DE60324607D1 - Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür - Google Patents

Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür

Info

Publication number
DE60324607D1
DE60324607D1 DE60324607T DE60324607T DE60324607D1 DE 60324607 D1 DE60324607 D1 DE 60324607D1 DE 60324607 T DE60324607 T DE 60324607T DE 60324607 T DE60324607 T DE 60324607T DE 60324607 D1 DE60324607 D1 DE 60324607D1
Authority
DE
Germany
Prior art keywords
pyrrolo
antitumphant
dimere
benzodiazepine
method therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60324607T
Other languages
English (en)
Inventor
Ahmed Kamal
Peram Surakattula Reddy
Depatla Rajasekhar Reddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Council of Scientific and Industrial Research CSIR
Original Assignee
Council of Scientific and Industrial Research CSIR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council of Scientific and Industrial Research CSIR filed Critical Council of Scientific and Industrial Research CSIR
Application granted granted Critical
Publication of DE60324607D1 publication Critical patent/DE60324607D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60324607T 2003-03-31 2003-03-31 Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür Expired - Lifetime DE60324607D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2003/001164 WO2004087716A1 (en) 2003-03-31 2003-03-31 Pyrrolo[(2,1-c)(1,4) benzodiazepines dimers as antitumour agents and process thereof

Publications (1)

Publication Number Publication Date
DE60324607D1 true DE60324607D1 (de) 2008-12-18

Family

ID=33104923

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60324607T Expired - Lifetime DE60324607D1 (de) 2003-03-31 2003-03-31 Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür

Country Status (6)

Country Link
EP (1) EP1608663B1 (de)
AT (1) ATE413407T1 (de)
AU (1) AU2003215810B2 (de)
CA (1) CA2520897C (de)
DE (1) DE60324607D1 (de)
WO (1) WO2004087716A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE527262T1 (de) * 2006-01-25 2011-10-15 Sanofi Sa Neue tomaymycin derivate enhaltende zytotoxische mittel
DE112007000079B4 (de) * 2006-02-13 2015-08-13 Council Of Scientific & Industrial Research Neuartige Bis-Pyrrolo[2,1-c][1,4]benzodiazepin-anthrachinon Konjugate und ein Verfahren zu deren Herstellung
ES2435779T3 (es) * 2007-07-19 2013-12-23 Sanofi Agentes citotóxicos que comprenden nuevos derivados de tomaimicina y su uso terapéutico
JP5657395B2 (ja) * 2008-03-05 2015-01-21 カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチＣｏｕｎｃｉｌ Ｏｆ Ｓｃｉｅｎｔｉｆｉｃ ＆ Ｉｎｄｕｓｔｒｉａｌ Ｒｅｓｅａｒｃｈ 有効性のある抗がん剤としてのキナゾリン結合ピロロ［２，１−ｃ］［１，４］ベンゾジアゼピンハイブリッド及びその作製方法
WO2009113084A1 (en) * 2008-03-11 2009-09-17 Council Of Scientific & Industrial Research C2-fluoro substituted piperazine linked pyrrolo[2,1-c][1,4] benzodiazepine dimers and a process for the preparation thereof
EP2262809A1 (de) * 2008-03-26 2010-12-22 Council Of Scientific & Industrial Research Benzophenonpiperazingebundene pyrrolo[2,1-c][1,4]benzodiazepinhybride als potentielle antikrebsmittel und verfahren zu deren herstellung
RU2545080C2 (ru) * 2009-02-05 2015-03-27 Иммьюноджен, Инк. Новые производные бензодиазепина
JP5941058B2 (ja) * 2010-12-06 2016-06-29 カウンシル・オヴ・サイエンティフィック・アンド・インダストリアル・リサーチ 潜在的抗腫瘍剤としてのピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン結合型イミダゾ［１，５−ａ］ピリジン複合体およびその調製方法
PL2675479T3 (pl) 2011-02-15 2016-09-30 Cytotoksyczne pochodne benzodiazepiny
US9504694B2 (en) 2015-03-19 2016-11-29 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
KR20180038460A (ko) 2015-07-21 2018-04-16 이뮤노젠 아이엔씨 세포독성 벤조다이아제핀 유도체의 제조 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9205051D0 (en) * 1992-03-09 1992-04-22 Cancer Res Campaign Tech Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them

Also Published As

Publication number Publication date
AU2003215810B2 (en) 2009-06-18
WO2004087716A1 (en) 2004-10-14
EP1608663B1 (de) 2008-11-05
CA2520897A1 (en) 2004-10-14
CA2520897C (en) 2010-08-24
EP1608663A1 (de) 2005-12-28
AU2003215810A1 (en) 2004-10-25
ATE413407T1 (de) 2008-11-15

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