JP2017501197A5 - - Google Patents
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- JP2017501197A5 JP2017501197A5 JP2016543735A JP2016543735A JP2017501197A5 JP 2017501197 A5 JP2017501197 A5 JP 2017501197A5 JP 2016543735 A JP2016543735 A JP 2016543735A JP 2016543735 A JP2016543735 A JP 2016543735A JP 2017501197 A5 JP2017501197 A5 JP 2017501197A5
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- JP
- Japan
- Prior art keywords
- compound
- dmf
- group
- formula
- alkylating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361922582P | 2013-12-31 | 2013-12-31 | |
| US201361922572P | 2013-12-31 | 2013-12-31 | |
| US61/922,582 | 2013-12-31 | ||
| US61/922,572 | 2013-12-31 | ||
| PCT/US2014/072569 WO2015103144A1 (en) | 2013-12-31 | 2014-12-29 | 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one and processes for their preparation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019160781A Division JP2019218396A (ja) | 2013-12-31 | 2019-09-04 | 5−フルオロ−4−イミノ−3−(アルキル/置換アルキル)−1−(アリールスルホニル)−3,4−ジヒドロピリミジン−2(1h)−オンおよびそれらの調製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501197A JP2017501197A (ja) | 2017-01-12 |
| JP2017501197A5 true JP2017501197A5 (enExample) | 2018-02-15 |
| JP6585057B2 JP6585057B2 (ja) | 2019-10-02 |
Family
ID=53480979
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016543735A Active JP6585057B2 (ja) | 2013-12-31 | 2014-12-29 | 5−フルオロ−4−イミノ−3−(アルキル/置換アルキル)−1−(アリールスルホニル)−3,4−ジヒドロピリミジン−2(1h)−オンおよびそれらの調製方法 |
| JP2016543746A Active JP6804297B2 (ja) | 2013-12-31 | 2014-12-29 | 5−フルオロ−4−イミノ−3−(アルキル/置換アルキル)−1−(アリールスルホニル)−3,4−ジヒドロピリミジン−2(1h)−オンおよびそれらの調製方法 |
| JP2019160781A Withdrawn JP2019218396A (ja) | 2013-12-31 | 2019-09-04 | 5−フルオロ−4−イミノ−3−(アルキル/置換アルキル)−1−(アリールスルホニル)−3,4−ジヒドロピリミジン−2(1h)−オンおよびそれらの調製方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016543746A Active JP6804297B2 (ja) | 2013-12-31 | 2014-12-29 | 5−フルオロ−4−イミノ−3−(アルキル/置換アルキル)−1−(アリールスルホニル)−3,4−ジヒドロピリミジン−2(1h)−オンおよびそれらの調製方法 |
| JP2019160781A Withdrawn JP2019218396A (ja) | 2013-12-31 | 2019-09-04 | 5−フルオロ−4−イミノ−3−(アルキル/置換アルキル)−1−(アリールスルホニル)−3,4−ジヒドロピリミジン−2(1h)−オンおよびそれらの調製方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (8) | US20150183750A1 (enExample) |
| EP (4) | EP3094632A4 (enExample) |
| JP (3) | JP6585057B2 (enExample) |
| CN (4) | CN111362881A (enExample) |
| AP (1) | AP2016009342A0 (enExample) |
| AU (2) | AU2014373959B2 (enExample) |
| BR (2) | BR102014033010B1 (enExample) |
| CA (2) | CA2935594C (enExample) |
| CL (1) | CL2016001677A1 (enExample) |
| CR (2) | CR20210172A (enExample) |
| DO (1) | DOP2016000163A (enExample) |
| EA (2) | EA201691353A1 (enExample) |
| EC (1) | ECSP16064249A (enExample) |
| IL (3) | IL246512B (enExample) |
| MX (2) | MX375727B (enExample) |
| NI (1) | NI201600094A (enExample) |
| NZ (2) | NZ722439A (enExample) |
| PE (1) | PE20161174A1 (enExample) |
| PH (1) | PH12016501284A1 (enExample) |
| SG (2) | SG11201605372QA (enExample) |
| TW (2) | TWI667229B (enExample) |
| UA (2) | UA129860C2 (enExample) |
| UY (2) | UY35943A (enExample) |
| WO (2) | WO2015103144A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104884062B (zh) | 2012-12-28 | 2018-11-06 | 阿达玛马克西姆股份有限公司 | N-(取代的)-5-氟-4-亚氨基-3-甲基-2-氧代-3,4-二氢嘧啶-1(2h)-甲酰胺衍生物 |
| CN104902757B (zh) | 2012-12-28 | 2019-01-08 | 阿达玛马克西姆股份有限公司 | N-(取代的)-5-氟-4-亚氨基-3-甲基-2-氧代-3,4-二氢嘧啶-1(2h)-羧酸酯衍生物 |
| JP2016503816A (ja) | 2012-12-31 | 2016-02-08 | ダウ アグロサイエンシィズ エルエルシー | 殺真菌剤としての3−アルキル−5−フルオロ−4置換イミノ−3,4−ジヒドロピリミジン−2(1h)−オン誘導体 |
| CR20160345A (es) | 2013-12-31 | 2017-02-21 | Adama Makhteshim Ltd | Mezclas fungicidas sinérgicas y composiciones que comprenden 5-fluoro-4-imino-3-metil-1-tosil-3,4-dihidropirimidin-2(1h)-ona e inhibidor(es) de la biosíntesis de esteroles para el control fúngico |
| JP6585057B2 (ja) | 2013-12-31 | 2019-10-02 | アダマ・マクテシム・リミテッド | 5−フルオロ−4−イミノ−3−(アルキル/置換アルキル)−1−(アリールスルホニル)−3,4−ジヒドロピリミジン−2(1h)−オンおよびそれらの調製方法 |
| UY36964A (es) | 2015-10-27 | 2017-05-31 | Bayer Cropscience Ag | Combinaciones de principios activos que comprenden un derivado de (tio) carboxamida y un compuesto funguicida |
| JP6922271B2 (ja) * | 2016-03-11 | 2021-08-18 | 住友化学株式会社 | 植物病害防除組成物及び植物病害防除方法 |
| AU2018320492C1 (en) * | 2017-07-17 | 2023-07-13 | Adama Makhteshim Ltd. | Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2-one |
| WO2020095181A1 (en) * | 2018-11-05 | 2020-05-14 | Adama Makhteshim Ltd. | Mixtures and compositions comprising 5-fluoro-4-imino-3- methyl-1-tosyl-3,4-dihydropyrimidin-2-one, and methods of use thereof |
| CN114901073A (zh) | 2019-07-22 | 2022-08-12 | 阿达马蒂斯有限公司 | 杀真菌组合、混合物和组合物及其用途 |
| UY38890A (es) | 2019-09-23 | 2021-04-30 | Adama Makhteshim Ltd | Procedimiento para preparar 5-(fluoro-4-imino-3-metil)-1-tosil-3,4-dihidropirimidin-(1h)-ona y derivados del compuesto |
| IL296178A (en) * | 2020-03-09 | 2022-11-01 | Adama Makhteshim Ltd | Process for preparing 5-fluoro-4-imino-3-methyl-1-(toluene-4-sulfonyl)-4,3-dihydro-1h-pyrimidin-2-one |
| UY39197A (es) * | 2020-05-04 | 2021-11-30 | Adama Makhteshim Ltd | Mezclas y composiciones que comprenden 5-fluoro-4-imino-3- metil-1-tosil-3,4-dihidropirimidin-2-ona, y métodos de uso de las mismas |
| CR20230077A (es) | 2020-07-08 | 2023-07-26 | Adama Makhteshim Ltd | Mezclas fungicidas |
| EP4284173A1 (en) | 2021-01-27 | 2023-12-06 | Adama Makhteshim Ltd. | 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1 h)-one for controlling plant diseases |
| MX2023012897A (es) | 2021-05-04 | 2023-12-06 | Adama Makhteshim Ltd | Formas cristalinas de 5-fluoro-4-imino-3-metil-1-tosil-3,4- dihidropirimidin-2-ona, y mezclas, composiciones y metodos de uso de las mismas. |
