MX2017009445A - Inhibidores del factor xia. - Google Patents
Inhibidores del factor xia.Info
- Publication number
- MX2017009445A MX2017009445A MX2017009445A MX2017009445A MX2017009445A MX 2017009445 A MX2017009445 A MX 2017009445A MX 2017009445 A MX2017009445 A MX 2017009445A MX 2017009445 A MX2017009445 A MX 2017009445A MX 2017009445 A MX2017009445 A MX 2017009445A
- Authority
- MX
- Mexico
- Prior art keywords
- factor xia
- compounds
- xia inhibitors
- inhibitors
- hypercoagulability
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562105385P | 2015-01-20 | 2015-01-20 | |
| PCT/US2016/013507 WO2016118403A1 (en) | 2015-01-20 | 2016-01-15 | Factor xia inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017009445A true MX2017009445A (es) | 2017-11-08 |
Family
ID=56417605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017009445A MX2017009445A (es) | 2015-01-20 | 2016-01-15 | Inhibidores del factor xia. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10123995B2 (enExample) |
| EP (1) | EP3247354B1 (enExample) |
| JP (1) | JP2018502137A (enExample) |
| KR (1) | KR20170103962A (enExample) |
| CN (1) | CN107106548A (enExample) |
| AU (1) | AU2016209623B2 (enExample) |
| BR (1) | BR112017015431A2 (enExample) |
| CA (1) | CA2973202A1 (enExample) |
| MX (1) | MX2017009445A (enExample) |
| RU (1) | RU2712268C2 (enExample) |
| WO (1) | WO2016118403A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9975874B2 (en) | 2014-07-28 | 2018-05-22 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
| US10081617B2 (en) | 2015-04-16 | 2018-09-25 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
| US10472344B2 (en) | 2015-12-02 | 2019-11-12 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
| TW201808908A (zh) | 2016-08-22 | 2018-03-16 | 美商默沙東藥廠 | 因子XIa抑制劑 |
| WO2018068577A1 (zh) * | 2016-10-12 | 2018-04-19 | 常州市派腾电子技术服务有限公司 | 一种电子烟烟嘴、烟弹及电子烟 |
| WO2021121396A1 (zh) * | 2019-12-20 | 2021-06-24 | 成都康弘药业集团股份有限公司 | 作为血浆激肽释放酶抑制剂的三环类化合物及其用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007070818A1 (en) * | 2005-12-14 | 2007-06-21 | Bristol-Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
| US7829584B2 (en) | 2006-03-21 | 2010-11-09 | Janssen Pharmaceutica Nv | Pyridines and pyridine N-oxides as modulators of thrombin |
| CN101784516B (zh) * | 2007-06-13 | 2014-07-02 | 百时美施贵宝公司 | 作为凝血因子抑制剂的二肽类似物 |
| PE20091825A1 (es) * | 2008-04-04 | 2009-12-04 | Merck & Co Inc | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
| PH12012501589A1 (en) * | 2010-02-11 | 2012-10-22 | Bristol Myers Squibb Co | Macrocycles as factor xia inhibitors |
| US8592426B2 (en) * | 2011-01-24 | 2013-11-26 | Hoffmann—La Roche Inc. | Aryl-benzocycloalkyl amide derivatives |
| US9062070B2 (en) | 2011-08-19 | 2015-06-23 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| CA2881638A1 (en) | 2012-08-30 | 2014-03-06 | Nippon Shinyaku Co., Ltd. | Pyridine derivative and medicine |
| EP2922535B1 (en) * | 2012-11-20 | 2021-11-10 | Merck Sharp & Dohme Corp. | Thrombin inhibitors |
| RU2016150410A (ru) * | 2014-05-28 | 2018-06-28 | Мерк Шарп И Доум Корп. | Ингибиторы фактора xia |
| US10011585B2 (en) | 2014-07-28 | 2018-07-03 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
| US9975874B2 (en) | 2014-07-28 | 2018-05-22 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
| EP3180317B1 (en) | 2014-07-28 | 2021-04-14 | Merck Sharp & Dohme Corp. | FACTOR XIa INHIBITORS |
-
2016
- 2016-01-15 BR BR112017015431A patent/BR112017015431A2/pt not_active Application Discontinuation
- 2016-01-15 WO PCT/US2016/013507 patent/WO2016118403A1/en not_active Ceased
- 2016-01-15 JP JP2017537924A patent/JP2018502137A/ja not_active Ceased
- 2016-01-15 EP EP16740526.5A patent/EP3247354B1/en active Active
- 2016-01-15 MX MX2017009445A patent/MX2017009445A/es unknown
- 2016-01-15 AU AU2016209623A patent/AU2016209623B2/en not_active Ceased
- 2016-01-15 CN CN201680006558.8A patent/CN107106548A/zh active Pending
- 2016-01-15 US US15/542,948 patent/US10123995B2/en active Active
- 2016-01-15 KR KR1020177022768A patent/KR20170103962A/ko not_active Withdrawn
- 2016-01-15 RU RU2017129275A patent/RU2712268C2/ru not_active IP Right Cessation
- 2016-01-15 CA CA2973202A patent/CA2973202A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20180000795A1 (en) | 2018-01-04 |
| EP3247354A4 (en) | 2018-06-27 |
| RU2017129275A (ru) | 2019-02-21 |
| CN107106548A (zh) | 2017-08-29 |
| RU2017129275A3 (enExample) | 2019-07-26 |
| AU2016209623A1 (en) | 2017-07-13 |
| AU2016209623B2 (en) | 2019-11-14 |
| CA2973202A1 (en) | 2016-07-28 |
| JP2018502137A (ja) | 2018-01-25 |
| KR20170103962A (ko) | 2017-09-13 |
| BR112017015431A2 (pt) | 2018-01-16 |
| US10123995B2 (en) | 2018-11-13 |
| RU2712268C2 (ru) | 2020-01-28 |
| WO2016118403A1 (en) | 2016-07-28 |
| EP3247354B1 (en) | 2019-08-07 |
| EP3247354A1 (en) | 2017-11-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2016015484A (es) | Inhibidores del factor xia. | |
| MX387515B (es) | Inhibidores de factor xia. | |
| PH12020500195A1 (en) | Pyrimidinones as factor xia inhibitors | |
| PH12018500408A1 (en) | Bicyclic compounds as atx inhibitors | |
| PH12018500457A1 (en) | New phenoxymethyl derivatives | |
| MX2018001890A (es) | Compuestos biciclicos como inhibidores de autotaxina (atx). | |
| PH12018500409A1 (en) | New bicyclic compounds as dual atx/ca inhibitors | |
| MX2020005213A (es) | Inhibidores de proteina cinasa 2 activada por proteina cinasa activada por mitogeno (mk2) y sus usos. | |
| NZ742742A (en) | Compositions and methods for inhibiting arginase activity | |
| EP4327809A3 (en) | Tyk2 inhibitors and uses thereof | |
| PH12017501523A1 (en) | Selective bace1 inhibitors | |
| MX2017009445A (es) | Inhibidores del factor xia. | |
| MY189557A (en) | Pyridone compound as c-met inhibitor | |
| MA40457A (fr) | Combinaison de médicaments pour traiter le myélome multiple | |
| PH12017501879A1 (en) | Methods for treating cancer | |
| TW201613892A (en) | Forms and compositions of an ERK inhibitor | |
| PH12017501880A1 (en) | Methods for treating cancer | |
| MX2016015298A (es) | Inhibidores de nampt y metodos. | |
| EA201790851A1 (ru) | Способы предотвращения, уменьшения и лечения макулодистрофии | |
| MX2023008753A (es) | Inhibidores del factor xia. | |
| PH12018500406A1 (en) | Bicyclic compounds as atx inhibitors | |
| PH12018500407A1 (en) | New bicyclic compounds as dual atx/ca inhibitors |