PL3693009T3 - Nowy kompleks zawierający peptyd penetrujący komórkę, cargo i agonistę peptydu tlr do leczenia raka jelita grubego - Google Patents

Nowy kompleks zawierający peptyd penetrujący komórkę, cargo i agonistę peptydu tlr do leczenia raka jelita grubego

Info

Publication number
PL3693009T3
PL3693009T3 PL19219165.8T PL19219165T PL3693009T3 PL 3693009 T3 PL3693009 T3 PL 3693009T3 PL 19219165 T PL19219165 T PL 19219165T PL 3693009 T3 PL3693009 T3 PL 3693009T3
Authority
PL
Poland
Prior art keywords
cargo
treatment
colorectal cancer
cell penetrating
peptide
Prior art date
Application number
PL19219165.8T
Other languages
English (en)
Inventor
Madiha DEROUAZI
Elodie BELNOUE
Original Assignee
Amal Therapeutics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amal Therapeutics Sa filed Critical Amal Therapeutics Sa
Publication of PL3693009T3 publication Critical patent/PL3693009T3/pl

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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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    • A61K39/0011—Cancer antigens
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    • A61K38/10—Peptides having 12 to 20 amino acids
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
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    • C—CHEMISTRY; METALLURGY
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    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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PL19219165.8T 2015-03-16 2016-03-16 Nowy kompleks zawierający peptyd penetrujący komórkę, cargo i agonistę peptydu tlr do leczenia raka jelita grubego PL3693009T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2015000580 2015-03-16
EP2015002244 2015-11-09

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PL3693009T3 true PL3693009T3 (pl) 2024-06-10

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PL19219165.8T PL3693009T3 (pl) 2015-03-16 2016-03-16 Nowy kompleks zawierający peptyd penetrujący komórkę, cargo i agonistę peptydu tlr do leczenia raka jelita grubego
PL16711529T PL3270955T3 (pl) 2015-03-16 2016-03-16 Nowy kompleks zawierający peptyd penetrujący komórkę, cargo i agonistę peptydu tlr do leczenia raka jelita grubego
PL16713731T PL3270957T3 (pl) 2015-03-16 2016-03-16 Nowy kompleks zawierający peptyd penetrujący komórkę, cargo i agonistę peptydu tlr do leczenia glioblastomy

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Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016146143A1 (en) 2015-03-16 2016-09-22 Amal Therapeutics Sa Cell penetrating peptides and complexes comprising the same
WO2017106332A1 (en) 2015-12-14 2017-06-22 X4 Pharmaceuticals, Inc. Methods for treating cancer
JP6864296B2 (ja) 2015-12-14 2021-04-28 エックス４ ファーマシューティカルズ， インコーポレイテッド がんを処置する方法
PL3393468T3 (pl) 2015-12-22 2023-01-23 X4 Pharmaceuticals, Inc. Metody leczenia niedoboru odporności
LT3429618T (lt) 2016-03-16 2024-05-10 Amal Therapeutics Sa Imuninės sistemos patikros taško moduliatoriaus ir komplekso, apimančio į ląsteles prasiskverbiantį peptidą, krovinį ir tlr peptido agonistą, derinys, skirtas naudoti medicinoje
