JP2017503480A5 - - Google Patents
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- JP2017503480A5 JP2017503480A5 JP2016534706A JP2016534706A JP2017503480A5 JP 2017503480 A5 JP2017503480 A5 JP 2017503480A5 JP 2016534706 A JP2016534706 A JP 2016534706A JP 2016534706 A JP2016534706 A JP 2016534706A JP 2017503480 A5 JP2017503480 A5 JP 2017503480A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- her2
- construct
- polypeptide
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 106
- 229920001184 polypeptide Polymers 0.000 claims 104
- 102000004196 processed proteins & peptides Human genes 0.000 claims 104
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 74
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 74
- 239000000427 antigen Substances 0.000 claims 62
- 102000036639 antigens Human genes 0.000 claims 62
- 108091007433 antigens Proteins 0.000 claims 62
- 210000004027 cell Anatomy 0.000 claims 62
- 210000004881 tumor cell Anatomy 0.000 claims 30
- 102100024952 Protein CBFA2T1 Human genes 0.000 claims 27
- 206010028980 Neoplasm Diseases 0.000 claims 24
- 125000003275 alpha amino acid group Chemical group 0.000 claims 17
- 230000004048 modification Effects 0.000 claims 17
- 238000012986 modification Methods 0.000 claims 17
- 206010006187 Breast cancer Diseases 0.000 claims 12
- 208000026310 Breast neoplasm Diseases 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 229960002087 pertuzumab Drugs 0.000 claims 9
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 229960000575 trastuzumab Drugs 0.000 claims 8
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 201000002528 pancreatic cancer Diseases 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 206010033128 Ovarian cancer Diseases 0.000 claims 6
- 238000003364 immunohistochemistry Methods 0.000 claims 6
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 6
- 229930012538 Paclitaxel Natural products 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 229960004562 carboplatin Drugs 0.000 claims 5
- 190000008236 carboplatin Chemical compound 0.000 claims 5
- 208000020816 lung neoplasm Diseases 0.000 claims 5
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 5
- 229960001592 paclitaxel Drugs 0.000 claims 5
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 5
- 239000013598 vector Substances 0.000 claims 5
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 4
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 4
- 229960004316 cisplatin Drugs 0.000 claims 4
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 4
- 229960003668 docetaxel Drugs 0.000 claims 4
- 206010017758 gastric cancer Diseases 0.000 claims 4
- 208000014829 head and neck neoplasm Diseases 0.000 claims 4
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- 206010008342 Cervix carcinoma Diseases 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 229930126263 Maytansine Natural products 0.000 claims 3
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 claims 3
- 206010034811 Pharyngeal cancer Diseases 0.000 claims 3
- 208000000453 Skin Neoplasms Diseases 0.000 claims 3
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 3
- 201000010881 cervical cancer Diseases 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 102000015694 estrogen receptors Human genes 0.000 claims 3
- 108010038795 estrogen receptors Proteins 0.000 claims 3
- 229960002949 fluorouracil Drugs 0.000 claims 3
- 210000004293 human mammary gland Anatomy 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- WKPWGQKGSOKKOO-RSFHAFMBSA-N maytansine Chemical compound CO[C@@H]([C@@]1(O)C[C@](OC(=O)N1)([C@H]([C@@H]1O[C@@]1(C)[C@@H](OC(=O)[C@H](C)N(C)C(C)=O)CC(=O)N1C)C)[H])\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 WKPWGQKGSOKKOO-RSFHAFMBSA-N 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 230000004083 survival effect Effects 0.000 claims 3
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 3
- 206010046766 uterine cancer Diseases 0.000 claims 3
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 2
- 108010012934 Albumin-Bound Paclitaxel Proteins 0.000 claims 2
- 101100402572 Arabidopsis thaliana MS5 gene Proteins 0.000 claims 2
- 101150029707 ERBB2 gene Proteins 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims 2
- 206010061968 Gastric neoplasm Diseases 0.000 claims 2
- 101000882584 Homo sapiens Estrogen receptor Proteins 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 2
- 206010029098 Neoplasm skin Diseases 0.000 claims 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 2
- 229960004679 doxorubicin Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229960001904 epirubicin Drugs 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
- 229960005277 gemcitabine Drugs 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 239000000710 homodimer Substances 0.000 claims 2
- 206010073095 invasive ductal breast carcinoma Diseases 0.000 claims 2
- 229960004768 irinotecan Drugs 0.000 claims 2
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 208000037841 lung tumor Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 208000021039 metastatic melanoma Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 201000002743 tongue squamous cell carcinoma Diseases 0.000 claims 2
- 208000025421 tumor of uterus Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 208000024719 uterine cervix neoplasm Diseases 0.000 claims 2
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010055113 Breast cancer metastatic Diseases 0.000 claims 1
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 1
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
- 230000004544 DNA amplification Effects 0.000 claims 1
- 208000006402 Ductal Carcinoma Diseases 0.000 claims 1
- MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 claims 1
- 101150054472 HER2 gene Proteins 0.000 claims 1
- 101000945318 Homo sapiens Calponin-1 Proteins 0.000 claims 1
- 101000652736 Homo sapiens Transgelin Proteins 0.000 claims 1
- 102000009490 IgG Receptors Human genes 0.000 claims 1
