CL2016001677A1 - 5-flúor-4-imino-3-(alquil/alquilo sustituido)-1-(arilsulfonil)-3,4-dihidropirimidin-2(1h)-ona y los procesos para su preparación. - Google Patents

5-flúor-4-imino-3-(alquil/alquilo sustituido)-1-(arilsulfonil)-3,4-dihidropirimidin-2(1h)-ona y los procesos para su preparación.

Info

Publication number
CL2016001677A1
CL2016001677A1 CL2016001677A CL2016001677A CL2016001677A1 CL 2016001677 A1 CL2016001677 A1 CL 2016001677A1 CL 2016001677 A CL2016001677 A CL 2016001677A CL 2016001677 A CL2016001677 A CL 2016001677A CL 2016001677 A1 CL2016001677 A1 CL 2016001677A1
Authority
CL
Chile
Prior art keywords
alkyl
imino
dihydropyrimidin
arylsulfonyl
fluoro
Prior art date
Application number
CL2016001677A
Other languages
English (en)
Spanish (es)
Inventor
Nakyen Choy
Jr Ronald Ross
Original Assignee
Adama Makhteshim Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adama Makhteshim Ltd filed Critical Adama Makhteshim Ltd
Publication of CL2016001677A1 publication Critical patent/CL2016001677A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/541,3-Diazines; Hydrogenated 1,3-diazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/08Hydrogen atoms or radicals containing only hydrogen and carbon atoms
    • C07D333/10Thiophene
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
CL2016001677A 2013-12-31 2016-06-29 5-flúor-4-imino-3-(alquil/alquilo sustituido)-1-(arilsulfonil)-3,4-dihidropirimidin-2(1h)-ona y los procesos para su preparación. CL2016001677A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361922582P 2013-12-31 2013-12-31
US201361922572P 2013-12-31 2013-12-31

Publications (1)

Publication Number Publication Date
CL2016001677A1 true CL2016001677A1 (es) 2016-12-09

Family

ID=53480979

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016001677A CL2016001677A1 (es) 2013-12-31 2016-06-29 5-flúor-4-imino-3-(alquil/alquilo sustituido)-1-(arilsulfonil)-3,4-dihidropirimidin-2(1h)-ona y los procesos para su preparación.

Country Status (24)

Country Link
US (8) US20150183749A1 (enExample)
EP (4) EP3862347A1 (enExample)
JP (3) JP6585057B2 (enExample)
CN (4) CN111217759A (enExample)
AP (1) AP2016009342A0 (enExample)
AU (2) AU2014373959B2 (enExample)
BR (2) BR102014033010B1 (enExample)
CA (2) CA2935601C (enExample)
CL (1) CL2016001677A1 (enExample)
CR (2) CR20160343A (enExample)
DO (1) DOP2016000163A (enExample)
EA (2) EA201691353A1 (enExample)
EC (1) ECSP16064249A (enExample)
IL (3) IL246512B (enExample)
MX (2) MX375727B (enExample)
NI (1) NI201600094A (enExample)
NZ (2) NZ722439A (enExample)
PE (1) PE20161174A1 (enExample)
PH (1) PH12016501284A1 (enExample)
SG (2) SG11201605372QA (enExample)
TW (2) TWI722979B (enExample)
UA (2) UA129860C2 (enExample)
UY (2) UY35943A (enExample)
WO (2) WO2015103144A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104902757B (zh) 2012-12-28 2019-01-08 阿达玛马克西姆股份有限公司 N-(取代的)-5-氟-4-亚氨基-3-甲基-2-氧代-3,4-二氢嘧啶-1(2h)-羧酸酯衍生物
JP6258969B2 (ja) 2012-12-28 2018-01-10 アダマ・マクテシム・リミテッド N−(置換)−5−フルオロ−4−イミノ−3−メチル−2−オキソ−3,4−ジヒドロピリミジン−1(2h)−カルボキサミド誘導体
CN112094262A (zh) 2012-12-31 2020-12-18 阿达玛马克西姆股份有限公司 作为杀真菌剂的化合物
CR20160344A (es) 2013-12-31 2016-12-19 Adama Makhteshim Ltd Mezclas fungicidas sinérgicas para el control fúngico en cereales
UA129860C2 (uk) 2013-12-31 2025-08-27 Адама Махтешім Лтд. 5-фтор-4-іміно-3-(алкіл/заміщений алкіл)-1-(арилсульфоніл)-3,4-дигідропіримідин-2(1h)-он і способи його одержання
UY36964A (es) 2015-10-27 2017-05-31 Bayer Cropscience Ag Combinaciones de principios activos que comprenden un derivado de (tio) carboxamida y un compuesto funguicida
JP6922271B2 (ja) * 2016-03-11 2021-08-18 住友化学株式会社 植物病害防除組成物及び植物病害防除方法
IL271950B2 (en) * 2017-07-17 2024-06-01 Adama Makhteshim Ltd Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2-one
CA3118729A1 (en) * 2018-11-05 2020-05-14 Adama Makhteshim Ltd. Mixtures and compositions comprising 5-fluoro-4-imino-3- methyl-1-tosyl-3,4-dihydropyrimidin-2-one, and methods of use thereof
MX2022000944A (es) 2019-07-22 2022-04-06 Adama Makhteshim Ltd Combinaciones, mezclas y composiciones fungicidas y usos de las mismas.
US12466796B2 (en) 2019-09-23 2025-11-11 Adama Makhteshim Ltd. Process for preparing 5-(fluoro-4-imino-3-methyl)-1-tosyl-3,4 dihydropyrimidine-(1H)-one and derivatives of the compound
EP4118073A1 (en) * 2020-03-09 2023-01-18 Adama Makhteshim Ltd. Process for preparing 5-fluoro-4-imino-3-methyl-1-(toluene-4-sulfonyl)-3,4-dihydro-1h-pyrimidin-2-one
PY2135531A (es) * 2020-05-04 2022-02-01 Adama Makhteshim Ltd Mezclas y composiciones que comprenden 5-fluoro-4-imino-3-metil-1-tosil-3,4-dihidropirimidin-2-ona, y métodos de uso de las mismas
US20230270113A1 (en) 2020-07-08 2023-08-31 Adama Makhteshim Ltd. Fungicidal mixtures
CA3206570A1 (en) 2021-01-27 2022-08-04 Alexandra ROSENMUND 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1 h)-one for controlling plant diseases
MX2023012897A (es) 2021-05-04 2023-12-06 Adama Makhteshim Ltd Formas cristalinas de 5-fluoro-4-imino-3-metil-1-tosil-3,4- dihidropirimidin-2-ona, y mezclas, composiciones y metodos de uso de las mismas.
EP4402131A1 (en) 2021-09-15 2024-07-24 Adama Makhteshim Ltd. Process for preparing 5-fluoro-4-imino-3-methyl-1-(toluene-4-sulfonyl)-3,4-dihydro-1h-pyrimidin-2-one
UY40172A (es) 2022-03-03 2023-10-13 Adama Makhteshim Ltd Combinaciones, mezclas y composiciones fungicidas y usos de las mismas
EP4531570A1 (en) 2022-05-26 2025-04-09 Adama Makhteshim Ltd. Fungicidal combinations, mixtures and compositions and uses thereof
EP4565066A1 (en) 2022-08-03 2025-06-11 Adama Makhteshim Ltd. 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1h)-one for fungicide-resistant fungus
CN120882310A (zh) 2023-03-09 2025-10-31 安道麦马克西姆有限公司 杀真菌组合、混合物及组合物以及其用途
EP4680029A1 (en) 2023-03-14 2026-01-21 Adama Makhteshim Ltd. Liquid compositions containing 5-(fluoro-4-imino-3-methyl)-1-tosyl-3,4 dihydropyrimidine-(1h)-one and derivatives thereof and a uv absorber
EP4683910A1 (en) 2023-03-23 2026-01-28 Adama Makhteshim Ltd. Process for preparing 5-fluoro-4-imino-3-methyl-1-(toluene-4-sulfonyl)-3,4-dihydro-1h-pyrimidin-2-one
AU2024334814A1 (en) 2023-08-31 2026-03-12 Adama Makhteshim Ltd. Fungicidal combinations, mixtures and compositions and uses thereo
IL308593A (en) 2023-11-15 2025-06-01 Adama Makhteshim Ltd Reducing environmental impact of fungicidal enhancement
WO2025114931A1 (en) 2023-11-28 2025-06-05 Adama Makhteshim Ltd. Fungicidal combinations, mixtures and compositions and uses thereof
WO2025203024A1 (en) 2024-03-26 2025-10-02 Adama Makhteshim Ltd. Process for preparing 5-fluoro-4-imino-3-methyl-1-(toluene-4-sulfonyl)-3,4-dihydro-1h-pyrimidin-2-one
WO2026038217A1 (en) 2024-08-15 2026-02-19 Adama Makhteshim Ltd. Mixtures and compositions comprising flumetylsulforim and methods of use thereof

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3309359A (en) 1965-10-22 1967-03-14 Hoffmann La Roche N-mono-acyl-5-fluorocytosine derivatives and process
US3368938A (en) 1966-01-13 1968-02-13 Hoffmann La Roche Controlling fungi with 5-fluorocytosine
US3635977A (en) 1969-11-03 1972-01-18 American Cyanamid Co Certain 6-trifluoromethylcytosines and thiocytosines their synthesis and their use in the synthesis of uracisls and thiouracil
US3868373A (en) 1970-01-27 1975-02-25 Hoffmann La Roche 4-Amino-5-fluoro-2-tri(lower alkyl) silyloxypyrimidines
US4009272A (en) 1971-10-23 1977-02-22 Bayer Aktiengesellschaft Penicillins
CH579057A5 (enExample) 1973-09-07 1976-08-31 Hoffmann La Roche
JPS601793B2 (ja) 1979-12-06 1985-01-17 松下電器産業株式会社 カラ−テレビジョン受像機の画質改善装置
FR2530636A1 (fr) 1982-07-23 1984-01-27 Rhone Poulenc Agrochimie Nouveaux derives de la tetrahydro-2,3,6,7 5h-thiazolo (3,2-a) pyrimidine, leur preparation et leur utilisation comme herbicides
EP0139613A1 (de) 1983-08-29 1985-05-02 Ciba-Geigy Ag N-(2-Nitrophenyl)-4-aminopyrimidin-Derivate, deren Herstellung und Verwendung
US4845081A (en) 1984-10-18 1989-07-04 University Of Florida Aminomethyl derivatives of biologically active substances, and enhanced delivery thereof across topical membranes
EP0230922A2 (de) 1986-01-21 1987-08-05 Boehringer Ingelheim Kg Verwendung von Peptiden zur Herstellung von Mitteln zur Behandlung von Coronarerkrankungen oder organischem Hirnsyndrom
ATE109776T1 (de) 1988-03-09 1994-08-15 Ciba Geigy Ag Mittel zum schutz von pflanzen gegen krankheiten.
DE3821711A1 (de) 1988-06-28 1990-02-08 Bayer Ag Thiazolopyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
US5118816A (en) * 1990-12-26 1992-06-02 American Cyanamid Company 2-aryl-5-(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles
JP3109012B2 (ja) 1992-06-18 2000-11-13 クミアイ化学工業株式会社 チアゾロ[5,4−d]ピリミジン誘導体及び農園芸用殺菌剤
JP3217191B2 (ja) 1992-07-16 2001-10-09 ビーエーエスエフ アクチェンゲゼルシャフト ヘテロ芳香族化合物およびこれを含有する植物保護剤
EP0836602B1 (en) 1995-07-05 2002-01-30 E.I. Du Pont De Nemours And Company Fungicidal pyrimidinones
DE69712331T2 (de) 1996-03-11 2002-11-28 Syngenta Participations Ag, Basel Pyrimidin-4-on derivate als pestizidesmittel
HRP970239B1 (en) * 1997-05-09 2004-04-30 Inst Ru Er Bouekovic Process for the preparation of sulfonyl-pyrimidine derivatives with antitumor activity
GT199900185A (es) 1998-11-06 2001-04-18 Novedosa pirimidin-4-enamina como fungicida.
AU1201502A (en) 2000-10-13 2002-04-22 Shire Biochem Inc Dioxolane analogs for improved inter-cellular delivery
US7914799B2 (en) 2001-08-27 2011-03-29 Immunitor USA, Inc. Anti-fungal composition
US20080269238A1 (en) 2004-04-01 2008-10-30 Takeda Pharmaceutical Company Limited Thiazolopyrimidine Derivative
CA2629295A1 (en) 2005-11-22 2007-05-31 Ishihara Sangyo Kaisha, Ltd. Germicide composition for agricultural and gardening applications and method for controlling plant disease
US20080004253A1 (en) 2006-06-30 2008-01-03 Bryan James Branstetter Thiazolopyrimidine modulators of TRPV1
US20100029483A1 (en) 2006-10-16 2010-02-04 Rhodia Inc. Agricultural adjuvant compositions, pesticide compositions, and methods for using such compositions
WO2008047869A1 (fr) 2006-10-20 2008-04-24 Sumitomo Metal Industries, Ltd. Matériau de nickel pour installation chimique
US20100056468A1 (en) 2007-01-08 2010-03-04 University Health Network Pyrimidine Derivatives As Anticancer Agents
EP2562166B1 (en) 2008-01-22 2015-08-19 Dow AgroSciences LLC 5-fluoro pyrimidine derivatives as fungicides
EP2317851B1 (en) 2008-08-01 2014-01-15 Dow AgroSciences LLC Use of 5-fluorocytosine as a fungicide
EP2326327B1 (en) 2008-09-17 2016-03-23 SRI International Analogs of indole-3-carbinol and their use as agents against infection
PL2389375T3 (pl) 2009-01-23 2015-11-30 Euro Celtique Sa Pochodne kwasu hydroksamowego
UA106889C2 (uk) 2009-08-07 2014-10-27 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Похідні n1-ацил-5-фторпіримідинону
AU2010279408B2 (en) 2009-08-07 2015-09-10 Adama Makhteshim Ltd. 5-fluoro-2-oxopyrimidine- 1(2H)-carboxylate derivatives
UA112284C2 (uk) 2009-08-07 2016-08-25 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Похідні 5-фторпіримідинону
JP5784603B2 (ja) * 2009-08-07 2015-09-24 ダウ アグロサイエンシィズ エルエルシー N1−スルホニル−5−フルオロピリミジノン誘導体
UA107671C2 (en) 2009-08-07 2015-02-10 Dow Agrosciences Llc N1-substityted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives
CA2776562A1 (en) 2009-10-07 2011-04-14 Dow Agrosciences Llc Synergistic fungicidal composition containing 5-fluorocytosine for fungal control in cereals
ES2588742T3 (es) 2010-04-26 2016-11-04 Adama Makhteshim Ltd Derivados de N1-sulfonil-5-fluoropirimidinona N3-sustituida
RS56609B1 (sr) * 2011-08-17 2018-02-28 Adama Makhteshim Ltd 1-supstituisani derivati 5-fluor-3,6-dihidro-6-imino-2(1h)-pirimidinona kao fungicidna sredstva za upotrebu u proizvodnji bilja
US9385377B2 (en) 2012-11-07 2016-07-05 Toyota Jidosha Kabushiki Kaisha Method for producing a catalyst for fuel cells
JP6258969B2 (ja) 2012-12-28 2018-01-10 アダマ・マクテシム・リミテッド N−(置換)−5−フルオロ−4−イミノ−3−メチル−2−オキソ−3,4−ジヒドロピリミジン−1(2h)−カルボキサミド誘導体
CN104902757B (zh) * 2012-12-28 2019-01-08 阿达玛马克西姆股份有限公司 N-(取代的)-5-氟-4-亚氨基-3-甲基-2-氧代-3,4-二氢嘧啶-1(2h)-羧酸酯衍生物
WO2014105821A1 (en) 2012-12-28 2014-07-03 Dow Agrosciences Llc 1-(substituted-benzoyl)-5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1h)-one derivatives
CN112094262A (zh) * 2012-12-31 2020-12-18 阿达玛马克西姆股份有限公司 作为杀真菌剂的化合物
CR20160344A (es) 2013-12-31 2016-12-19 Adama Makhteshim Ltd Mezclas fungicidas sinérgicas para el control fúngico en cereales
UA129860C2 (uk) 2013-12-31 2025-08-27 Адама Махтешім Лтд. 5-фтор-4-іміно-3-(алкіл/заміщений алкіл)-1-(арилсульфоніл)-3,4-дигідропіримідин-2(1h)-он і способи його одержання
MA41272A (fr) 2014-12-23 2017-10-31 Adama Makhteshim Ltd 5-fluoro-4-imino-3-(alkyle/alkyle substitué)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one en tant que traitement des semences

Also Published As

Publication number Publication date
EP3097096A1 (en) 2016-11-30
EP3097096A4 (en) 2017-10-11
JP2017501197A (ja) 2017-01-12
PH12016501284A1 (en) 2016-08-15
CN111217759A (zh) 2020-06-02
AU2014373959A1 (en) 2016-08-11
EP3094632A4 (en) 2017-10-18
IL246511B (en) 2019-10-31
WO2015103142A1 (en) 2015-07-09
JP2019218396A (ja) 2019-12-26
IL269694A (en) 2019-11-28
IL269694B (en) 2021-09-30
MX392211B (es) 2025-03-21
UY35943A (es) 2015-07-31
US20150183749A1 (en) 2015-07-02
AU2014373961A1 (en) 2016-08-11
IL246511A0 (en) 2016-08-31
TW201609670A (zh) 2016-03-16
CN106061972B (zh) 2020-01-17
SG11201605377VA (en) 2016-08-30
CA2935594C (en) 2022-05-03
AU2014373961B2 (en) 2017-10-26
NZ722439A (en) 2018-01-26
PE20161174A1 (es) 2016-10-26
US20200148649A1 (en) 2020-05-14
BR102014033010A2 (pt) 2015-10-20
US20150183750A1 (en) 2015-07-02
EP3862347A1 (en) 2021-08-11
EA201691353A1 (ru) 2016-12-30
CA2935601C (en) 2023-03-14
AU2014373959B2 (en) 2017-10-26
EP3862346A1 (en) 2021-08-11
TWI722979B (zh) 2021-04-01
MX2016008758A (es) 2017-05-09
TWI667229B (zh) 2019-08-01
EA036389B1 (ru) 2020-11-03
DOP2016000163A (es) 2016-09-30
JP2017502963A (ja) 2017-01-26
NZ722438A (en) 2018-01-26
CA2935594A1 (en) 2015-07-09
CA2935601A1 (en) 2015-07-09
AP2016009342A0 (en) 2016-07-31
US20180072686A1 (en) 2018-03-15
JP6585057B2 (ja) 2019-10-02
IL246512A0 (en) 2016-08-31
CR20210172A (es) 2021-05-11
CN106068268A (zh) 2016-11-02
CN111362881A (zh) 2020-07-03
UA129860C2 (uk) 2025-08-27
ECSP16064249A (es) 2019-07-31
WO2015103144A1 (en) 2015-07-09
SG11201605372QA (en) 2016-08-30
US9850215B2 (en) 2017-12-26
EA201691351A1 (ru) 2016-12-30
CN106061972A (zh) 2016-10-26
US20160280663A1 (en) 2016-09-29
BR102014033010B1 (pt) 2021-07-13
IL246512B (en) 2019-09-26
UA122200C2 (uk) 2020-10-12
NI201600094A (es) 2016-08-09
US10919864B2 (en) 2021-02-16
MX375727B (es) 2025-03-06
TW201609669A (zh) 2016-03-16
BR102014033037B1 (pt) 2021-07-13
UY35942A (es) 2015-07-31
EP3094632A1 (en) 2016-11-23
BR102014033037A2 (pt) 2015-11-17
JP6804297B2 (ja) 2020-12-23
MX2016008759A (es) 2017-05-09
US20200024238A1 (en) 2020-01-23
CR20160343A (es) 2016-12-14
US20190308941A1 (en) 2019-10-10
US9840476B2 (en) 2017-12-12
US20160280662A1 (en) 2016-09-29

Similar Documents

Publication Publication Date Title
CL2016001677A1 (es) 5-flúor-4-imino-3-(alquil/alquilo sustituido)-1-(arilsulfonil)-3,4-dihidropirimidin-2(1h)-ona y los procesos para su preparación.
PH12018500718A1 (en) Compounds useful as modulators of trpm8
MX362582B (es) Compuestos triciclicos fusionados de urea como inhibidores de raf quinasa y/o dimero de raf quinasa.
CU20180001A7 (es) Derivados de oxopiridina sustituidos y procesos para su preparación
EA201591728A1 (ru) Гетероциклические соединения и способы их применения
UY34632A (es) Compuestos de oxazolidin- 2- ona y usos de los mismos
DK3066085T3 (da) Fremgangsmåde til syntesen af en indolamin-2,3-dioxygenaseinhibitor
EA201692219A1 (ru) Способы получения противовирусных соединений
MX2019013645A (es) Inhibidores de quinasa y usos de los mismos.
PY1432622A (es) Polimorfo de inhibidores de tirosina quinasa de bazo (syk)
UY35653A (es) Nuevos derivados de indol y de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
BR112019025028A2 (pt) Método para preparar um composto.
MX2018007219A (es) Metodos para preparacion de compuestos heterociclicos de 1,3-benzodioxol.
BR112016029510A2 (pt) métodos para a preparação de um composto, e, composto intermediário.
CY1121116T1 (el) Νεα μεθοδος για την συνθεση αγομελατινης
CL2017002255A1 (es) Procesos para preparar fluorocetólidos.
EP2970290A4 (en) CRYSTALLINE FORM OF AN ANSWERING CONNECTION
EA201690294A1 (ru) Новые соединения и их применение для получения tau-визуализирующих агентов и tau-визуализирующих составов
DK3356329T3 (da) Fremgangsmåde til fremstilling af 1-(4-methansulfonyl-2-trifluormethylbenzyl)-2-methyl-1H-pyrrolo[2,3-B]pyridin-3-yleddikesyre
TH1601003880A (th) 5-ฟลูออโร-4-อิมิโน-3-(แอลคิล/ซับสทิทิวเทด แอลคิล)-1-(แอริลซัลโฟนิล)-3,4- ไดไฮโดรพิริมิดิน-2(1h)-โอนและกรรมวิธีสำหรับการเตรียมมัน
IN2013CH05394A (enExample)
HK1231066A1 (en) 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1- (arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one and processes for their preparation
HK1231065A1 (en) 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one and processes for their preparation
CR20130484A (es) Método para perparar compuestos macrocíclicos inhibidores de serina proteasas de hepatitis c
TH1601000381A (th) สารประกอบอินโดไลซีนแบบใหม่, กระบวนการในการเตรียมสารประกอบดังกล่าว และองค์ประกอบทางเภสัชกรรมที่ประกอบด้วยสารประกอบดังกล่าว