CA3019394A1 (en) 2016-04-08 2017-10-12 X4 Pharmaceuticals, Inc. Methods for treating cancer
JP7084624B2 (ja) 2016-06-21 2022-06-15 エックス４ ファーマシューティカルズ， インコーポレイテッド Ｃｘｃｒ４阻害剤およびその使用
ES2870920T3 (es) 2016-06-21 2021-10-28 X4 Pharmaceuticals Inc Inhibidores de CXCR4 y usos de los mismos
JP6994767B2 (ja) 2016-06-21 2022-01-14 エックス４ ファーマシューティカルズ， インコーポレイテッド Ｃｘｃｒ４阻害剤およびその使用
CN109963585B (zh) * 2016-09-21 2024-10-15 阿尔勒治疗公司 包括细胞穿透肽、多表位和tlr肽激动剂的用于治疗癌症的融合物
EP3522917A2 (en) 2016-10-07 2019-08-14 Enterome S.A. Microbiota sequence variants of tumor-related antigenic epitopes
KR102686875B1 (ko) 2016-10-07 2024-07-19 엔터롬 에스.에이. 암 치료를 위한 면역원성 화합물
EP3522916A2 (en) 2016-10-07 2019-08-14 Enterome S.A. Immunogenic compounds for cancer therapy
EP3526259A4 (en) * 2016-10-13 2020-06-17 Dana-Farber Cancer Institute, Inc. COMPOSITIONS AND METHODS FOR PREDICTING RESPONSE AND RESISTANCE TO CTLA4 BLOCKAGE IN MELANOMA USING GENE EXPRESSION SIGNATURE
KR101875055B1 (ko) * 2016-10-19 2018-07-06 연세대학교 원주산학협력단 융합 단백질 및 그의 용도
KR102007203B1 (ko) * 2016-10-20 2019-08-05 연세대학교 원주산학협력단 융합 단백질 및 그의 용도
EP3532505A4 (en) * 2016-10-25 2019-12-25 Urogen Pharma Ltd. BODY CAVES IMMUNODULATING TREATMENTS
US11229668B2 (en) * 2017-02-07 2022-01-25 Nantcell, Inc. Maximizing T-cell memory and compositions and methods therefor
CA3057715A1 (en) 2017-04-04 2018-10-11 Avidea Technologies, Inc. Peptide-based vaccines, methods of manufacturing, and uses thereof for inducing an immune response
US11433128B2 (en) * 2017-04-07 2022-09-06 Tianxin Wang Cell surface anchoring antigen conjugates to treat cancer
US12121573B2 (en) 2019-07-14 2024-10-22 Tianxin Wang Methods and agents including STING agonist to treat tumor
WO2018197926A1 (en) * 2017-04-26 2018-11-01 Robert Penchovsky Methods for creating novel antibacterial agents using chimeric antisense oligonucleotides
CN110996952A (zh) * 2017-06-21 2020-04-10 X4 制药有限公司 用于治疗癌症的方法
WO2019134018A1 (en) * 2018-01-05 2019-07-11 Telethon Kids Institute Vaccine conjugates and uses thereof
WO2019160780A1 (en) * 2018-02-16 2019-08-22 Wang tian xin Methods and agents to treat tumor cells and cancer
CA3094262A1 (en) 2018-04-11 2019-10-17 Enterome S.A. Antigenic peptides for prevention and treatment of cancer
EP3789491B1 (en) * 2018-05-02 2025-04-16 Kansai Medical University Educational Corporation Peptide and use therefor
EP3566718A1 (en) 2018-05-07 2019-11-13 Universitätsmedizin der Johannes Gutenberg-Universität Mainz A pharmazeutical combination (treg depleting agent, checkpoint inhibitor, tlr9 agonist) for use in the treatment of cancer
CN112703198B (zh) 2018-07-11 2025-05-30 布里格姆妇女医院 用于跨血脑屏障递送试剂的方法和组合物
EP3829652A4 (en) * 2018-08-01 2022-05-11 University of Maryland, Baltimore MODULATION OF MTORC1 ACTIVITY AND AUTOPHAGY BY CIB2-RHEB INTERACTION
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use
EP3876956A4 (en) * 2018-11-08 2022-12-28 The Regents of The University of California SYSTEMS AND METHODS FOR TARGETING CANCER CELLS
JP7520003B2 (ja) 2018-11-16 2024-07-22 ブリストル－マイヤーズ スクイブ カンパニー 抗ｎｋｇ２ａ抗体およびその使用
KR102351041B1 (ko) * 2018-12-19 2022-01-13 한국화학연구원 인간 lrrc24 단백질 유래 세포막 투과 도메인
WO2020130547A1 (ko) * 2018-12-19 2020-06-25 한국화학연구원 인간 엘알알씨24 단백질 유래 세포막 투과 도메인
WO2020130546A1 (ko) * 2018-12-19 2020-06-25 한국화학연구원 인간 씨엘케이2 단백질 유래 세포막 투과 도메인
WO2020130548A1 (ko) * 2018-12-19 2020-06-25 한국화학연구원 인간 쥐피에이티씨에치4 단백질 유래 세포막 투과 도메인
WO2020146906A2 (en) * 2019-01-12 2020-07-16 The Methodist Hospital Self-assembled peptide nanoparticle and use thereof
CN109859795A (zh) * 2019-02-20 2019-06-07 成都分迪科技有限公司 泛素化降解目标蛋白质的数据库
WO2020198734A1 (en) * 2019-03-28 2020-10-01 The Penn State Research Foundation Methods, compositions relating to treatment of cancer
US11339190B2 (en) 2020-04-21 2022-05-24 Rush University Medical Center Peptides for the treatment of covid-19
US11667678B2 (en) 2019-04-21 2023-06-06 Rush University Medical Center Peptides for the treatment of COVID-19
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
EP3966316A4 (en) 2019-05-10 2023-01-25 The Regents of The University of California MODIFIED PLURIPOTENT CELLS
EP3827840A1 (en) * 2019-11-29 2021-06-02 Academisch Ziekenhuis Leiden h.o.d.n. LUMC Teipp peptide variant and uses thereof
CA3167290A1 (en) * 2020-01-10 2021-07-15 The Brigham And Women's Hospital, Inc. Methods and compositions for delivery of immunotherapy agents across the blood-brain barrier to treat brain cancer
CA3171250A1 (en) 2020-03-10 2021-09-16 E. Lynne KELLEY Methods for treating neutropenia
KR102484312B1 (ko) * 2020-05-14 2023-01-02 한국화학연구원 고효능 사스 코로나바이러스 2 항원 및 이를 포함하는 백신 조성물
KR20230012559A (ko) 2020-05-19 2023-01-26 베링거 인겔하임 인터내셔날 게엠베하 암 치료를 위한 결합 분자
WO2021246666A1 (ko) * 2020-06-04 2021-12-09 가톨릭대학교 산학협력단 플라젤린으로부터 유도된 tlr5 작용제를 유효성분으로 포함하는 항암제 조성물
AU2021294322A1 (en) * 2020-06-26 2023-02-02 National Breast Cancer Coalition Breast cancer vaccine
TW202227126A (zh) 2020-09-14 2022-07-16 德商百靈佳殷格翰國際股份有限公司 異源初免加強疫苗
KR102556731B1 (ko) * 2020-09-29 2023-07-21 주식회사 젠센 단백질 수송 도메인, 이를 포함하는 융합 화합물 및 이 융합 화합물을 포함하는 약학 조성물
JP2023545178A (ja) * 2020-10-14 2023-10-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｓｔｉｎｇアゴニストと、細胞透過性ペプチド、カーゴ、及びｔｌｒペプチドアゴニストを含む複合体との組合せ
WO2022087018A1 (en) * 2020-10-19 2022-04-28 G1 Therapeutics, Inc. Improved fluorouracil-based multi-agent chemotherapy for treatment of metastatic colorectal cancer
CN113817677B (zh) * 2021-09-29 2023-08-18 四川大学 泛酸或其衍生物与α-D-葡萄糖-1,6-二磷酸或其衍生物在促进DC迁移中的用途
WO2023059687A1 (en) * 2021-10-06 2023-04-13 Whispergenics, Inc. Triple drug combination (metformin, simvastatin, digoxin) for targeted treatment of cancers
KR102514849B1 (ko) * 2021-10-28 2023-03-28 전남대학교산학협력단 수지상 세포를 표적하는 신규한 펩타이드, 및 이를 포함하는 암 치료용 조성물
PE20242221A1 (es) 2022-03-16 2024-11-19 Boehringer Ingelheim Int Antigenos tumorales, compuestos que comprenden los antigenos tumorales kras, tpx2 o aurka y usos de los mismos
EP4507727A1 (en) * 2022-04-13 2025-02-19 The Regents of the University of California Immune cell inhibition by immune checkpoint engagers
FR3143031A1 (fr) * 2022-12-08 2024-06-14 Université Grenoble Alpes Nouveaux peptides et leur utilisation en tant que transporteurs pour l’internalisation de molécules d’intérêt dans des cellules cibles
WO2024197792A1 (en) * 2023-03-31 2024-10-03 Beijing University Of Chinese Medicine A complex comprising a cell penetrating peptide and a copi sorting inhibitor and uses thereof
CN119925590A (zh) * 2025-04-08 2025-05-06 北京华诺泰生物医药科技有限公司 一种mpl复合佐剂及其制备方法和应用

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5851795A (en) 1991-06-27 1998-12-22 Bristol-Myers Squibb Company Soluble CTLA4 molecules and uses thereof
US6479055B1 (en) 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
FR2728904B1 (fr) 1995-01-04 1997-03-14 Pasteur Institut Reactif peptidique permettant de detecter une infection primaire a virus d'epstein-barr par recherche des anticorps correspondants, et procede d'utilisation de ce reactif
US5855887A (en) 1995-07-25 1999-01-05 The Regents Of The University Of California Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
US6051227A (en) 1995-07-25 2000-04-18 The Regents Of The University Of California, Office Of Technology Transfer Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US5811097A (en) 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
WO1998042752A1 (en) 1997-03-21 1998-10-01 Brigham And Women's Hospital Inc. Immunotherapeutic ctla-4 binding peptides
US6258782B1 (en) 1998-05-20 2001-07-10 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
US7109003B2 (en) 1998-12-23 2006-09-19 Abgenix, Inc. Methods for expressing and recovering human monoclonal antibodies to CTLA-4
SG143018A1 (en) 1998-12-23 2008-06-27 Pfizer Human monoclonal antibodies to ctla-4
EE05627B1 (et) 1998-12-23 2013-02-15 Pfizer Inc. CTLA-4 vastased inimese monoklonaalsed antikehad
US6750008B1 (en) 1999-07-09 2004-06-15 Trimeris, Inc. Methods and compositions for inhibition of membrane fusion-associated events, including HIV transmission
EP1212422B1 (en) 1999-08-24 2007-02-21 Medarex, Inc. Human ctla-4 antibodies and their uses
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
US7034121B2 (en) 2000-01-27 2006-04-25 Genetics Institue, Llc Antibodies against CTLA4
KR100919916B1 (ko) 2000-02-23 2009-10-07 글락소스미스클라인 바이오로지칼즈 에스.에이. 종양 특이적 동물 단백질
AU2002220265A1 (en) 2000-11-03 2002-05-15 University Of Vermont And State Agricultural College Compositions for inhibiting grb7
US20060222656A1 (en) 2005-04-01 2006-10-05 University Of Maryland, Baltimore MAGE-A3/HPV 16 peptide vaccines for head and neck cancer
AUPR593101A0 (en) 2001-06-26 2001-07-19 Council Of The Queensland Institute Of Medical Research, The Cytomegalovirus t cell epitopes
US7892559B2 (en) 2002-01-30 2011-02-22 Survac Aps Survivin-derived peptides and use thereof
GB0218821D0 (en) 2002-08-13 2002-09-18 Glaxosmithkline Biolog Sa Novel compositions
PT1558648E (pt) 2002-10-17 2012-04-23 Genmab As Anticorpos monoclonais humanos contra cd20
ATE552011T1 (de) * 2003-10-15 2012-04-15 Ist Superiore Sanita Kolorektal-karzinom-antigen
EP1768698A4 (en) 2004-06-17 2009-01-28 Medimmune Inc IMMUNOGENIC COMPOSITIONS COMPRISING HMGB1 POLYPEPTIDES
WO2006003179A2 (en) 2004-07-01 2006-01-12 Novo Nordisk A/S Antibodies binding to receptors kir2dl1, -2, 3 but not kir2ds4 and their therapeutic use
ES2523172T3 (es) * 2005-02-04 2014-11-21 Survac Aps Vacuna de péptido de survivina
ES2291071B1 (es) 2005-06-13 2009-03-16 Proyecto De Biomedicina Cima, S.L. Agentes y metodos basados en el uso del dominio eda de la fibronectina.
