JP2018522018A5 - - Google Patents
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- JP2018522018A5 JP2018522018A5 JP2018502800A JP2018502800A JP2018522018A5 JP 2018522018 A5 JP2018522018 A5 JP 2018522018A5 JP 2018502800 A JP2018502800 A JP 2018502800A JP 2018502800 A JP2018502800 A JP 2018502800A JP 2018522018 A5 JP2018522018 A5 JP 2018522018A5
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- JP
- Japan
- Prior art keywords
- formula
- compound
- salt
- reacted
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562195023P | 2015-07-21 | 2015-07-21 | |
| US62/195,023 | 2015-07-21 | ||
| US201662327973P | 2016-04-26 | 2016-04-26 | |
| US62/327,973 | 2016-04-26 | ||
| PCT/US2016/043402 WO2017015495A1 (en) | 2015-07-21 | 2016-07-21 | Methods of preparing cytotoxic benzodiazepine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018522018A JP2018522018A (ja) | 2018-08-09 |
| JP2018522018A5 true JP2018522018A5 (enExample) | 2019-08-29 |
Family
ID=56557925
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502791A Expired - Fee Related JP6787995B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2018502800A Withdrawn JP2018522018A (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2018502785A Expired - Fee Related JP6858745B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2020180147A Expired - Fee Related JP6995178B2 (ja) | 2015-07-21 | 2020-10-28 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021049502A Active JP7337114B2 (ja) | 2015-07-21 | 2021-03-24 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021202215A Active JP7334228B2 (ja) | 2015-07-21 | 2021-12-14 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023132536A Withdrawn JP2023162264A (ja) | 2015-07-21 | 2023-08-16 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023134420A Withdrawn JP2023166434A (ja) | 2015-07-21 | 2023-08-22 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502791A Expired - Fee Related JP6787995B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502785A Expired - Fee Related JP6858745B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2020180147A Expired - Fee Related JP6995178B2 (ja) | 2015-07-21 | 2020-10-28 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021049502A Active JP7337114B2 (ja) | 2015-07-21 | 2021-03-24 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021202215A Active JP7334228B2 (ja) | 2015-07-21 | 2021-12-14 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023132536A Withdrawn JP2023162264A (ja) | 2015-07-21 | 2023-08-16 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023134420A Withdrawn JP2023166434A (ja) | 2015-07-21 | 2023-08-22 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (11) | US9890179B2 (enExample) |
| EP (7) | EP4163284A1 (enExample) |
| JP (8) | JP6787995B2 (enExample) |
| KR (5) | KR102660070B1 (enExample) |
| CN (5) | CN113087763A (enExample) |
| AU (7) | AU2016297607A1 (enExample) |
| CA (4) | CA2992082A1 (enExample) |
| CY (2) | CY1122553T1 (enExample) |
| DK (2) | DK3325483T3 (enExample) |
| ES (4) | ES2820358T3 (enExample) |
| HK (1) | HK1252322A1 (enExample) |
| HR (1) | HRP20201479T1 (enExample) |
| HU (1) | HUE051541T2 (enExample) |
| IL (10) | IL294651B2 (enExample) |
| LT (2) | LT3325482T (enExample) |
| PL (2) | PL3325483T3 (enExample) |
| PT (2) | PT3325483T (enExample) |
| RS (2) | RS59806B1 (enExample) |
| RU (3) | RU2727151C2 (enExample) |
| SG (2) | SG10202106529XA (enExample) |
| SI (2) | SI3325482T1 (enExample) |
| SM (2) | SMT202000506T1 (enExample) |
| WO (3) | WO2017015502A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL294651B2 (en) * | 2015-07-21 | 2024-02-01 | Immunogen Inc | Methods for the preparation of cytotoxic benzodiazepine compounds |
| CN118098938A (zh) | 2016-03-22 | 2024-05-28 | Ev 集团 E·索尔纳有限责任公司 | 用于衬底的接合的装置和方法 |
| WO2018075692A2 (en) | 2016-10-19 | 2018-04-26 | Invenra Inc. | Antibody constructs |
| EP3559039A1 (en) | 2016-12-22 | 2019-10-30 | Università Degli Studi Magna Graecia Catanzaro | A monoclonal antibody targeting a unique sialoglycosilated cancer-associated epitope of cd43 |
| RU2762891C2 (ru) | 2017-01-25 | 2021-12-23 | Иммуноджен, Инк. | Способы получения цитотоксических производных бензодиазепина |
| CN120795120A (zh) | 2018-06-05 | 2025-10-17 | 伦敦大学国王学院 | 向胃肠系统递送酬载的btnl3/8导引构建体 |
| EP3880656B1 (en) * | 2018-11-12 | 2024-03-20 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| EP3880681B1 (en) * | 2018-11-12 | 2024-03-13 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| KR20220010481A (ko) * | 2019-03-29 | 2022-01-25 | 이뮤노젠 아이엔씨 | 비정상 세포 성장의 억제 또는 증식성 질환의 치료를 위한 세포독성 비스-벤조디아제핀 유도체 및 세포결합제와 이의 접합체 |
| CN119486758A (zh) | 2022-06-30 | 2025-02-18 | 东丽株式会社 | 癌的治疗和/或预防用药物组合物 |
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| US3860600A (en) | 1972-07-10 | 1975-01-14 | Sterling Drug Inc | Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines |
| US4678784A (en) | 1984-04-11 | 1987-07-07 | Mcneilab, Inc. | Method for the treatment of LHRH diseases and conditions |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
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| CA2076465C (en) | 1992-03-25 | 2002-11-26 | Ravi V. J. Chari | Cell binding agent conjugates of analogues and derivatives of cc-1065 |
| ES2244210T3 (es) | 1998-08-27 | 2005-12-01 | Spirogen Limited | Pirrolobenzodiazepinas. |
| GB9818731D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Compounds |
| DE60032633T2 (de) | 1999-11-24 | 2007-10-04 | Immunogen Inc., Cambridge | Zytotoxische mittel, die taxane enthalten und ihre therapeutische anwendung |
| US6548042B2 (en) * | 2000-08-07 | 2003-04-15 | Arstad Erik | Bis-phosphonate compounds |
| UA75093C2 (en) * | 2000-10-06 | 2006-03-15 | Dimensional Pharm Inc | Aminopyridinyl-,aminoguanidinyl-, and alkoxyguanidinesubstituted phenylsubstituted phenylacetamides as protease inhibitors |
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| US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
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| RU2338747C2 (ru) | 2003-03-31 | 2008-11-20 | Каунсил Оф Сайентифик Энд Индастриал Рисерч | ДИМЕРЫ ПИРРОЛО [2, 1-c][1, 4] БЕНЗОДИАЗЕПИНА В КАЧЕСТВЕ ПРОТИВООПУХОЛЕВЫХ СРЕДСТВ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
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| US6884799B2 (en) | 2003-03-31 | 2005-04-26 | Council Of Scientific And Industrial Research | Non-cross-linking pyrrolo[2,1-c][1,4]benzodiazepines and process thereof |
| RU2314309C2 (ru) | 2003-03-31 | 2008-01-10 | Каунсил Оф Сайентифик Энд Индастриал Рисерч | Пирроло [2.1-c][1.4] бензодиазепины, способ их получения и фармацевтическая композиция на их основе |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
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| GB0404578D0 (en) | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
| PT2270010E (pt) * | 2004-03-01 | 2012-03-12 | Spirogen Ltd | Derivados de 11-hidroxi-5h-pirrolo[2,1-c][1,4]benzodiazepin- 5-ona como intermediários chave para a preparação de pirrolobenzodiazepinas substituídas em c2 |
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| IL294651B2 (en) * | 2015-07-21 | 2024-02-01 | Immunogen Inc | Methods for the preparation of cytotoxic benzodiazepine compounds |
| PT3380525T (pt) * | 2015-11-25 | 2024-02-05 | Immunogen Inc | Formulações farmacêuticas e métodos que as utilizam |
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2016
- 2016-07-21 IL IL294651A patent/IL294651B2/en unknown
- 2016-07-21 RS RS20191647A patent/RS59806B1/sr unknown
- 2016-07-21 IL IL283355A patent/IL283355B/en unknown
- 2016-07-21 ES ES16745598T patent/ES2820358T3/es active Active
- 2016-07-21 CN CN202110366892.7A patent/CN113087763A/zh active Pending
- 2016-07-21 KR KR1020187005041A patent/KR102660070B1/ko active Active
- 2016-07-21 CA CA2992082A patent/CA2992082A1/en active Pending
- 2016-07-21 CN CN201680051138.1A patent/CN108290895B/zh not_active Expired - Fee Related
