JP2017122107A5 - - Google Patents
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- Publication number
- JP2017122107A5 JP2017122107A5 JP2017034914A JP2017034914A JP2017122107A5 JP 2017122107 A5 JP2017122107 A5 JP 2017122107A5 JP 2017034914 A JP2017034914 A JP 2017034914A JP 2017034914 A JP2017034914 A JP 2017034914A JP 2017122107 A5 JP2017122107 A5 JP 2017122107A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- salt
- compound
- process according
- xiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000003839 salts Chemical class 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical group ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 claims 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical group [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 239000007822 coupling agent Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- ZCIGNRJZKPOIKD-CQXVEOKZSA-N CC(C)c1nc(CN(C)C(N[C@@H](CCN2CCOCC2)C(N[C@H](CC[C@H](Cc2ccccc2)NC(OCc2cnc[s]2)=O)Cc2ccccc2)=O)=O)c[s]1 Chemical compound CC(C)c1nc(CN(C)C(N[C@@H](CCN2CCOCC2)C(N[C@H](CC[C@H](Cc2ccccc2)NC(OCc2cnc[s]2)=O)Cc2ccccc2)=O)=O)c[s]1 ZCIGNRJZKPOIKD-CQXVEOKZSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16649809P | 2009-04-03 | 2009-04-03 | |
| US61/166,498 | 2009-04-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016014135A Division JP6180561B2 (ja) | 2009-04-03 | 2016-01-28 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤およびそれに関わる中間体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017146329A Division JP6491706B2 (ja) | 2009-04-03 | 2017-07-28 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤およびそれに関わる中間体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017122107A JP2017122107A (ja) | 2017-07-13 |
| JP2017122107A5 true JP2017122107A5 (enExample) | 2017-09-07 |
| JP6336161B2 JP6336161B2 (ja) | 2018-06-06 |
Family
ID=42634770
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012503704A Active JP5612662B2 (ja) | 2009-04-03 | 2010-04-01 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤およびそれに関わる中間体 |
| JP2014104007A Active JP5986599B2 (ja) | 2009-04-03 | 2014-05-20 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤を調製する方法および関わる中間体 |
| JP2016014135A Active JP6180561B2 (ja) | 2009-04-03 | 2016-01-28 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤およびそれに関わる中間体 |
| JP2017034914A Active JP6336161B2 (ja) | 2009-04-03 | 2017-02-27 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤およびそれに関わる中間体 |
| JP2017146329A Active JP6491706B2 (ja) | 2009-04-03 | 2017-07-28 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤およびそれに関わる中間体 |
| JP2018115527A Withdrawn JP2018162274A (ja) | 2009-04-03 | 2018-06-18 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤およびそれに関わる中間体 |
| JP2020134426A Withdrawn JP2020189861A (ja) | 2009-04-03 | 2020-08-07 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤およびそれに関わる中間体 |
| JP2022167506A Withdrawn JP2023002679A (ja) | 2009-04-03 | 2022-10-19 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤およびそれに関わる中間体 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012503704A Active JP5612662B2 (ja) | 2009-04-03 | 2010-04-01 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤およびそれに関わる中間体 |