- 108010073807 IgG Receptors Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 208000005726 Inflammatory Breast Neoplasms Diseases 0.000 claims 1
- 206010021980 Inflammatory carcinoma of the breast Diseases 0.000 claims 1
- 102100020870 La-related protein 6 Human genes 0.000 claims 1
- 108050008265 La-related protein 6 Proteins 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 102100025803 Progesterone receptor Human genes 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 102220497176 Small vasohibin-binding protein_T47D_mutation Human genes 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 102100031013 Transgelin Human genes 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 1
- KYIKRXIYLAGAKQ-UHFFFAOYSA-N abcn Chemical compound C1CCCCC1(C#N)N=NC1(C#N)CCCCC1 KYIKRXIYLAGAKQ-UHFFFAOYSA-N 0.000 claims 1
- 229940028652 abraxane Drugs 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 229960004117 capecitabine Drugs 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 230000005889 cellular cytotoxicity Effects 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
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- 239000002299 complementary DNA Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229960004397 cyclophosphamide Drugs 0.000 claims 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 108700020302 erbB-2 Genes Proteins 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- 201000007281 estrogen-receptor positive breast cancer Diseases 0.000 claims 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
- 229960005420 etoposide Drugs 0.000 claims 1
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims 1
- 235000008191 folinic acid Nutrition 0.000 claims 1
- 239000011672 folinic acid Substances 0.000 claims 1
- -1 forfilinox Chemical compound 0.000 claims 1
- 239000000833 heterodimer Substances 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 201000004653 inflammatory breast carcinoma Diseases 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
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- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 201000010985 invasive ductal carcinoma Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 229960001691 leucovorin Drugs 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 208000026535 luminal A breast carcinoma Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
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- 210000003716 mesoderm Anatomy 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
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- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
- QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical compound C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 claims 1
- 229960005079 pemetrexed Drugs 0.000 claims 1
- 210000003800 pharynx Anatomy 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229960003387 progesterone Drugs 0.000 claims 1
- 239000000186 progesterone Substances 0.000 claims 1
- 108090000468 progesterone receptors Proteins 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000033300 receptor internalization Effects 0.000 claims 1
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- 108020003175 receptors Proteins 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 claims 1
- 208000013718 rectal benign neoplasm Diseases 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 229960003048 vinblastine Drugs 0.000 claims 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims 1
- 229960002066 vinorelbine Drugs 0.000 claims 1
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361910026P | 2013-11-27 | 2013-11-27 | |
| US61/910,026 | 2013-11-27 | ||
| US201462000908P | 2014-05-20 | 2014-05-20 | |
| US62/000,908 | 2014-05-20 | ||
| US201462009125P | 2014-06-06 | 2014-06-06 | |
| US62/009,125 | 2014-06-06 | ||
| PCT/CA2014/051140 WO2015077891A1 (en) | 2013-11-27 | 2014-11-27 | Bispecific antigen-binding constructs targeting her2 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019105971A Division JP6727379B2 (ja) | 2013-11-27 | 2019-06-06 | Ｈｅｒ２を標的とする二重特異性抗原結合性コンストラクト |
| JP2020214847A Division JP2021072788A (ja) | 2013-11-27 | 2020-12-24 | Ｈｅｒ２を標的とする二重特異性抗原結合性コンストラクト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017503480A JP2017503480A (ja) | 2017-02-02 |
| JP2017503480A5 true JP2017503480A5 (enExample) | 2018-01-11 |
| JP6817064B2 JP6817064B2 (ja) | 2021-01-20 |
Family
ID=53198157
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016534706A Active JP6817064B2 (ja) | 2013-11-27 | 2014-11-27 | Ｈｅｒ２を標的とする二重特異性抗原結合性コンストラクト |
| JP2019105971A Active JP6727379B2 (ja) | 2013-11-27 | 2019-06-06 | Ｈｅｒ２を標的とする二重特異性抗原結合性コンストラクト |
| JP2020214847A Pending JP2021072788A (ja) | 2013-11-27 | 2020-12-24 | Ｈｅｒ２を標的とする二重特異性抗原結合性コンストラクト |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019105971A Active JP6727379B2 (ja) | 2013-11-27 | 2019-06-06 | Ｈｅｒ２を標的とする二重特異性抗原結合性コンストラクト |
| JP2020214847A Pending JP2021072788A (ja) | 2013-11-27 | 2020-12-24 | Ｈｅｒ２を標的とする二重特異性抗原結合性コンストラクト |
Country Status (21)
| Country | Link |
|---|---|
| US (6) | US10947319B2 (enExample) |
| EP (2) | EP3074424B1 (enExample) |
| JP (3) | JP6817064B2 (enExample) |
| KR (1) | KR102357906B1 (enExample) |
| CN (1) | CN105980409B (enExample) |
| AU (2) | AU2014357292B2 (enExample) |
| CA (1) | CA2931356A1 (enExample) |
| DK (1) | DK3074424T3 (enExample) |
| ES (1) | ES3030987T3 (enExample) |
| FI (1) | FI3074424T3 (enExample) |
| HR (1) | HRP20250551T1 (enExample) |
| HU (1) | HUE071428T2 (enExample) |
| LT (1) | LT3074424T (enExample) |
| MX (2) | MX376384B (enExample) |
| PL (1) | PL3074424T3 (enExample) |
| PT (1) | PT3074424T (enExample) |
| RS (1) | RS66775B1 (enExample) |
| RU (1) | RU2737882C2 (enExample) |
| SI (1) | SI3074424T1 (enExample) |
| SM (1) | SMT202500219T1 (enExample) |
| WO (1) | WO2015077891A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102052774B1 (ko) | 2011-11-04 | 2019-12-04 | 자임워크스 인코포레이티드 | Ｆｃ 도메인 내의 돌연변이를 갖는 안정한 이종이합체 항체 설계 |
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