NZ594510A (en) 2006-12-27 2012-06-29 Harvard College Compositions and methods for the treatment of infections and tumors
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
NZ600758A (en) 2007-06-18 2013-09-27 Merck Sharp & Dohme Antibodies to human programmed death receptor pd-1
SI2183361T1 (sl) * 2007-07-27 2015-09-30 Immatics Biotechnologies Gmbh Nova imunoterapija proti nevronalnim in možganskim tumorjem
KR20100063048A (ko) 2007-07-31 2010-06-10 더 존스 홉킨스 유니버시티 신생물성 또는 감염성 장애의 면역예방 또는 면역치료를 위한 폴리펩티드-핵산 접합체
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
EP2278994A4 (en) * 2008-04-25 2012-01-18 Inst Systems Biology Flagellin POLYPEPTIDE VACCINES
NO2119726T3 (pl) 2008-05-14 2015-05-23
CA2728739C (en) 2008-06-20 2017-07-11 Duke University Use of human cytomegalovirus antigens to enhance immune responses to cancer cells
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
KR101040281B1 (ko) 2008-08-22 2011-06-10 가톨릭대학교 산학협력단 Ｔａｔ-항원 융합단백질과 아쥬번트를 포함하는 백신 조성물
US8074880B2 (en) 2008-12-01 2011-12-13 Research In Motion Limited Method, system and mobile device employing enhanced fingerprint authentication
US8217149B2 (en) 2008-12-09 2012-07-10 Genentech, Inc. Anti-PD-L1 antibodies, compositions and articles of manufacture
US9707285B2 (en) 2009-03-16 2017-07-18 Turnstone Limited Partnership Vaccination methods
SG176220A1 (en) 2009-05-27 2011-12-29 Glaxosmithkline Biolog Sa Casb7439 constructs
CA2769473A1 (en) 2009-07-31 2011-02-03 N.V. Organon Fully human antibodies to btla
CA2772204A1 (en) 2009-08-31 2011-03-03 Amplimmune, Inc. Methods and compositions for the inhibition of transplant rejection
EP2476440B1 (en) * 2009-09-11 2017-08-02 Proyecto de Biomedicina Cima, S.L. Therapeutic compositions for the treatment of hpv-induced diseases
EP2480568B1 (en) 2009-09-23 2016-04-20 Université Paris Descartes Polypeptides and nucleic acids for treating erbb2-dependent cancers
LT3279215T (lt) 2009-11-24 2020-04-10 Medimmune Limited Tiksliniai surišantys agentai prieš b7-h1
WO2011101332A1 (en) 2010-02-16 2011-08-25 Proyecto De Biomedicina Cima, S.L. Compositions based on the fibronectin extracellular domain a for the treatment of melanoma
PH12012501751A1 (en) 2010-03-04 2012-11-12 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
EP2563399B1 (fr) 2010-04-26 2014-06-11 Université Joseph Fourier Utilisation de peptides comme transporteurs destines a l'internalisation de molecules d'interet dans des cellules cibles
US9314516B2 (en) 2010-05-04 2016-04-19 Cassian Yee Conditional superagonist CTL ligands for the promotion of tumor-specific CTL responses
CN107648604A (zh) 2010-07-30 2018-02-02 库瑞瓦格股份公司 聚合物载体运载物复合物及聚合物载体的用途
AU2011293522B2 (en) 2010-08-24 2015-03-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Interleukin-13 receptor alpha 2 peptide-based brain cancer vaccines
WO2012035558A2 (en) * 2010-09-14 2012-03-22 Council Of Scientific & Industrial Research A synthetic immunogen useful for generating long lasting immunity and protection against pathogens
US9555074B2 (en) * 2010-10-08 2017-01-31 Regents Of The University Of Minnesota Annexin II compositions
KR101760464B1 (ko) * 2010-10-13 2017-07-24 사회복지법인 삼성생명공익재단 교모세포종의 진단 또는 예후 예측용 바이오 마커 및 그 용도
CN103476458B (zh) 2011-01-10 2017-02-15 克利夫兰生物实验室公司 Toll样受体激动剂治疗癌症的用途
US9187534B2 (en) 2011-03-11 2015-11-17 Universite De Geneve Multi-epitopic vaccine
TWI454478B (zh) * 2011-05-13 2014-10-01 Academia Sinica 類鐸受體-２ 增效劑及其用於刺激免疫反應之用途
US8841418B2 (en) 2011-07-01 2014-09-23 Cellerant Therapeutics, Inc. Antibodies that specifically bind to TIM3
US8819679B2 (en) 2011-07-28 2014-08-26 International Business Machines Corporation Methods and systems for on-boarding applications to a cloud
CA2845536A1 (en) 2011-08-15 2013-02-21 Amplimmune, Inc. Anti-b7-h4 antibodies and their uses