| JP2014104007A Active JP5986599B2 (ja) | 2009-04-03 | 2014-05-20 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤を調製する方法および関わる中間体 |
| JP2016014135A Active JP6180561B2 (ja) | 2009-04-03 | 2016-01-28 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤およびそれに関わる中間体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017146329A Active JP6491706B2 (ja) | 2009-04-03 | 2017-07-28 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤およびそれに関わる中間体 |
| JP2018115527A Withdrawn JP2018162274A (ja) | 2009-04-03 | 2018-06-18 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤およびそれに関わる中間体 |
| JP2020134426A Withdrawn JP2020189861A (ja) | 2009-04-03 | 2020-08-07 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤およびそれに関わる中間体 |
| JP2022167506A Withdrawn JP2023002679A (ja) | 2009-04-03 | 2022-10-19 | チトクロームｐ４５０モノオキシゲナーゼの阻害剤およびそれに関わる中間体 |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US8497396B2 (enExample) |
| EP (2) | EP3009434A1 (enExample) |
| JP (8) | JP5612662B2 (enExample) |
| KR (3) | KR101874557B1 (enExample) |
| CN (4) | CN111217808A (enExample) |
| AP (1) | AP2887A (enExample) |
| AR (1) | AR076027A1 (enExample) |
| AU (1) | AU2010232559B2 (enExample) |
| BR (1) | BRPI1012638B8 (enExample) |
| CA (4) | CA2925137C (enExample) |
| CL (1) | CL2011002370A1 (enExample) |
| CO (1) | CO6400216A2 (enExample) |
| EA (2) | EA022739B1 (enExample) |
| EC (1) | ECSP11011391A (enExample) |
| ES (1) | ES2548252T3 (enExample) |
| HK (1) | HK1223912A1 (enExample) |
| IL (4) | IL215399A (enExample) |
| MX (2) | MX338731B (enExample) |
| NZ (4) | NZ594864A (enExample) |
| PE (1) | PE20120617A1 (enExample) |
| PT (1) | PT2414325E (enExample) |
| SG (2) | SG174585A1 (enExample) |
| TW (2) | TWI464165B (enExample) |
| UA (1) | UA108738C2 (enExample) |
| UY (1) | UY32535A (enExample) |
| WO (1) | WO2010115000A2 (enExample) |
| ZA (1) | ZA201107430B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA108738C2 (uk) | 2009-04-03 | 2015-06-10 | Спосіб одержання інгібітора цитохром р450 монооксигенази та залучені проміжні сполуки | |
| JP2012140390A (ja) * | 2011-01-06 | 2012-07-26 | Sumitomo Chemical Co Ltd | α−アミノ−γ−ブチロラクトンの製造方法 |
| PT2705027E (pt) * | 2011-05-02 | 2015-09-11 | Gilead Sciences Inc | Sais sólido de amorfo de cobicistat (gs-9350) |
| CN104093702A (zh) | 2012-02-03 | 2014-10-08 | 吉里德科学公司 | 用于制备药物试剂的方法和中间体 |
| CN103694196A (zh) * | 2012-09-27 | 2014-04-02 | 上海迪赛诺化学制药有限公司 | 细胞色素p450单加氧酶抑制剂中间体及其制法和用途 |
| WO2014047849A1 (zh) * | 2012-09-27 | 2014-04-03 | 上海迪赛诺化学制药有限公司 | 细胞色素p450单加氧酶抑制剂中间体及其制法和用途 |
| WO2014057498A2 (en) | 2012-10-08 | 2014-04-17 | Mylan Laboratories Ltd. | Process for the preparation of cobicistat intermediates |
| JP2016504364A (ja) * | 2012-12-26 | 2016-02-12 | アッシア・ケミカル・インダストリーズ・リミテッド | コビシスタット塩 |
| CN104370777A (zh) * | 2013-08-13 | 2015-02-25 | 上海迪赛诺化学制药有限公司 | 合成(2r,5r)-1,6-二苯基己烷-2,5-二胺及其盐的中间体及所述中间体的制备方法和应用 |
| WO2015079415A1 (en) * | 2013-11-29 | 2015-06-04 | Mylan Laboratories Ltd. | Amorphous cobicistat solid dispersion |
| WO2015083066A1 (en) | 2013-12-03 | 2015-06-11 | Mylan Laboratories Ltd. | Preparation of cobicistat intermediates |
| CN104193643B (zh) * | 2014-09-12 | 2016-02-10 | 宁波九胜创新医药科技有限公司 | 用于合成抗艾滋病药物增强剂cobicistat的中间体 |
