ATE413407T1 - Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür - Google Patents

Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür

Info

Publication number
ATE413407T1
ATE413407T1 AT03816507T AT03816507T ATE413407T1 AT E413407 T1 ATE413407 T1 AT E413407T1 AT 03816507 T AT03816507 T AT 03816507T AT 03816507 T AT03816507 T AT 03816507T AT E413407 T1 ATE413407 T1 AT E413407T1
Authority
AT
Austria
Prior art keywords
pyrrolo
tumor agents
benzodiazepine dimers
analogues
benzodiazepine
Prior art date
Application number
AT03816507T
Other languages
English (en)
Inventor
Ahmed Kamal
Peram Reddy
Depatla Reddy
Original Assignee
Council Scient Ind Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council Scient Ind Res filed Critical Council Scient Ind Res
Application granted granted Critical
Publication of ATE413407T1 publication Critical patent/ATE413407T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03816507T 2003-03-31 2003-03-31 Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür ATE413407T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2003/001164 WO2004087716A1 (en) 2003-03-31 2003-03-31 Pyrrolo[(2,1-c)(1,4) benzodiazepines dimers as antitumour agents and process thereof

Publications (1)

Publication Number Publication Date
ATE413407T1 true ATE413407T1 (de) 2008-11-15

Family

ID=33104923

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03816507T ATE413407T1 (de) 2003-03-31 2003-03-31 Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür

Country Status (6)

Country Link
EP (1) EP1608663B1 (de)
AT (1) ATE413407T1 (de)
AU (1) AU2003215810B2 (de)
CA (1) CA2520897C (de)
DE (1) DE60324607D1 (de)
WO (1) WO2004087716A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE527262T1 (de) * 2006-01-25 2011-10-15 Sanofi Sa Neue tomaymycin derivate enhaltende zytotoxische mittel
JP2009526778A (ja) * 2006-02-13 2009-07-23 カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ 抗腫瘍剤としてのビス−ピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン−アントラキノン抱合体およびその製造方法
SI2019104T1 (sl) * 2007-07-19 2013-12-31 Sanofi Citotoksična sredstva, ki obsegajo nove tomaimicinske derivate, in njihova terapevtska uporaba
US8153627B2 (en) 2008-03-05 2012-04-10 Council Of Scientific & Industrial Research Quinazoline linked pyrrolo[2,1-C][1, 4]benzodiazepine hybrids as potential anticancer agents and process for the preparation thereof
EP2271647B1 (de) 2008-03-11 2012-12-05 Council Of Scientific & Industrial Research C2-fluor-substituierte piperazingebundene pyrrolo[2,1-c][1,4]benzodiazepindimere und verfahren zu deren herstellung
EP2262809A1 (de) * 2008-03-26 2010-12-22 Council Of Scientific & Industrial Research Benzophenonpiperazingebundene pyrrolo[2,1-c][1,4]benzodiazepinhybride als potentielle antikrebsmittel und verfahren zu deren herstellung
CN102365021B (zh) 2009-02-05 2015-07-15 伊缪诺金公司 新型苯并二氮杂*衍生物
EP2648757B1 (de) * 2010-12-06 2015-07-22 Council Of Scientific & Industrial Research Pyrrolo [2,1-c] [1,4] benzodiazepin-gebundene imidazo[1,5-a] pyridinkonjugate als potenzielle antitumorwirkstoffe und verfahren zu ihrer herstellung
KR20140010076A (ko) 2011-02-15 2014-01-23 이뮤노젠 아이엔씨 세포독성 벤조다이아제핀 유도체
US9504694B2 (en) 2015-03-19 2016-11-29 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
SMT202000004T1 (it) 2015-07-21 2020-03-13 Immunogen Inc Metodi di preparazione dei derivati citotossici di benzodiazepina

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9205051D0 (en) * 1992-03-09 1992-04-22 Cancer Res Campaign Tech Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them

Also Published As

Publication number Publication date
AU2003215810B2 (en) 2009-06-18
DE60324607D1 (de) 2008-12-18
EP1608663A1 (de) 2005-12-28
CA2520897C (en) 2010-08-24
AU2003215810A1 (en) 2004-10-25
CA2520897A1 (en) 2004-10-14
WO2004087716A1 (en) 2004-10-14
EP1608663B1 (de) 2008-11-05

Similar Documents

Publication Publication Date Title
MXPA05011710A (es) Derivados de pirimidina con actividad de crf.
ATE365740T1 (de) Substituierte pyrazolopyrimidine
EA200200716A1 (ru) Арилконденсированные азаполициклические соединения
BG107120A (bg) Нови бавнодействащи бетамиметици, метод за тяхното получаване и приложението им като лекарствени средства
ATE421967T1 (de) Nichtvernetzende pyrroloä2,1-cüä1, 4übenzodiazepine als potentielle antitumor- agentien und ihre herstellung
EA200500342A1 (ru) Гетероциклические замещённые пиперазины для лечения шизофрении
BR0113234A (pt) Polimorfos de um análogo de epotilona
SE0104140D0 (sv) Novel Compounds
EE200000318A (et) Uudsed ühendid
ATE410412T1 (de) Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen
DE60204452D1 (de) Pyrazolo[1,5]pyridinderivate
BG66085B1 (bg) Фенилаланинови производни
EA200300527A1 (ru) Новые способы лечения синдрома "усталых ног"
TW200519096A (en) Quinazoline analogs as receptor tyrosine kinase inhibitors
DE60324607D1 (de) Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür
ID25856A (id) Senyawa-senyawa baru
TR200002380T2 (tr) Yeni triazolo (4,5-d) pirimidin bileşikleri
SE9904129D0 (sv) Novel compounds
DE60301339D1 (de) Pyrazolopyrimidin- und pyrazolotriazinderivate und diese enthaltende pharmazeutische zubereitungen
EA200600688A1 (ru) Арилинденпиридины и арилинденпиримидины и их применение в качестве антагонистов аденозинового рецептора а2а
AP2001002188A0 (en) 5HT1 antagonists for antidepressant therapy.
EA200400806A1 (ru) Способ получения эхинокандиновых соединений
DE69911785D1 (de) Triazolo[4,5-d]pyrimidin-verbindungen
EA200400323A1 (ru) Аралкилтетрагидропиридины, их получение и содержащие их фармацевтические композиции
MXPA04005151A (es) Compuestos terapeuticos.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties