JP2018522018A5 - - Google Patents
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- JP2018522018A5 JP2018522018A5 JP2018502800A JP2018502800A JP2018522018A5 JP 2018522018 A5 JP2018522018 A5 JP 2018522018A5 JP 2018502800 A JP2018502800 A JP 2018502800A JP 2018502800 A JP2018502800 A JP 2018502800A JP 2018522018 A5 JP2018522018 A5 JP 2018522018A5
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- JP
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- Prior art keywords
- formula
- compound
- salt
- reacted
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562195023P | 2015-07-21 | 2015-07-21 | |
| US62/195,023 | 2015-07-21 | ||
| US201662327973P | 2016-04-26 | 2016-04-26 | |
| US62/327,973 | 2016-04-26 | ||
| PCT/US2016/043402 WO2017015495A1 (en) | 2015-07-21 | 2016-07-21 | Methods of preparing cytotoxic benzodiazepine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018522018A JP2018522018A (ja) | 2018-08-09 |
| JP2018522018A5 true JP2018522018A5 (enExample) | 2019-08-29 |
Family
ID=56557925
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502800A Withdrawn JP2018522018A (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2018502785A Expired - Fee Related JP6858745B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2018502791A Expired - Fee Related JP6787995B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2020180147A Expired - Fee Related JP6995178B2 (ja) | 2015-07-21 | 2020-10-28 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021049502A Active JP7337114B2 (ja) | 2015-07-21 | 2021-03-24 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021202215A Active JP7334228B2 (ja) | 2015-07-21 | 2021-12-14 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023132536A Withdrawn JP2023162264A (ja) | 2015-07-21 | 2023-08-16 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023134420A Withdrawn JP2023166434A (ja) | 2015-07-21 | 2023-08-22 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502785A Expired - Fee Related JP6858745B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2018502791A Expired - Fee Related JP6787995B2 (ja) | 2015-07-21 | 2016-07-21 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2020180147A Expired - Fee Related JP6995178B2 (ja) | 2015-07-21 | 2020-10-28 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021049502A Active JP7337114B2 (ja) | 2015-07-21 | 2021-03-24 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2021202215A Active JP7334228B2 (ja) | 2015-07-21 | 2021-12-14 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023132536A Withdrawn JP2023162264A (ja) | 2015-07-21 | 2023-08-16 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
| JP2023134420A Withdrawn JP2023166434A (ja) | 2015-07-21 | 2023-08-22 | 細胞毒性ベンゾジアゼピン誘導体の調製方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (11) | US9873708B2 (enExample) |
| EP (7) | EP3653628B1 (enExample) |
| JP (8) | JP2018522018A (enExample) |
| KR (5) | KR20240055903A (enExample) |
| CN (5) | CN108055844A (enExample) |
| AU (7) | AU2016297608B2 (enExample) |
| CA (4) | CA2992082A1 (enExample) |
| CY (2) | CY1122553T1 (enExample) |
| DK (2) | DK3325482T3 (enExample) |
| ES (4) | ES2820358T3 (enExample) |
| HK (1) | HK1252322A1 (enExample) |
| HR (1) | HRP20201479T1 (enExample) |
| HU (1) | HUE051541T2 (enExample) |
| IL (10) | IL283355B (enExample) |
| LT (2) | LT3325483T (enExample) |
| PL (2) | PL3325482T3 (enExample) |
| PT (2) | PT3325482T (enExample) |
| RS (2) | RS59806B1 (enExample) |
