JP2018502137A5 - - Google Patents
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- Publication number
- JP2018502137A5 JP2018502137A5 JP2017537924A JP2017537924A JP2018502137A5 JP 2018502137 A5 JP2018502137 A5 JP 2018502137A5 JP 2017537924 A JP2017537924 A JP 2017537924A JP 2017537924 A JP2017537924 A JP 2017537924A JP 2018502137 A5 JP2018502137 A5 JP 2018502137A5
- Authority
- JP
- Japan
- Prior art keywords
- halo
- pharmaceutically acceptable
- independently selected
- group
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 125000001475 halogen functional group Chemical group 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 208000007536 Thrombosis Diseases 0.000 claims 5
- 230000015572 biosynthetic process Effects 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- -1 hydroxy, methoxy Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 1
- 206010014498 Embolic stroke Diseases 0.000 claims 1
- 206010014522 Embolism venous Diseases 0.000 claims 1
- 208000010378 Pulmonary Embolism Diseases 0.000 claims 1
- 108090000190 Thrombin Proteins 0.000 claims 1
- 206010047249 Venous thrombosis Diseases 0.000 claims 1
- 230000035602 clotting Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 229960004072 thrombin Drugs 0.000 claims 1
- 208000004043 venous thromboembolism Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562105385P | 2015-01-20 | 2015-01-20 | |
| US62/105,385 | 2015-01-20 | ||
| PCT/US2016/013507 WO2016118403A1 (en) | 2015-01-20 | 2016-01-15 | Factor xia inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018502137A JP2018502137A (ja) | 2018-01-25 |
| JP2018502137A5 true JP2018502137A5 (enExample) | 2019-02-21 |
Family
ID=56417605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017537924A Ceased JP2018502137A (ja) | 2015-01-20 | 2016-01-15 | 第ＸＩａ因子阻害剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10123995B2 (enExample) |
| EP (1) | EP3247354B1 (enExample) |
| JP (1) | JP2018502137A (enExample) |
| KR (1) | KR20170103962A (enExample) |
| CN (1) | CN107106548A (enExample) |
| AU (1) | AU2016209623B2 (enExample) |
| BR (1) | BR112017015431A2 (enExample) |
| CA (1) | CA2973202A1 (enExample) |
| MX (1) | MX2017009445A (enExample) |
| RU (1) | RU2712268C2 (enExample) |
| WO (1) | WO2016118403A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9975874B2 (en) | 2014-07-28 | 2018-05-22 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
| US10081617B2 (en) | 2015-04-16 | 2018-09-25 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
| EP3383847B1 (en) * | 2015-12-02 | 2022-08-24 | Merck Sharp & Dohme LLC | FACTOR XIa INHIBITORS |
| US10143681B2 (en) | 2016-08-22 | 2018-12-04 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
| EP3351122B1 (en) * | 2016-10-12 | 2020-06-17 | Changzhou Patent Electronic Technology Co., Ltd | Mouth piece of electronic cigarette, e-liquid cartridge, and electronic cigarette |
| WO2021121396A1 (zh) * | 2019-12-20 | 2021-06-24 | 成都康弘药业集团股份有限公司 | 作为血浆激肽释放酶抑制剂的三环类化合物及其用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8163749B2 (en) * | 2005-12-14 | 2012-04-24 | Bristol-Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
| WO2007109459A2 (en) * | 2006-03-21 | 2007-09-27 | Janssen Pharmaceutica, Nv | Pyridines and pyridine n-oxides as modulators of thrombin |
| MX2009012847A (es) * | 2007-06-13 | 2009-12-08 | Bristol Myers Squibb Co | Analogos dipeptidicos como inhibidores de factores de coagulacion. |
| PE20091825A1 (es) * | 2008-04-04 | 2009-12-04 | Merck & Co Inc | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
| KR101843542B1 (ko) * | 2010-02-11 | 2018-03-30 | 브리스톨-마이어스 스큅 컴퍼니 | 인자 ＸＩａ 억제제로서의 마크로사이클 |
| US8592426B2 (en) * | 2011-01-24 | 2013-11-26 | Hoffmann—La Roche Inc. | Aryl-benzocycloalkyl amide derivatives |
| EP2744499B1 (en) | 2011-08-19 | 2016-09-28 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| RU2015111206A (ru) | 2012-08-30 | 2016-10-20 | Ниппон Синяку Ко., Лтд. | Пиридиновое производное и лекарственное средство |
| WO2014081618A1 (en) * | 2012-11-20 | 2014-05-30 | Merck Sharp & Dohme Corp. | Thrombin inhibitors |
| CN106413710A (zh) | 2014-05-28 | 2017-02-15 | 默沙东公司 | 因子XIa抑制剂 |
| WO2016018701A1 (en) | 2014-07-28 | 2016-02-04 | Merck Sharp & Dohme Corp. | FACTOR XIa INHIBITORS |
| EP3180317B1 (en) | 2014-07-28 | 2021-04-14 | Merck Sharp & Dohme Corp. | FACTOR XIa INHIBITORS |
| US9975874B2 (en) | 2014-07-28 | 2018-05-22 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
-
2016
- 2016-01-15 WO PCT/US2016/013507 patent/WO2016118403A1/en not_active Ceased
- 2016-01-15 MX MX2017009445A patent/MX2017009445A/es unknown
- 2016-01-15 BR BR112017015431A patent/BR112017015431A2/pt not_active Application Discontinuation
- 2016-01-15 CN CN201680006558.8A patent/CN107106548A/zh active Pending
- 2016-01-15 JP JP2017537924A patent/JP2018502137A/ja not_active Ceased
- 2016-01-15 EP EP16740526.5A patent/EP3247354B1/en active Active
- 2016-01-15 RU RU2017129275A patent/RU2712268C2/ru not_active IP Right Cessation
- 2016-01-15 CA CA2973202A patent/CA2973202A1/en not_active Abandoned
- 2016-01-15 KR KR1020177022768A patent/KR20170103962A/ko not_active Withdrawn
- 2016-01-15 US US15/542,948 patent/US10123995B2/en active Active
- 2016-01-15 AU AU2016209623A patent/AU2016209623B2/en not_active Ceased
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