGATAΆGTTTTAATGTATTTTTAGAGGATCA

ATTAAACAATGAACTGAΆTATTATTGATTCCAGTAATTTCACTATTTCT

TGGTATGAAGATCTAGATAAAAAGAATAATCAATTTCAATTACATATTC

CTATGCGTCCAGAAATCATTGATΆΆATTTTTATCGCAAAAΆTTGAΆAAA

ATTTAAAAAGAATCCATTTCTGGTAGATCAΆGCAATTTTTTTAATTTTA

GATGATGAAATCATGTGGTCAGGTTATATAGCAACTGTTGATGAAATTG

CTAGTAAAAAGGGTAGAAGAGTTAAAAAAGATGTTATTGAACTAATTAT

TATGTTACΆTCCTTGGTCACAAGCATTACCAAGAACTGTCCΆTGTTTCT

AATTTGAAAATATTACCAGCTTCACAACCAGTTAGTCGAGTATTGAATG

CTATGΆAAACTATTAATAATGCAAGTTTTΆCAAGAATGTTATTGGGTAA

AGAACCAATCAAACAAΆTTGATTTCAAGAATTTTTTGAAATTCCAAGGA

CAAΆΆTTTGAATGAATCTCAGAAAΆAGGGGGTACAΆTCAGTTCTTAATA

ATTCTATTACTGTGTTACAΆGGGCCACCAGGTACTGGTAAAACATCTAC

AATTTATGAAATTATATTACAATTACTTGATTCATTAAACACTTATCCT

ATTCTTGTGGTTGCAGCATCTAACATTGCTATTGACAATATAGCTGAAA

AGTTAATGACAAAACATGGCAAAGATATTTTGAGAATTACTGCAGCAGA

AAAGGAACGTGACTATAATAGATCACATCCATTAGCGTCAATTTGTTTA

CATCATAAAATGTATGATGCTATGCCCATGAAATATCAACAΆGTTATGG

ATGΆΆATGΆAACGAGGCATGGCACCΆTCAATTGGAACTACTGCTTATAA

GAAATATGCTCAAGAAAGATTTTTTTTGTCGAATCAGATTGTTACTCAA

GCAAAAGTTGTATTGGCAACACCTGTAGTAGCAGGTGGAATCAAATCGT

TAAATAATGTCAGGGTAGTGATTATCGATGAAGCAACTCAATCATCTGA

ACCΆACAACTTTAATTCCATTAGCGTTACCATCΆGTAGAAΆAATTGGTA

TTAGTGGGAGATCAAAAACAATTAAGTTGTTTTTCATTGATTCCTAATT

TATCATTGTCCTTGTTTGAAAGAGTTTTATTAAATGGTACTTATAΆGAC

ACCACATATGTTGGATACACAATATCGTATGCATCCAGAGATCAGTGAG

TTCCCACGGACAAAATTCTATGGTGGGTTATTGAAAGATGGCATTGATG

CCAATGCAAGACAACTGGAAGGGGTTATTTCCAGTCCACTTTATTTTTG

GGATACCΆΆGGGGAATGCAAGAGΆΆCAATCTGTTAGAAACTTCCTTCGT

GAAGATGGAGGTTACACTTATACGAΆTCGTGATGAGATTGGTTATATTC

AACAGGTGTTACGAACATTAATTATAACAAAGGGGGTTAAACCAGAACA

AATAGGTATAATAACACCATATTCTGGACAACGTGATTTGATTTCAGCA

ACGTTGGTGAAAGΆTGATGTCATCΆATCCTAGTAATGAACAAATGAAAA

CCGAΆGTTGATATTGATGATTTGAAAAΆTGATTCCAAACCΆGTTACAAT

TCATATAGTTTCTGGTATTATGATTGCATCTATTGATGCCTTCCAAGGT

AGAGAAAAGGATTATATGATTATGTCATGTGTTAGATCGAATACTAAAG

GGGTGATTGGATTTTTAAGAGATGAAAGAAGATTGAATGTGGCACTTAC

TΆGAGCCAΆATATGGTTTAATAΆTGGTAGGAGATAAGAΆATGTTTGCAA

AATGGAGATAAATTATGGAAGGAATACTTGCAGTATTTGGATTCCAAAA

AAGCTATACATGATAATGATACTTTTGGCGAATAG

Hypothetical ATGAACTATCAACAGCAATTCCTCAACATGGACTCCAATGATGGACAGG 33 protein GCGACCCGGGACCATCTTCCATGGCTCAACAGAACCAGTCGCGCTTTCG

CNBA6990; TCCACCGTTTCCGGGCCAGCCCGGCATGAATGCTCAGCAACTAGCCATG

Cryptococcus CTCCAGCAAATGTCTCAAGCTGCTCAAGCTCAGGCCGGGCAACCGAATC neoformans; AAGGCCAGGGTCGGCCGTCΆCTCACACCTCAGCΆAATACAAΆTGGCGAT

AAEYOlOO0005; GGCTAGCATGCAGGCGCAAGCTCAGGCGCAAGGGTTCAACATGGCGAAT

50260213 ATGAATCCTCAGGCGTTGATACAAGCGATGAGAAATCAGCAGCTGAATC AGAACCAACΆGCAΆGGGATGCAAGCGGGATCGCAGATGGGACAGGGGCA GGGAAGCCAGGCGCAGCTGGGGCAGCAAAATCAGCAGCAAGGGCAACAA CCTCAAGCTCAΆAACTTAGTGGGGTCGTATCAACCCGGCCAACCGCATC CAAACCCTACACAACTGGCATTTCAGCAACAGCGGATAGCCCAGTTGAT GCAAGCGCAAGGGATGCAGGCTAGATCCGGTGGTCCAGGATCGCCAATA

CGGCCGCCTCAACAGTTTCCCCAGCΆGCAGCAACCTCAACAACGTGCAG

GTTCGATGCCTCCTCCGCCTGTTCCTGGGCAGCAGCCACAACAACAGCA

ACAGCAGAACACGCCATTTCCTCCTCAACAGCCTAATCAGCAGCCCACT

TCTCAATCGATGCAATTATCCCTCTCACCTGCACAGCAACAAATGCTCA

CCCAACAACGCCAAAACCTGCTGGGCAΆCCCTCAGTTTCAGTCAATGCC

GCCTCAGCΆGCAGCACGCGCTCCTTCAGCΆΆCAACAAACTCAGTATCTG

AGAATGATTGCGATGCAGCAGGCTGCCAACCAGCAGCAAGGTGGACAAC

ATCAACCCCAAGGTCAGTCTCAGCCATCCCCACAACAACCTCAGCAGCA

CTCCACCCAAGGCCGGCGCGGTTCATCTCAAGGTGTACCCCAGAGCCCT

GTCATCCACCGCCAACCTACCCCTCAACAGTTAGGGGGTACATCGCAAC

AGCCCCCTTTATCTGGTCTGCCTCAACATATGGCACCACCGAGACCAGG

GTCAGCAGCGTCCCAAAGACCTGTCACACCTCAGACTGGACAGGTTGGA

CCAGGGTCACCAGCTATAATGAGAACACCTCCAGCAGGTGGAATGTTCC

AACAACCACTTCAΆCATATGTCCCACAGTGCTAATGCGCCCTCTCCCAC

ATTATCTACACATTCACATCATAGTCAACAACACCATACACCCCAACTG

CAGCAGGGTCCGATAATGGCGTCACCCATGCACCCGAGGATGGACGGTG

CGGGTACGCCTCAGCCTGGTCAGGGACAAGGGTCAGGGATGAACGGCGA

GTCACAAGGCTTTCCAACCCAGCAGGGTCAACATGGTCAGCAΆCCCATG

GCCGGACCATCAGGTCAΆGACCCCAΆTAATAGTGGGACGCCATACAGAT

CGTTCAGGCTTCCGGGCCCGCTGGACGTTCGTGCTTTGCCGACATTGCC

GACGAATTATACGCCTGAGCAACAACAGCAGGTGGCTTCAGCCCTCACT

CTGATGAGTCAGGCGGTTCAAGGGCAAGGACAGGGGCAAGGGCCGAATC

AAGTGTCTGAAGGTCAGCAACAAGGACAAGGTCAATTTTCTCAACCGCC

TCAGATACAACCATCAGTTCGCCCCGGTCCTGGCTCGGTTCAAGCTCCG

GGAGGTCCAGGTCCAAATGCTAACATGCCCCGGCTTCCACCCCTTCCCC

TCAΆTATCGACACTTCTGATTTCCCTTTTGACCCACGTATCCTCCAATA

TCTTCCTTATTTTGGCGACGCTCGCTGGCGTACACAGATCCAGGCCCAG

AACCCGGGATTGTTTGCGGCGGTGCAGCATGCAGCAGGACTGTGGCAGA

CTATAAGGCCGGAGGTGATGCAGAGGATGCAGGCGGCGCTGATTGCTAT

GAAGAATGCTGCGTTTAGAGGGACACAACAΆGGGATTCCAGTACAGTCT

GGTCAACCAGGTCAGGGTCAGCAGGGTCAGCAACCGCTGGGACAGCAGC

AAGGATTGGTACAGCAGCAGCAGCAGCAGCAACAAAAATTGCAACAACA

ACAACAGCAACAACAGCAACAACAGCAACAGCAΆCAACAACAGCAACAG

CAACAGCAACAGCAACAACAGCAACAGCAACAGCAACAACAACAACATC

AACAACAACATCAACAACAACAACAGCAACAACAGCAGCAACACCAACA

ACAACAGCAACAACAACAACAACAACAGCAGCAGCAGCAGTCTGGACAA

GCACCAAGTACTCAGTTGGGACCGGCGCAGTTGGCCCAGCAGGCATGGA

CTCAACAACΆΆGCTGCTCAAGCTCAGGCTCAGΆTGCAΆGCCCATGCTCA

AGCACAGGCTCAAGCACAAGCCCGAATGCAAGCACAAGAGTCTCCAGTG

CCAGGAAGCAACATGTCCCCTCTCACTCGCCCTCCCGCCACACCCCATG

TACCGCCTGTGCCCAGCTCCCCTGTCGGCGGCCGACCGTCCAGTTCAAG

TATGAAGGATATTAAACGAGATCGCACGCCTTCAGGTAGTGGATCGGCT

GGTCAGTCTTCAATGCCGCCGCCCAΆCTTTATACCTTCΆCΆCAATGGAA

AGCCAGTGTCAGCATCGGGAGGATCACTGGAGCAAGTCGTCAGTGCTAC

TCCTCCCAGCGCTACTATGGGTGCTGCCTCACTCCCGGCAACAGCTGCT

ATCTCTACTCATACTGCTCCTGCTCACGCTCCTACCTCCACGCCCGCAG

TGGCGCCCGCACCCAGGCGGCAATCCGCGTCTGGTCCCAGTCTCCCCAT

CAAAGAATGGGCCACCGCCCTTCACCTCGATATCCCAGTTACCAAGATC

AGCCCTCTCCCTGTCAACACCGTTGATGAAGCTATCGACCCAACCTTTG

ACGGGCAACTGCCTCCGCTCTCAGATAAGGAGAAGGCCAACATCAAAGA

ATGGCTCGATAAGGATGTGGCATTTGTGGCCCGAGAΆAAGGCCAGGCAA

CCGAGGGTGCTGGGAAAGATGAAAAGGTGGGCGGAΆGAGGATGATAΆGG

GTACAGAATGGTGGATGTTGAGAAAGGGTGAGAAGAGAGTGATGCCGCA

GACAAAGTTGAGGGTCCTTTGGCCGAGCGATAAGGAGAGGATGAGAGCA

CAAAGAACGCATAAGGGAAGGAGGCAGGTCAAATTCTCCCAAGCGGACC TTAAAAAGATGGCAGAGGTCGAGGATCACATTGTGCCTGTCAGGCTGGΆ

GTTAGAGCACGAAGGGCAAAAGTTGAAGGACACTTTCATGTGGAACTGC

TCTGATACTGTTGTGACCCCTGAGCTTTTTGCCCATATCCTTTGCGACG

ACTTTGCCGTTCCCCATCAACATTTTGCGTCCCGTATCGTCTCCGCTAT

CGAAGAGCGTGTCCGCGAGTACAAAGATCAAGTCCTTCCTTTGCTTGAG

CGTCACCCCAAAGAAGATTGTCAAGGCAAGCTTGATCCCGATGGTGACG

ATGAAGCTCGTGCGATGTGTGAAGTCTTCCGCΆAAGCTCGGGAΆGGAAG

CGGCATTGAGGAGGAAATCAAGACCGATCCAGGAGAGGAGGATGGAATG

GACCACATCAGGΆTTGTTACCTTTGATGATCAAGTGΆΆTGGGATTGATT

TGGACGATGAGCGACCATGGACAGTGGAAGAAGCCATGACCTTGGTGCC

AAAGGAGCTGCCCCAGGATTTGAGGATATTGATCAAGGTAGACATCATT

ATTGGTACCCAGAACTTGACGGATAGCTTTGAGTGGGATATTCATTCTT

CGGTTACTCCAGAAGAGTTTGCGGCGTCTTATGTCACTGAGCTGGGCTT

GAGCATGGAATTTGCGACCGCTATCGCACACGATATTCGCGAACAGATC

CTCATCTΆTCAACGTTCCCTCTTCCTTGTCGGCCACACTGATAGCTCTT

CTGTTATTCTTGACGACGAAGTGCGCGGCGCCTTCCTGCCTCCTGTCAC

TACCACTCTTCGTAAAGAAGACATTGCCATGGCATCGTACACACCCATC

TTCAATGAGCTTGGTCCTGATCAGTTAGCATTGCTCGAGTCACAGCGAG

AGAAGGAGATGAAGCGCAAGAAGAGAGCTGGCCGTGCTAGACGCGGTAT

CGTACTTCCTGAAAGGGAGCCCGTTAAGACCCAACGCACTTTGCTCAAT

AACCTCGGTCCCAΆTGGAGTTCCGATTCTGTTCCAAGCCGATΆACGTCC

CTGTCCGAGACTCTGCTCCTACCAGTCGAAGGCGTGGTGCTGCTCTCGC

CGCAGAGGCAAACATTAATCTCCTGGCTCAAGACCTTCCTATTCCCGCA

TCCGCGTCTCCTGCTCCTCATTTΆCCTCATATCTCTGCCCGGGGCAAGC

GCCTTGGTAGGCCCCCTAAGAACAGAGCAATAAGCCCTGTTTCTATACG

AGAAGGGCCTCTTGCCAATGGCGGTACACCCACCACAGGCGATATCAAA

GGCCATAGGAAAGGATATCTGGΆCGACTCAGCGGATGAGCAGTCCATCA

ATGGAGCACTGAGCGCATCCGGGAGGAAGAAGCCCGGTCATTATAATAG

AATTCCCGATTCACCTTCTGAACCCTCTACTCCTCTCTCCGGCAAGGTG

GAAAATCTCCCGTCATCATTTCΆTCTAGACTCGCAAACCGATCAGACTT

CGATTCTCAAGAAACGCAAAAGTCATAATGACGTTGATGAACGACCACC

GAAGTCTGCCAAGCCTGATGAAGTCGGAGTGCCATTCCCGATTTCCAAA

CCCGCTTCTGACAATAAGATCGAAAAGAAGAAAAGGAAGAGTTCCGATT

CTTCTGGCATCGATAGTGATAGTGATAGTGGCAGCGACAGCGGGAGTGA

TGACTCAGACTCAACTTTTGGCGGAAGGΆAAGATAGGΆΆGAAΆATGGCG

GCGGGCAGGACTGAGACGCCTGCAGCAAGGTCCTCTGTGGTGCCAACTG

GAACTCCAGGCTTGGCGTCGGCTGCATCTCCTGGCTCGGGAAGGAAAGC

TATCGAAGTTCCGATGTGGATTCAGAGAGCTCTCGGTAATATGAGGGCA

AAATATTCTCGAGACTCGTTCTTGGTCATCCAAAAGCCCCGGCCGGCGG

ATCAACCAGATGCGCCTCCAGAGTGGAGAGCCAAATGTAATGACTGCCC

AGGTCGAATCTACGCTCTCGGTCCCGGTGAGΆCTCTCAΆCAATTTTGΆA

GTCCACCTCAAAAACAAGGGCCACATCGGCAATAGGTTGGCAAGGGAAG GGAAGACTCAGTAA unnamed ATGAGTCATCATAGTACTCCACACTTACATAATAAGAAAACGCCTGGGG 34 protein GTGTTGGAGGCGATAATGGGCCCAGCGCATCAACATCCACAAATAGAGG product; GCCGATGGACTCGAATACAAGTATCAGTGATTCACAGGCTGCGAATGCG

Debaryomyces AAGCAGCTCTTGAACGCTTACGTGTATGATTTTCTTATTAAGAGCAGAC hansenii; TCCCCCAAACAGCGAGAATTTTTGTCAACGAGGCAGAGGTTCCGTCGAT

CR382133; CCAAAACAGCTCGGCGAGCTCAAATAACAATTCGCCGCGTCAGGTGAGT

49651994 ACTGGTAATACAAAGGGTACTTCTAACGAGTCCACACCCCATACACCCA GTGGTGTTTCCCAACAGTTTCCGAΆGGAAAATAACTTGCCΆTGTTTGGC GTTGGCAATGGAAGCACCCCAGGGGTTTTTGTTCGAATGGTGGCTGATA TTCTGGGACGTGTTACAAGCGAAGAΆTAATAAAGGTGGATCCCΆGTTGG CGGCGCAATACTACCAGTCCCΆGATGTTAAAGCAAΆGΆCAGCAGCAGGA CCTTCAAGGGTTGΆATATGCAGCCTAATATGTTCGGACCCGCAAΆTGGG CAAATTCAACAGCAAATGCAACAGCAGCTAAAATCATCGATAGATCAAC

ACAACCACAGCAGCAGCAGCAGCAAACACΆACAACAAACACCACCACCA

CAACAAACACCACCACAACAACAAGCACCACCTACTCTACAAAAΆCCAA

AGCCACAGCAATCACAGCAGCAACAGCAACAACAATCATCACCATCACA

ACCACAACATCATCAGCAACCCCAAGCACTACCACCCGCGCCACTACCA

CAAGCΆCCAGAACCAGCACAGCAACATTCGCAACAACCTCAACCTCAAC

AACAACCCCAGGCGCAACAGGCAAAATCACCTTCGCAGCAGCATCATCA

ACAGCAAGCGCAAGCGCAAGCACAACAGCAGCAGGATTCACAACAGGAA

GCACCGCAAACACACACACAGATACAAGCACAAGCACAAGCACAAGCAC

ACGCACACGCACACGCACAAGCACAAGCACACGCACAAGCACAAGCACA

CGCACAAGCACAAGCACAAGCACAAGCACAAGCACAAGCACAAGCACAA

GCACAAGCACAAGCACACGCACAAGCACAAGCACAAGCACAAGCACAGT

CACAGTCACAGTCGCAGCCACAAGCACAAGTΆCAAGCACAATCTCAGGC

AGCACAAGCACAAGCACAAAATCAGGCGCAGCAGACCCAAGTACCCCCT

CCACAGCATGCGCAGCAACAGCTACAATCGCAGCCTCAGCΆATTGΆΆGA

AGΆATATTCAACTTCAGGAGATGCAGCAGCTACATGCCCAGCAGATGGT

ATACCAAATGCAAAGTCAACAACAGCGACAGGTATCTAATATCCAAAAG

CGCCCCCGCAGGCCAAAGCGGGAATCACCTCAAAGGATATTGGAATCGC

CCAAGAAGAAGGGCCATCTCTCGGTTCCGGCGATGCCGGCGATGGCTAG

CTTGACTGCGAGTACAGGCCCGGGCTCGAGTCAGCTGAAAAAAATGATG

CCAAACAACTTAGAGAAGATAGAAATTAAAGGCCAGAAAACCAACACTC

AGCAAGCCCAGCTCAACTGGACCAAGCTACAGCAACAACAGCTGCAACA

ACAGGTACAACAAAAACAGGAGCAACATCAGGATGAGCTTGAGCAACAG

CATCAACAACAACATCAAGAAAAAGAGCAAGAGCAGCATCAACAGCAGC

ATACACCAAATCATCAGTTGCAGCTGGACAAACAATCTCAAGATCAΆCT

GCAACAGAAGTCCAATATTGAGGGCGGGACGGAGGCACAGCCGCAACAA

CAAACCCCACAAAGCGCTACGCCTCAACCCCGCCAGCTCTCTCAGCACC

AGATACAAGCGCACCAACAACTATCGCATGATΆCCAAAGCAGAGGΆGCA

GTCTCTCACTGAGCATCAAAAGGCTGAAGAAGCTACTCCCAAAAGAGTG

CAGCAGGTCCAGTTTACGCAGGCGTCCCTGCATATTCAGCCTTCGGCCA

TGATCCGGGATGACCATATGGTACAGGAGTCCGAGAAGGAGCAGGAACC

TCAAAGTCAAAAGCATCATCTTCATCATCCGAACAATCAGCAGCAATTG

ACGGATCCCACGCCGGCTAGGGGTCAGCCGCCACCACAATTACATCCAG

AACAGCAGCAAAGASAGCAGGGGTCGCCCATCCGAACATCACAGCCGCA

GGGACAGGCATCGCATCTGAAGCAGCCATTACGGAAACCATCGCATCAG

TCACACAATCAGCCATCGTACCTCGCCCAGAACATGTCCCAGAGCCAGG

GCCTGCAGCAGCTGGATTTTATGAACCCAATGTCTATGATCCCACCGGT

TCGGGCTGCAACGGCGGGCAATATCTCCGTACAGCCCATCGCCGAATCG

TCATCAGCCGCTAGCCAGCACCACGTGATGTCAACTCCTTATGGGCCTG

CGGGTGTTAACCCAGAAGTCGATGGGCTCGATCCTCTTTTTTTCCAGCA

GCAGGTGCGCTTTCCAGGCTCCATCTTAGACCCTGCCATGTTCAAGACT

CCGGCATACGCACAGCTCTCGTCACAGGCAAGTAGGAAAAATCCACCGG

ATAACGTCTCCGATAAΆAAAGGTCGTAΆGCAGACAGGTGCGTCCTTTCA

GCCTGCGCAGGACGGTCTGCAGTCTGTTCAGGACATGAACACCATCTTG

CCTGACACTTCTTCGCAAGATCGAGCCGAGGACCAAAGCCTCAGTACGC

CTCTGAACATGGACATGGATTTGGACCACTTCGATATCACCGTCTTTAA

CAATGACTTTATGGGCTCGTGGAΆGTGA

AGL300Cp; ATGGTGGAGAACAAACAGCTACTGAATTCGTACATATACGATTTCCTAA 36 Eremothecium TAAAATCATCGCTCGAAGAAACGGCCGAGCTGTTCAAGCAGGAGGCGGG gossypii; CGTGCCGGATGGGCAGCCGGACATGGΆCGCGCCGCACGGGTTTCTGTAC AE016905; GAGTGGTGGCAGATCTTCTGGGACATCTTCAACGCTCGGACCCACCGGG 44985424 GGGGCTCGGACCTGGCGCAGCAATACTTCCAGATGCAGCTGTACAAACA GCGGCAGGAGCATGCGTACCGGGGGATCGCGATGCACGCGGCACGCGTG CAGCGGAAGGCGGAGCAGCGCGGAGAGTATGCGCAGGAGATGTTCGACC GGGTGCTGTTTTCGATGATGGCGATGAACTCACΆAΆGCGCGGGCCTGCG GGGCGGCAGCCAGCAGGCGGCGCACGCGGTGCGCAGCGCTCCATACGCC GCGCCTGGGCCGTACACGCCGCAGCAGGGCATGACGGCGCΆCTACGCGG GGGGGATGGCCAGCGCAGTCGGTCAGCCTTCTGGTAAGGTGCCCCCGGT

GGTGGCCGGCCCGGCGTCGTACTGCGTCCACGCAGCGCTCTCTCCGCTC

CAGATGATGGGGGGGCTTGCGCAAGTCCCAGGCGGTATGATTTCGCTAC

CGGAGCAGCTGGΆCGGGCAGCGACAGGTAGATCCGCAGCCAΆCTCCACC

GATGACCGTGTCGCCTAGTGGCACTATGGGCCAGGGTCAGGGTCAGCAT

CGCGGCCCGATATTCCΆGAATCΆGCCGGCTCTGTATCCATACΆACGTTG

CAGGCΆCCATGTATCCAATGCAGCAGCTΆTCGCCAATGGCGCAGCCTTT

TGTGCATTCCCAGGTGATGCCAATGTCGATGTCTTCTGGTGCGGCGACG

CCΆGTTGGCCGACCCGCCTCGGCCACCTCCGCCAACCCTCCCACACAGC

GTAGACGCAAGAGGTCGCAGCAGCAGGCTCAGCAGCAGGCTCAGCAGCA

GGCTCAGCAGCAGGCTCAGCAGCAGGCTCAGCAGCAGGCTCAGCAGCAG

GCTCAGCAGCAGGCTCAGCAGCAGGCTCAGCAGCAGGCTCAGCAGCAGG

CCCAGCAGCAGGCCCAGCAGCAGGCCCAGCAGCAAGCTCAACAGCAGGC

TCAACAGCAGGCTCAGCAGCAGGCTCAGCAGCACGCCCAACAGCACGCC

CAGCAGCACGCTCAACAGCAGGCTCAACAGCAGGCCCAGCAGCAGGCCC

AGCATCAAGCCCAGCAGCAGGCCCAGCGGCAAGCCCAGCATCAAGTCCA

GCATCAAGTCCAACAGCATGCCCAGCΆTGCCCAGCATCAAGCTCAACAG

CATGCCCAGCATCCAATGCAACCGCACGTCCAGCAGCAΆCACTCGCATT

TCCCCCAGCAACAACACCACCGCCACTCACAACAGCTACCAATGTCGCA

CCTTCAACΆTTCTCAGTCACAGTTACAGCAGCGATCACAAATACACCAT

GCACCTCCTCATCAACAGGTATCGTATCCACCGCAACCTTTAAAGCAGC

AGCGACATGCGTCCCTTCCACAGCTTCCCGΆGGCTCAGAACCTGTATGC

ACAGCACCATCCTATACAGCAGGATTCACAAGCGCAGGATAGACCGGAC

TCACGACATTCTAGTATGGACAAAGACTTTACCAΆCGCTGACGGCTTGC

ATAACTACCGCAGGCAGCTAATATTACTAGAGAGGGAAAACAAAAAGGC

AATTTCTGCTCCTCCGCGGGACGTCCAGTCTGCCTCGAGCACGCCGCTC

ACCAGCCCACAGGTGCTCCATCGCTTCAACCACAGCATGTTACCACCGT

CTTCCGTGATATCCCCACAGACCAGCGGTAGTCCCAACCCCGTAGCCAT

GCAAATGTCTGCGATGACGGGAAGTATCGGTATTGTGGGCGCACCAACA

GCAGCTACCCAGAGCTCCGCGGGAGCAACTGCTGTAAAGAAAAGAAAGT

TCACTAGGCGAAAGGTTGATAGCACGAAAAGGTCCCTATCGGAGCCTAA

TTCTCCTGCAACACCGATAACTCCCTTCACAAGCAGTACACTGACATTA

GCAΆGCACCTTAACCACCGTCACCGAGCATCCGCAGCACGAATTAAGCT

CTGCGTTGCTTGAGGAGGATGAGCGCAAGAAAAAGAGGCCTAGAAAGTC

ACTGTCAGTTCATCCCACTCCGCCGTTTTCCACCGATAGCCTGATGGAA

ACTGTCCCTTCGGGTAATGCTAACATAAAGAAGAACTCTCATGCATCTT

CCGTAACGGCTGCAGTTTCCGGTGCAGTTTCCGGTGCAGTTTCTATGAA

CAAACTAAGGATGAACGGAAAGAAAGCTATGGGTGTACCCTCCAACAAA

AAGGCACCAGCTCCATCTGGCACTGTGCAGTATGCGGCCCCCCCGGGCG

TCATCACTGCCGCAGCACCCTTTGCTGCTGTTCCCACGGCCGAGGATCT

GCTCAGCGGCAGCAGTGCAAGCACTGAATCCGTTGCACACATGCTGCCA

TTGGGGCCTAACAGCAGCGGACTCAGTCCCAGCCATGGTACCGGCCTGG

ACACTCTCCACGACGACCCTACCCTAAGCGGCGATGTGCCCTTCCAGTT

CGATCAGGAGGATGCCGACCTGCTCGCATCCGTTAAAAAΆCCCATCGAT

GTTGΆCGTCATCAACTCGGCCΆTCAGCACCGACACCGCCAACCCTGGGT

CCGCCGCGGGCTCGCTTGCGGCCAGCGTCACAAACCCGAAGGACCAAGA

CACTTTCAATCTCGACTTTTCCGATCCAAATTCCAATTATAATGACTTC

AACTTCTTCCAGTTCAGCTGGCGCTGA hypothetical ATGTCAAACACAAACGACGAGATTCAACCTCAGGCAACCTCAGCCGATG 37 protein CTGAGATGTCAAACΆGGGGTCAGTCATCTCGAGAGGAGGGAACAAGCTC

FGO1527.1; CAAAAAGGGTCGCGGCCTCCTCAAGGTTCCTTCGAGATCATCGTCACAG

Gibberella CGGAACCAATCGTCACCAACATCGΆCTGGGCTGAGTGGGGCTΆCAGTCA zeae; GCGATCCCCGAAACAGTATCGGAAGCCGATCGAAGGAGTCTAAAGGAAG

XM_381703; TCTCCGGGCGCGACGACGGAATGGAAGCACCTCAAGCAACAGGACAGGA

46109289 GGTGAAACCGAGCCTΆCAAACACTGCGGTAAACTCCCAGCAAAACTCCA CTGCCGCCCCCCCTCAAAAGAAGAAGCGTGGTGGTCTTTTCGCCTTTCT CGGATGCTGTGGTACGCCCGAAGGTCCAGCTGGCAACGAGGAAAACAAC

GAGAACGTGCACAAGCTCGACGTCCTACCTCAACGCCCGACATCCGCAA

GGTCGCGAACCAATACTCCCCAGGAACAACCCAGGCCAGTTACCGCGAG

AGAGTCTCAAGTCACCGTTCCCGCCCCGGAGCCCAAGGAAGAGGCTACC

TCATCAGGCCACGCCCACGACGAAATCACAACGACAGAGCGAGAAAACA

GGGAATCGAAACAATCGGTTCCCCCTTCAGTCACAGTGGATCCTCCCAA

GCCTACTCCCACAGAAGΆTGAGCCTCACGTGGCAGACAAGΆCGCCCAAC

AGCGGTGACGTGGATATGCGAGATGCTGCCACTGAGGAGCCTGAGGAAG

AGGCGGCTGTAGCCCCTGCAGTCGAAGCTCCAGCCCAAAGGACGATACC

ACCTCCCCCACCCCCGGCTGTCGTGGCACCCAGTCAATTCACGGATGCA

GGCCCCTCAGCGCCCGAGCCGCAGAAGTGGTTGTTGCCCCCGATTGCAC

CAGAGCACAAGGGTAGAAAΆTGTCTGGTCCTCGΆTTTGGATGAGACTCT

GGTTCACAGTTCCTTCAAGATCCTACACCAAGCCGACTTTACAATCCCT

GTCGAGATTGAGGGTAACTACCACAATGTGTATGTGATTAAGCGACCAG

GTGTCGACGAGTTCATGAAGCGAGTTGGCGAGCTCTATGAGGTCGTCGT

CTTTACAGCTTCTGTCTCCAΆGTATGGAGATCCGCTATTGGACCΆGCTC

GATATCCACAAGGTTGTCCACCATAGACTCTTCCGTGAGAGCTGCTACA

ACCACCAAGGAAATTACGTCAAGGACTTGTCCCAAGTTGGCCGAGACCT

GAAGGATACCATCATTATCGATAACTCGCCCACCTCGTACATCTTCCAC

CCACAGCACGCCGTGCCCATCAGCAGTTGGTTCTCTGATGCCCACGACA

ACGAGCTACTAGATCTCATACCCGTCCTCGAAGATTTGGCCGGACCTAA

TGTCGCCGACGTCAGCCTTGTTCTTGACGTCACACTCTGA

Hypothetical ATGTACTCCGCCGGCTACAACTTTGGCAACAATGCTGCTCCCTCTTTCA 38 protein ACAACCCTGCCCCACAGCAGCAATCTGGAGCTCAGCCAGCCGCTCAACA

FG09637.1; GATGATGTATAACCAGCAGCAGCAGTTCGCCGGTATGGCTCCGCAGGGA

Gibberella GGCTTTAATCCTGGCGCGAATCCTCAAATGATGGCTGGTGGTCCTGGAG zeae; GTATGATGCCCAACGCAGGCATGCAACATATGGCTGCCAATAGTCAAAT

AACM01000398; GGCAGGATTTCAGCAGCAATTCTCCGGTAACCCGTACGGCCAAGTCGTT

30475272 CCCTCCTCGGTCGCTCCTCAAAGCTTCΆCGCCAAACTATATGΆTGGGTG

GAGGCATGCAAGGCTTTCCGATGAACCAGGGCGGTATGCCCCAACAACC

CCATATGATGCAGCGAATGCAACAGCAACAGCAACAGCAACAGCAACAA

CAACAACAGCAACAGCAACAGCAACAGCAACAGGCACAAGCGCAGGCAC

AAGCGCAGGCACAAGCGCAGGCACAAGCGCAGGCACAGGCACAGGCACA

GGCACAGGCGCAACAGCAGCAGCAGCAGCΆGCAGCAGCΆGCAAGCTGCT

AACGCCGCTGGTATGGGCCAGGTCTCTACTCCGCAGAGACCCCCAAGCG

CAGCACAAGGGACACCAAACAATGCCTTGCCATCTCAACAGGGCCAATT

CCCGACTCCCCAGCAGCCACCGCAGAGTCAAΆCTCCCACAAACCACCAG

CAACAGCΆGCAACAACGACAΆCAGTCGCAACCTCCACAACTACAGCAGC

AACAGCCCCAGCAACCGCAGGGGCAAATGCAGGGACAGGTCCAGCAACA

ACAACCGCCTTCGGCTTTAACAACACCTCAGACTCCAACTTTCTCAAAC

CAGGGGCAAGCCGTGAATGGCAGCTCATCAGCCGCTGTACCACTAAGTC

CTGGAACAGAATCCCGCGACAAGGAACGTTTTGCTTTGTTATTGGACAT

CAACCATGAACTTCTGTACGAATCGATTCAΆΆTCCAGGAGACGCAAAAG

AAGTTGAAGAAAGAAAGCGCTGCGGCTGGAATTCCGGGAGACAACAAGC

CGTCAGAGGAGGAAGCGCAGCTACAGCATGATTATCTTCAATGTATGAG

GCGATTGCAGGCAAACTTATCTTATATGGCGGCACTTGCAGACCGAAAG

CCCGAGGTTAAAGTTCCACCTTGCCCAGCATATCTCAACGCACCACCCC

TAAATCTTTCTGCCAAACTCCGGCCTCCAGAAATTGAAGGCATAGAGAA

CAATATCGACCCAGTGGCAGACCGCGAAGAGCGAAACAATAGTATTAAG

GACCTCTACTCGAGATTACAAGCCGCCTTTCCCGGGTTCGATCCTAAGA

AAGAGCCCGTTTTCCGTGCGAACGCACAGGGTGGACAAΆAGCCTGGCAA

CATGATGGGAAGCCAGGCCAGTCCCACAGCTCAAAGGACACCAAAGATG

ACCAATATGGGGGCACCTCCAATGCCATAG unnamed ATGAAGCGAGAGATGTACTCTGGGCAGTCAGACGTTGCTGATACTGGAT 39 protein GGAGTGCTCCAAAGCCAGGTCATATGTCGCTAGAAAGGTCGAGGATGTT product; GCAGGCCGCGGCGGCCGCAGCCGCTGCTGGTGGTGGGAGTACTCCAAAC Kl uveromyces CATAATCAAAATTATAACAGACCTCCGAΆTATCAATACAAACAATAACA lactis; GCAGCAACAGCAACTCGTATGGTACTGGCAΆGCCGGGAAΆCGCACCTGG CR382125 ; ATTGGCAGGTACACCGGTGGGCATGGTTTCTGATCCTTCGCCTGTTCAG 49643087 GACΆCTATGGTGTTTAATGCAAGCGAGTACGACGATTTGCGAACCAAGA

AACTGCTCGATGCTTTCATCCATGACTTTCTAATAAAATCAAATTTGAA

CGAAACΆGCACAATCATTTGAΆCGAGΆΆGCGAAGCTTCTCGATGTTGAG

AAAAGGCTGGACCCCTCGCATGATGTCCCAGAGGGGTTTCTTTACGAAT

GGTGGCAGATTTTTTGGGACGTGTTTAACGCAΆGGACTCATAGΆGGCGG

ATCAGACGTCGCTAAGAAΆTATTTCGAΆCAGCAACTTCAACGGCAΆCGA

CAAGAACATACTTATAGAGGAGTTACCATGCATGTTGCTAGGGTTCAAC

AAACTGCTGAGCAGAAAGGATTTTACCAGCACGAAATGTTCGATCCAAT

GGAATTCGCGTCCATTGCTTCCATGGCTGCTAATAACCAATTTAATATG

TCCAATTCAGTAGCTCAGACGGCTCAGCCAAGTGTGCCTTCTTCGGCTT

CCTCGGCTAATTTCCCGGGGTATACACCTCAGTATAΆCTCCAΆCACTGC

TCCGATGGCTACTCATTCAGCAGCGTCGTCTCAACAGCAACAACAACAA

CAACAACAACAACAACAACAACAACAACAACAACAACAACAACAACAAC

AACCGCAACAGCCTATCAAACCTCAACCTCAGCGTCAACAAAATAATAC

TCACCCCTCTAGTGTACAGCAACΆTCAΆCAACAACAACATCATCTTCAA

ATGCAACATCATCTTCAAGGCTTCTATAATGGTGTACCAGGTGTTCCAA

ATGGAGGTTATTATACACCTTCTATGAATCCTTATAACAATACACAGCA

AGCTCAΆCAAGCTGCGTGTATGGGCTCTAATCCTGTTTCAAACTCTATA

CCGTTGGCAAGTAATΆGTGGACCAGCTGGTACTGGTACTGTTCCAACCA

ATTCTCATAACACTGCTAATAATGTAAGCAATAGTAGTGACAATGGTAA

CACTAATAACGGTAGTAATATCAATGTCAATGGAAATGAAGGCATCATA

AACAATGAACACATGACGCCCAATTCATCGTCATCCTATGCAATCAACA

TGGTAGCCCCCACTCAAATCCCAAGCTCAGGTCAGGGCCAGGCTCCTTA

TTCAAAACCATCTTCTTTATCCCAΆCAATTTGGATCCATTCCAACTTAC

ATCAATATGAACATTCCAAACTCTGCACCGGCGATGCCAAGTCAAAGAA

ATTCTCAAACCCAAATTCCTCACAACCAATCGGCTGCGTTAGTCCAAGG

CATGCTGTCCGCCCCTAGCTATTCTTCGCATCTGTCCAGTAACATTGGT

GTTAACAACATGCCAATGAATAGTATGAATACAATCCCTGGTTCAAACG

TAAATGGCATGCATCATAATACGAATCCTTCATTTGAAATGTCAAGTAT

GGATGGTCTATACAACTATCAGAAAGAGCTATTAATGCTAGAAAAGGΆA

AACAAAAAGGTTTTATCCATCGCAAAGGAAACATCCCTGTCTTCTGGAT

CTACGCCCCAGTTCTTGACTCTGTCTACATCTGGGAATGCTGGAAACAA

AAAGGGTTCAAACCCAATGCTCCCTCCTAATTCCTCACAGATTGCTACT

CCTCCTAACCAAAGTCCTTTAAATGTAGGAACTGCACCACCTGCTACCG

CTGCAGCTCCAAAGAAACGGAAGTATACCAAGAGGGTTAAGGATTTCAA

GAAATCTCAΆTCAGCACCAAACACGCCCAATACAACTGCATTGACTCCA

GGATCTGGAAATAGAAATAATATCCCATCTAATTTAAACCCCGTTTACG

AGCACTTATCTGCAAACAACTCGCCAAGAGATAAAACTCCGAAAGGTAA

CTTGGTTAATAATTCTCCGTTCACTTTGAACΆCAGΆGGCATCCACGGAA

AATGGAAAAGCCCCCGCTGGCAATAAACGAGCTCGTAAGAATAGCAGTA

CTAGGCAATTATCCGTTTCATCTACCACAACAACGAATAAACCAAAGAA

ΆGTGGCTGCAAAGAΆAACCCCAGTAGATATTACGACAACTCCACAGAAC

AACATCGAAGAAGAGGACTCCACCGGAGCTAGCAGCAAGGATCCTGGCA

GTAATAATAGCCTTGGATTGTTGCCGCATAATGCTTTGACCGATCCAAC

CCCACATACTGACTTCGATCCTATGAGTATAGATCCTGCTCTGAACGCC

TCTGCTGCATTTGATTATGCTGACAATGAGGATTCAΆTGTTGGGCACTT

TAGAAACTGCCTCTCTCGCGAAGAAAGGCGATACACAGGGCGATTCTAA

CGΆTGAATTTGCGAAAGACGAGAAGAΆCAGCGAGAAAΆTGΆAATTΆGAT

CAAAGCGGTTTCAATTTGGATTTCTTAGATCCGAATΆATAGCTATAATG

ATTTCAACTTCCTGAATTGGCAATGA unnamed ATGAAGCGAGAGATGTACTCTGGGCAGTCAGACGTTGCTGATACTGGAT 40 protein GGAGTGCTCCAAAGCCAGGTCATATGTCGCTAGAAAGGTCGAGGATGTT product; GCAGGCCGCGGCGGCCGCAGCCGCTGCTGGTGGTGGGAGTACTCCAAAC Kl uyveromyces CATAATCAAAATTATAACAGACCTCCGAATATCAATACAAACAATAACA lactis; GCAGCAACAGCAACTCGTATGGTACTGGCAKGCCGGGAAACGCACCTGG XM_454887 ; ATTGGCAGGTACACCGGTGGGCATGGTTTCTGATCCTTCGCCTGTTCAG 50309748 GACACTATGGTGTTTAATGCAAGCGAGTACGACGATTTGCGAACCAAGA

AACTGCTCGATGCTTTCATCCATGACTTTCTAATAAAΆTCAAATTTGAA

CGAAACAGCACAATCATTTGAACGAGAAGCGAAGCTTCTCGATGTTGAG

AAAAGGCTGGACCCCTCGCATGATGTCCCAGAGGGGTTTCTTTACGAAT

GGTGGCAGATTTTTTGGGACGTGTTTAACGCAAGGACTCATAGAGGCGG

ATCAGACGTCGCTAΆGAAATATTTCGAACAGCAACTTCAACGGCAACGA

CAAGAACATACTTATAGAGGAGTTACCΆTGCATGTTGCTAGGGTTCAAC

AAACTGCTGAGCAGAAAGGATTTTACCAGCACGAAATGTTCGATCCAAT

GGAATTCGCGTCCATTGCTTCCATGGCTGCTAATAACCAATTTAATATG

TCCAATTCAGTAGCTCAGACGGCTCAGCCAAGTGTGCCTTCTTCGGCTT

CCTCGGCTAATTTCCCGGGGTATACACCTCAGTATAACTCCAACACTGC

TCCGATGGCTACTCATTCAGCAGCGTCGTCTCAACAGCAACAACAACAA

CAACAACAACAACΆACAACAACAACAACAACAACAACAACAACAACAAC

AACCGCAACAGCCTATCAAACCTCAACCTCAGCGTCAACAAAATAATAC

TCACCCCTCTAGTGTACAGCAACATCAACAACAACAACATCATCTTCAA

ATGCAACATCATCTTCAAGGCTTCTATAATGGTGTACCAGGTGTTCCAA

ATGGAGGTTATTATACΆCCTTCTATGAATCCTTATAACAATACACAGCA

AGCTCAACAAGCTGCGTGTATGGGCTCTAATCCTGTTTCAAACTCTATA

CCGTTGGCAAGTAATAGTGGACCAGCTGGTACTGGTACTGTTCCAACCA

ATTCTCATAACACTGCTAATAATGTAAGCAATAGTAGTGACAATGGTAA

CACTAATAACGGTAGTAATATCAATGTCAATGGAAATGAAGGCATCATA

AACAATGAACACATGACGCCCAATTCATCGTCATCCTATGCAATCAACA

TGGTAGCCCCCACTCAAATCCCAAGCTCAGGTCAGGGCCAGGCTCCTTA

TTCAAAACCATCTTCTTTATCCCAACAATTTGGATCCATTCCAACTTAC

ATCAATATGAACATTCCAAACTCTGCACCGGCGATGCCAAGTCAAAGAA

ATTCTCAAACCCAAATTCCTCACAACCAATCGGCTGCGTTAGTCCAAGG

CATGCTGTCCGCCCCTAGCTATTCTTCGCATCTGTCCAGTAΆCATTGGT

GTTAACAACATGCCAATGAATAGTATGAATACAATCCCTGGTTCAAACG

TAAATGGCATGCATCATAATACGAATCCTTCATTTGAAATGTCAAGTAT

GGATGGTCTATACAACTATCAGAAAGAGCTATTAΆTGCTAGAΆAAGGAΆ

AACAAAAAGGTTTTATCCATCGCAAAGGAAACATCCCTGTCTTCTGGAT

CTACGCCCCAGTTCTTGACTCTGTCTACATCTGGGAATGCTGGAAACAA

AAAGGGTTCAAACCCAATGCTCCCTCCTAATTCCTCACAGATTGCTACT

CCTCCTAACCAAAGTCCTTTAAATGTAGGAACTGCACCACCTGCTACCG

CTGCAGCTCCAAAGAAACGGAAGTATACCAAGAGGGTTAAGGATTTCAA

GAAATCTCAATCAGCACCAAACACGCCCAATACAACTGCATTGACTCCA

GGATCTGGAAATAGAAATAATATCCCATCTAATTTAAACCCCGTTTACG

AGCACTTATCTGCAAACAACTCGCCAAGAGATAAAACTCCGAAΆGGTAA

CTTGGTTAATAATTCTCCGTTCACTTTGAACACAGAGGCATCCACGGAA

AATGGAAAAGCCCCCGCTGGCAATAAACGAGCTCGTAAGAATAGCAGTA

CTAGGCAATTATCCGTTTCATCTACCACAACAACGAATAAACCAAAGAA

AGTGGCTGCAAAGAAAACCCCAGTAGATATTACGACAACTCCACAGAAC

AACATCGAAGAAGAGGACTCCACCGGAGCTAGCAGCAAGGATCCTGGCA

GTAATAATAGCCTTGGATTGTTGCCGCATAATGCTTTGACCGATCCAAC

CCCACATACTGACTTCGATCCTATGAGTATAGATCCTGCTCTGAACGCC

TCTGCTGCATTTGATTΆTGCTGACAATGAGGATTCAATGTTGGGCACTT

TAGAAACTGCCTCTCTCGCGAAGAAAGGCGATACACAGGGCGATTCTAA

CGATGAATTTGCGAAAGACGAGAAGAACΆGCGAGAAAATGAAATTAGAT

CAAAGCGGTTTCAATTTGGATTTCTTAGATCCGAATAATAGCTATAATG

ATTTCAACTTCCTGAATTGGCAATGA

Frequency ATGTCGGACCTCAAAAGTAAACGCCGCAACGCGCCATCGCTGGCGCAGC 41 clock protein; ACACATACCCCCGGAGGGTGTCCCCCGAAAATTCGGTCACGCTCCGACA Leptosphaeria TCACCGGCTAGCACGCGATGCCAGCCTGCAAGCAAACTCCTCGAGATCT austra.lien.sis; CAGGCGGCGACGTCTTCACCGCGACGAAATTCTTCCGACGAGAGCCATG

U25851; ACACCGGCCAAAGCGACGCGAATAAGTGGTTCGACCAGTCGAACCTTAA

852503 CCCTACCGCCAACTATGACAGCAATGCCATGGACGTTGATCCTCCGTTT

TATCΆGAGAGAGTCAGAGTCGTCCAATGAAGGAGGCAAAΆTTCCCTACC

ATGGCGGATCCGTACCCATGCTCAAGCCCACCGTCACGCACAGCAGCAG

TGCCGATGACTATCGCTCCGTCATCGACGACTTGACGGTGGAGATCCAG

AGGCTGAAGGAAGAGTTGAAGCGATACAAGCAATTCGGATCCGACGTGA

TGAAGAACGAGAAGCTTTTCGAAATCAAGGTGCATGGGTTGCCGAAGAG

GAAAAAGAGGGAATTAGAGGCAACGCTGCGGGACTTCGCCGCGAGTCTG

GCCGGAΆCCTCGAGCACTGACATGGCGTCGTCTCACAAGAΆGAAGTCGT

CCCGGCACATGAATCGGATGCAGTCGTCTGCCTCCGGATCCATGTCAAA

GCACGCCTCGTCTTCGGCAGGGTCGCATTCGCGACCGGTCGATTCTGCC

TATGCTTCCATGTCGACAGGGCCGAACTCATCTGGAACATCGCTGAACC

GGCCATCAATGAGCGCGCGAGCGAGGACATCTGAGCAAAΆAGTTGAAAA

CTACCTCCGAGACATTCCCGAGGGGCTCTACCCGAGACACATGATCATG

ACTGAGAAGGAGCGAAAGAAGTTGATTGTTCGCCGCCTGGAGCAAATAT

TCACGGGAAAGATGGTCCGCGGAGCGAACACGTCAAACTCATACCAAGT

CAACTCGGGCCTAACGCCAGTCACGCATGACGGTCAGAGTGGGAAAGCA

GCGGGGTTGCACCAGCCCCCGAGTCTCAAGGCTCCGCCGATAAATGTGG

AAAACATCGΆGCCGGCAΆGGGAGGCAΆGGATCTTGCCGGCTGATAACΆT

GAAGAAGAGTCGGTCTCGAGACAATGAGTCCACGTCAAACTCGAATCAG

GACCAAACCGAGTCCGGAGGCAAAACTGCCAACAGCGGCTCAGGATCCA

ACACATCTCCACCTATTGCTCCGCCTCCCGAGCAGCGGCCCACGCGCCC

CTTGGATCTTGATCCTCATCGCACACAGGTTCCGTCCGAGAACATGGAA

TATCTCCGGCATCTTGGCCTGGTGCCTCCGGAACTGCTGCCCGACTCCA

ATGACCTAGAAGGAGACGTTGCACCAGACGCCGACGGGTGGATACATCT

CAACCTTCTTTGCAACCTCGCTCAGCTGCACATCCTTAACGTGACACCC

GACTTCATACGATCTGCTGTCAACGAGAAGAGTACCAAGTTTCAACTGT

CACGTGACGGCCGCAAGGTCCGTTGGCGCGGTGGCCTCGACGGGACGCG

ATTCAGCAGCGACAGCTCGGGCGACAACTCGCAAAGTCCTGTCGGCGAC

GAGACTGACAGCTCAAGCAAGAATGGCCAGCGCAAGAAGCGTAAGGTTG

TGACAGCCGACGGCCAGACAACCTCCGCTCCATCAAGTAAAGAGGCATC

GAAGTATGACCGCCAAATATCGCAGTCTTCGGACAGTTTCCACTATAAA

CCGCTGTTCGCTCACCACCCCTCATCGCACGAAACTTCTCTTGATACAG

GCTCCTCATATGGGCCGCCAGAGGAAAGTGCACAGGGTGACTCACGCTG

GGGGTTGAGTGGATCGGGGGGCACGTCGCAGCGTAAGAAACGCCGTGTA

GACGGGGCCATCGTATATTACAGCGGCGCGCCATTCTGCACCGACTTGT

CCGGCGATCCGGGTGACGCAGGCGTTGACAGCCAGACTGGTGGCATCTC

TCCGGCCACGTACATGCAGAATGCCGGGCAGGCCCAAGCCAAGGCAGAG

GCGAGGGCCGAAAAAGGGAAGGTGCCACCAΆAAGCGGTCCGAATGGTCC

CTATCAGAAGTCAGTCAGGATCCTTTCTACCTCACCGACCGCTCACCGC

CTTCTCTCCGTCTACCGAGGATGTCCCCATGTCAGATGTCGACGAAGCA

ATAGCGCTGGAGGATGACATAGAGATGGAGTTTCCCTGGTCAGACAGTC

AGCAATATCTCGAAGTTCGACCTCTCGAGCCTAGCGGTCTCGGCGGCGT

ACTTCCTGATGACAATTTCATGGTGGTTGTCACGACCAAGCGACCACAC

GGAATGGAGCCCGGAGAGAAGACCCCAGCTCTCGGGCGCACAAAGTCTG

ATGAGACAACGCGAACAACTGATTCCATCGTTAΆTCTTCTCGCCTCGAT

GAGTACGTCGGGTAATGAGAACATGCCCGCGGGGCGTCCAGTTCTACAT

AAGACTGGGAACATTGAGATCGAATACCTCTCAGGAAGAATCAAGCGTC

TGAACCCAGTTCCTCTTCCGCCTCCGGCCATTTTCTTCCCTCCGTTTAG

CTCGACATCGTCGTACAACTCGGAGTTAGATTTGGGCTCGGATGCTGAT

GACGΆTGΆGTCTTCGGAAGAGTTCATGAGTCGGCGCGCCAΆCCCCCACC

AGTCCGACAACGAATATCCCGACGATGTTGACATAACAAGCGGTGATGA

AGTCGGCGAGGAGCCAGACGATGAGCTGGCTCCCACAGATGATGATGAA

GAAATGGAGTCCGCCGGTGACGAAGGAGGCGCATCCAGGGGTΆGGGCCG

CCGGGCCACGAAGTGCGAGACCGAGCCTACCCAGCGGCAAGTCAGCAGG GCACAGAGCGGTGAGGCGGACTGGAAGTCTTGCAGCGACAGCAGGAGGA GAΆGAAΆGTGGTTACAGTAGTAGCGCGGAGGAGTCGTGA

Hypothetical ATGTACGATGCCGCTAGGGGCGTATTGAAAAGTGGCCAACCCATCAATG 42 protein TTGAACAAGATCGCGAGAATGGGCTCGGCGGCGACTCTATGGATACCGA

MG04708.4; CTCCAAAGACGATGTCAATAGCAAGAAGCCCGAAGACCTCCCCGCGCCC

Magnaporthe ATACTTGGTTCCGCGACACCCGACATCAGCTTCTTGTACGAGTGGTTCT grisea; CGATGTTTTGGGACTTGCTGAACGCCTCCAAGGGCAΆATACGCACCGGC

AACU01001152; CCAGGTCAGCCAATACATTACACATACGCAGAACCATACACGGATGAGA

38104369 CAGCAGACTCAACAΆGAGATGTTGCGGGGCΆTGCGΆCCCGACATGGCTG

CTCAGCAGCAGCAGTTTCTGATGATGAACAGGCCAAATGGAAACATGAA

CATGATGAACAAGAACCAGAGCTTACATCGTGGTGCCATCGCCAACACC

CAGAACCAAATGCAGATGCTCGCTCAACAAAAGCAΆGGCCAGATGCAAC

GCGATCCTTCGGACATGGACGGTAACCGCCAAAGACCCAGCTCCCCTAG

TTCAGCTGACAATGCTCCATCACCCTCGAAGCGGGTGCGTCTCGACGGC

GGCCCTGGGTTCAACCCGGGCCAACCCGGAATGATGCCGAATGGTCGTC

CTGGCGCACCAGGAΆTGCCCAATCAACAGACGTATGCGCAGAACCTACA

GCAGCACCACGGCAACCAAATGCCTAACAAGCCCATGCCTGGCCCCAAC

GCCCCCCAGGGTCAAGGCTCGCCGATGGTTGCCTCTGGCCCCGACGGCA

CACAGCTCAATGCATTCTACAATGCTCAAGAACCGATGGGTGCCGCACC

CAACGGCGGAATGCGTCCCGGCGTCCCAGCCACTCAGAACGGAAGCAAC

CATGCTCTTCAAGACTACCAGATGCAGCTCATGTTGCTAGAGCAACAGA

ACAAGAAGCGACTGATGATGGCCCGGCAAGAACAGGACGGCΆTTCAAGG

ACAAGGTATGGCTCGGGCCGATGGTCCTGGCGGTCCCGGTCCTGCCGGT

GGCCCCGGCGGTCCCGCAGGCGCACCGAACGGACCCCAGTTCCAAGGGG

CTTCTCCCCAGGGCGCGAGGCCCGGTGCTTCTCCGAACCCGAGCGAGCA

GATGAAGCGCGCCGCTGGGCAGATGAACAATGGTAGCATGGGATCACCT

CTTCCGGAAGGCGCTCAAAACCGCGAGTCCCCGAACAACCCGATGAACT

TCATGGGTACGAATATGGATCCCAACGGCGCACCGCACTTCTTCAAAGG

TATTAACAACGGCATGGATGCAAACATGGCAGCCGCGCAGATGAATGGA

GGCATGAΆCCGGCCCCCTAGCTCGCACCCGGGCCAΆCAGCCCTTCAGCC

AGATGAATCCTCAGCAGCAGGCCATGATGCGTCAACAGCAGATGCAACA

GCAGCAGCAGGGTGGTCCCAATGGCCAGCCCATGCCCGGGCAATGGCAA

GGTGGACCTAACGGTCAGATGCCCGGTGGTCCTCAGGGCGGCCCGCAAC

AGGGACCTGTCCACGGAACGCCCCAGCAAAGGGCGATGCCCCCGCCTTC

GGCACCCACGGCCGCAGCAAACAGCAACGCGAATCAGAGGAACACTACA

GCATCCCCGCAGGTTTCCAACGCCGCGCCGCCTACGCCATCACAAGCTA

ACAAGGCAGCCCCCAAGAAGAAGGATACCAAAGCTAAAGACAAGCGGGC

CGCCACGCAGAAGAAGTCCAATGCAAACCTGAATGCCGCCGGGGGTGCT

ACACCCGCGGCCGACGGAGGAAACGACGGCGAGGCTCCTACCCCGGCAA

CTCCCATGACGCCGATGGCTGCCTCACAGCAAAACTTCAACAAGCCTGG

GCCTGCCGCAGGGGGTGCTCCACCGCAGCAGATGCCTAATGGTCAACCT

CCCGCCGCTGCCCCTACAGCGGCACCAGTCGCTCCTCAGCAACACAΆCG

ACCCCAACCAGTTTAACATGGAGGGAGGCGGAATGGACTTCAACTTGGA

CTTCGCTAACCCATTGGCCTCGGGCGACGTACTTAACGATTTCGACTTT

GACTCTTTCCTGCACGATAACGTGGAAGACACCGGATTCGGCTTCGACG

GCCCCGGCCTCAΆCTTCGAGGGCACCAACGAAATTGGCGCCGACTAG

NcSOMl; ATGAACATGAACAACATGGGTAACATGGCGCAGATGAACGCCATGGGCG 43 Neurospora GTCCCGTCGGCGGCGCCCCTATGCCAATGATGAATAATGGCGCAATGCC crassa; CGTCCGTCCTCAGCAGCCCCCACAACCTCAACCGCAACAGCAACAACAA AF265233; CAGCAGCAGCAGCAGCAGCAΆATGCATTTTGGGGCTGGAGCTATCGATG 8453193 GCGGCCGTTCGTTGCTCGAGACCTACATCTACGACTATTTCATCCGCCA AGGCATGTACGACGTTGCCCGCACAATGCTACAAΆATAACCCTCAGATC AAGACGGACAAATCTGCGAGCCCTGGTCAAAACTTGAATGGCCTGGGTG ACGATCCCATGGATACCGACTCAAAGGACAΆCCTGGACCAAAAGCGTCC CGACGACCTACCCCCAGCTGCGATTCCGAATTCCTCGACAAGCAATAAC CCCTTTCTGCTCGACTGGTTCTCACTGTTCTGGGATATGTTCAΆCAGCC AAAAGAGCAAGGGCCCTGCTCTTGTGAACCAATATGTGCAACACAACCA

GAACCAGTCCCGCATGCGTCAGGAACAGATGCTGCGGCAAATGCGTCCT

GACTACGCCCACGTGCAATATCAGCAGCAAATGATGAGGAACATGAATG

GTATGGGCGGCATGATGAΆGCCCGGΆAACCAGCTGCCACGGGCAGCCAT

GGCGAACAGCCAAAATCCCCAAGCCATGCACATGCTTCAGGCACAGAAA

GCTGCTTCAATGCAGCGAGATCCCTCGGATATGGAAGGAAACCGAGTGA

GGGCGGCGTCGCCAGGATCGGCAGACAACGCGCCATCCCCATCCAAGCG

GCCACGTCTCGAGGGGGCCCCCTTCAACCCCAΆCGCGGGTGTCATGGTG

CCCAATGGCAGACAGATGCAAGGCATGCCAGGCCAGCAGCAGGTAGGAG

GTGGCCCCAΆTTCAGCACAAGCATTTTTCATCAACCAAATCCGCCCAAA

CTCATTAACTCTTGACCAACTCCAGGTCTTAATCAATGCCAATCCCAAT

CAGCTCAAAGCGTACGCCGCTAACCTCCAGCAGCACCACGGTAAACAGA

TGCCCACCAATCCGATGGCGAATGCTGGCGGTCCGCAAAACCAGGGCTC

TCCTATGCTGCCGCAGGGACCCGATGGCCAGAACATCAACCAGTTTTAC

AACCAGGAAATGGGCGCCGGAAACATGCGAGCTGGGCCTGGTAACGGCC

AGAACGGGTCAAGTAACCATGCCCTTCAGGACTACCAGATGCAGCTGAT

GCTCCTCGAGCAACAAAACAAGAAGCGTCTCATGATGGCTCGACAGGAG

CAGGATGGGATGCCACGACCTGAAGGCCCCAACGGTCCAGGCGGACCTG

GCGGCCCGGGAGGACCTCAGGGACCGAATCCTCAAGGCTTCCAAGGCAA

TTCGCCACCTGGGCAGCGCAATGGAGCATCACCTAACCCTTCGGAGCAG

ATGAAGCGTGCCAACCAGCAATTGAACAACCCCCAGAACATAGGTTCCC

CTCTTCCGGATAGCGCCCAGAACCGCAGTTCACCGAATCCAACGATCTT

TATGGGCGGCAACATGGATCCCAACGGAGGACAGCCCCATTACGGCATG

AACATGAACATGGGCAATCAGATGGGAGGCGGTATGCGTCCACCGAACG

CACACCCAGGACAGCCCTTCAATGGCCAAATGAACCCACAGATGATGGC

TGCCCAACAGCAGCGTCAAGCACAAΆTGCAACAGCAGGCTCAGCAGCAA

GCACAACAACAACAGCAACAAGCCCAACAAGCGCAGCAGCAACAAGCGG

CTCAACAGCAGCAAAACCAAGGGGGCCCTAATATGCAATGGCAGCAGCC

TGGACCCAATGGCCAGATGGTTGGTCAGCCTCCTCAAGCTCAGCAGGCT

CAGGGTCCAGCGCAGCAGAGAGCCATGCCGCCACCTTCTGCTCCCCCAA

CGGCAGCGGCGATGACCAACGCTGCCAACTCGAGGAACGCGACGTCATC

TCCTCAAGTCACCAACGCTGCTCCTCCAACCCCCAACCAGGGCAACAAG

CCGGCACCCAAGAAGAAGGAGACCAAGAATGCTAAGAACAAGAAGAAAT

CCAATCAGAACCTCAACGCAGGTGTTACACCTGCTGCAGATGCCGΆCCA

GCCGCAAGAACCTCCGGCGCCGGCCACTCCAATCACCCCAGTCAACCCA

GCTAGTTTCAACAAGAACCAΆGTΆGGCAACCAGGTTGTΆCAGAATGGAC

AGCCGGCTGCCCCGGTCCCGCCGCCCTCCGTGCCTCAGGTCGCCGCCCC

GCCACACCCGGACCCGACCCAGAACAACAATTTCGCCGAACCAATGATG

AACTTCGATGTTGAGTTTGCCAACCCACTCΆCGTCAAΆCGATGTTCTGA

ACGACTTTGATTTCGACTCCTTCTTGCACGATAATGACAATGGCGGAGA

GACTTTCGACTTCAATGCCGGCGTGTTTCTGGATGGCΆACGAGATCGGA

ACGACGGAGTAG

Hypothetical ATGAACATGAACAACATGGGTAACATGGCGCAGATGAACGCCATGGGCG 44 protein; GTCCCGTCGGCGGCGCCCCTATGCCAΆTGATGAATAATGGCGCAATGCC

Neurospora CGTCCGTCCTCAGCAGCCCCCACAACCTCAACCGCAACAGCAACAACAA crassa; CAGCAGCAGCAGCAGCAGCAAATGCATTTTGGGGCTGGAGCTATCGATG

XM_325645; GCGGCCGTTCGTTGCTCGAGACCTACATCTACGACTATTTCATCCGCCA

32410330 AGGCATGTACGACGTTGCCCGCACAΆTGCTACAAAATAACCCTCAGATC AAGACGGACAAATCTGCGAGCCCTGGTCAAAACTTGAATGGCCTGGGTG ACGATCCCATGGATACCGACTCAAAGGACAACCTGGACCAAAAGCGTCC CGACGACCTACCCCCAGCTGCGATTCCGAATTCCTCGACAAGCAATAAC CCCTTTCTGCTCGACTGGTTCTCACTGTTCTGGGATATGTTCAACAGCC AAAAGAGCAAGGGCCCTGCTCTTGTGAACCAATATGTGCAACACAACCA GAACCAGTCCCGCATGCGTCAGGAACAGATGCTGCGGCAAATGCGTCCT GACTACGCCCACGTGCAATATCAGCAGCAAATGATGAGGAACATGAATG GTATGGGCGGCATGΆTGAAGCCCGGAAACCAGCTGCCACGGGCAGCCAT GGCGAACAGCCAAAATCCCCAAGCCATGCACATGCTTCAGGCACAGAAA

GCTGCTTCAATGCAGCGAGATCCCTCGGA_TATGGAAGGAAACCGAGTGA

GGGCGGCGTCGCCAGGATCGGCAGACAACGCGCCATCCCCATCCAAGCG

GCCACGTCTCGAGGGGGCCCCCTTCAACCCCAΆCGCGGGTGTCATGGTG

CCCAATGGCAGACAGATGCAAGGCATGCCAGGCCAGCAGCAGGTAGGAG

GTGGCCCCAATTCAGCACAAGCATTTTTCATCAACCAAATCCGCCCAAA

CTCATTAACTCTTGACCAACTCCAGGTCTTAATCAATGCCAATCCCAAT

CAGCTCAAAGCGTACGCCGCTAACCTCCAGCAGCΆCCACGGTAAACAGA

TGCCCACCAATCCGATGGCGAATGCTGGCGGTCCGCAAAACCAGGGCTC

TCCTATGCTGCCGCAGGGACCCGATGGCCAGAACATCAACCAGTTTTAC

AACCAGGAAATGGGCGCCGGAAACATGCGAGCTGGGCCTGGTAACGGCC

AGAACGGGTCAAGTAACCATGCCCTTCAGGACTACCAGATGCAGCTGAT

GCTCCTCGAGCAACAAAACAAGAAGCGTCTCATGATGGCTCGACAGGAG

CAGGATGGGATGCCACGACCTGAAGGCCCCAACGGTCCAGGCGGACCTG

GCGGCCCGGGAGGACCTCAGGGACCGAATCCTCAAGGCTTCCAAGGCAA

TTCGCCACCTGGGCAGCGCAATGGAGCATCACCTAACCCTTCGGAGCAG

ATGAAGCGTGCCAACCAGCAATTGAACAACCCCCAGAACATAGGTTCCC

CTCTTCCGGATAGCGCCCAGAACCGCAGTTCACCGAATCCAACGATCTT

TATGGGCGGCAACATGGATCCCAACGGAGGACAGCCCCATTACGGCATG

AACATGAACATGGGCAATCAGATGGGAGGCGGTATGCGTCCACCGAΆCG

CACACCCAGGACAGCCCTTCAATGGCCAAATGAACCCACAGATGATGGC

TGCCCAACAGCAGCGTCAAGCACAAΆTGCAACAGCAGGCTCAGCAGCAA

GCACAACAACAACAGCAACAAGCCCAACAAGCGCAGCAGCAACAAGCGG

CTCAACAGCAGCAAAΆCCAAGGGGGCCCTAATATGCAΆTGGCAGCAGCC

TGGACCCAATGGCCAGATGGTTGGTCAGCCTCCTCAAGCTCAGCAGGCT

CAGGGTCCAGCGCAGCAGAGAGCCATGCCGCCACCTTCTGCTCCCCCAA

CGGCAGCGGCGATGACCΆACGCTGCCAΆCTCGAGGAΆCGCGACGTCATC

TCCTCAAGTCACCAACGCTGCTCCTCCAACCCCCAACCAGGGCAACAAG

CCGGCACCCAAGAAGAAGGAGACCAAGAATGCTAAGAACAAGGCTGCTA

CGCAGAAGAAATCCAATCAGAACCTCAACGCAGGTGTTACACCTGCTGC

AGATGCCGACCAGCCGCAAGAACCTCCGGCGCCGGCCACTCCAATCACC

CCAGTCAACCCAGCTAGTTTCAACAAGAACCAAGTAGGCAACCAGGTTG

TACAGAATGGACAGCCGGCTGCCCCGGTCCCGCCGCCCTCCGTGCCTCA

GGTCGCCGCCCCGCCACACCCGGACCCGACCCAGAACAACAATTTCGCC

GAACCAATGATGGTAAGTCCGGAACCTTTGTTCATTGCCCAGCGGAGGG

TGCTAACCAGCAAGCTGCAGAACTTCGATGTTGAGTTTGCCAACCCACT

CACGTCAAACGATGTTCTGAACGΆCTTTGATTTCGACTCCTTCTTGCAC

GATAATGACAATGGCGGAGAGACTTTCGACTTCAATGCCGGCGTGTTTC

TGGATGGCAACGAGATCGGAACGACGGAGTAG

Hypothetical ATGTCCGGCAATCAACAAGGCCAGTGGCCACCATTCGTCGGCTACCAAA 45 protein; TACCCAACATGTCTGGCAATCAACAAGGCGACTTACCGCAATTCGAAGT

Neurospora. CAATCAAGGGCCCΆTGATATCTGGTGCTCAGCCAGGCGAAGΆACCCAAG crassa; TTTGGCGAAGATGAGACGCCTACCGGTAACATCCTGTATGAACACTCGC

XM_327362; AAGCGGATTTACAGCAGTTCGACGTCAACCAGATGCCTACCGGTAGCAT

32413766 GCATAGAAGTCAGCAAAGCGAGTTACCGCAATTCGACCCTAACGAATTG CCTGGCCTGTTTGAAAATCAGCATGGAGAGTTACAGCACTTCGACGTCA ACCAAGCGCCCATGTTGTTTGGCGATCAACAAGGCGTGCTACTAGAGCA TTTTGACGACGTCAACCAGΆTGCCTACCGGTAGCATGTATGAAAGTCAG CAAGGCGAGTTACCGCAATTCGACGCCAACGAAATGCCTGGCATTTATG AAAATCTACAGCAGTTCAACGCCAACCAGATGCCCATGTTGTTTGACGA TCAACAAGGCGTGCTACTAGAGCATTTTGACGCCAΆCCAGATGCCTTCC GGTAGCATGTATGGAAGTCAGCAAGGCGAGTCATCTCTTTCCCCTTCCA ACCCGGTGCCCATGATGTTTGACAATCAACAΆGGCGAGTCGTCGCTGTC CCCTGCCAACCAGGTGCCCΆCGATGTCTAGCAATCAGCAAGGCGAGTTA CAGCAGTTCAACGCCACTCAAATGCCCACGATGTCTAGCAATCAGCAAG GCGAGTTACAGCAGTTCAACGCCACTCAAATGCCCACAATGTCTAGCAA

TCACCTTCCGCTTTAGCTTCTAAACAGCCCACAAAGGTAAGGAAAAATA

CAAAAAAGGCATCCACCTCAGCTTTTCCAGTAGAGTCTACGAATAAACT

CGGTGGCAACAGCGTGGTGACAGGTAAAAAGCGCAGTCCCCCTAACACT

AGAGTGTCGAGGAGGAAATCCACTCCTTCTGTTATTCTGAATGCTGATG

CCACTAAGGATGAGAATAATATGTTAΆGAACATTCTCGAATACTATTGC

TCCGAATATTCATTCCGCTCCGCCCACTAAAACTGCGAATTCTCTCCCT

TTTCCAGGTATAAATTTGGGAAGTTTCAACAAGCCGGCTGTATCCAGTC

CATTATCTTCAGTGACAGAGAGTTGCTTCGATCCAGAAAGTGGCAAGAT

TGCCGGAAΆGAATGGACCCAAGCGAGCAGTAAACTCAAAAGTTTCGGCA

TCATCCCCATTAAGCATAGCAACACCTCGGTCTGGTGACGCTCAGAAGC

AAAGAAGTTCTAΆGGTACCAGGAAACGTGGTTATAAAGCCGCCACATGG

GTTTTCAACCACCAATTTGAATATTACTTTAAAGAACTCTAAAATAATC

ACTTCACAGAATAATACAGTATCCCΆΆGAATTGCCGAΆTGGGGGAAACA

TACTGGAGGCGCAAGTAGGCAATGATTCAAGAAGTAGTAAAGGCAATCG

TAACACATTATCTACTCCAGAGGAAAAAΆAGCCGAGTAGTAATAATCAA

GGATATGATTTTGACGCCCTCAAAAATTCAAGTTCTTTGTTGTTTCCTA

ATCAAGCTTATGCTTCTAACAATAGAACACCAAACGAGAATTCAAATGT

TGCTGATGAAACCTCTGCATCTACAAATAGTGGCGATAATGATAACACA

TTAATTCAGCCCTCATCCAATGTGGGTACAACTTTGGGTCCTCAGCAAA

CCAGTACTAATGAAAATCAGAATGTACACTCTCAGAACTTGAAGTTTGG

GAATATTGGTATGGTTGAAGACCAAGGACCGGATTACGATCTCAATTTA

CTGGATACAAATGAAAATGATTTCAATTTTATTAATTGGGAAGGCTGA

MSSIl; ATGGATAACACGACCAATATTAATACAAATGAGCGCTCTAGTAACACGG 47

Saccharomyces ATTTTAGCTCAGCTCCCAATATCAAAGGTTTGAATAGCCATACTCAGTT cerevisiae; GCAGTTTGATGCGGATTCTCGAGTTTTCGTTTCGGATGTAATGGCTAAG

NC_001145.2; AACTCTAAGCAATTATTGTACGCCCATATTTATAACTATTTAATCAAAA

44829554 ACAATTACTGGAACTCTGCCGCAAAATTTTTAAGCGAAGCTGACCTTCC

TTTATCTAGAATAAACGGATCTGCTTCGGGTGGGAAAACTAGCTTGAAC

GCCAGCCTGAAGCAGGGATTAATGGATATTGCATCTAAGGGTGACATTG

TTAGTGAAGATGGGCTATTACCTTCGAAAATGCTGATGGACGCTAATGA

CACGTTTTTACTGGAATGGTGGGAAATTTTTCAATCATTGTTCAΆTGGA

GACCTAGAΆTCTGGGTACCAACAGGATCATAATCCTTTAAGΆGAGAGAA

TAATACCAATTTTGCCAGCTAATTCTAAATCTAΆTATGCCTTCCCATTT

CTCTAATCTCCCACCAAATGTGATTCCACCAACTCAAAATAGTTTTCCA

GTTTCAGAGGAGAGTTTTAGGCCCAATGGTGACGGAAGTAACTTTAATT

TAAACGATCCAACCAATCGAAACGTCTCCGAAAGATTTCTATCGAGAAC

TTCCGGTGTCTACGACAAACAGAATΆGCGCTAΆTTTTGCACCTGATACT

GCTATAAACAGTGATATTGCTGGGCAGCAGTACGCAACTATAAATCTAC

ATAAACACTTCAATGATTTGCAATCACCAGCACAGCCCCAGCAATCΆTC

TCAACAGCAGATCCAGCAGCCTCAGCATCAACCCCAGCATCAACCGCAA

CAGCAACAGCAACAGCAACAACAACAACAACAACAGCAACAGCAACAGC

AACAGCAACAGCAGCAACAGCAACAGCAACAGCAACAACATCAACAGCA

GCAACAGACACCGTATCCTATTGTCAACCCACAAATGGTCCCTCATATT

CCATCGGAAAATTCTCATTCAACCGGACTTATGCCTTCAGTGCCTCCTA

CAΆATCAACAATTTAATGCACAAACCCAATCTTCAΆTGTTTTCAGACCA

GCAGCGCTTCTTTCAATATCAATTACACCACCAAAATCAAGGACAGGCG

CCATCTTTTCAGCAAAGCCAATCTGGCAGGTTTGATGACATGAACGCTA

TGAAAATGTTTTTTCAGCAGCAAGCACTACAGCAAAATTCACTACAGCA

AAATCTTGGAAATCAAAATTATCAATCTAATACACGTAACAATACTGCG

GAΆGAAACTACGCCCACAAATGACΆATAACGCAAATGGCAΆTΆGTTTAT

TGCAAGAACACATACGAGCCCGCTTCAΆTAAGΆTGAAAACAATTCCTCA

ACAAΆTGAAAAATCAAΆGCACTGTCGCAAATCCGGTTGTTAGTGΆTATA

ΆCATCTCAACAGCAGTACATGCATATGATGΆTGCAAAGAATGGCGGCTA

ACCAGCAATTACAAAATAGTGCCTTTCCTCCAGACACTAATCGTATAGC

GCCAGCTAACAΆCACTATGCCATTACAΆCCΆGGAAATΆTGGGGTCTCCT

GTCATTGAAAATCCAGGTATGAGGCAGACTAΆTCCATCCGGACAAAACC CTATGATCAATATGCAGCCCTTATATCAAAATGTTTCTTCCGCAATGCA TGCGTTCGCTCCGCAACAACAATTTCATCTACCACAACATTATAAAACC AATACTTCAGTΆCCACAAAATGATTCTACCTCCGTCTTTCCTTTGCCTA ACAATAACAATAACAATAACAACAACAACAATAATAATAATAΆTAATAA TAGTAATAATAGTAATAΆTAATAATAATAATAATAATAATAATAATAAT AGTAΆTAATACACCCACAGTATCACAACCATCATCAAAATGTACTTCTA GCTCCAGCACAΆCTCCTAATATAACTACAACAATTCAACCCAAGCGGAA ACAGAGAGTGGGTAAAACAAAGACCAAGGAATCAAGAAAAGTTGCTGCA GCTCAGAAAGTTATGAAΆTCTAAGAAACTGGAACAAAATGGTGATTCAG CTGCTACAAACTTCATCAATGTCACTCCAAAGGACAGTGGCGGTAAGGG TACCGTAAAAGTTCΆAAACAGTAΆCTCGCAGCΆACΆACTAAATGGCTCT TTTTCTATGGATACAGAAACATTCGACATATTTAACATTGGTGΆCTTTT CTCCTGATCTAATGGATAGCTAA

SpSPCC70.01; ATGGCTGATTTCATGGACATAGAGCCATCCTCTCATTCTGCAAAAGCTT 48

Schizo- CTCAATACGAATCCTCGGCTCCTGCGTCTTCTTCACTGGGTAATTCGCA saccharomyces TCCAAACGAGTCTCTGGATTATTATATATACGACTATTTTGTTAAGCAC pombe; AACTTTGAGGAAGCCGCACAGGCTTTTTTACGAGAGTCAAAAATTCAAA

NC_003421; TTCCAAAATCTTCTTCATCTACTGCCTTTTCACCTTCCAACAATAACGC

19075172 ACCTTCACCTTTCCCCCCAAAGAATTCATCTTTAGCCTCTCCTAGCAAA

ATTTCTGAATCGΆTTTCTGGTGATCGACTTTACAACCACΆTGTCATCAG

CTCCGTCTCCCAACAAAAAGGAAGAAACCAATGTCGTACATGCTAACGA

GGACATTTCΆTTΆGΆTAAACGCCAGTCATTTGGATCATCATCCCTTCCC

CCTTCTGAAGTTTCTATAAATGTTCCCGAAGGTTTCTTGGTGGAGTGGT

TTAATATTTTTTGGGATGTATTTAGTGCGCGAGTAAGTCGTGTAAATAG

CACGCCTATTCAATTATATGATCCTTCTACTCAAAGACAΆATGGCCCGT

CCCATGTCTAACCTCCAAGCATCTCAACCTGTTCCTTCCTCCACTTTTT

CTCGTTCCGCTGTTGTCCCCAATCCTTCTCTTCCTTTAAATCCTTCTGT

TTTACAGGGACAAGTGATGAATAACCCAACCATACCAAΆGGGCACTCCT

TCTACATCCATTGAAGGTGCAAAGACTTCTATCCCACCTTCTCATGCTA

TGCAAAATCCGCΆTAΆCTCTTTCCCTGCATCAGCΆGATAGACTTCAAAA

GAACCACCCTGTTCAATCTTCCAACTTTAACCCGTACACACCTGCACCT

TCGATTACTGTCCCACCTAΆTTATATACCGAACACTGCAATGATGGGCC

CTTCTTATTCTTCTTTTGGTGΆTΆCTGATCCTCGTACTTATCCTGCAGG

AATGGGACCAAACCCTACTGCTGCTAGAAACGGCTTTTATCCTCCAACT

CCGGCCCAGATACATCAATTAAAGGCTCAACAACAGCATCTCCAACGAC

AAAGCAAACAAATGTCGGAGCCTGCTCCTATTAACATGAAATCGAACAA

AGATCAACAATTGCAGTACGTGGATTTTCGAGGTGTTGGTAGTGGCGCC

GATCTTCAAAAACAGCAATGGAACAAATCTACTTCTGCTGAAGGTCTCC

AGCCAAATGGATTGGTTATGAGGAATTTCGGGGACGTTCGCCATCAAAA

GCTTCCTACCTCTTCACCTCCTTCGCAACATCCACCTGTAGGGCAGATT

CCATCACAGTACCTTCCTTATCAGGCTGGGCTCAAAGTGCCAGGTAATA

CACCTATACCCGTTAAACAAGTAGGTGGTATGCCTTTACAATCACCATT

ACCTGTAAGTATGAAGCCTTCCGCAGATGACCATTCACGCGCTACTCCA

ACACGTTCTGTTGAAGCTCCCACTTTGCCGTCATACGCTCCTCGGCATC

CTACTCAΆGCAAATGGATC

SpI; ATGGCTGATCCAGGTTTAAGGTCCGGCGTCGGATTGCCAAGCCAGCAAG 49

Schizo- GACAGAAACATGATTTACAAAAAGATCAAAAACAACCGCACGTAAATAA saccharomyces TGCCGATAGGACCACACAATCCTTACTGAATTCGTACATATATGATTAT pombe; TTAΆTCAΆGAAGGATTATTGTGAGGCAGCCCGAGCTTTTGGCCGTGAAG

NC_003423; CACAAGTACAAACGCTCGTCAGAAGTCAAGAAGAAACCAATTCCTTAGC

19111836 TAAGCGTCACAAAAGAATGTCTCCTGTTGCTGTAAAGCATGAΆGGTATA ΆGTAATAATGAATCTTCGGΆTGAAAACATGAATGTAAATAACGGTAATT TAGATTCCTTTTCTTCTTCTTCTGCTCCGCCGCCACCTCCTATTTTGCC TATCGATTCAGCTGGTGGTTTTTTAATCGAGTGGTGGAATGTTTTTTGG GATATTTACAATGCTCGTCGGGGTCAAGGATCTGAGCCGGCAAAGGCGT ATATGTCTCATATTAGCAATCTTΆGGAAGAAATCTCGTTTAAATTTGCA AGAAATTCAAAAAAACTCTCTACΆCΆCTGGAAΆTACTTCTCACCCTTAT

GCAAACGCCTCATTTCCCCATGATCCTGCCAACGCAATGGGTCAGCAGA

TTGACTCATCTCAGTTTCATCAAGGGGCAGGTGGATTGAACGATAGAAA

TCAGCACTTAATGCGGCAAGCTATGCTAAATAATCAAAGCCGTGAAACG

TTTCCCCCGACCGCTGCTCAACTTCAACAATTAAΆACAATTACACTACA

GGCAGCTACAATCTGTGCAACAACAACAAAAGCAGCACCAGCAAAAGAA

AACTCCACAAAGTGGTTCTACCCCACAAATGCAAAΆCACGΆCTTCTCAA

CCTACAACTCACGATACACATCCACCTAAGCAGCAAGGTCCAATTTCCG

ATTTTCGATCCATCCCTTCTTCACCCAAAACAGAAGGTGCTCCATCTAA

TGCTCAATTTCGCCCTAGTTTACCGGCAΆCTCCTAATGGTTCCGTTCCC

CAGTCGAATCCGTTGTACGATACCACTGGTCTTAACGGAGGACAATACC

CTGTTGTTCAAAΆCTCTGCTCAACCATTGCTTCACGAGATAAATTTTGC

TTCAAACΆGAAATCCACATCTCAAACAAGGAGGAGCΆGTACCTTCTTCT

ACCCTTCCTCAACAACAGAAΆTCTTTAGACAAACCTAAACCTGCTCAAC

AGCCTTCAACTGGGCAATTTTCTGGAAATCAAATGAACCAATACGGATT

CTCTAATTCTCCTTACTCTCAAAATATGCTATATAATTTTAACGGAAAC

GCAAACCCCAGTCGTCTAAACCCAGCTCTCAΆGAΆTTATΆTGGAGGAGT

TAAAGCTACTAGAACAACAGAATAAAAAGAGGCTTCTGTTAGTTAGTCA

GGAAAAAGAAAGAAAAGGGTΆCACATCGGCATCGCCTGATAGACCGCTT

TCTCAGACTATTACTGAATCTAGTGTTGCAAAAACCAAAAGCACTACTC

CTAAATCTACTGACACTCCTACAGAAGCCACCACATCTCCTGTAAAGGT

CTCAACAAAAAATAGTAATACTACTGAAAATCTTAATGGCATCAATGAG

TCAAATΆTGCCTATGTTACAAAΆTGGTCTTCCTTTACGTACATCAGGTG

ΆTCATCCATCΆAACTATTCTAATCTGATTGAAAΆCTCATCTACCTCTGA

CACAAATAATGCGGACAATGGAATGGACGTTATGGGGAATTGGCAATTA

CAACAAACTCATTCATCGCGACCCACTCCAAATGCCΆGTTCTCCATTGG

ΆCGTTCGATCAAAACAAAAGCCTTCTTCTGCTΆΆTTCAAATGCTCCAAC

TCCAGCACCGACCGTCAACACTACCAΆCCCCGAATCATCAACAAATGAA

GCAACAAGTGTAGGTCCTGCTTTGGAACCATCGCAAGGAGCAAATGTTC

ACAAATCCGATTCTGAGTTGGATAΆTCAAAATCAGTCAGGAAAATCAAA

TCCTGATACTTCCGCGACTCCTTCTGCACCTACGGAGTCTACCACAGTT

GCCACTAAATCTTCAGACAATCAATTATTGGATGTTGGAAATTCAACAG

ACATCGATGCGGCTCTTCTAΆATGATTTTGACTTCGACAAATTTTTAAA

AGATACTAGTACTGGTGACGATTTATGGTTTGGATTGTTTAATTTGCCG

GATAATGAAGACTCGACTGCTGCTTAA

Hypothetical ATGTTTGGCAACAATTTCGCTGGCATGTTTGGCCAGCAACAACCCCAGC 50 protein CTAACCCTACTGGTGGCGCTACCGGCACCATGGACGCCAACAACATGAC

UM04381.1; CAGCATCAACCCCGCCATGTTTGGCGGCCTCGACCTCACCACCCTCCAG

Ustilago AACAATCCACAGCTAGCTGCTGCGCTGTTACAACAACAGCAGCAACAAC maydis; AACAACAACAACAACAACAACAGCAGCAGGCTTCGCAACCAAACACTCC

AACP01000154; TCAACAGCCGCGCTTTAACCCGGCCATGTTGAATTCTGCCATGATGGGC

33302112 CTGGATCAGAACAATCAGGCGTCTGGTGGTATCAACATGCAAGCTCTCC

AGCGCGCTGCTGCAGCTGGCGTCAATAATCCCACGGCCTCCTTCAATCC

GCAGATGCTTTTGCAACAACAACAACAACAACAACAACAACAACAACAA

CAACAGCAGCAGCAGCAGCAGCACCAGCAACGCCAAGGCACACCGCAGC

AGCAACAGCCAGGCCAAGTGTCGCGGTGGCCACAACAGCAACAGCAACA

GCAACAGCAACAACAACAACAACCGCAGCAACAGATGCAACAGAATCTG

CTCACACAGCTGCAGAACAACGGAGGTGCCATGTTCAACAACAACAΆCA

ACAACAACAACAACAACAACAACAACAACAACAACAGCAACAACAACAT

CTTTGGTCAGATGGGTGGTATGGGGCATCCACAACAGCAACAGCAACAA

CAACΆACAATCTCAACAGCAGCAGTTTGGTGCCAGCCAATTCAATCCCG

CTGCCTTTGGTCTCAATCCGCAGACTATGGCCTTTTTCCAGCAGAACCC

CATGCAGGCTATGCAAGCAATGCAGACGTTTGGTCAGCTCAATCCTGGT

GCTTTCCCCCCGGGTGCTTTCAACCAACTCATGATGCAACAGCTTCAGC

AGTCCCAAAACCTGTCCGGCGGCTCAAATCAGCCAACTCAAGTCCCCAA

CATGTTTCAGCAGGCTCAAAATGGCAACATGGCTGGCATGCTCGATCCA GCTGCCTTGATGGCGGGTGCATCCAACCCACAACAGCAGCTAGCTATGT

TTGGTGGCGCTGCTCCCGTTCCTGGCTCCTCGCCAGTCCGACCCAACTT

GGCGCTTCAACAACAGCAGCCGCCAAACAGTCTTCCCTCGTATCTGCAG

GCCAACAΆCCAGAACCTGAATCΆGCCCGGTCAATCTTCGCCCGTCGCAA

CACATCAGCAGCCCGGAACGCCTCAGAACAATTCCAGCAACGGTACCGT

TCCTTCCACCCCTACAGCCACCACCAAGCCCAAGCCGCCACGCAAGAAA

GCCGAAAAAAAGTCCACCGCCAAATCGCAGCAAAACCAAAACCAGACAC

CAGTCATGCAACACGCCAATGCTCCTGGTACCACCAGCATGCACCCCTC

TCCCAGCGCTTCATCCGTGACTGGTATGCCGGGTCCCTCACTCCCAGGC

AGCGCTTTCGAACGCTCACGCAGCCATACCCGCTCTCCCAGCGTCTCCT

TGGGCGGTCAAGGAACGCCATCACAGGTACATTCATTGCCTCCCGCCGT

CCAAGCCATGTCACAGCAΆCAACAGCATCAGCAACATCAGCAGCAGCAG

CAGCAGCAGCAGCAGCAGCCACCGCCGATACCGCAACAGCAGCAGGTGG

TCCCGCCTAATTGGATGCCGAGTCTCAATCCGCAACAGCAGCAAGCCGT

CTTGTCCCGAGCGCTGACTCTTGCAAAGGCGCAGGAAGGCTCTGGTTTA

ACACCCGTTCATACACTTATGCΆGATGGGCTACTTGTTCCTCAAGGCTT

CCAGCTTGCCAGGCGGCTCACATCCGTCCATGATGCCCAACGGTGGTAT

GGTGCTCACCATTAATGAGGCGCGCGGACTCAACCTCATCCCTCAGCAA

GGCTCTCAATCAGGACAAACAGGCGCCATGGCACAGCAACATCATCAGC

ATCAGCACCAGCACCAGCAACAGCCTCAGCCTCAGCGGCAGCCTTCCTT

CTCCGGTATGGCGAGCCAGCAACCACAGCAACCACTTGCACCATCACAG

CAGCCACTCGGCTTTGGAGCTCCTCCATTGACGCCGCAGCAGCAACAAC

AACAGCAAATCATGCTCGCCATGCAGCAACAGCAGCAGCACATGCACCC

ACAGTCTATGCACCAACCGCAGGCTCCTCTCGTCGCACCGCAGCTTGGC

CATCCCCACGGCCAGCGATCTACCACGCCAGCAGGTCAGCACGCTTCTC

CCTCGGCCATACATGCGCCTTCACCTATGGGCCCAGCAGGCGCCGTCTC

GAGCCCTGGTATGGCCAΆCAAGTCCCGTCCACGCCAGCCAAGTCTCGCC

CTCAGTACΆTCCAGCCGTCCAGACTCGCGTGGAGGGCTGGCGCCGCCTC

CTTTCCAGCAACAGCCΆCAGCAACAACAGCACCATCAGCCAΆCAGCAGG

CCCTCAAGGTCTGATGGCACCGCCGCCCGCTCCTGGCCACATGCCTCCA

GCTATGGCACCGGGTATGGGCGCCATGCCCCAGGGCATGGTTCCTCCAG

GTGTGCAGGGTGGCCAGCTGCCTCCGGGCTTTGGACCAGCTGGTGCGCC

TCAGATGGGTCCAGATGCGACACCGCCCATGCTCAAGCAGCAAGCACGA

CACCCATCTATGGCGCAGGATCCGTCGCTCGTTGCTACTCCGGAGCACC

CCCGGCCATCGTTGGCTGGCACGGCTGCTTCCAGCATGGACGGCGTTGC

TACCACGACACCGGATCCCATGATGTTGGCCGTAGCΆAGCGCTGCCGCT

GGTCAACCATCGGCTCAATCGCAGCTGATGGGCAGCTTTAGCAGCGCAA

CACCCACACGCAAAGCTCGCAAGGGCTCTCAGCCTGCTCCGACCGGTAC

GCCAGGTGCTGTGTGTACACCTGGCGATGGTGACACACCCGCGCTCTCC

GATGCAGCCGTAGACGCTACGACGGCGACTGGCAAGCCCACAACACTGG

CCGCCAACACTCCCGCTTTCATCCAAACCGTGCCTTCCAACTTGGCCAA

CATGCCCATGCTGCTTGGTGGACCAGCGCCGAAAGAGTCGGCGATCGGT

ACGTCTATTACTCACTTCAATACGCGTGTCACCAAGCTCGACGACGCGA

TGCGTCCTCAGCGTGCAGCCGAAGACGAGGGCGGTGCAGGTTCAAGCCA

AGTCGACAAGGAGGATGGCGATCAAGTGTGGACGCCACTCACGGCGGAA

CAΆGAGGCGGAGCTGGCCAGCATCATGAGGCGCGATCTCGAGTACGAAA

AGCTCTTCCGACAGCAGCAGCAAGAGATGGAAACGTCGCTCAGGCACCG

TATCGACAGCGTAAGGCCGCCACGAAGAΆAGGCGTCAGATGGCAGCATC

ACCAAGCCCAAACCTCTGGCGTGGTGGGAGCGTCCCGAGGAGGAGGATA

CGTCGGGTCTGTCGCGCGATGTGTTCAGACCTTTCGGCGTGCTCTTCCC

GAACCAGAAGCGAGCTGAGCTCGAACAGGGTCAGCGCGGTGCTCGTCCT

CACATTCCTCTGAAGCGCTCGCTCATGGAAATGGTCTCGCAGCAGGGTG

AAGATTTGGTCCCCATTCGCCTCGAGATTGACCACGAGCACTGGAAGTT

GCGCGACACTTTCACGTGGAACGCTCAAGACTCGCACATCAATGTCGAG

GCATTTGCCCAGTCGATTTGCGAGGACATCGGACTGCCTGCGTCCGTGT

TTGTGCCGCAGATCAAAGAGCAAATCACCGCACAGATCCTGGATCACCA GAGCACCAGCGCATTCAAAGCCAAGCCTACGTTTGATTTAAΆCATCGAC

ACCAΆGGAGGGCAAGGGATCGCTCGACGACCAGGACCTTCGCTGGTGGT

CCAAGTGGCGACGCAAAGTTGATCGTCTTCCTTTTGGCGCGGCTTCAGA

ACCACGCGCCAAAGGTGACGGTGACAATGCCGTGATGGAGGTGGACAAC

AGCAGCGAAGAGGACGAGGTGCGATCAGAACCGCCCGAGCTCGTCGACA

CGACTCCGGTCGAGGAACTGCGCATGATGATCAAACTCGATATCACCGT

AGGTGCCATGAATCTGATCGATCAGTTCGAATGGGATGCGAGCGAGTCG

GATCCCGCAGCTGCTGAΆAAGTTTGCCGAGGCCTTTGCCGCTGATCTGG

GCCTTTCGGGCGAGTTCAAAACGGCGATTGCCCATTCGATCCGCGAGCA

GGTCTCTGTACACGTCAAGTCGCTTGCCATGACCGGTCACACGTTTGAT

GGCCGAATGATTGCCGACGAAGAGCTGCGTGCCGCTTTCCTGGGACCTG

TCAGCAAGTCCAΆCTTGTCCAGAGGCGAGΆTCGAGTCGTATCACTTTAC

GCCTCGGCTGCTGCAGCTCACCGAGGCCGAGATCGAGCGACTGGATCGT

GAACGCGAGCGCGAAGCACGTCGAAAACGTCGACAGACGCGTGGTCGCC

GCGGTATCAATCTGCCGGACCGCGATCCTCAAAAGACGCAAAGAACGCC

AGCGGTGTACGGCATCCAGACGGCACAGACGGGTGCGGACAΆCGCTCTG

CAGAGTGTCAATGGTCTCAGCGACCGGTACGGAGGCATGTCAΆCACGGC

GTGCAGCAGCTGCAGCCGCCAACGCCTCAATTGCGCCCTCGCAGGCGGT

CGACATTAGCACGCCCACACCAGGCCCCGATGGACTTGGCCTGCCGGAT

CGCAΆGAAGCCAAAGATCAACCATCACGCGATCCACTTTGACTTTCCAG

GCGGTCTGGGTCGCAAATCGGATCCTGGTGGACCCAAGTTTGCGCCCGA

CTATATGGAAGAGGAGGCCAAGAAGCGTGCGCGTTCACCCGAGAACCAG

GCGACTGGCTCGCAGGTGGAAAAGCCTGCACCGAAGCTGGTCTCGCTGT

CGTATGCGCAGCGCAACAΆTGTGCGACCCGAAGATCTAGAGCGACAGCA

TCCCAACTTCCACGACGGCATGTGGCACTGCTCCAACTGCGGTATTCCA

GGAACGCTCGCGCCAGGTCGACGAAAGGGACCGTTGGGCGACAAGTCGC

TGTGTGGGCCTTGCGGTAAATACTACCACCGTCACCGCAAGGTCATCTT

TTTAGAGTACACGCGCGACCCGGTGGTGCACATGAAGCAGCAGCAGGCG

CTGAΆCCGCAAGATGGGCATTTCGAATCCGCTCATCGATACAGCGCTGC

TCAACGCGTTAGGAGAGCAGGAGGACTCGACCGAGCCTACAAGCGCTGC

GGATACGCCCAAGCCCGACGGCGGCGCTGGAGGCAATGACGATCCGACG

GGCACGGATGACAATGGGATGCGACGCAGAGGACGACCAGCGGCGTCAT

CGCGTGGAGCAΆGTCGTGGAAATGGTGGCGACGACGACGATCGCTCGGA

TGATGAGGATCTGCCGTTTGAGATGGTGGGCAGTCCGGACGATAGCGAC

TCTTCTTCGAGATCGAGCAGCGCTGAGCCCGCGCCTCGTTCGCGCAAGT

CGGCATCGCAGCCGTTGGCGAATGACGAAGGCTCGCAGATCGGGCGACG

CGCAGCCGCCGAGAGCGCACGCGACAAGGTGACGGCTTCATTTGCTGCT

GCTGAAGCTGCTGCGATCAAGACGGAGGCAGACACAGGAGTTGGAGCTA

GCGAAGCTGCCGATGCCAGCAAAGAGGCTGGCGATGCGGTTGCAGCAGC

GACTGCATCGACCGACGCTAACGCCTCTTGCACCAGCAGCACTGGCACT

GGCACTGGCACCAGCAACAGCAACAGCCACAGCGCAGTACCCGTCTCGA

TGACAGAAGTCACAGGCTCACCATCCACAAGTCGTGCAGCTGTCGTTAT

GCCCACGCTCTCCAATGCTTCGCCGCGCATGGCAGCCATCCCTGGCGCC

ACGCCGCCGGACTGGCTCACCGAATCAΆGCGCTGCACTGAAAGCGCGCT

ACCCGAACGACCGGTTCGAGATCCAGCAACGACCGCGTCCCGCTGGCGT

GCCGCCTCCACCACAGCCCGAGTGGCGAGTCCGATGTCTGGACTGTCCT

GGTAAGCTGTATACGCCCGGCCCAGGTGAGAGTCTGACCAACTTTGAGA

TCCACCTGCGCAACCGGTTGCACCGCGCCAACGTCAACAAGCGCGTGTA

TGGCAACAGTGCGCCACCGGCΆGTGGCTGCAGGTGGCGGATCTCCTGGT

GCTGCGGCTGGTTCGCCACACAAGAGTCCGAGCGTGGCTCATGCGCCTG

CGCCGTAG

UM05368; ATGAATCTGCCCCATCAGCCTCCGCGTGACGGCGGTGCTTCACAGCCAA 51 ϋstilago CAGCCTCAGAΆGTGACCCCATCGCCCTGGGAΆGGCGATCACATGCTGCA maydis; CATCTACGTCTGCGACTATCTGCGCAAACGCGGCTACGACCAGGCGGCG

