YU61595A - Nova naftilna jedinjenja, njihovi intermedijeri farmaceutske kompozicije, i postupci za dobijanje tih jedinjenja - Google Patents
Nova naftilna jedinjenja, njihovi intermedijeri farmaceutske kompozicije, i postupci za dobijanje tih jedinjenjaInfo
- Publication number
- YU61595A YU61595A YU61595A YU61595A YU61595A YU 61595 A YU61595 A YU 61595A YU 61595 A YU61595 A YU 61595A YU 61595 A YU61595 A YU 61595A YU 61595 A YU61595 A YU 61595A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- alkyl
- compounds
- intermediates
- preparation
- compositions
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 125000001624 naphthyl group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 methyl-1-pyrrolidinyl Chemical group 0.000 abstract 4
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pyrrole Compounds (AREA)
- Electroluminescent Light Sources (AREA)
- Plural Heterocyclic Compounds (AREA)
- Silicon Polymers (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Opisana su jedinjenja formule I gde R1 predstavlja -H, -OH, -O(C1-C4alkil), -OCOC6H5, -OCO(C1-C6alkil), ili -OSO2(C4-C6alkil); R2 predstavlja -H, -OH, -O(C1-C4alkil), -OCOC6H5, -OCO(C1-C6alkil) ili -OSO2(C4-C6alkil); n predstavlja 2 ili 3; i R3 je 1-piperidinil, 1-pirolidinil, metil-1-pirolidinil, dimetil-1-pirolidinil, 4-morfolino, dimetilamino, dietilamino, ili 1-heksametilenimino; ili njihova farmaceutski prihvatljiva so. Takodje su opisani inermedijeri tih jedinjenja, farmaceutske smese sa tim jedinjenjima kao aktivnim supstancama, i postupak za dobijanje tih jedinjenja.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/309,525 US7501441B1 (en) | 1994-09-20 | 1994-09-20 | Naphthyl compounds, intermediates, processes, compositions, and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
YU61595A true YU61595A (sh) | 1998-09-18 |
Family
ID=23198583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU61595A YU61595A (sh) | 1994-09-20 | 1995-09-19 | Nova naftilna jedinjenja, njihovi intermedijeri farmaceutske kompozicije, i postupci za dobijanje tih jedinjenja |
Country Status (29)
Country | Link |
---|---|
US (6) | US7501441B1 (sh) |
EP (1) | EP0703228B1 (sh) |
JP (1) | JPH10506392A (sh) |
KR (1) | KR970705983A (sh) |
AT (1) | ATE214058T1 (sh) |
AU (1) | AU697114B2 (sh) |
BR (1) | BR9508967A (sh) |
CA (1) | CA2200449A1 (sh) |
CO (1) | CO4410318A1 (sh) |
CZ (1) | CZ291207B6 (sh) |
DE (1) | DE69525699T2 (sh) |
DK (1) | DK0703228T3 (sh) |
ES (1) | ES2173154T3 (sh) |
HU (1) | HUT77919A (sh) |
IL (1) | IL115335A (sh) |
MX (1) | MX9702154A (sh) |
MY (1) | MY132075A (sh) |
NO (1) | NO307929B1 (sh) |
NZ (1) | NZ294177A (sh) |
PE (1) | PE47496A1 (sh) |
PL (1) | PL319454A1 (sh) |
PT (1) | PT703228E (sh) |
RU (1) | RU2165924C2 (sh) |
SI (1) | SI0703228T1 (sh) |
TR (1) | TR199501135A2 (sh) |
TW (1) | TW399036B (sh) |
WO (1) | WO1996009039A1 (sh) |
YU (1) | YU61595A (sh) |
ZA (1) | ZA957857B (sh) |
Families Citing this family (67)
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US6515009B1 (en) * | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6251920B1 (en) | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
US5770609A (en) | 1993-01-28 | 1998-06-23 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
WO1994026303A1 (en) | 1993-05-13 | 1994-11-24 | Neorx Corporation | Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells |
US20030083733A1 (en) * | 1997-10-10 | 2003-05-01 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5998401A (en) * | 1995-02-28 | 1999-12-07 | Eli Lilly And Company | Naphthyl compounds, intermediates, compositions, and methods |
US6451817B1 (en) * | 1995-03-10 | 2002-09-17 | Eli Lilly And Company | Alpha-substituted-1-benzyl-napthyls |
US6391892B1 (en) * | 1995-03-10 | 2002-05-21 | Eli Lilly And Company | Naphthyl pharmaceutical compounds |
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ATE377418T1 (de) | 1995-06-07 | 2007-11-15 | Poniard Pharmaceuticals Inc | Vorbeugung und behandlung von kardiovaskulären beschwerden mit tamoxifen-analogen |
US5811421A (en) * | 1995-07-31 | 1998-09-22 | Eli Lilly And Company | Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods |
GB2312844A (en) * | 1996-05-07 | 1997-11-12 | Lilly Co Eli | A naphthyl compound for the treatment of immune-complex diseases |
CA2213814A1 (en) * | 1996-08-29 | 1998-02-28 | Henry Uhlman Bryant | Naphthalene compounds, intermediates, formulations, and methods |
US6599920B2 (en) * | 1996-08-29 | 2003-07-29 | Eli Lilly And Company | Naphthalene compounds, intermediates, formulations, and methods |
ID19392A (id) | 1996-08-29 | 1998-07-09 | Lilly Co Eli | Senyawa naftil dan bahan pertengahan serta komposisi dan metode penggunaan |
CA2214070C (en) * | 1996-08-29 | 2006-03-14 | Eli Lilly And Company | Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods |
SI0826679T1 (en) * | 1996-08-29 | 2002-04-30 | Eli Lilly And Company | Naphthyl compounds and compositions |
CA2214929A1 (en) * | 1996-09-26 | 1998-03-26 | Charles Willis Lugar, Iii | Naphthofluorene compounds, intermediates, compositions and methods |
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CA2214931A1 (en) * | 1996-09-26 | 1998-03-26 | Henry Uhlman Bryant | Tetrahydrobenzo-a-fluorene compounds and method of use |
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EP1692101B1 (en) * | 2003-03-31 | 2011-07-06 | Council of Scientific and Industrial Research | Mercapto-phenyl-naphthyl-methane derivatives and preparation thereof |
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KR20070084455A (ko) * | 2004-11-23 | 2007-08-24 | 워너-램버트 캄파니 엘엘씨 | 지질혈증 치료용 hmg co-a 환원효소 억제제로서의7-(2h-피라졸-3-일)-3,5-디히드록시-헵탄산 유도체 |
CA2599611C (en) * | 2005-02-09 | 2013-07-30 | Chiang J. Li | Meleimide derivatives, pharmaceutical compositions and methods for treatment of cancer |
US7655700B2 (en) | 2005-08-25 | 2010-02-02 | Michigan State University | Transgenic mouse model and methods for treatment of neuro muscular disease by interfering with androgen-androgen receptor interaction in skeletal muscles |
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US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
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CA2802761C (en) | 2010-06-16 | 2017-01-03 | Endorecherche, Inc. | Methods of treating or preventing estrogen-related diseases |
CA3090807A1 (en) | 2018-02-21 | 2019-08-29 | AI Therapeutics, Inc. | Combination therapy with apilimod and glutamatergic agents |
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DE4122484A1 (de) | 1991-07-06 | 1993-01-07 | Teves Gmbh Alfred | Schaltungsanordnung zur erkennung von radsensordefekten |
US5147880A (en) * | 1991-07-22 | 1992-09-15 | Eli Lilly And Company | Benzo[a]fluorene compounds |
JP3157882B2 (ja) | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
US5407955A (en) * | 1994-02-18 | 1995-04-18 | Eli Lilly And Company | Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease |
US5384332A (en) * | 1994-05-11 | 1995-01-24 | Eli Lilly And Company | Methods for inhibiting aortal smooth muscle cell proliferation and restenosis with 1,1,2-triphenylbut-1-ene derivatives |
-
1994
- 1994-09-20 US US08/309,525 patent/US7501441B1/en not_active Expired - Fee Related
-
1995
- 1995-04-21 US US08/428,924 patent/US5484797A/en not_active Expired - Fee Related
- 1995-04-21 US US08/426,542 patent/US5484795A/en not_active Expired - Fee Related
- 1995-04-21 US US08/426,318 patent/US6437137B1/en not_active Expired - Fee Related
- 1995-04-21 US US08/428,922 patent/US6410564B1/en not_active Expired - Fee Related
- 1995-04-21 US US08/426,770 patent/US5484796A/en not_active Expired - Fee Related
- 1995-09-18 CA CA002200449A patent/CA2200449A1/en not_active Abandoned
- 1995-09-18 MY MYPI95002757A patent/MY132075A/en unknown
- 1995-09-18 CO CO95042772A patent/CO4410318A1/es unknown
- 1995-09-18 ES ES95306549T patent/ES2173154T3/es not_active Expired - Lifetime
- 1995-09-18 SI SI9530587T patent/SI0703228T1/xx unknown
- 1995-09-18 PE PE1995279259A patent/PE47496A1/es not_active Application Discontinuation
- 1995-09-18 DK DK95306549T patent/DK0703228T3/da active
- 1995-09-18 IL IL11533595A patent/IL115335A/xx active IP Right Grant
- 1995-09-18 TW TW084109782A patent/TW399036B/zh not_active IP Right Cessation
- 1995-09-18 NZ NZ294177A patent/NZ294177A/xx unknown
- 1995-09-18 RU RU97106345/04A patent/RU2165924C2/ru active
- 1995-09-18 PL PL95319454A patent/PL319454A1/xx unknown
- 1995-09-18 CZ CZ1997822A patent/CZ291207B6/cs not_active IP Right Cessation
- 1995-09-18 HU HU9801473A patent/HUT77919A/hu unknown
- 1995-09-18 KR KR1019970701827A patent/KR970705983A/ko active IP Right Grant
- 1995-09-18 EP EP95306549A patent/EP0703228B1/en not_active Expired - Lifetime
- 1995-09-18 ZA ZA957857A patent/ZA957857B/xx unknown
- 1995-09-18 BR BR9508967A patent/BR9508967A/pt not_active Application Discontinuation
- 1995-09-18 DE DE69525699T patent/DE69525699T2/de not_active Expired - Fee Related
- 1995-09-18 AU AU36863/95A patent/AU697114B2/en not_active Ceased
- 1995-09-18 PT PT95306549T patent/PT703228E/pt unknown
- 1995-09-18 JP JP8511132A patent/JPH10506392A/ja not_active Withdrawn
- 1995-09-18 MX MX9702154A patent/MX9702154A/es not_active IP Right Cessation
- 1995-09-18 AT AT95306549T patent/ATE214058T1/de not_active IP Right Cessation
- 1995-09-18 WO PCT/US1995/012346 patent/WO1996009039A1/en active IP Right Grant
- 1995-09-19 TR TR95/01135A patent/TR199501135A2/xx unknown
- 1995-09-19 YU YU61595A patent/YU61595A/sh unknown
-
1997
- 1997-03-19 NO NO971278A patent/NO307929B1/no not_active IP Right Cessation
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