JP2013525265A5 - - Google Patents
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- JP2013525265A5 JP2013525265A5 JP2012549044A JP2012549044A JP2013525265A5 JP 2013525265 A5 JP2013525265 A5 JP 2013525265A5 JP 2012549044 A JP2012549044 A JP 2012549044A JP 2012549044 A JP2012549044 A JP 2012549044A JP 2013525265 A5 JP2013525265 A5 JP 2013525265A5
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- JP
- Japan
- Prior art keywords
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- production method
- manufacturing
- compound represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- KRDOFMHJLWKXIU-UHFFFAOYSA-N ID11614 Chemical compound C1CNCCN1C1=NSC2=CC=CC=C12 KRDOFMHJLWKXIU-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 29
- 150000001875 compounds Chemical class 0.000 claims 18
- 229910019142 PO4 Inorganic materials 0.000 claims 5
- 125000002619 bicyclic group Chemical group 0.000 claims 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 5
- 239000010452 phosphate Substances 0.000 claims 5
- 239000002904 solvent Substances 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 4
- 125000002950 monocyclic group Chemical group 0.000 claims 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical group [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- -1 1,2-benzisothiazol-3-yl Chemical group 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 150000007529 inorganic bases Chemical class 0.000 claims 3
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- 125000005947 C1-C6 alkylsulfonyloxy group Chemical group 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 239000006227 byproduct Substances 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 claims 1
- 150000008041 alkali metal carbonates Chemical class 0.000 claims 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 claims 1
- 125000005110 aryl thio group Chemical group 0.000 claims 1
- 125000005587 carbonate group Chemical group 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000004465 cycloalkenyloxy group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000005366 cycloalkylthio group Chemical group 0.000 claims 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical group [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000005368 heteroarylthio group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000005948 methanesulfonyloxy group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000004149 thio group Chemical group *S* 0.000 claims 1
- 0 C1*CCNC1 Chemical compound C1*CCNC1 0.000 description 6
- YZDLKGSISFGIRU-UHFFFAOYSA-N C(C1C(C2)CCCC1)[N]2(CC1)CCN1c1n[s]c2ccccc12 Chemical compound C(C1C(C2)CCCC1)[N]2(CC1)CCN1c1n[s]c2ccccc12 YZDLKGSISFGIRU-UHFFFAOYSA-N 0.000 description 1
- RIVOBMOBWMOLDJ-UHFFFAOYSA-N O=C(C1C2C3CC1CC3)NC2=O Chemical compound O=C(C1C2C3CC1CC3)NC2=O RIVOBMOBWMOLDJ-UHFFFAOYSA-N 0.000 description 1
- RIVOBMOBWMOLDJ-RNGGSSJXSA-N O=C([C@H]1[C@@H]2[C@H]3C[C@@H]1CC3)NC2=O Chemical compound O=C([C@H]1[C@@H]2[C@H]3C[C@@H]1CC3)NC2=O RIVOBMOBWMOLDJ-RNGGSSJXSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32780410P | 2010-04-26 | 2010-04-26 | |
| US61/327,804 | 2010-04-26 | ||
| PCT/JP2011/060571 WO2011136384A1 (en) | 2010-04-26 | 2011-04-25 | A process of a quaternary ammonium salt using phosphate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013525265A JP2013525265A (ja) | 2013-06-20 |
| JP2013525265A5 true JP2013525265A5 (enExample) | 2014-05-22 |
| JP5820822B2 JP5820822B2 (ja) | 2015-11-24 |
Family
ID=44816341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012549044A Active JP5820822B2 (ja) | 2010-04-26 | 2011-04-25 | リン酸塩を用いる第四級アンモニウム塩の製造法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8586737B2 (enExample) |
| EP (1) | EP2563791B1 (enExample) |
| JP (1) | JP5820822B2 (enExample) |
| ES (1) | ES2527545T3 (enExample) |
| WO (1) | WO2011136384A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5820821B2 (ja) * | 2010-04-26 | 2015-11-24 | 大日本住友製薬株式会社 | 第四級アンモニウム塩の製造法 |
| JP5820822B2 (ja) * | 2010-04-26 | 2015-11-24 | 大日本住友製薬株式会社 | リン酸塩を用いる第四級アンモニウム塩の製造法 |
| WO2013121440A1 (en) | 2012-02-13 | 2013-08-22 | Cadila Healthcare Limited | Process for preparing benzisothiazol-3-yl-peperazin-l-yl-methyl-cyclo hexyl-methanisoindol-1,3-dione and its intermediates |
| CN102746289B (zh) * | 2012-04-28 | 2016-06-08 | 上海医药工业研究院 | 一种盐酸卢拉西酮的制备方法 |
| CN103450172A (zh) * | 2012-05-30 | 2013-12-18 | 广州药源生物医药科技有限公司 | 一种抗精神病药物鲁拉西酮的制备方法 |
| CN102863437A (zh) * | 2012-09-04 | 2013-01-09 | 济南百诺医药科技开发有限公司 | 一种鲁拉西酮的制备方法 |
| CN103864774B (zh) * | 2012-12-14 | 2016-09-28 | 成都弘达药业有限公司 | 一种鲁拉西酮的制备方法 |
| ITMI20130262A1 (it) * | 2013-02-22 | 2014-08-23 | Edmond Pharma Srl | Procedimento per la preparazione di lurasidone cloridrato |
| ITMI20131245A1 (it) * | 2013-07-24 | 2015-01-25 | Olon Spa | Procedimento per la produzione di lurasidone ad elevata purezza |
| ITMI20131737A1 (it) | 2013-10-17 | 2015-04-18 | Procos Spa | Processo per la sintesi industriale di lurasidone |
| HUE052277T2 (hu) | 2014-06-16 | 2021-04-28 | Johnson Matthey Plc | Eljárások alkilezett arilpiperazin és alkilezett arilpiperidin vegyületek elõállítására, és új intermedierek |
| US10426770B2 (en) | 2014-10-14 | 2019-10-01 | Jubilant Generics Limited | Process for the preparation of Lurasidone hydrochloride |
| EP3242876A4 (en) * | 2015-01-08 | 2019-01-02 | Piramal Enterprises Limited | An improved process for the preparation of lurasidone and its intermediate |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4351939A (en) * | 1980-10-16 | 1982-09-28 | Mead Johnson & Company | Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process |
| JP2800953B2 (ja) * | 1990-07-06 | 1998-09-21 | 住友製薬株式会社 | 新規なイミド誘導体 |
| FR2665161B1 (fr) * | 1990-07-26 | 1992-11-27 | Esteve Labor Dr | Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments. |
| JP3775823B2 (ja) * | 1995-06-09 | 2006-05-17 | 大日本住友製薬株式会社 | 新規なイミド誘導体 |
| JP4175800B2 (ja) * | 2001-11-27 | 2008-11-05 | 住友化学株式会社 | イミド誘導体の製造方法 |
| JP2006169154A (ja) * | 2004-12-15 | 2006-06-29 | Sumitomo Chemical Co Ltd | 第四級アンモニウム塩の製造方法 |
| JP4708012B2 (ja) * | 2004-12-15 | 2011-06-22 | 大日本住友製薬株式会社 | 第四級アンモニウム塩の製造法 |
| CN101300260B (zh) * | 2005-08-30 | 2012-05-09 | 霍尼韦尔国际公司 | 合成螺环季铵体系的方法 |
| US20110003994A1 (en) * | 2009-07-02 | 2011-01-06 | Dainippon Sumitomo Pharma Co., Ltd. | Cycloalkane derivative |
| JP5820821B2 (ja) | 2010-04-26 | 2015-11-24 | 大日本住友製薬株式会社 | 第四級アンモニウム塩の製造法 |
| JP5820822B2 (ja) * | 2010-04-26 | 2015-11-24 | 大日本住友製薬株式会社 | リン酸塩を用いる第四級アンモニウム塩の製造法 |
-
2011
- 2011-04-25 JP JP2012549044A patent/JP5820822B2/ja active Active
- 2011-04-25 WO PCT/JP2011/060571 patent/WO2011136384A1/en not_active Ceased
- 2011-04-25 EP EP11775165.1A patent/EP2563791B1/en active Active
- 2011-04-25 ES ES11775165.1T patent/ES2527545T3/es active Active
- 2011-04-26 US US13/093,985 patent/US8586737B2/en active Active
-
2013
- 2013-09-30 US US14/041,657 patent/US20140031548A1/en not_active Abandoned
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