| WO2023042126A1 (en) | 2021-09-15 | 2023-03-23 | Adama Makhteshim Ltd. | Process for preparing 5-fluoro-4-imino-3-methyl-1-(toluene-4-sulfonyl)-3,4-dihydro-1h-pyrimidin-2-one |
| UY40172A (es) | 2022-03-03 | 2023-10-13 | Adama Makhteshim Ltd | Combinaciones, mezclas y composiciones fungicidas y usos de las mismas |
| EP4531570A1 (en) | 2022-05-26 | 2025-04-09 | Adama Makhteshim Ltd. | Fungicidal combinations, mixtures and compositions and uses thereof |
| AU2023318916A1 (en) | 2022-08-03 | 2025-02-20 | Adama Makhteshim Ltd. | 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1h)-one for fungicide-resistant fungus |
| EP4676225A1 (en) | 2023-03-09 | 2026-01-14 | Adama Makhteshim Ltd. | Fungicidal combinations, mixtures and compositions and uses thereof |
| CN120882311A (zh) | 2023-03-14 | 2025-10-31 | 安道麦马克西姆有限公司 | 含有5-(氟-4-亚氨基-3-甲基)-1-甲苯磺酰基-3,4二氢嘧啶-(1h)-酮及其衍生物以及uv吸收剂的液体组合物 |
| EP4683910A1 (en) | 2023-03-23 | 2026-01-28 | Adama Makhteshim Ltd. | Process for preparing 5-fluoro-4-imino-3-methyl-1-(toluene-4-sulfonyl)-3,4-dihydro-1h-pyrimidin-2-one |
| WO2025046581A1 (en) | 2023-08-31 | 2025-03-06 | Adama Makhteshim Ltd. | Fungicidal combinations, mixtures and compositions and uses thereo |
| IL308593A (en) | 2023-11-15 | 2025-06-01 | Adama Makhteshim Ltd | Reducing environmental impact of fungicidal enhancement |
| WO2025114931A1 (en) | 2023-11-28 | 2025-06-05 | Adama Makhteshim Ltd. | Fungicidal combinations, mixtures and compositions and uses thereof |
| WO2025203024A1 (en) | 2024-03-26 | 2025-10-02 | Adama Makhteshim Ltd. | Process for preparing 5-fluoro-4-imino-3-methyl-1-(toluene-4-sulfonyl)-3,4-dihydro-1h-pyrimidin-2-one |
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| US3309359A (en) | 1965-10-22 | 1967-03-14 | Hoffmann La Roche | N-mono-acyl-5-fluorocytosine derivatives and process |
| US3368938A (en) | 1966-01-13 | 1968-02-13 | Hoffmann La Roche | Controlling fungi with 5-fluorocytosine |
| US3635977A (en) | 1969-11-03 | 1972-01-18 | American Cyanamid Co | Certain 6-trifluoromethylcytosines and thiocytosines their synthesis and their use in the synthesis of uracisls and thiouracil |
| US3868373A (en) | 1970-01-27 | 1975-02-25 | Hoffmann La Roche | 4-Amino-5-fluoro-2-tri(lower alkyl) silyloxypyrimidines |
| US4009272A (en) | 1971-10-23 | 1977-02-22 | Bayer Aktiengesellschaft | Penicillins |
| CH579057A5 (enExample) | 1973-09-07 | 1976-08-31 | Hoffmann La Roche | |
| JPS601793B2 (ja) | 1979-12-06 | 1985-01-17 | 松下電器産業株式会社 | カラ−テレビジョン受像機の画質改善装置 |
| FR2530636A1 (fr) | 1982-07-23 | 1984-01-27 | Rhone Poulenc Agrochimie | Nouveaux derives de la tetrahydro-2,3,6,7 5h-thiazolo (3,2-a) pyrimidine, leur preparation et leur utilisation comme herbicides |