| RU (3) | RU2018105752A (enExample) |
| SG (2) | SG10202009354SA (enExample) |
| SI (2) | SI3325482T1 (enExample) |
| SM (2) | SMT202000506T1 (enExample) |
| WO (3) | WO2017015495A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL283355B (en) | 2015-07-21 | 2022-08-01 | Immunogen Inc | Methods for the preparation of cytotoxic benzodiazepine compounds |
| CN118099069A (zh) | 2016-03-22 | 2024-05-28 | Ev 集团 E·索尔纳有限责任公司 | 用于衬底的接合的装置和方法 |
| WO2018075692A2 (en) | 2016-10-19 | 2018-04-26 | Invenra Inc. | Antibody constructs |
| KR102312222B1 (ko) | 2016-12-22 | 2021-10-12 | 우니베르시따 델리 스투디 만냐 그레챠 카탄차로 | Ｃｄ43의 독특한 시알로글리코실화된 암-연관 에피토프를 표적으로 하는 모노클로날 항체 |
| CN116554262A (zh) | 2017-01-25 | 2023-08-08 | 伊缪诺金公司 | 制备细胞毒性苯二氮䓬衍生物的方法 |
| US12152064B2 (en) | 2018-06-05 | 2024-11-26 | King's College London and GammaDelta Therapeutics Limited | BTNL3/8 targeting constructs for delivery of payloads |
| AU2019379104A1 (en) * | 2018-11-12 | 2021-06-03 | Immunogen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| US10913713B2 (en) * | 2018-11-12 | 2021-02-09 | Immunogen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| EP3947395A1 (en) * | 2019-03-29 | 2022-02-09 | ImmunoGen, Inc. | Cytotoxic bis-benzodiazepine derivatives and conjugates thereof with cell-binding agents for inhibiting abnormal cell growth or for treating proliferative diseases |
| AU2023298568A1 (en) | 2022-06-30 | 2025-01-09 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
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| US3860600A (en) | 1972-07-10 | 1975-01-14 | Sterling Drug Inc | Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines |
| US4678784A (en) | 1984-04-11 | 1987-07-07 | Mcneilab, Inc. | Method for the treatment of LHRH diseases and conditions |
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| CA2076465C (en) | 1992-03-25 | 2002-11-26 | Ravi V. J. Chari | Cell binding agent conjugates of analogues and derivatives of cc-1065 |
| DE69907977T2 (de) | 1998-08-27 | 2004-07-22 | Spirogen Ltd., Ryde | Pyrrolobenzodiazepine |
| GB9818731D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Compounds |
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| RU2314309C2 (ru) | 2003-03-31 | 2008-01-10 | Каунсил Оф Сайентифик Энд Индастриал Рисерч | Пирроло [2.1-c][1.4] бензодиазепины, способ их получения и фармацевтическая композиция на их основе |
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2016
- 2016-07-21 IL IL283355A patent/IL283355B/en unknown
- 2016-07-21 EP EP19200626.0A patent/EP3653628B1/en active Active
- 2016-07-21 AU AU2016297608A patent/AU2016297608B2/en not_active Ceased
- 2016-07-21 HR HRP20201479TT patent/HRP20201479T1/hr unknown
- 2016-07-21 KR KR1020247012991A patent/KR20240055903A/ko not_active Withdrawn
- 2016-07-21 KR KR1020187005041A patent/KR102660070B1/ko active Active
- 2016-07-21 PT PT167455989T patent/PT3325482T/pt unknown
- 2016-07-21 SG SG10202009354SA patent/SG10202009354SA/en unknown
- 2016-07-21 AU AU2016297607A patent/AU2016297607A1/en not_active Abandoned
- 2016-07-21 SI SI201630923T patent/SI3325482T1/sl unknown
- 2016-07-21 EP EP20181645.1A patent/EP3778602B1/en active Active
- 2016-07-21 SG SG10202106529XA patent/SG10202106529XA/en unknown
- 2016-07-21 EP EP16748205.8A patent/EP3325485B1/en active Active
- 2016-07-21 CN CN201680053120.5A patent/CN108055844A/zh active Pending
- 2016-07-21 JP JP2018502800A patent/JP2018522018A/ja not_active Withdrawn
- 2016-07-21 EP EP22195446.4A patent/EP4163284A1/en not_active Withdrawn
- 2016-07-21 PT PT167459619T patent/PT3325483T/pt unknown
- 2016-07-21 RS RS20191647A patent/RS59806B1/sr unknown
- 2016-07-21 US US15/216,512 patent/US9873708B2/en active Active
- 2016-07-21 DK DK16745598.9T patent/DK3325482T3/da active
- 2016-07-21 KR KR1020187003181A patent/KR102659706B1/ko active Active
- 2016-07-21 RS RS20201132A patent/RS60840B1/sr unknown
- 2016-07-21 PL PL16745598T patent/PL3325482T3/pl unknown
- 2016-07-21 CN CN201680051138.1A patent/CN108290895B/zh not_active Expired - Fee Related
- 2016-07-21 JP JP2018502785A patent/JP6858745B2/ja not_active Expired - Fee Related
- 2016-07-21 ES ES16745598T patent/ES2820358T3/es active Active
- 2016-07-21 KR KR1020187005040A patent/KR20180038460A/ko not_active Withdrawn
- 2016-07-21 LT LTEP16745961.9T patent/LT3325483T/lt unknown
- 2016-07-21 ES ES20181645T patent/ES2959741T3/es active Active
- 2016-07-21 CN CN202110219412.4A patent/CN113004288A/zh active Pending
- 2016-07-21 KR KR1020247012816A patent/KR20240055894A/ko not_active Withdrawn
- 2016-07-21 WO PCT/US2016/043402 patent/WO2017015495A1/en not_active Ceased
- 2016-07-21 ES ES16745961T patent/ES2764548T3/es active Active
- 2016-07-21 JP JP2018502791A patent/JP6787995B2/ja not_active Expired - Fee Related
- 2016-07-21 CA CA2992082A patent/CA2992082A1/en active Pending
- 2016-07-21 HK HK18111602.7A patent/HK1252322A1/zh unknown
- 2016-07-21 IL IL286788A patent/IL286788B2/en unknown
- 2016-07-21 SM SM20200506T patent/SMT202000506T1/it unknown
- 2016-07-21 IL IL305279A patent/IL305279A/en unknown
- 2016-07-21 US US15/216,548 patent/US10081640B2/en active Active
- 2016-07-21 SI SI201630578T patent/SI3325483T1/sl unknown
- 2016-07-21 RU RU2018105752A patent/RU2018105752A/ru not_active Application Discontinuation
- 2016-07-21 CA CA2991326A patent/CA2991326A1/en not_active Abandoned
- 2016-07-21 EP EP16745598.9A patent/EP3325482B1/en active Active
- 2016-07-21 CA CA3227588A patent/CA3227588A1/en active Pending
- 2016-07-21 SM SM20200004T patent/SMT202000004T1/it unknown
- 2016-07-21 LT LTEP16745598.9T patent/LT3325482T/lt unknown
- 2016-07-21 IL IL305989A patent/IL305989A/en unknown
- 2016-07-21 WO PCT/US2016/043414 patent/WO2017015502A1/en not_active Ceased
- 2016-07-21 CN CN201680053093.1A patent/CN108026103B/zh not_active Expired - Fee Related
- 2016-07-21 ES ES19200626T patent/ES2933376T3/es active Active
- 2016-07-21 RU RU2018105756A patent/RU2727151C2/ru active
- 2016-07-21 DK DK16745961.9T patent/DK3325483T3/da active
- 2016-07-21 CN CN202110366892.7A patent/CN113087763A/zh active Pending
- 2016-07-21 EP EP23183947.3A patent/EP4286387A3/en not_active Withdrawn
- 2016-07-21 IL IL294651A patent/IL294651B2/en unknown
- 2016-07-21 EP EP16745961.9A patent/EP3325483B1/en active Active
- 2016-07-21 WO PCT/US2016/043406 patent/WO2017015496A1/en not_active Ceased
- 2016-07-21 AU AU2016297087A patent/AU2016297087B2/en not_active Ceased
- 2016-07-21 RU RU2018105609A patent/RU2746322C2/ru active
- 2016-07-21 CA CA2991305A patent/CA2991305C/en active Active
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2017
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2018
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2019
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2020
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2021
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2022
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2023
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