JP2020114842A5 - - Google Patents
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- JP2020114842A5 JP2020114842A5 JP2020052658A JP2020052658A JP2020114842A5 JP 2020114842 A5 JP2020114842 A5 JP 2020114842A5 JP 2020052658 A JP2020052658 A JP 2020052658A JP 2020052658 A JP2020052658 A JP 2020052658A JP 2020114842 A5 JP2020114842 A5 JP 2020114842A5
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- JP
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- Prior art keywords
- compound
- organic solvent
- range
- cuprous
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C*(C)c(cc1)cc*1C(Oc1ccccc1)=N Chemical compound C*(C)c(cc1)cc*1C(Oc1ccccc1)=N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462094436P | 2014-12-19 | 2014-12-19 | |
| US62/094,436 | 2014-12-19 | ||
| JP2017532725A JP6681902B2 (ja) | 2014-12-19 | 2015-12-17 | ジアリールチオヒダントイン化合物を調製するためのプロセス |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017532725A Division JP6681902B2 (ja) | 2014-12-19 | 2015-12-17 | ジアリールチオヒダントイン化合物を調製するためのプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020114842A JP2020114842A (ja) | 2020-07-30 |
| JP2020114842A5 true JP2020114842A5 (enExample) | 2020-11-12 |
| JP6903785B2 JP6903785B2 (ja) | 2021-07-14 |
Family
ID=55168400
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017532725A Active JP6681902B2 (ja) | 2014-12-19 | 2015-12-17 | ジアリールチオヒダントイン化合物を調製するためのプロセス |
| JP2020052658A Active JP6903785B2 (ja) | 2014-12-19 | 2020-03-24 | ジアリールチオヒダントイン化合物を調製するためのプロセス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017532725A Active JP6681902B2 (ja) | 2014-12-19 | 2015-12-17 | ジアリールチオヒダントイン化合物を調製するためのプロセス |
Country Status (33)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3233803T (lt) * | 2014-12-19 | 2019-04-10 | Aragon Pharmaceuticals, Inc. | Diariltiohidantoino junginio gamybos būdas |
| MX383748B (es) | 2014-12-19 | 2025-03-14 | Aragon Pharmaceuticals Inc | Procesos para la preparación de un compuesto de diariltiohidantoína. |
| CN108069869B (zh) * | 2016-11-09 | 2022-03-01 | 上海医药工业研究院 | 一种Apalutamide的制备方法及其中间体 |
| TW201831461A (zh) * | 2017-01-18 | 2018-09-01 | 台灣神隆股份有限公司 | 製備阿帕魯醯胺的方法 |
| US10364245B2 (en) | 2017-06-07 | 2019-07-30 | Chiesi Farmaceutici S.P.A. | Kinase inhibitors |
| CN107501237B (zh) * | 2017-08-17 | 2022-03-22 | 上海西浦医药科技有限公司 | 一种Apalutamide的合成方法 |
| CN108383749B (zh) * | 2018-01-30 | 2021-03-09 | 杭州科巢生物科技有限公司 | 阿帕鲁胺的合成方法及其中间体 |
| US10513504B2 (en) | 2018-03-08 | 2019-12-24 | Apotex Inc. | Processes for the preparation of apalutamide and intermediates thereof |
| CN108314646B (zh) * | 2018-04-11 | 2021-03-19 | 武汉慧敏科技中心 | 一种高分散双金属纳米材料制备泌尿生殖系统用药物中间体的方法 |
| CN109651256A (zh) * | 2018-11-20 | 2019-04-19 | 上海健康医学院 | 一种式（viii）的恩杂鲁胺的制备方法 |
| CN110511206A (zh) * | 2019-06-17 | 2019-11-29 | 扬子江药业集团江苏海慈生物药业有限公司 | 芳基-2-硫代海因类化合物中间体、其制备方法及应用 |
| CN110511207A (zh) * | 2019-06-17 | 2019-11-29 | 扬子江药业集团江苏海慈生物药业有限公司 | 芳基-2-硫代海因类化合物中间体、其制备方法及应用 |
| CN113968815B (zh) * | 2020-07-24 | 2025-11-18 | 苏州科伦药物研究有限公司 | 一种硫代二氮杂螺类化合物的合成方法、其中间体及其合成方法 |
| US12606539B2 (en) | 2020-09-04 | 2026-04-21 | Synthon B.V. | Process for preparation of apalutamide |
| MX2023005823A (es) * | 2020-11-20 | 2023-05-31 | Amgen Inc | Procedimiento para preparar 7-cloro-6-fluoro-1-(2-isopropil-4-meti lpiridin-3-il)pirido[2,3-d]pirimidino-2,4(1h,3h)-diona. |
| CN113292535B (zh) * | 2021-06-18 | 2022-07-01 | 南京方生和医药科技有限公司 | 一种制备阿帕鲁胺中间体及阿帕鲁胺的方法 |
| CN113402466B (zh) * | 2021-06-18 | 2022-08-16 | 南京方生和医药科技有限公司 | 一种阿帕鲁胺中间体及制备阿帕鲁胺的方法 |
| CN115572264B (zh) * | 2021-07-06 | 2025-12-05 | 山东新时代药业有限公司 | 一种恩杂鲁胺的制备方法 |
| CN115850233B (zh) * | 2021-09-24 | 2024-12-10 | 南京方生和医药科技有限公司 | 一种阿帕鲁胺的合成方法 |
| CN116239536A (zh) * | 2021-12-08 | 2023-06-09 | 山东新时代药业有限公司 | 一种阿帕鲁胺中间体化合物 |
| CN117534652B (zh) * | 2022-08-02 | 2026-07-28 | 黄冈人福药业有限责任公司 | 一种阿帕他胺的制备方法 |
| CN115536634B (zh) * | 2022-10-17 | 2024-06-11 | 上海博悦生物科技有限公司 | 一种阿帕他胺的合成方法 |
| CN116332907A (zh) * | 2023-03-16 | 2023-06-27 | 奥锐特药业股份有限公司 | 一种无定形阿帕他胺的制备方法 |
| CN117986185A (zh) * | 2023-06-28 | 2024-05-07 | 广东东阳光药业股份有限公司 | 一种阿帕他胺的制备方法 |
| CN117645572A (zh) * | 2023-11-23 | 2024-03-05 | 奥锐特药业股份有限公司 | 恩扎卢胺及其中间体的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040077605A1 (en) * | 2001-06-20 | 2004-04-22 | Salvati Mark E. | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
| TWI263640B (en) * | 2001-12-19 | 2006-10-11 | Bristol Myers Squibb Co | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
| BRPI0709771B1 (pt) * | 2006-03-27 | 2022-01-25 | The Regents Of The University Of California | Composto e composição farmacêutica |
| US8461343B2 (en) * | 2007-03-27 | 2013-06-11 | Sloan-Kettering Institute For Cancer Research | Synthesis of thiohydantoins |
| JP5513492B2 (ja) * | 2008-05-16 | 2014-06-04 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤 |
| EP2509961B1 (en) | 2009-12-11 | 2016-03-09 | Autifony Therapeutics Limited | Imidazolidinedione derivatives |
| EP3124481B1 (en) * | 2010-02-16 | 2018-03-28 | Aragon Pharmaceuticals, Inc. | Androgen receptor modulators and uses thereof |
| RU2554081C2 (ru) * | 2010-02-24 | 2015-06-27 | Медивэйшн Простейт Терапьютикс, Инк. | Способ синтеза соединений диарилтиогидантоина и диарилгидантоина |
| WO2012119559A1 (en) | 2011-03-10 | 2012-09-13 | Suzhou Kintor Pharmaceuticals,Inc. | Androgen receptor antagonists and uses thereof |
| WO2013029338A1 (en) * | 2011-09-01 | 2013-03-07 | Glaxo Group Limited | Novel compounds |
| CN109731098A (zh) * | 2012-03-29 | 2019-05-10 | 桑加特公司 | 双阿司匹林交联聚乙二醇化血红蛋白 |
| ES2940901T3 (es) * | 2013-05-29 | 2023-05-12 | Hinova Pharmaceuticals Inc | Compuesto de imidazol dicetona y uso del mismo |
| LT3233803T (lt) * | 2014-12-19 | 2019-04-10 | Aragon Pharmaceuticals, Inc. | Diariltiohidantoino junginio gamybos būdas |
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2015
- 2015-12-17 LT LTEP15823875.8T patent/LT3233803T/lt unknown
- 2015-12-17 MX MX2017008179A patent/MX375467B/es active IP Right Grant
- 2015-12-17 TR TR2019/04739T patent/TR201904739T4/tr unknown
- 2015-12-17 RS RS20201378A patent/RS61060B9/sr unknown
- 2015-12-17 HU HUE18169756A patent/HUE052475T2/hu unknown
- 2015-12-17 PL PL18169895.2T patent/PL3372585T3/pl unknown
- 2015-12-17 DK DK15823875.8T patent/DK3233803T3/en active
- 2015-12-17 EA EA201791390A patent/EA201791390A1/ru unknown
- 2015-12-17 SG SG10201912802XA patent/SG10201912802XA/en unknown
- 2015-12-17 PL PL18169756T patent/PL3372584T3/pl unknown
- 2015-12-17 ES ES15823875T patent/ES2718539T3/es active Active
- 2015-12-17 RS RS20220542A patent/RS63455B1/sr unknown
- 2015-12-17 ME MEP-2019-86A patent/ME03420B/me unknown
- 2015-12-17 ES ES18169756T patent/ES2827549T3/es active Active
- 2015-12-17 EA EA201892485A patent/EA201892485A1/ru unknown
- 2015-12-17 SM SM20190208T patent/SMT201900208T1/it unknown
- 2015-12-17 BR BR112017013113-7A patent/BR112017013113B1/pt active IP Right Grant
- 2015-12-17 EA EA201892486A patent/EA201892486A1/ru unknown
- 2015-12-17 SI SI201530599T patent/SI3233803T1/sl unknown
- 2015-12-17 HR HRP20190540TT patent/HRP20190540T1/hr unknown
- 2015-12-17 PT PT15823875T patent/PT3233803T/pt unknown
- 2015-12-17 RS RS20190350A patent/RS58454B1/sr unknown
- 2015-12-17 EP EP18170050.1A patent/EP3372586A1/en not_active Withdrawn
- 2015-12-17 CN CN202410667649.2A patent/CN118638097A/zh active Pending
- 2015-12-17 SM SM20200618T patent/SMT202000618T1/it unknown
- 2015-12-17 SG SG10201912805SA patent/SG10201912805SA/en unknown
- 2015-12-17 DK DK18169756.6T patent/DK3372584T5/da active
- 2015-12-17 SI SI201531848T patent/SI3372585T1/sl unknown
- 2015-12-17 JP JP2017532725A patent/JP6681902B2/ja active Active
- 2015-12-17 PT PT181698952T patent/PT3372585T/pt unknown
- 2015-12-17 LT LTEP18169895.2T patent/LT3372585T/lt unknown
- 2015-12-17 CN CN201580069602.5A patent/CN107108507B/zh active Active
- 2015-12-17 WO PCT/US2015/066356 patent/WO2016100652A2/en not_active Ceased
- 2015-12-17 MD MDE20170208T patent/MD3233803T2/ro unknown
- 2015-12-17 SG SG11201704969QA patent/SG11201704969QA/en unknown
- 2015-12-17 EP EP18169895.2A patent/EP3372585B1/en active Active
- 2015-12-17 UA UAA201707588A patent/UA123201C2/uk unknown
- 2015-12-17 PT PT181697566T patent/PT3372584T/pt unknown
- 2015-12-17 PH PH1/2017/501152A patent/PH12017501152B1/en unknown
- 2015-12-17 AU AU2015364537A patent/AU2015364537B2/en active Active
- 2015-12-17 SM SM20220242T patent/SMT202200242T1/it unknown
- 2015-12-17 SI SI201531433T patent/SI3372584T1/sl unknown
- 2015-12-17 SG SG10201912811QA patent/SG10201912811QA/en unknown
- 2015-12-17 KR KR1020177019551A patent/KR102586059B1/ko active Active
- 2015-12-17 MA MA41200A patent/MA41200B1/fr unknown
- 2015-12-17 HU HUE15823875A patent/HUE042409T2/hu unknown
- 2015-12-17 HR HRP20220750TT patent/HRP20220750T1/hr unknown
- 2015-12-17 IL IL252843A patent/IL252843B2/en unknown
- 2015-12-17 ES ES18169895T patent/ES2919951T3/es active Active
- 2015-12-17 PL PL15823875T patent/PL3233803T3/pl unknown
- 2015-12-17 EA EA201892487A patent/EA201892487A1/ru unknown
- 2015-12-17 US US14/973,089 patent/US9688655B2/en active Active
- 2015-12-17 EP EP15823875.8A patent/EP3233803B1/en active Active
- 2015-12-17 EP EP18169756.6A patent/EP3372584B9/en active Active
- 2015-12-17 NZ NZ732766A patent/NZ732766A/en unknown
- 2015-12-17 LT LTEP18169756.6T patent/LT3372584T/lt unknown
- 2015-12-17 DK DK18169895.2T patent/DK3372585T3/da active
- 2015-12-18 TW TW108146841A patent/TWI753336B/zh active
- 2015-12-18 TW TW108131622A patent/TWI703132B/zh active
- 2015-12-18 TW TW104142692A patent/TWI683810B/zh active
- 2015-12-18 TW TW108131623A patent/TWI689494B/zh active
- 2015-12-21 AR ARP150104237A patent/AR103228A1/es active IP Right Grant
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2017
- 2017-07-18 ZA ZA2017/04877A patent/ZA201704877B/en unknown
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2019
- 2019-04-10 CY CY20191100400T patent/CY1121684T1/el unknown
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2020
- 2020-03-24 JP JP2020052658A patent/JP6903785B2/ja active Active
- 2020-11-02 CY CY20201101031T patent/CY1123611T1/el unknown
- 2020-11-20 HR HRP20201847TT patent/HRP20201847T2/hr unknown
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2022
- 2022-06-10 CY CY20221100408T patent/CY1125243T1/el unknown
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2024
- 2024-12-06 AR ARP240103372A patent/AR134579A2/es unknown
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