XM_402983; CAGGCTCTCGGCTACGAAGCAGGCCTGGATCCGCAACGTCAΆGTCCCCA

49078465 TCGATGCACCTCAGAGTTTGCTCTTCGAATGGTGGCTCGTCTTTTGGGA AGTGTTTTCGTCCAGAACACGACAACTCGACACAGCTGCCTCGACCAGC

CTTTCCGCAGATGCTTACGCCTACTCGATCCAAAGACCTCCTGGTCTAG

CAGAGGCCAAAACTCCAGCCTCCTCCACTTCAGCCGTTCACAACGTGCC

ATCAGCTTTCACCACGGCCGCACCTCACACCCAAAGTCCTTTTTCGGCA

ACCGTCCAAAACACATCAGTCGCTΆCAAGAACTTCACCGACACGGCAAG

ACTGTTTGAACCAGCCAAATCATGCCTCAAACGCCTCGGCGCCTTTGCA

AGCTGGCGCATCTACACGCACΆTCGCCTCCGAGCCTGCACGTTCTACAA

CAGCAACAGCAACAACAGCAACAACAGCGAAGAGCTTCGTTGTCGACAA

TCCCGCAACTCGATCTCGAGGCAAGTCAGATGCTTGGTCTGACACGACC

CGCGAGCCGTGTTGTCATCCAGCAGTGCATGGACATGATGAACTTGGCT

CCCAAAGAGATCGACCAACTGACGGCGCAAGAGAAGCAAGCGCTTGCCA

AGCGTGTCACACGCCTGCAAAAGGCTCAGAACGATGCGCAGCTGCGGCT

CGCGCAGTTGCACGGTCTGCAGCCTCCAAΆGCCGCTCGTGCCTGCTTCG

CTTGCATCCATACAGACGCAGGCGCAATCACTGTCCGCGCAACTTCAGC

AGGACGGCGCATCGTCGGCCAGCGCACTTGCCAACCAGGCTCACGTCCG

ACGCAAGCGCAΆGGACCCCCCCAATCCAGACGCGGATCGCΆACAGGATA

GGCGCCACACCTGTAGCCACGCAGCCACACGATACCCGACAGATGCAGC

TACAGAAGGTTCGCTCGATGCGACGCGTCTCGTACCCTGCTCTTGCCGC

CGTACCCAGTGCGCCTTCCCCGCTCACGCCGACCAGCAGTGCGACACTT

GCTGGCATTCTGCCGTTCTCGCAAGCATCTCCTCACCCTATGGTGCAGC

ACAGTCCAGCATCGAGCGCTCCCACACCATCCACCCATCCGACCAACCT

GCATGTGCGTCATCCTTCGGTATTGGGTGCCGAACCAGCCGTATTGCAA

GCCCCCAGTCCGCAAAAAGTGTTTATGCACGCTTCTGGTCTCGCCTCGG

TCTCGCCATTTCCAGCGTCATCTGCCAGCCCTCTGGATGAGTGGCACTC

TTTCGACGCGCAGCAGCAACAACGCTTCGCGCCACCATTGCAGCAGCAG

CCACAACGTCCCGTCGTCATGGCGAGCAGTGTGGACCAGCCTACATTTC

AGCCTCAGCCTCAGCCTCAGCCTCAGCCTCAACCTCAACCTCAACCTCA

GCCCGTCATGCTGGATGCAACACGATATCCGCATTCCGGCTTTCCTCAA

GTGTTCTCTGGTCTGCCTTCAGTAGCAGCAAGTGCAAGACCGCCAACTC

ATGCTGTTGGACTCAAAGACACCGCAGCAGCACCGCTGTCGATGCGTCA

GCTCGGCCTGTCAGCGCAGCCCAAACCGTCCGTGTTCGCCAATATCGCC

ACGGGCGGCGATATCAACCCAGCAACAGCCGCTATGGCGTTCAACGGTA

TACCAATAATGCACCATTCAGATCCAGGTGCACCCCTGGCACCTTTCGC

AGACCTCGAGTACGATCTCAACGCCCTGCTGTCCAACACGACTTAG unnamed ATGATGGACCCGCGGCAAGAGACGTGCGGAGACATTGTGTCGACGCGTA 52 protein AΆCGTCGGCTTGAAGAGCTATACTACGTCTCCTTGCACCCTCGGTACCC product; CCAAGGTCTGGATGCCAAACAGAAACTGAAGCAGTTCCAGGACCAGTTC

Yarrowia GACCTGACACAAAACCGACTTTTCGACGAAAACAAATTACCAAAGGCGG lipolytica; TCGAAGAGCCCAAGCCAGTGCCGACCCTTCAAACCTCGACACCTGATGC

CR382130; AGGCTCTTCTCCAGAGTTGAAGCGACGACGTACGTCTAGTATTGCGCAA

49648093 CTGTCACCTACATTCTCACGCACATCACTCAAAACAAACGAGCAGCAAC

TGCAGGAAATGCTGCTGTTTCTGGTGCCCAGCAACATCCCCGAACCCAC

CACAGAAACCAAGTCGCTCGCTGAGCTATACTACACCACACAGACCCTA

CCACTGTCCAAGCTTATTCCGTCGGCGCACAAAACACTTACCACAGACT

CCTACCATCTGGCGTTGCTGGAGGGCAAGCTTGCAGTAGCACATGCTCG

TATAGAGGAGCTGAAGCGGGCAGGGAAATGGGGCCCCAGGCAGCCAAAG

CGGTTCCAGGACCCTATCCGACGGAAAACACACTGGGACCATGTGTTAG

ATGAAATGGAGTGGATGTCTACGGATTTCCGGGAGGAGAGAAAATTCAA

GCAGGCGATGGCTTGTGAAATTGCCTTTTCCGTGCTGGAGTACCACAAG

TACGGTAAGGΆAGCTTGTTGTGTGAAGACGAAGCCTATCAAGTTCCTAC

CAGAGGAAATTAΆCGAGTCTGAΆGATACAGAGAGCAAGATGGACATTGA

TACAAGCATGCCACCACCAAGTATCAACCCTGTTGAGGTGACAΆACATC

TCAGCAGCGGATTCTGTCACTGTTGTTGACTACGΆTACTCTCCTCTCAC

AACCCAGGACACTGTCATCGACTGAGGAGTCTGAAGACAAGCCGGAAGA

GCCTTCTACAGACAGTGAAGAGGTCGTCGGTGGGGAGGTGCCCAAGCGA

CCTGCTGCTCCTAAACTTCCTGAGAGCTCTCCGTTCAAGCTGTACGCCT CAGTGGACAAGCTGGACCCTCTATCCAAGGCTCTCTTTGACAACCTCCC TGTCACTACACCTCCTGGTTCTGCCGTTAATGCTCTACAGGTTCCCTAC

AGCGΆTCCTCTGGACAACTCAAAACTCGCACCTGTCACGCATCTTCTAG

CGGCTCCCCCGGAGCAΆGATGATTGGTGGTCGGTATGTCTTGAAGACTC

TCCTGCCGATGAGGACCCTCTCCCTCTACGΆTCTAACACTCGTTCTACA

CTGTTCAATTCGGAGACCATGCGCCGACATGTCGTCATTAAGGCGCCGC

AGCCTCCACAGACCAΆGTACCTCGACTTCCGAACGCCAACAATGTGGTT

ATTGGCTGATGATTCΆCAGCTTCTTCGACTGGTCAΆGGAGTATTCCTAC

AACTGGGACATTGTGTCTGCCCACΆTGCTGCCCCAAAAAACTTACGGCT

TCACAGCTAACATTGAGAGACGTACGTCATGGCAGTGCTTCGAGCGTTG

GTTCCAGCTCAATCCGACGTTTTCTCTGACGGATTTGCGTGGTCCCTAC

GCTCAGGCTGCCCAGCAATGGATGGCCGCTGCTGCCAAAGCCCAGGCTC

AGTCCAAGCGTCGCATCTCGCCTCTTGGTGTGTCGAATGAGTCTΆTCCA

GAGAGGTCACCGGAAGCTGCGATGGGCTTCCATGTTTGACGGTATTCGA

AAGAGCATGCGAAAACGAGAAACTACCCCCCGACCTAACCCTCAGCCGC

CTCGAAAGTCGCAGCTATCCGAGTCCAACAAGAΆAGATATTGCTTCGCC

TCTGGATCTGTGCAAGATGAAGTTTGAGCAGGATAAGAATCTCGCCAAG

GCTTACGCTCAGCAGCGGATGATGCCTGGTCAGATGCCTGGTCAGATGC

CCCCGGTACCTTCTAACATTCCTGCTAACCGTCAGTTCCCCGGTCAACG

ACCTCCTCCTCCTCAGACCGCGGCTCAAATTCAGGCACACACGCAGGCA

CAGGCTCGAGCTGCTGCTGCCGCCTCTGGACATATGCAGCAGCGTATGG

CTGGTGTGGGCATGAACAGAΆTGCCTGGCCAGATGAACGACCAGCACCA

GATGATGCAGTTTGATCGACAGCGGCAGCTCATGGAGCAGCAGAAGATG

CTGCAACAΆCAGCAGCAGCAGCAGTTTATGCGAACCCAGGGACAGGTGC

CTCCTCAGCCAGGCCAGGTGCAGGGACAGGTGAΆCCAGAACGTCCAGGG

CGCTCAGGTGGCTGCCGGTCAGGCTGGTATGGCTCAGAGACCGGCCGGC

CAGATACCTCAGGGCCAGATGCCTGCTCAACAGGGACAGGTTCCTCCTG

GCCAAGCTGGAAACCAGGCCCAGATGATGCGTCCCAΆCATGCGAATGCG

ACCCGGAGGTCCCCAGGCAGCTGCCCCCAACGAGCATCTGAATGCTCTA

ATTCGCCAGTTGCAGAACCAΆAACCCTGCTTTGTCTCTGGAGGCCGCCA

CCAAGCTGGCGCATGTGCAGGTGCAGCGGTTTGTCCAGAΆGCAGCAGCG

AGTAGCTCGTCAGGCTCAGGGACAGACTCCTCCTCAGGGACAGATGCGT

CCTGGACAGCCCCAGGGACAACCCTCTCCTCAGATGCGTTCGGGTTCTT

CGACTCCCATGAACATGCAATCGCCACAΆCTGATGAACGTACAGCTCCA

ACAGCAΆCAGCAGCAACGGTCTGCTTCACCAGGTCAGΆGCCCCGCCCAG

CAGCACGCCATGCTTATGCGAΆTGAACCAGCAGCAGCAGCAGCAGCAGC

AGCAGCAGCAGAACCAGGGACAGACCCAGGGACAAAACCAAGGACAAGG

TCCATCCGAGTAA

Table 5. Amino acid sequences of C. albicans gene products that regulate hyphal growth.

HYETPRSKQLIALKENASNPNRQSQLQKDQGQTSQQSNQDLKNASGVPN APMFQSTTGTAAAR

CDC24; MEHPPAALRTFSTQSTSSLNSVSTVSSSRIVSSGPVNINNFNKPSTPKD 54

AAO25556; HLFYRCESLKRKLQKIPGMEPFLNQAFNQAEQLSEQQALALAQERSNGN

28192690 GHSNGKRHQSLDGAMNRLSVGSDSSSIQGSLTRMATNASTSSLISGMPN NNTLFTFTAGVLPANISVDPATHLWKLFQQGAPFCVLINHILPDSQIPV VSSDDLRICKKSVYDFLIAVKTQLNFDDENMFTISNVFSDNAQDLIKII DVINKLLAΞYSDASDSGGGDEDVNMDVQITDERSKVFREIIETERKYVQ DLELMCKYRQDLIEAENLSSEQIHLLFPNLNEIIDFQRRFLNGLECNIN VPIRYQRIGSVFIHASLGPFNAYEPWTIGQLTAIDLINKEAANLKKSSS LLDPGFELQSYILKPIQRLCKYPLLLKELIKTSPEYSKQDPHGSSSSTS FNELLVAKTAMKELANQVNEAQRRAENIEHLΞKLKERVGNWRGFNLDAQ GELLFHGQVGVKDAENEKEYVAYLFEKIVFFFTEIDDNKKSDKQEKKSK

FSTRKRSTSSNLSSSTTNLLESINNSRKDNTLPLELKGRVYISEIYNIS APNTPGSTLIISWSGRKESGSFTLRYRSEEARNQWEKCLRDLKTNEMNK QIHKKLRDSDSSFNTDDSAIYDYTGISTSPVNQSTQQQYYDHRGSHSSR HHSSSSTLSMMKNNRVKSGDLSRISSTSTTLDSFSNNLNGSPNTTNPSL MSSDATKTIPTFDVAIKLLYKSTELSEPLIVNAQIEYNDLLQKIISQII TSNLVADDVNISRLRYKDDEGDFVNLNSDDDWGLVLDMLTSEDFYQTSS NEKRSVTVWVS

CHK2; MSMNFFNSSEPARDHKPDQEKETVMTTEHYEFΞRPDVKAIRNFKFFRSD 55 AAC39451; ETETKKGPNLHISDLSPLΞSQSVPPSALSLNHSIIPDQYERRQDTPDPI 29S1066 HTPEISLSDYLYDQTLSPQGFDNSRENFNIHKTIASLFEDNSSWSQES

TDDTKTTLSSETCDSFSLNNASYLTNINFVQNHLQYLSQNVLGNRTSNS

LPPSSSSQIDFDASNLTPDSIPGYILNKKLGSVHQSTDSVYNAIKIPQN

EEYNCCTKASASQNPTNLNSKVIVRLSPNIFQNLSLSRFLNEWYILSGK

HSSKEHQIWSNESLTNEYVQDKTIPTFDKESARFRPTLPINIPGILYPQ

EIINFCVNSHDYPLEHPSQSTDQKRFAMVYQDNDYKTFKELSMFTLHEL

QTRQGSYSSNESRRKSSSGFNIGVNATTTEAGSLESFSNLMQNHHLGAT

STNGDPFHSKLAKFEYGVSKSPMKLIEILTDIMRWETISVIHELGFVH

NGLTSSNLLKSEKNVRDIKITGWGFAFSFTENCSQGYRNKHLAQVQDLI

PYMAPEVLAITNSWDYRSDFYSLGVIMYELVLGILPFKNSNPQKLIRM

HTFENPIAPSALAPGWISEKLSGVIMKLLEKHPHNRYTDCHSLLHDLIE

VKNMYISKLLDSGETIPNSNLNLSDRQYYLTKENLLHPEKMGITPVLGL

KESFIGRRDFLQNVTΞVYNNSKNGIDLLFISGESGRGKTIILQDLRAAA

VLKQDFYYSWKFSFFGADTHVYRFLVEGVQKIITQILNSSEEIQNTWRD

VILTHIPIDLSILFYLIPELKVLLGKKYTSIYKHKIGMGMLKRSFKEDQ

TSRLEIKLRQILKEFFKLVAKQGLSIFLDDVQWCSEESWRLLCDVLDFD

SSGEVRESYNIKIWCYALNADHLENVNIEHKKISFCRYAKQSHLNLRE

FSIPHIPLEDAIEFLCEPYTRSHDHECNSKKSDVIANLNCTNEYPQNTC

KVIPSIIQELYQSSEGNVLLLIFLTRMTKLSGKVPFQRFSVKNSYLYDH

LSNSNYGTTRKEILTNYLNMGTNSDTRALLKVAΆLISNGSGFFFSDLIV

ATDLPMΆEAFQLLQICIHSRIIVPTSTYYKIPMDLIASDQTPFDLTDDN

IWKLATLCSYKFYHDSICTHIIKELNASGEFKELSRLCGLRFYNTITKE

RLLNIGGYLQMATHFRNSYEVAGPEENEKYVEVLVQAGRYAISTYNMKL

SQWFFNWGELVYNLDSKTQLKSVLTIAENHFNSREFEQCLSWENAQR

KFGFDRLIFSIQIVRCKIELGDYDEAHRIAIECLKELGVPLDDDDEYTS

ΞNSLETCLGKIPLSVADIRGILKIKRCKNSRTLLMYQLISELIVLFKLQ

GKDKVRRFLTAYAMSQIHTQGSSPYCAVILIDFAQSFVNETTTSGMLKA

KΞLSIVMLSLINRAPEISLSYVQSIYEYYFSCHAVFFESIEKMSDLIHP

GNASSHCTRSSYYSSFHLIVNVSKIFFSCMNGESFKMFSTFKCKSYLTG

DPQMPEMDNFLYDSΞMLLAGHSELNEFMRKYQSFNQTSVGKFCYYLIVL

LVMSREHRFDEAADLVLKVLEDLSEKLPVSFLHHQYYLICGKVFAYHQT

KTPESEEQVERILARQFERYELWASTNKPTLLPRYLLLSTYKQIRENHV

DKLEILDSFEEALQTAHKFHNVYDMCWINLECARWLISINQKRHRISRM

VKQGLKILRSLELNNHLRLAEFΞFDEYIEDΞDHRNKWAGLTNNPTLDTV

FETLKGLQHLHKKHIIHRDIKSDNVLLDAYGNVKITDFGFCAKLTDQRN KRATMVGTPYWMAPEWKQKEYDEKVDVWSLGIMTIEMIEGEPPYLNEE PLKALYL IATNGTPKLKKPELLSNS I KKFLS I CLCVDVRYRASTDELLE HSFIQHKSGKIEBLAPLLEWKKQQQKHQQHKQETSDTGFA

CRKl ; MSVIAGHHVPRSNDQRQYDTPSVPINIAPDSEGHIHEMSRLKDYEVIEK 58

AAD25159 ; LGQGTFGWQKAKSKKDGSLVAIKQLINHSAKEGFPITAMREITILKQL

4584846 NHKNILTIQDMIFEEPKMSNRTDIITMRGSFYTVTPYMSSDLVGLLENP

KIKLELGQIKCIMQQLLKGIQYVHNQKFLHRDIKAANILIGQDGVLKIA

DFGLARIYHGNVPRLGMGPGGGEKAYTGLWTRWYRPPEILLGERKYTT

AVDQRGIGCVFAELFTGKPILVGKSDSHQAQIVFELVGSPLTWTDAAKL

PNKNEYSCGLACKRSLEAKFASIMPTEAIDLLSGLLTLDPFKRLNALDA

LNHKFFSTDPLPLLPTQMPKFEESHEIDKERFKKLKDKEQAVSELKPPT

EIRYDNHSESRYNADHSTFGGGGVGGKETSFSSGKSDYIDHYΞPRARRD

HYEPRIRNDNKDSNDVRGEFESATRQEQRRRDIQNRLDAGGMDTYIPKT

TTGKLREHSGTESLSQKYDNYQPINVSRGSKSPSPSKLSSISQSKADLI

SKPSAPKVASRESSLERKQVSNGIRTTTDVEPPRARARRPTDMFGRPLT

SNSTQAQPTRNKSVERPKDLEKPTNGVTEDRNKKPVLEEKKEWKPNLA

IPKIKKSSSLVSLSSRSSTTPVISNPSKVTKRAASSVTPPVLPKKPKIS

KTSSESΞVSDLEEDSDFTGENATVFERFMALEQLQKSPVYKRIINEKMR

FEKLSGGHKSM

CYR1/CDC35; MSFLRRDKSKANFRDGSATGLEΞPVSPTTHFSPNVPPPLDGNHGDHYHD 59

CAB60230; PDSPRSSWSLPQLIHNSATHHLKENYRGFHANKRPKGIANVPPLAQPI

7009583 KPRFKKKSNSLLNKLIYSTKKEDDEAATSGKΞSRSSSIISDEKRKSASS

ASSGSSRQKFRFSSFDSNLSTSSSSPPKDKKVSVSDTVSDSSTVTASMS

NMPTISIDLNLDEMHDIIKSPETPTPTAGLPTQKAEKKASPTAIKNWQA

PESWDVKAPIKKEEPHAPKIEEVAENDVAIDNVLEKKRLPVLYGTHQVP

HVTNSKDIKSSHIIRVFKEDNTFTTILCPLETTTSELLAIVQKKFFLES

TTNFQLSVCIGNCVKVLEDFEKPLKIQMGLLLLSGYTEEDKLRMLGRED

LSFVCKFWENIFLRSLTHDEEVLLSRNYVDVNISSLNLKNVPIIFHQH

TYEIEKLNVANNPSIYLPLDFIQGCTSLAYVDFSHNGCSKFPNNLLEAP

QLTHLNLEMNFLDEIPQRISCLSNLTNLKLSSNQLYSLPHSFSTLTNLK

QLDLSSNYFDSYPEAVNKLTNLVELNFSYNDLSIIPΞSIANLINLQKLN

LCTNKLSGTLPGYLSQLKALKRLDIRYNYISNVDVLGIIPNLEVAYASK

NAISTFSDQMKCLRLLHFDRNPITELKFNTQMQMLSVLDLSRAKITAFP

AEFVEKVPNIEKLVLDKNHLVSLPNELCQLSKLVSLSVHANNLQSLPAN

IGDLRFLKYLDLHSNNLKSLPDQIWDLCHLTSLNVASNNLTSFPKAPYS

WKRLSSSLVDVHLESSQTLSLADSLLILILSDNRLSDDCFDEISFLIA

LKSLNVSYNDLIEIPQGTLSRLTRLNELYLSGNELTTLPADDLEVLKSL

KLLYMNNNKLVSLPAELSRIANLQHLDVSSNQLKYNISNWPYDWSWHWN

KNLKYLNFSGNKRFEIKQSHIKNPETGEDFDSLLVLKQLRVLGLIDVTL

TTTNVPEQAVDLRLRTTASΞFDNFGYGVSDSLGMRDHVSARDLFVQKFR

GKENEMLLCAFDGKHGATNQGHRISLVAKNMFVRNFTKELDEIKSDDEI

ENALRKAFLNFNKEINGILTAKKNKSFTPVPNMSKEALELNLVDDGNAG

CTVSVIYIKDKKLYSANIGDIEALLCRNNGDQFLLTEKHDPTNREEFER

IRASGGYVSGGGELDGQLSVSRGVGFFNFLPHTHCGPTIRRFKITNDDD

MIILGSKQLWDFISYESAVDIIRKDKNDPMVAAQKLRDFAICYGATDKI

CVIVLTFGNRQKQAANMYSNYGVDRRRRDKQQWGGDSNLRKLΞQEIEP

PIGPLALVFTDIKNSTLLWDSYPAPMRSAIKIHNTIMRRQLRITGGYEV

KTEGDAFMVAFPSPTAALLWCFQVQQNLVTADWPSEILETDQCCWSDS

ENNTIFRGLSVRMGIHWGSPVCEPDVITGRMDYFGPMVNRΆSRISAIAD

GGQIAVSSDFLDVLNSLTVKHNNIKNNVESLIDAYQGKFENAGMTIEREL

NALEDLGCNYFKIGERKLKGLETPEPITLVFTNRLKLRYDIFQKRLDAN

HSTRVAGTLPVEIIYGLRTVSLRLENLCSSINNGGNYCSEGFESSSGVI

SQKMNSSFKDSDLISLLNHVTTRIESCTTTLFLRQQLSQIKGNGGLIET

NNSPSLDVIMDEVADIMKTVNELK

EFGl; MSTYSIPYYNQMNGNYNNGMPQQTTAANQQAFPQQQQPTTTGNASQQQQ 60 CAA83640; QAAATAAAVQQPYNYMFYQQQGQPGQQTGQTAGQQQQQQQQQQQYDYNT 832907 YNRYQYPAΆTSQGNYYQQTIPNQLSQPQPQHYNGSNRNYTSΆPSGAPIP SNSTSGPSQQPPLPGQQAVPIPPHVSTMQQPTPVQDTLNASSTSTVGQF QPPGIRPRVTTTMWEDEKTLCYQVDANNVSVVRRADNNMINGTKLLNVA QMTRGRRDGILKSEKVRHWKIGSMHLKGVWIPFERALAMAQREQIVDM LYPLFVRDIKRVIQTGVTPNAAAATAAAAATATSASAPPPPPPPVAAAT TTAATAISKSSSGNGNSISATSGGSNVSGASGAGSTTSPVNTKAATAAG IPQGNYYQTYNQQQYPQQYGQYNAPGKNQNTPASQPGSTTNDQYLQQQQ QQQQQMYGYQSNYYQGGAANSSYYPNYYQQQQPNYASSYPYQQQQQKQQ QQQPNQQQQSDQQQTSTPSGGAGTRSVHQSPQVQSLTQGSVHPSPQQHQ ANQSASTVAKEEK

ERG24; MKSSKLNPVTTHKEFNGISGALGITIGLPTLTVLFYLLCNQTYSIHGIN 61

EAK91422; VDFAKIKSQLPITQDELWQLVFDKTCWSAYLAWFFILVILDYLLPGKSL

4S431903 NGVKLRDGTVLNYKINGLSMGSLLIVLLLARLFQSNSDSSLEYYLPELQ FIYDNQLQLIIICFLFSFMLAVFVYIISFIPLAKPNGIGTKΞRILSING NTGNPFYDWFIGRELNPRIGSWDIKLFCΞLRPGMLLWLLINLSCLHYQY HNLGYVTDSMIWNLLQAFYIFDGVLNEEGCLTMIDITTDGFGFMLSFG DLAWVPWTYSLQARYLSIKGNEVNLGWTLSLLIVGLQALGFYIFRSANK QKSDFRQGKLPHLKSIQTKTGSKLLVEGWWGLSQHINYLGDWLIGLSWC LPTGFQTPLTYFYVIYFASLLIHRQVRDEMKCRAKYGEDWEKYEKLVPY KIIPYVY

FAS2; MKPEIEQELSHTLLTELLAYQFASPVRWIETQDVFLKQHNTERIIEIGP 62

AAA34345; SPTLAGMΆNRTIKAKYESYDAALSLQRQVLCYSKDAKEIYYKPDPADLA

456443 PKETPKQEESTPSAPAAATPTPAAAAAPTPAPAPASAGPVESIPDEPVK

ANLLIHVLVAQKLKKPLDAVPMTKAIKDLVNGKSTVQNEILGDLGKEFG

STPΞKPEDTPLEELAEQFQDSFSGQLGKTSTSLIGRLMSSKMPGGFSIT

TARKYLESRFGLGAGRQDSVLLMALTNEPANRLGSEADAKTFFDGIAQK

YASSAGISLSSGAGSGAGAANSGGAWDSAALDALTAENKKLAKQQLEV

LARYLQSRLKQGSLKSFIKEKEASAVLQKELDLWEAEHGEFYAKGIQPT

FSALKSRTYDSYWNWARQDVLSMYFDIIFGKLTSVDRETINQCIQIMNR

ANPTLIKFMQYHIDHCPEYKGETYKLAKRLGQQLIDNCKQVLTEDPVYK

DVSRITGPKTKVSAKGNIEYEETQKDSVRKFEQYVYEMAQGGAMTKVSQ

PTIQEDLARVYKAISKQASKDSKLELQRVYEDLLKWESSKEIETEQLT

KDILQAATVPTTPTEEVDDPCTPSSDDEIASLPDKTSIIQPVSSTIPSQ

TIPFLHIQKKTKDGWEYNKKLSSLYLDGLESAAINGLTFKDKYVLVTGA

GAGSIGAEILQGLISGGAKVIVTTSRFSKKVTΞYYQNMYARYGAAGSTL

IWPFNQGSKQDVDALVQYIYDEPKKGGLGWDLDAIIPFAAIPENGNGL

DNIDSKSEFAHRIMLTNLLRLLGAVKSKKPTDTRPAQCILPLSPNHGTF

GFDGLYSΞSKISLETLFNRWYSEDWGSKLTVCGAVIGWTRGTGLMSANN

IIAEGIEKLGVRTFSQKEMAFNILGLLTPEIVQLCQEEPVMADLNGGLQ

FIDNLKDFTSKLRTDLLETADIRRAVSIESAIEQKWNGDNVDANYSKV

MVEPRANMKFDFPTLKSYDEIKQIAPELEGMLDLENWWTGFAEVGPW

GNSRTRWΞMEAYGEFSLEGAIEMAWIMGFIKYHNGNLQGKPYSGWVDAK

TQTPIDEKDIKSKYEEΞILEHSGIRLIEPELFNGYDPKKKQMIQEIWQ

HDLEPFECSKETAEQYKHEHGEKCEIFEIEESGEYTVRILKGATLYVPK

ALRFDRLVAGQIPTGWDARTYGIPΞDTISQVDPITLYVLVATVEALLSA

GITDPYEFYKYVHVSEVGNCSGSGMGGVSALRGMFKDRYADKPVQNDIL

QESFINTMSAWVNMLLLSSSGPIKTPVGACATAVESVDIGIETILSGKA

KWLVGGYDDFQEEGSYEFANMNATSNSIEEFKHGRTPKΞMSRPTTTTR

NGFMEAQGSGIQVIMTADLALKMGVPIHAVLAMTATATDKIGRSVPAPG

KGILTTAREHHGNLKYPSPLLNIKYRKRQLNKRLEQIKSWEETELSYLQ

EEAELAKΞEFGDEFSMHEFLKERTEEVYRESKRQVSDAKKQWGNSFYKS

DPRIAPLRGALAAFNLTIDDIGVASFHGTSTVANDKNESATINNMMKHL

GRSEGNPVFGVFQKYLTGHPKGAAGAWMLNGAIQILESGLVPGNRNADN

VDKLLEQYEYVLYPSRSIQTDGIKAVSVTSFGFGQKGAQAWVHPDYLF

AVLDRSTYEEYATKVSARNKKTYRYMHNAITRNTMFVAKDKAPYSDELE

PLDl; MSPTAEQPISPLDENPLDENVNNSKLKASSANDKEDGSYNLKAVQQDGT 69

BAA32278; IDDNDALRKSSDIDRIFRSVHSGPILPEHRSPSPNTRDDSSQVIGNPLS

3413518 FYYSNDDKESRYDEDRSQRQSLGKNKYPEDEQQLPNRFELVDDEDINKA

PPRKESSRPTHSRSATLSGFMQSRILGRSTSTNQEMPNTEPEPANLHDA

LHPREDSTKSGRFIKTLRRFNRRKTKDKRQSTMTAEFDELNDESΞNATI

ERAEKLLAGMSTGAPAINLMASCLLEDEHGITRAPLLLSVLGFKLSDVT

PKETSRNRRFRIDLEYGIDKHRMKWSIERNATDLAYLAYKLERTRIVSR

WGNKSQPLPRLPIPPIRKLDNKRSKKTKSVLSDSRARDDRMSVPDIND

NHSLSPVPSALSRVRSRLGSITSVGSLEKHPELLELRRKKNAQFMKDVE

SYLKELIEITELKTSANILFTFFELSPLSSLLSYESGYTGKQGPVHIGG

TAKAQGWRVGHFKVNDLKGIYERRVEKWMLVRNSYITYVSDINSTTPLD

VFLVDSDFKISARNLΞIANRDDDDSLFDNSSVAQQQMHENENKFFPHLK

ITLENRERKLVMSPKSQREHSLWIDSLRTMQNSTIWSQNKRFDSFAPVR

ENCFAQWFVDARDYFWAVSTALEMAKDTIMIHDWWLSPELYLRRPANGN

QQYRIDRLLQRKAKEGVKIFVIIYRNVGTTVATDSLYTKHSILSLDEEN

IHVIRSPNQLLQNTFFWAHHEKLCIIDHTYAFLGGIDLCYGRYDTPDHA

LTDDSGVDFSNIAQDDRITAENFANFQVFVGKDYSNPRVKDFSELEKPY

ESMYNRNIVPRMPWHDVHMYTCGQTARDLSRHFVQRWNYLIRQKRPSRL

TPLLLPPSDLTΞEEVLAHGLDGTCEVQLLRSSGNWSLGLKEHEQSIQNA

YLKLIETSEHFVYIΞNQFFVTACFIDGTEIKNRIGDALVDRIIRAHREG

TNWKAIIVIPLMPGFEAQVDEAEGSSVRVIMQCQYMSISRGETSIFAKL

RKKGIDPDQYIQFFSLRKWGRIGSNRTLVTEQLYIHAKTMIVDDRSVII

GSANINERSMRGLRDSEVAAWRDKEMVKSKMNGKPYMAAKFAHTLRMR

LMREHLGVNIDIVDWERRFKRFENFAASEEGKKFATNKFRNPENRTLS

AMVEIASRDILQQPΞGTRRWKEFIHVSKYDAEIAEVNFEEEDTSLPPPL

FLPISFNNRTGPFEANKGVRDSKKHSYDNRVQNSESHKKDVYGEGLDKY

RSKLAKRARVSSGKFLNELSLLAMETNPTGSFLPDFDSVRNFLESDDCH

MSGEMDDESEDIIAERNKERWMLLKKISYLQRLAAREKSMNDTENQKRA

KLGLPLLSKTGNAVNGNESQELPVSATLPISEGIDTDFSLDKEFPTVSL

SEPAARDIINNLTTPDAΆVSNFVDPYEFEDPIDPDFYEARWNEFARRNT

DIYRMVFHCQPDDWGRWSEYTHFTKLQSMFMKAQDTDTDQGQSAENYS

DEKVΈAGDNQEPRRANNSKLEKIDEASEDEYGLLGKAPPERGLENQNKS

EQETNLRΆKLSRRVSTFAGVTENRDKHFSDKAΆPKSEGELQGGEKTSTE

EEESEESGTPTDKPSATAGTVPASKTRKRARTYLARRKIQTGDWYDKN

SAERLLNAVQGHLVYFPAEWLSVELRNNNWFYNTDRLPPMEIYD

PMTl; MAKKPVTPASKVAAKQAAVRSRHQEDVFTLDPLIDPIFQKGELRSYLVT 70

AAC31119; EPSPSVLKKRSIHTKEYWMLSSLLLIAFYVRMYNLSNPNSWFDEVHFG

3411013 GFARKYILGTFFMDVHPPLAKMLFGΆVGAIGGFKGDFEFKSIGDKFPDS

TPYIFMRQFPALLGVGTVILCYLTLRQSGVRPIIAYITTFLLIIENSNV

TISRYILLDSPLIFFIAΆAIYAWKKFEIQIPFTFGWYRSLLATGIALGL

ALSSKWVGLFTVAWVGFLCIYQLWFLIGDLSVSTKKIWGHFFARGIILL

GVPIALYLGFFAIHFQLLNKEGDGGAFMSSAFRAGLQGNKIPRDITEQV

GLGSWTIRHVDTQGGYLHSHEHFYQTGSKQQQITLYPHLDSNNKWLIE

PYNGTIHNETFVPLINGMKIRLKHINTGRRLHSHDEKPPVSERDWQKEC

SCYGYDGFAGDANDDWWEIVNYRSQKGEAQTFVKAINTIFRLRHAMTG

HYLFSSEVKLPEWGFGQQEVTSASQGKRALTHWYIETNENSILPPSEAK

IINYPKLSLWQKWESHKRMWKINQGLTSHHHWQSSPSΞWPLLLRGINY

WNKEHKQVYLLGNAVTWWAATLSIITFGTYVLVTVFRWHLGTPLSTNKH

VFNFNVQTFSYVLGWALHYLPFFIMGRQLFLHHYLPALYFGILALGHFF

EIFTGYLTSRSKYFQQVAFVLVGLFSILSLVFYVNYSSLIYGTPWTKAS

CΞLTKPFSGWDYNCGTFFDTLGEYDIQEKSLASESEIPTETWVEAKQT

PKAEPKLAKQDDHIESPAAAEPVEΞKEVKEEVEQLAPPLAVDFEEETPK

VEDPQVADVDASSNDEKSVEEKQQQEQQQEQEQVEDESVHQVQQ

SLNl; MΞRDLTYNAPKIKFTDTEGQEEHFYFNRSNNSTNDLTSHDSSSTQLQDA 71

BAA19594; NSRRQAPPPPPHNPFSDNSHENSTESLYQSΞTRFHQPLLHNDSNNSNSS

1944426 IGMNRQRIPSQQHDTSSLYSASPISTSPLVSNFQSYSDNQDEMTRGKYN

KSYCFITYTTLRKNSNLILNLFQLMLDANIPDIQFDPSRVIEKVQEKFC LQMTEEEAILHFQNLINDSVNAFLPWIDRLHSLAQYWRA

Table 6. DNA sequences of C. albicans genes that regulate hyphal growth

CGATCCAAAGATTGTGTAAATACCCACTTTTGTTGAAAGAGTTAATCAAAACA

TCACCAGAATATTCAAAACAGGACCCCCATGGCAGCTCGTCATCGACATCATT

CAATGAATTATTGGTGGCTAAAACTGCAATGAAAGAATTGGCAAATCAAGTCA

ATGAGGCGCAAΆGACGAGCAGAΆAATATCGAACATTTGGAAAAACTAAAAGAA

AGAGTAGGTAATTGGCGTGGGTTTAATTTGGΆTGCTCAAGGAGAACTATTATT

CCACGGACAAGTTGGGGTTAAAGATGCTGAAAATGAAAAGGAATACGTTGCTT

ΆTCTTTTTGAAAAAATCGTATTTTTTTTCACAGAAATTGATGATAACAAAAΆA

TCTGATAAACAGGAAAAGAAGAGCΆAGTTTTCGACAAGAAAGAGATCAACTTC

ATCAAATCTTAGTTCATCGACTACTAΆTTTGTTGGAATCAATAAACAATTCCC

GAAAGGATAACACATTGCCATTGGAATTAAAGGGAAGAGTTTATATATCGGAG

ATTTATAACATTTCCGCACCAΆΆCACTCCTGGCTCAACTCTAATCATCTCATG

GTCAGGTAGAAAGGAAAGCGGCTCATTCACTTTGAGATATCGTAGTGAAGAAG

CCAGAAACCAATGGGAAAAGTGTTTACGTGATTTGAΆGACTAATGAAATGAΆT

AAACAAATTCATAAGAAGTTACGTGATTCCGACCTGTCATTTAATACTGATGA

CTCTGCCATATATGATTACACGGGTATTAGTACGTCACCAGTCAATCAATCAA

CTCAACAACAATACTATGATCATCGGGGCTCTCACAGTTCCCGCCATCACTCA

TCGTCATCCACTTTGAGTATGATGAAGAATAATAGAGTTAAATCTGGTGATTT

GAGTAGAATATCTTCAACTTCAACAACATTΆGATTCTTTCΆGTAACAACTTGA

ATGGGTCACCAAATACCACTAATCCATCTTTGATGTCTTCAGATGCCACCAAA

ACAATTCCAACATTTGACGTTGCAATTAAATTGCTTTACAAATCGACAGAATT

GTCAGAGCCATTGATTGTCAATGCACAAATTGAGTATAATGACCTTTTACAGA

AAATTATCTCCCAGATTATCACTTCGAACTTGGTGGCAGATGATGTCAATATT

AGTCGATTGAGΆTATAAΆGACGACGAAGGAGACTTTGTGAATTTGAATTCAGA

TGATGATTGGGGGTTAGTGCTTGATATGTTAACCAGTGAAGACTTTTACCAAA

CATCAAGCAATGAAAAACGACTGGTGACAGTGTGGGTTTCTTGA

CHK2; ATGTCTATGAACTTTTTTAATTCAAGCGAΆCCTGCAΆGGGACCACAAACCGGA 77 AFO13273; CCAGGAΆAAGGAAACAGTAATGACGACAGAACATTATGAATTTGAACGACCAG 2961065 ATGTCAAAGCTATACGAAATTTCAAΆTTCTTCAGGCTGGACGAAACAGAΆACC

AAAAAAGGACCAAACCTTCΆTATTTCGGATCTATCCCCTCTTGAATCACAATC

TGTGCCCCCTTCAGCCTTAΆGTTTAAATCATTCGATAATACCAGACCAATATG

AACGACGTCAGGATACACCGGATCCTATACACACTCCTGAAATTTCATTAAGT

GATTATTTATATGATCAGACATTGAGTCCCCAΆGGTTTTGACAATAGCCGTGA

AΆATTTCAΆCATCCACAAΆACAATCGCCAGTTTATTCGAAGATAACTCATCTG

TTGTATCACAAGAATCTACTGATGACACCAAGACAACATTATCACTGGAAACA

TGTGATAGCTTTTCATTGAATAACGCATCATATTTGACCAACATTAACTTTGT

GCAAAATCATTTACAATACCTTAGTCAAAATGTTTTGGGAAATCGCACTTCCA

ACAGCTTACCGCCATCATCATCATCACAGATAGACTTTGATGCCTCCAATTTG

ACACCCGATTCGATACCAGGGTACATTCTCAACAAGAAACTTGGCTCTGTTCA

TCAACTGACAGACCTGGTATACAACGCTATCAAGATTCCTCAAAACGAAGAAT

ACAΆCTGTTGCACTAAAGCTTCTGCTAGTCAAAATCCAACAAATTTGAATTCT

AAΆGTGATAGTGAGGCTATCACCTAATATTTTTCAAAACTTGTCACTTTCGCG

TTTTCTTAATGAGTGGTACATATTATCTGGGAAGCACAGTTCAAAAGAGCACC

AAATATGGTCCAATGAGTCTCTCACAAATGAATACGTACAAGACAAAACAATT

CCGACATTTGATAAAGAAAGTGCACGTTTTAGACCAACGTTGCCCATAAATAT

ACCAGGTATCTTGTACCCGCAAGAGATAATAAACTTTTGTGTGAACAGCCATG

ATTATCCACTTGAACACCCATCACAGTCCACTGATCAAAAAAGATTTGCCATG

GTGTACCAAGACAACGATTACAAGACATTCAAAGAACTCAGCATGTTCACTTT

GCACGAGCTACAAACTAGACAGGGGTCGTATTCGTCCAACGAGTCACGACGAA

AΆTCCAGCAGTGGCTTTAATATAGGTGTCAATGCAACCACCACTGAAGCTGGG

TCTTTGGAATCTTTTAGTAATCTAATGCAGAΆTCACCATCTTGGTGCAACTTC

AACCAACGGAGACCCATTTCACTCAAAACTAGCAAAGTTTGAGTATGGAGTTT

CCAAATCCCCTATGAAGCTTATAGAGATTTTGACTGATATAATGAGAGTTGTC

GΆGACAATAAGTGTTATTCATGAACTAGGATTTGTTCACAATGGCCTAACTAG

CAGCAATTTATTGAAGTCAGAGAΆAAATGTCAGAGATATAAAAATAACAGGAT

GGGGGTTTGCATTCAGTTTTACTGAAAATTGCAGCCAGGGTTACAGAAATAAA

CACTTGGCACAAGTCCAAGATTTAATACCTTACATGGCACCAGAGGTGTTGGC TATTACAAATTCGGTTGTGGATTATCGGTCGGACTTTTACTCGTTAGGGGTAA

TAATGTATGAGTTAGTTTTGGGTATTTTGCCATTCAAAAATAGCAACCCCCAG

AAATTGATCAGAATGCATACTTTTGAAAACCCΆATAGCTCCCAGTGCTCTAGC

ACCAGGTTGGATTTCAGAGAAATTGAGTGGCGTTATTATGAAATTGTTAGAGA

AGCACCCACATAACAGATACACCGACTGCCACTCATTGCTCCACGATTTAATT

GAAGTTAAAAATATGTACATTAGCAAATTATTGGATTCAGGGGAAACAATCCC

CAATΆGTAACCTAAATTTAAGTGATCGCCAGTΆCTATTTGACTAAAGAAAATT

TACTTCATCCCGAGAAAATGGGAATTACTCCTGTΆCTTGGGTTGAAΆGAAΆGT

TTTATTGGAAGAAGAGATTTCTTGCAAAATGTTACTGAAGTTTACAATAACAG

CAΆAAATGGGATTGATTTACTTTTTATATCCGGTGAAΆGCGGAAGAGGTAAAA

CGATAATΆTTACAΆGATCTTCGAGCAGCAGCAGTTTTGAAACAAGACTTTTAT

TACTCATGGAAGTTTAGTTTTTTTGGAGCAGATACACATGTGTACCGGTTTCT

TGTTGAAGGTGTTCAAAΆGATTATTACCCAGATTCTAAATTCTTCAGAAGAAA

TTCAAAATACATGGAGAGATGTGATTTTGACACACATTCCTATAGATCTAAGC

ATATTATTTTATTTGATTCCTGAGCTAAAAGTACTATTGGGGAAAAAATACAC

TTCCATTTACAAACATAAAATTGGAATGGGGATGCTAAAGAGAAGTTTCAAAG

AAGACCAAACACTGAGACTAGAGATTAAATTGAGACAAATACTAΆAAGAATTT

TTCAAACTTGTAGCGAAACAAGGCTTGTCTATTTTTTTAGATGATGTACAGTG

GTGTTCAGAAGAGTCCTGGAGGTTATTATGTGATGTATTAGATTTTGATTCAT

CTGGAGAGGTGCGAGAGAGCTATAACATCAAAATAGTTGTGTGCTATGCTTTG

AATGCAGACCATTTAGAGAATGTTAΆTATCGΆGCATΆAΆAAGATTTCTTTTTG

CCGATATGCCAAACAAAGCCACTTAAATTTGCGTGAGTTTAGTATACCTCATA

TCCCACTTGAAGACGCTATTGAATTTTTGTGTGAACCTTACACGΆGACTGCAC

GATCATGAATGTAACAGTAAAAAGTCTGATGTAATTGCCAATTTAAACTGCAC

AAATGAATATCCTCAGAACACTTGCAAAGTCATCCCCAGTATAΆTCCAAGAGT

TGTATCAATCATCAGAΆGGGAΆTGTTTTGCTTTTGATATTCCTAACAAGAATG

ACAAAGCTATCTGGCAAΆGTTCCCTTTCAACGATTTTCGGTCAAAAATTCΆTA

TCTATATGATCACCTACTGAATAGTAACTATGGAACTACAAGAAAAGAGATTC

TTACAAATTATTTGAATATGGGAACTAΆCTCAGACACAAGAGCCTTGCTTAAA

GTTGCAGCGTTAATCTCCAATGGATCGGGATTCTTTTTTTCAGATTTAATTGT

AGCCACCGACTTGCCCATGGCTGAAGCGTTTCAGTTGTTACAAATATGTATTC

ATTCCAGAATAATTGTTCCTACTAGCACATATTATAAAATACCTATGGATTTA

ATAGCCTCTGACCAGACTCCATTTGATTTAΆCAGATGATAATATTTGGAAACT

AGCCACTTTATGCAGCTACAAGTTCTATCATGATTCTATTTGTACTCATATAA

TCAAAGAATTAAACGCCAGTGGCGAATTCAAAGAACTTTCTCGGTTATGTGGG

TTGAGATTTTACAATACAATTACAAAAGAACGTTTATTAAATATTGGTGGCTA

TCTTCAAATGGCTACTCACTTTAGAAACTCATACGAGGTGGCAGGTCCCGAAG

AAAATGAAAAGTATGTTGAAGTTTTGGTCCAGGCAGGACGATATGCCATATCG

ACATATAATATGAAGTTGTCTCAATGGTTTTTCAATGTTGTTGGCGAATTGGT

ATATAΆTCTTGATTCGAAAACTCAGTTAAAΆTCCGTGTTAΆCAATAGCCGAGA

ATCATTTTAATTCTCGTGAATTTGAACAATGCCTΆAGTGTGGTTGAAAATGCA

CAGAGGAAATTTGGTTTTGACAGGTTGATATTTTCCATTCAAATAGTCCGTTG

CAAAATTGAATTAGGTGATTATGACGAAGCACATCGAATTGCAATTGAATGTC

TTAAGGAATTAGGTGTTCCATTAGATGACGATGACGAATATACAAGTGAAAAC

CTGCTTGAGACGTGTTTGGGAAAAATTCCGCTCTCTGTTGCTGACATTAGAGG

TATTTTGAAGATTAAAAGATGCAAGAATTCAAGAACATTGCTAATGTATCAGT

TAATTTCAGAGCTAATTGTACTATTCAΆGCTTCAAGGTAAAGACAAΆGTGAGA

AGGTTTCTCACAGCTTATGCGATGAGTCAΆATTCATACTCAAGGGTCTTCTCC

TTATTGTGCAGTAATTCTTATAGACTTTGCACAATCATTTGTCAACGAAACCA

CAACTTCAGGAATGCTTAAAGCAAAAGAACTCAGTΆTTGTCATGTTGTCATTG

ATTAATAGAGCACCAGAAATATCTTTATCATATGTTCAGTCTATTTATGAATA

TTATTTCAGTTGTCATGCTGTATTTTTTGAATCAATTGAΆAAΆATGCTGGATC

TTATACATCCAGGTAACGCTAGTTCCCATTGCΆCAAGΆCTGTCTTATTATTCA

TCTTTTCATTTGATAGTTAATGTTTCCAΆGATTTTCTTTTCATGTATGΆΆTGG

AGAAAGTTTCAAAATGTTCTCAACATTCAAGTGTAAATCCTATTTAACAGGGG

ATCCCCAAATGCCTGAAATGGACAΆTTTTTTATACGΆTAGTGΆAATGTTACTT GCTGGACATTCAGAATTGAATGAATTTATGAGAAAATATCAGTCATTCAACCA

AΆCTTCCGTTGGTAAATTTTGCTACTΆTTTAΆTTGTACTACTTGTAATGTCAC

GTGAACACAGATTTGACGAGGCTGCCGATTTGGTTTTGAAAGTTTTGGAAGAC

TTACTGGAAAAATTGCCTGTATCTTTTTTGCATCATCAATATTACTTAATATG

TGGTAAAGTGTTTGCTTATCACCAGACCAAAΆCCCCAGAAAGTGAGGAACAAG

TGGAACGTATTTTGGCTCGTCAATTTGAAAGATATGAATTGTGGGCACTGACG

AATAAGCCGACCCTTCTACCACGGTACTTGTTGTTGAGTACCTACAAACAGAT

TAGAGAAAACCATGTTGACAAGTTAGAAATACTAGATTCATTTGAGGAGGCGT

TACAGACGGCCCATAAATTTCATAATGTATATGATATGTGCTGGATCAATTTG

GAATGTGCAAGATGGTTAATTAGCATAAACCAAAAAAGGCACAGAATCTCAAG

AATGGTTAAACAAGGTCTTAAAATTTTGAGAAGCTTGGAATTAAATAATCATT

TAAGATTAGCTGAATTTGAATTTGATGAATACATTGAGGACGAAGATCACAGA

AATAAATGGGCAGGGTTAACTAATAΆTCCΆACATTGGATACTGTTACTACCTG

GCAACAACAGAACATGCCCGATAAGGTATCTCCATGCAATGACAAGCAGTTGG

TCCΆCGGAAAACAATTTGGCAAAAAAGAGTTTGATAGCCATTTGCTCAGATTG

CACTTTGATGGCCAATATACAGGCCTAGATTTGAATTCAGCTATTCGTGAATG

TCTAGCAATATCCGAAGCTTTAGACGAAAATTCCATTCTCACAAAGTTGATGG

CATCTGCCATCAAGTATTCAGGTGCCACATATGGGGTAATTGTCACGAAGAAA

AACCΆGGAGACACCTTTTCTTAGAACΆATTGGCTCGCAGCACAATATTCACAC

ATTAAACAACATGCCAATTTCCGACGACATTTGTCCTGCTCAGTTGATTCGTC

ATGTATTGCATACAGGAGAAACGGTGAACAAAGCTCATGATCACATAGGATTT

GCTAACΆAGTTTGAGAΆTGAATACTTTCAΆACAΆCAGATAAAAAGTATTCAGT

TGTGTGTTTGCCATTAAAGAGTCTGCTTGGATTATTTGGTGCACTTTATCTAG

AΆGGTAGTGATGGTGΆTTTTGGACATGAAGATTTGTTCAATGAAAGGAAATGT

GATTTGTTACAACTTTTTTGCACACAAGCAGCTGTGGCTTTGGGTAΆGGAGCG

TTTGCTTTTGCAAATGGAACTΆGCAAAAATGGCAGCAGAAGACGCCACTGATG

AAAΆAGCCAGTTTTTTGGCAAACATGTCACATGAAATACGAΆCCCCATTCAAT

TCGTTATTGTCATTTGCTATTTTTTTGTTAGATACCAAATTGGATTCTACTCA

AAGAGAATATGTCGAGGCAATTCAGAGCTCCGCAATGATAACGTTGAATATTA

TTGATGGGATACTTGCGTTTTCCAAAATTGAGCATGGATCCTTTACATTAGAA

AATGCCCCCTTTTCTTTGAATGATTGTATCGAGACTGCTATTCAAGTAAGTGG

GGAAACAATTTTGAATGACCAGATTGAGTTGGTGTTTTGTAACAATTGTCCAG

AGATTGAATTTGTGGTTGGTGATCTAΆCGAGGTTCAGACAAATTGTGATCAAT

TTGGTGGGTAATGCTATTAAGTTTACAACCAAAGGTCΆTGTTTTGATTTCTTG

TGATAGCCGAAAAATTACGGACGACAGATTTGAGATCAATGTGTCAGTTGAGG

ATTCAGGAATTGGAATTTCCAAAAAATCTCAAAATAAΆGTGTTTGGAGCΆTTT

TCTCAAGTAGATGGTTCCGCAAGACGΆGAΆTATGGTGGCTCTGGATTΆGGTTT

AGCTATATCAAAGAAATTGACTGAACTAATGGGTGGCACAATTAGATTTGAAA

GTGAGGAAGGGATTGGCACAACGTTTTATGTTAGCGTCATTATGGACGCAAAA

GAATACTCATCCCCGCCATTTAGTTTAAATAAAAAATGTTTGATTTACAGCCA

GCATTGTCTTACTGCCAAGTCAATTTCAAATATGCTTAATTATTTTGGATCAA

CAGTTAAAGTCACTAATCAGAAGTCTGAGTTTTCAACTTCCGTGCAAGCCAΆC

GACATCATTTTTGTTGATCGCGGAATGGAACCTGATGTTAGTTGCAAAACCAA

AATCATTCCCATCGACCCAAAΆCCTTTCAAΆΆGAAACAAACTCATTAGTATTC

TCAAAGAACAACCAAGTTTGCCCACCAAAGTGTTTGGAAACAACAAATCTAAT

TTATCAAAACAATACCCTCTAAGAATATTATTAGCAGAAGACAATCTTTTGAA

CTATAAAGTATGTTTGAΆGCATTTGGATAAATTGGGGTACAAGGCAGATCATG

CCAAAGATGGAGTAGTAGTTTTGGATAAATGTAAAGAACTACTAGAAAAAGAC

GAAAAATATGΆTGTCATATTGATGGATATTCAAATGCCTCGTAAGGACGGTAT

TACAGCTACAAGGGATTTGAAAACATTGTTTCACACACAAAAAAAGGAAAGTT

GGTTACCCGTGATCGTAGCATTGACAGCTAATGTTGCTGGAGACGACAAAAAG

AGGTGTCTAGAAGAGGGAATGTTTGATTTTATAACCAAACCCATTTTACCAGA

TGAACTTAGACGTATTTTAACAAAAGTAGGGGAAACAGTGAATATGTAA

CHS3; ATGTCTAATTTTAGAGATAGTTCTAGTCCTCGAAGAGGCTATTCAGAATTTGA 78

D13454; TCCTGAATCTGGTGAAGGTTTAGGAAGAAAGAAATCATTAATTAGACCAGAAA

218361 GATCAAGAATGGATGAAAGCCATCCACGATTCCATTATACTCAAGTTGCAAAT CAΆGAATCTAATCATATTAAAGTACAGCCATCTTCAΆCTGGTGTTGATCCTCG

TAAATCAΆATGAATTATCAACATCAAGATCACATTTGAGTAATTACGCTACTC

CACCACATCAAGAGGAAGAAGAAGACGAAGGGATCCCTTTAATGGATATΆCAC

AATGCTTCACCCAATGTTAGCAGTGACCAAAATAATGATCTAAAAGGTGGACG

TGAAGTTTATGGΆTTAAATGATGAAATCAACGATTATGGTΆGTTCACCCAAGA

AAAACCAAGTCATTTCATCTTCAAGACCAATGAACAACGAAAAACCAGCTAAA

CCTAAΆCATGATΆTATATTTCTGGAAAGTTTATTGTTATGCTATTACATTTTG

GGCACCAGCTCCATTATTGAAΆTTATTTGGATTACCAACΆΆAAGΆTCGTCAAT

TCGCTTGGAGAGAAΆAAATAGGGTTGATTTCTTGTATTCTTTACGTTGGGGCA

TTTGTTGCTTATTTGACTTTTGGTTTCACTAAΆΆCTGTTTGTTCGAGTCAAGT

GGTCAGΆACCCΆΆATTAATCATGTCAACGGAGGTTATTTGATTATCAATGGTA

GAGCTTATGATTTGACTTCGTCACAACATCCTAAAGCAGCTGGTATACAAGCA

GGTTCTAATGTTTTATATCCTCCCATGAΆTGCCGGTGGTAAAGACGCATCATT

TCTTTTCCAAAATGTTAATGGTAACTGTAAGGGTTTGATTAAΆCCAAGAGATA

ATTGTTCTATTCCCTACGATGGTGATGAATTGGCTTGGTATATGCCATGTCGT

CTTTTCAACCAΆGATGGTTCAACCAAACCAAATAACACATTTGCTTATTATAA

AGGTTGGGCATGTCATACTAGTGAGACCGCTCGTGATGCCTACTACAΆATTGA

AAGTCAATGGTGATGTTTATTTCACTTGGGATGATGTCAAGAΆTTCTTCAAGA

AACTTGGTAGTGTATTCTGGGAATGTGTTAGATTTGGATTTGATAAATTGGAT

TGAAACCGATGATGTTACTTATCCGGAATTATTTGACAAATTAAGAGATGATG

AAACTTATCGTGGATTGGATATATCTTTGGTTTTGACAAATTCTGAAGAACGA

CAΆGCAGCTAGATGTTTAΆCCGAAATCATCAAAGTTGGTTCTATTGATACAGA

TACTATTGGTTGTATTGCCTCTAAAGTTGTGTTGTATATGTCCTTGGTGTTTA

TTTTATCGGTTGTTGTCGTCAAATTTATTATGGCTTGTTGGTTTΆΆΆTGGGTC

ACTTCAAGAAAACAGGGGGCAACAATGTATGATTCCAAGGCTTGGGCCAAAAG

AAATAGAGAAATTGAAGACTGGGTCGATCATGATCACGGTATTGGTGCTGAAG

TTAAGACAGTGCCTGTGAΆAGCTΆGAGCCAATTATAAAGCAGCTAΆΆACTAAT

AGACAATCTGTTTTCCACAGAGCTCAAAAATTGTCATTGGGACCAAATGCCGA

TTTATCACAATATTATGATAATCCAAATGCTCTTTCCAAGACTTTTAAATATA

CCACTATGTCTACCCAAGCGGCATTGTTAGGACGTAΆCGGATATGGTAAACGT

GGTAATAATGCCAATAAAAGTGTTAGTGGAGGGTTTAATGGTAGACAATCCAA

TCTTTATTTAACTGATCAAGGTTCTTCCACTGATTTATTGAACCGTCCAGTGT

CTTCTTATAATCCATTTGATTCCATGGGTGATGATTCTATTGTCATTAATGGG

TTATCTCCAGATATTATTCACCCAGATGTTGTTCCTCAACCACCAGTCGAATA

CCAACCATTTGGATACCCATTAGCTCATACAATTAATTTGGTCACTTGTTATT

CTGAAGATGAAGAAGGTATTCGTATCACTTTAGATTCTATTGCCACCACCGAT

TACCCTAΆTTCTCATAAATTAATTCTTGTTATTTGTGATGGTATTATTAAAGG

TTCAGGTAATGATGAAACCACTCCTGATATTGTGTTGGATATGATGTCGGACT

TGACTGTGCCAAGAGATGAAGTTGAAGCTTATTCCTATGTTGCTGTTGCCCAA

GGTAGTAAACGTCATAATATGGCCAAAGTTTATGCTGGGTTTTATAAATATAA

CGATGAAACTGTGCCACCAGAAAAGCAΆCAACGTATTCCGATGATTACTATTG

TCAAATGTGGTACCCCTGAΆGAΆGCCAGTGCACCAΆAACCAGGTAATAGAGGT

AAGCGTGATTCACAAATCATTTTAATGTCATTTTTACAAAAAGTTGTTTTCGA

TGAAAGAATGACTAGTTTAGAATATGAAATGTTACAAAGTATTTGGAGAATCA

CGGGATTAATGGCAGΆATTCTATGAGATTGTATTGATGGTGGΆTGCTGATACA

AΆAGTTTTCCCTGATTCTTTAACTCATATGGTTGCTGAAATGGTGAAAGATCC

AACTATTATGGGATTATGTGGAGAAACAAAAATTTCTAACAAGGCGCAAACCT

GGGTTACAGCAATCCAAGTTTTTGAATATTATATTTCACATCATCAAGCCAΆG

GCGTTTGAATCGATTTTCGGTGGGGTTACTTGTTTACCTGGTTGTTTCTGTAT

GTATAGAATCAAGGCACCAAAGGGGTCCGATGGATATTGGGTGCCTATTTTGG

CAAATCCTGATATCGTGGAAAGATATTCTGATAATGTGGTTGATACTTTACAT

CGTAAGAATTTGTTATTATTGGGTGAAGATCGTTATCTTTCGTCATTGATGTT

GAGAACTTTCCCTACGAGAAAACAAGTGTTTGTTCCTAAAGCTGCTTGTAAGA

CTGTTGTCCCCGATAΆATTTAAΆGTGTTATTATCGCAΆCGTCGTCGTTGGATC

AΆTTCTΆCTGTGCACAATTTGTTTGAΆTTAGTTTTAGTTAΆAGATTTGTGTGG

TACTTTCTGTTTTTCTATGCAΆTTTGTTATTTTCATTGAATTGATTGGTACTT TGGTGTTACCAGCAGCCATTACATTTACTATTTATGTGATTATTGTTGCTATT

GTATCTAAACCAACTCCAGTTATGTCCTTGGTTTTΆTTAGCAGTTATTTTCGG

GTTACCTGGTTGTTTAATTGTCATTACTGTGTCATCCTTATCTTATCTTGTTT

ATTTTGTTATTTATCTTTTCGCATTACCAATTTGGAATTTTGTGTTΆCCAΆGT TATGCCTATTGGAAATTTGATGATTTCAGTTGGGGTGAAACAAGAΆCAGTTGC TGGTGGTGATAAAGGAGATCATAGTGCTGTTGAAGGTAAATTTGATTCATCAA AGATTGCCATGAAAAGATGGAGAGAATGGGAAΆGAGAΆCGTAGAAGTACTGAA AATAGAAAACΆGCAACAACAGCAACAATTGΆCAAACAATTCTAGTAΆTAATTT GGCTGTTCCTGGTGCTGCTTGGGATCCATCTAATΆCTGGAGGAAATTTGATTG ATGATTTAAGTCAΆGGATCTTCTTCAGGGTCCAGTTGA

CLA4; ATGACAAGTATTTATACATCAGATTTGAAAAACCATAGACGTGCGCCACCTCC 79

U87996; ACCAAATGGGGCAGCTGGCTCTGGCTCAGGTTCTGGCTCAGGTTCTGGTTCTG

2351701 GTTCTGGCAGTTTGGCTAΆTATTGTTACCAGTTCTAATAGTCTTGGCGTAACA

GCAAATCAAACCAAACCTATTCAΆTTAAATATAAATTCTAGCAAACGTCAATC

AGGTTGGGTTCATGTTAAAGATGATGGTATTTTCΆCATCATTTAGATGGAΆCΆ

AACGGTTTATGGTTATTAATGATAAAACTTTAAACTTTTATAAACAAGAACCA

TATTCTAGTGATGGTAΆTTCCAATTCTAATΆCCCCTGATTTATCATTCCCACT

ATATTTAATTAATAATATTAATTTGAAACCAAACTCCGGGTATAGCAΆAACTT

CΆCAATCATTTGΆAATTGTTCCCAAAAACAATAATAΆATCAATTTTGATTTCT

GTTAAAACCAATAATGATTATTTGGATTGGCTAGATGCATTCACCACAAAATG

TCCTTTAGTACAAATTGGTGAAAATAATAGTGGTGTATCAAGTAGTCACCCTC

ATTTACAAATTCAACATTTAACCAATGGTTCCTTGAACGGCAACTCATCTTCA

TCACCAACATCTGGATTATTΆTCTTCTTCΆGTGCTAACTGGAGGTAΆTTCTGG

CGTTTCTGGTCCTATTAATTTCACTCATAAAGTACACGTGGGATTTGΆTCCTG

CCAGTGGTAATTTTACTGGATTACCAGACACTTGGAAAAGTTTATTACAACAT

TCGAAAATCACTAATGAGGATTGGAAAAAAGATCCTGTTGCTGTTATTGAAGT

TTTAGAATTTTATTCCGATATAAATGGΆGGTAΆTTCAGCTGCTGGAACTCCAA

TTGGATCACCCATGATCAATTCCAAAACCAACAATAATAATAATGACCCTAAC

AATTACTCATCΆACCAAAAACAATGTCCAAGAGGCAAATTTACAAGAATGGGT

AAAACCTCCAGCΆAAATCTACTGTCTCACAΆTTCAAACCTAGTCGAGCTGCΆC

CAAAACCACCAACTCCATATCATTTGACACAACTAAATGGCTCTTCCCACCAA

CATACATCATCATCAGGCTCATTACCTAGTTCTGGTAATAATAATAATAATAA

CAGCACTAACAATAATAATACTAAAAACGTTTCACCATTGAATAATTTGATGA

ATAAATCTGAACTTATTCCTGCTAGAAGAGCTCCACCACCTCCAACAAGTGGC

ACATCTTCAGATACATATTCTAATAAGAATCATCAAGATAGΆTCTGGATATGA

ACAACAACGTCAACAACGTACTGACTCATCACAACAACAACAACAACAAAAGC

AACATCAATATCAACAGAAATCCCAACAACAACAACAACAACCACAΆCAΆCCA

TTATCTCTGCATCAAGGTGGGACTTCGCATATTCCGAAACAAGTACCTCCTAC

ATTACCATCATCTGGACCACCCACTCAGGCTGCTTCAGGAAAATCAATGCCAT

CTAAAATTCATCCTGATCTTAAGATTCAACAAGGCACAAATAATTATATTAAG

AGTAGCGGTACTGATGCTAATCAAGTCGATGGTGATGCTAAACAATTTATTAA

ACCATTTAATTTACAACTGAΆAAAGAGTCAGCAACAATTGGCATCAAAACAΆC

CGTCACCACCTTCATCTCAACAACAGCAACAAAAACCTATGACATCACATGGA

TTAATGGGTACATCACATTCAGTTACTAAACCATTGAATCCAGTCAATGATCC

AATCAAACCATTAAATTTGAAATCATCTAAATCCAAAGAAGCATTAAATGAAA

CTCTGGGGGTGCTGAAAACACCATCACCTACAGATAAATCAAATAAACCAACT

GCACCTGCTAGTGGTCCTGCAGTGACCAAAACAGCTAAACAACTCAAGAAGGA

ACGAGAAAGATTGAATGATTTACAAATCATTGCTAAATTGAAAACAGTGGTTA

ATAATCAAGATCCTAAACCATTATTTAGAATTGTTGAAAAAGCTGGTCAAGGT

GCTAGTGGGAATGTTTATTTGGCGGAAATGATCAAAGATAATAATCGAAAGAT

TGCGATTAAACAAATGGATCTTGATGCTCAACCCCGTAAΆGAGTTAATAΆTAA

ATGAAATCTTGGTTATGAAAGATAGTCAACATAAAAATATTGTTAATTTTTTG

GATTCTTATTTAATTGGTGATAATGAATTATGGGTAATTATGGAATATATGCA

AGGTGGTTCATTAACGGAAATCATTGAAΆATAATGATTTTAAATTGAATGAAA

AACAAATTGCCACTATATGTTTTGAAACCTTAAAGGGGTTACAACATTTACAT

AAAAAACATATTATTCATCGTGATATTAAATCCGATAΆTGTTTTATTAGATGC ATATGGTAATGTTAAAATC_ACTGATTTTGG_ATTTTGTGCTAAATTAACTGATC AAAGAAATAAΆCGTGCCACA_ATG_GTGGGG_ACACCATATTGGΆTGGCACCTGAA GTGGTTAAACAAAAGGAATA_TG_ATGAAAAAGTTGATGTTTGGTCATTGGGGAT TATGACTATTGAAATGATTGAAGG_AGΆACCACCTTATTTGAATGAAGAACCAT TAAAAGCTTTATATCTTATAGCT_ACTAATGGTACACCAAAΆTTGAΆAAAACCC GAATTATTATCGAATTCAATTAAAAΆΆTTCTTATCAATTTGTCTTTGTGTTGA TGTTAGATATCGTGCTAGTACTGA_TGAATTATTAGAACATTCATTTATTCAAC ATAAATCAGGGAAAATTGAΆGAA_TTGGCACCATTATTAGAATGGAAAΆAACAA CAACAAAAGCATCAACAGCATAA_ACAAGAAΆCACTGGATACAGGATTTGCATA

G

CRKl; ATGTCTGTTATTGCTGGCCATCATGTGCCGAGGTCAAATGATCAAAGGCAATA 80 U92261; CGATACACCGAGCGTACCAATAAATATCGCTCCGGATTCAGAAGGTCATATTC

4584845 ATGAAATGTCTCGATTGAAΆGATTATGAAGTGATAGAGAΆACTAGGTCAAGGA

ACATTTGGAGTTGTTCAAAAAGCAAAATCCAAAAAAGATGGCCTGTTAGTTGC

AATTAAACAATTGATTAACCATTCTGCAAAGGAAGGATTCCCAATCACTGCCA

TGCGAGAAATTACCATTTTGAAACAATTAAATCATAAAAATATTTTAACCATA

CAGGATATGATATTTGAAGAΆCCCAAAATGAGCAATCGAΆCAGATATTATTAC

TATGAGGGGTTCTTTTTATACTGTAACCCCATACATGTCGAGTGATCTTGTTG

GATTACTAGAGAACCCGAAAATTAAACTTGAACTTGGACAAATAAAΆTGTATC

ATGCAACAATTATTGAAAGGTATTCAATATGTACACAACCAAAAGTTTTTGCA

TCGAGACATTAAAGCAGCTAACATTTTAATCGGTCAAGATGGTGTTTTGAAAA

TTGCAGATTTCGGTTTAGCAAGAΆTATATCATGGTAACGTACCGAGATTGGGG

ATGGGTCCTGGTGGAGGAGAAAAAGCATATACTGGATTGGTTGTAACTAGATG

GTATCGACCACCAGAAATATTACTAGGAGAAAGAAAATATACTΆCTGCAGTTG

ATCAAAGGGGGATTGGATGTGTATTTGCCGAATTATTCACTGGGAAACCAATT

TTGGTAGGGAAATCAGATTCTCATCAAGCACAAATTGTATTTGAGTTGGTTGG

ATCACCTTTGACATGGACTGATGCTGCAAAACTACCCAATAAAAATGAGTATA

GTTGTGGCTTGGCTTGTAAACGAAGTCTTGAAGCAAAGTTTGCTAGTATCATG

CCTACTGAAGCTATTGACTTGTTAAGTGGATTGTTAACATTAGATCCTTTCAA

GAGACTTAATGCCTTGGATGCTTTGAATCACAAGTTTTTCAGTACTGATCCAT

TACCATTATTACCAACCCAAATGCCTAAATTTGAAGAAAGTCACGAAATTGAT

AAAGAACGATTTAAAAAATTGAAAGATAAAGAACAAGCTGTTAGTGAGTTGAA

GCCTCCAACTGAAATACGTTACGACAATCATTCGGAATCGAGGTATAATGCAG

ACCATTCTACTTTTGGTGGTGGTGGTGTTGGCGGTAAAGAAACAAGTTTTAGT

TCCGGGAAATCAGACTATATCGACCATTATGAACCAAGAGCACGTΆGGGACCA

TTATGAACCGAGAATACGAAATGATAATAAAGATTCCAACGATGTTAGAGGAG

AGTTTGAACTGGCTACAAGACAAGAACAAAGACGGAGGGATATTCAAAATAGG

CTTGATGCAGGTGGAATGGATACTTACATTCCAAAAACTACCACAGGAAAACT

TCGGGAACACAGTGGTACAGAGTCTTTGCTGCAAAAGTATGATAACTATCAAC

CAATAAACGTCTCCAGAGGATCAAAATCTCCATCTCCGTCAAAACTCCTGTCT

ATTTCACAATCAAAGGCAGATCTCATTAGTAAACCATCGGCTCCAAAGGTTGC

ATCTAGAGAΆAGTTCGCTCGΆGAGGAAGCAAGTTTCAAATGGTΆTCCGTACTA

CTACCGATGTGGAACCACCAAGAGCAAGGGCTCGTCGACCAACTGACATGTTT

GGAAGACCGTTGACTTCAAATAGTACTCAGGCACAACCAACAAGAAACAAATC

GGTGGAGCGACCAAAAGATCTTGAGAAACCTACAAATGGTGTGACTGAGGATA

GGAATAAGAAACCAGTTTTGGAAGAGAAGAAAGAAGTTGTCAAΆCCAAΆTTTG

GCAATTCCAAAΆATCAAAAAGAGCAGTTCTCTAGTGCTGTTGCTGTCTAGATC

GTCCACAACACCAGTTATTTCTAATCCGTCGAAGGTCACAAAAAGAGCAGCAA

GTAGTGTGACACCACCAGTGCTACCAAAGAAACCAAAAATATCCAAAACTAGT

TCAGAAAGTGAAGTAAGTGATTTGGAAGAAGACAGTGATTTTACAGGTGAGAA

TGCAACTGTATTTGAAAGGTTTATGGCACTTGAACAATTACAAAAATCGCCAG

TTTATAAAAGAATTATAAATGAGAAAATGAGGTTTGAAAAGTTATCGGGAGGA

CACAAATCTATGTAA

CYRl/ ATGAGTTTTTTAAGGAGAGATAAATCTAAAGCCAACTTTAGAGATGGTTCAGC 81

CDC35; TACTGGATTAGAGGAACCAGTTTCCCCCACCACTCATTTTTCACCCAATGTTC

AJ250877; CACCTCCACTCGATGGCAATCATGGGGATCATTATCATGATCCAGACTCCCCA AGATCTTCTGTTGTGTCATTACCGCAACTAATTCATAACTCAGCTACCCACCA

TTTGAAAGAAAATTATCGCGGGTTCCATGCCAACAAACGACCAAAAGGTATTG

CCAATGTTCCTCCATTGGCTCAACCTATAAAGCCACGATTTAΆAAAGAAGAGC

AATTCATTATTGAATAAGCTAATATATTCCΆCAAAGAAAGAAGACGATGAAGC

AGCCACAAGTGGGAAAGAGTCTCGATCGAGCTCTATCATATCGGATGAAAAAC

GCAAAAGTGCTAGCCTGGCATCGTCTGGCAGTTCAAGACAAAΆGTTTAGATTC

TCTTCATTTGATAGCAATTTGTCTACATCCTCTAGTTCTCCTCCTAAAGATAA

AAΆAGTACTGGTTTCCGACACCGTGTCGGATTCATCAACGGTTACTGCATCCA

TGTCAAΆTATGCCAACGATATCGATTGΆTCTTAATCTCGACGAAATGCACGAC

ATTATCAAGTCACCTGAAACCCCAACCCCGACTGCTGGCTTACCAACCCAGAA

AGCAGAGAAAAAGGCTTCACCAACAGCCATCAAΆAACTGGCAGGCCCCTGAAA

GTTGGGATGTGAAGGCTCCTATTAAAAAGGAAGAACCTCATGCACCTAAGATT

GAAGAAGTTGCAGAGAATGATGTAGCAATAGATAATGTTTTGGAAAAGAAACG

ATTGCCGGTACTATATGGTACTCΆCCAAGTGCCGCATGTTACAAATTCGAAAG

ACATAAAGTCAAGTCACATTATTCGAGTATTCAAAGAAGATAACACTTTCACG

ACAATCTTATGTCCCTTGGAAACAACCACCAGTGAGCTTTTAGCTATTGTGCA

AAAGAAATTCTTTCTTGAGTCAACAACCAATTTCCAACTATCGGTGTGTATTG

GGAACTGTGTTAΆGGTATTGGAAGATTTTGAAAAGCCTCTCAΆGATTCAAATG

GGGTTGCTTTTACTCAGTGGTTATACAGAAGAGGATAAGTTGAGAATGTTAGG

AAGAGAAGACTTGTCATTTGTATGCAAATTTGTTGTTGAAAACATATTTTTGA

GGAGTTTGACTCATGATGAAGAAGTTTTATTGTCACGGAATTACGTCGATGTC

AATATATCTTCACTAAATTTGAAAAATGTCCCTATTATATTCCATCAACATAC

TTATGAGATTGAAAAATTAAATGTGGCCAATAATCCCTCCATATACTTGCCAT

TGGATTTCATTCAGGGATGTACTAGTTTGGCGTATGTGGACTTTTCCCACAAT

GGGTGTTCTAAATTCCCCAATAATTTATTAGAAGCACCCCAATTGACTCATTT

GAACTTGGAAATGAACTTTTTGGATGAAATACCCCAAAGAATAAGTTGTTTGT

CAAATTTΆACTAACTTGAAATTGAGTTCGAΆTCAACTTTATTCGCTTCCACAT

TCATTTAGTACCTTAACTAATTTGAAACAGCTTGATTTGTCATCAAATTATTT

TGATAGCTACCCGGAAGCAGTCAACAAATTGACCAATTTAGTGGAATTGAATT

TTTCATACAATGATTTATCGATAATTCCTGAATCTATTGCGΆATTTGATTAAC

TTGCAAAAATTAAATTTATGTACTAATAAGTTGTCAGGGACATTACCTGGTTA

TTTGTCCCAATTAAAAGCGTTAAAGCGTTTGGATATCCGATATAATTATATTT

CCAACGTTGACGTATTGGGAATAATACCTAATTTGGAGGTTGCCTATGCATCC

AAAAATGCAATCTCAACATTTAGTGATCAAATGAAGTGCTTGAGACTCTTACA

TTTTGATAGGAATCCAATAACCGAACTTAAGTTTAATACTCAGATGCAAATGT

TGTCCGTTTTAGATTTGTCAAGAGCAAAAATTACGGCATTCCCGGCAGAATTT

GTTGAAAAGGTTCCAAATATTGAAAAATTAGTGCTTGACAAAAATCATTTAGT

GTCTCTCCCTAATGAACTTTGTCAATTGTCAAAΆTTAGTATCATTATCTGTAC

ATGCCAATAATTTGCAGTCTTTACCAGCAAACATTGGAGATTTAAGATTTTTG

AAATATTTGGATTTGCACAGTAACAATTTGAAΆTCΆTTGCCTGATCAAATTTG

GGATCTTTGTCATTTGACACTGTTAAATGTTGCATCCAATAACTTGACTTCAT

TCCCCAAGGCTCCTTATTCTGTCGTGAAAAGGTTATCTTCGTCTCTTGTTGAT

GTACATCTCGAΆTCTTCGCAAΆCTTTATCTTTAGCTGACAGTTTGTTGATTTT

AATATTGTCTGATAATCGATTAAGTGACGATTGCTTTGATGAGATTTCATTTT

TGATAGCCTTAAAGTCGTTGAATGTGTCATACAATGATTTAATAGAGATTCCA

CAGGGGACATTAAGTCGTTTGACTAGGCTCAATGAGTTGTACTTGTCAGGAAA

TGAATTGACAACTTTACCAGCTGATGACTTGGAAGTGCTAAAGTCATTAAAAT

TGTTATACATGAATAATAACAAACTTGTTTCACTCCCAGCAGAGTTGAGCCGA

ATCGCCAATTTGCAACATTTGGACGTTAGTTCTAATCAATTGAAATATAATAT

TTCCAATTGGCCATACGATTGGAGTTGGCACTGGAATAAAAATTTAAAATATT

TGAATTTTTCCGGTAATAAACGGTTTGAAATAAAACAAAGTCATATTAAGAAT

CCCGAΆACAGGAGAGGATTTCGATAGTTTATTGGTATTGAAGCAATTGAGAGT

GTTGGGATTGATCGACGTTACGTTGACGACAACAAACGTGCCAGAACAAGCTG

TTGACTTGAGATTGAGAACTACTGCTTCTGAATTTGATAATTTTGGGTATGGG

GTCAGTGATTCTTTAGGTATGAGGGACCATGTTTCAGCACGTGATTTATTTGT

CCAAAAGTTTAGAGGTAAAGAAAACGAGATGTTGCTTTGTGCATTTGATGGTA AGCATGGGGCAΆCTAATCAAGGTCACAGGATCTCCTTGGTTGCGAΆAAACATG

TTTGTGAGAAATTTCACAAAAGAATTGGATGAAATAAAGAGTGATGATGAAAT

AGAAAΆTGCCCTTAGAAAAGCTTTTTTGAATTTCAATAΆAGAAATCAΆTGGTA

TTTTGACCGCTAAAAAGAACAAGTCATTTACACCTGTGCCTAACATGTCAAAA

GAAGCTCTTGAATTGΆΆTTTGGTAGACGATGGTAACGCTGGTTGTACCGTGTC

TGTGATTTATATTAAAGATAAGAAACTTTATTCTGCAAACATTGGTGΆCATTG

AGGCGCTACTTTGCAGGAACAATGGTGATCAATTTTTACTTACTGAAAAACAT

GATCCAACCAΆTCGTGAAGAGTTTGAAAGAATTAGAGCCTCTGGCGGATATGT

TTCAGGTGGGGGAGAGTTAGATGGGCAATTATCAGTGTCACGAGGGGTAGGAT

TTTTCAACTTTTTGCCTCATACACATTGTGGGCCTACTATTCGCCGGTTTAAA

ATAACTAΆTGACGATGATATGATTATTTTGGGAAGTAAACAGTTGTGGGATTT

CΆTCTCTTATGAATCAGCTGTTGACATTATCCGTAΆAGATAAGAATGATCCTA

TGGTGGCCGCACAAAAGTTGCGAGATTTTGCTATATGTTATGGTGCAACCGAT

AAΆATTTGCGTCATTGTCTTAACTTTTGGTAATAGGCAGAAACAAGCTGCCAA

TATGTATTCAAATTATGGTGTTGATAGAAGACGTCGAGATAAGCAACAAGTTG

TTGGTGGAGACTCTAATCTCCGTAAATTAGAACAAGAGATTGAGCCACCAATA

GGACCATTAGCTTTGGTTTTCACTGATATCAAAΆACTCAACTTTATTATGGGA

TTCGTACCCGGCACCTATGAGATCAGCAATCAAAATTCATAΆTACAATAATGC

GTCGACAATTGCGAATTACTGGTGGATATGAAGTGAAGACTGAΆGGTGATGCG

TTCATGGTTGCCTTCCCTTCGCCAACCGCGGCTTTGTTGTGGTGTTTCCAΆGT

GCAACAAAACTTGGTGACTGCAGACTGGCCATCAGAAATACTTGAAACTGATC

AGTGTTGTGTAGTATCGGATTCAGAAAΆCAATACCATTTTCAGGGGGTTGTCG

GTTCGTATGGGTATACATTGGGGTTCTCCTGTATGTGAACCAGATGTTATAAC

TGGCAGAATGGATTATTTTGGACCAATGGTCAATAGAGCGTCGCGTATCAGTG

CTATTGCTGATGGTGGACAAATTGCTGTCAGTTCTGATTTCTTGGATGTGTTG

AATAGTTTAACTGTTAAACATAATAATATCAAAAACAATGTTGAGTCTTTGAT

TGATGCCTATCAGGGCAATGAAAATGCCGGAATGACAATTGAACGAGAATTGA

ATGCATTGGAGGATCTTGGGTGTAACTATTTTAAAΆTTGGTGAGCGTAAATTG

AAGGGGTTGGAAACACCAGAΆCCTATCACTTTGGTGTTTACCAATAGATTGAA

ATTGAGATATGATATATTTCAΆAAGAGACTTGATGCAAATCATAGTACTCGΆG

TGGCTGGAACATTACCAGTGGAGATCATATATGGCTTAAGAACAGTATCGTTA

AGGTTGGAGAATCTCTGTTCTTCGATCAATAATGGTGGTAATTATTGCAGTGA

AGGATTTGAATCTTCΆTCAGGGGTTATTTCACAAAAGATGAATTCATCGTTCA

AAGATCTGGATTTGATCTCATTGCTCAATCACGTTACAACTAGAATTGAAAGT

TGTACCACAΆCATTGTTTTTGCGTCAACAATTAΆGTCAAATTAAΆGGAAATGG

CGGGTTGATAGAGACTAACAATTCTCCATCATTGGATGTTATTATGGATGAAG

TAGCAGACATCATGAAAACAGTTAATGAACTTAAATAGA

EFGl; ATGTCAACGTATTCTATACCCTATTACAATCAAATGAACGGAAATTACAATAA 82

Z32687; CGGTATGCCCCAGCAAΆCAACTGCAGCCAATCAACAGGCTTTTCCTCAGCAAC

6468469 AACAACCAACAACAACAGGCAATGCTAGCCAΆCAGCAΆCAGCAAGCAGCTGCT ACGGCAGCTGCAGTCCAACAGCCTTATAACTACATGTTCTATCAACAACAAGG ACAACCAGGTCAΆCAGACTGGACAGACAGCAGGACAACAΆCAACAACAGCAGC AGCAGCAGCAACAATATGATTACAATACCTACAACAGATATCAGTATCCTGCC GCAACATCTCAAGGAAACTATTACCAGCAAACAΆTTCCTAATCAATTGTCACA GCCACAACCTCAGCATTACAATGGATCTAATCGTAATTACACAAGTGCTCCTA GTGGTGCCCCCATACCTTCCAATTCTACCAGTGGACCTTCACAACAGCCACCA CTACCAGGTCAACAΆGCAGTACCTATCCCACCACATGTATCGACAATGCAACA ACCAACTCCTGTTCAGGATACGTTGAACGCCTCGAGCACTTCCACTGTGGGGC AATTCCAACCACCAGGAATCAGACCACGAGTAACAACTACCATGTGGGAAGAT GAAAAAACTTTGTGCTATCAAGTTGATGCCAATAATGTGTCGGTTGTCAGAAG AGCAGATAATΆATATGATCAACGGAACCAAΆTTGCTCAATGTGGCCCAAATGA CACGTGGTAGAAGAGATGGGATTTTGAAATCAGAAAAGGTGAGACACGTTGTG AAAATCGGATCAATGCATTTGAΆAGGAGTCTGGATTCCATTTGAAAGAGCATT GGCCATGGCTCAΆCGTGAΆCAAATTGTGGATATGTTGTATCCTTTGTTTGTCA GΆGATATTAAACGAGTGATTCAAACCGGAGTAACTCCTAATGCAGCTGCTGCA ACGGCCGCCGCCGCTGCCACTGCCACTTCTGCTTCGGCTCCTCCACCTCCACC

TCTCCTTGTCATCAGGAGCAGGCTCCGGTGCAGGCGCCGCAAATAGTGGTGGT

GCTGTTGTTGATAGTGCTGCCTTAGATGCTTTAACAGCTGΆAAACAΆGAAATT

AGCCAAACAGCAATTAGAAGTTTTAGCAΆGATACTTGCAAΆGTCGACTTAAAC

AAGGGAGCCTTAAATCTTTTATCAAGGAAAAGGAΆGCTTCTGCTGTTTTACAA

AAAGAGTTAGATTTGTGGGAAGCAGAΆCACGGAGAATTCTATGCTAAGGGTAT

CCAACCAACTTTCTCCGCATTAAAGTCTAGAACTTATGACTCCTΆTTGGAATT

GGGCCCGTCAAGACGTTTTATCAATGTATTTCGACATTATTTTTGGCAAGTTA

ACTTCTGTTGATAGAGAAACCATCAACCAATGTATTCAAATCATGAACAGAGC

CAATCCAACTTTAATCAΆGTTTATGCAΆTATCATATCGACCATTGTCCAGAAT

ATAAAGGTGAAACTTATAAATTGGCCAAGAGATTGGGTCAACAATTGATTGAC

AACTGTAAACAAGTTTTGACTGAΆGATCCAGTTTACAAΆGATGTTTCCAGAAT

TACTGGTCCAAAGACTAAAGTCAGTGCTAAGGGTAACATTGAATATGAGGAAA

CTCAAAAGGATTCAGTTAGAAAATTTGAACAΆTATGTGTATGAAΆTGGCCCAA

GGTGGTGCTATGACCAAAGTTAGTCAACCAACTATTCAAGAAGATTTAGCTAG

AGTTTACAAGGCTATTTCCAAACAAGCTTCCAAAGATAGCAAATTGGAATTGC

AAAGAGTTTACGAAGATTTATTGAAGGTGGTTGAAAGTTCCAAGGAAATCGAA

ACCGAACAATTGACTAAAGΆTATTTTACΆAGCTGCTACAGTTCCAACAACCCC

AACAGAGGAAGTAGACGATCCTTGTACTCCTTCTTCGGATGATGAAATTGCTT

CTTTACCAGATAΆGACTTCTATCATTCAACCTGTCTCGTCTACTATTCCATCT

CAAACTATTCCATTTTTGCACATTCAGAAAAAGACCAAAGACGGTTGGGAATA

CAATAAGAAATTATCTTCTCTTTACTTGGATGGATTGGAATCAGCTGCCATTA

ATGGTTTAACTTTCAAAGACAAGTATGTCTTAGTTACTGGTGCTGGTGCTGGC

TCTATTGGTGCCGAAATTTTGCAΆGGTTTAΆTCΆGTGGTGGTGCCAAAGTTAT

TGTCACAACCTCTAGATTTTCCAAGAAAGTTACCGAGTATTATCAAAACATGT ,

ATGCCAGATATGGTGCTGCTGGGTCTACTTTAATTGTTGTTCCGTTCAACCAA

GGTTCTAAACAAGATGTTGATGCATTGGTTCAATACATTTATGATGAGCCAAA

GAAAGGTGGTTTGGGTTGGGATTTGGATGCAATCATTCCATTTGCTGCTATTC

CAGAAAATGGTAATGGTCTCGACAACATTGATTCTAAATCTGAATTTGCCCAC

AGΆATCATGTTGΆCCAACCTTTTAAGATTGTTAGGTGCTGTTAAΆTCCAAAAA

GCCCACTGACACTAGACCTGCTCAATGTATTTTGCCATTATCTCCAAATCACG

GAACTTTTGGTTTTGACGGGTTGTACTCTGAATCTAAAATCTCATTGGAAACC

TTATTCAACAGATGGTATTCTGAAGATTGGGGATCCAAGTTGACTGTTTGTGG

TGCCGTAATTGGGTGGACTAGAGGTACAGGTTTGATGAGTGCCAΆTAACATTA

TTGCTGAAGGTATTGAAAAATTGGGTGTCAGAACTTTCTCCCAAΆAGGAAATG

GCTTTCAATATTTTAGGTTTATTGACACCAGAAΆTTGTACAATTATGTCAAGA

AGAACCAGTTATGGCTGACTTGAATGGTGGTTTGCAΆTTCATTGACAACTTGA

AGGATTTCACATCTAAATTAAGAACCGACTTGTTGGAAACTGCAGACATTAGA

AGAGCTGTTTCTATTGAATCAGCTATCGAGCAAAAAGTTGTCAATGGTGACAA

TGTCGATGCAAACTACTCAΆΆGGTTATGGTTGAACCTAGAGCCAACATGAAAT

TTGATTTCCCAACTTTGAAATCTTATGATGAAΆTCAAACAAATTGCTCCAGAA

TTGGAAGGTATGTTGGATTTGGAAAATGTTGTCGTTGTGACAGGTTTTGCTGA

AGTTGGTCCATGGGGTAACTCTAGAACCAGATGGGAΆATGGAAGCTTATGGTG

AGTTCTCATTGGAAGGTGCCATTGAAATGGCTTGGATTATGGGTTTCATCAAG

TATCATAATGGTAATTTGCAAGGGAAΆCCATACTCTGGATGGGTTGATGCCAA

GACTCAAACTCCAATTGACGAAAAGGATATCAAATCCAΆATATGAAGAAGAAA

TTTTAGAACATTCCGGTATTAGATTGATTGAGCCAGAATTGTTCAATGGCTAT

GATCCAAAGAAAAAACAAATGATTCAAGAAATTGTTGTTCAACACGATTTAGA

ACCATTTGAATGTTCTAAAGAAACAGCTGAGCAATACAAACACGAACACGGAG

AAAAΆTGTGAAΆTTTTTGAAATTGAAGAAAGTGGTGAATACACAGTTAGAATC

TTGAAAGGTGCAACATTGTACGTTCCGAAAGCTTTGAGATTTGATAGATTAGT

TGCTGGTCAAΆTTCCAACTGGTTGGGACGCTCGTACCTATGGTATCCCAGAAG

ΆCACTATTAGTCAAGTTGATCCAATCACTTTGTACGTGTTGGTTGCCACTGTT

GAAGCCTTGTTGTCTGCTGGTATTACTGATCCATATGAATTCTACAAATACGT

TCATGTGTCTGAAGTTGGTAACTGTTCTGGTTCCGGTATGGGAGGTGTCTCTG

CTTTGAGAGGAATGTTCAAAGATAGATATGCTGACAAACCAGTTCAAAATGAC

ATTTTGCAAGAATCATTTATCAACACTATGTCTGCTTGGGTCAATATGTTGTT GTTGTCTTCCTCTGGTCCAATCAAGACACCAGTCGGTGCTTGTGCCACTGCTG

TTGAATCGGTTGACATTGGTATTGAAACAATTTTGTCTGGTAAAGCTAAAGTA

GTTTTGGTAGGTGGTTACGATGACTTCCAAGAAGAAGGGTCTTATGAATTCGC

CAATATGAATGCTACTTCTAATTCTATTGAAGAGTTCAAACACGGAAGAACAC

CAAΆGGAAATGTCAAGACCAACTACTACTACCAGAAATGGTTTCATGGAAGCT

CAAGGTTCTGGTATTCAAGTTATCATGACTGCTGATTTGGCTCTCAAGATGGG

TGTTCCAATCCACGCTGTATTGGCCATGACTGCTACTGCCACTGATAAGATTG

GTAGATCTGTTCCAGCACCAGGTAAAGGTATTTTGACCACTGCCAGAGAACAT

CATGGCAACTTGAAGTACCCATCTCCACTTTTGAACATCAAGTACAGGAAGAG

ACAATTGAACAAAAGATTGGAACAAATCAAATCTTGGGAΆGAAACAGΆΆCTTT

CTTACTTGCAAGAAGAAGCCGAGTTGGCCAAAGAAGAATTTGGTGACGAATTT

TCTΆTGCATGAGTTCTTGAAΆGΆGAGAACTGAAGAΆGTGTACCGTGAATCAAA

GAGACAAGTTTCTGATGCTAAGAAΆCAATGGGGTAATTCATTCTACAAGTCTG

ATCCAAGAATTGCTCCATTGAGAGGAGCΆTTGGCTGCCTTCAACTTΆACCATC

GATGATATTGGTGTTGCATCCTTCCATGGTACTTCCACCGTTGCTAACGATAA

GAATGAATCTGCCACAATCAACAATATGATGAAΆCACTTGGGTAGATCCGAAG

GTAACCCAGTATTTGGTGTTTTCCAAAAATACTTGACAGGTCATCCAAAAGGT

GCΆGCTGGTGCTTGGATGTTGAATGGTGCCATTCAAATTCTTGAGTCTGGTCT

TGTTCCAGGTAACAGAAATGCGGΆTAATGTTGATAΆGCTTTTAGAACAATACG

AATATGTATTGTACCCATCAAGATCAATTCAAACCGATGGTΆTTAAAGCCGTT

TCTGTTACATCATTTGGTTTCGGTCΆAAAAGGTGCACAAGCCGTTGTTGTTCA

TCCAGATTACTTATTTGCTGTTTTGGATAGATCCACTTATGAAGAATATGCTA

CTAAGGTCTCTGCTAGAAATAAAAAGACCTACCGTTACATGCACAATGCAATC

ACCAGAAACACTATGTTTGTTGCCAΆAGACAΆAGCTCCATATAGTGACGAATT

GGAACAACCΆGTTTACTTGGATCCATTGGCTCGTGTTGAAGAAAACAAGAAAA

AGTTGGTATTCAGTGACAAAACAATTCAATCGAACCAATCTTATGTTGGAGAA

GTTGCTCAAAAAACTGCTAAGGCATTGTCTACTTTAAACAAATCATCAAAGGG

AGTTGGTGTAGATGTTGAATTGTTGTCAGCAATCAATATCGACAATGAAACCT

TTATTGAAAGAAACTTTACTGGTAATGAAGTTGAATACTGTTTGAATACTGCT

CACCCACAAGCTTCATTCACTGGAACTTGGTCAGCAAAGGAAGCTGTTTTCAA

AGCCTTGGGTGTTGAATCAAAΆGGTGCTGGΆGCAAGCTTGATTGATATTGAAA

TCACTCGTGACGTTAATGGTGCTCCTAAAGTAATTTTGCATGGTGAGGCCAAA

AAAGCTGCTGCTAAAGCTGGTGTTAAAAATGTCAATATTTCAATTTCTCATGA

TGATTTCCAAGCTACTGCTGTTGCTTTΆΆGTGAATTTTAΆ

HOGl; ATGTCTGCAGATGGAGAATTTACAAGAACCCAGATATTTGGGACTGTTTTTGA 85

X90586; AATCACCΆATAGATACACTGΆGCTAAATCCCGTGGGAATGGGAGCATTTGGTT

1616582 TGGTGTGCTCΆGCCGTTGATAGATTAACTGGTCAAAATGTTGCAGTGAAAΆAA

GTCATGAAACCTTTTCTGACCTCAGTATTGGCAAAAAGAACCTACAGAGAATT

AAAGTTATTGAAACATTTGAΆACATGΆGAATTTGATTACCTTGGΆTGATATTT

TCATATCTCCTTTGGAGGATATTTACTTTGTCAATGAATTGCAAGGTACTGAT

TTGCATAGGTTATTGAACTCAAGACCTTTGGAGAAACAATTTATTCAATATTT

CACATACCAAATAATGAGAGGTTTAAAATACATTCATTCTGCCGGTGTTΆTTC

ATCGTGATTTGAAACCATCCAACATCTTGATCAATGAAAACTGTGACTTGAAA

ATCTGTGΆCTTTGGTCTTGCAAGACTTCAAGΆTCCACAAATGACGGGTTACGT

GTCAACCAGATATTATCGAGCACCAGAAATCATGTTAACTTGGCAAAAATACG

ACACTGAAGTCGACTTGTGGTCTGTGGGTTGTATCTTAGCCGAAATGATTGAA

GGGAAACCACTATTCCCCGGGAAAGATCACGTGCATCAATTCTCCΆTTATAAC

AGAATTATTGGGCTCACCTCCTGCTGATGTGATCGATACTATTTGTTCCGAAA

ACACTTTAAGATTTGTCCAATCATTACCACATAGAGACCCTATCCCATTTAGT

GAAAGATTTGCTTCCTGTACTCACGTTGAACCGGAGGCTATTGATTTATTGGC

TAAATTGTTGGTTTTTGACCCTAAGAAAAGAATCAGTGCTGTTCAAGGTTTGA

CCCATCCTTATATGGAGGCATACCATGATCCAACCGATGAGCCTGTTTGTGAG

AGTAAATTCGATTGGAGTTTTAATGΆCGCAGACTTGCCAGTGGATACTTGGAG

AGTTATGATGTACAGTGAAATTTTAGACTTTCATCAAACTGTTGGTGTGGCAA

ATGAAACTGAGGGTTCCGAACAACCAGACCTGCAAGTGGAGCAAAACAACTTG

GATTCCGCCAACGGAGCTTAA HWPl; ATGAGATTATCAACTGCTCAACTTATTGCTATCGCTTATTACATGTTATCAAT 86 U64206 ; TGGGGCCACTGTCCCACAGGTAGACGGTCAAGGTGAAACAGAGGAAGCTCTTA 4028879 TTCAAAAGAGATCTTATGATTACTATCAΆGAACCATGTGATGATTACCCACAA

