ATE543826T1 - Als selektive antitumormittel geeignete pyrroloä2,1-cüä1,4übenzodiazepinglycosid-prodru s - Google Patents

Als selektive antitumormittel geeignete pyrroloä2,1-cüä1,4übenzodiazepinglycosid-prodru s

Info

Publication number
ATE543826T1
ATE543826T1 AT07827604T AT07827604T ATE543826T1 AT E543826 T1 ATE543826 T1 AT E543826T1 AT 07827604 T AT07827604 T AT 07827604T AT 07827604 T AT07827604 T AT 07827604T AT E543826 T1 ATE543826 T1 AT E543826T1
Authority
AT
Austria
Prior art keywords
glycoside
galactosidase
coli
prodrugs
pyrroloä2
Prior art date
Application number
AT07827604T
Other languages
English (en)
Inventor
Ahmed Kamal
Tekumalla Venkatesh
Original Assignee
Council Scient Ind Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council Scient Ind Res filed Critical Council Scient Ind Res
Application granted granted Critical
Publication of ATE543826T1 publication Critical patent/ATE543826T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT07827604T 2007-08-01 2007-10-26 Als selektive antitumormittel geeignete pyrroloä2,1-cüä1,4übenzodiazepinglycosid-prodru s ATE543826T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1626DE2007 2007-08-01
PCT/IN2007/000510 WO2009016647A1 (en) 2007-08-01 2007-10-26 Pyrrolo [2,1-c][1, 4] benzodiazepine-glycoside prodrugs useful as a selective anti tumor agent

Publications (1)

Publication Number Publication Date
ATE543826T1 true ATE543826T1 (de) 2012-02-15

Family

ID=39149123

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07827604T ATE543826T1 (de) 2007-08-01 2007-10-26 Als selektive antitumormittel geeignete pyrroloä2,1-cüä1,4übenzodiazepinglycosid-prodru s

Country Status (5)

Country Link
US (1) US7754694B2 (de)
EP (1) EP2188297B1 (de)
JP (1) JP5404624B2 (de)
AT (1) ATE543826T1 (de)
WO (1) WO2009016647A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8633028B2 (en) * 2003-07-02 2014-01-21 Musc Foundation For Research Development dsRNA induced specific and non-specific immunity in crustaceans and other invertebrates and biodelivery vehicles for use therein
FR2920877B1 (fr) * 2007-09-10 2010-01-22 Commissariat Energie Atomique Substrats fluorescents saccharidiques, leur procede de procede de preparation et leurs utisations.
SG173152A1 (en) 2009-02-05 2011-08-29 Immunogen Inc Novel benzodiazepine derivatives
KR20190089048A (ko) 2011-02-15 2019-07-29 이뮤노젠 아이엔씨 컨쥬게이트의 제조방법
WO2016001485A1 (en) 2014-06-30 2016-01-07 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
KR102660070B1 (ko) 2015-07-21 2024-04-24 이뮤노젠 아이엔씨 세포독성 벤조다이아제핀 유도체의 제조 방법
EP3380126A4 (de) 2015-11-25 2019-07-24 LegoChem Biosciences, Inc. Antikörper-wirkstoff-konjugate mit verzweigten linkern und damit verbundene verfahren
CA3006242A1 (en) 2015-11-25 2017-06-01 Legochem Biosciences, Inc. Conjugates comprising self-immolative groups and methods related thereto
CA3006247A1 (en) 2015-11-25 2017-06-01 Legochem Biosciences, Inc. Conjugates comprising peptide groups and methods related thereto
GB201617466D0 (en) * 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
WO2018182341A1 (ko) * 2017-03-29 2018-10-04 주식회사 레고켐 바이오사이언스 피롤로벤조디아제핀 이량체 전구체 및 이의 리간드-링커 접합체 화합물
AU2018246806B2 (en) 2017-03-29 2022-05-12 Ligachem Biosciences Inc. Pyrrolobenzodiazepine dimer precursor and ligand-linker conjugate compound thereof
SI3612537T1 (sl) * 2017-04-18 2022-10-28 Medimmune Limited Konjugati pirolobenzodiazepina
CA3099680A1 (en) 2018-05-09 2019-11-14 Legochem Biosciences, Inc. Compositions and methods related to anti-cd19 antibody drug conjugates
KR20210028544A (ko) 2019-09-04 2021-03-12 주식회사 레고켐 바이오사이언스 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도
US12576155B2 (en) 2019-09-25 2026-03-17 Peking University Senolytic and antiinflammatory prodrugs and methods of use thereof
WO2021057840A1 (en) * 2019-09-25 2021-04-01 Peking University Senolytic and antiinflammatory prodrugs and methods of use thereof
WO2021056270A1 (en) * 2019-09-25 2021-04-01 Peking University Senolytic prodrugs and methods of use thereof
WO2025214466A1 (en) * 2024-04-12 2025-10-16 BeiGene Guangzhou Biologics Manufacturing Co., Ltd. Targeted pyrrolobenzodiazapine conjugates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676058B1 (fr) * 1991-04-30 1994-02-25 Hoechst Lab Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers.
GB9205051D0 (en) * 1992-03-09 1992-04-22 Cancer Res Campaign Tech Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them
GB9818731D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Compounds
JP4718328B2 (ja) * 2003-12-31 2011-07-06 カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ Ｃ８連結したピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン−アクリドン／アクリジン・ハイブリッド
CA2579660A1 (en) * 2004-09-08 2006-03-16 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services (The) Beta-glucuronidase cleavable prodrugs of o6-alkylguanine-dna alkyltransferase inactivators

Also Published As

Publication number Publication date
JP5404624B2 (ja) 2014-02-05
WO2009016647A1 (en) 2009-02-05
EP2188297B1 (de) 2012-02-01
US7754694B2 (en) 2010-07-13
US20090036657A1 (en) 2009-02-05
EP2188297A1 (de) 2010-05-26
JP2010535195A (ja) 2010-11-18

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