| CN104447472A (zh) * | 2014-11-06 | 2015-03-25 | 江苏森萱医药化工股份有限公司 | D)-2-苄基-n,n-二甲基氮杂环丙烷基-1-磺酰胺合成方法 |
| CN104557565B (zh) * | 2015-01-08 | 2016-07-06 | 浙江工业大学 | 抗艾滋病药物增强剂Cobicistat关键中间体盐酸盐的制备方法 |
| WO2016128885A1 (en) * | 2015-02-09 | 2016-08-18 | Laurus Labs Private Limited | A process for preparation of cobicistat |
| US10351556B2 (en) | 2015-02-18 | 2019-07-16 | Msn Laboratories Private Limited | Process for the preparation of 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2s)-2-[(methyl{[2-(propan-2-yl)-1,3-thiazol-4YL] methyl} carbamoyl) amino]-4-(morpholin-4-yl)butanoyl]amino)-1,6-diphenylhexan-2-yl]carbamate |
| CN107674039A (zh) * | 2016-08-01 | 2018-02-09 | 上海朴颐化学科技有限公司 | 一种可比西他中间体的制备方法 |
| WO2018064071A1 (en) | 2016-09-27 | 2018-04-05 | Gilead Sciences, Inc. | Therapeutic compositions for treatment of human immunodeficiency virus |
| CN109912530A (zh) * | 2017-12-13 | 2019-06-21 | 上海奥博生物医药技术有限公司 | 一种可比司他原料杂质的制备方法 |
| CN109232301B (zh) * | 2018-10-15 | 2021-01-01 | 天津希恩思生化科技有限公司 | 一种四异丙基肼的制备方法 |
| CN110642721B (zh) * | 2018-12-21 | 2022-09-30 | 安徽贝克生物制药有限公司 | 盐酸司来吉兰的制备方法 |
| CN110878071A (zh) * | 2019-11-21 | 2020-03-13 | 华南农业大学 | 一种α-氨基-γ-丁内酯及其盐的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK286305B6 (en) * | 1999-06-04 | 2008-07-07 | Abbott Laboratoires | Improved pharmaceutical formulations comprising ritonavir |
| US20030153771A1 (en) | 2001-09-27 | 2003-08-14 | Kolb Hartmuth C. | Large scale synthesis of optically pure aziridines |
| AU2003232173A1 (en) * | 2002-06-12 | 2003-12-31 | Qsi Pharma A/S | Compounds and methods for controlling bacterial virulence |
| EP1771536A1 (en) * | 2004-07-23 | 2007-04-11 | The Procter and Gamble Company | Liquid detergent composition for improved low temperature grease cleaning and starch soil cleaning |
| US7786153B2 (en) * | 2005-03-02 | 2010-08-31 | Abbott Laboratories Inc. | Compounds that are useful for improving pharmacokinetics |
| AU2007275860C1 (en) * | 2006-07-07 | 2014-06-12 | Gilead Sciences, Inc. | Modulators of pharmacokinetic properties of therapeutics |
| ES2602784T3 (es) * | 2007-02-23 | 2017-02-22 | Gilead Sciences, Inc. | Moduladores de las propiedades farmacocinéticas de los agentes terapéuticos |
| CN101796040A (zh) * | 2007-07-06 | 2010-08-04 | 吉里德科学公司 | 治疗剂的药代动力学特性调节剂 |
| JP5629585B2 (ja) * | 2008-01-04 | 2014-11-19 | ギリアード サイエンシーズ， インコーポレイテッド | シトクロムｐ４５０のインヒビター |
| HRP20151357T1 (hr) | 2008-05-02 | 2016-01-29 | Gilead Sciences, Inc. | Upotreba äśestica äśvrstog nosaäśa kako bi se poboljšala procesabilnost farmaceutskog agensa |
| UA108738C2 (uk) | 2009-04-03 | 2015-06-10 | Спосіб одержання інгібітора цитохром р450 монооксигенази та залучені проміжні сполуки |
-
2010
- 2010-01-04 UA UAA201111540A patent/UA108738C2/ru unknown
- 2010-03-31 AR ARP100101077 patent/AR076027A1/es unknown
- 2010-03-31 TW TW99109929A patent/TWI464165B/zh active
- 2010-03-31 TW TW103133537A patent/TW201518283A/zh unknown
- 2010-04-01 WO PCT/US2010/029633 patent/WO2010115000A2/en not_active Ceased
- 2010-04-01 KR KR1020177009970A patent/KR101874557B1/ko active Active
- 2010-04-01 CA CA2925137A patent/CA2925137C/en active Active
- 2010-04-01 SG SG2011069937A patent/SG174585A1/en unknown
- 2010-04-01 BR BRPI1012638A patent/BRPI1012638B8/pt active IP Right Grant
