JP2018501266A5 - - Google Patents
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- Publication number
- JP2018501266A5 JP2018501266A5 JP2017533569A JP2017533569A JP2018501266A5 JP 2018501266 A5 JP2018501266 A5 JP 2018501266A5 JP 2017533569 A JP2017533569 A JP 2017533569A JP 2017533569 A JP2017533569 A JP 2017533569A JP 2018501266 A5 JP2018501266 A5 JP 2018501266A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- independently
- optionally substituted
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000004432 carbon atom Chemical group C* 0.000 description 11
- 125000000217 alkyl group Chemical group 0.000 description 4
- 125000001188 haloalkyl group Chemical group 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20146150 | 2014-12-23 | ||
| FI20146150 | 2014-12-23 | ||
| PCT/FI2015/050930 WO2016102776A1 (en) | 2014-12-23 | 2015-12-22 | Prodrugs of 17.beta.-hsd1 -inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018501266A JP2018501266A (ja) | 2018-01-18 |
| JP2018501266A5 true JP2018501266A5 (enExample) | 2019-01-17 |
| JP6523461B2 JP6523461B2 (ja) | 2019-06-05 |
Family
ID=55221442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533569A Active JP6523461B2 (ja) | 2014-12-23 | 2015-12-22 | １７β−ＨＳＤ１−阻害剤のプロドラッグ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10413557B2 (enExample) |
| EP (1) | EP3237431B1 (enExample) |
| JP (1) | JP6523461B2 (enExample) |
| CN (1) | CN107207561B (enExample) |
| WO (1) | WO2016102776A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3237430B1 (en) * | 2014-12-23 | 2019-03-20 | Forendo Pharma Ltd | PRODRUGS OF 17ß -HSD1 -INHIBITORS |
| LT3634975T (lt) | 2017-06-08 | 2024-06-25 | Organon R&D Finland Ltd | 15.beta.-[3-propanamido]-pakeisti estra-1,3,5(10)-trien-17-onų 17-oksimai, skirti 17.beta.-hidroksisteroidų dehidrogenazių slopinimui |
| WO2023122075A1 (en) * | 2021-12-20 | 2023-06-29 | Ohio State Innovation Foundation | Compositions comprising sterol-amino-phosphate compounds and methods of making and use thereof |
| WO2025185710A1 (zh) * | 2024-03-08 | 2025-09-12 | 长春金赛药业有限责任公司 | 17β-HSD1抑制剂化合物、药物组合物及其应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2000125533A (ru) | 1998-03-11 | 2002-10-20 | Эндорешерш, Инк. (Ca) | Ингибиторы 17-бета-гидроксистероиддегидрогеназ 5 и 3 типа и способы их применения |
| DE69935335T2 (de) | 1998-08-07 | 2007-11-22 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Pyrazole als modulatoren des östrogenrezeptors |
| GB9929302D0 (en) | 1999-12-11 | 2000-02-02 | Univ Cardiff | Benzyl tetralins compositions and uses thereof |
| AU2002326823B2 (en) | 2001-09-06 | 2005-12-15 | Merck Sharp & Dohme Corp. | 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
| ES2347643T3 (es) | 2001-10-17 | 2010-11-03 | Schering Corporation | Piperin- y piperazinacetamidas como inhibidores de 17beta hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades dependientes de androgenos. |
| US6750248B2 (en) | 2001-11-09 | 2004-06-15 | National University Of Singapore | Methods for preparing an estrogenic preparation and isolated estrogenic compounds from a plant and uses thereof |
| DE60332862D1 (de) | 2002-11-18 | 2010-07-15 | Schering Corp | 17beta-hydroxysteroid dehydrogenase typ-3 hemmer zur behandlung von androgen abhängigen erkrankungen |
| CN1744930A (zh) | 2002-12-17 | 2006-03-08 | 先灵公司 | 治疗雄激素依赖性疾病的3型17β－羟基类固醇脱氢酶抑制剂 |
| US7015211B2 (en) | 2003-03-21 | 2006-03-21 | Yale University | 15α-substituted estradiol carboxylic acid esters as locally active estrogens |
| GB0306718D0 (en) * | 2003-03-24 | 2003-04-30 | Sterix Ltd | Compound |
| US7465739B2 (en) | 2003-06-10 | 2008-12-16 | Solvay Pharmaceuticals B.V. | Compounds and their use in therapy |
| US7754709B2 (en) | 2003-06-10 | 2010-07-13 | Solvay Pharmaceuticals Bv | Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds |
| US8088758B2 (en) | 2003-11-12 | 2012-01-03 | Abbott Products Gmbh | 17β-hydroxysteroid dehydrogenase type I inhibitors |
| TWI331154B (en) | 2003-11-12 | 2010-10-01 | Solvay Pharm Gmbh | Novel 17-hydroxysteroid dehydrogenase type i inhibitors |
| US7378426B2 (en) | 2004-03-01 | 2008-05-27 | Bristol-Myers Squibb Company | Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
| DE102004032673A1 (de) | 2004-07-02 | 2006-01-26 | Schering Ag | Neue 2-substituierte D-Homo-estra-1,3,5(10)-triene als Inhibitoren der 17ß-Hydroxysteroiddehydrogenase Typ 1 |
| DE102004032674A1 (de) | 2004-07-02 | 2006-01-26 | Schering Ag | Neue 2-substituierte Estra-1,3,5(10)-trien-17-one als Inhibitoren der 17β-Hydroxysteroiddehydrogenase Typ 1 |
| UA89964C2 (ru) | 2004-09-08 | 2010-03-25 | Н.В. Органон | 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ |
| AU2006251154B2 (en) | 2005-05-26 | 2012-06-28 | Solvay Pharmaceuticals Gmbh | 17beta-HSD1 and STS inhibitors |
| US8030298B2 (en) | 2005-05-26 | 2011-10-04 | Abbott Products Gmbh | 17β-HSD1 and STS inhibitors |
| RU2469042C2 (ru) | 2006-09-19 | 2012-12-10 | Зольвай Фармасьютиклз Гмбх | Терапевтически активные триазолы и их использование |
| CN101568547B (zh) | 2006-11-30 | 2014-06-25 | 索尔瓦药物有限公司 | 作为17βHSD抑制剂的被取代的雌三烯衍生物 |
| BR112015031846A8 (pt) * | 2013-06-25 | 2018-03-06 | Forendo Pharma Ltd | derivados de estratrientiazol, seus usos, e composição farmacêutica |
| US9850272B2 (en) | 2013-06-25 | 2017-12-26 | Forendo Pharma Ltd. | Therapeutically active estratrienthiazole derivatives as inhibitors of 17.beta-hydroxy-steroid dehydrogenase, type 1 |
| TW201512215A (zh) | 2013-06-25 | 2015-04-01 | Forendo Pharma Ltd | 治療活性雌三烯噻唑衍生物 |
| EP3237430B1 (en) * | 2014-12-23 | 2019-03-20 | Forendo Pharma Ltd | PRODRUGS OF 17ß -HSD1 -INHIBITORS |
-
2015
- 2015-12-22 US US15/539,184 patent/US10413557B2/en active Active
- 2015-12-22 JP JP2017533569A patent/JP6523461B2/ja active Active
- 2015-12-22 EP EP15828340.8A patent/EP3237431B1/en active Active
- 2015-12-22 WO PCT/FI2015/050930 patent/WO2016102776A1/en not_active Ceased
- 2015-12-22 CN CN201580074140.6A patent/CN107207561B/zh active Active
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