JP2018508537A5 - - Google Patents
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- JP2018508537A5 JP2018508537A5 JP2017546856A JP2017546856A JP2018508537A5 JP 2018508537 A5 JP2018508537 A5 JP 2018508537A5 JP 2017546856 A JP2017546856 A JP 2017546856A JP 2017546856 A JP2017546856 A JP 2017546856A JP 2018508537 A5 JP2018508537 A5 JP 2018508537A5
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- JP
- Japan
- Prior art keywords
- compound
- salt
- formula
- base
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 9
- 150000003839 salts Chemical group 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 150000001412 amines Chemical class 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 239000007858 starting material Substances 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- IXXFZUPTQVDPPK-ZAWHAJPISA-N (1r,2r,4r,6r,7r,8r,10s,13r,14s)-17-[4-[4-(3-aminophenyl)triazol-1-yl]butyl]-7-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-10-fluoro-6-methoxy-2,4,6,8,10,14-hexamethyl-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tet Chemical compound O([C@@H]1[C@@H](C)C(=O)[C@](C)(F)C(=O)O[C@@H]([C@]2(OC(=O)N(CCCCN3N=NC(=C3)C=3C=C(N)C=CC=3)[C@@H]2[C@@H](C)C(=O)[C@H](C)C[C@@]1(C)OC)C)CC)[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O IXXFZUPTQVDPPK-ZAWHAJPISA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 150000004985 diamines Chemical class 0.000 claims 1
- 239000012025 fluorinating agent Substances 0.000 claims 1
- 239000012022 methylating agents Substances 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229950008588 solithromycin Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562129305P | 2015-03-06 | 2015-03-06 | |
| US62/129,305 | 2015-03-06 | ||
| PCT/US2016/021085 WO2016144833A1 (en) | 2015-03-06 | 2016-03-05 | Processes for preparing fluoroketolides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018508537A JP2018508537A (ja) | 2018-03-29 |
| JP2018508537A5 true JP2018508537A5 (enExample) | 2019-04-18 |
| JP6773672B2 JP6773672B2 (ja) | 2020-10-21 |
Family
ID=56880477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017546856A Active JP6773672B2 (ja) | 2015-03-06 | 2016-03-05 | フルオロケトライドを調製するための方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20180044365A1 (enExample) |
| EP (1) | EP3265100A4 (enExample) |
| JP (1) | JP6773672B2 (enExample) |
| KR (1) | KR20170133377A (enExample) |
| CN (1) | CN107405355A (enExample) |
| AU (1) | AU2016230027A1 (enExample) |
| BR (1) | BR112017019176A2 (enExample) |
| CA (1) | CA2978731A1 (enExample) |
| CL (1) | CL2017002255A1 (enExample) |
| CO (1) | CO2017010143A2 (enExample) |
| HK (1) | HK1247097A1 (enExample) |
| IL (1) | IL254306A0 (enExample) |
| MX (2) | MX2017011454A (enExample) |
| PE (1) | PE20180219A1 (enExample) |
| RU (1) | RU2017131253A (enExample) |
| SG (2) | SG11201707215XA (enExample) |
| TW (1) | TW201638102A (enExample) |
| WO (1) | WO2016144833A1 (enExample) |
| ZA (1) | ZA201706505B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5698979B2 (ja) | 2007-10-25 | 2015-04-08 | センプラ ファーマシューティカルズ，インコーポレイテッド | マクロライド系抗菌剤の調製プロセス |
| EP2358379B1 (en) | 2008-10-24 | 2015-12-16 | Cempra Pharmaceuticals, Inc. | Biodefenses using triazole-containing macrolides |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| JP6208742B2 (ja) | 2012-03-27 | 2017-10-04 | センプラ ファーマシューティカルズ，インコーポレイテッド | マクロライド抗生物質を投与するための非経口製剤 |
| US9861616B2 (en) | 2013-03-14 | 2018-01-09 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3668282A (en) * | 1970-05-08 | 1972-06-06 | Stauffer Chemical Co | Stabilized mixture employing n-(beta-0,0-dialkyldithiophosphoryl) aryl sulfonamides |
| EP2772254A3 (en) * | 2003-03-10 | 2015-03-11 | Optimer Pharmaceuticals, Inc. | Novel Antibacterial Agents |
| US7595300B2 (en) * | 2005-12-13 | 2009-09-29 | Kosan Biosciences Incorporated | 7-quinolyl ketolide antibacterial agents |
| JP5698979B2 (ja) * | 2007-10-25 | 2015-04-08 | センプラ ファーマシューティカルズ，インコーポレイテッド | マクロライド系抗菌剤の調製プロセス |
| US8376805B2 (en) * | 2008-07-24 | 2013-02-19 | Ideo Llc | Printable pre-sewn stuffed toy composite sheets |
| EP2681222B1 (en) * | 2011-03-01 | 2018-02-28 | Wockhardt Limited | Process for preparation of ketolide intermediates |
| US9861616B2 (en) * | 2013-03-14 | 2018-01-09 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
| US9751908B2 (en) * | 2013-03-15 | 2017-09-05 | Cempra Pharmaceuticals, Inc. | Convergent processes for preparing macrolide antibacterial agents |
| BR112015025159A2 (pt) * | 2013-04-04 | 2017-07-18 | Harvard College | macrolídeos e métodos de sua preparação e uso |
-
2016
- 2016-03-05 WO PCT/US2016/021085 patent/WO2016144833A1/en not_active Ceased
- 2016-03-05 JP JP2017546856A patent/JP6773672B2/ja active Active
- 2016-03-05 KR KR1020177028547A patent/KR20170133377A/ko not_active Withdrawn
- 2016-03-05 EP EP16762268.7A patent/EP3265100A4/en not_active Withdrawn
- 2016-03-05 CA CA2978731A patent/CA2978731A1/en not_active Abandoned
- 2016-03-05 MX MX2017011454A patent/MX2017011454A/es unknown
- 2016-03-05 AU AU2016230027A patent/AU2016230027A1/en not_active Abandoned
- 2016-03-05 BR BR112017019176A patent/BR112017019176A2/pt not_active Application Discontinuation
- 2016-03-05 PE PE2017001500A patent/PE20180219A1/es not_active Application Discontinuation
- 2016-03-05 US US15/555,701 patent/US20180044365A1/en not_active Abandoned
- 2016-03-05 SG SG11201707215XA patent/SG11201707215XA/en unknown
- 2016-03-05 SG SG10201908248P patent/SG10201908248PA/en unknown
- 2016-03-05 CN CN201680021207.4A patent/CN107405355A/zh active Pending
- 2016-03-05 HK HK18106628.7A patent/HK1247097A1/zh unknown
- 2016-03-05 RU RU2017131253A patent/RU2017131253A/ru unknown
- 2016-03-07 TW TW105106986A patent/TW201638102A/zh unknown
-
2017
- 2017-09-04 IL IL254306A patent/IL254306A0/en unknown
- 2017-09-06 CL CL2017002255A patent/CL2017002255A1/es unknown
- 2017-09-06 MX MX2020007742A patent/MX2020007742A/es unknown
- 2017-09-27 ZA ZA2017/06505A patent/ZA201706505B/en unknown
- 2017-10-05 CO CONC2017/0010143A patent/CO2017010143A2/es unknown
-
2020
- 2020-04-23 US US16/856,754 patent/US20210070797A1/en not_active Abandoned