CAACAACAACAACAAGAGCCTTGTGATTACCCACAACAACAACAGCAGGAAGA

ACCTTGTGATTACCCACAΆCAACAACCACAΆGAGCCATGTGACTATCCACAAC

AGCCACAAGAACCTTGTGACTACCCACAACAACCACAAGAACCTTGTGACTAC

CCACAACAACCACAAGAACCTTGCGACAATCCACCTCAACCTGATGTTCCTTG

TGACAATCCTCCTCAACCTGATGTTCCTTGTGACAATCCTCCTCAACCTGATA

TTCCTTGTGACAATCCTCCTCAACCTGATATTCCTTGTGACAATCCTCCTCAA

CCTGATCAGCCTGATGACAATCCTCCTATTCCAAACATTCCAACCGATTGGAT

TCCAAATATTCCAACTGATTGGATCCCAGATATTCCAGAAAAGCCAACAACTC

CAGCTACTACTCCAΆACATTCCTGCTACAACTACTACTTCTGΆATCATCATCT

TCTTCTTCTTCTTCATCATCATCTACTACTCCAAAAACTTCTGCTTCAACTAC

ACCTGAATCTTCTGTTCCAGCTACCACTCCAAACACTTCTGTTCCAACAACTT

CTTCAGAATCAACTACTCCAGCTACTAGCCCAGAAAGTTCTGTTCCAGTTACT

TCTGGΆTCATCTATTTTAGCTACCACTTCAGAATCATCATCTGCTCCAGCTAC

TACTCCAAATACATCTGTTCCAACCACTACTACTGAAACCAAATCATCAAGTA

CTCCATTAACTACTACTACTGAΆCATGATACAACTGTTGTCACTGTTACTTCA

TGTTCTAACAGTGTTTGTACCGAAAGTGAAGTTACTACTGGTGTTATTGTCAT

CACATCTAAAGATACTATTTACACCACTTACTGTCCΆTTGACTGΆAACTACTC

CAGTTTCTACTGCTCCAGCCACTGAAACACCAACTGGTACAGTATCCACTTCT

ACTGAACAATCAACTACTGTTATTACTGTTACTTCATGTTCTGAAAGCTCTTG

TACCGAATCTGAAGTTACTACTGGTGTTGTTGTTGTTACTTCTGAGGAAACTG

TCTACACTACATTCTGTCCATTGACTGAAAACACTCCAGGTACTGATTCAACT

CCAGAAGCTTCCATTCCACCTATGGAAACAATTCCTGCTGGTTCAGAATCATC

CATGCCTGCCGGTGAAACCTCTCCAGCTGTTCCAAΆATCAGATGTTCCAGCTA

CTGAATCAGCTCCAGTTCCTGAAATGACTCCAGCTGGTTCACAACCATCTATT

CCTGCCGGTGAAACCTCTCCAGCTGTTCCAAAATCAGATGTTCCAGCTACTGA

ATCTGCTCCTGCTCCTGAAATGACTCCAGCTGGTACTGAAACTAAACCAGCTG

CTCCAAAATCATCAGCTCCTGCCACTGAACCTTCCCCAGTTGCTCCAGGTACT

GAATCCGCACCAGCTGGTCCAGGTGCTTCTTCTTCTCCAAAATCTTCTGTTTT

GGCTAGTGAAACCTCACCAATTGCTCCAGGTGCTGAAACCGCTCCAGCTGGCT

CAAGTGGTGCTATTACTATTCCGGAATCTAGTGCTGTCGTCTCTACGACTGAA

GGTGCTATTCCAACTACATTAGAATCAGTTCCACTCATGCAACCATCTGCCAA

TTACTCAAGTGTCGCTCCTATTTCTACATTTGAAGGTGCTGGTΆACAACATGA

GATTGACTTTCGGTGCTGCTATTATTGGTATTGCTGCATTCTTGATCTAA

INTl; ATGAACTCAACTCCAAGTAAATTATTACCGATAGATAAACATTCTCATTTACA 87

U35070; ATTACAGCCTCAATCGTCCTCGGCATCAATATTTAATTCCCCAACAAAACCAT

1144530 TGAATTTCCCCAGAACAAATTCCAAGCCGAGTTTAGATCCAAATTCAAGCTCT GATACCTACACTAGCGAACAAGATCAAGAGAAAGGGAAAGAAGAGAAAAAGGA CACAGCCTTTCAAACATCTTTTGATAGAAATTTTGATCTTGATAATTCAATCG ATATACAACAAACAATTCAACATCAGCAACAACAGCCACAACAACAACAACAA CTCTCACAAACCGACAATAATTTAATTGATGAATTTTCTTTTCAAΆCACCGAT GACTTCGACTTTAGACCTAACCAAGCAAAATCCAACTGTGGACAAAGTGAATG AAAATCATGCACCAACTTATATAAΆTACCTCCCCCAACAAATCAATAATGAAA AAGGCAACTCCTAAAGCGTCACCTAAAAAAGTTGCATTTACTGTAACTAATCC CGAAATTCATCATTATCCΆGATAATAGAGTCGAGGAAGAAGATCAAΆGTCAAC AΆAΆAGAAGATTCAGTTGΆGCCACCCTTAATACAACATCAATGGAAAGΆTCCT TCTCAATTCAΆTTATTCTGATGAAGΆTΆCAAATGCTTCAGTTCCACCAACACC ACCACTTCATACGACGAAACCTACTTTTGCGCAATTATTGAACAAAAACAACG AAGTCAATCTGGAACCAGAGGCATTGACAGATATGAAATTAAAGCGCGAAAAT TTCAGCAATTTATCATTAGATGAAAAAGTCAATTTATATCTTAGTCCCACTAA TAATAACAATAGTAΆGAATGTGTCAGATATGGATCTGCATTTACAAAACTTGC AAGACGCTTCGAAAAACAAAACTAATGAAAATATTCACAATTTGTCATTTGCT TTAAAAGCACCAAAGAATGATATTGAAAACCCΆTTAAACTCATTGACTAACGC AGATATTCTGTTAΆGATCATCTGGATCATCACAATCGTCATTACAATCTTTGA GGAATGΆCAATCGTGTCTTGGAATCAGTGCCTGGGTCACCTAΆGAAGGTTAAT

CCTGGΆTTGTCTTTGAΆTGACGGCATΆAAGGGGTTCTCTGATGAGGTTGTTGA

ATCATTACTTCCTCGTGACTTATCTCGAGACAAATTAGAGACTACAAAAGAAC

ATGATGCACCAGAΆCACAΆCAATGAGAATTTTATTGATGCTAAATCGACTAAT

ACCAATAAGGGACAACTCTTAGTATCATCTGATGATCATTTGGACTCTTTTGA

TAGATCCTATΆACCACACTGAACAATCAATTTTGAATCTTTTGAATAGTGCAT

CACAATCTCAAΆTTTCGTTAAATGCATTGGAAΆAACAAAGGCAΆACACAGGAA

CAAGAACAAACACAAGCGGCAGAGCCTGAAGAAGAAACTTCGTTTAGTGATAA

TATCAAAGTTAAACAAGAGCCAAAGAGCAATTTGGAGTTTGTCAAGGTTACCA

TCAAGAΆAGAACCAGTTCTGGCCACGGAAATAAΆΆGCTCCAAAΆAGAGAATTT

TCAAGTCGAATATTAAGAATAAAAAATGAAGATGAAATTGCCGAACCAGCTGA

TATTCATCCTAAAAAΆGAAAATGAAGCAAACAGTCATGTCGAAGATACTGATG

CATTGTTGAAGAAΆGCACTTAATGATGATGAGGAATCTGACACGACCCAAAAC

TCAACGAAAATGTCAATTCGTTTTCATATTGATAGTGATTGGAAATTGGAAGA

CAGTAATGATGGCGATAGAGAAGATAATGATGATATTTCTCGTTTTGAGAAAT

CAGATATTTTGAΆCGACGTATCACAGACTTCTGATATTΆTTGGTGACAAATAT

GGAAACTCATCAAGTGAAΆTAΆCCACCAAAACATTAGCACCCCCAAGATCGGA

CAACAATGACAAGGAGAATTCTAAATCTTTGGAAGATCCAGCTAATAATGAAT

CATTGCAACAACAATTGGAGGTACCGCATACAAAAGAAGATGATAGCATTTTA

GCCAACTCGTCCAATATTGCTCCACCTGAAGΆATTGACTTTGCCCGTAGTGGA

AGCAAATGATTATTCATCTTTTAATGACGTGACCAAAACTTTTGATGCATACT

CAΆGCTTTGAAGAGTCATTATCTAGAGAGCACGAAACTGATTCAAΆACCAATT

AATTTCATATCAATTTGGCATAAΆCAAGAAAAGCAGAAGAAACATCAAATTCA

TAAAGTTCCAΆCTAAACAGATCATTGCTAGTTATCAACAΆTACAAAAACGAAC

AAGAATCTCGTGTTACTAGTGATAAAGTGAAAATCCCAΆATGCCATACAATTC

AAGAAATTCAAAGAGGTAAATGTCATGTCAAGAAGAGTTGTTAGTCCAGACAT

GGATGATTTGAATGTATCTCAATTTTTACCAGAATTATCTGAAGACTCTGGAT

TTAAAGATTTGAATTTTGCCAACTACTCCAATAACACCAACAGACCΆΆGAAGT

TTTACTCCATTGAGCACTAAAAATGTCTTGTCGAATATTGATAACGATCCTAA

TGTTGTTGAACCTCCTGAACCGAAATCATATGCTGAAATTAGAAATGCTAGAC

GGTTATCAGCTAATAAGGCAGCGCCAAATCAGGCACCACCATTGCCACCACAA

CGACAACCATCTTCAACTCGTTCCAATTCAAΆTAAACGAGTGTCCAGATTTAG

AGTGCCCACATTTGAAATTAGAAGAACTTCTTCAGCATTAGCACCTTGTGACA

TGTATAΆTGATΆTTTTTGATGΆTTTCGGTGCGGGTTCTAΆACCAACTATAAAG

GCAGAAGGAATGAAAACATTGCCAAGTATGGATAAAGATGATGTCAAGAGGAT

TTTGAATGCAAAGAAΆGGTGTGΆCTCAAGATGAATΆTATΆAATGCCAΆACTTG

TTGATCAAAAACCTAAAAAGAATTCAATTGTCACCGATCCCGAAGACCGATAT

GAAGAATTACAACAAACTGCCTCTATACACAATGCCΆCCATTGATTCAAGTAT

TTATGGCCGACCAGACTCCATTTCTACCGACATGTTGCCTTATCTTAGTGATG

AATTGAAAAAACCACCTACGGCTTTATTATCTGCTGATCGTTTGTTTATGGAA

CAAGAAGTACATCCGTTAAGATCAAACTCTGTTTTGGTTCACCCAGGGGCAGG

AGCAGCAΆCTAATTCTTCAATGTTACCAGAGCCAGATTTTGAATTAATCAATT

CACCTGCTΆGAAATGTGCTGAACAΆCAGTGΆTAATGTCGCCATCAGTGGTAAT

GCTAGTACTATTAGTTTTAΆCCΆATTGGATΆTGAATTTTGATGΆCCAΆGCTAC

AATTGGTCAAAAAATCCAAGAGCAACCTGCTTCAAAATCCGCCAATACTGTTC

GTGGTGATGATGATGGATTGGCCAGTGCACCTGAAΆCACCAAGAACTCCTACC

AAAAAGGAGTCCATATCAAGCAAGCCTGCCAAGCTTTCTTCTGCCTCCCCTAG

AAAΆTCACCAATTAAGATTGGTTCACCAGTTCGAGTTATTAAGAAAAATGGAT

CAATTGCTGGCATTGAACCAATCCCAAAAGCCACTCACAAACCGAAGAAATCA

TTCCAAGGAAACGAGATTTCAAACCATAAΆGTACGAGATGGTGGAATTTCACC

AAGCTCCGGATCAGAGCATCAACAGCATAATCCTAGTATGGTTTCTGTTCCTT

CACAGTATACTGATGCTACTTCAACGGTTCCAGATGAAAACAAAGATGTTCAA

CACAAGCCTCGTGAAAAGCAAAAGCAAAAGCATCACCATCGCCATCATCATCA

TCATCATAAACAAAAAACTGATATTCCGGGTGTTGTTGATGATGAAATTCCTG

ATGTAGGATTACAAGAACGAGGCAAATTATTCTTTAGAGTTTTAGGAATTAAG

AATATCAATTTACCCGATATTAATACTCACAAAGGAAGATTCACTTTAACGTT GGATAATGGAGTGCATTGTGTTACTACACCAGAATACAΆCATGGACGACCATA

ATGTTGCCATAGGTAAAGAATTTGΆGTTGACAGTTGCTGATTCATTAGAGTTT

ATTTTAACTTTGAAGGCATCATATGAAAAACCTCGTGGTACATTAGTAGAAGT

GACTGAAAAGAAAGTTGTCAAATCAΆGAAATAGATTGAGTCGATTATTTGGAT

CGAAAGATATTATCACCACGACAAAGTTTGTGCCCACTGAAGTCAAAGATACC

TGGGCTAATAAGTTTGCTCCTGATGGTTCATTTGCTAGATGTTACATTGATTT

ACAACAATTTGAAGACCAAATCACCGGTAAAGCATCACAGTTTGATCTCAΆTT

GTTTTAATGAATGGGAAACTATGAGTAATGGCAATCAACCAATGAAAAGAGGC

AAACCTTATAAGATTGCTCAATTGGAAGTTAAAATGTTGTATGTTCCACGATC

AGATCCAΆGAGAΆATATTACCAACCAGCATTAGATCCGCATATGAAAGCΆTCA

ATGAATTAAACAATGAACAGAATAATTACTTTGAAGGTTATTTACATCAAGAA

GGAGGTGATTGTCCAATTTTTAAGAAACGTTTTTTCAAATTAATGGGCACTTC

TTTATTGGCTCATAGTGAΆATATCTCATAAAACTAGAGCCAAΆATTAΆTTTAT

CAAAAGTTGTTGATTTGATTTATGTTGATAAAGAAAACATTGATCGTTCCAAT

CATCGAAATTTCAGTGATGTGTTATTGTTGGATCATGCATTCAAAATCAAATT

TGCTAATGGTGAGTTGATTGATTTTTGTGCTCCTAATAAACATGAAATGAAAA

TATGGATTCAAAATTTACAAGAAATTATCTATAGAAATCGGTTCAGACGTCAA

CCATGGGTAΆATTTGATGCTTCAACΆACAACAACAACAACAACAACAACAAAG

CTCCCAACAGTAA

KEX2; ATGTTGCCAATAAAATTACTAATATTTATATTGGGATATTTATTATCACCAAC 88

AF022372; TTTACAACAATATCAACAAATTCCTCCTCGAGATTATGAAAATAAΆAATTATT

2511731 TTTTAGTTGAATTAAΆTACTACTAΆTTCTCAAAAACCTTTAATTGATTTCATA

TCCCATTATAGGGGTCATTATAATTTTGAACATCAATTATCATCATTAGATAA

TCATTATGTTTTCAGTATTGATAAATCTCATCCTCATAATTCGTTTTTAGGTA

ATCATAATTCAAΆTGAATATAATTTAATGAAACGΆCAATTAGGTCΆTGAACAA

GATTATGATGAATTGATTTCTCATGTTGAATCTATTCATTTATTACCCATGAA

AAAACTTTCTAAAAGAATACCTGTCCCTATTGAAΆTGGAΆGATGTGGTGTTTG

ATAATCGTGATGATACTGGTTCTGATAATCATGAGGCAACAGATGAAGCTCAT

CAAAAATTGATAGAΆATTGCTAAGAΆATTAGATATTCATGATCCAGAATTCAC

TACTCAATGGCATTTAATCAATTTAAAATATCCTGGTCΆTGATGTTAATGTCA

CTGGTCTTTGGTTAGAAGATATTTTAGGTCAAGGTATAGTCACAGCATTAGTT

GATGACGGAGTTGATGCAGAAAGTGATGATATTAAACAAAATTTTAACTCTGA

AGGGTCATGGGATTTTAΆTAATAAΆGGCAAATCTCCTTTACCTCGACTTTTCG

ATGATTATCATGGTACTAGATGTGCTGGAGAAΆTAGCTGCTGTGAAAAATGAT

GTTTGTGGTATTGGTGTAGCATGGAAATCGCAAGTTAGTGGGATTAGAATATT

ATCTGGCCCTATTACTTCATCTGATGAAGCTGAAGCTATGGTATATGGATTAG

ATACTAATGATATTTATTCATGTTCTTGGGGCCCTACTGATAATGGTAAAGTC

TTATCAGAACCAGACGTAATAGTGAAAAAAGCCATGATTAAΆGGAATTCΆAGA

AGGTCGTGATAAAAAGGGAGCAATCTATGTTTTCGCTTCTGGAAATGGTGGTA

GATTTGGTGATTCTTGTAATTTCGΆTGGTTΆTACTAATTCTATTTATTCAATT

ACTGTTGGTGCCATTGATTATAAAGGATTACATCCACAATATTCTGAAGCTTG

TTCTGCTGTTATGGTGGTTACTTATTCTTCTGGATCAGGTGAACATATTCATA

CCACTGATATCAAGAAAAAATGTTCGGCAACTCATGGTGGTACTTCTGCTGCT

GCACCTTTAGCTAGTGGGATTTATTCATTAATATTATCAGCTAATCCTAATTT

AACTTGGAGAGACGTTCΆATATATTTCTGTATTAAGTGCTACTCCTATAAATG

AAGAAGATGGTAATTATCAAΆCTACAGCTTTGAACAGAAAATATTCTCATAAA

TACGGTTATGGTAAAACTGATGCTTATAAAATGGTTCATTTCGCTAAAACTTG

GGTAAATGTTAAACCTCAAGCTTGGTATTATAGTGATATCATTGAAGTTAATC

AAACTATTACTACTΆCCCCAGΆACAGAAAGCTCCAAGTAAGCGTGATTCTCCT

CAGAAAATCΆTTCATTCATCAGTTAATGTTAGTGAGAAAGATTTAAAAATTAT

GAATGTTGΆAΆGAGTTGAACATATTACTGTTAAΆGTAAATATTGATTCTACTT

ATAGAGGTAGAGTTGGTATGAGAATTATTTCTCCCACGGGGGTTATTAGTGAT

TTAGCAACTTTCCGAGTTAATGATGCTTCAACTAGAGGATTTCAAΆATTGGAC

ATTTATGTCAGTAGCTCATTGGGGTGAAACTGGTATTGGAGAATGGAAAGTTG

AAGTTTTTGTTGATGATTCAAAAGGTGATCAAGTTGAAATTAATTTCAAAGΆT

TGGCAATTTAGAATATTTGGTGAATCTATTGATGGTGATAAGGCAGAAGTTTA

AAΆGTTGCTAGΆGΆTGTTGGTGTGCTTGGTATATTAGGAGGACAAGCGTTGAT TGAAAATGTTGAAGGTATTTGGGAAGAGTTGACTGATAATGTCAATGCCATGG CTCTTAΆTTTGACTACACAAGTGAGAAATATTGCCAATGTCACCACTGCCGTT

GCCAAGGGGGATTTGTCGAAAAAAGTCACTGCTGATTGTAAGGGAGAAATTCT

TGATTTGAAΆCTTACTATTAATCAAATGGTGGΆCCGATTACAGAATTTTGCTC

TTGCGGTGACGACATTGTCGAGAGAGGTTGGTACTTTGGGTATTTTGGGTGGA

CAAGCTAACGTACAGGATGTTGAAGGTGCTTGGAAACAGGTTACAGAAAATGT

CAΆCCTAATGGCTACTAΆTTTAACTAACCAAGTGΆGATCTATTGCTACAGTTA

CTACTGCΆGTTGCGCATGGTGATTTGTCGCAAAAGATTGATGTTCATGCCCAG

GGAGAGATTTTACAATTGAAAAATACAATCAACAAGATGGTGGACTCTTTGCA

GTTGTTTGCATCAGAAGTGTCGAAAGTGGCΆCAAGATGTTGGTATTAATGGAA

AATTAGGTATTCAAGCACAAGTTAGTGATGTTGATGGATTATGGAAGGAGATT

ΆCGTCTAΆTGTAΆΆTACCATGGCTTCAAATTTAACTTCGCAAGTGAGAGCTTT

TGCACAGATTACTGCTGCTGCTACTGΆTGGGGATTTCACTAGATTTATTACTG

TTGAAGCACTGGGAGAGATGGATGCGTTGAAAACAAAGATTAATCAAATGGTG

TTTAACTTAAGGGAATCGCTTCAAAGGAATACTGCGGCTAGAGAAGCTGCTGA

GTTGGCCAATAGTGCGAAATCCGAGTTTTTAGCAAACATGTCGCATGAGATTA

GAACACCATTGAATGGGATTATTGGTATGACTCAGTTGTCGCTTGATACAGAG

TTGACACAGTACCAACGAGAGATGTTGTCGATTGTGCATAΆCTTGGCAAATTC

CTTGTTGACCATTATAGACGΆTATATTGGATATTTCTAAGATTGAGGCGAATΆ

GAATGACGGTGGAACAGATTGATTTTTCATTAAGAGGGACAGTGTTTGGTGCA

TTGAAAACGTTAGCCGTCAAAGCTATTGAAAAAAACCTAGACTTGACCTATCA

ATGTGATTCATCGTTTCCAGATAATCTTATTGGAGATAGTTTTAGATTACGAC

AAGTTATTCTTAACTTGGCTGGTAATGCTATTAAGTTTACTAAAGAGGGGAAA

GTTAGTGTTAGTGTGAAAAAGTCTGATAAAATGGTGTTAGATΆGTAΆGTTGTT

GTTAGAGGTTTGTGTTAGCGACACGGGAATAGGTATAGAGAAAGACAAATTGG

GATTGATTTTCGATACCTTCTGTCAΆGCTGATGGTTCTACTACAAGAAΆGTTT

GGTGGTACAGGTTTAGGGTTGTCAATTTCCAAACAGTTGATACATTTAATGGG

TGGAGAGATATGGGTTACTTCGGAGTATGGATCCGGATCAAACTTTTATTTTA

CGGTGTGCGTGTCGCCATCTAATATTAGATATACTCGACAAACCGAACAATTG

TTACCATTTAGTTCCCATTATGTGTTATTTGTATCGACTGAGCATACTCAAGA

AGAACTTGATGTGTTGAGAGATGGAATTATAGAACTTGGATTGATACCTATAA

TAGTGAGAAATATTGAAGATGCAACΆTTGΆCTGAGCCGGTGAAΆTATGATATA

ATTATGATTGATTCGATAGAGATTGCCAAAAAGTTGAGGTTGTTATCGGAGGT

TAAATATATTCCGTTGGTTTTGGTCCATCATTCTATTCCACAGTTGAATATGA

GAGTATGTATTGATTTGGGGATATCTTCCTATGCAAATACGCCATGTTCGATC

ACGGACTTGGCCAGTGCGATTATACCAGCGTTGGAGTCGAGATCTATATCACA

GAACTCAGACGAGTCGGTGAGGTACAAAATATTACTAGCAGAGGACAACCTCG

TCAATCAGAAACTTGCAGTTAGGATATTAGAAAAGCAAGGGCATCTGGTGGAA

GTAGTTGAGAACGGACTCGAGGCGTACGAAGCGΆTTAAGΆGGAATAΆATΆTGA

TGTGGTGTTGATGGATGTGCAAATGCCTGTAATGGGTGGGTTTGAAGCTACGG

AGAAGATTCGΆCAATGGGAGAAAAAGTCTAACCCAATTGACTCGTTGACGTTT

AGGACTCCAATTATTGCCCTCACTGCACACGCCATGTTAGGTGATAGAGAAAA

GTCATTGGCCAAGGGGATGGACGATTATGTGAGTAAGCCATTGAAGCCGAAAT

TGTTAATGCAGACGATAAACAAGTGTATTCATAATATTAACCAGTTGAAAGAA

TTGTCGAGAAATAGTAGGGGTAGCGATTTTGCAAAGAAGATGACCCGAAACAC ACCCGGAAGCACGACCCGTCAGGGGAGTGATGAGGGGAGTGTAGAGGACATGA TTGGGGACACTCCCCGTCAAGGGAGTGTTGAGGGAGGGGGTACAAGTΆGTAGA CCAGTACAGAGAAGGTCTGCCACAGAGGGGTCGATCACTACAATTAGTGΆACA AATCGACCGTTAG

PLDl; ATGCTGCCAACAGCCGAACAACCCATTTCACCATTAGATGAGAACCCATTGGA 91

AB010810; TGAAAATGTTAATAATCTGAAACTAAAAGCTTCTTCTGCCAΆTGACAAAGAGG

3413517 ATGGTAGTTACAATTTGAAAGCAGTACAGCAAGATGGAACCATTGACGATAAC GATGCTTTACGAAAACTGCTGGATATAGACAGAATTTTTCGATCTGTCCATAG TGGACCAATTCTCCCAGAACATAGGTCTCCTTCCCCAAATACTCGTGACGACT CATCACAAGTAATTGGTAATCCTCTTTCATTTTATTATTCCAATGACGATAAG GAGTCCCGATATGATGAGGATAGATCACAGAGACAACTGCTTGGAΆΆGAACAA

GTATCCAGAAGACGAACAACAACTTCCCAACCGCTTTGAACTTGTGGATGΆTG

AAGATATAAACAAAGCTCCACCGAGAAAGGAGTCGTCAAGACCTACACATTCT

CGTTCGGCAACTTTGAGTGGTTTTATGCAGTCAAGAATTTTAGGGAGATCAAC

GTCCACTAATCAAGAAATGCCAAΆTACTGAGCCCGAATTTGCΆAATTTACATG

ATGCCTTGCACCCTAGAGAAGACAGCACTAAGAGTGGCAGATTTATAAAGACA

TTGCGTCGTTTCAATAGAAGAAAGACTAAAGATAAGCGACAAAGCACCATGAC

TGCCGAGTTTGΆTGAGCTTΆATGACGAGTCTGAAAATGCCACTATCGAAAGGG

CAGAAAAGTTACTAGCAGGTATGTCCACTGGTGCTCCTGCAATCAATTTAATG

GCCTCGTGTCTATTAGAAGATGAACATGGTATAACCAGAGCCCCGTTATTGTT

GTCAGTGCTTGGGTTCAAGTTGAGCGACGTTACTCCAAAAGAGACAAGCAGAA

ACAGGAGATTTAGAATTGATTTAGAATACGGAATTGACAAGCACAGAATGAAA

TGGAGTATTGAGAGAAACGCCACTGACTTGGCTTATTTAGCTTACAΆACTCGA

GAGAACAAGΆATTGTAAGTAGAGTTGTGGGAAΆCAAATCTCAACCATTACCCA

GACTTCCAATTCCACCAATTCGAAAATTGGATAACAAAAGAAGCAAAAAGACT

AAAAGTGTTTTATCTGATCTGCGTGCAAGAGACGACCGCATGTCAGTACCAGA

TATTAACGATAACCACTCGCTTTCACCAGTACCATCAGCTTTGTCTAGAGTGA

GACTGCGTTTGGGAΆGTATAACATCAGTGGGCTCACTTGAAAAGCATCCAGAG

TTGCTTGAGCTCAGACGGAAAAAGAATGCACAATTTATGAAAGATGTTGAGAG

TTATTTGAΆGGΆATTGATTGAAΆTTACAGAGTTAAAAACCCTGGCAΆATATTT

TGTTTACTTTCTTTGAGTTGTCACCGCTCTCGTCATTATTGAGTTATGAATCT

GGCTATACTGGTAAGCAGGGTCCAGTCCATΆTTGGGGGAACTGCTAAAGCACA

AGGTTGGAGAGTTGGCCATTTCAAAGTAAACGATTTGAAAGGAATCTACGAGA

GAAGAGTTGAAAΆGTGGATGCTTGTGAGAAACAGTTACATCACATATGTCTCG

GATATTAΆCTCGACTACACCGTTAGATGTATTTTTGGTAGATAGTGATTTCAA

GATCAGTGCCAGΆΆACTTGGAGATTGCAAACAGAGATGATGATGATTCATTGT

TTGACAACTCTTCCGTTGCCCAGCAΆCAAATGCATGAAAATGAAAACAAGTTT

TTCCCACATTTGAAAATCACTTTGGAAAATAGAGAAAGAAΆATTAGTGATGCT

GCCAAAATCTCAAAGAGAGCATTCTCTTTGGATTGACTCTCTTAGAACTATGC

AAAATCTGACAATATGGTCCCAAAATΆΆGAGATTTGATTCTTTTGCCCCAGTT

AGAGAAAATTGTTTTGCTCAGTGGTTTGTTGACGCTAGAGACTACTTTTGGGC

TGTCTCCACTGCTTTGGAAATGGCCAAGGATACCATTATGATACACGATTGGT

GGCTTTCTCCGGAATTΆTATCTTCGAAGACCAGCAΆATGGTAΆCCAΆCAATAC

AGAATTGATAGATTGTTGCAAAGAAAAGCTAAGGAAGGTGTTAAGATTTTTGT

GATTATTTATAGAAACGTTGGTACAACGGTTGCAACTGACTCATTATACACAA

AACATTCCATATTGTCTCTTGATGAAGAGAATATTCATGTTATTAGGTCACCA

AATCAGCTTCTTCAAAATACATTCTTTTGGGCTCATCACGAAAAATTGTGTAT

AATCGACCACACATATGCTTTCTTGGGTGGTATAGATTTATGTTATGGAAGAT

ACGACACGCCAGATCACGCATTAACAGACGATTCAGGTGTTGATTTTTCCAAT

ATCGCACAGGΆCGATΆGAATCACAGCAGAAAACTTTGCGAΆTTTCCAAGTTTT

CGTGGGTAAAGACTATTCCAATCCTAGAGTTAΆAGATTTCCTGGAACTCGAAΆ

AGCCATATGAATCCATGTACAACAGAAATATTGTCCCTCGTATGCCTTGGCAT

GATGTTCATATGTATACATGTGGGCAGACCGCAAGAGATTTGTCCAGACATTT

TGTTCAGAGATGGAACTATTTAATCAGACAAAAGCGGCCAAGTAGACTCACTC

CACTTTTGTTGCCTCCATCTGATTTGACTGAAGAAGAGGTATTAGCTCATGGA

TTGGATGGTACATGTGAGGTGCAGTTGTTAΆGATCATCCGGAAATTGGTCACT

TGGTTTGAAAGAACACGAGCAAAGTATTCAAAATGCGTATCTTAAATTAATAG

AAACTTCCGAGCATTTTGTCTATATTGΆGAATCAATTCTTCGTAACAGCTTGT

TTCATCGACGGTACAGAAATTAΆGAATAGAATTGGTGATGCGTTGGTCGACAG

AATCATTCGAGCACATAGAGAAGGTACTAATTGGAAGGCTATTATTGTCATAC

CTTTGATGCCTGGTTTTGAAGCTCAAGTTGATGAAGCAGAAGGGTCTTCTGTT

CGTGTGATCATGCAATGTCAATΆTATGTCAATTTCCAGΆGGTGΆAACGTCTAT

TTTTGCAAAATTGAGGAAAAAGGGAATTGATCCAGACCAATACATTCAATTTT

TCTCCTTGCGGAAATGGGGTAGAΆTAGGATCAAACAGAACTTTAGTTACCGAG

CAGTTGTATATTCATGCAΆΆGACGATGATTGTCGATGACAGATCGGTTATCAT

TGGGAGTGCCAACATCAACGAGAGGTCTATGCGTGGTTTGCGTGATTCCGAAG TTGCTGCAGTTGTTCGTGACAAGGAAATGGTAΆAGAGTAAAATGAATGGTAAG

CCATATATGGCAGCTAAGTTTGCTCACACATTGAGAATGAGGTTGATGAGAGA

GCATCTTGGAGTTAACATTGATATTGTTGATGTGGTTGAΆAGAAGGTTTAAGA

GATTTGAAAATTTTGCTGCTTCAGAGGAAGGTAAAAAATTCGCCACCAACAAG

TTTAGAAACCCCGAGAACCGTACATTGTCTGCTATGGTAGAGATTGCATCGAG

AGATATCTTGCAACAACCAGAGGGAACCAGAAGATGGAAGGAGTTTATCCATG

TGTCGAAATΆTGATGCTGAAATTGCCGAGGTTAΆCTTTGΆGGAAGAGGACACA

TCGTTACCTCCACCTCTTTTCTTACCAATTTCATTCAACAACCGAACAGGGCC

ATTTGAΆGCCAATAAAGGTGTCCGTGACAGCAAGAAGCATTCATACGATAACA

GAGTTCAAAATAGCGAGTCACATAΆAAAGGATGTTTACGGTGAAGGGTTGGΆT

AAATACAGGTCGAAGTTAGCCAAGAGAGCAAGGGTTAGCAGTGGTAAATTTTT

GAATGAGCTTTCCCTCCTTGCCATGGAAACTAATCCTACAGGGTCGTTTTTGC

CTGATTTCGATAGTGTTAGGAACTTTTTGGAGTCAGATGATTGTCATATGAGT

GGAGAAATGGATGACGAΆTCCGAAGATATCATTGCAGAAAGAAATAAGGAAAG

ATGGATGTTGCTCAAGAAAATCTCTTATTTACAAAGACTTGCCGCCAGAGAAA

AGAGCATGAATGATACAGAGAACCAAAAAAGGGCAAAATTGGGATTACCGCTC

TTGTCTAAAACTGGAAΆTGCTGTTAATGGTAACGAATCΆCAAGAATTGCCTGT

CAGTGCCACATTACCTATTTCCGAGGGAATTGACACGGATTTCAGTTTGGATA

AAGAGTTCCCTACTGTATCTTTGAGTGAACCCGCTGCTAGΆGATATCΆTCAAC

AATTTGACAACCCCTGATGCTGCTGTAAGTAATTTTGTTGATCCATATGAATT

TGAAGATCCAATTGATCCTGΆTTTCTATGAAGCACGATGGAATGAATTTGCAA

GAAGAAACACTGATATATACCGTATGGTGTTCCATTGTCAACCTGATGATGTG

GTGGGTAGATGGTCAGAGTACACACACTTTACAAAATTACAGAGTΆTGTTTAT

GAAAGCTCAGGATACAGACACCGACCAAGGTCAACTGGCAGAAAACTACTCCG

ATGAAAAAGTCGAAGCTGGTGATAΆCCAAGAACCACGACGTGCAAACAATTCC

AAACTAGAAAAAATTGΆCGΆΆGCGAGTGΆΆGACGAGTΆTGGTTTGTTAGGTAΆ

GGCACCACCAGAGAGAGGTCTTGAGAATCAAAATAAACTGGAACAAGAGACCA

ACTTGAGGGCTAAACTTAGTCGTCGTGTTAGCACATTTGCTGGTGTGACAGAA

AACCGGGATAAACATTTTAGTGACAAAGCAGCGCCTAAATCCGAGGGTGAACT

TCAΆGGTGGGGAΆAAGACAAGTACAGAAGAAGAAGAATCAGAGGAATCGGGAA

CACCTACTGATAAACCTTCTGCTACTGCTGGAACAGTACCAGCATCCAAAACC

AGGAAAAGGGCACGTACTTATTTAGCTAGAAGAAAΆATTCAAACCGGTGATGT

TGTATATGATAAGAATTCAGCTGAGAGATTATTGAATGCGGTGCAGGGACACT

TGGTGTACTTTCCAGCGGAATGGTTAAGCGTTGAATTGCGAAACAATAATTGG

TTCTACAACACCGATAGACTTCCACCTATGGAAATTTACGATTGA

PMTl; ATGGCAAAGAAACCGGTCACACCCGCTTCTAAAGTTGCTGCAAAACAGGCTGC 92

AF000232; TGTTAGAAGCAGACACCAAGAAGATGTATTCACACTTGATCCATTGATAGATC

3411012 CAATATTTCAΆAAGGGAGAATTGCGTTCGTATTTGGTAACCGΆΆCCTTCTCCT

AGTGTTCTTAAAAAAAGACTGATTCACACCAAAGAATACTGGATGCTTTCAAG

TTTATTATTAATTGCTTTCTACGTTAGGATGTATAATTTATCCAATCCAAACT

CAGTAGTTTTCGATGAAGTCCATTTTGGTGGGTTTGCCAGAAAATATATTTTG

GGTACTTTTTTCATGGATGTACACCCTCCATTGGCTAAAATGCTTTTTGGAGC

TGTTGGAGCCATTGGTGGATTCAAAGGTGATTTTGAATTTAAATCAATTGGTG

ATAAATTTCCTGATTCTACACCTTATATATTTATGΆGACAATTCCCΆGCΆTTG

TTGGGTGTTGGAACTGTTATCTTGTGCTATTTGACTTTGAGACAATCAGGTGT

TAGACCAATTATTGCTTATATAACTACCTTTTTATTGATTATTGAAAΆCTCCA

ATGTCACTATTTCAAGATATATTTTGTTAGATTCCCCCTTGATTTTCTTTATT

GCTGCTGCTATTTATGCTTGGAAGAAATTTGAAATTCAAATTCCATTCACCTT

TGGCTGGTATAGAAGTTTATTGGCAACTGGTATTGCTCTTGGTTTAGCATTGA

GTTCCAAATGGGTTGGTTTGTTTACCGTTGCCTGGGTTGGTTTCTTATGTATC

TACCAATTGTGGTTCCTTATTGGTGATTTATCAGTAAGTACCAAAAAAATTTG

GGGCCATTTTTTCGCAΆGAGGAATTATCTTGTTGGGTGTACCAATTGCCTTAT

ATCTTGGATTTTTTGCCATTCATTTCCAATTATTAAATAΆAGAAGGTGATGGA

GGTGCCTTTATGAGTAGTGCCTTTAGAGCCGGATTGCAAGGTAATAAAATTCC

AAGAGATATTACCGAACAAGTTGGATTAGGATCAGTTGTTACTATTCGTCACG

TTGATACTCAAGGTGGATATTTGCATTCACATGAACATTTCTATCAAACAGGT

TATACTTATGATTCATGTGATGCTGGTATTACACCTAATCAATCTTCTCCAGA TGGGATTTCTTATTTACCAGGTCAAAGATTAAATAAATGTACTTGTCCAGGTG AAGCTCATCCTAΆTCGTGGTGTTGGTAGΆGGTGCCCCTGAAATTGATGCATTG GAAGGGGAAATTCATGGTGTTATAGGTAGAGTTTCTCAATCΆTTACAAGTTGC TCCTTATGATATTTGGTATATGCCCAATTATGATTTTCTTGAAATTCATAATA GTTCAATAACATTAATGAATACTTATGCTGGTGGACCTTTCCAACAAGCTATT TCGGGTGTAACAATGTTAAATGTTACATGGTATGAATATGGTGΆTCATCAACA TAΆTTTCCAΆAAATATGGTTATGAΆTATTTAAATGATGATGAΆTCAGGTTATT TACGTTGGTTTGTTGGTGACAATCCAACTTTTACAATCTATTCTCAAGCTTTA CATCCAAATGGTAΆTGTTGGTTGGAGAAAGTTACCTAAΆGAACCTTTAAGTTT GΆTTTTAΆΆTTTTGGTATATCTAATAATTGGGCTTATATCGATTGGCCAAGTT TAGTTTTCCCTTCAACTATGAGAGTCGATTATGTAAGAGTTTATCAACCTAAA GATCAAATTAATGTTGGTTGTGATCCAACCGATTTCCCAACTTATGΆTTATAT TCAACAACATTTAAATGTTTATCAΆAATGTTAATTTAACAAAΆTTTGAAGATG GTGGTTATACTTTCCCCAAACATAAATTAATTGGATGTTAA

SSKl; ATGAATTTTCTCTATAACAATTCAGATTATAGTAGCACATCACATACTATGAA 94

AF084608; GTCΆCCACTGGCATΆTAATCΆGTTTCCTAAACTACAGGCAAGCAATTCGACAG

5915906 CTGGTAACAATAATACAGCCACAACAGCAACGGCAGCAGCGGCAGCAGCATCA

GCATCAGCATCAGCATCAGTTACΆCCACAΆTTGATATCACCAACAΆCGTTGAC

CACACCACAGAACAAGTATAAACGTGGAGGATTGGATAATACGCTTCCCAAAA

TAGAAACTACTΆGAAAGAACAGΆCCGGATGATGGCAATTCAATCACGCCCAGC

AATTCGATCAATAGTGGTACAACAAAGTTAACCTTACCACCACGACGAGTTTG

GGTTAAGAAACCGCAAΆCAAACAACCCAACCACGGTACTTTGTTATGTGAATG

ATATAATTGΆTGATTTAAAAGTAGCAGTGGTGAACAAΆTATCCAAATACCATT

GGCAGGTACGAGGATGCTGCCGATTTGCTTGTTAAGATAGATTTGAACAACAT

CΆGAGTGCCAGTTTCCCCCAGTGTTΆATCGAGTGTCGCΆΆAGAΆCTCCATTTG

ATAATTGTΆTAATTTTGGAACCAGATCAGAACGTTTGGCAAATΆCTAGACAAT

TATTTTCCTAATGGAATGGCCATGCACGATGCCTTGATAATTGAGACACCAAC

ATTCAAACCAGACCATCAAATGCTAACACCAATAACAGCCAATATGAACAATA

ATAGTAACACTTTTATACCTTTTCAAGAACGTCAATCGAGTΆTCGGGAACAAC

AACAACAACAACAGTAATGTAAACAACAACAATAAAGCACAAGCAGTCAAACA

CCCGCAACCAATGCAACCAAACAATACTCGTGTAGGTTTACACAAGTCTTATG

CCATGAATAGGTCGAGTTTCCTGACCAATAACAACCCTGTCCCATCTATCATC

AAGGATAGATCGGTGTCACCATCAAΆCTTGGGAGTTTCAAGAAΆCTCTCCTGT

TTCCCATAAAAGATCATATTCAAATCCAGTTTCTTCACCAAATTCTGTTGCTA

CACAAGCTAATAATCCGCTGGCAGTTTTACTATTACCCAGGAATTTCTCATTA

GCTAATAΆTAATAGTAATCAAGCACTGCAAAGTAGTGGTGGAACACCTGCCAA

AAAAGTTTTATCCGAGGACGGAAGTAAΆTCGGTCAΆTGACAAGACAGAAGAAG

TTGTATCATCCAAATTGAAACCAAACGATAACAATAAAAGCTATCAAGCTAAA

CAGCAAGAACAACAAACTGCCGAACAGTCTGAAAATGGCTTTAGTGAAACTTC

AGCATCGCCTGAAGCGGTTCATAATTCTAAAGCAGCACCATTACCGTTGACCA

AATCATCAACAACTGCTACCACAACCTCTTCCAACTCCATTAGTAATAΆCAAT

AATACTAGCAGCAAAGGAAAGCCAAGTCAATCCAAATTAAAAGCAGCTAATGA

TCCAACGCCGACGGATATAGTGTTACCGTCTATTTCTGTATTGGTΆGTTGAAG

ATAATGCCATCAATCAAGCTATTTTGGGAGCATTTTTACGTAAACGTAAAATT

CATTATCAAATTGCAAAAAATGGCCAAGAΆGCAATAGATAAATGGAAAAAGGG

AGGGTTTCACTTGGTATTGATGGΆTATTCAATTGCCAGTGAAATCAGGGATTG

AAGCAACTAAAGAAATCAGACACTTGGAGAAATTGAACAGGATTGGTGTATTT

CATGAAAACGAAATTGGGAAAAATGTΆATAATTAATGAAGAAGATAGATTGAC

TTCCAATACGTTTΆGATCTCCGGTGATTATAGTTGCTTTAACCGCCAGTTCAA

ATTCTTCTGTGGATAAGACTAATGCTTTAACAGCAGGCTGTAATGATTATTTA

ACCAAACCAGTCAATTTAGTTTGGTTACAGAATAAAATCACAGAGTGGGGGTG

CATGCAAGCATTGATTGATTTTGACGGΆTGGAAΆGATAAGAATCGAAGATTAA

ACAAAGCTTGA

TPSl; ATGGTTCAAGGAAAAGTCTTGGTGGTTTCAAATAGAATACCTGTTACAATCAA 95 Y07918; AAGATTGGATAATGGTTCATACGΆTTATTCCΆTGTCCTCCGGTGGACTCGTTA