ES2861435T3 (es) 2011-11-03 2021-10-06 Univ Pennsylvania Composiciones específicas de B7-H4 aisladas y métodos de uso de las mismas
US20140314667A1 (en) * 2011-11-16 2014-10-23 Amgen Inc. Methods of treating epidermal growth factor deletion mutant viii related disorders
WO2013113326A1 (en) 2012-01-31 2013-08-08 Curevac Gmbh Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
US9597393B2 (en) * 2012-02-09 2017-03-21 Av Therapeutics, Inc. Synthetic toll-like receptor-4 (TLR-4) agonist peptides
AU2013289372B2 (en) 2012-07-13 2017-11-02 S-Target Therapeutics Gmbh Immunoregulatory vaccine
WO2014041505A1 (en) * 2012-09-13 2014-03-20 Universite De Geneve Cell penetrating peptides
JP6374388B2 (ja) 2012-09-21 2018-08-15 インテンシティ セラピューティクス, インク.Intensity Therapeutics, Inc. 癌の治療方法
US20150290306A1 (en) * 2012-10-29 2015-10-15 David E. Anderson Compositions and methods for diagnosis and treatment of malignant gliomas
AU2014248711A1 (en) * 2013-03-13 2015-09-10 Neostem Oncology, Llc Individualized high purity colon carcinoma stem cells, methods and use of the same
CN106061981A (zh) * 2013-11-06 2016-10-26 索尔斯蒂斯生物有限公司 具有二硫化物基团的多核苷酸构建体
ES2928331T3 (es) * 2013-11-13 2022-11-17 Univ Minnesota Composiciones de variantes de anexina II y métodos
AU2014374020A1 (en) * 2014-01-02 2016-08-18 Memorial Sloan Kettering Cancer Center Determinants of cancer response to immunotherapy
WO2015188197A2 (en) * 2014-06-06 2015-12-10 Solstice Biologics, Ltd. Polynucleotide constructs having bioreversible and non-bioreversible groups
US11111472B2 (en) 2014-10-31 2021-09-07 Massachusetts Institute Of Technology Delivery of biomolecules to immune cells
KR20170080697A (ko) 2014-11-13 2017-07-10 더 존스 홉킨스 유니버시티 관문 차단 및 미소부수체 불안정성
WO2016146143A1 (en) 2015-03-16 2016-09-22 Amal Therapeutics Sa Cell penetrating peptides and complexes comprising the same
BR102015025502B1 (pt) 2015-04-30 2022-06-21 Aegerion Pharmaceuticals, Inc Composição de lomitapida, tablete, produto de lomitapida, métodos para analisar uma composição de amostra de lomitapida e para determinar uma quantidade de uma impureza em uma amostra da composição
WO2017002345A1 (ja) 2015-06-29 2017-01-05 パナソニックＩｐマネジメント株式会社 冷蔵庫
GB201520592D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
US10626377B2 (en) 2016-01-08 2020-04-21 Replimune Limited Use of an oncolytic virus for the treatment of cancer
KR20190038470A (ko) 2016-01-11 2019-04-08 턴스톤 리미티드 파트너쉽 온콜리틱 바이러스 및 체크포인트 억제제 병용 요법
LT3429618T (lt) * 2016-03-16 2024-05-10 Amal Therapeutics Sa Imuninės sistemos patikros taško moduliatoriaus ir komplekso, apimančio į ląsteles prasiskverbiantį peptidą, krovinį ir tlr peptido agonistą, derinys, skirtas naudoti medicinoje
AU2017264901A1 (en) 2016-05-09 2018-12-06 Turnstone Limited Partnership Combination prime: boost therapy
PL417980A1 (pl) 2016-07-16 2018-01-29 Univ Warszawski Nowe fosfotriazolowe analogi kapu końca 5' mRNA, kompozycja je zawierająca, cząsteczka RNA je zawierająca, ich zastosowania i sposób syntezy cząsteczki RNA, białka i peptydu
US11052149B2 (en) 2016-09-19 2021-07-06 The University Of North Carolina At Chapel Hill Methods and compositions for inducing an immune response
CN109963585B (zh) 2016-09-21 2024-10-15 阿尔勒治疗公司 包括细胞穿透肽、多表位和tlr肽激动剂的用于治疗癌症的融合物
CA3058807A1 (en) 2017-04-03 2018-10-11 Neon Therapeutics, Inc. Protein antigens and uses thereof
CN111936156A (zh) 2018-02-02 2020-11-13 诺华股份有限公司 用于治疗癌症的STING激动剂和IL-15/IL15-Ra的组合
JP2021529173A (ja) 2018-06-20 2021-10-28 イエール ユニバーシティ Ｒｉｇ−ｉアゴニストおよびそれを使用した処置
WO2020010451A1 (en) 2018-07-10 2020-01-16 Trillium Therapeutics Inc. Heteroaromatic-fused imidazolyl amides, compositions and uses thereof as sting agonists
TW202227126A (zh) 2020-09-14 2022-07-16 德商百靈佳殷格翰國際股份有限公司 異源初免加強疫苗
JP2023545178A (ja) 2020-10-14 2023-10-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｓｔｉｎｇアゴニストと、細胞透過性ペプチド、カーゴ、及びｔｌｒペプチドアゴニストを含む複合体との組合せ

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