- 2016-07-21 SG SG10202106529XA patent/SG10202106529XA/en unknown
- 2016-07-21 IL IL305989A patent/IL305989A/en unknown
- 2016-07-21 KR KR1020247012991A patent/KR20240055903A/ko not_active Withdrawn
- 2016-07-21 US US15/216,517 patent/US9890179B2/en not_active Expired - Fee Related
- 2016-07-21 JP JP2018502791A patent/JP6787995B2/ja not_active Expired - Fee Related
- 2016-07-21 SM SM20200506T patent/SMT202000506T1/it unknown
- 2016-07-21 EP EP22195446.4A patent/EP4163284A1/en not_active Withdrawn
- 2016-07-21 US US15/216,548 patent/US10081640B2/en active Active
- 2016-07-21 EP EP16748205.8A patent/EP3325485B1/en active Active
- 2016-07-21 PL PL16745961T patent/PL3325483T3/pl unknown
- 2016-07-21 PT PT167459619T patent/PT3325483T/pt unknown
- 2016-07-21 DK DK16745961.9T patent/DK3325483T3/da active
- 2016-07-21 JP JP2018502800A patent/JP2018522018A/ja not_active Withdrawn
- 2016-07-21 CN CN201680053093.1A patent/CN108026103B/zh not_active Expired - Fee Related
- 2016-07-21 HR HRP20201479TT patent/HRP20201479T1/hr unknown
- 2016-07-21 HU HUE16745598A patent/HUE051541T2/hu unknown
- 2016-07-21 ES ES19200626T patent/ES2933376T3/es active Active
- 2016-07-21 EP EP16745961.9A patent/EP3325483B1/en active Active
- 2016-07-21 WO PCT/US2016/043414 patent/WO2017015502A1/en not_active Ceased
- 2016-07-21 CN CN202110219412.4A patent/CN113004288A/zh active Pending
- 2016-07-21 WO PCT/US2016/043406 patent/WO2017015496A1/en not_active Ceased
- 2016-07-21 ES ES16745961T patent/ES2764548T3/es active Active
- 2016-07-21 LT LTEP16745598.9T patent/LT3325482T/lt unknown
- 2016-07-21 IL IL286788A patent/IL286788B2/en unknown
- 2016-07-21 IL IL305279A patent/IL305279A/en unknown
- 2016-07-21 AU AU2016297607A patent/AU2016297607A1/en not_active Abandoned
- 2016-07-21 HK HK18111602.7A patent/HK1252322A1/zh unknown
- 2016-07-21 PT PT167455989T patent/PT3325482T/pt unknown
- 2016-07-21 AU AU2016297087A patent/AU2016297087B2/en not_active Ceased
- 2016-07-21 PL PL16745598T patent/PL3325482T3/pl unknown
- 2016-07-21 KR KR1020247012816A patent/KR20240055894A/ko not_active Withdrawn
- 2016-07-21 SM SM20200004T patent/SMT202000004T1/it unknown
- 2016-07-21 EP EP19200626.0A patent/EP3653628B1/en active Active
- 2016-07-21 EP EP20181645.1A patent/EP3778602B1/en active Active
- 2016-07-21 CA CA3227588A patent/CA3227588A1/en active Pending
- 2016-07-21 RU RU2018105756A patent/RU2727151C2/ru active
- 2016-07-21 EP EP16745598.9A patent/EP3325482B1/en active Active
- 2016-07-21 CA CA2991326A patent/CA2991326A1/en not_active Abandoned
- 2016-07-21 LT LTEP16745961.9T patent/LT3325483T/lt unknown
- 2016-07-21 SI SI201630923T patent/SI3325482T1/sl unknown
- 2016-07-21 KR KR1020187003181A patent/KR102659706B1/ko active Active
- 2016-07-21 EP EP23183947.3A patent/EP4286387A3/en not_active Withdrawn
- 2016-07-21 SG SG10202009354SA patent/SG10202009354SA/en unknown
- 2016-07-21 KR KR1020187005040A patent/KR20180038460A/ko not_active Withdrawn
- 2016-07-21 WO PCT/US2016/043402 patent/WO2017015495A1/en not_active Ceased
- 2016-07-21 CA CA2991305A patent/CA2991305C/en active Active
- 2016-07-21 CN CN201680053120.5A patent/CN108055844A/zh active Pending
- 2016-07-21 JP JP2018502785A patent/JP6858745B2/ja not_active Expired - Fee Related
- 2016-07-21 AU AU2016297608A patent/AU2016297608B2/en not_active Ceased
- 2016-07-21 RU RU2018105752A patent/RU2018105752A/ru not_active Application Discontinuation
- 2016-07-21 SI SI201630578T patent/SI3325483T1/sl unknown
- 2016-07-21 ES ES20181645T patent/ES2959741T3/es active Active
- 2016-07-21 RU RU2018105609A patent/RU2746322C2/ru active
- 2016-07-21 US US15/216,512 patent/US9873708B2/en active Active
- 2016-07-21 DK DK16745598.9T patent/DK3325482T3/da active
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2017
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2018
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2022
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2023
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