| GR80171B (en) | 1983-08-29 | 1985-01-02 | Ciba Geigy Ag | N-(2-nitrophenyl)-4-aminopyrimidine derivatives process for the preparation thereof and use |
| US4845081A (en) | 1984-10-18 | 1989-07-04 | University Of Florida | Aminomethyl derivatives of biologically active substances, and enhanced delivery thereof across topical membranes |
| EP0230922A2 (de) | 1986-01-21 | 1987-08-05 | Boehringer Ingelheim Kg | Verwendung von Peptiden zur Herstellung von Mitteln zur Behandlung von Coronarerkrankungen oder organischem Hirnsyndrom |
| ATE109776T1 (de) | 1988-03-09 | 1994-08-15 | Ciba Geigy Ag | Mittel zum schutz von pflanzen gegen krankheiten. |
| DE3821711A1 (de) | 1988-06-28 | 1990-02-08 | Bayer Ag | Thiazolopyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel |
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| GT199900185A (es) | 1998-11-06 | 2001-04-18 | Novedosa pirimidin-4-enamina como fungicida. | |
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| KR20080070676A (ko) | 2005-11-22 | 2008-07-30 | 이시하라 산교 가부시끼가이샤 | 농원예용 살균제 조성물 및 식물 병해의 방제 방법 |
| US20080004253A1 (en) | 2006-06-30 | 2008-01-03 | Bryan James Branstetter | Thiazolopyrimidine modulators of TRPV1 |
| US20100029483A1 (en) | 2006-10-16 | 2010-02-04 | Rhodia Inc. | Agricultural adjuvant compositions, pesticide compositions, and methods for using such compositions |
| KR101119809B1 (ko) | 2006-10-20 | 2012-03-21 | 수미도모 메탈 인더스트리즈, 리미티드 | 화학 플랜트용 니켈재 |
| WO2008083465A1 (en) | 2007-01-08 | 2008-07-17 | University Health Network | Pyrimidine derivatives as anticancer agents |
| EP2252594B1 (en) | 2008-01-22 | 2015-08-19 | Dow AgroSciences LLC | 4-amino-5-fluoro-pyrimidine derivatives as fungicides |
| EP2317851B1 (en) | 2008-08-01 | 2014-01-15 | Dow AgroSciences LLC | Use of 5-fluorocytosine as a fungicide |
| WO2010033198A2 (en) | 2008-09-17 | 2010-03-25 | Sri International | Analogs of indole-3-carbinol and their use as agents against infection |
| USRE46144E1 (en) | 2009-01-23 | 2016-09-13 | Purdue Pharmaceutical Products L.P. | Hydroxamic acid derivatives |
| PE20120691A1 (es) | 2009-08-07 | 2012-06-08 | Dow Agrosciences Llc | Derivados de n1-sulfonil-5-fluoropirimidinona |
| UA112284C2 (uk) * | 2009-08-07 | 2016-08-25 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні 5-фторпіримідинону |
| UA106889C2 (uk) | 2009-08-07 | 2014-10-27 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні n1-ацил-5-фторпіримідинону |
| UA107671C2 (en) | 2009-08-07 | 2015-02-10 | Dow Agrosciences Llc | N1-substityted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives |
| UA106086C2 (uk) | 2009-08-07 | 2014-07-25 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | 5-фтор-2-оксопіримідин-1(2h)-карбоксилатні похідні |
| US20110082162A1 (en) | 2009-10-07 | 2011-04-07 | Dow Agrosciences Llc | Synergistic fungicidal composition containing 5-fluorocytosine for fungal control in cereals |
| RS55239B1 (sr) * | 2010-04-26 | 2017-02-28 | Adama Makhteshim Ltd | N3-supstituisani derivati n1-sulfonil-5-fluorpirimidinona |
| HUE035248T2 (en) * | 2011-08-17 | 2018-05-02 | Adama Makhteshim Ltd | 1-Substituted-5-fluoro-3,6-dihydro-6-imino-2 (1H) -pyrimidinone derivatives as fungicidal compositions for use in plant protection |
| WO2014073114A1 (en) | 2012-11-07 | 2014-05-15 | Toyota Jidosha Kabushiki Kaisha | Method for producing a catalyst for fuel cells |
| CN104994859B (zh) * | 2012-12-28 | 2018-10-26 | 阿达玛马克西姆股份有限公司 | 1-(取代的苯甲酰基)-5-氟-4-亚氨基-3-甲基-3,4-二氢嘧啶-2(1h)-酮衍生物 |
| CN104884062B (zh) | 2012-12-28 | 2018-11-06 | 阿达玛马克西姆股份有限公司 | N-(取代的)-5-氟-4-亚氨基-3-甲基-2-氧代-3,4-二氢嘧啶-1(2h)-甲酰胺衍生物 |
| CN104902757B (zh) | 2012-12-28 | 2019-01-08 | 阿达玛马克西姆股份有限公司 | N-(取代的)-5-氟-4-亚氨基-3-甲基-2-氧代-3,4-二氢嘧啶-1(2h)-羧酸酯衍生物 |
| JP2016503816A (ja) | 2012-12-31 | 2016-02-08 | ダウ アグロサイエンシィズ エルエルシー | 殺真菌剤としての3−アルキル−5−フルオロ−4置換イミノ−3,4−ジヒドロピリミジン−2(1h)−オン誘導体 |
| CR20160345A (es) | 2013-12-31 | 2017-02-21 | Adama Makhteshim Ltd | Mezclas fungicidas sinérgicas y composiciones que comprenden 5-fluoro-4-imino-3-metil-1-tosil-3,4-dihidropirimidin-2(1h)-ona e inhibidor(es) de la biosíntesis de esteroles para el control fúngico |
| JP6585057B2 (ja) | 2013-12-31 | 2019-10-02 | アダマ・マクテシム・リミテッド | 5−フルオロ−4−イミノ−3−(アルキル/置換アルキル)−1−(アリールスルホニル)−3,4−ジヒドロピリミジン−2(1h)−オンおよびそれらの調製方法 |
| MA41272A (fr) | 2014-12-23 | 2017-10-31 | Adama Makhteshim Ltd | 5-fluoro-4-imino-3-(alkyle/alkyle substitué)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one en tant que traitement des semences |
-
2014
- 2014-12-29 JP JP2016543735A patent/JP6585057B2/ja active Active
- 2014-12-29 EP EP14875976.4A patent/EP3094632A4/en not_active Ceased
- 2014-12-29 CN CN201911357017.1A patent/CN111362881A/zh active Pending
- 2014-12-29 JP JP2016543746A patent/JP6804297B2/ja active Active
- 2014-12-29 US US14/584,368 patent/US20150183750A1/en not_active Abandoned
- 2014-12-29 US US14/584,347 patent/US20150183749A1/en not_active Abandoned
- 2014-12-29 EP EP14877285.8A patent/EP3097096A4/en not_active Ceased
- 2014-12-29 EA EA201691353A patent/EA201691353A1/ru unknown
- 2014-12-29 EA EA201691351A patent/EA036389B1/ru not_active IP Right Cessation
- 2014-12-29 CN CN201480076583.4A patent/CN106061972B/zh active Active
- 2014-12-29 SG SG11201605372QA patent/SG11201605372QA/en unknown
- 2014-12-29 CR CR20210172A patent/CR20210172A/es unknown
- 2014-12-29 PE PE2016000974A patent/PE20161174A1/es unknown
- 2014-12-29 SG SG11201605377VA patent/SG11201605377VA/en unknown
- 2014-12-29 AU AU2014373959A patent/AU2014373959B2/en active Active
