ATE413407T1 - Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür - Google Patents

Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür

Info

Publication number
ATE413407T1
ATE413407T1 AT03816507T AT03816507T ATE413407T1 AT E413407 T1 ATE413407 T1 AT E413407T1 AT 03816507 T AT03816507 T AT 03816507T AT 03816507 T AT03816507 T AT 03816507T AT E413407 T1 ATE413407 T1 AT E413407T1
Authority
AT
Austria
Prior art keywords
pyrrolo
tumor agents
benzodiazepine dimers
analogues
benzodiazepine
Prior art date
Application number
AT03816507T
Other languages
English (en)
Inventor
Ahmed Kamal
Peram Reddy
Depatla Reddy
Original Assignee
Council Scient Ind Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council Scient Ind Res filed Critical Council Scient Ind Res
Application granted granted Critical
Publication of ATE413407T1 publication Critical patent/ATE413407T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03816507T 2003-03-31 2003-03-31 Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür ATE413407T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2003/001164 WO2004087716A1 (en) 2003-03-31 2003-03-31 Pyrrolo[(2,1-c)(1,4) benzodiazepines dimers as antitumour agents and process thereof

Publications (1)

Publication Number Publication Date
ATE413407T1 true ATE413407T1 (de) 2008-11-15

Family

ID=33104923

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03816507T ATE413407T1 (de) 2003-03-31 2003-03-31 Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür

Country Status (6)

Country Link
EP (1) EP1608663B1 (de)
AT (1) ATE413407T1 (de)
AU (1) AU2003215810B2 (de)
CA (1) CA2520897C (de)
DE (1) DE60324607D1 (de)
WO (1) WO2004087716A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1813614T3 (da) 2006-01-25 2012-01-23 Sanofi Sa Cytotoksiske midler, der omfatter nye tomaymycinderivater
JP2009526778A (ja) * 2006-02-13 2009-07-23 カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ 抗腫瘍剤としてのビス−ピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン−アントラキノン抱合体およびその製造方法
SI2019104T1 (sl) * 2007-07-19 2013-12-31 Sanofi Citotoksična sredstva, ki obsegajo nove tomaimicinske derivate, in njihova terapevtska uporaba
EP2265613B1 (de) * 2008-03-05 2013-07-24 Council Of Scientific & Industrial Research Chinazolingebundene pyrrolo[2,1-c][1, 4]benzodiazepinhybride als potentielle antikrebsmittel und verfahren zu deren herstellung
EP2271647B1 (de) 2008-03-11 2012-12-05 Council Of Scientific & Industrial Research C2-fluor-substituierte piperazingebundene pyrrolo[2,1-c][1,4]benzodiazepindimere und verfahren zu deren herstellung
EP2262809A1 (de) * 2008-03-26 2010-12-22 Council Of Scientific & Industrial Research Benzophenonpiperazingebundene pyrrolo[2,1-c][1,4]benzodiazepinhybride als potentielle antikrebsmittel und verfahren zu deren herstellung
EP3100745B1 (de) * 2009-02-05 2018-04-18 Immunogen, Inc. Neuartige benzodiazepinderivate
WO2012076941A1 (en) * 2010-12-06 2012-06-14 Council Of Scientific & Industrial Research Pyrrolo[2,1-c][1,4]benzodiazepine linked imidazo[1,5-a]pyridine conjugates as potential antitumour agents and process for the preparation thereof
EP2675479B1 (de) 2011-02-15 2016-01-13 Immunogen, Inc. Zytotoxische benzodiazepin-derivate
US9504694B2 (en) 2015-03-19 2016-11-29 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
EP3653628B1 (de) 2015-07-21 2022-09-14 ImmunoGen, Inc. Verfahren zur herstellung von zytostatischen benzodiazepinderivaten

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9205051D0 (en) * 1992-03-09 1992-04-22 Cancer Res Campaign Tech Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them

Also Published As

Publication number Publication date
CA2520897A1 (en) 2004-10-14
EP1608663B1 (de) 2008-11-05
AU2003215810A1 (en) 2004-10-25
DE60324607D1 (de) 2008-12-18
CA2520897C (en) 2010-08-24
AU2003215810B2 (en) 2009-06-18
EP1608663A1 (de) 2005-12-28
WO2004087716A1 (en) 2004-10-14

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