CCATTGGCTGATTTCTTAATTGAAAGAGCAGTAGAAAATGAAAAATTGGGTAA

TTTCTTTTACTGGTATGTTAAAGTTGAAAATGAAGATCAACTCAATAATCCTC

ATATCGATGGCCCAΆTCAAAATCTACATGGATATTCTTAATCGCTATATTGAA

TTGCTAAAAGCACATTGTCATGΆΆAATAGACTTCCTTACTATAΆGCATTTAAA

ACATCAAATATGGTTCATCAAGAΆATTAACTTCTTTGGTAGAGTTATTACGTG

CTTCATTTAAGAΆAAACGAGGCAACAGCAAAGAΆAGTTGAΆTATTTGCGGGAG

TATCTΆGCAAATTCTGGGAATGAATTGTTAAAATTCCCTGΆACCTTTCCCATT

ACCACTTGATCCATCAGTTATGATATGTGGATGTTATCCTGAGGAATCATCAG

TTTTCAAATCTTCATTGGCACCATTAAAAATTACTTTAAAAACCATTGAAAAG

AAGAAACACGGACATGCCACTTCGCAATTATTTGGAAAACGATCTAGATATGG

GAAATACCCGTTAATGTTTAAAATAGGTGATGATTTAAGACAGGATCAATTGG

TAATTCAAATCATAGACTTGATGGATCAACTTTTAAAGAATGAAAATCTTGAT

TTGAAACTTACACCATATAAAATATTGGCTACTAGTCCAATTTCCGGGTTGAT

TCAATTTGTTCCAAATGAΆACTTTGGACTCTATTTTGTCCAΆGACATATCCAA

CATCGGTCACATATTCTGGTGGTGGTGAAACTTCTGATGGACCACCGTCAGTA

TCAAACAATGGTATTTTAAATTATCTTCGTCTTCATAGTCAAGAACAACAATC

CGAGGΆACCTATATCCAAAAGTATTTTAAGTACAAATΆCCAGTCAGTCCAATA

CCGAGATACCAGTTTTACCACGTCAACCTAAACCAACAATAACTTCAGATTTG

GGTGTATCACCGATTCTTATGGATAATTΆCGTCAAGTCATGTGCTGGTTATTG

TGTAATTACCTATATTTTGGGTGTTGGAGATAGACACTTGGACAATTTATTAC

TTTCACCCAATGGGAAGTTTTGGCATGCCGACTTTGGATATATACTCGGCCGT

GACCCTAAACCTTTCCCTCCATTAATGAAATTGCCTATACAΆGTAATCGATGG

GATGGGAGGGTTACΆTCACGAGAATTATAATGTTTTCAAGAGCTATTGTTTTA

TCACATACACAACATTGCGTAAAAATAGTAACTTGATTTTGAACTTGTTCCAA

TTGATGTTGGATGCCAATATCCCAGATATTCAATTTGATCCACTGAGAGTGAT

TGAAAAGGTACAAGAAAAGTTTTGTTTACAAATGACTGAAGAAGAAGCAATTT

TACATTTCCAAAATTTGATTAATGATAGTGTGAATGCGTTTTTGCCTGTTGTT

ATAGATΆGATTΆCATAGTTTAGCACAGTATTGGAGAGCTTAA

Table7. AminoacidsequencesofC.albicanspredictedgeneproductsthat inhibithyphalgrowth

Table 8. DNA sequences of C. albicans genes that encode polypeptides that inhibit hyphal growth

GCTGCAATTGAAGCTAGTGCAGCAGCAGCTGTTGCGTCTCAAGGATCACCTAATG TCACTGCAGCTGCTGTAGCCGCATTACAACACACACAGGGTAATGAGCACGATGC TCAACAACAACAAGATCGTGGTGGTAΆTAACGGTGGTGCTATTGATTCAAATGTC GATCCAAGTCTTGACCCAAACGTTGACCCTAATGTTCAAGCTCATGATCATTCTC ATGGATTAAGAAATTCGTATGGGAAAAGAAGTGGGTTTTTGTAA

RFGl; ATGTCTACTGCTATCTACTATTCAACTCATAATAACATGCACACAAATGATGATA 106

AF330198; TAACTAATGGTAGTGGTTCTACTACATCTGGTAATCCAGGTGCCAACCCATCAAA

13183713 TCCTAACCACACTAATGCTGGTGCAACTATCAACAACAACAGTAATATTGGTTTA

AATTCAGCTAATAAGAACCATACCACTTTATTACCTTCTTTGGCACACΆTTATGC

CTAGCAATAGCAATAACACTACTAATAGTGGATCTTCTATTGATATAAGCTCCAC

ACTTATCAATCCATATTCAAGTGGGGCTGCCGCTGCCGCTGCTGCAGTTGGTGGT

GGTAATGGTGGATATTATCATCCTCCACCACCACATTCTCAACAACAACAACAAC

AACAATTTGATACTTCTTATTCGAATCAAACTACTCCAACTTCAGCTTATACCAA

TTTCAATAATGATTCTACACATTCACCTACΆGATATTCTGATGCAACAGAATATG

AATAATTTAGCATCTTCATCAGGAAATATGTCTATTGGTGGTGGTATTGATGGTA

ACTTTTCCCACAATAATAATAATAΆTAATAACAACAACAACAATAACAATAATAA

ATGTATTTGTAAΆTCAAAAGTCAATAAAATTCCTCGACCAAGAAATGCATTTATT

TTATTCCGACAAAAATATCATCAAATGGTATTAGATGAAGGTACTGTTATTAGAA

CCAACCCTGAAGTTTCCCGAGAATTGGGTAGACGATGGAGAGGATTATCACCTCA

AGAAAAGGAACATTGGΆATAATCTTGCTGAAGAAGAAAAGAAGAATCATGCCAAA

AAATATCCTGGGTATAGATATACTCCAAGAAGAAATGGTAGAAACAAAAATTGTC

CTGTTTGTAAAAATAAACCCCTTCCTAATAATAAATCTAATTCTATTAGTGGAAT

GAGTGGTAGTGGTGGTGGTGGTGGTAGTATATCAGGTGCTAGTAGTCTCAGTGGT

GGATTAACTTCTCGTGATAATTCAATTACTAATGCAAATGCTATTGATTATCAAC

AACAACAACTACAACAACAACAGCAACAGCAGCAACAACAAGCTATACAATTTCA

ATCATTACCACCAGATCAATATCAACAATTAATTAAGCAACAACAGCAACAATTA

CAATTGCAAGCTCAACTTAATGGAGGTGGAGGTGGAGGTGGTATAACTAGCAACC

CACAAACTATACCACAATACATTACTAATGGGAATTATCCATCATACATAATTTC

TCCAAATCCTTACTCCACTACTAGTACAACTGCTCCTACAACAACAACTACTACA

ACCACCAΆTGCATCATCAATAGGTTTATCAGTACCACCCACAGCTACAACTACΆT

CAACATCATCACAACCTACATCAGCAAΆTTCCCAATTACATTTCTATGAAGCTGA

GAAATTATCTCCAGTATCATCAACTCATCATCAAAGTAGTATAAGTGAGATAGCA

GCTCAACAGCAACAACAACAACAACAACAACAATTTATGTATAATACTAATTATA

GTACTATACCACCTAΆTAATACTACTACGATGCAΆCAACATTCCGCAGGTACAGG

AAATGATTATAGTCTCAATGGTAATAATAGTGGAAACACTGGTTATGATAATAGA

TATGGTTATGGTCAACCTATGATAATTACTGGTCAATCACAACAAGGTTTACAAG

TTCAACAACAAGGTCAACATTATAATAGTGGTTTACATGCTGCTCAACATTATCA

ACAACAACAACAACAACAACATCATCAACAACAACCTCCACAΆTAA

TUPl; ATGTCCATGTATCCCCAACGCACCCAGCACCAACAACGTTTGACAGAGTTGTTGG 107

AF005741; ATGCAATCAAAACTGAATTCGACTACGCCTCAAACGAAGCAAGCAGTTTCAAAAA

2245633 GGTCCAAGAAGATTATGACTCAAAGTACCAACAACAAGCTGCCGAAATGCAACAA

ATCCGCCAAACAGTGTATGACTTGGAGTTGGCCCATAGAAAAATCAAAGAGGCAT

ACGAGGAAGAGATATTGAGGTTAAAGAACGAGTTGGACACTAGAGACAGGCAAAT

GAAGAATGGCTTCCAACAACAACAGCAACAGCAACAACAGCAACAACAACAGCAA

CAGCAGCAACAACAACAGATTGTGGCACCACCTGCCGCCCCACCTGCTCCACCAA

CCCCGGTCACATCATTATCGGTTATCGACAAGTCACAATACATTGTCAACCCCAC

CCAAAGAGCTAACCACGTCAAGGAAATCCCACCATTCTTGCAAGATTTAGACATT

GCCAAAGCCAACCCCGAGTTCAAGAAACAGCACCTCGAΆTACTATGTGTTGTACA

ACCCAGCGTTCTCCAAAGACTTGGATATTGACATGGTCCACTCCTTAGACCACTC

GTCAGTTGTTTGCTGCGTGAGATTTTCCAGAGACGGCAAGTTCATCGCCACCGGT

TGCAACAAAACCACCCAAGTGTTCAATGTCACCACCGGAGAGTTGGTCGCCAAAT

TGATTGACGAGTCCTCCAACGAAAACAAAGACGACAACACCACCGCCTCAGGCGA

CTTGTACATCAGATCTGTGTGTTTCTCCCCTGACGGAAAACTCTTGGCGACAGGT

GCAGAAGACAAGTTGATTAGAATCTGGGATTTGAGCACAAAGAGAATTATCAAAA

TCTTGAGGGGCCACGAACAAGACATTTACTCGTTAGACTTTTTCCCTGATGGCGA

TAGGTTGGTTTCAGGCTCCGGCGATAGGTCAGTCAGAATCTGGGACTTGAGAΆCC

Table 9. Amino acid sequences of fungal cell wall proteins

EAL02119; VHAVTKPLPTDYIACTAFLHDLLVDKSNVWVPLSYIKILKEMPSΞDIRISKK 46442833 FNNIHENSEIPTIRDTELARQEAVDGTILNEFIKKSVPPRPTKRDHSRDTLLD

EIKYSLELLNAHIFAVYSKSEFRLFEKLTSIYYSLYEIRTKLNHHLLTSEEAQ

VARETATFLLNRIPKILASRASRLGKDVIELDYSDTDVSGYKSILSRDAETGE

VLSLKTALPPRIALNNELGALVPNYPINIHDNFHNYSLKPSAMKKFYHDPPSH

ILVDFKSVTGSSAYQPPGFAGMVAYMYIRNSKKRLTEAFΆVHTNSVEDFVHVE

KISAALFRNLPASEIENNRVYLVAVLTEEVDLNIKGTGHTPTIKRVKKGVAAG

VADITRIFPRAEGSLQSGΞAHNFSIKLFGSYLSKKGHKNMVEDLRGLSNNGWG

ΞLVDRIIAGSSQGVAVNPRAEKLVITVKEFKHQFQGNVANQLSSSAPISRIKP

IFFDPLAENYERIYLKMGKVTLLGSNAREDLLTFEVSTPNNELITFAKΆSNQQ

EKRYWQFISVFPGESIGEIVKVNGVALKNSSKKLPKDDYILLSLYVNGVLAGE

GRLLYKSGNRLVEFNKKKTHTIE11SATHNVPMAHIELSTEYVGKVYNSDVSI

DNIFQYERFFQNGQKGIDELSNSLVAFTRLDIAQWKYFPELLSSLYGIIGFS

SHHSGPSIEILEDNTFKAVIHLLDTVFGKQDQYLYLLDNFIAKYKSSNQIGIF

LLTKVEQIFNRAGSSWNSVSRSVCRVLSIILRISILSMNAPNEQDLYLQTLNN

LFKSIAYLLTLDSTNMIDDQVLVMDIIDYIFAFDVNFKGSELVQIMINCIDSI

GLKGVGVDELSMESTPAGSRSIKDHKIIIGKLLLILRLLNSDLVKEESSRCIL

IPKAITWAVDVFLAPTDIEATRLACSVLNAACTALWNDGVIGKYQGDMEICYS

LAKFLPAISRTFIKYNKFTRGNGSFKKKRVFTQLFPSTYPFIEFSIDPWNDE

SMVEVLVELAITFSFVARVGKEAAGNEGYITILDSRIENDFFIPEKYLASDFH

GEDILTLLSGIRYMRLGKYFPETKWYSTYSVIIEGCLCAIELVRPLVIINQLP

ALDDSESFDRTLWGNYLRSLFKLAVLPPVAVEHLSDVPKSACAKITNDVRKRA

AFLINEAWDSLAWDATDEDMLRFNLKKFGGYQVEFINDEFGILPDLMLLGLQR

DSECQSVAIKILWSIMISEYILSDTLQDVΞRQCLLGLHEIYHNNSYKPTSLDQ

ENFIERMKMTVRLDREDEAFD11YNFIQNLSSFFGTLNYYISVPFGPEYEEDR

IFHEIKLKAQIKNAGKPELFNSYIHQMYEKYLSQNDYVQAALSLELLASTYSW DHHIIVPASFRPKFPEQSSFERKEILLKMIANNFVKGNSLEKAADTYNELLDS YNEHTYDLKSFAYVHNKLAQLYLDMESSDKLTPTYFKVEAIGGGFPTYLTQIS QIFQGLPFEHITSIHERFLKVFPGAKIISDDAEAIRLKΞKATNGRYLYIKTVE PVYEFSDKLINTSLGVRQYARNKDLRFFTSLKKFPGATSVFDLWTEETTYETW LSFPTLMNRSFIKDSKTVKLSPLDNAVRTIAAKNDDLIQLΞAFINAALKEKTD YSHYFNDLSRQLAGTVDSPVNGGVGQYRAFFSDSKYQINEESIAKTELLRNAF NDLAIILYRCVNLHGSLIGLSMKSSHQALVELFRKNFQEEIVALRLGEEATIT APSSSRVSIFHNKRANGLMTERANSISNMSGAGSTYSGSRLARSPTNASSVSS NNSSITRSGRASNTSGYPASVIQPGYTGLKGSSLKNGNGSVTSKSINGSGKTN

AINTKW

YMR029C; MPPFKLRSRSNSSSSSNPQTQWYNNKNQNQPSMSEPTYTLPGVINYLTSEFTK 167

EAK97460; LEQFKIVNNLERSEMKFKIKΞLΞGEIKSLTFTNKLQKKTIERLQTENKKLRSR

46438124 LNEEEVEEVIMTPSPEELAKMSKIDLQTIKRTRERLANSMKEIVTLLKPPTLE PSISLAKTSKNTNDLESLLDKPEINKADDFNFNVKPYSFESKDYESPVRNPSS LISQYFNSNTDLKEISKΞKKKAEMENDSIVDDDEILDAELEDVLEKAISETSD SATIVLISTDDDDPLADLNDDDFSLDDSPQERSQINNNNNNNNDDDDLDFEDKLS SFPSLVSPSLVLPSLVPPPLKSPQLQPPQLEPPVLEPQVSSSISSSSKKNKEE EGGYDHLDVYYHDPNTIYLRSMKDTTKKEVKLDMLLDGKLASTQKFEMETSAQ DIADILPIDVPDTLLIVKKNGDVKSMVFELGNGKEHTIMSVKSDFKDIESCGL TEFTVKMDDTYKYYGLCISGKSSSNRKFLSKIYΞLSYDLSNRΆVTSKEIGSYN KKFLTKGKPADEVHFAGWINNAKVDSLVDILEADKDPKSSISGDDLTLLPYEV LYDVDGKTIKLNIVSKQVLEILA

YPR098C; MLCQVGLNVKVPFHFLFYSLTFGGSAFYSFIVSPLVFKKLPREEFSNLQNKVF 168

EAL03384; PTYFTGQTLAPIILGLAQPFAYCPFTLGLLALSSVGGALNYLWLLPVCQKIKE

46444107 DRNKLIADKKDVGADGQPTEELKALNKQFGKYHGISTLVNITSILSLGVYGW LAKGLSKIKF Table 10. DNA sequences encoding fungal cell wall proteins

CCGAGTATTGGTCTCAΆTCCTTTGCTACTACTACTACAGTTACTGCTCCTCCA

GGTGGTACTGACTCAGTAATTATCAGAGAACCTCCAAACCCAACTGTCACCΆC

CACTGAATATTGGTCCCAATCTTACGCAACCACAACTACTGTGACTGCTCCTC

CAGGAGGCACTGACTCAGTAATTATCAGAGAACCACCAAACCACACTGTCACT

ACTACTGAATACTGGTCACAATCATATGCCACCACTACCACTGTAACTGCACC

ACCAGGTGGTACTGACACTGTTATCATTAGAGAGCCACCAAACCACACTGTCA

CTACTACTGAGTATTGGTCTCAATCGTTTGCTACTACCACAACTGTAACTGGT

CCACCAAGTGGCACTGATACTGTTATCATTAGGGAACCACCAAACCCAACTGT

CACCACTACTGAATACTGGTCTCAATCATATGCAACCACTACTACCATTACCG

CTCCACCTGGTGAAACTGATACCGTTCTTATCAGAGAGCCACCAAACCATACT

GTCACTACTACTGAATACTGGTCTCAATCATATGCTACAACCACCACTGTTAC

TGCACCACCTGGTGAAACCGATΆCCGTTCTTATCAGΆGAGCCACCAAACCATA

CTGTCACTACTACTGAATACTGGTCTCAATCATATGCTACAACCACCACTGTT

ACTGCACCACCAGGTGGTACCGATACTGTTATCATTAGAGAGCCACCAAATCC

AACAGTTACTACTACTGAATATTGGTCACAATCATTTGCCACAACCACCACAG

TTACTGCTCCTCCAGGTGGTACTGACACTGTGATTATCTATGAAAGCATGTCA

AGTTCAAAGATTTCTACATCCTCCAATGATATAACCAGTATCATTCCATCATT

TTCCCGTCCTCATTATGTCAACAGCACAACCTCCGATTTGTCAACATTTGAAT

CTTCATCCATGAATACTCCTACTTCTATCAGTAGTGATGGTATGTTGTTGTCT

TCTACAACTTTGGTTACTGAATCAGAAACAACTACAGAACTGATTTGCAGTGA

TGGTAAAGAGTGTTCTAGATTGTCCAGTTCTTCTGGTATTGTCACAAATCCAG

ATAGCAATGAATCCTCAATCGTAACTAGTACTGTTCCTACTGCAAGTACAATG

TCTGATTCACTTTCTTCAΆCTGΆTGGTATTAGTGCTACATCTTCTGATAATGT

TTCAAAATCAGGAGTATCAGTTACAACCGAAACTTCTGTTACAACTATTCAAA

CTACTCCAAACCCATTΆTCATCTTCAGTGACATCATTGACTCΆGTTGTCTTCA

ATTCCAAGTGTTTCAGAAAGTGAAAGTAAAGTTACATTTACAAGCAATGGAGA

CAACCAAAGTGGTACTCATGATTCACAATCTACTTCCACTGAAATTGAAATTG

TAACAΆCCAGTTCTACTAAAGTTTTACCACCTGTCGTTTCTTCTAATACTGAT

TTGACTAGTGAACCAACAAATACCAGAGAACAACCAACTACATTATCAACTAC

TTCAAACTCCATCACTGAAGATATCACCACATCTCAACCTACAGGTGATAATG

GAGACAATACTTCATCAACCAATCCAGTTCCAACTGTGGCAACAAGTACTTTA

GCATCTGCAΆGTGAAGΆAGΆCAACAAAAGCGGTTCTCATGAATCAGCATCCAC

AAGTTTGAAACCAAGTATGGGTGAAAATTCTGGATTAACTACTTCTACTGAAA

TTGAΆGCTACAACAΆCCAGTCCTACAGΆAGCTCCATCACCTGCTGTTTCTTCT

GGTACTGATGTAACTACTGAACCAACTGATACTAGAGAACAACCTACTACATT

ATCAACTACTTCAAAAACAAACΆGTGAACTGGTTGCTACTACΆCAAGCTACTA

ATGAAAATGGTGGTAAATCTCCATCAACTGATTTAACATCAAGCTTGACAACA

GGCACCTCAGCATCTΆCAAGTGCTAATAGCGAACTTGTTACTAGTGGATCTGT

TACTGGTGGAGCTGTTGCCAGTGCTTCAAATGATCAATCACATTCTACTTCTG

TTACCAACAGCAACAGCATTGTATCTAATACCCCACAAACTACATTGAGTCAA

CAAGTTACCTCATCCTCACCTTCAACCAACACATTCATTGCTTCTACATACGA

TGGCTCTGGTTCTATTATCCAACATTCTACTTGGTTGTACGGTTTGATCACAT

TATTGTCCTTGTTCATTTAG

CaO19.9891; ATGCTTTTACAATTTTTGTTGCTAAGCCTCTGTGTATCAGTTGCTACTGCAAA 171

AACQ01000149; AGTTATTACGGGTGTTTTCAATAGTTTTGATTCGTTGACATGGACAAGAGCTG

46434072 GTAATTATGCTTATAAGGGCCCAAATAGACCAACTTGGAATGCTGTTTTGGGC TGGTCTTTAGATGGTACTΆGTGCAAACCCAGGAGACΆCATTCACATTGAATAT GCCATGTGTTTTTAAATTTATTACCGATCAAACATCTGTTGATTTGACTGCTG ACGGTGTTAAATATGCTACATGTCAGTTTTATTCAGGTGAAGAATTTACAACA TTTTCTTCATTAAAATGTΆCTGTGΆGCAATACTTTAACATCATCTATTAAGGC TTTGGGTACGGTTACTTTACCAATTTCATTTAATGTTGGTGGAACAGGTTCAT TGGTTGATTTGGAAAGTTCTAAATGTTTTAAGGCTGGCACCAACACAGTTACT TTTAATGATGGTGATAAAAAAATCTCAATTGACGTTGATTTTGAGAΆAACAAA CGAAGATGCAAGTGGATATTTCATAGCGTCAAGACTTATTCCAAGTATTAACA AAGCTTCAATCACTTATGTGGCACCACAATGTGCAAATGGCTACACATCTGGT GCAATGGGGTTCACAATTGGCAGTGGTGACACTACTATTGACTGTTCAAATGT TCATGTTGGTATTACAAAGGGATTAAATGATTGGAATTTTCCGGTATCGTCTG

ATTCATTAAGTTACAΆTAAAACTTGTTCATCTACAGGTATTTCTATCACΆTAT GAΆAATGTCCCCGCTGGTTATCGTCCATTTTTTGACGTATATACTCTGGTGTC

AGACCAGAACAGACAATTAAAATATACTAATGATTATGCCTGTGTTGGTAGTT

CCTTACAAAGTAΆGCCGTTCAATTTAAGATTGAGAGGATACAATAATAGTGΆA

GCTAATTCTAACGGTTTTGTCATTGTTGCTACAΆCCCGAΆCAGTTACTGACAG

TACTACTGCTGTCΆCTACTTTACCTTTTAATCCAAGTATTGACAAΆΆCCAAAA

CAΆTCGAAATTTTGCAACCTATTCCΆACAACCACTATCACAACTTCATATGTT

GGTGTGACTACTTCCTACCTGACTAAAACTGCACCAATTGGTGAAACΆGCTAC

TGTTATTGTTGATGTGCCATATCATACTACCACAACTGTTACCAGTGAATGGA

CAGGAACAATCACTACCACTACAACTCGTACCAATCCAΆCTGATTCTATAGΆT

ACTGTCGTTGTGCAAGTTCCACTGCCΆAATCCAΆCTGTTAGTACAΆCCGAGTA

TTGGTCTCAGTCATATGCAACCACTACTACCATTACCGCTCCTCCAGGTGGTA

CCGATACTGTGATTATTAGAGAGCCΆCCAAACCACΆCTGTCACTACTACTGAA

TACTGGTCTCAATCATATGCTACΆACCACCACTGTTACTGCTCCTCCAGGTGG

TACTGACTCAGTAATTATCAGAGAACCACCAAATCCAACTGTCACTACAACCG

AGTATTGGTCCCAGTCΆTATGCAACCACTACTACCATTACCGCTCCTCCAGGT

GGTACCGATACTGTGATTATTAGAGAGCCACCAAACCACACTGTCACTACTAC

TGΆATATTGGTCTCAGTCATATGCTACTACTACTACTGTTACTGCTCCTCCAG

GTGGTACTGACTCAGTAATTATCAGAGAACCTCCAAACCCAACTGTCACCACC

ACTGAATATTGGTCCCAΆTCTTACACAACCACAΆCTACTGTGACTGCTCCTCC

AGGTGGTACTGACTCAGTGATTATCAGAGAGCCACCAAACCCAACTGTAACAA

CCACCGAGTΆTTGGTCACAGTCGTACGCAACTACAACTACTGTAACTGCCACT

CCAGGTGGTACTGACACTGTGATTATTAGAGAGCCACCTAATTATACTGTCAC

CACAACTGAATATTGGTCTCAATCGTACGCTACCACCACCACTGTTACTGCCC

CTCCAGGTGGCACTGATACTGTTATTATTAGGGAGCCACCAAATTACACGGTT

ACCACΆACTGAATACTGGTCTCAGTCGTACGCAACTACAACTACTGTAACTGC

TCCTCCAGGTGGTACTGATACCGTTATCATTAGGGAGCCACCAAACTATACTG

TGACAACTACTGAATACTGGTCACAGTCGTACGCAACTACCTCΆACTATCΆCA

GCCCCACCGGGAGGCACTGACACTGTGATTATTAGΆGAGCCACCAAATTACAC

GGTTACTACAACTGΆATATTGGTCCCAΆTCTTATGCTACGACCACCACTGTTA

CTGGTCCACCGGGAGGCACTGACACTGTGATTATTAGAGAACCTCCAAGTCCA

ACAGTTACAACAACCGAGTACTGGTCACAATCTTACGCAACCACAACTACCGT

GACTGCTCCTCCAGGAGGTACCGCTACTGTGATCATAAAAGAGCCΆCCAAATT

ACACGGTCACTACTΆCTGAATACTGGTCACΆATCATATGCTACAACCACTACA

GTCACTGGTCCACCAGGAGGTACCGATACTGTTATTATTAGGGAGCCACCAAA

TCCAACTGTAACCACTACTGAATACTGGTCTCAATCCTTTGCTACTACTACTA

CAGTTACTGCTCCTCCAGGTGGTACTGACTCAGTAATTATCAGAGAACCTCCA

AACCCAACTGTCACCACCACTGAATΆTTGGTCCCAATCTTACGCAACCACAAC

TACTGTGACTGCTCCTCCAGGTGGTACTGACTCAGTGATTATCAGAGAACCTC

CAAACCCAΆCTGTCACCΆCCACTGAATATTGGTCCCAATCTTACACAACCACA

ACTΆCTGTGACTGCTCCTCCAGGTGGTACTGACTCAGTGATTΆTCAGAGAGCC

ACCAAACCCAACTGTAACAACCACCGAGTATTGGTCACAGTCGTACGCAACTA

CAACTACTGTAACTGCCACTCCAGGTGGTACTGACΆCTGTGATTATTAGAGAG

CCACCTAATTATACTGTCACCACAACTGAATATTGGTCTCAATCGTACGCTAC

CACCACCACTGTTACTGCCCCTCCAGGTGGCACTGATACTGTTATTATTAGGG

AGCCACCAAATTACACGGTTΆCCACAACTGAATACTGGTCTCΆGTCGTACGCA

ACTACAACTACTGTAACTGCTCCTCCAGGTGGTACTGATACCGTTATCATTAG

GGAGCCACCAAACCATACTGTGACAACTACTGAATACTGGTCACAGTCGTACA

CTACAACCACCΆCTGTTATTGCCCCACCAGGTGGCACTGATTCGGTTATCATT

AGAGAACCTCCAAATCCAACTGTCACAACCACTGAGTACTGGTCTCAATCTTA

CGCAACTACCACTACCATTACCGCTCCTCCAGGTGAAACCGATACTGTCCTTA

TTAGGGAACCΆCCAAATCACACTGTCACTACTACTGAATACTGGTCACΆATCA

TTTGCTACAACCACΆΆCTGTAACTGCACCACCAGGTGGTACTGACACTGTTAT

CATTAGAGAACCACCAAACCACACTGTCACTACTACTGAGTATTGGTCTCAAT

CTTACGCAACCACTACTACCATTACCGCTCCACCTGGTGAGACCGATACTGTC CTTATTAGAGAACCACCAAACCATACTGTCACTACAACTGAGTATTGGTCTCA

ATCCTATGCAACTACTACCACTATCATCGCACCΆCCAGGTGAAΆCTGATACTG

TTTTAATCAGAGAGCCACCAAACCCAACTGTTACCACCACCGAATACTGGTCT

CAATCCTATACCACTGCTACTACCGTTACTGCACCACCAGGTGGAACTGATAC

TGTGATTATTTΆTGACACCATGTCAAGTTCAGAAATTTCTTCATTTTCTCGTC

CTCATTACACCAACCATACAACTTTGTGGTCTACAACTTGGGTTATTGAAACA

AAAACAATTACAGAAACTAGCTGTGAAGGTGATAAAGGTTGTTCTTGGGTTTC

TGTTTCTACTCGTATTGTCACAATTCCTAATAATATCGAAACTCCTATGGTTA

CTAATACTGTTGATACTACAACCACAGΆATCCACTTTACAATCCCCATCTGGT

ATTTTTTCAGAGTCAGGAGTATCTGTTGAAACAGAATCTTCTACTTTTACTAC

TGCTCAAACAAATCCAAGTGTTCCAACAACTGAAAGTGAGGTTGTATTTACTA

CTAAAGGAAACAACGGAAATGGTCCTTATGAATCACCATCTACTAATGTGAAA

TCAAGTATGGATGAAAATTCTGAΆTTTACTACTTCCACAGCTGCTTCCACTTC

TACTGATATTGAAAATGAAACCATAGCAACAACCGGTTCCGTGGAAGCTTCAT

CGCCTATCATTTCTTCTAGTGCTGATGAAACTACTACTGTTACTACTACTGCT

GAATCAACCAGTGTCATTGAACAACAAACCAATAATAATGGTGGTGGTAATGC

TCCATCTGCAACTTCAACTTCAACTTCATCTCCATCTACAACTACAΆCTGCTA

ATAATGACTCTGTTATTACTAGTACAACATCAATCAACCAATCTCAATCGCAA

TCCAATTCTGATACCCAACAAACTACATTGAGTCAACAAATGACTTCATCTTT

GGTTAGTTTACATATGCTTACTACATTTGATGGATCTGGTTCTGTTATTCAAC

ATTCTACTTGGTTATGTGGTTTGATCACATTATTATCCTTATTTATTTAA

ALS3-3; ATGCTTTTACAATTTTTGTTGCTAAGCCTCTGTGTATCAGTTGCTACTGCAAA 172 not avail; AGTTATTACGGGTGTTTTCAATAGTTTTGATTCGTTGACATGGACAAGAGCTG not avail GTAATTATGCTTATAAGGGCCCAAATAGACCAACTTGGAATGCTGTTTTGGGC

TGGTCTTTAGATGGTACTAGTGCAAACCCAGGAGACACATTCACATTGAATAT

GCCATGTGTTTTTAAATTTATTACCGATCAAACATCTGTTGATTTGACTGCTG

ACGGTGTTAAATATGCTACATGTCAGTTTTATTCAGGTGAAGAATTTACAACA

TTTTCTTCATTAAAATGTACTGTGAGCAATACTTTAΆCATCATCTATTAΆGGC

TTTGGGTACGGTTACTTTACCAATTTCATTTAATGTTGGTGGAACAGGTTCAT

TGGTTGATTTGGAAAGTTCTAAATGTTTTAAGGCTGGCACCAACACAGTTACT

TTTAATGATGGTGATAAAAAAATCTCAATTGACGTTGATTTTGAGAAAACAAA

CGAAGATGCAAGTGGATATTTCATAGCGTCAAGACTTATTCCAAGTATTAACA

AΆGCTTCAATCACTTATGTGGCACCACAATGTGCAAATGGCTACACATCTGGT

GCAATGGGGTTCACAATTGGCAGTGGTGACACTACTATTGACTGTTCAAATGT

TCATGTTGGTATTACAAAGGGATTAAATGATTGGAATTTTCCGGTATCGTCTG

ATTCATTAAGTTACAATAAAACTTGTTCATCTACAGGTATTTCTATCACATAT

GAAAATGTCCCCGCTGGTTATCGTCCATTTTTTGACGTATATACTCTGGTGTC

AGACCAGAACAGACAATTAAAATATACTAATGATTATGCCTGTGTTGGTAGTT

CCTTACAAAGTAAGCCGTTCAATTTAAGATTGAGAGGATACAATAATAGTGAA

GCTAATTCTAACGGTTTTGTCATTGTTGCTACAACCCGAACΆGTTACTGACAG

TACTACTGCTGTCACTACTTTACCTTTTAATCCAAGTATTGACAAAACCAAAA

CAATCGAAATTTTGCAACCTATTCCAACAACCACTATCACAACTTCATATGTT

GGTGTGACTACTTCCTACCTGACTAAAACTGCACCAATTGGTGAAACAGCTAC

TGTTATTGTTGATGTGCCATATCATACTACCACAACTGTTACCAGTGAATGGA

CAGGAACAATCΆCTACCACTACAACTCGTACCAATCCAΆCTGATTCTATAGAT

ACTGTCGTTGTGCAAGTTCCACTGCCAAATCCAΆCTGTTAGTACAACCGAGTA

TTGGTCTCAGTCATATGCAACCACTACTACCATTACCGCTCCTCCAGGTGGTA

CCGATACTGTGATTATTAGAGAGCCACCAAACCACACTGTCACTACTACTGAA

TACTGGTCTCAATCΆTATGCTACAACCACCACTGTTACTGCTCCTCCAGGTGG

TACTGACTCAGTAATTATCAGAGAΆCCACCAAATCCAACTGTCACTACAACCG

AGTATTGGTCCCAGTCATATGCAACCACTACTACCATTACCGCTCCTCCAGGT

GGTACCGATACTGTGATTATTAGAGAGCCACCAΆACCΆCACTGTCACTACTAC

TGAΆTATTGGTCTCAGTCATATGCTACTACTACTACTGTTACTGCTCCTCCAG

GTGGTACTGACTCAGTAΆTTATCAGΆGAACCTCCAAACCCAACTGTCACCACC

ACTGAATATTGGTCCCAATCTTACACAACCACAACTACTGTGACTGCTCCTCC

AGGTGGTACTGACTCAGTGATTATCAGAGAGCCACCAAACCCAACTGTAACAA CCACCGAGTATTGGTCACAGTCGTACGCAACTACAACTΆCTGTAACTGCCACT

CCAGGTGGTACTGACACTGTGATTATTAGAGAGCCACCTAATTATACTGTCAC

CACAACTGAATATTGGTCTCAATCGTACGCTΆCCACCACCACTGTTACTGCCC

CTCCAGGTGGCACTGATACTGTTΆTTATTAGGGΆGCCACCΆAATTACACGGTT

ACCACAACTGAATACTGGTCTCAGTCGTACGCAACTACAACTACTGTAACTGC

TCCTCCAGGTGGTACTGATACCGTTATCATTAGGGAGCCACCAAACTATACTG

TGACAACTACTGAATACTGGTCACAGTCGTACGCAACTACCTCAΆCTATCACA

GCCCCACCGGGAGGCACTGACACTGTGATTATTAGAGAGCCACCAAATTACAC

GGTTACTACAACTGAATATTGGTCCCAATCTTATGCTACGACCACCACTGTTA

CTGGTCCACCGGGAGGCACTGACACTGTGATTATTAGAGAACCTCCAAGTCCA

ACAGTTACAACAACCGAGTACTGGTCACAATCTTACGCAΆCCACAΆCTACCGT

GACTGCTCCTCCAGGAGGTACCGCTACTGTGATCATAAAAGAGCCACCAAATT

ACACGGTCACTACTACTGAATACTGGTCACAATCATATGCTACAACCACTACA

GTCACTGGTCCACCAGGAGGTACCGATACTGTTATTATTAGGGAGCCACCAAA

TCCAACTGTAACCACTACTGAΆTACTGGTCTCAATCCTTTGCTACTACTACTA

CAGTTACTGCTCCTCCAGGTGGTACTGACTCAGTAATTATCAGAGAΆCCTCCA

AACCCAACTGTCACCACCACTGAATATTGGTCCCAATCTTACGCAACCACAAC

TACTGTGACTGCTCCTCCAGGTGGTACTGACTCAGTGATTATCAGAGAACCTC

CAAACCCAACTGTCACCACCACTGAATATTGGTCCCAATCTTACACAACCACA

ACTACTGTGACTGCTCCTCCAGGTGGTACTGACTCAGTGATTATCAGAGAGCC

ACCAAACCCAΆCTGTAACAACCACCGAGTATTGGTCACAGTCGTACGCAACTA

CAACTACTGTAACTGCCACTCCAGGTGGTACTGACACTGTGATTATTAGAGAG

CCACCTAATTATACTGTCACCACAACTGAATATTGGTCTCAATCGTACGCTAC

CACCACCACTGTTACTGCCCCTCCAGGTGGCACTGATACTGTTATTATTAGGG

AGCCΆCCAAΆTTACACGGTTACCACAACTGAATACTGGTCTCAGTCGTACGCA

ACTACAACTACTGTAACTGCTCCTCCAGGTGGTACTGATACCGTTATCATTAG

GGAGCCACCAAACCATACTGTGACAACTACTGAATACTGGTCACAGTCGTACA

CTACΆACCACCΆCTGTTATTGCCCCACCAGGTGGCACTGΆTTCGGTTATCATT

AGAGAACCTCCAAATCCAACTGTCACAACCACTGAGTACTGGTCTCAATCTTA

CGCAACTACCACTACCATTACCGCTCCTCCAGGTGAAACCGATACTGTCCTTA

TTAGGGAACCACCAAATCACACTGTCACTACTACTGAATACTGGTCACAATCA

TTTGCTACAACCACAACTGTAACTGCACCACCAGGTGGTACTGACACTGTTAT

CATTAGAGAΆCCΆCCAAΆCCACACTGTCACTACTACTGAGTATTGGTCTCAAT

CTTACGCAACCACTACTACCATTACCGCTCCACCTGGTGAGACCGATACTGTC

CTTATTAGAGAACCACCAAACCATACTGTCACTACAACTGAGTATTGGTCTCA

ATCCTATGCAACTACTACCACTATCATCGCACCACCAGGTGAAACTGATACTG

TTTTAATCAGAGAGCCACCAAACCCAACTGTTACCACCACCGAATACTGGTCT

CAATCCTATΆCCACTGCTACTACCGTTACTGCACCACCAGGTGGΆACTGATAC

TGTGATTATTTATGACACCATGTCAAGTTCAGAAATTTCTTCATTTTCTCGTC

CTCATTACACCAACCATACAACTTTGTGGTCTACAACTTGGGTTATTGAAACA

AAAACAATTACAGAAΆCTAGCTGTGAAGGTGATAAAGGTTGTTCTTGGGTTTC

TGTTTCTACTCGTATTGTCACAATTCCTAATAATATCGAAACTCCTATGGTTA

CTAΆTACTGTTGATACTACAACCACAGAATCCACTTTACΆATCCCCATCTGGT

ATTTTTTCAGAGTCAGGAGTATCTGTTGAAACAGAATCTTCTACTTTTACTAC

TGCTCAAACAAATCCAAGTGTTCCAACAACTGAAAGTGAGGTTGTATTTACTA

CTAAAGGAAACAACGGAAATGGTCCTTATGAATCACCATCTACTAATGTGAAA

TCAAGTATGGATGAAAATTCTGAATTTACTACTTCCACAGCTGCTTCCACTTC

TACTGATATTGAAAATGAAACCATAGCAACAACCGGTTCCGTGGAAGCTTCΆT

CGCCTATCATTTCTTCTAGTGCTGATGAAACTACTACTGTTACTACTACTGCT

GAATCAACCAGTGTCATTGAACAACAAACCAATAATAATGGTGGTGGTAATGC

TCCATCTGCAACTTCAACTTCATCTCCATCTACAACTACAACTGCTAATAGTG

ACTCTGTTATTACTΆGTACAΆCATCAACCAACCAATCTCAATCGCAATCCAAT

TCTGATACCCAACAAACTACATTGAGTCAACAAATGACTTCATCTTTAGTTAG

TTTACATATGCTTACTACATTTGACGGATCTGGTTCTGTTATTCAACATTCTA

CTTGGTTATGTGGTTTGATCACATTATTATCCTTATTTATTTAA

ALS8; ATGCTACAACAATATACATTGTTACTCATATATTTGTCGGTTGCGACTGCAAA 173 AACQ01000270 ; GACAATCACTGGTGTTTTCAACAGTTTTAATTCATTGACTTGGTCTAATGCTG 46431624 CTACGTATAATTATAAGGGACCAGGAACCCCAACTTGGAATGCTGTTTTGGGT

TGGTCTTTAGATGGTACTAGTGCAΆGTCCGGGΆGATACATTCACATTGAATAT

GCCATGTGTGTTTAAATTTACTACTTCTCAAACATCTGTTGATTTGACTGCTC

ATGGTGTTAAATATGCTACATGTCAATTTCAGGCAGGTGAAGAATTTATGACC

TTTTCTΆCATTAACATGTACTGTGAGCAATACTTTGACTCCATCTATTAAGGC

TTTGGGTACTGTCACTTTACCACTTGCATTCAATGTAGGTGGAACTGGTTCTT

CTGTTGATTTGGAAGATTCTAAATGTTTTACTGCTGGTACTAACACAGTTACA

TTTAATGATGGTGGCAAGAAAATCTCAATTAATGTTGATTTTGAAAGGTCAAA

TGTCGATCCAAAAGGGTACTTAACTGATTCCAGAGTTATACCAAGTCTCAACA

AAGTGTCAACTCTTTTTGTTGCACCACAATGTGCAAATGGTTACACATCTGGT

ACAATGGGATTCGCTAACACTTATGGTGATGTTCAAATTGACTGTTCAAATAT

TCATGTTGGTATTACAAAΆGGATTGAATGATTGGAATTATCCGGTTTCATCTG

AATCATTTAGTTACΆCCAAAACTTGTTCATCTAATGGTATCTTTATCACATAT

AAAAACGTTCCTGCCGGTTATCGTCCATTTGTTGACGCTTATATTTCTGCTAC

AGATGTTAATTCGTACACCTTGTCGTATGCTAΆTGΆATATACTTGTGCTGGTG

GTTATTGGCAΆCGTGCACCTTTCACATTAAGATGGACTGGATACAGAAATAGT

GATGCTGGATCTAACGGTATTGTTATTGTGGCTΆCTACCAGΆACAGTTACAGA

CAGTACTACCGCCGTGACCACCTTACCATTCGATCCTAACCGCGACAAAACTA

AGACAATTGAAATTTTGAAACCTATTCCAACAACTACAATCACAACATCATAT

GTTGGTGTGACTACTTCCTACCTGACCAAΆACTGCACCAATTGGGGAAACTGC

TACTGTTATTGTTGATATTCCATATCACACTACCACTACTGTTACCAGTAAAT

GGACAGGAACAATTACTTCCACCACAACACATACTAATCCAACTGACTCAATA

GACACTGTCATTGTACAAGTTCCACTGCCAAACCCAACTGTTACTACCACTGA

ATATTGGTCTCAATCATTTGCTACCACCACCACCATTACTGGACCACCAGGAA

ACACTGATACTGTTTTAATCAGAGAGCCACCAAACCATACTGTCACTACAACC

GAGTATTGGTCAGAΆTCTTACACTACTACTAGTACTTTCACTGCTCCTCCAGG

TGGAACTGATTCAGTTATTATCAAGGAACCTCCAAATCCAACTGTTACAACTA

CCGAGTACTGGTCΆGAATCTTACACTACCACTACTΆCTGTCACCGCTCCACCA

GGAGGTACTGATACCGTGATTATCAGAGAACCACCAAACCATACTGTAACCAC

AACTGAATACTGGTCΆCΆΆTCTTACACTACAACCACCΆCTGTTATTGCCCCAC

CAGGTGGCACTGATTCGGTTATCATTAGAGAACCTCCAAΆTCCAACTGTCACA

ACCACTGAGTACTGGTCTCAATCTTACGCAACTACCACTACCATTACCGCTCC

TCCAGGTGAAACCGΆTACTGTCCTTATTΆGGGΆACCACCAAATCACACTGTCA

CTACTACTGAATACTGGTCTCAATCTTACGCAACTACCACTACCATTACCGCT

CCTCCAGGTGAAΆCCGATACTGTCCTTATTAGGGAACCΆCCAAATCACACTGT

CACCACTACTGAATACTGGTCACAATCT_TACACTACAACCACCACTGTTATTG

CCCCACCAGGTGGCACTGATTCAGTTATCATCAΆGGAACCACCAΆACCCAACT

GTCACTACAACTGAATATTGGTCTCAATCTTACGCAACTACCACTACCATTAC

CGCTCCTCCAGGTGAGACCGATACTGTCCTTATTAGAGAACCACCAAACCATA

CTGTAACCACAACTGAGTATTGGTCTCAATCCTATGCAACTACTACTACAATC

ACTGC_TCCTCCAGGTGAAACCGATACCGTTC_TTA_TTAGGGAACCACCAAATCA

CACAGTTACTACTACTGAΆTACTGGTCACAATCATTTGCTACAACCACAACTG

TAΆCTGCACCACCAGGTGGTACTGACACTGTTATCATTAGAGAACCACCAAAT

CACACTGTCACTACTACTGAATACTGGTCACAATCATTTGCTACAACCACAAC

TGTAACTGCACCACCAGGTGGTACTGACACTGTT_TTAATCAGAGAGCCACCAA

ACCCAACTGTTACCACCACCGAATACTGGTCTCAACCTTACACAACCACCACT

ACAGTTATTGCACCACCAGGTGGAACTGATACTGTGATTATTTATGACACCAT

GTCAAGTTCAGAAATTTCTTCATTTTCTCGTCCTCATTACACCAACCATAC

ALS3; ATGCTACAACAATATACATTGTTACTCATATATTTGTCGGTTGCGACTGCAAA 174

AY223552; GACAATCACTGGTGTTTTCAACAGTT_TTA_ATTCAT_TGACT_TGGTCTAATGCTG

29373982 CTACGTATAATTATAAGGGACCAGGAACCCCAACTTGGAATGCTGTTTTGGGT TGGTCTTTAGATGGTACTAGTGCAAGTCCGGGAGATACATTCACATTGAATAT GCCATGTGTGTTTAAATTTACTACTTC_TC_AA_AC_ATC_TGTTGATTTGACTGCTC ATGGTGTTAAATATGCTACATGTCAΆTTTCAGGCAGGTGAΆGAATTTATGACC TTTTCTACATTAACATGTACTGTGAGCAATACTTTGACTCCATCTATTAAGGC TTTGGGTACTGTCACTTTACCACTTGCATTCAATGTAGGTGGAACTGGTTCTT