- 2014-12-29 MX MX2016008758A patent/MX375727B/es active IP Right Grant
- 2014-12-29 WO PCT/US2014/072569 patent/WO2015103144A1/en not_active Ceased
- 2014-12-29 CN CN201911242098.0A patent/CN111217759A/zh active Pending
- 2014-12-29 AU AU2014373961A patent/AU2014373961B2/en active Active
- 2014-12-29 CN CN201480076563.7A patent/CN106068268A/zh active Pending
- 2014-12-29 EP EP21151090.4A patent/EP3862346A1/en active Pending
- 2014-12-29 MX MX2016008759A patent/MX392211B/es unknown
- 2014-12-29 CA CA2935594A patent/CA2935594C/en active Active
- 2014-12-29 UA UAA201909738A patent/UA129860C2/uk unknown
- 2014-12-29 NZ NZ722439A patent/NZ722439A/en unknown
- 2014-12-29 EP EP21151157.1A patent/EP3862347A1/en not_active Withdrawn
- 2014-12-29 AP AP2016009342A patent/AP2016009342A0/en unknown
- 2014-12-29 CR CR20160343A patent/CR20160343A/es unknown
- 2014-12-29 CA CA2935601A patent/CA2935601C/en active Active
- 2014-12-29 UA UAA201608339A patent/UA122200C2/uk unknown
- 2014-12-29 WO PCT/US2014/072566 patent/WO2015103142A1/en not_active Ceased
- 2014-12-29 NZ NZ722438A patent/NZ722438A/en unknown
- 2014-12-30 UY UY0001035943A patent/UY35943A/es not_active Application Discontinuation
- 2014-12-30 BR BR102014033010-0A patent/BR102014033010B1/pt active IP Right Grant
- 2014-12-30 BR BR102014033037-2A patent/BR102014033037B1/pt active IP Right Grant
- 2014-12-30 UY UY0001035942A patent/UY35942A/es not_active Application Discontinuation
- 2014-12-31 TW TW103146560A patent/TWI667229B/zh active
- 2014-12-31 TW TW103146555A patent/TWI722979B/zh active
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2016
- 2016-06-03 US US15/173,493 patent/US9850215B2/en active Active
- 2016-06-03 US US15/173,529 patent/US9840476B2/en active Active
- 2016-06-28 IL IL246512A patent/IL246512B/en active IP Right Grant
- 2016-06-28 IL IL24651116A patent/IL246511B/en active IP Right Grant
- 2016-06-29 DO DO2016000163A patent/DOP2016000163A/es unknown
- 2016-06-29 CL CL2016001677A patent/CL2016001677A1/es unknown
- 2016-06-29 NI NI201600094A patent/NI201600094A/es unknown
- 2016-06-29 PH PH12016501284A patent/PH12016501284A1/en unknown
- 2016-07-29 EC ECIEPI201664249A patent/ECSP16064249A/es unknown
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2017
- 2017-11-15 US US15/813,562 patent/US20180072686A1/en not_active Abandoned
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2019
- 2019-06-21 US US16/448,633 patent/US20190308941A1/en not_active Abandoned
- 2019-09-04 JP JP2019160781A patent/JP2019218396A/ja not_active Withdrawn
- 2019-09-26 IL IL269694A patent/IL269694B/en unknown
- 2019-09-27 US US16/585,239 patent/US20200024238A1/en not_active Abandoned
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2020
- 2020-01-13 US US16/741,026 patent/US10919864B2/en active Active