JP2019504839A5 - - Google Patents
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- JP2019504839A5 JP2019504839A5 JP2018539136A JP2018539136A JP2019504839A5 JP 2019504839 A5 JP2019504839 A5 JP 2019504839A5 JP 2018539136 A JP2018539136 A JP 2018539136A JP 2018539136 A JP2018539136 A JP 2018539136A JP 2019504839 A5 JP2019504839 A5 JP 2019504839A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- aldehyde
- reducing agent
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662294538P | 2016-02-12 | 2016-02-12 | |
| US62/294,538 | 2016-02-12 | ||
| PCT/US2017/017501 WO2017139664A1 (en) | 2016-02-12 | 2017-02-10 | Intermediates in the synthesis of eribulin and related methods of synthesis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504839A JP2019504839A (ja) | 2019-02-21 |
| JP2019504839A5 true JP2019504839A5 (enExample) | 2020-03-19 |
| JP6786610B2 JP6786610B2 (ja) | 2020-11-18 |
Family
ID=59563582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018539136A Expired - Fee Related JP6786610B2 (ja) | 2016-02-12 | 2017-02-10 | エリブリンの合成における中間体および関連する合成方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10676481B2 (enExample) |
| EP (1) | EP3413887B1 (enExample) |
| JP (1) | JP6786610B2 (enExample) |
| KR (1) | KR20180107243A (enExample) |
| CN (1) | CN108601760A (enExample) |
| IL (1) | IL260717B (enExample) |
| MX (1) | MX377663B (enExample) |
| RU (1) | RU2732575C2 (enExample) |
| SG (1) | SG11201806133UA (enExample) |
| WO (1) | WO2017139664A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101899026B (zh) | 2004-06-03 | 2016-08-03 | 卫材R&D管理有限公司 | 用于制备软海绵素b的类似物的中间体 |
| BRPI0817909B1 (pt) | 2007-10-03 | 2022-06-21 | Eisai R&D Management Co., Ltd | Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos |
| BR112012018232B8 (pt) | 2010-01-26 | 2023-01-10 | Eisai R&D Man Co Ltd | Compostos derivados de furo [3,2-b] pirano úteis na síntese de análogos de halicondrina b e métodos de sintetização de er-80402 e de eribulina |
| HUE049387T2 (hu) | 2013-11-04 | 2020-09-28 | Eisai R&D Man Co Ltd | A halichondrin B analógjainak szintézisében hasznos makrociklizációs reakciók és köztitermékek |
| SG10201805024YA (en) | 2013-12-06 | 2018-07-30 | Eisai R&D Man Co Ltd | Methods useful in the synthesis of halichondrin b analogs |
| MX380284B (es) | 2015-05-07 | 2025-03-12 | Eisai R&D Man Co Ltd | Reacciones de macrociclización e intermediarios y otros fragmentos útiles en la síntesis de macrólidos de halicondrina. |
| SG11201811671XA (en) | 2016-06-30 | 2019-01-30 | Eisai R&D Man Co Ltd | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
| KR20250057138A (ko) | 2018-01-03 | 2025-04-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 화합물 |
| CN110568121A (zh) * | 2019-07-11 | 2019-12-13 | 山东省药学科学院 | 一种艾日布林及含艾日布林的制剂中有关物质的检测方法 |
| KR102377262B1 (ko) * | 2020-05-11 | 2022-03-22 | 연성정밀화학(주) | 결정성 에리불린 염 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU652180A1 (ru) | 1975-12-16 | 1979-03-15 | Краснодарский политехнический институт | 1(Фурил-2,)-2-(2-,, формилфурил-5,, ) этилен или его метильное производное как промежуточный продукт дл синтеза фуран-2,5-дикарбоновой кислоты и способ его получени |
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| GB9206244D0 (en) | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
| TW255880B (enExample) | 1992-09-09 | 1995-09-01 | Hoechst Ag | |
| JP2001500498A (ja) | 1996-09-06 | 2001-01-16 | イーライ・リリー・アンド・カンパニー | 触媒選択的スルホニル化法 |
| US6870058B2 (en) | 1996-12-03 | 2005-03-22 | The Trustees Of The University Of Pennsylvania | Compounds which mimic the chemical and biological properties of discodermolide |
| IL139960A0 (en) | 1998-06-17 | 2002-02-10 | Eisai Co Ltd | Macrocylic analogs and methods of their use and preparation |
| US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| DE10106647A1 (de) | 2001-02-12 | 2002-08-22 | Univ Hannover | Ratjadon-Derivate zum Hemmen des Zellwachstums |
| CN101899026B (zh) | 2004-06-03 | 2016-08-03 | 卫材R&D管理有限公司 | 用于制备软海绵素b的类似物的中间体 |
| US20060045846A1 (en) | 2004-08-30 | 2006-03-02 | Horstmann Thomas E | Reagents and methods for labeling terminal olefins |
| WO2006076100A2 (en) | 2004-12-09 | 2006-07-20 | Eisai Co. Ltd. | Tubulin isotype screening in cancer therapy using halichondrin b analogs |
| EP1940758B1 (en) | 2005-09-26 | 2012-11-28 | Symrise AG | Intramolecular prins reaction |
| WO2008010776A1 (en) | 2006-07-21 | 2008-01-24 | Agency For Science, Technology And Research | Aigialomycin d and derivatives thereof and their use in treating cancer or malaria or a microbial infection |
| JPWO2009014105A1 (ja) | 2007-07-20 | 2010-10-07 | 株式会社山田養蜂場本社 | 新規カルボン酸およびそれを有効成分とする抗うつ用組成物 |
| BRPI0817909B1 (pt) | 2007-10-03 | 2022-06-21 | Eisai R&D Management Co., Ltd | Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos |
| JP5134686B2 (ja) | 2007-11-16 | 2013-01-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂアナログ合成のための新規な中間体及び前記中間体に用いるための新規な脱スルホニル化反応 |
| JP6001857B2 (ja) | 2008-04-04 | 2016-10-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂ類似体 |
| JP5371091B2 (ja) | 2009-01-23 | 2013-12-18 | 三菱レイヨン株式会社 | モノスルホン酸エステルの製造方法 |
| BR112012018232B8 (pt) | 2010-01-26 | 2023-01-10 | Eisai R&D Man Co Ltd | Compostos derivados de furo [3,2-b] pirano úteis na síntese de análogos de halicondrina b e métodos de sintetização de er-80402 e de eribulina |
| WO2012147900A1 (en) | 2011-04-28 | 2012-11-01 | Eisai R&D Management Co., Ltd. | Microreactor process for halichondrin b analog synthesis |
| EP2785687B1 (en) | 2011-11-30 | 2019-02-20 | Sandoz AG | Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene |
| CN104334562A (zh) | 2012-03-30 | 2015-02-04 | 阿方拉研究股份有限公司 | 用于制备软海绵素b的大环c1-酮类似物的合成方法及其中有用的中间体 |
| AU2014286880B2 (en) | 2013-07-03 | 2017-12-14 | Sandoz Ag | Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing -SO2-(p-TOLYL) groups |
| HUE049387T2 (hu) * | 2013-11-04 | 2020-09-28 | Eisai R&D Man Co Ltd | A halichondrin B analógjainak szintézisében hasznos makrociklizációs reakciók és köztitermékek |
| SG10201805024YA (en) | 2013-12-06 | 2018-07-30 | Eisai R&D Man Co Ltd | Methods useful in the synthesis of halichondrin b analogs |
| WO2016038624A1 (en) | 2014-09-09 | 2016-03-17 | Cipla Limited | "process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof" |
| MX380284B (es) | 2015-05-07 | 2025-03-12 | Eisai R&D Man Co Ltd | Reacciones de macrociclización e intermediarios y otros fragmentos útiles en la síntesis de macrólidos de halicondrina. |
| SG11201811671XA (en) | 2016-06-30 | 2019-01-30 | Eisai R&D Man Co Ltd | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
| WO2018217894A1 (en) | 2017-05-24 | 2018-11-29 | Eisai R&D Management Co., Ltd. | Fluorine-labelled halichondrin derivatives and related methods of synthesis |
| KR20250057138A (ko) | 2018-01-03 | 2025-04-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 화합물 |
-
2017
- 2017-02-10 US US16/076,028 patent/US10676481B2/en not_active Expired - Fee Related
- 2017-02-10 MX MX2018009794A patent/MX377663B/es active IP Right Grant
- 2017-02-10 WO PCT/US2017/017501 patent/WO2017139664A1/en not_active Ceased
- 2017-02-10 SG SG11201806133UA patent/SG11201806133UA/en unknown
- 2017-02-10 EP EP17750887.6A patent/EP3413887B1/en active Active
- 2017-02-10 JP JP2018539136A patent/JP6786610B2/ja not_active Expired - Fee Related
- 2017-02-10 KR KR1020187025945A patent/KR20180107243A/ko not_active Withdrawn
- 2017-02-10 CN CN201780010903.XA patent/CN108601760A/zh active Pending
- 2017-02-10 RU RU2018132264A patent/RU2732575C2/ru active
-
2018
- 2018-07-22 IL IL260717A patent/IL260717B/en active IP Right Grant
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