CTGTTGATTTGGAAGATTCTAAATGTTTTACTGCTGGTACTAACACAGTTACA TTTAATGATGGTGGCAAGAAAATCTCAATTAATGTTGATTTTGAΆΆGGTCAAA

TGTCGATCCAAAAGGGTACTTAACTGATTCCAGAGTTATACCAAGTCTCAACA

AAGTGTCAΆCTCTTTTTGTTGCACCACAATGTGCAAATGGTTACΆCATCTGGT

ACAATGGGATTCGCTAΆCACTTATGGTGATGTTCAAATTGACTGTTCAAΆTAT

TCATGTTGGTATTACAΆAAGGATTGAΆTGATTGGAATTΆTCCGGTTTCATCTG

AATCATTTAGTTACACCAAAACTTGTTCATCTAATGGTATCTTTATCACATAT

AAAAACGTTCCTGCCGGTTATCGTCCATTTGTTGACGCTTATATTTCTGCTAC

AGATGTTAATTCGTΆCACCTTGTCGTATGCTAATGAATATACTTGTGCTGGTG

GTTATTGGCAACGTGCACCTTTCACATTAAGATGGACTGGATACAGAAATAGT

GATGCTGGATCTAΆCGGTATTGTTATTGTGGCTΆCTACCAGAACΆGTTACAGA

CAGTACTACCGCCGTGACCACCTTACCATTCGATCCTAACCGCGACAAAACTA

AGACAATTGAAATTTTGAAACCTATTCCAACAACTACAATCACAACATCATAT

GTTGGTGTGACTACTTCCTACCTGACCAAAACTGCACCAATTGGGGAAACTGC

TACTGTTATTGTTGATΆTTCCATATCACACTACCACTACTGTTACCAGTAAAT

GGACAGGAACAATTACTTCCACCACAACACATACTAATCCAACTGACTCAATA

GACACTGTCATTGTACAAGTTCCACTGCCAAACCCAACTGTTACTACCACTGA

ATATTGGTCTCAATCATTTGCTACCACCACCACCATTACTGGΆCCACCAGGΆA

ACACTGATACTGTTTTAATCAGAGAGCCACCAAACCATACTGTCACTACAACC

GAGTATTGGTCAGAATCTTACACTACTACTAGTACTTTCACTGCTCCTCCAGG

TGGAACTGATTCAGTTATTATCAAGGAACCTCCAAATCCAACTGTTACAACTA

CCGAGTACTGGTCAGAΆTCTTACACTACCΆCTACTACTGTCACCGCTCCACCA

GGAGGTACTGATACCGTGATTATCAGAGAACCACCAAACCATACTGTAACCAC

AACTGAATACTGGTCACAATCTTACACTACAACCACCACTGTTATTGCCCCAC

CAGGTGGCACTGATTCGGTTATCATTAGAGAACCTCCAAΆTCCAACTGTCACA

ACCACTGAGTACTGGTCTCAATCTTACGCAACTACCACTACCATTACCGCTCC

TCCAGGTGAAACCGATACTGTCCTTATTAGGGAACCACCAAATCACACTGTCA

CTACTACTGAATACTGGTCTCAATCTTACGCAACTACCACTACCATTACCGCT

CCTCCAGGTGAAACCGATACTGTCCTTATTAGGGAACCACCAAATCACACTGT

CACCACTACTGAATACTGGTCACAATCTTACACTACAACCACCACTGTTATTG

CCCCACCAGGTGAAACTGATTCAGTTATCATCAAGGAACCACCAAACCCAACT

GTCACTACAACTGAATATTGGTCTCAATCTTACGCAACTACCACTACCATTAC

CGCTCCTCCAGGTGAGACCGATACTGTCCTTATTAGAGAACCACCAAACCATA

CTGTAACCACAACTGAGTATTGGTCTCAATCCTATGCAACTACTACTACAATC

ACTGCTCCTCCAGGTGAAACCGATACCGTTCTTATTAGGGAACCACCAAATCA

CACAGTTACTACTACTGAATACTGGTCACAATCATTTGCTACAACCACAACTG

TAACTGCACCACCAGGTGGTACTGACACTGTTATCATTAGAGAACCACCAAAT

CACACTGTCACTACTACTGAATACTGGTCACAATCATTTGCTACAACCACAAC

TGTAACTGCACCACCAGGTGGTACTGACACTGTTTTAATCAGAGAGCCACCAA

ACCCAACTGTTACCACCACCGAATACTGGTCTCAACCTTACACAACCACCACT

ACAGTTATTGCACCACCAGGTGGAACTGATACTGTGATTATTTATGACACCAT

GTCAAGTTCAGAAATTTCTTCATTTTCTCGTCCTCATTACACCAACCATACAA

CTTTGTGGTCTACAACTTGGGTTATTGAAACAAAAACAATTACAGAAACTAGC

TGTGAAGGTGATAAAGGTTGTTCTTGGGTTTCTGTTTCTACTCGTATTGTCAC

AATTCCTAATAATATCGAAACTCCTATGGTTACTAATACTGTTGATTCTACAA

CCACAGAATCCACTTCACAATCCCCATCTGGTATTTTTTCAGΆGTCAGGAGTA

TCTGTTGAAACAGAATCTTCTACTGTTACTACTGCTCAAACAAΆTCCAAGTGT

TCCAACAACTGAAAGTGAGGTTGTATTTACTACTAAAGGAAACAΆCGGAAATG

GTCCTTATGAATCACCATCTACTAATGTGAAATCAAGTATGGATGAAAATTCT

GAATTTACTACTTCCACAGCTGCTTCCACTTCTACTGATATTGAAAATGAAAC

CATAGCAΆCAACCGGTTCCGTGGAAGCTTCATCGCCTATCATTTCTTCTAGTG

CTGATGAAΆCTACTACTGTTACTACTACTGCTGAATCAACCΆGTGTCATTGAA

CAACCAACAAATAATAATGGTGGTGGTAATGCTCCATCTGCAACTTCAACTTC

ATCTCCATCTACAACTACAACTGCTAATAGTGACTCTGTTATTACTAGTACAA

CATCAACCAACCAATCTCAATCGCAATCCAATTCTGATACCCAACAAACTACA

TATTTTGTGACTATATCCTCCTTTTCGGTAATAGTACGAGAGCTCAGTGGCAA ACTTTTCGTCGTGGTTTCTTCTTCAAGTTCATATTCACTATCTGAGTCAGAAG AAGTATTGAGATGTΆTATCTTCTACTCCTTGCΆAAATTTCTTCTGAAGACATT ATTGATΆTTCTGTCCGTTAGATTCCTGATGAGGTTGCCAAAΆTTTTTTTTTTA

A

ECEl; ATGAAATTCTCCAAAATTGCCTGTGCTACTGTTTTTGCTTTATCTTCTCAAGC 179

L17087; TGCCATCATCCACCATGCTCCAGAATTCAACATGAAGAGAGATGTTGCTCCAG

311084 CTGCCCCΆGCTGCTCCAGCTGACCAAGCACCTACTGTTCCTGCACCTCAAGAA

TTCAATACTGCTΆTTACCAΆAAGAAGTATTATTGGΆATTATTATGGGTATTCT

TGGCAACATTCCACAAGTAATCCAAATCATCATGAGTATTGTCAAAGCTTTCA

AΆGGTAACAΆGAGAGAAGATATTGATTCTGTTGTTGCTGGTATCATTGCTGAT

ATGCCATTTGTTGTCAGAGCTGTTGACACAGCCATGACTTCTGTTGCTTCTAC

CAAGAGAGATGGΆGCTAATGATGACGTTGCTAΆTGCCGTCGTCAGATTGCCAG

AAATTGTTGCTCGTGTTGCCACTGGTGTTCAACAATCCATCGAAAΆTGCCAAG

AGAGATGGCGTTCCAGATGTTGGCCTTAATCTTGTTGCTAATGCTCCAAGACT

TATCTCTAACGTTTTTGATGGCGTCCTGGAAACTGTTCAACAAGCTAAGAGAG

ATGGTCTTGAAGATTTTCTTGATGAACTTCTTCAAAGACTCCCACAACTCATT

ACTAGATCAGCTGAATCTGCTTTGAAAGACAGTCAACCAGTTAAAAGAGATGC

CGGCTCAGTAGCACTTAGCAATTTAATCAAAAAGAGCATTGAAACTGTCGGTA

TTGAAAATGCTGCTCAAATTGTTTCAGAAAGAGATATTTCTTCTTTGATTGAA

GAΆTATTTCGGAAAAGCTTAA

ECM17; ATGACGATGACGACACATTTCTTATACGACAGAATACGCGGATGTTTCCTTTC 180

AACQOIOOOIIO; AAGTCTTGTAGTTGGGCATGTAACTTTCTTCGTTTGGTTTCCTGGTCAACCAA

46435633 CTCGGTTTTCATTCGACCAACTTCAAACTGTAACCGATGCATTCAAATTGGAT

TCTTCCAATTTAAGAAAGCAGTTATCAGACTTTTTAGAAAGAGAAAACAAATT

GACTTTGTTGGCATCTAAGGACCCATTGTTGTCTAGAAACTTGACTGCTAATG

CTAACACCGAGGCAAAAACCAAACAATCTAAGATTGCAGACGAATCATTCGCC

CAATTGTTACAAGGGTTATCCGGTCCACCTTTGACTGTTGCATTTGCTTCTGA

TGGGGGAAATGCAGAAGCCGTTGCTAAAAΆAGTTAATAGACAAGCTTTGGGTA

GΆGGTTTGAAGTCTGTTGTTTTACAAATGGATGΆCTTGTCAGTTGAAGACTTG

CCTACTGAAACTAATGTTGTTTTTATAΆCTTCAACATCGGGACAAGGGGAΆTT

TCCTACTAATGGTAAACAATTCTGGGACGGTGTTAAAAACACCACAGATTTGG

ATTTATCTGGTATCAGGTTTTCTGTTTTTGGTTTAGGTGACTCCCAGTACTGG

CCAAGAAAAGAAGACAAACATTACTATAACAAACCTGCCAAGGACTTGTTTGC

CΆAGTTAAAACTTTATGGTGGTGTTGAATTGGCAGATATTGGATTAGGTGACG

ACCAAGATGCAGATGGGTTTTCTACTGGTTTCAACGAATGGATTCCAAAGATC

TGGGCCGCATTAGGTGTTGACAATGTTGAAGGTGTTGAAGAACCAAAACCAAT

TACAAATGAAGATATGAAGATTGGTTCAGATTATCTTAGAGGTACGATTGTTG

AAGGATTAAACGATCAATCCACTGGTGCCATTTCTGCGGTTGATCAACAGTTG

ΆCAAAATTCCATGGTATCTATATGCAAGATGATCGTGATATTAGAGATGAGCG

TAAAGCTCAAGGTCTCGAACCAGCTTACACTTTTATGGTGCGTGTTCGTTTAC

CAGGTGGTATTGCTACTCCAGACCAATACTTGAAAATGGACGAGTTGGCTGAT

GAAAGAGGTAATGGTACGTTGAAATTGACCACCAGGGCTACTTTCCAATTGCA

TGGTGTGGTCAAGCACGACTTGAAACCAGCAATCAGAGGCATGAACTCAGCAT

TGATGGATΆCATTGGCTGCTTGTGGGGATGTTAACAGAAATGTTATGGTTTCA

GCTTTACCACΆTAATGCTAAGGTTCATGGTCAAGTTTCTCAAATCGGGGCTTT

GATTTCTGAATTTTTGTTACCAAΆGACAACAGCATATCATGAAATTTGGTTAC

AΆGGTGATGATGCTGGTGATAAΆCCTGGCTACΆGAGAΆGCTTGGGAAAACCGT

AΆAGAAGGACCAACTAΆAAAGAAAACCTTGGTTGCTGGTAATGTCTTGGCTGA

TGTGGAACCACAATATGGAGTCACATATTTACCTAGAAAGTTCAAGATTGTTA

TAACAGTTCCACCATACAATGATGTTGATGTTTATGCCCATGATGTGGGTTTG

ATAGCTATTGTTGAAGACAATGAAGTGGTTGGTTTTAΆCGTTTTΆGCTGGTGG

TGGTATGGGTTCTACACATAATAATAΆAAAGACATATCCTAGAACTGGGTCTA

TGTTGGGTTATGTATCCAAAGACCAAGTTCACATTGCTTGTGAAAAGATCATG

TTGGTGCAGAGAGACTTTGGTGATAGAACAAATAGAΆAGCATGCTAGATTGAA

GTATACCATTGATGACCTTGGTGTTGATGTCTTTAAAGCAAAAGTTGAGGAAT TGTTGGGCTATAAATTTGACGAGCCAAGACCATTCAAGATTGAATCAAACATT GACTATTTTGGCTGGTGCAAGGATGAATTAGGATACAΆCCATTTCACTGCATT CATCGAAAATGGTAGAATTGAAAATACCCCAGAATTGCCGCAGAAAACTGGTT TGCGTAAGATCGCTGAATTCTTGAΆGTCAGGAAΆTAGΆTCAGGAGAATTCAGA TTGACTGGTAACCAGCATATTCTTATATCCAATGTTTCTGATCAAGATTTGGA TGAAGTGAΆAAAATTGTTAGCTCAGTΆTAAATTGGACAATACTGACTTTTCTG CTTTAAGAAAATCTTCTGCAGCATGTGTTGCCTTCCCAACATGTGGTTTAGCT ATGGCCGΆATCTGAAAGATACTTGCCGGTTTTGATTACCAΆGTTGGAAGAAGC TTTAGAAGAATATGGTTTGAGACATGACTCGATAGTGATGAGAATGACTGGTT GTCCAAΆTGGTTGTGCTAGGCCTTGGGTTGCTGAAGTTGCATTGGTTGGTAAA GCATATGGGGCATACAATTTAATGTTGGGAGGTGGTCATCATGGTCAΆAGATT GAATAAGATTTATAGATATTCCATCAAAGAAGATGAGATTTTGGACATTTTGA AΆCCTTTATTCΆAAAGATGGAGCTTGGAAΆGAAACGAAAACGAGCCATTTGGT GACTGGTGTATTAGAGCAGGAATCATTGCAGAAACTΆCAGAAGGGAΆATATTT CCATGATGACATTCCTGAAGACGCATAA

FET31; ATGCGAACATTTCTATCATCATTCATTATTTTGACTACATTTTTAGCTTCATT 181

Y09329; GATAGCTGCTGAAACTCACACATGGTATTTCAAAACTGGTTGGGTAGACGCAA

1684655 ATCCTGATGGGGTTTATCCCCGTAAAATGATTGGGTTCAATGATTCTTGGCCA

TTACCCACTTTGAGAGTTAAAAAGGGCGACAGAGTTCAATTGTATTTGATTAA

TGGATTTGATAACTTAAATACTACTTTACATTTTCATGGATTATTTGTTCGTG

GTGCTAACCAAATGGATGGGCCAGAGATGGTTACCCΆGTGTCCTATCCCACCT

GGTGAAACATΆCTTGTACAACTTCACTGTTACTGATCAAGTGGGAACTTATTG

GTATCATAGCCATACAGGGGGTCAGTATGGAGACGGTATGAGAGGTGTCTTTA

TTATTGAAGATGATGATTTCCCGTATCACTACGATGΆAGAΆGTTGTTTTAACT

TTAAGTGACCATTACCACAAATATTCAGGTGACATAGGGCCTGCCTTTTTAAC

CAGATTTAATCCGACAGGAGCAGAΆCCGATCCCTCAGAACTTTTTGTTCAATG

AAACAAGAAATGCCACTTGGAAGGTCGAACCTGGAAΆAACTTACTTTGTTAGG

ATTCTTAATGTTGGTGGTTTTGTATCACAGTACTTGTGGATGGAAGATCATGA

ATTTACTATTGTTGAGATCGATGGCGTTTACGTTGAAAAAAACACCACTGATT

TGATTTATATCACAGTTGCTCAAAGATΆTGGGGTTTTAATAACCACAAAAAΆT

TCAACCGATAAGAACTATGTATTCATGAATGGTGTTGATACTACCATGTTGGA

TTCAGTTCCTGCTGATTTGCAΆGTCAATGGGACCAATTATATTGTTTATAATG

AAΆGCTCCGCCTTACCGGΆTGCTTACGATATCGATTCGTATGATGΆTGCCTTG

GATGATTTCTACTTGAAACCCTTGAGTAAACAAAAGTTGATGGATGATGCTGA

TTACACTATTACCGTTGATGTTCAAATGAATGTCTTGAATGATGGGATCAΆTT

ATGCTTTTTTCAACAATATTAGTTACAAΆGCACCAAAAGTTCCAACCTTACTA

ACTGTTTTAAGTGCTGGCGAAGCTGCAACAAACGAΆTTGATTTATGGTACCAA

TACCAATAGTTTTGTATTACAAGGTGGAGATATTGTTGATATTGTGCTAAATA

ATTTTGATACTGGTAAACATCCATTCCATTTACACGGTCACGTTTTCCAGTTG

ATTGAGAGACACGAAGCTATAGGTAGCΆAΆGΆAAGTGCΆGTTACATTCAATGT

CΆGCGΆTCATGCTGAATGGCCCGAGTATCCAΆTGATTCGTGACACCGTTTACG

TTAAACCTCATTCTTATΆTGGTTTTAAGATTCAAAGCTGACAΆCCCCGTGGTT

TGGTTTTTCCATTGTCACGTCGACTGGCATTTAGAACAAGGTTTGGCTGTTGT

TTTGATCGAAGATCCTCAAGCCATTCAAAAGAATGAAAAAATTACTGAGAATC

ATAAACGTATCTGTGAAAAAGTTGGTGTTCCATGGGAAGGTAATGCTGCTGCC

AACAGCAΆTGATTATTTGGACTTGAAGGGTGAAAATGTTCAAGTAAAGAGATT

ACCAACAGGATTTACCACCAAAGGAATCGTAGCATTAGTGTTTTCATGTGTTG

CTGCGTTCTTAGGCTTATTCTCATTTTCTTTCTATGGTATGAATGACATTGCT

CΆTGTTGAAGACΆAAGTAGCCAGAGATTTGGATATTGACTTGGAAGCAGAGAA

TGAGGACGAAGAAGAAGCAGTTGTTTTGAACCAGAATTCATCTTCTTCAGACA

GCAACTCTAAGCCACATTAA

FRE5; ATGGCTATTCCATTTGATCAΆCAGTTTTTTGTGGAAAΆGGATAGAAΆTAΆTAA 182

AACQ01000129; ATATGAGTGGTTGATATTTGTATTGACGTTCATTGTGTTAGCTGGACATGGGA

46434795 TACTTTTTTATTGGATTCCACGATACTTGCGAGTCAATAACAAACGCAACAAC TATTTTAGACTACTTAΆAGTGTGGGATGCATGGACGAGTTGTGTTCΆTGTATG GGGCGATTTCTACTTTCAGCCCAGTTTGGTGTTGTTGGGAΆTΆTTGTTTGTTG

AAAAGAGATTGGACATTATTTATCAGAGCAAAAGATATTGACCTTGATACTGG TAGAATCAATGTTGATTTAGATTTGTTACAACAAGAAATAGCTGAAGAAAAAG CTCAATTAGCTGAAAAACCATTCTATATTAGAATTTATAGATTTTGGTGCTAA

GAP1-4; ATGAGTAGGAAGTCTTCTATTGATATGCCTAAAGAGGCATCTAGCCCCGAGTG 186

AACQ01000199; CTACACAACATCGACATCCAGTAATGAAATAAGTGAAAAACCAGGCATGTGGC

46432706 GAAACTTCAAAGΆTTCATTCAAACCTCCTGTGCCCATCGATGATATTGAGAAT

GGATCGATATCTTCAACTCAATTAΆAAGGTGGACAGAATGTTCCATTACAACA

AAGTTTGAAAAAAAGACAACTACAGATGATTGCATTAGGTGGATGTGTGGGAT

CAGGGTTATTAGTGGCGTCCGGAGCTGCTTTGCGTAACGGTCCAGCAAGTTTG

TTAATTGCTTGGTTCATCGTTTCTACATTTTTGTATTGTACGATGCAATGTTT

AGCCGAATTATCGAGTACTTTCCCTGTGTCGGGATCCTTTGCAGTCTATTCTA

TAΆAGTTTATTGATCCAAGTTGGGGTACTGCCATGGGTTATAATTATGCATTA

TTTTGGGTTGTTGTCATGCCATTGGAGTTGGTTGCAAGTTCAATGACTATAAA

GTTCTGGCCATCAAATATAAATACATCTGTTTGGGTGGCAGTCTTCTATGTTT

TGATTATTGGTACAAATTTGTTTGGAGGAACAΆGAGCTTTTGGTGAGACAGAG

TTTGTTGCATCTGTTATAAAGTTGTTAGGAΆTTGTTGGTTTCAACATTTTGGC

AATTGTTTTGATTTGTGGTGGTGGTGACCAAGGCTATATTGGAGGTAAAAACT

GGCATCCTCCATTCΆCCACTGGTGTCAAAGGTGTGATATCCGTTTTATTGACA

GCAACGTATTCTTTAGCTGGTACAGAGTTGGTGGGGTTGACATCTGCTGAAGC

CGCTGGTGATGCTCGAAAAGTTTTACCAAAGGCAATCAAACAAGTATTGTGGA

GAATTTTGATTTTTTACTTGTTGACTTTGACATTAGTTGGGTTTTTAGTTCCG

GCCTCAGACCCACAATTAATTGGTGGTGGTAGCGGGGCATCTGCTTCTCCATT

TGTTATTGCAATTAGAGAAGGTGGAATCAAAGGGTTGCCTTCTGTATTTAATG

TTGTCGTCTTGGTAGCTTTATTGGCTATTGCTAACTCTGCGGTTTACGGATTT

TCAAGAACCATTTTGGCTTTGGCTGAACAAGGTGTTGCCCCTAGTATATTTAA

ATACGTTGACAGACAGGGAAGACCACTTGCTGGTATAGCCACTTCTGCCATTG

TTGGGTTGTTGTCTTTTGTTTCTGCCTCCAAACAGCAΆGAACAAGTTTTCGAC

TGGTTAGTCGCTTTGTCTGGTTTGTCTACCTTCTTCACCTGGGGAAGTATTAA

TGCTGCACATATTAGATTCAGAATTGCAATGAAAGTTCAAGGAAGATCATTAG

ATGAATTGCCATACAAGGCAAACACAGGTGTATTGGGAGCTTACTACGGTTTA

ATCATGAACGTTGCTGTATTGGCATTACAATTTTGGCTCGCAGTGTGGCCAAT

TGGAGGTAAACCAGATGCCACATACTTTTTTAAACAATATTTGGCTGCTGTCT

TGGTGCTTGCCGTTTACGTAΆTTCACAAAGTTGCTACCAGAAACTGGAAATTT

ATGGTCGATTACAAGGATATGGATCTTGACTCCGGAAGAAGTGATATAGATAT

TGATATACTTAAACAAGAGCTCGAΆGAAGAAAGAGAΆGCTTATAAGAGACAGC

CATGGTATTACAAGTTTTATCAATTCTGGTGTTAA

GAT2; ATGTCCAGTTCATCATCTTTATCTTCATCTACTACTACTACTGCAACAACAAC 187

AACQ01000243; CAGTGCACGTATTCGTTTACCATCAATAAGTGAATTGACTTCACGATCAACCA

46431962 TTAGTGGAGGTAGTAATAATGGTAATGGTTCTGCTTTGAAATCACAGATATCG

CCAAGATTGTCTGATACATCAAGΆATATTACCAAGTATACTTAAGΆATACTAG

TGGATCATCTACACCTACTTCTTCATCTACACCCTTTAAATGTCCACCAATAA

AGTCTACCATTGGCGGTACTTTATCAAGTGGAAACACTCAΆTCAAATTATGTT

TTGGGTAATACTAAAATAAATAATTTACCAAGACTTTCTTCACCTACATTGCC

CGCCAAAGTGCAACCTCAACAACAACCACATTTACCTCCTGCATCGTCACTTA

GCCCAGTGACAAGAGTAATCAATACCCCACCACAACAACCACAATCAGTTTCT

GCTTCTΆCATCACCAAATACCCAΆTACCAATACTATCAATACCAACAACAATC

TTCACCAATTCAACAGCAACAACAACAACAACAAGCCACCCCAGCTGCAACAC

CAACTGTCATGCAAATGGCACAAAATCAACCATCACACCCTGCCCCATTACAA

TACGCCACTCAACAGTACTATCCACAACCAGTATACTATCAAAGCCCAGCTGG

TGTGCCACCTCCACCACCATCTGTAACACATCAAGGTCATATAATAGCAGTGC

ATCAACATCCAGGCCATTTACCACAAGTTGGCGTTAATGGTATGCCACCTAAT

GTGGGTTACACTATAGTGCAGCCGGAAATCGTCAACAAATCAACTAACAGATG

TCACAGGTGTGGTACTACAGAGACACCTGAATGGAGAAGAGGTCCAAAGGGTG

TGAGAACATTGTGTAATGCATGTGGGTTATTCCACGCTAAATTGGTAAAGAGA

AAΆGGGGCAGCATTGGCAGCAGAAGAGGTATTGAATAATAAAGTGΆCAAAAGG

GAAGAACGGTCGAAGAATAAGTATGAAGAAACATCTTTTGAATGAGAGTTTAA

TTGATAGCTAΆAΆCAGTAGCATTAGTTTTTGCTATTGCACTGGGTATGTCATT

AGGAAAAGAAGGACCTTATGTTCATTTGGCAACTTG_TGTCGGGAATATAACTT

CGAGATTTTTCCCCTTTATTTATGAAAATGATTTTTTTGAAAAACΆGATTTTA

TCTGCTAGTGCATCTGCCGGGGTAGCTTTGGCATTTGGATCTCCCTTGGGTGG

GGTTTTATTTATTCTTGAAGAAATTAATAATTACCTACCATCTAATCAATTGT

TCCΆAATTTTCTTTTGTGCAATAATTTCAACATTGTTCTTAAAATTCTTGAAC

CCTTΆTGGAΆCTGGGAAAACAGTATTTTTTGAATTGGAATATTTTTCAGATTG

GAGTCCTATGGAATTGATTTTTTTCGTTGTTATTGGAATCATGGGTGGAGTCT

TTGGTGCCAGTTTTATCAΆGTTTTCTCAATGGTGGGCCAAAAAATTTAGATCA

AATAAACACATCAAAACCCATCCTATTTTTGΆAGTTTTCCTTGTTGCAGCAGT

AACTGGTATAATTTCATTTTGGAACCCTTATACGAAGCΆAGCCTCGGCAGAAT

TGGTATTAGACTTAGCAACACCATGTAGTGGAGGAGAATTAGATCGGTCATTG

TGTCCACAGACAGAAAAACΆATTGTTAΆACGAGTTGGCGTCACTTTTATTTGC

ATTTGTTGTTAAAGTATTTTTAACATTTATAACATTTGGGTTGAAATTACCTT

GTGGGATTTATGTTCCTTCAATGGTTTGTGGAGCATTATTTGGTAGAATTTTT

GCATTGTTTATTAGATGGTTAGAGTTTTTATCCAGGAAATCATCGTCATCGTC

CTCCGCTTTCTCCACACTTTCACTTCCAGCCCCACCATTGGAATTTGGCCTTT

TATGTTCATCTGCAGGTCCTCATTGTGTTGATATGGGCATTTATGCTATGATT

TCTGCAGGTGCGTTTATGGCAGGTGTTACCAGAATGAATATAACATTGGTAAC

AATTTTGTTTGAΆTTAACTTCATCTTATACTTATGTTTTACCAATTTCAATAG

CTATAGCTGTGGCAAATTGGTCAGGTGGATTATTGGAGAAAAACTCACTTTAT

GAATCATTATTAATTAGTAΆTGATTATCCATTTATGGCACCAGAAACTGAACC

CATAGATCCΆTATGTATCAGCTGGTGATATAATTAATCAAGATTCTGTTCCCA

CAACACGGATTTCACGACATATACCTCCAGATAGACAATTATATATTGATGTT

AGTGΆTTCCGGTTATGTTCCTGTTTCTACATTAGAGTCTAAACTTCΆAATGTT

GGCΆGATAGATGTTTΆCTTGATGGATGTATTGCCTTGATCAAΆAATCAATTAT

GTGTTGGATTACTTTTCTTTCTGGAATTGGAAATATGTCTAGATCAAATTAGA

GCATTTACATTGAAΆCACGΆTGTGΆAAGAAGΆACTTTATTGTAACTTGTTTGA

TGATGATGATGGTGATGGCGGTGGTGTAGATAATAAAAGTCTTTCTAΆΆTCCC

GTGCTATGCΆTAΆTGACAAAGTGGTTAAAAATATTTTGAATCAAΆGTTTAGAT

TΆTTTCAATTATGGGGCAATTAATGAΆGATGAATATTTAGΆAATGAAATCTTC

CATTGΆTGTGTTAACAAATTTAΆCAAATTTTGTTGATCGTGTACCAATGTTTA

TCAATTATGATACCGAATTATGTTTTGCTCATTTGATTTTCGATAGAATCGGG

AATAGAGTGATTGTTTTGATCAΆAGATGGCAAATATTATGGTGTCTTACATAA

AAAΆGTACTTATTGΆCTACCTTAGΆAGAACTGAATAA

GITl-3; ATGGCTTCTAGAGATTTACCTCATTCACTCAATGATCTTGCCTTTGGATGGGC 190

AACQ01000081; TAAΆCACCTTAAAGAAGAAATCATTATTAΆTAAAAATTCCCAΆCAATTAGTCG

46437325 ATGAAGATTTCCAACCTGATGAAGATGTCACTAAAGAAACCAΆAGTCAAATTA

AATAATTTATGGCCGGCATTTGCCTCCGGAGCTGGGTTATTTGCCGATGGGTA

TGTCAATAATTCTATTGGTATTGTTATGGCATGTTTAAAAATTCTTTATGGTG

ATGAATTCACAAAATCAAATGCCATTAGTAATATTGGATCAATTGGATTTGTT

GGTACTGTTGTTGGACAATTGAGTTTTGGATATATTTCTGATCGAGTAGCTAG

AAAAGGTGGGATGATGACAGCTAATATCATGTTGATTGCTTTCACTTTATTAT

GTGCTGTGGGATCTTGGGGTACTACTATTCAAGGATTTTTTGCATGTCTTACT

GTTTGGAGATTTTGTTTAGGTGTGGCTΆTTGGGGCCGAGTATCCAACGTCTTC

TGTCATTGCCTCGGAATTTGCTAATCAATTGCCTGCTGGTAAAAGAAATAGAT

ATTTCΆTTTGGTTCACAGGGTTTΆTGATTGATTTTGGATTTGTTGTTTCTGCG

TTTGTCCCATTTGTGTTATTGTGGATTTTCACTGAAΆAACATTTAAGAGCATT

ATGGAGAGTTTCGATTGGATTAGGTGCCATTCTTCCAACTGCCTTGTTTTTTA

TTAGATTGAAAATGAΆAGATTCAACTTCATTTGAAAAATTΆCATATGAAAAAT

GTCAGΆTACAGAGATTATCCATGGTGGTTAATTGTTAAATTTTΆTTGGTTTAG

ATTΆACTATTGTGTCTATGATTTGGTTCATTTATAΆCTTTTCAGTTTATTCAT

TTGGTACATTTAATGCCΆTTATTTTGGGCCAAATTATCCCTGATGCTCCATTA

TGGCAACAATGGGGATGGTCTGTTGTGTTCAΆCTTGTTCTATATTCCAGGTTC

TTTCCTTGGTGCCTTTTCTGCTGATTATCTCGGTCCAAGATTGACATTGGCCA

TTGGGGTTGGATTGCAAGGAATTATTGGGTTTATTATGTCAGCTTGTTTGAAC

TTTCGCTΆTTGCCATGTATACCCCATCTGGTTTCAΆGAATATTAGTTGGAAAA CATATATCATTTATGGTGTATTCTGTTTGGCCATGGGTACCCATGTCTACTTT GGATTCCCAGAAACCAAGGGTAAAAGATTGGAAGAAATTGGTCAAATGTGGGA AGAAAATGTTCCTGCTTGGAGATCAAGATCTTGGCAACCAACCATTCCTATTG CCTCCGATGCCGAATTGGCAΆGΆAAGATGGAAGTTGAACATCAAGAAGATAAA TTGATGAATGATGATTCTAACTCAGAATCAAAAGAAAACCAAGTCTAA orf6.3044; ATGTCGTCCAAGATCGAAAGAATCTTTTCTGGACCTGCTTTAAAAATCAATAC 193

Y16834; TTATTTGGACAAGCTTCCAAAAATTTACAATGTTTTCTTCATCGCTAGTATAT

3336838 CCACCATTGCTGGTATGATGTTTGGTTTTGATATTTCTTCAATGTCTGCCTTT

ATTGGTGCTGAACATTATATGAGGTATTTCAATTCCCCAGGΆTCGGΆTATCCA

AGGGTTCATTACTTCATCCATGGCTTTGGGTTCTTTCTTTGGTTCTATTGCCT

CCTCATTTGTTTCTGAACCCTTTGGTAGAAGATTATCATTATTGACTTGTGCT

TTCTTCTGGATGGTCGGTGCTGCTATTCAATCATCAGTTCAAAATCGTGCTCA

ATTGΆTTATTGGTAGAATCATTTCTGGTATTGGTGTTGGTTTCGGTTCTGCTG

TTGCTCCAGTTTATGGTGCTGAATTGGCTCCAAGAAAAATTAGAGGTCTTATC

GGTGGTATGTTCCAATTCTTTGTCACCTTGGGTATCATGATCATGTTTTACTT

ATCCTTCGGATTGGGCCACATTAATGGTGTTGCTTCATTCAGAATTGCTTGGG

GACTTCAAATTGTCCCTGGTCTTTGTTTGTTCTTGGGTTGTTTCTTTATTCCA

GAATCTCCTCGTTGGTTGGCTAAACAAGGTCAATGGGAAGCTGCTGAAGAAAT

TGTTGCCAAGATCCAAGCTCATGGTGATCGTGAAAATCCTGATGTTTTGATTG

AAATTTCTGAAATCAAAGATCAATTATTATTGGAGGAGTCCAGTAAACAAΆTT

GGATATGCTACTTTATTCACCAAAAAATΆCATTCAAAGAACCTTCACTGCTAT

TTTCGCTCAAATTTGGCAACAATTGACTGGTATGAACGTTATGATGTACTATA

TCGTTTATATTTTCCAAATGGCTGGTTATTCTGGTAACAGTAACTTGGTTGCT

TCATCCATTCAATATGTTATCAACACTTGTGTCΆCCGTGCCTGCATTATATTT

TATTGATAAAGTAGGTAGAAGACCATTATTGATTGGTGGTGCCACTATGATGA

TGGCTTTCCAATTCGGTCTTGCTGGTATTTTGGGTCAATACTCΆATTCCTTGG

CCAGATΆGTGGTAACGACTCAGTCAACATTAGAATTCCAGAAGACAATAAGTC

TGCCTCCAAAGGTGCCATTGCTTGTTGCTACTTGTTCGTTGCTTCCTTTGCCT

TTACTTGGGGGGTCGGTATTTGGGTCTACTGTGCTGAAATATGGGGTGATAAC

AGAGTTGCTCAACGTGGTAATGCCATCTCCACTTCTGCCAATTGGATTTTGAA

TTTCGCTATTGCCATGTATACCCCAACTGGTTTCAAGAATATTAGCTGGAAAA

CATATATCATTTATGGTGTCTTCTGTTTCGCTATGGCTACCCATGTCTACTTT

GGATTCCCAGAAACCAAGGGTAAAAGATTGGAAGAAATTGGTCAAATGTGGGA

AGAACGTGTTCCTGCTTGGAGATCAΆGATCTTGGCAACCAACCGTTCCTATTG

CTTCCGATGCCGAATTGGCAAGAAAGATGGAAGTTGAACACGAAGAAGATAAA

TTGATGAATGAAGACTCTAΆCTCCGAATCCAGAGAAAΆTCAAGCCTAA orfβ.4884; ATGATTACTATCAAGAACCATGTGATGATTACCCACAACAACAACAACAACAA 194 AACQO1000139; GAGCCTTGTGATTACCCACAACAACAACAGCAGGAAGAACCTTGTGATTACCC 46434401 ACAACAACAACCACAAGAGCCATGTGACTATCCACAACAGCCACAAGAACCTT GTGACTACCCACAACAACCACAAGAACCTTGTGACTACCCACAACAACCACAA GAACCTTGCGACAATCCACCTCAACCTGATGTTCCTTGTGACAATCCTCCTCA ACCTGΆTGTTCCTTGTGACAATCCTCCTCAACCTGATATTCCTTGTGACAATC CTCCTCAACCTGATATTCCTTGTGΆCAATCCTCCTCAACCTGΆTCAGCCTGAT GACAATCCTCCTATTCCAAACATTCCAACCGΆTTGGATTCCAAATATTCCAAC TGATTGGATCCCAGATATTCCAGAAAAGCCAACAACTCCAGCTACTΆCTCCAA ACATTCCTGCTACAACTACTACTTCTGAATCATCATCTTCTTCTTCTTCTTCA TCΆTCATCTACTACTCCAΆAAACTTCTGCTTCAACTACACCTGAATCTTCTGT TCCAGCTACCACTCCAAACACTTCTGTTCCAACAACTTCTTCAGAATCAACTA CTCCAGCTACTAGCCCAGAAAGTTCTGTTCCAGTTACTTCTGGATCATCTATT

TTAG

HWPl; ΆTGAGΆTTATCAACTGCTCAACTTATTGCTATCGCTTATTACATGTTATCAAT 195 AFO01978; TGGGGCCACTGTCCCACAGGTAGACGGTCAAGGTGAAACAGAGGAAGCTCTTA 2275335 TTCAAAAGAGATCTTATGATTACTATCAAGAACCATGTGATGATTACCCACAA CΆACAΆCAACAACAAGAGCCTTGTGATTACCCACAACAACAACAGCAGGAAGA ACCTTGTGATTACCCACAACAACAACCACAAGAGCCATGTGACTATCCACAAC AGCCACAAGAACCTTGTGACTACCCACAΆCAACCΆCAAGAACCTTGTGACTAC

CCACAACAACCACAAGAACCTTGCGACAATCCΆCCTCAACCTGATGTTCCTTG

TGACAATCCTCCTCΆACCTGATGTTCCTTGTGACAATCCTCCTCAACCTGATA

TTCCTTGTGACAATCCTCCTCAACCTGATATTCCTTGTGACAATCCTCCTCAA

CCTGATCAGCCTGATGACAATCCTCCTATTCCAAACATTCCAACCGATTGGAT

TCCAAATATTCCAACTGATTGGATCCCAGATATCCCAGAAAAGCCAACAACTC

CAGCTACTACTCCAAACATTCCTGCTACAΆCTACTACTTCTGAΆTCATCATCT

TCTTCTTCTTCTTCATCATCATCTACTACTCCAAAAACTTCTGCTTCAACTAC

ACCTGΆATCTTCTGTTCCAGCTACCACTCCAAACACTTCTGTTCCAACAACTT

CTTCAGAATCAACTACTCCAGCTACTAGCCCAGAΆAGTTCTGTTCCAGTTACT

TCTGGATCATCTATTTTAGCTACCACTTCAGAATCATCATCTGCTCCAGCTAC

TACTCCAAATACATCTGTTCCAΆCCACTACTACTGAAGCCAAATCATCAAGTA

CTCCATTAACTACTACTACTGAΆCATGATACAACTGTTGTCACTGTTACTTCA

TGTTCTAACAGTGTTTGTACCGAAAGTGAΆGTTACTACTGGTGTTATTGTCAT

CACATCTAAAGATACTATTTACACCACTTACTGTCCATTGACTGAAACTACTC

CAGTTTCTACTGCTCCAGCCACTGAAACACCAACTGGTACAGTATCCACTTCT

ACTGAACAATCAACTACTGTTATTACTGTTACTTCΆTGTTCTGAAAGCTCTTG

TACCGΆATCTGAAGTTACTACTGGTGTTGTTGTTGTTACTTCTGAGGAAACTG

TCTACACTACATTCTGTCCATTGACTGΆAAACACTCCAGGTACTGATTCAACT

CCAGAΆGCTTCCATTCCACCTATGGAAACAATTCCTGCTGGTTCAGAACCATC

CATGCCTGCCGGTGAAACCTCTCCAGCTGTTCCAAAATCAGATGTTCCAGCTA

CTGAATCAGCTCCAGTTCCTGAAATGACTCCAGCTGGTTCACAACCATCTATT

CCTGCCGGTGAAACCTCTCCAGCTGTTCCAAAATCAGATGTTTCAGCTACTGA

ATCTGCTCCTGCTCCTGAAATGACTCCAGCTGGTACTGAAACTAAACCAGCTG

CTCCAAAATCATCAGCTCCTGCCACTGAACCTTCCCCAGTTGCTCCAGGTACT

GAATCTGCACCAGCTGGTCCAGGTGCTTCTTCTTCTCCAAAATCTTCTGTTTT

GGCTAGTGAAACCTCACCAATTGCTCCAGGTGCTGAAACTGCTCCAGCTGGCT

CAAGTGGTGCTATTACTATTCCGGAATCTAGTGCTGTCGTCTCTACGACTGAA

GGTGCTATTCCAACTACATTAGAATCAGTTCCACTCATGCAACCATCTGCCAA

TTACTCAAGTGTCGCTCCTATTTCTACATTTGAAGGTGCTGGTAACAΆCATGA

GATTGACTTTCGGTGCTGCTATTATTGGTATTGCTGCATTCTTGATCTAA

IPTl; ATGATAACAACAACATCTATATCGTCGGTGATATTGACGATCCTCAAACCCCT 196

AACQOIOOOOOI; TGTATTTATATATCAATTCATTTATCGAGTTTATTGGTCAGGATTAAATCAAC

46445439 GTAATATATTACAATTGATTCTAAATTTTTGTATTAATTTCAGTCCAGTTTTC ATTTGGTTATTAATATTTAAAΆATGCTGGATTGATCCCTCATGAAATACGTCC TΆΆAATTCATGTCAAATTAGCΆTATCΆTTTGGΆTCAATACATTTTTGAAACTA TAATTGGTGGCATAGTTAATATTTTGGGATTAGCATCTCTGGGTTGGTTATTA TATCGTTTTGTTTATCAACTGAΆATCGAGTAATAΆCAATAGCAACAGAAACAA CCATCACCAAAGTCAAATTTCTGGTGAGTACCCTCCTAGCAATGCCAATGACA TTTATTCATTGTACAAGATACCACAAAATTATGAΆTTGGATATCGACAΆCGAT AGTAGTAGTAGTAATAGCAGCAATAATAGTGATATTGAATTAGAATCATTTCC TAAAGAATTGTTGAAACCTTCTTATAΆTCAATTACCACCAATAAATTTCCAAG ACAATGACGATCAAATACAAGACTCACAACTAGATAACAATAGGGTCCATGAT GGCAΆTTCAGAGAATACTCGATTTGCGCCAATGGTATTTATCCCACAATTATC TCTGGTTCAAGTTGGTCAAATGGCACAΆTCAATCAATAATAAΆATTCTTAATC ATATCCATCCAAAAAATTCAAATTCTGGGTTCAATGATAATTATTCCCCCATC ATTCATGGGATTTTTGTCCATCATTATTATTAG

SKNl; ATGACTCGAGGTAAGTATAACCAGAATACAAATCGGTCAAGTTCAAATTATAT 197

AACQ01000066; TCAACACAGTCCAACATCAGCAGGGTACGATAGATATCCGCTTAAAACTCAΆT

4S438258 CCΆGTATTGGTGGATCAATGCTGAGAΆTTGGTTTATCATCATCATCGCCATCΆ CAACAACAACAACAACACATGTATGATAACAATTCATCTAATCGATCTCTGTA TTCACCTGATTCCGCCACTGATTTAATGGTTTATGAAAATGGAGAATTTAGTC CATTTGGAGGATATCCAGCAAGTTTATTCCCCTTAAGTATTGATGAAAAAGAA CCCGATGATTATTTACATAATCCTGATCCTGTTCAAGATGCCGAATATGATAΆ AΆATCGGTTTTTATATGACTTAAAAACCATGGATAAGAAATCTATGAATGGAT TAATTGCATTTATTGTAΆTGTTTTTAΆTTGCTΆTTGCTATATTTATAATTTTA

CATCATACCTGGGGCATTTATTGATACGATGAATTCTTTCCGTACAACGTCAG

CAGCATATTCAATTTTTTTTGTTCAAATCGCATCACATTGGTGTGGCAAATGG

CTAGCTAGAATTCTTCCTAAAAAGCAAGTTGGTTTTGGAAGATTGTCGTTCAA

TTTAAACCCGGGGCCCTGGTCTATCAAGGAAACGGCTTTGATTACAATCACCG

CAAATAGTGGTGCAACGGGGAGCATGGGTACCAATCCTTTGGCGTTGGCAGAA

CTTTTCTATGGTGAΆΆCTGTCAACCCTGCTGTTGCCATTTTCTTCATGTGGAT

GATTGTGTTTATTGGTTACTCATTTGCTGGTATTGCCΆGAAATTTCTTATTGT

ATGACCCTCAATTCACATGGCCACAAGCTTTGATGCAAACAΆCΆTTATTTCAA

ACCCAAAGTAAAAGTGACAAAGATGCCAAGCAAGCATCAAAGCAAATGAAAGT

GTTTTTCTTTGTCTTGATTGGTTTATGTATATGGCAGTTTTTCCCGGAATATA

TATTCCCCATGACTTCTTCGTTGGCTTTTCTTTGTTGGGTTGCGCCAGAAAAC

TATACAGCCAATTTCATTGGATCTGGTCTTGGTGGAATGGGGTTTCTTAATCT

TTCCCTTGATTGGTCAAATATCACCTCGAGTATTATGTTGTATCCGTACTGGG

TGCAAGTAGTACAATTCGCTGCGTTTGTTCTTGGGGCATGGATATTGATCCCA

GCTGCCAAATGGGGGGATCTTTCAAGTTATCCTTACGGGTTAATGTCAAACAG

TTTGTTTTTAGGTAACGGTACCAAGTACCCAACTACCGAGTTGCTCACGCCAA

ATTTAAGATTGΆACGAAACCCGATACGAAGAACTTGGGCCAGTGCATCTTGGT

GCCCAACGTGCTTGGAATATGTTTTTCGATTATGCTGCCTATGTTAGTGGATT

CATGTGGGTTGTTGCTTTTGGTTATAAAAGCTTGTCAGGGTCGCTCAAAAGAT

TGGTGAAGTCAΆGAAΆACAAAAGGGGTCCATAAΆTTTGCAATACACTGATAGG

TTGAATAAACTTCAAGCAGCCTATGAAGAAGTTCCATTGTATTGGTACGCTAT

TCTTTTCTTATGTGCATTTGTCACTCTTTTAGTGATATTTGCAΆCGΆACTCGT

TATTCATGCCGTGGTGGTGTCTTCTTGTTGGAGTTGCCTTTGGTGCTGTGATT

GTTACTCCTTTAGTTTGGTTGTATGCTCTATCCAΆCTTCCAGTTGCCCATTGG

TACCTTCAATGAATTATTATATGGTTATATGATTCAGAACAAAACGTCAAGAC

ATCCAGCTGGAGCTΆTGGTGTATGGTGCAGTTGGTGGGGATTTGTTTTACAGΆ

GCCCAGTATATTCTTAATGATCAAAAGATTGCCCATTACATGCACATTTCTCA

AAGAGCAGTATTTTTCTCGCAGATATTTGGAGAATTAATTGGTGTACCCATCA

ACTATGCCGCCTTAAGGTGGGTGATCCTGTCCAAAAGAGATTTCTTGGATGGC

ACAAAAGTCGACAAGCTTCACCAATGGACTGGCCAGACCATTGTCAGTTACAA

CACTAATGCTGTGCAGTATGTGATTTTGGGACCAGATAGATTATTCAAAAACT

ATCCAGTATTGCCATATGGATTCTTGCTTGGTGCTGGTGCTCCACTAGTATTA

TATCTTCTTCACCGATTGTTTCCCAAATCGAAATTGAAGTTCCATTTGTGGAΆ

CACCACTGTATTCTTTTCTACTATGAGTACCTTCTATGGTAACCTTTCAACGG

GΆTATTTTTCCAGATTCATTGGAGGGACCATAACAATGTTTTGGGCATTCAGA

TACAAGCACAGTTTATGGAAAAAGTATAATTATTTGTTGGCAGCTGCTTTGGA

CACTGGCCTTAATTTGAGTΆTCTTACTTATTTTCTTGTTCTTCTCGGCTGGTA

AAΆCAGTCAATTTCCCCGAATGGTGGGGCAACAATGGCAAGAGTGTGGAGAGA

TGTTTTGCCATGAGTTGA orf6.2773; ATGCCCAACACACCTTTACTTCTGATCAGATCTCCTAGATTTGACAGACTCTC 200

AACQ01000139; CCCTAGAATCACAACAACAACAGCCACAACAACTGATCCCAATGGTATTGTTG

46434401 ATATTATCAACCAACAGGAAATACAΆAATTATAAΆCTTGGTATAΆTTCTTCTT GTGATTGCATTGGCTACTTGGATTATTGGATTAGAATTGGTCAΆTGCGGTATT AAAAGGAGATGATTATGAAAAACCTTGGTTATTTGCAGTGATCACTGGTTCAT GTTTCTCAATAAATTTATTΆCCGGATATAATTCTACTTAAACΆCTGGGAAGTT TTCGGTCAAACTCAAATTGAAGAAGACTTACCATTACTTCAΆΆCGAAATCAAA AGAAAΆGAATGAAGATGTTTCAGAATTAACTCCCAΆGGAAGTGTTTATTTTGG CTTTTCAAATCGCAGTTATTTATTATTCATATAATGTCCTTGGGATGTCTGCG TTAAΆGTTCACATCAGCTCTGAATCAAΆCAGTCATGGGTTCAACAACATCΆAT GTTTACTTTGATTATAGGAGTAATACTCAAAACCGAAACTTTTACAATTAAAA AGGCACTΆTGTGTAATTGGTAGTTGTTTGGGTGTCTTTATGGTΆAGTTTTAGT AATACTTCAGCGGGGCAAGGCAAATTCCAACCGAAΆΆATCCCGTTCTTGGAAA TACATTGGCATTGGGTGCAGCATTAATGTATGGTTTTTATTTACTTΆTTATGA AATTTAAATGTGGTACTGGGGATAAΆACAΆCTAATGAΆAGAΆGACTTTTCGGA TACGTGGGATTAΆTAACTTTTGTAATTGGTGTGCCTGTGTTATACGTGGTTGA TTTATTAGAAATTGAAAAGTTTCAATTCCCTCCACCAAATAATACTATTTTAG

ATTTCTATTATACAATTTTTATCAACTTTACCAAATTGTTTAAATACTGTACC TCAAGAAGTTΆTTGAAGATAATAΆTAATAATAATAATAATAATAACAAAATGC ATGGΆATCACΆAATTATAATTTTCAAΆTCAAACAAAAAAGTAGTACCCCTTCT TCAΆGTTCATCAATTTCTGTGACGGTCTTAGΆTTCAGAAGΆTCATTTAATTGA TGATTCACAΆATGACTTATTTATATCGAΆTTAATAATGAATTATTAAATGATT ΆTAAATTATTATTTTTCCATTATCCATTΆCCTCAATTTCGTCCAΆAAGGGAΆA TTTAAAATTGTTGGATCATATAATGAAAAACATGAATTAGATCGTAAAACAAA ATTAAAΆTTTCATGATGATATAATAAGTTGTGGTTΆTAATGTCATATCTGTTG GTCATGAACATGAAAATGATGCTTGTTTATTΆTCATCGTCATCGTCATCGTCC AACTCCGATAAATCAATTTGGTTΆTGTTATAATΆGTATCACGGGTGATTCAGG TATAΆCTAAATTAGATAAACAATACGTTAGAAAATTACGATTATTTGAAATTG

ATTTTGAAAAAAATCGAATTTTAAGTTGGAAACGTAAAGAAATTGATAATCAA CCATTTGATTATCAACTGATATATGAAAAACCTCAAAAAAAGGAAAAAGAAAA GTAA orf6.3214; ATGGATCAAACATATTTGGACCAΆCAACΆATTGGATGCΆAATGTGAATCACCA 203

AACQ01000055; ACAATTATCCCAAGATACTAATCTGATTCCACAACAACAATTGCAACAGCAAC

46439033 AACAGCCGTTGCAACAATTACAGCAGTACCAACAACAACCACTAAGCAATGCA

AACTTTTCTGGTGACAACAGATTTCAGCAATATCAACCACGAGTAACTCCTTC

GGTTTCTTCTTCCCAACAATCAATACATACTACCACCGGATATGTAACAATGC

ATAGTGGTAATTACACCCCTAATCAACAATATGGTGTGCCAAATCAATACACT

GTACTCCAACAACAACCACCACGACAACAATCATATGAAGAGAATATTAATCC

TCTCAGTTATAATAGTAATGATAGAACATTGAGTGCCCCTATCCCACCATTAC

ATATTCAACATCAATTGGCTTCCAAACAAAATCAGGACCAAAACCAATCACAA

AACCGTTACGAGCAATCTTCAATGACAAGCATACΆTACAΆATGACAACAGCTC

ATCAGTTAACAΆTTCTCCAAACACGATGATGATCAAGCAΆGAGCATTCCACTT

TTCAACCACΆACATAGTAΆTGAAGGTAGTAGTGCATATCATCCAGTTGATCAA

CAAΆΆTCATCAΆCAGCAACAACAGCCTCAGCAACAGCAACAGCCTCAGCAACA

GCAACAGCCTCAGCAACAGCAACAGCCTCAGCAACCAATGACTAGATCCATTT

GTACCAGGTGTAAAAAAGGATTTGACCAACCAATAATTTATCCAAAATCAAGC

AΆTTCTACCAATGGTAACΆACAGCAATGGACAAAATTCGTCATCAATACCTCC

GCCTGAGCCAAGAACTTTCAAACTATGTGATCATTGTCGTAAATTACAACGTC

AACGGTCGAGAAGATGGCAGAAAAAAACTAAGGATAGAGAAGGAGTATGTCGC

AGATGTGGGTCAGAΆΆTACCATTGGCAGAAAGAAGATTTGTTTTGTGTCCTAG

TTGTCGGGAAAATTTACGTTTGCGAAAAGCTAGTCGGGCAGCCCAAGGGAGAT

GTGTTCATTGTTCGGGGCCΆTTGGATGCATCTΆTTTTATCCAAAGAAAACGAA

GGTAACAATAATGGTGATGAGCAGAATAATAΆGTCAAACGAAGATCAAAATAA

CGAGCTGAGAAGAGGAAGCCAAGAAGAAAAGCCTGCACGAGGTGCCAGTCACA

AAGTTTGTCAAAGATGTCGAGAAAATGATAAAATCCGAAGAGCAAATTTGGAA

AAAATGGGTAACTGTAATCGATGTGCTAAGGCATTAGATCCCAATGAATATGG

TAGAAATAAAGTTTGTTTTAATTGTCGAACTAAAAAGAAAAGATCACCTCCTG

AAAATGTCACAAATACTGATGAAGTGAGAACTTCGCCAATTCAAAACCAATAT

GGAATGAΆCΆTGTCGCATCAATACATTCAACCΆCCTCCACCGCCTCCACCACC

TTTAATGACAGGTCATCACCAGTTTCAACCTCAACCACATATGATGGGTCATG

AACAAATGAATACGTTCACAACAATGTCΆAACTCTGGTGTAGCTGGTATTCAA

CAACCAAACAATGGTATGGTAGTAGGTGATCAACAGCAACAACAACAACAACA

TAATGGCTCAATGCAATTACAACCTACGTACTATCAATCATATGTCCAAATGC

CACCTCCACTACAΆCTTCAGCAΆCAACAGCAACAGCAGCAGCAGCATTATTCA

CTCGACGGAATTCCCCAGCAGCCACATTCTGCGCCTACAAGTTCATTTCCACC

TCCACCGCCTCCACCATTGCAGTTGAATCAGCATCAGGGGCTTCAACAATATA

GTCATGCTCAACAACAACAGCAGCAGCAGCACCAACAGCAACAACCATACCAC

CAAGAGTATCCAAACAATTAA orf 6 . 4504 ; ATGCATTTCATATTCTACTTGATTCTTTTAGTATCTGCTGCTGATTACGGTAA 204

AACQ01000129; CTTTGGTACATACCCAAAΆGTCCCTAAAACTGCTTCCATTAATGGGTTCGCAG

4S434795 ATCCAΆTCTACGATTTATTACCAGACTGTGCAΆAGGAATGTGTCAAATTCAGT ACAAGTAACACCCCTTGTCCATATTGGGATACAGGATGTTTCTGCGTGATGCC ACAATGGGCTGGTTTAGTTGGTCAATGTGTTGCTCAAAAGTGTAAGGGTGAAG ATGTTGCTAGTGCCAGATTCTTGGCTACTTCGTTGTGTTCAGTTGTTGGTGCT AΆTACTTGGATGATGCCTGCTTCTATTTCCTCGATGCTTTCCACTGCCGCTGG ΆGATGCTAAGGΆAGTTACTACAATTGAAGGGAΆAACTGCTAAATCATGGGTTA CTGCTCCAGGAAGTGCTGCTGGGΆGCGTTGTTTCCGAAACTGGTAGTGCAAGT GAAACCGGCAGTTCCGAATCGGCTCAATCAACAACTACAGGCTCGTCATCTAC AGGCTCATCATCCACAGACTCCTCCTCTTCTTCTTCCTCATCTCCTTCATCTT CTGCTAATTTTGCTGTTTTGCAGACAGGAGGAATCGGATCGGTAATTCTTGGA TTCATGATGTACCTTCTTGTATAA orfS.4507; ATGTTCTTACACCCAGCAACTTTTGCAGGCACACCCAACATCATTGCTGTAGA 205

AACQ01000129; GGGCAACACTGCTGTTCCGCCTGGAACATACAACCCAACATTCTCAATCGGCT

46434795 TAGCAAATCTAGAACAATATACGCCGGGACTGGTTTCTACTGTCATAACTTTT TCTTTTGGTAATTGTGCAGCATGGAACTTTTCGATATTTTGCATGGACAAGTC AATGGCAGCCTTCATTTCTTCTGAAATATCCATCAAATCAGCCGGGAACGGAG CTTGTAAAACAGGAGCATCAAGTTTTACACCATCAAACTTGGAAGTCAACTCA ATAAGTGCTTTGTCTCCATCAGACTTGACTTTTTCAATAATAGGAAGCACGAG TTTCATAATGTCTGCAGTCTTTTGTACAGGTCTTGTCATTGCACGCTCAACAG CAGCAGCATCGTCAΆCACTAACAATCTCTΆGCTTGTAA orf6 . 6077 ; ATGTCATTTTGGGACAACAACAAGGATTCATTCAAGTCAGCTGGTAAATCGAC 206

AACQ01000151; TTTCAAGGGTATTACTAGTGGTACCAAAGCTGTGGGACAGGCAGGTTACAGAA

46434012 CCTATAAAAAGAATGAAGCCAAAAGAAAGGGTGTTGAATATCATGACCCGATT

AAAAATGAATCGAAAAGCGGAGAGACAAATGTCCCTTATAACCCAAGTCCATT

GCCTTCAAAAGACAAATTGAGTTCATACCAACCTCCACCTAAAAGAAATGTGG

GCACTTTTGGTGTTCCCCAAAGGGGAGAAGCTTCTCACTATTCTGCTCCTGCG

CCTACTTCGGGTCAAAGTACATATCCTGCAAATCAACAACAATATCAACATCC

GAATGAAATTCAAACCAGCAGTGGCTATCAAGAACCACCTCCGGAGTATCTGG

TAGΆTTCTAATAGTGACΆTGCAGGGATTTTCTGCGGGAAGTGAGTATCAGAGA

ACAGCACATCCAGCTCCGGCCAGTACTACTTTTACACCAGCTAATCAAACTAG

TTTTATTGCACTGCCTCAGCCAACTTCAATAGCTACGGACAATGCAATTCAGA

ATATACAACAGCAGTATAATAGTGTGCTGAAΆCAGCCATCACCAGCACCAGGG

TTACCACCATTACAGCACCAACCAGGGAACTTGGTTAATCCACCATTGCCCCC

ACAAGTGCCCCAGAAAAGTAATGTTCCTCCATCACTTCCTTCAAGAACATCAG

TTGCCAGTGTAGCAAGCTCCACATCTCAGCAAAGTGTTGGGCAAGGGAGTTTT

GTGAATGCACAGGAACAACCCAAACCTAAGCCAGCTTTGCCCGACCCTGGATC

ATTTGCACCACCACCAAGAAGACGTGACCAACAACCAATTAAACCCAAAATTT

TAACCAATAACTCAACCATGGGAAATGAGAAAATGCTGAGTCCATTAGTGCAA

GGGCAGAGCTCAAGTCTGAΆTATTGGATTACATCCACTGAAGTCTATTAGCGA

AAGAGAACATCAATCAGATTACAGTGACGCTCTGCTGAAACCACCATCGTTAC

CAAGTAGAACGAGCTCTTCTCACTCCAACTTACCTTTGAAACAAAAGCCACCG

AAACCAAAGAAACTTCAAGGTGATTCATCAATTACGACTTCACACACACCAGG

CTATAACTCAAATTACACTCATAATGTTTTTTCAGCTCGAAGCGAAGAAGAAT

ATGCAACGCCTCCAAAACCACCACGTCCAGTTGAAGACGAGGAATATACAAAT

CCACCTAAACCACCCAGACCAGTAGAAGATGAAGAATACACGAATCCTCCTAA

ACCGCCTAGACCAGTTGAAGATGACGAGTACACAAATCCACCAAAACCTCCTC

GTCCAGAGACCCAAAATTCTTCTGTGGTGACACCAAGAGCTATACCTGATGCC

ACTGAGCTATCTAACAAAAAGCCTCCACCACCTAAACCTTTGAAAAAACCTTC

AACATTAGATGGATCAACAAGTTCCCCTCCTTTATATTCCGAGCTTGATAACC

TGTTTAGCAAACCGAAGCAAATAATCTCGGAATCTACAAACTCGCAAAGTGCA

GTCCTGAGTGAGTTGAACAGTATTTTTCAAAAAATGAATATTAATAAAACTGA

AAGTGAGGCACCTGCTAGTAGTCCTGAAGTTAAACCGAAGCCCAAACCGAAGC

CGGTACCAAAACCGAAACCCGAGATGATTACTAAGAAGCΆAGAACTGCCGGAA

ACCAGTATACGAATAGCAACGACAACTAAACCGCCACCACCCGTGCGTCGTCT

TTCCACACCCCATAAGTCACCTTCTCCACCACCAGTTCCTCCAGCGAGAAATT

ATAGCAGGGCTCCTGCTCCACCACCTCCAAAACAATCTGGCCCTCCAAATTTG

GATTTAGAATTATCGAGTGGTTGGTATGCCAAAACCAATGGACCATTGCAGTT

ΆCCCAAAGTATTTCATGGAATCAATCACAAGTTTTCGTACACGACATCATCAG

GCTCTTATGGGAAGGGTACCACAACTTTAACTGTGAGΆCTTAAAGACTTATCC

GTCACCACTGGTGTTGTTGTTGTTACATCTGAAGATACTGTTTACACTACATT CTGTCCATTAACTGAAACTACTCCAGCTACTGAATCAGCCCCAGAATCATCTG CACCAGCCACTGAATCAGTTCCAGCTACTGAAAGTGCTCCAGTTGCTCCAGAA TCATCTGCACCAGGTACTGAAACCGCACCAGCTACCGAATCAGCTCCTGCCAC TGAACCTTCCCCAGTTGCTCCAGGTACTGAATCTGCACCAGCTGGTCCAGGTG CTTCTTCTTCTCCΆΆΆATCTTCTGTTTTGGCTAGTGAAACCTCACCAATTGCT CCAGGTGCTGAAACTGCTCCAGCTGGCTCAAGTGGTGCTATTACTATTCCGGA ATCTAGTGCTGTCGTCTCTACGACTGAAGGTGCTATTCCAACTACATTAGAAT CAGTTCCACTCATGCAACCATCTGCCAATTACTCAΆGTGTCGCTCCTATTTCT ACATTTGAAGGTGCTGGTAACAACATGAGATTGACTTTCGGTGCTGCTATTAT TGGTATTGCTGCATTCTTGATCTAA

RBT5; ATGCTCGCCTTATCCTTATTGTCAATCGTTTCCATTGCTTCAGCTGCTGGTGT 220

AF254145; CACTGCTATCCCAGAAGGTGATAATCCATACACTΆTTTTCCCAAGTGTTGCTA

9963987 AAACCGCTTCCATCAACGGTTTCGCTGACAGAATCTACGACCAATTGCCAGAA TGTGCCAAAGAATGTGTTAAGCAAAGTACTAGTAGTACCCCATGTCCATACTG GGATACCGGTTGTTTGTGTGTTATGCCTCAATTTGCTGGTGCCGTTGGTAACT GTGTTGCTAAAAACTGTAAAGGAAAAGAAGTTGGTTCTGTTGAATCTTTGGCC ACTTCCATTTGTTCATCTGCTGGTGTTTGGGAACCATACTGGATGATCCCATC AAGTGTTTCTGACGCTTTGGCTAAGGCTGCTGATGCCGCTGCTGAAACCACTG CCGAATCCACCACTGCCGAATCTACTGCCGCTGAAACCACCAAGGCTGAAGAA ACTTCTGCTAAAGAΆACCACTGCTGCTGΆΆΆCTTCCAAGGCTGCTGAAAGTTC TGCACCAGCTGAAACTTCTAAAGCTGAAGAAACTTCAAAGGCTGCTGAAACCA CCAAAGCTGAAGAATCTTCTGTTGCTCAATCTTCTTCTTCTGCTGCAGACGTT GCTTCTGTTTCCGTTGAAGCTGCTAACGCCGGTAACΆTGCCΆGCTGTTGCTAT TGGTGGTGTCATTGCCGCTGTTGCTGCCTTATTCTAΆ

RFX1-2; ATGTCCAATAACCCACATAGAACACATAAACGACAGAAATCGTCAGTGCTGAA 221

AACQ01000006; CCCTGGATATTATTTCACACCTGAGACCΆΆGCTGGAGATACΆGCAΆCAACAAC

46444619 CACAACAGCAAGAAAGTCAACAΆCAACAACAACAGCAGCAGCAACAGCATTCC

CAAACACACAATATCTACGATAATGACAACTACATGAATTACAATTTTCCACC

CACTAGCAATAGΆCCTAGAGCTTCGACΆACAACAGGΆACAΆCATCTACCACAC

ATCCAGGAAGCGAATTΆTCTCATGAAAGCCATTCCGTGCATACTTCGCCTTTG

AAACGAACAGCATCATCAGAGCTAGATCAACCTATTCCAGCCATGGCACCATC

TTCTCCCCTAGTAAGCTCAGCCCCATATTATTACCAACAΆCCATCTCAACAGC

AAAACCTTTCGTATCATGATCACCACCACCAACAGCAACAGCAGCAATCTACT

CCTCΆΆGGTCAGCAATTATCTCAGCAGACΆCAΆCTGAΆCCTGCAGΆGCGGAGT

ACCGCCACCACTATACGGTACTΆGCTCAAGTATTCCTCCTGGATCAACAATGC

AACCCAGCACTTCGTTTGCATTTCACACTTCGCATTCAACATATAATCCTTCA

TTTGACTCCTCCAATTTATATAΆTCTGGCTTTCAGGTTGCCAGAATΆCCCGAC

TACTAGCTCCAGCTCATTATTGTCTACCACGGGTGGTAAACAGTTTCAACAAT

CTTCTGCATTATTACCATCTGGTACATTGCCTCCTTCGATTTTΆGGCΆCATCA

TCATCACTGCATGTTTCTGCTTTACGACAACATCAGAAAAACAACTTGTCCAT

TTCTTCCCATTTAACGTTATTTAGTCTAAGTGGGΆACAΆCTCTTCACAΆTTGC

AGTCGCAAGGATCTTCGTTTCAACAATCTGAAACTGGCGTGGATGATACCAAA

CGATCTTCAAΆAGAATCAACAACCATCTTCAATGATTTATTGTTTCATTTAAC

TTCTGTTGATGGTTCAAATATTAATACΆTTCTTGCTATCTATATTGAGGAAGA

TCAATTCGCCTTTCACTTTGGATGACTTTTACAATTTATTGTACAATGATAGA

CAACGTACATTGTTGGATAATTCGAATTATCAGAACCGCATTGACAAGACAAT

TGTTAGTCCAAGTGACACAGΆTATGACGGTTTCCATAATCAATCAATTGTTGA

ΆTTTTTTCAAΆACTCCTAGCATGTTGGTTGACTATTTCCCAAACATGGAAGAC

AAAGATAACAAATTGGCAAATATAAACTACCATGAATTACTTCGTACATTCCT

TGCTATCAAGATTTTGCATGACATTTTAATTCAATTGCCAATCAGTGAGGATG

ATGATCCTCAAAACTACΆCCATTCCTΆGATTATCAΆTCTATAAAACCTACTAT

ATCATCTGTCAGAAATTAATAGCAAGCTACCCAAGTGCATCCAATACCAGAAA

CGAACAACAAΆAGTTAATTCTTGGTCAATCAAAGCTTGGTAAΆTTGATCAAGC

TΆGTGTATCCCAATCTATTAATCAΆACGATTAGGTAGCAGAGGTGAATCAAAA

TACAACTΆTCTTGGTGTAΆTGTGGAATGCAΆATATTGTTCAΆGAGGAAATTAA

CTTTGAGTGTGAΆGCAAΆAAATTGCTATTGAAAATGAATTGTCΆAATTTTTAT

GAGGATTTATCTAAGAATGAATTGCATTTGAAAACTGCTGATGAAGCTGGCTC

TTCATCAATTAGTCAATCTCAACATCATCACAGTCATCACAATCATCATCACC

ACCACCACCATCATAATGACCATGGCCATCACAACAATACTCTTGGCAATAGG

TTGTCCAAGGCCAGTCAAGATTCAGCAGCΆACAGAAACGACTAATGCTAGCAC

AAATAGTCCAATTACACCAGCTAATGAGTCAAATAATGAAGATGGTGCTGTTT

TGACACGTCAGCAGTCAGCTTCCTCAATATGGTCTACTGATACCACTAATCGT

AGATCATCTTTGGCAATGAAGAGATACACCACCACCACATCAGAGATATCGAA

TTTCAATGCAACAGCCCAGAATCCAAATCGCCTGCCAGTACAAAGAGTTGGTA

TGGCAAGGGCTTTGGTTGGACACCAACGTCAGCAACAATTCCAATCAGAAAAA

TCCTCAATGTATAAAAATGGCAATCCGTCGTTGTATTCTCAAGCTTCAGCTGT

ACCΆCAATTGAAGAATCGTCCTTCATACGATCAAATGAAGAGTTTAAATAAAC

GCTCTTCACGTCAGTCTGTTATATCAAAGGATTCTAGCCACAATGATGATGAT

ATGATTTCGGTGTTGTCATTTGATACTATGAATTTGCCAATGCATGATGAATC

GGACTCCCAACGTTTCAACCAACAAATGGAGGATTTCAATGTTGATGATTATC

AGGATAAATATGATTTAACCTTAGAΆTTGCAAGGATCACCGTATTTGAAAGAA

GGGTTGTTGAAATTGAAAATTTTAAACAATGATTCAGTTGATGAAATAGATGG

CAACTCTAATCCCTCGGCATCATCTACACCAGCTAATCACGGCAAGTTCTTGT

CATTTTTCAGTAGACCAGCTAATTCCAGTTCTTCTACTTCTAACATGAACAAT

CACAAATTTΆCTGAAAATTTTGTGGTTATAAGTAAΆGGAGAATTGTCATTGTA

CTCATTTGATCCAAAAGTTATCAAAAAGTTCAAGAAGAGAAATGGCCACCAAC

AACAACAAACTGAACCCGATGACGATGACATTGTTGGCGATGGTAATTGGTTG

AAAAACGCTGCCAAGATTGGTACCTACAATTTATGCTCTACTTATGCTGATTT

AGAAAAGACAACTTCTCAAGGTAAAGTTTTATGGTCATTAACATTCCCCAAAA

CTTCGAAACGTCAACCCAAAAAATTTATATTTGAGGCTGGTACCAAAGAGGTT

GCTTTGGAGTTTATAAATACTTGTAΆCTTCTGGGCTGCCAAAATAΆCTGCTAT

TCCAACATTGGAAGAAAGTGTAAGCTCATTAGAATATGGATGGACCAATTTGG

ACTATATTATTGCTCATCGCGAGTCATTTAAAAAGTCCAGΆAACATAATGAAA

TΆTGAACCCGTCGTCAAGGGGGTATATTTGTCCAACTATATTGTTAATAGTGA

AGAAACCAATCATTTGGGTATGATGAGACAATTTGTTAAAACTTCAAACTATT

ΆTAACCAATTGAAGAAATTGTATAACGAATTCACTGAAATGAGGCAGAAGTTT

TTGATCAATTTACCTAAATGTCATTTCAATTGTTCAAATCATAGCAAAATCTT

GTCTAATTATGACACCAAGATCAATGACTATAATTTGGAAATGAAAAAATATA

AGAATTATTTGATTATTCTTGGGTTTGGGTTACAATTGAGATTTGATTTAGAA

GAGCAAGATAGACAACAACAATATGATACATCTTTAGAAAATGAAGATGTTGA

TGATGATGATGAΆGGTGAAGAAGATTATGAAACTATTGGTGAAACTTTAGCAA

CCACTGATAGAGCAAGCAGTGCTGGAGCTAAAAGTAATGATACATCTTACCAA

GATGΆTGAGTTGACGAAATTGGTTAAATTTGAGATCAAAAΆGTTATTTTTCAA

TATGAΆAGATATCTCAAAAGTGATTCCAΆCTTTCCGΆTCACTGΆAATCAATTA

AAAACTTGGCTGATTTGGCTCAAGATATTGACAACAAGTTGGTTAAATCACCA

AAGACATTTACTTTAGCAAATTATAATGATAATGAGΆGCCCAATCAACCAATT

ACTTGCTACCACTAACGCCAATCCTACCGTGAAATCCAGTTCAATGATAATGG

AACTGTCAATCGCTGAAGAACCAGAAGATGCTGAAGATAGTGAAACCACTAGA

AGAAGCAGTAAGGTTAΆTAACTCAAAAGATCATTCACCTGCTACAAGTATAAG

TAGTAGTATTAAAAAACCAAATTTAAAGATTGCTAATTCAGAAGTATCAGCAT

TGGTAATTTAA

YFR003C-2; ATGTCTCAACAAAGAGAAAACCAAAGAGGAATAGTTTCACAAACAACTACAAC 225

AACQ01000092; GACTGCCTCGCCTATTTTAAAGCTACGAGCTCAAGAAAGACAAGCTCGTGACG

46436607 TCTCTTGGGATGCAAACGTCGTTGATAATGAACATCTAAATAAGAAAAAGACA AAAΆTATGCTGTATATTTCATCCATCAGATCGGAACTGTGATGAAGAAGATAG TTCAAGTTCCAGTGACTCGTCTAGTGATTCTTCAGΆTAATGAAGΆGGATGATA AAAACACGAAGATAGCCCCGAAATCTAACAATAATAAAAAAAAGTCAAAACCT ΆΆTGCGTACGAAGTTCAGCCCCATTACAAAAACCAATCAAAGGTGCCCGGAAA

ATGA

YGRl61C; ATGGTTAATAATCTCACTTCTGGTATTGCAGCCACGTCGTTTAAACACAATCA 226 AACQ01000039; TCCTCAACATGCAACTTCCCCTCCACCAGCAATTTCTATAAATACCAGTTCAC

ACTCTTTGAAACCATCGGCTAACAAGAAATTTTATCATGATCCACCATCACAT

ATTTTAGTTGATTTCAAATCTGTTΆCTGGTTCCTCAGCTTATCAACCTCCAGG

ATTTGCTGGTATGGTGGCCTATATGTACΆTTCGTAACTCCAAGAAAAGATTAA

CAGAGGCATTTGCCGTACACΆCTAATTCAGTTGAAGATTTTGTTCATGTTGAA

AAAATCAGTGCTGCATTATTTAGΆAATCTTCCTGCCAGTGAAΆTTGAΆAΆCAA

TAGAGTTTACCTTGTTGCTGTTTTAACAGAAGAΆGTTGACTTAAACATTAAAG

GTACGGGGCATACTCCAACAATTAAAAGAGTGAAAAAGGGTGTTGCCGCTGGT

GTAGCTGATATCACCAGAATTTTCCCTAGAGCAGAAGGTTCACTTCAATCTGG

TGAAGCCCATAATTTTTCAATTAAATTGTTTGGTTCTTATTTGAGTAAAAAAG

GTCACAAGAATATGGTGGAAGATCTCAGAGGTCTTAGTAATAATGGTTGGGGT

GAΆCTTGTTGATAGAATTATTGCTGGTTCTAGTCAAGGAGTAGCTGTTAATCC

AAGAGCAGAAAAATTGGTGATCACAGTAAAGGAATTCAAACATCAATTTCAAG

GTAATGTGGCCAATCAATTATCATCTAGTGCACCAATATCTAGAATTAAACCA

ATTTTCTTTGATCCATTGGCGGAAAATTATGAACGTATTTATTTGAAAATGGG

TAAAGTTACTTTATTAGGATCTAATGCCAGAGAAGATTTATTGACATTTGAAG

TCAGTACTCCTAATAATGAATTGATTACCTTTGCCAAAGCTTCCAATCAACAG

GAAAAAAGATATTGGCAATTTATATCTGTCTTCCCCGGTGAATCCATTGGTGA

AATTGTTAAAGTTAATGGAGTTGCATTGAAAAATTCATCTAAAAAATTACCTA

AAGATGATTATATTCTTTTATCATTATATGTTAATGGGGTTCTAGCTGGTGAA

GGAAGATTACTTTATAAATCCGGTAΆTAGATTGGTTGAATTCAATAAGAAAAA

GACTCATACCΆTTGAAATTΆTTTCCGCAACCCATAATGTTCCTATGGCTCATA

TTGAACTTAGTACTGAΆTACGTTGGTAAAGTTTATAATTCTGACGTTTCTATT

GATAATATTTTCCAATACGAAAGATTTTTCCAAAATGGACAAAAAGGTATTGA

TGAACTTTCTAATTCATTGGTTGCTTTCACGAGATTAGATATTGCTCAAGTTG

TCAAATATTTCCCAGAATTATTAAGTTCATTATACGGAATTATTGGATTTTCT

AGTCATCATAGTGGACCTAGTATTGAAATTCTTGAAGATAATACTTTTAAAGC

CGTGATTCATTTGTTAGATACGGTTTTCGGTAΆACAAGATCAATACTTGTATC

TTCTTGATAATTTCATTGCCAAATATAAAAGTCTGAATCAAATTGGTATTTTC

TTATTGACTAAAGTTGAACAAATTTTCAATAGAGCAGGATCAAGTTGGAATTC

GGTTTCTAGATCAGTTTGTCGTGTTCTTTCGΆTTATTTTGAGAATTTCGATTT

TATCAATGAATGCACCAAΆTGAACAAGATTTATATTTACAAACATTGAACAAT

TTATTTAAATCAATTGCTTATCTTCTTACTTTGGATTCCACCAACATGATTGA

TGATCAAGTACTTGTTATGGATATTATTGATTATATTTTTGCCTTTGACGTCA

ATTTCAAAGGATCAGAACTTGTTCAAATAATGATCAATTGTATTGATTCTATT

GGTCTTAAAGGTGTGGGAGTTGATGAACTTAGTATGGAGTCAACTCCGGCTGG

TTCTCGTTCAATTAAAGATCACAAGATCATTATTGGTAAATTATTATTAATTT

TGAGATTACTCAATTCTGATTTAGTCAAAGAGGAAAGTAGTAGATGTATTTTG

ATTCCAAAGGCAATCACATGGGCCGTTGATGTATTCCTTGCCCCTACTGATAT

TGAGGCAACAAGATTGGCATGTAGTGTGCTTAATGCTGCTTGTACAGCTTTAT

GGAATGATGGTGTCATTGGTAAATATCAAGGAGATATGGΆGATTTGTTATTCA

TTGGCCAAGTTTTTACCTGCTATATCGAGAACTTTCATCAAGTATAACAAGTT

TACTAGAGGTAATGGTTCΆTTCAAAAAGAAACGTGTGTTCACTCAATTGTTCC

CATCAACGTATCCTTTCATTGAATTTTCTATTGACCCGGTAGTTAATGATGAA

AGTATGGTTGAAGTTTTAGTTGAACTTGCAATTACATTTTCATTTGTTGCTAG

AGTCGGGAAAGAAGCAGCAGGAAATGAGGGTTATATCACAATTTTGGATTCAC

GAATTGAAAATGATTTTTTCATCCCGGAAAAATATTTGGCATCTGATTTCCAT

GGTGAAGATATACTTACATTACTTTCAGGGATTAGATATATGAGATTGGGTAA

ATATTTCCCTGAAACCAAATGGTATTCAACATATTCTGTCATTATTGAAGGTT

GTTTATGTGCCATTGΆATTGGTGAGACCATTAGTGΆTTATCAATCAATTACCA

GCATTGGATGATTCTGAATCATTTGATAGAACCCTTTGGGGGAACTATCTTAG

AAGTTTGTTTAAATTGGCCGTGTTACCACCTGTGGCAGTCGAGCATTTGTCTG

ATGTTCCAAAAAGTGCTTGTGCCAAAΆTAACCAACGATGTTCGTAAACGGGCT

GCATTTTTAATTAATGAAGCTTGGGATTCTTTAGCTTGGGATGCAΆCTGATGA

AGATATGCTTAGATTTAATTTGAAΆAAATTTGGTGGTTATCAAGTTGAATTTA

TTAATGATGAΆTTTGGAATCTTGCCTGATTTGATGTTACTTGGATTACAAAGA

GATAGTGAATGTCAAAGTGTTGCCATCAAGATTTTATGGTCGATCATGATTTC CGAATATATTTTAAGTGATACTCTTCAAGΆTGTTGAAAGΆCAATGTTTACTTG GTTTACATGAAATTTATCATAATAATTCTTATAAACCAACGTCATTGGATCAA GAAAATTTCATTGAAAGAATGΆAAATGACAGTTAGΆTTGGATAGAGAAGATGA

AGCATTTGATATTATTTATAATTTTATTCAAAATCTTTCATCATTTTTCGGTA

CTCTTAATTATTATATTAGTGTACCATTTGGTCCTGAATATGAΆGAAGATAGA

ATTTTCCATGAAATTAAATTGAAAGCACAAATTAΆAAATGCCGGGAAACCAGA

ACTTTTCAATTCTTATATTCATCAAATGTATGAAΆAGTATCTTTCTCAAAATG

ATTATGTTCAGGCCGCTTTAAGTTTGGAATTACTTGCCAGTACTTΆTTCTTGG

GΆTCATCATATAATTGTΆCCAGCAAGTTTTAGACCAAΆATTCCCAGAACAAAG

TTCATTTGAAΆGAAΆAGAAATATTATTGAAAΆTGATAGCTAATΆATTTTGTTA

AGGGAAATAGTCTTGAAAAAGCAGCTGATACTTATAATGAATTATTAGATTCA

TATAATGAACΆTACTTATGATTTGAAAAGTTTTGCTTATGTTCATAATAAATT

GGCTCAΆTTATATTTGGATATGGAATCTTCAGATΆAATTAACCCCTACATATT

TCAAAGTTGAAGCCATTGGTGGTGGGTTCCCTACTTATTTGACACAAATATCT

CAAATTTTCCAΆGGTTTGCCATTTGAACATΆTCACATCAATTCATGΆACGATT

CCTTAAΆGTTTTCCCTGGTGCTAAAATCATTAGTGATGATGCTGAAGCTATTC

GTCTTAAΆGAAAAΆGCCACTAATGGAAGATATTTATACATTAAAACCGTGGΆA

CCAGTTTATGAGTTTTCTGACAAGTTGATTAATACTTCACTTGGGGTAAGACA

ΆTATGCTAGAAACAΆΆGATTTACGATTTTTCACCAGTTTAAAGAAATTCCCAG

GGGCTACTTCGGTGTTTGATTTATGGACAGAAGAAACTACTTATGAAACATGG

TTATCATTCCCAACTTTAATGAATAGAAGTTTTATTAΆΆGATTCAAAGACCGT

TΆΆATTGTCGCCΆTTGGATAATGCAGTTAGΆACGATAGCTGCCAAGAATGATG

ATTTGATTCAATTAGAAGCGTTTATCΆATGCAGCTCTTAAAGAAAAAACTGAT

TATTCACATTATTTCAATGATTTATCGAGACAATTGGCAGGTACGGTGGATTC

GCCAGTAAATGGAGGGGTTGGCCAATATCGTGCATTTTTCTCCGATAGCAAAT

ATCAAATTAATGAAGAAAGTATTGCTAAAACAGAGTTGTTACGTAATGCATTC

AATGATCTTGCTATTATCTTGTATCGTTGTGTGΆATTTACΆTGGTAGTTTGAT

TGGACTATCGATGAAACTGTCACATCAAGCATTAGTCGAATTGTTTAGAAAGA

ATTTCCAAGAAGAAATTGTTGCTTTACGTTTAGGTGAAGAGGCGΆCAATTACA

GCTCCATCCTCAAGTCGTGTTTCCATTTTCCACAATAAACGTGCTAATGGTTT

AΆTGACTGAACGTGCCAATTCCATTTCAΆACATGTCTGGTGCTGGTTCTACAT

ATTCGGGTTCAAGACTAGCAAGGTCTCCTACTAATGCCTCATCAGTGTCTTCA

AATAATTCATCAATCACTAGATCAGGTAGAGCATCAAΆCACTTCGGGATATCC

TGCAAGTGTTATTCAACCAGGATATACTGGGTTAAAGGGATCATCTCTTAAAA

ATGGTAATGGATCTGTCACTTCTAAATCAATAAACGGATCCGGTAAAACAAAT

GCAATAAATACAAAATGGTAG

YMR029C; ATGCCACCATTCAAATTGAGAAGTAGAAGCAACAGTAGCAGTAGTTCAAATCC 229

AACQ01000069; GCAAACTCAATGGTATAATAATAAAAACCAGAACCAACCCTCAATGTCAGAAC

46438081 CGΆCTTATACGTTACCΆGGCGTTATAAACTATCTAACATCTGAΆTTCACCAAG TTGGAACAΆTTTAAAATTGTAAACAATTTAGAGCGΆAGTGAGATGAAATTCAA AATTAΆGGAATTGGAAGGGGAAΆTTAAAAGTTTAACATTCACAAATAAATTAC AAAAGAAGACAATTGAAAGATTGCAGACAGAAAACAAAAAGCTAAGACTGAGA CTAAACGAAGAAGAAGTCGAAGAAGTCATTATGACTCCATCACCCGAAGAACT ΆGCAAAAATGTCCAAGATTGATTTACAGACGATTAAGAGAACAAGAGΆGCGGT TGGCTAΆTTCGATGAAGGAAATTGTAACATTATTAAAACCACCTACTTTAGAA CCAAGTATTTCATTGGCAΆAAACTAGTAΆAAATACGAATGΆTCTAGAATCTTT ATTGGATAAACCTGAGATCAΆCAAGGCAGACGΆCTTTAATTTCAATGTTAAAC CATATAGTTTTGAAAGCAAGGATTATGAATCACCAGTTAGAAACCCAAGTTCC CTAATTTCCCAGTATTTCAACAGTAATACCGACCTTAAGGAGATTTCTAAAGA AΆAGAAAAAGGCTGAAΆTGGAAAACGACAGTATCGTTGATGATGACGAGATCT TΆGACGCAGAATTAGAΆGATGTTTTGGAAAAAGCCATTTCΆGAAACAAGTGAT TCGGCAACAΆTTGTACTCAATGATGACGATGΆTCCTCTTGCTGΆTTTGAATGA TGATGATTTTTCACTTGATGATAGCCCACAAGAGAGAAGTCAAATCAATAATA ACAACAATAATAATAATGATGATGATGATCTTGATTTTGAAGATAAGCTATCG TCATTCCCACTGTTΆGTΆTCTCCACTGTTAGTACTTCCACTGTTAGTACCTCC TCCGTTAAAATCCCCΆCAGTTACAACCCCCACAGTTAGAACCCCCAGTGTTAG

Claims

WHAT IS CLAIMED IS:

1. A method for treating or inhibiting a fungal infection in a mammal, the method comprising: administering to the mammal a composition comprising cells of a fungal strain or an extract thereof, wherein the cells are genetically modified to have at least one altered filamentation property.

2. The method of claim 1 wherein the cells having the altered filamentation property are hypofilamentous.

3. The method of claim 1 , wherein the cells are genetically modified to alter the expression or activity of at least one polypeptide that regulates filamentation.

4. The method of claim 3, wherein the cells are genetically modified to increase the expression or activity of at least one polypeptide that regulates filamentation.

5. The method of claim 3, wherein the cells are genetically modified to decrease the expression or activity of at least one polypeptide that regulates filamentation.

6. The method of claim 1, wherein the fungal cells are of the same species as the fungus of the fungal infection.

7. The method of claim 1, wherein the fungal cells are of a species other than the fungus of the fungal infection

8. The method of claim 1, wherein the genetic modification of the cells comprises a deletion, insertion, rearrangement or mutation in one or more nucleotides of the cell.

9. The method of claim 8, wherein the deletion, insertion, rearrangement, or mutation causes a deletion, an amino acid change, or a premature truncation of a polypeptide encoded by a nucleic acid in the cell.

10. The method of claim 3, wherein the polypeptide that regulates filamentation is a Crvl polypeptide or a fungal homolog thereof.

11. The method of claim 3, wherein the polypeptide that regulates filamentation is a polypeptide selected from: CdclO, Cdc24, Chk2, Chs3, Cla4, Crkl, Cyrl/Cdc35, Efgl, Erg24, Fas2, Hogl, Hwpl, Ml, Kex2, Nag5, MkI, Pldl, Pmtl, SmI, Sskl, Tpsl, and Vρs34.

12. The method of claim 1, wherein the fungal cells are of the genus Candida.

13. The method of claim 1, wherein the fungal cells are cells of a dimorphic fungus.

14. The method of claim 13, wherein the fungal cells are cells of a dimorphic ascomycete.

15. The method of claim 12, wherein the fungal cells are Candida albicans.

16. The method of claim 1, wherein the composition comprises live fungal cells.

17. The method of claim 1, wherein the composition comprises fungal cells, and wherein at least 80% of the fungal cells of the composition are killed.

18. The method of claim 17, wherein the fungal cells are killed by heat, ultraviolet radiation, mechanical disruption, or chemical inactivation.

19. The method of claim 1, wherein the composition is administered subcutaneously.

20. The method of claim 1, wherein the composition is administered intravenously, intramuscularly, intraperitoneally, intradermally, intraepidermally, or mucosally.

21. The method of claim 1, wherein the composition is administered orally.

22. The method of claim 1 , wherein an immune response is elicited in the mammal.

23. The method of claim 22, wherein the immune response is a protective immune response.

24. The method of claim 1, wherein the composition comprises an adjuvant.

25. The method of claim 1, wherein the composition is administered two or more times to the mammal.

26. The method of claim 22, wherein the immune response includes a cell- mediated immune response.

27. The method of claim 22, wherein the immune response includes a humoral immune response.

28. The method of claim 22, wherein the immune response includes both a cell-mediated immune response and a humoral immune response.

29. The method of claim 22, further comprising evaluating the immune response in the mammal.

30. The method of claim 29, wherein a cell mediated immune response or a humoral immune response is evaluated.

31. The method of claim 29, wherein a cell mediated delayed-type hypersensitivity response is evaluated

32. The method of claim 1 , wherein the mammal is at risk for infection by a fungus before the administering.

33. The method of claim 32, wherein the mammal at risk is immunocompromised or at risk for becoming immunocompromised.

34. The method of claim 32, wherein the mammal has impaired neutrophil function.

35. The method of claim 1, wherein the mammal is suffering from a fungal infection prior to the administering.

36. The method of claim 35, wherein the fungal infection is caused by a fungus of a species that is the same as the species of the fungal cells or extract thereof administered to the mammal.

37. The method of claim 35, wherein the fungal infection is caused by a fungus of a species that is a species other than the species of the fungal cells or extract thereof administered to the mammal.

38. The method of claim 1, wherein the cells have been further genetically modified to increase expression of a cell-surface or secreted molecule, or a portion thereof, relative to a wild-type strain.

39. The method of claim 38, wherein the cell-surface or secreted molecule is a lipid, a carbohydrate, a polypeptide, or a portion thereof.

40. The method of claim 39, wherein the cell-surface molecule is a mannoprotein.

41. The method of claim 40, wherein the mannoprotein is mp58, a homolog of mp58, or a portion of mp58 or the homolog thereof.

42. The method of claim 39, wherein the cell-surface or secreted molecule is selected from the polypeptides of Table 9.

43. The method of claim 1, further comprising administering cells or an extract of cells of a second fungus.

44. The method of claim 43, wherein the cells of the second fungus have been genetically modified to increase the expression of a cell surface or secreted molecule, or a fragment thereof.

45. The method of claim 44, wherein the cell-surface or secreted molecule is a lipid, a carbohydrate, a polypeptide, or a portion thereof.

46. The method of claim 45, wherein the cell surface or secreted molecule is a mannoprotein.

47. The method of claim 46, wherein the mannoprotein is mp58 or a homolog thereof.

48. The method of claim 45, wherein the polypeptide is selected from the polypeptides of Table 9.

49. The method of claim 1 , further comprising isolating a composition comprising antibodies from the mammal.

50. The method of claim 49, further comprising administering the composition comprising antibodies to a second mammal.

51. The method of claim 1, wherein the mammal is chosen from a mouse, human, dog, cat, cow, pig, and horse.

52. The method of claim 51 , wherein the fungal strain is chosen from a strain of one of the following: Aspergillus spp., Candida spp., Cryptococcus spp., Fusarium spp., Histoplasma spp., Pneumocystis spp., Trichophyton spp., Saccharomyces spp., Paracoccidioides spp., and Coccidioides spp.

53. The method of claim 7, wherein the fungal infection is caused by a species selected from one of the following: Aspergillus spp., Candida spp.,

Cryptococcus spp., Fusarium spp., Histoplasma spp., Pneumocystis spp., Trichophyton spp., Saccharomyces spp., Paracoccidioides spp., and Coccidioides spp.

54. The method of claim 3, wherein the polypeptide is a gene product of a gene selected from: SPT3; SSN6; RBFl; RFGl; TUPl; NRGl ; and fungal homologs of SPT3; SSN6; RBFl; RFGl; TUPl; and NRGl.

55. A method for eliciting an immune response to a fungus in a primate, the method comprising: administering to the primate a composition comprising cells of the fungus or an extract of the cells, wherein the cells have decreased expression or activity of CRVl or a fungal homolog of CRVl, thereby inducing an immune response to the fungus in the primate.

56. A method for eliciting an immune response in a mammal, the method comprising: administering to the mammal a composition comprising cells of a Candida species or an extract thereof, wherein the cells are genetically modified to be deficient for expression or activity of at least one polypeptide that regulates filamentation growth, thereby inducing in the mammal an immune response to the Candida strain and a second fungal species selected from: Aspergillus spp., Candida spp., Cryptococcus spp., Fusarium spp., Histoplasma spp., Pneumocystis spp., Trichophyton spp., Paracoccidioides spp., and Coccidioides spp.

57. The method of claim 56 wherein the second fungal species is chosen from: Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, Aspergillus niger,

Candida albicans, Candida ciferrii, Candida dubliniensis, Candida famata, Candida glabrata, Candida guilliermondii, Candida inconspicua, Candida kefyr, Candida krusei, Candida lambica, Candida lipolytica, Candida lusitaniae, Candida norvegensis, Candida par apsilosis, Candida pelliculosa, Candida rugosa, Candida tropicalis, Candida viswanathii, Candida zeylanoides, Coccidioides immitis, Cryptococcus neoformans, Fusarium chlamydosporum, Fusarium oxysporum, Fusarium solani, Histoplasma capsulatum var. capsulatum, Histoplasma capsulatum var. duboisii, Paracoccidioides brasiliensis, Pneumocystis carinii, Trichophyton rubrum,

58. A composition comprising:

(a) cells of a fungus or an extract of the cells, wherein the cells are of a strain genetically modified to have at least one altered filamentation property; and

(b) a pharmaceutically acceptable carrier.

59. The composition of claim 58, wherein the cells are genetically modified to reduce expression or activity of at least one polypeptide that regulates filamentation.

60. The composition of claim 59, wherein the cells are genetically modified to reduce expression or activity of a Crvl polypeptide or a fungal homolog thereof.

61. The composition of claim 59, wherein the cells have been further genetically modified to increase expression of a cell surface or secreted molecule, or a portion thereof, relative to a wild-type strain.

62. The composition of claim 61, wherein the cell-surface or secreted molecule is a lipid, a carbohydrate, a polypeptide, or a portion thereof.

63. The composition of claim 62 wherein the cell-surface or secreted molecule is a mannoprotein.

64. The composition of claim 63, wherein the mannoprotein is mp58, a homolog thereof, or a portion of mp58 or the homolog thereof.

65. The composition of claim 58, further comprising an adjuvant.

66. The composition of claim 58, further comprising an extract of cells or cells of a second fungus.

67. The composition of claim 66, wherein the cells of the second fungus are genetically modified to increase expression of cell-surface or secreted molecule, or a fragment thereof, relative to a wild-type strain.

68. The composition of claim 67, wherein the molecule is a mannoprotein.

69. The composition of claim 68, wherein the mannoprotein is mp58.

70. A method for treating or inhibiting a fungal infection in a mammal, the method comprising: administering to the mammal a composition comprising cells of a fungus or an extract thereof, wherein the cells are genetically modified to have increased production of a cell surface or secreted molecule, thereby treating or inhibiting the fungal infection in the mammal.

71. The method of claim 70, wherein the fungal cells are of the same genus as the fungus of the fungal infection.

72. The method of claim 71, wherein the fungal cells are of the same species as the fungus of the fungal infection.

73. The method of claim 70, wherein the fungal cells are of a genus other than the genus of the fungus of the fungal infection

74. The method of claim 70, wherein the fungal cells are of the genus Candida.

75. The method of claim 70, wherein the fungal cells are cells of a dimorphic fungus.

76. The method of claim 75, wherein the fungal cells are cells of a dimorphic ascomycete.

77. The method of claim 74, wherein the fungal cells are Candida albicans.

78. The method of claim 70, wherein the composition comprises live fungal cells.

79. The method of claim 70, wherein the composition is administered subcutaneously.

80. The method of claim 70, wherein the composition is administered intravenously, intramuscularly, intraperitoneally, intradermally, intraepidermally, or mucosally.

81. The method of claim 70, wherein the composition is administered orally.

82. The method of claim 70, wherein an immune response is elicited in the mammal.

83. The method of claim 82 wherein the immune response is a protective immune response.

84. The method of claim 70, wherein the composition comprises an adjuvant.

85. The method of claim 70, wherein the composition is administered two or more times to the mammal.

86. The method of claim 82, wherein the immune response includes a cell- mediated immune response.

87. The method of claim 82, wherein the immune response includes a humoral immune response.

88. The method of claim 82, wherein the immune response includes both a cell-mediated immune response and a humoral immune response.

89. The method of claim 82, further comprising evaluating the immune response in the mammal.

90. The method of claim 89, wherein a cell mediated immune response or a humoral immune response is evaluated.

91. The method of claim 89, wherein a cell mediated delayed-type hypersensitivity response is evaluated

92. The method of claim 70, wherein the mammal is at risk for infection by a fungus before the administering.

93. The method of claim 92, wherein the mammal at risk is immunocompromised or at risk for becoming immunocompromised.

94. The method of claim 92, wherein the mammal has impaired neutrophil function.

95. The method of claim 70, wherein the mammal is suffering from a fungal infection prior to the administering.

96. The method of claim 95, wherein the fungal infection caused by a fungus of a genus that is the same as the genus of the fungal cells or extract thereof administered to the mammal.

97. The method of claim 96, wherein the fungal infection is caused by a fungus of a species that is the same as the species of fungal cells or extract thereof administered to the mammal.

98. The method of claim 95, wherein the fungal infection is caused by a genus or species other than the genus or species of fungus cells or extract thereof that is administered to the mammal.

99. The method of claim 70, wherein the cell-surface or secreted molecule is a lipid, a carbohydrate, a polypeptide, or a portion thereof.

100. The method of claim 70 wherein the cell-surface or secreted molecule is a mannoprotein.

101. The method of claim 100, wherein the mannoprotein is mp58, a honiolog thereof, or a portion of mp58 or the homolog thereof.

102. The method of claim 99, wherein the cell-surface or secreted molecule is a polypeptide selected from the polypeptides of Table 9.

103. Use of the composition of any of claims 58-69 in the manufacture of a medicament for treating or inhibiting a fungal infection in a mammal.

104. Use of the composition of any of claims 58-69 for treating or inhibiting a fungal infection in a mammal.