JP2018522018A5 - - Google Patents
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- JP2018522018A5 JP2018522018A5 JP2018502800A JP2018502800A JP2018522018A5 JP 2018522018 A5 JP2018522018 A5 JP 2018522018A5 JP 2018502800 A JP2018502800 A JP 2018502800A JP 2018502800 A JP2018502800 A JP 2018502800A JP 2018522018 A5 JP2018522018 A5 JP 2018522018A5
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- JP
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- Prior art keywords
- formula
- compound
- salt
- reacted
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562195023P | 2015-07-21 | 2015-07-21 | |
| US62/195,023 | 2015-07-21 | ||
| US201662327973P | 2016-04-26 | 2016-04-26 | |
| US62/327,973 | 2016-04-26 | ||
| PCT/US2016/043402 WO2017015495A1 (en) | 2015-07-21 | 2016-07-21 | Methods of preparing cytotoxic benzodiazepine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018522018A JP2018522018A (ja) | 2018-08-09 |
| JP2018522018A5 true JP2018522018A5 (enExample) | 2019-08-29 |
Family
ID=56557925
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502785A Expired - Fee Related JP6858745B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2018502800A Withdrawn JP2018522018A (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2018502791A Expired - Fee Related JP6787995B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2020180147A Expired - Fee Related JP6995178B2 (ja) | 2015-07-21 | 2020-10-28 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021049502A Active JP7337114B2 (ja) | 2015-07-21 | 2021-03-24 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021202215A Active JP7334228B2 (ja) | 2015-07-21 | 2021-12-14 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023132536A Withdrawn JP2023162264A (ja) | 2015-07-21 | 2023-08-16 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023134420A Withdrawn JP2023166434A (ja) | 2015-07-21 | 2023-08-22 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502785A Expired - Fee Related JP6858745B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502791A Expired - Fee Related JP6787995B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2020180147A Expired - Fee Related JP6995178B2 (ja) | 2015-07-21 | 2020-10-28 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021049502A Active JP7337114B2 (ja) | 2015-07-21 | 2021-03-24 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021202215A Active JP7334228B2 (ja) | 2015-07-21 | 2021-12-14 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023132536A Withdrawn JP2023162264A (ja) | 2015-07-21 | 2023-08-16 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023134420A Withdrawn JP2023166434A (ja) | 2015-07-21 | 2023-08-22 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (11) | US9873708B2 (enExample) |
| EP (7) | EP3778602B1 (enExample) |
| JP (8) | JP6858745B2 (enExample) |
| KR (5) | KR102660070B1 (enExample) |
| CN (5) | CN108055844A (enExample) |
| AU (7) | AU2016297607A1 (enExample) |
| CA (4) | CA2991326A1 (enExample) |
| CY (2) | CY1122553T1 (enExample) |
| DK (2) | DK3325483T3 (enExample) |
| ES (4) | ES2820358T3 (enExample) |
| HK (1) | HK1252322A1 (enExample) |
| HR (1) | HRP20201479T1 (enExample) |
| HU (1) | HUE051541T2 (enExample) |
| IL (10) | IL305989A (enExample) |
| LT (2) | LT3325483T (enExample) |
| PL (2) | PL3325483T3 (enExample) |
| PT (2) | PT3325482T (enExample) |
| RS (2) | RS60840B1 (enExample) |
| RU (3) | RU2018105752A (enExample) |
| SG (2) | SG10202009354SA (enExample) |
| SI (2) | SI3325483T1 (enExample) |
| SM (2) | SMT202000004T1 (enExample) |
| WO (3) | WO2017015502A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102660070B1 (ko) | 2015-07-21 | 2024-04-24 | 이뮤노젠 아이엔씨 | 세포독성 벤조다이아제핀 유도체의 제조 방법 |
| CN118099069A (zh) | 2016-03-22 | 2024-05-28 | Ev 集团 E·索尔纳有限责任公司 | 用于衬底的接合的装置和方法 |
| KR102617264B1 (ko) | 2016-10-19 | 2023-12-29 | 인벤라 인코포레이티드 | 항체 구조물 |
| JP7681879B2 (ja) | 2016-12-22 | 2025-05-23 | ウニヴェルシタ・デリ・ストゥディ・マニャ・グレチア・カタンツァーロ | Ｃｄ４３の固有のシアログリコシル化がん関連エピトープを標的化するモノクローナル抗体 |
| KR102480594B1 (ko) * | 2017-01-25 | 2022-12-26 | 이뮤노젠 아이엔씨 | 세포독성 벤조디아제핀 유도체를 제조하는 방법 |
| CA3102349A1 (en) | 2018-06-05 | 2019-12-12 | King's College London | Btnl3/8 targeting constructs for delivery of payloads to the gastrointestinal system |
| KR20210099010A (ko) * | 2018-11-12 | 2021-08-11 | 이뮤노젠 아이엔씨 | 세포독성 벤조디아제핀 유도체의 제조 방법 |
| AU2019379104A1 (en) | 2018-11-12 | 2021-06-03 | Immunogen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| CN113661172A (zh) * | 2019-03-29 | 2021-11-16 | 伊缪诺金公司 | 用于抑制异常细胞生长或治疗增生性疾病的细胞毒性双苯并二氮杂䓬衍生物及其与细胞结合剂的缀合物 |
| US20250367307A1 (en) | 2022-06-30 | 2025-12-04 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
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| US3860600A (en) | 1972-07-10 | 1975-01-14 | Sterling Drug Inc | Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines |
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2016
- 2016-07-21 KR KR1020187005041A patent/KR102660070B1/ko active Active
- 2016-07-21 US US15/216,512 patent/US9873708B2/en active Active
- 2016-07-21 EP EP20181645.1A patent/EP3778602B1/en active Active
- 2016-07-21 KR KR1020187003181A patent/KR102659706B1/ko active Active
- 2016-07-21 IL IL305989A patent/IL305989A/en unknown
- 2016-07-21 HU HUE16745598A patent/HUE051541T2/hu unknown
- 2016-07-21 WO PCT/US2016/043414 patent/WO2017015502A1/en not_active Ceased
- 2016-07-21 PL PL16745961T patent/PL3325483T3/pl unknown
- 2016-07-21 JP JP2018502785A patent/JP6858745B2/ja not_active Expired - Fee Related
- 2016-07-21 KR KR1020187005040A patent/KR20180038460A/ko not_active Withdrawn
- 2016-07-21 CN CN201680053120.5A patent/CN108055844A/zh active Pending
- 2016-07-21 ES ES16745598T patent/ES2820358T3/es active Active
- 2016-07-21 IL IL283355A patent/IL283355B/en unknown
- 2016-07-21 EP EP23183947.3A patent/EP4286387A3/en not_active Withdrawn
- 2016-07-21 JP JP2018502800A patent/JP2018522018A/ja not_active Withdrawn
- 2016-07-21 SI SI201630578T patent/SI3325483T1/sl unknown
- 2016-07-21 LT LTEP16745961.9T patent/LT3325483T/lt unknown
- 2016-07-21 RU RU2018105752A patent/RU2018105752A/ru not_active Application Discontinuation
- 2016-07-21 EP EP16745598.9A patent/EP3325482B1/en active Active
- 2016-07-21 CA CA2991326A patent/CA2991326A1/en not_active Abandoned
- 2016-07-21 DK DK16745961.9T patent/DK3325483T3/da active
- 2016-07-21 SG SG10202009354SA patent/SG10202009354SA/en unknown
- 2016-07-21 IL IL286788A patent/IL286788B2/en unknown
- 2016-07-21 ES ES20181645T patent/ES2959741T3/es active Active
- 2016-07-21 CA CA2991305A patent/CA2991305C/en active Active
- 2016-07-21 PL PL16745598T patent/PL3325482T3/pl unknown
- 2016-07-21 WO PCT/US2016/043402 patent/WO2017015495A1/en not_active Ceased
- 2016-07-21 PT PT167455989T patent/PT3325482T/pt unknown
- 2016-07-21 RS RS20201132A patent/RS60840B1/sr unknown
- 2016-07-21 AU AU2016297607A patent/AU2016297607A1/en not_active Abandoned
- 2016-07-21 HK HK18111602.7A patent/HK1252322A1/zh unknown
- 2016-07-21 CN CN201680053093.1A patent/CN108026103B/zh not_active Expired - Fee Related
- 2016-07-21 CN CN201680051138.1A patent/CN108290895B/zh not_active Expired - Fee Related
- 2016-07-21 ES ES19200626T patent/ES2933376T3/es active Active
- 2016-07-21 HR HRP20201479TT patent/HRP20201479T1/hr unknown
- 2016-07-21 EP EP22195446.4A patent/EP4163284A1/en not_active Withdrawn
- 2016-07-21 US US15/216,517 patent/US9890179B2/en not_active Expired - Fee Related
- 2016-07-21 RU RU2018105609A patent/RU2746322C2/ru active
- 2016-07-21 DK DK16745598.9T patent/DK3325482T3/da active
- 2016-07-21 LT LTEP16745598.9T patent/LT3325482T/lt unknown
- 2016-07-21 WO PCT/US2016/043406 patent/WO2017015496A1/en not_active Ceased
- 2016-07-21 KR KR1020247012816A patent/KR20240055894A/ko not_active Withdrawn
- 2016-07-21 PT PT167459619T patent/PT3325483T/pt unknown
- 2016-07-21 RS RS20191647A patent/RS59806B1/sr unknown
- 2016-07-21 CA CA3227588A patent/CA3227588A1/en active Pending
- 2016-07-21 SM SM20200004T patent/SMT202000004T1/it unknown
- 2016-07-21 CN CN202110366892.7A patent/CN113087763A/zh active Pending
- 2016-07-21 EP EP16748205.8A patent/EP3325485B1/en active Active
- 2016-07-21 EP EP16745961.9A patent/EP3325483B1/en active Active
- 2016-07-21 SG SG10202106529XA patent/SG10202106529XA/en unknown
- 2016-07-21 AU AU2016297608A patent/AU2016297608B2/en not_active Ceased
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