RU2732575C2 - Промежуточные продукты в синтезе эрибулина и соответствующие способы синтеза - Google Patents
Промежуточные продукты в синтезе эрибулина и соответствующие способы синтеза Download PDFInfo
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- RU2732575C2 RU2732575C2 RU2018132264A RU2018132264A RU2732575C2 RU 2732575 C2 RU2732575 C2 RU 2732575C2 RU 2018132264 A RU2018132264 A RU 2018132264A RU 2018132264 A RU2018132264 A RU 2018132264A RU 2732575 C2 RU2732575 C2 RU 2732575C2
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- RU
- Russia
- Prior art keywords
- formula
- compound
- salt
- iii
- eribulin
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract description 58
- 230000015572 biosynthetic process Effects 0.000 title claims abstract description 13
- 229960003649 eribulin Drugs 0.000 title abstract description 29
- 238000003786 synthesis reaction Methods 0.000 title abstract description 8
- UFNVPOGXISZXJD-XJPMSQCNSA-N eribulin Chemical compound C([C@H]1CC[C@@H]2O[C@@H]3[C@H]4O[C@H]5C[C@](O[C@H]4[C@H]2O1)(O[C@@H]53)CC[C@@H]1O[C@H](C(C1)=C)CC1)C(=O)C[C@@H]2[C@@H](OC)[C@@H](C[C@H](O)CN)O[C@H]2C[C@@H]2C(=C)[C@H](C)C[C@H]1O2 UFNVPOGXISZXJD-XJPMSQCNSA-N 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 95
- 150000003839 salts Chemical class 0.000 claims abstract description 23
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 claims abstract description 19
- -1 lanthanide salt Chemical class 0.000 claims abstract description 10
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims abstract description 7
- 150000002825 nitriles Chemical class 0.000 claims abstract description 7
- 229910000077 silane Inorganic materials 0.000 claims abstract description 7
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- 230000008569 process Effects 0.000 claims description 16
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- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical group [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 claims description 8
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- A61P35/04—Antineoplastic agents specific for metastasis
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Peptides Or Proteins (AREA)
- Materials For Photolithography (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| RU2489437C2 (ru) | 2007-10-03 | 2013-08-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Промежуточные соединения и способы синтеза аналогов галихондрина в |
| JP5800834B2 (ja) | 2010-01-26 | 2015-10-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂ類似体の合成において有用なフロ［３，２−ｂ］ピラン誘導体 |
| CN114716453A (zh) | 2013-11-04 | 2022-07-08 | 卫材R&D管理有限公司 | 软海绵素b的类似物合成中有用的大环化反应和中间体 |
| JP6443812B2 (ja) | 2013-12-06 | 2018-12-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂ類縁体の合成に有用な方法 |
| WO2016179607A1 (en) | 2015-05-07 | 2016-11-10 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides |
| MX390072B (es) | 2016-06-30 | 2025-03-20 | Eisai R&D Man Co Ltd | Reaccion de prins e intermediarios utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos. |
| CN111868044B (zh) | 2018-01-03 | 2024-07-19 | 卫材R&D管理有限公司 | 可用于合成软海绵素大环内酯及其类似物的普林斯反应和化合物 |
| CN110568121A (zh) * | 2019-07-11 | 2019-12-13 | 山东省药学科学院 | 一种艾日布林及含艾日布林的制剂中有关物质的检测方法 |
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| RU2489437C2 (ru) * | 2007-10-03 | 2013-08-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Промежуточные соединения и способы синтеза аналогов галихондрина в |
| WO2015066729A1 (en) * | 2013-11-04 | 2015-05-07 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b |
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| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| GB9206244D0 (en) | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
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| US6870058B2 (en) | 1996-12-03 | 2005-03-22 | The Trustees Of The University Of Pennsylvania | Compounds which mimic the chemical and biological properties of discodermolide |
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| WO2016179607A1 (en) | 2015-05-07 | 2016-11-10 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides |
| MX390072B (es) | 2016-06-30 | 2025-03-20 | Eisai R&D Man Co Ltd | Reaccion de prins e intermediarios utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos. |
| WO2018217894A1 (en) | 2017-05-24 | 2018-11-29 | Eisai R&D Management Co., Ltd. | Fluorine-labelled halichondrin derivatives and related methods of synthesis |
| CN111868044B (zh) | 2018-01-03 | 2024-07-19 | 卫材R&D管理有限公司 | 可用于合成软海绵素大环内酯及其类似物的普林斯反应和化合物 |
-
2017
- 2017-02-10 MX MX2018009794A patent/MX377663B/es active IP Right Grant
- 2017-02-10 EP EP17750887.6A patent/EP3413887B1/en active Active
- 2017-02-10 WO PCT/US2017/017501 patent/WO2017139664A1/en not_active Ceased
- 2017-02-10 KR KR1020187025945A patent/KR20180107243A/ko not_active Withdrawn
- 2017-02-10 US US16/076,028 patent/US10676481B2/en not_active Expired - Fee Related
- 2017-02-10 CN CN201780010903.XA patent/CN108601760A/zh active Pending
- 2017-02-10 RU RU2018132264A patent/RU2732575C2/ru active
- 2017-02-10 SG SG11201806133UA patent/SG11201806133UA/en unknown
- 2017-02-10 JP JP2018539136A patent/JP6786610B2/ja not_active Expired - Fee Related
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2018
- 2018-07-22 IL IL260717A patent/IL260717B/en active IP Right Grant
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999065894A1 (en) * | 1998-06-17 | 1999-12-23 | Eisai Co., Ltd. | Macrocyclic analogs and methods of their use and preparation |
| RU2489437C2 (ru) * | 2007-10-03 | 2013-08-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Промежуточные соединения и способы синтеза аналогов галихондрина в |
| WO2015066729A1 (en) * | 2013-11-04 | 2015-05-07 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108601760A (zh) | 2018-09-28 |
| KR20180107243A (ko) | 2018-10-01 |
| EP3413887A1 (en) | 2018-12-19 |
| EP3413887A4 (en) | 2019-08-14 |
| US10676481B2 (en) | 2020-06-09 |
| JP2019504839A (ja) | 2019-02-21 |
| JP6786610B2 (ja) | 2020-11-18 |
| SG11201806133UA (en) | 2018-08-30 |
| US20190300542A1 (en) | 2019-10-03 |
| EP3413887B1 (en) | 2021-04-07 |
| RU2018132264A (ru) | 2020-03-12 |
| IL260717B (en) | 2020-10-29 |
| MX377663B (es) | 2025-03-11 |
| WO2017139664A8 (en) | 2018-07-26 |
| WO2017139664A1 (en) | 2017-08-17 |
| RU2018132264A3 (enExample) | 2020-04-15 |
| MX2018009794A (es) | 2018-12-17 |
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