- 2010-04-01 CN CN202010112624.8A patent/CN111217808A/zh active Pending
- 2010-04-01 MX MX2013003678A patent/MX338731B/es unknown
- 2010-04-01 CN CN201510160505.9A patent/CN104876888B/zh active Active
- 2010-04-01 NZ NZ59486410A patent/NZ594864A/en unknown
- 2010-04-01 CA CA3008903A patent/CA3008903C/en active Active
- 2010-04-01 EA EA201190179A patent/EA022739B1/ru unknown
- 2010-04-01 CN CN201710518109.8A patent/CN107382997B/zh active Active
- 2010-04-01 EP EP15171216.3A patent/EP3009434A1/en not_active Withdrawn
- 2010-04-01 KR KR1020187018487A patent/KR20180077324A/ko not_active Ceased
- 2010-04-01 US US12/752,639 patent/US8497396B2/en active Active
- 2010-04-01 CN CN201080014307.7A patent/CN102438982B/zh active Active
- 2010-04-01 AU AU2010232559A patent/AU2010232559B2/en active Active
- 2010-04-01 KR KR1020117026120A patent/KR101728375B1/ko active Active
- 2010-04-01 CA CA2754698A patent/CA2754698C/en active Active
- 2010-04-01 NZ NZ708978A patent/NZ708978A/en unknown
- 2010-04-01 EP EP10713075.9A patent/EP2414325B1/en active Active
- 2010-04-01 NZ NZ617773A patent/NZ617773A/en unknown
- 2010-04-01 PT PT107130759T patent/PT2414325E/pt unknown
- 2010-04-01 SG SG10201404926UA patent/SG10201404926UA/en unknown
- 2010-04-01 PE PE2011001737A patent/PE20120617A1/es active IP Right Grant
- 2010-04-01 ES ES10713075.9T patent/ES2548252T3/es active Active
- 2010-04-01 NZ NZ726536A patent/NZ726536A/en unknown
- 2010-04-01 JP JP2012503704A patent/JP5612662B2/ja active Active
- 2010-04-01 AP AP2011005864A patent/AP2887A/xx active
- 2010-04-01 MX MX2011010397A patent/MX2011010397A/es active IP Right Grant
- 2010-04-01 EA EA201590979A patent/EA201590979A1/ru unknown
- 2010-04-01 CA CA3083433A patent/CA3083433C/en active Active
- 2010-04-05 UY UY32535A patent/UY32535A/es not_active Application Discontinuation
-
2011
- 2011-09-06 CO CO11114749A patent/CO6400216A2/es not_active Application Discontinuation
- 2011-09-26 CL CL2011002370A patent/CL2011002370A1/es unknown
- 2011-09-27 IL IL215399A patent/IL215399A/en active IP Right Grant
- 2011-10-11 ZA ZA2011/07430A patent/ZA201107430B/en unknown
- 2011-10-12 EC ECSP11011391 patent/ECSP11011391A/es unknown
-
2013
- 2013-06-24 US US13/925,302 patent/US8853210B2/en active Active
-
2014
- 2014-05-20 JP JP2014104007A patent/JP5986599B2/ja active Active
- 2014-09-03 US US14/476,622 patent/US9115100B2/en active Active
-
2015
- 2015-03-10 IL IL237642A patent/IL237642A/en active IP Right Grant
- 2015-03-10 IL IL237643A patent/IL237643A/en active IP Right Grant
- 2015-07-14 US US14/799,090 patent/US9428473B2/en active Active
-
2016
- 2016-01-28 JP JP2016014135A patent/JP6180561B2/ja active Active
- 2016-09-09 HK HK16110713.7A patent/HK1223912A1/en unknown
-
2017
- 2017-01-11 IL IL250068A patent/IL250068A0/en unknown
- 2017-02-27 JP JP2017034914A patent/JP6336161B2/ja active Active
- 2017-07-28 JP JP2017146329A patent/JP6491706B2/ja active Active
-
2018
- 2018-06-18 JP JP2018115527A patent/JP2018162274A/ja not_active Withdrawn
-
2020
- 2020-08-07 JP JP2020134426A patent/JP2020189861A/ja not_active Withdrawn
-
2022
- 2022-10-19 JP JP2022167506A patent/JP2023002679A/ja not_active Withdrawn
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