JP2014520901A5

JP2014520901A5 -

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Publication number: JP2014520901A5
Authority: JP; Japan
Prior art keywords: formula; compound; group; halo; reaction
Prior art date: 2012-07-20
Legal status : Granted

Application number

JP2014522149A

Other languages

English (en)

Japanese (ja)

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JP2014520901A (ja

JP5996647B2 (ja

Filing date

2012-07-20

Publication date

2014-10-16

2012-07-20 Application filed filed Critical

2012-07-20 Priority claimed from PCT/GB2012/051746 external-priority patent/WO2013014428A1/en

2014-08-25 Publication of JP2014520901A publication Critical patent/JP2014520901A/ja

2014-10-16 Publication of JP2014520901A5 publication Critical patent/JP2014520901A5/ja

2016-09-21 Application granted granted Critical

2016-09-21 Publication of JP5996647B2 publication Critical patent/JP5996647B2/ja

Status Active legal-status Critical Current

2032-07-20 Anticipated expiration legal-status Critical

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238000000034 method Methods 0.000 claims 16
150000001875 compounds Chemical class 0.000 claims 14
238000006243 chemical reaction Methods 0.000 claims 5
125000005843 halogen group Chemical group 0.000 claims 5
238000002360 preparation method Methods 0.000 claims 4
PNKUSGQVOMIXLU-UHFFFAOYSA-N Formamidine Chemical compound NC=N PNKUSGQVOMIXLU-UHFFFAOYSA-N 0.000 claims 3
125000003545 alkoxy group Chemical group 0.000 claims 3
125000000217 alkyl group Chemical group 0.000 claims 3
125000001246 bromo group Chemical group Br* 0.000 claims 3
125000001153 fluoro group Chemical group F* 0.000 claims 3
239000000203 mixture Substances 0.000 claims 3
125000001424 substituent group Chemical group 0.000 claims 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 2
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 2
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
XPOLVIIHTDKJRY-UHFFFAOYSA-N acetic acid;methanimidamide Chemical compound NC=N.CC(O)=O XPOLVIIHTDKJRY-UHFFFAOYSA-N 0.000 claims 2
125000002947 alkylene group Chemical group 0.000 claims 2
230000031709 bromination Effects 0.000 claims 2
238000005893 bromination reaction Methods 0.000 claims 2
238000009472 formulation Methods 0.000 claims 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 2
150000003839 salts Chemical class 0.000 claims 2
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
125000006582 (C5-C6) heterocycloalkyl group Chemical group 0.000 claims 1
NYYSPVRERVXMLJ-UHFFFAOYSA-N 4,4-difluorocyclohexan-1-one Chemical compound FC1(F)CCC(=O)CC1 NYYSPVRERVXMLJ-UHFFFAOYSA-N 0.000 claims 1
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims 1
AMATXUCYHHHHHB-UHFFFAOYSA-N 5,5-dibromo-1,3-diazinane-2,4,6-trione Chemical compound BrC1(Br)C(=O)NC(=O)NC1=O AMATXUCYHHHHHB-UHFFFAOYSA-N 0.000 claims 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
235000019270 ammonium chloride Nutrition 0.000 claims 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
229910052794 bromium Inorganic materials 0.000 claims 1
MLUCVPSAIODCQM-NSCUHMNNSA-N crotonaldehyde Chemical compound C\C=C\C=O MLUCVPSAIODCQM-NSCUHMNNSA-N 0.000 claims 1
MLUCVPSAIODCQM-UHFFFAOYSA-N crotonaldehyde Natural products CC=CC=O MLUCVPSAIODCQM-UHFFFAOYSA-N 0.000 claims 1
235000019253 formic acid Nutrition 0.000 claims 1
239000012634 fragment Substances 0.000 claims 1
125000005842 heteroatom Chemical group 0.000 claims 1
239000004615 ingredient Substances 0.000 claims 1
150000002500 ions Chemical class 0.000 claims 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
229910052757 nitrogen Inorganic materials 0.000 claims 1
125000004433 nitrogen atom Chemical group N* 0.000 claims 1
125000005254 oxyacyl group Chemical group 0.000 claims 1
125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 1
CKNOCKWLNHPVRL-UHFFFAOYSA-N CC(C(C=O)Br)c1c(C)c(C)ccc1 Chemical compound CC(C(C=O)Br)c1c(C)c(C)ccc1 CKNOCKWLNHPVRL-UHFFFAOYSA-N 0.000 description 1
0 Cc1c(C)c(B(O*)O*)ccc1 Chemical compound Cc1c(C)c(B(O*)O*)ccc1 0.000 description 1

JP2014522149A 2011-07-22 2012-07-20 ４−置換イミダゾールの新規な調製プロセス Active JP5996647B2 (ja)