IL246511B - 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidine-2(h1)-one and processes for their preparation - Google Patents

5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidine-2(h1)-one and processes for their preparation

Info

Publication number
IL246511B
IL246511B IL24651116A IL24651116A IL246511B IL 246511 B IL246511 B IL 246511B IL 24651116 A IL24651116 A IL 24651116A IL 24651116 A IL24651116 A IL 24651116A IL 246511 B IL246511 B IL 246511B
Authority
IL
Israel
Prior art keywords
alkyl
dihydropyrimidin
arylsulfonyl
imino
fluoro
Prior art date
Application number
IL24651116A
Other languages
English (en)
Hebrew (he)
Other versions
IL246511A0 (en
Original Assignee
Adama Makhteshim Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adama Makhteshim Ltd filed Critical Adama Makhteshim Ltd
Publication of IL246511A0 publication Critical patent/IL246511A0/en
Publication of IL246511B publication Critical patent/IL246511B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/541,3-Diazines; Hydrogenated 1,3-diazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/08Hydrogen atoms or radicals containing only hydrogen and carbon atoms
    • C07D333/10Thiophene
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Health & Medical Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL24651116A 2013-12-31 2016-06-28 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidine-2(h1)-one and processes for their preparation IL246511B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361922582P 2013-12-31 2013-12-31
US201361922572P 2013-12-31 2013-12-31
PCT/US2014/072566 WO2015103142A1 (en) 2013-12-31 2014-12-29 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1- (arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one and processes for their preparation

Publications (2)

Publication Number Publication Date
IL246511A0 IL246511A0 (en) 2016-08-31
IL246511B true IL246511B (en) 2019-10-31

Family

ID=53480979

Family Applications (3)

Application Number Title Priority Date Filing Date
IL24651116A IL246511B (en) 2013-12-31 2016-06-28 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidine-2(h1)-one and processes for their preparation
IL246512A IL246512B (en) 2013-12-31 2016-06-28 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidine-2(h1)-one and processes for their preparation
IL269694A IL269694B (en) 2013-12-31 2019-09-26 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-4,3-dihydropyrimidine-2(h1)-one and processes for their preparation

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL246512A IL246512B (en) 2013-12-31 2016-06-28 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidine-2(h1)-one and processes for their preparation
IL269694A IL269694B (en) 2013-12-31 2019-09-26 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-4,3-dihydropyrimidine-2(h1)-one and processes for their preparation

Country Status (24)

Country Link
US (8) US20150183750A1 (enExample)
EP (4) EP3862346A1 (enExample)
JP (3) JP6804297B2 (enExample)
CN (4) CN106068268A (enExample)
AP (1) AP2016009342A0 (enExample)
AU (2) AU2014373959B2 (enExample)
BR (2) BR102014033010B1 (enExample)
CA (2) CA2935594C (enExample)
CL (1) CL2016001677A1 (enExample)
CR (2) CR20160343A (enExample)
DO (1) DOP2016000163A (enExample)
EA (2) EA036389B1 (enExample)
EC (1) ECSP16064249A (enExample)
IL (3) IL246511B (enExample)
MX (2) MX392211B (enExample)
NI (1) NI201600094A (enExample)
NZ (2) NZ722438A (enExample)
PE (1) PE20161174A1 (enExample)
PH (1) PH12016501284A1 (enExample)
SG (2) SG11201605377VA (enExample)
TW (2) TWI722979B (enExample)
UA (2) UA129860C2 (enExample)
UY (2) UY35942A (enExample)
WO (2) WO2015103144A1 (enExample)

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AU2013370493B2 (en) 2012-12-28 2017-08-17 Adama Makhteshim Ltd. N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1 (2H)-carboxylate derivatives
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FI3096619T3 (fi) 2013-12-31 2025-09-03 Adama Makhteshim Ltd Synergistisiä sienituhoaineseoksia sienten torjuntaan viljakasveissa
EA036389B1 (ru) 2013-12-31 2020-11-03 Адама Мактешим Лтд. 5-фтор-4-имино-3-(алкил/замещенный алкил)-1-(арилсульфонил)-3,4-дигидропиримидин-2(1h)-он и способы их получения
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EP3655396A1 (en) * 2017-07-17 2020-05-27 Adama Makhteshim Ltd. Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2-one
US12414559B2 (en) 2018-11-05 2025-09-16 Adama Makhteshim Ltd. Mixtures and compositions comprising 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2-one, and methods of use thereof
CA3295216A1 (en) 2019-07-22 2026-03-02 Adama Makhteshim Ltd. Fungicidal combinations, mixtures and compositions and uses thereof
WO2021059160A1 (en) 2019-09-23 2021-04-01 Adama Makhteshim Ltd. Process for preparing 5-(fluoro-4-imino-3-methyl)-1-tosyl-3,4 dihydropyrimidine -(1h)-one
CN115776980A (zh) * 2020-03-09 2023-03-10 阿达玛马克西姆有限公司 用于制备5-氟-4-亚氨基-3-甲基-1-(甲苯-4-磺酰基)-3,4-二氢-1h-嘧啶-2-酮的方法
WO2021224802A1 (en) * 2020-05-04 2021-11-11 Adama Makhteshim Ltd. Mixtures and compositions comprising 5-fluoro-4-imino-3- methyl-1-tosyl-3,4-dihydropyrimidin-2-one, and methods of use thereof
BR112023000205A2 (pt) 2020-07-08 2023-04-25 Adama Makhteshim Ltd Misturas fungicidas
PE20250069A1 (es) 2021-01-27 2025-01-13 Adama Makhteshim Ltd 5-fluoro-4-imino-3-metil-1-tosil-3,4-dihidropirimidin-2(1h)-ona para control de enfermedades de plantas
AU2022268726A1 (en) 2021-05-04 2023-11-23 Adama Makhteshim Ltd. Crystalline forms of 5-fluoro-4-imino-3-methyl-1-tosyl-3,4- dihydropyrimidin-2-one, and mixtures, compositions and methods of use thereof
CN118139845A (zh) 2021-09-15 2024-06-04 安道麦马克西姆有限公司 用于制备5-氟-4-亚氨基-3-甲基-1-(甲苯-4-磺酰基)-3,4-二氢-1h-嘧啶-2-酮的方法
UY40172A (es) 2022-03-03 2023-10-13 Adama Makhteshim Ltd Combinaciones, mezclas y composiciones fungicidas y usos de las mismas
AU2023275068A1 (en) 2022-05-26 2024-11-28 Adama Makhteshim Ltd. Fungicidal combinations, mixtures and compositions and uses thereof
PY2361414A (es) 2022-08-03 2024-02-21 Adama Makhteshim Ltd 5-fluoro-4-imino-3-metil-1-tosil -3,4-dihidropirimidin-2(1h)-ona para hongos resistentes a fungicidas
CN120882310A (zh) 2023-03-09 2025-10-31 安道麦马克西姆有限公司 杀真菌组合、混合物及组合物以及其用途
EP4680029A1 (en) 2023-03-14 2026-01-21 Adama Makhteshim Ltd. Liquid compositions containing 5-(fluoro-4-imino-3-methyl)-1-tosyl-3,4 dihydropyrimidine-(1h)-one and derivatives thereof and a uv absorber
CN121001998A (zh) 2023-03-23 2025-11-21 安道麦马克西姆有限公司 用于制备5-氟-4-亚氨基-3-甲基-1-(甲苯-4-磺酰基)-3,4-二氢-1h-嘧啶-2-酮的方法
IL326694A (en) 2023-08-31 2026-04-01 Adama Makhteshim Ltd Fungal combinations Mixtures, compositions and uses
IL308593A (en) 2023-11-15 2025-06-01 Adama Makhteshim Ltd Reducing environmental impact of fungicidal enhancement
WO2025114931A1 (en) 2023-11-28 2025-06-05 Adama Makhteshim Ltd. Fungicidal combinations, mixtures and compositions and uses thereof
WO2025203024A1 (en) 2024-03-26 2025-10-02 Adama Makhteshim Ltd. Process for preparing 5-fluoro-4-imino-3-methyl-1-(toluene-4-sulfonyl)-3,4-dihydro-1h-pyrimidin-2-one
WO2026038217A1 (en) 2024-08-15 2026-02-19 Adama Makhteshim Ltd. Mixtures and compositions comprising flumetylsulforim and methods of use thereof
WO2026083211A1 (en) 2024-10-16 2026-04-23 Adama Makhteshim Ltd. Mixtures and composition comprising thereof

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FI3096619T3 (fi) 2013-12-31 2025-09-03 Adama Makhteshim Ltd Synergistisiä sienituhoaineseoksia sienten torjuntaan viljakasveissa
EA036389B1 (ru) 2013-12-31 2020-11-03 Адама Мактешим Лтд. 5-фтор-4-имино-3-(алкил/замещенный алкил)-1-(арилсульфонил)-3,4-дигидропиримидин-2(1h)-он и способы их получения
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Also Published As

Publication number Publication date
JP6585057B2 (ja) 2019-10-02
CN106061972B (zh) 2020-01-17
BR102014033037B1 (pt) 2021-07-13
ECSP16064249A (es) 2019-07-31
EP3094632A1 (en) 2016-11-23
US20200024238A1 (en) 2020-01-23
EA201691351A1 (ru) 2016-12-30
EA036389B1 (ru) 2020-11-03
MX375727B (es) 2025-03-06
WO2015103142A1 (en) 2015-07-09
US20160280662A1 (en) 2016-09-29
TWI667229B (zh) 2019-08-01
TW201609669A (zh) 2016-03-16
UA129860C2 (uk) 2025-08-27
AP2016009342A0 (en) 2016-07-31
MX2016008758A (es) 2017-05-09
AU2014373959A1 (en) 2016-08-11
NZ722439A (en) 2018-01-26
BR102014033037A2 (pt) 2015-11-17
CA2935594A1 (en) 2015-07-09
PH12016501284A1 (en) 2016-08-15
JP2017502963A (ja) 2017-01-26
IL246512B (en) 2019-09-26
US20190308941A1 (en) 2019-10-10
US9850215B2 (en) 2017-12-26
CA2935594C (en) 2022-05-03
CN106068268A (zh) 2016-11-02
CN111362881A (zh) 2020-07-03
EP3094632A4 (en) 2017-10-18
IL269694B (en) 2021-09-30
US20160280663A1 (en) 2016-09-29
BR102014033010A2 (pt) 2015-10-20
CN106061972A (zh) 2016-10-26
EP3862347A1 (en) 2021-08-11
CR20160343A (es) 2016-12-14
SG11201605372QA (en) 2016-08-30
UY35942A (es) 2015-07-31
MX392211B (es) 2025-03-21
US9840476B2 (en) 2017-12-12
AU2014373961A1 (en) 2016-08-11
AU2014373961B2 (en) 2017-10-26
NZ722438A (en) 2018-01-26
EP3862346A1 (en) 2021-08-11
WO2015103144A1 (en) 2015-07-09
UY35943A (es) 2015-07-31
EP3097096A1 (en) 2016-11-30
US20180072686A1 (en) 2018-03-15
NI201600094A (es) 2016-08-09
CL2016001677A1 (es) 2016-12-09
TWI722979B (zh) 2021-04-01
TW201609670A (zh) 2016-03-16
SG11201605377VA (en) 2016-08-30
EA201691353A1 (ru) 2016-12-30
IL246511A0 (en) 2016-08-31
JP2017501197A (ja) 2017-01-12
JP2019218396A (ja) 2019-12-26
DOP2016000163A (es) 2016-09-30
US20150183749A1 (en) 2015-07-02
CA2935601A1 (en) 2015-07-09
IL246512A0 (en) 2016-08-31
US20200148649A1 (en) 2020-05-14
IL269694A (en) 2019-11-28
CR20210172A (es) 2021-05-11
EP3097096A4 (en) 2017-10-11
BR102014033010B1 (pt) 2021-07-13
US10919864B2 (en) 2021-02-16
MX2016008759A (es) 2017-05-09
CN111217759A (zh) 2020-06-02
PE20161174A1 (es) 2016-10-26
US20150183750A1 (en) 2015-07-02
AU2014373959B2 (en) 2017-10-26
JP6804297B2 (ja) 2020-12-23
CA2935601C (en) 2023-03-14
UA122200C2 (uk) 2020-10-12

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