EA201690294A1 - Новые соединения и их применение для получения tau-визуализирующих агентов и tau-визуализирующих составов - Google Patents

Новые соединения и их применение для получения tau-визуализирующих агентов и tau-визуализирующих составов

Info

Publication number
EA201690294A1
EA201690294A1 EA201690294A EA201690294A EA201690294A1 EA 201690294 A1 EA201690294 A1 EA 201690294A1 EA 201690294 A EA201690294 A EA 201690294A EA 201690294 A EA201690294 A EA 201690294A EA 201690294 A1 EA201690294 A1 EA 201690294A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tau
visualizing
compositions
application
obtaining
Prior art date
Application number
EA201690294A
Other languages
English (en)
Other versions
EA028426B1 (ru
Inventor
Джорджио Аттардо
Джон Листер-Джэймс
Натаниэль Энтони Ко Лим
Хуй Сюн
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201690294A1 publication Critical patent/EA201690294A1/ru
Publication of EA028426B1 publication Critical patent/EA028426B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein

Abstract

Описаны новые триметиламмониевые соединения формулыспособы получения указанных соединений, способы применения указанных соединений для получения tau-визуализирующих агентов и получение составов tau-визуализирующих агентов.
EA201690294A 2013-09-26 2014-09-19 СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ ДЛЯ ПОЛУЧЕНИЯ tau-ВИЗУАЛИЗИРУЮЩИХ АГЕНТОВ И tau-ВИЗУАЛИЗИРУЮЩИХ СОСТАВОВ EA028426B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361882769P 2013-09-26 2013-09-26
PCT/US2014/056503 WO2015047902A1 (en) 2013-09-26 2014-09-19 Compounds and their use for preparation of tau imaging agents and tau imaging formulations

Publications (2)

Publication Number Publication Date
EA201690294A1 true EA201690294A1 (ru) 2016-06-30
EA028426B1 EA028426B1 (ru) 2017-11-30

Family

ID=51690452

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690294A EA028426B1 (ru) 2013-09-26 2014-09-19 СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ ДЛЯ ПОЛУЧЕНИЯ tau-ВИЗУАЛИЗИРУЮЩИХ АГЕНТОВ И tau-ВИЗУАЛИЗИРУЮЩИХ СОСТАВОВ

Country Status (13)

Country Link
US (1) US20160228586A1 (ru)
EP (1) EP3049414A1 (ru)
JP (1) JP2016531851A (ru)
KR (1) KR101808969B1 (ru)
CN (1) CN105579454A (ru)
AR (1) AR097683A1 (ru)
AU (1) AU2014327076B2 (ru)
CA (1) CA2920402A1 (ru)
EA (1) EA028426B1 (ru)
HK (1) HK1222654A1 (ru)
MX (1) MX2016003725A (ru)
TW (1) TW201605852A (ru)
WO (1) WO2015047902A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106588915B (zh) * 2016-10-26 2018-12-04 浙江大学 阿兹海默症tau蛋白诊疗一体靶向药物前体的合成方法
JP7260521B2 (ja) * 2017-07-12 2023-04-18 ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド タウタンパク質分解の化合物
TWI653052B (zh) 2017-11-17 2019-03-11 國立臺灣大學 ［<sup></sup>Ｆ］Ｔ８０７衍生物的製備及用途
KR102215255B1 (ko) * 2019-06-12 2021-02-15 한국과학기술연구원 타우 응집체에 선택적으로 결합하는 형광 탐침자로서 유효한 신규 화합물 및 이의 제조 방법
CN114539250B (zh) * 2022-03-04 2023-08-29 上海裕兰生物科技有限公司 一种阿尔兹海默症PET-tau示踪剂的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4311247A1 (de) * 1993-04-06 1994-10-13 Bayer Ag Verfahren zur Herstellung von 2-Halogen-pyridin-derivaten
DE4212595A1 (de) * 1992-02-19 1993-08-26 Bayer Ag Verfahren zur herstellung von 2-chlor-5-methyl-pyridin
US8932557B2 (en) * 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
GB0905438D0 (en) * 2009-03-30 2009-05-13 Ge Healthcare Ltd Radiolabelling reagents and methods
AU2010282483B2 (en) * 2009-08-14 2014-09-04 Opko Health, Inc. Intravenous formulations of neurokinin-1 antagonists
PT2686302T (pt) * 2011-03-16 2016-11-02 Mitsubishi Tanabe Pharma Corp Compostos de sulfonamida tendo atividade antagonista de trpm8
DE102011052348B3 (de) 2011-08-01 2013-02-07 Abx Advanced Biochemical Compounds Gmbh Präkursorverbindungen für die Radiosynthese von [18F]Norchlor-fluor-homoepibatidin
KR101353443B1 (ko) * 2012-02-07 2014-01-29 주식회사 아미팜 데옥시콜린산 나트륨이 없는 포스파티딜콜린 함유 주사제 조성물 및 이의 제조방법

Also Published As

Publication number Publication date
EA028426B1 (ru) 2017-11-30
KR20160045143A (ko) 2016-04-26
TW201605852A (zh) 2016-02-16
AU2014327076B2 (en) 2016-12-22
US20160228586A1 (en) 2016-08-11
CN105579454A (zh) 2016-05-11
CA2920402A1 (en) 2015-04-02
MX2016003725A (es) 2016-05-31
EP3049414A1 (en) 2016-08-03
AR097683A1 (es) 2016-04-06
AU2014327076A1 (en) 2016-02-18
HK1222654A1 (zh) 2017-07-07
WO2015047902A1 (en) 2015-04-02
KR101808969B1 (ko) 2017-12-13
JP2016531851A (ja) 2016-10-13

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU