JP2019504839A5 - - Google Patents

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Publication number
JP2019504839A5
JP2019504839A5 JP2018539136A JP2018539136A JP2019504839A5 JP 2019504839 A5 JP2019504839 A5 JP 2019504839A5 JP 2018539136 A JP2018539136 A JP 2018539136A JP 2018539136 A JP2018539136 A JP 2018539136A JP 2019504839 A5 JP2019504839 A5 JP 2019504839A5
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JP
Japan
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formula
compound
aldehyde
reducing agent
salt
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JP2018539136A
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English (en)
Japanese (ja)
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JP2019504839A (ja
JP6786610B2 (ja
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Priority claimed from PCT/US2017/017501 external-priority patent/WO2017139664A1/en
Publication of JP2019504839A publication Critical patent/JP2019504839A/ja
Publication of JP2019504839A5 publication Critical patent/JP2019504839A5/ja
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Publication of JP6786610B2 publication Critical patent/JP6786610B2/ja
Expired - Fee Related legal-status Critical Current
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JP2018539136A 2016-02-12 2017-02-10 エリブリンの合成における中間体および関連する合成方法 Expired - Fee Related JP6786610B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662294538P 2016-02-12 2016-02-12
US62/294,538 2016-02-12
PCT/US2017/017501 WO2017139664A1 (en) 2016-02-12 2017-02-10 Intermediates in the synthesis of eribulin and related methods of synthesis

Publications (3)

Publication Number Publication Date
JP2019504839A JP2019504839A (ja) 2019-02-21
JP2019504839A5 true JP2019504839A5 (enExample) 2020-03-19
JP6786610B2 JP6786610B2 (ja) 2020-11-18

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ID=59563582

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JP2018539136A Expired - Fee Related JP6786610B2 (ja) 2016-02-12 2017-02-10 エリブリンの合成における中間体および関連する合成方法

Country Status (10)

Country Link
US (1) US10676481B2 (enExample)
EP (1) EP3413887B1 (enExample)
JP (1) JP6786610B2 (enExample)
KR (1) KR20180107243A (enExample)
CN (1) CN108601760A (enExample)
IL (1) IL260717B (enExample)
MX (1) MX377663B (enExample)
RU (1) RU2732575C2 (enExample)
SG (1) SG11201806133UA (enExample)
WO (1) WO2017139664A1 (enExample)

Families Citing this family (10)

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PL2522663T3 (pl) 2004-06-03 2015-08-31 Eisai R&D Man Co Ltd Produkty pośrednie do otrzymywania halichondryny B
EP2578576B9 (en) 2007-10-03 2016-09-14 Eisai R&D Management Co., Ltd. Intermediates for the synthesis of halichondrin B analogs
SG182612A1 (en) 2010-01-26 2012-08-30 Eisai R&D Man Co Ltd Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs
HUE049387T2 (hu) 2013-11-04 2020-09-28 Eisai R&D Man Co Ltd A halichondrin B analógjainak szintézisében hasznos makrociklizációs reakciók és köztitermékek
SG11201604545XA (en) 2013-12-06 2016-07-28 Eisai R&D Man Co Ltd Methods useful in the synthesis of halichondrin b analogs
KR102743950B1 (ko) 2015-05-07 2024-12-18 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤라이드의 합성에 유용한 마크로고리화 반응 및 중간체 및 기타 단편
MX390072B (es) 2016-06-30 2025-03-20 Eisai R&D Man Co Ltd Reaccion de prins e intermediarios utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos.
KR102799793B1 (ko) 2018-01-03 2025-04-25 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 화합물
CN110568121A (zh) * 2019-07-11 2019-12-13 山东省药学科学院 一种艾日布林及含艾日布林的制剂中有关物质的检测方法
KR102377262B1 (ko) 2020-05-11 2022-03-22 연성정밀화학(주) 결정성 에리불린 염

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PL2522663T3 (pl) 2004-06-03 2015-08-31 Eisai R&D Man Co Ltd Produkty pośrednie do otrzymywania halichondryny B
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JP2009510005A (ja) 2005-09-26 2009-03-12 シムライズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・ウント・コンパニー・コマンジツト・ゲゼルシヤフト 分子内プリンス反応および該反応に適する触媒
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JP5371091B2 (ja) 2009-01-23 2013-12-18 三菱レイヨン株式会社 モノスルホン酸エステルの製造方法
SG182612A1 (en) 2010-01-26 2012-08-30 Eisai R&D Man Co Ltd Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs
WO2012147900A1 (en) * 2011-04-28 2012-11-01 Eisai R&D Management Co., Ltd. Microreactor process for halichondrin b analog synthesis
AU2012344697A1 (en) 2011-11-30 2014-07-10 Alphora Research Inc. Process for preparation of (3R)-2,4-di-leaving group-3-methylbut-1-ene
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JP6511613B2 (ja) 2013-07-03 2019-05-15 サンド・アクチエンゲゼルシヤフト ハリコンドリンBの大環状C1−ケト類似体の製造のための合成方法及び該方法に有用な中間体、例えば−SO2−(p−トリル)基を含有する中間体
HUE049387T2 (hu) 2013-11-04 2020-09-28 Eisai R&D Man Co Ltd A halichondrin B analógjainak szintézisében hasznos makrociklizációs reakciók és köztitermékek
SG11201604545XA (en) 2013-12-06 2016-07-28 Eisai R&D Man Co Ltd Methods useful in the synthesis of halichondrin b analogs
WO2016038624A1 (en) 2014-09-09 2016-03-17 Cipla Limited "process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof"
KR102743950B1 (ko) 2015-05-07 2024-12-18 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤라이드의 합성에 유용한 마크로고리화 반응 및 중간체 및 기타 단편
MX390072B (es) 2016-06-30 2025-03-20 Eisai R&D Man Co Ltd Reaccion de prins e intermediarios utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos.
WO2018217894A1 (en) 2017-05-24 2018-11-29 Eisai R&D Management Co., Ltd. Fluorine-labelled halichondrin derivatives and related methods of synthesis
KR102799793B1 (ko) 2018-01-03 2025-04-25 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 화합물

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