JP2017501167A5 - - Google Patents
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- JP2017501167A5 JP2017501167A5 JP2016540597A JP2016540597A JP2017501167A5 JP 2017501167 A5 JP2017501167 A5 JP 2017501167A5 JP 2016540597 A JP2016540597 A JP 2016540597A JP 2016540597 A JP2016540597 A JP 2016540597A JP 2017501167 A5 JP2017501167 A5 JP 2017501167A5
- Authority
- JP
- Japan
- Prior art keywords
- pdl1
- medicament
- antibody
- cancer
- binding antagonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 101700064281 ATP1 Proteins 0.000 claims 24
- 102100007290 CD274 Human genes 0.000 claims 24
- 101710012053 CD274 Proteins 0.000 claims 24
- 239000003814 drug Substances 0.000 claims 24
- 230000003042 antagnostic Effects 0.000 claims 21
- 239000005557 antagonist Substances 0.000 claims 21
- 102100013135 TNFRSF4 Human genes 0.000 claims 14
- 101710040448 TNFRSF4 Proteins 0.000 claims 14
- 239000000556 agonist Substances 0.000 claims 13
- 108010072668 atezolizumab Proteins 0.000 claims 13
- 239000003937 drug carrier Substances 0.000 claims 13
- 201000011510 cancer Diseases 0.000 claims 12
- 108090001123 antibodies Proteins 0.000 claims 6
- 102000004965 antibodies Human genes 0.000 claims 6
- 210000001744 T-Lymphocytes Anatomy 0.000 claims 4
- 230000035693 Fab Effects 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010017758 Gastric cancer Diseases 0.000 claims 1
- 206010073071 Hepatocellular carcinoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000038129 antigens Human genes 0.000 claims 1
- 108091007172 antigens Proteins 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000000053 blastoma Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 210000004027 cells Anatomy 0.000 claims 1
- 201000011231 colorectal cancer Diseases 0.000 claims 1
- 230000001461 cytolytic Effects 0.000 claims 1
- 201000008184 embryoma Diseases 0.000 claims 1
- 230000002708 enhancing Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 239000003292 glue Substances 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 230000036737 immune function Effects 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 108010045030 monoclonal antibodies Proteins 0.000 claims 1
- 102000005614 monoclonal antibodies Human genes 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 230000002459 sustained Effects 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361917264P | 2013-12-17 | 2013-12-17 | |
| US61/917,264 | 2013-12-17 | ||
| US201462080991P | 2014-11-17 | 2014-11-17 | |
| US62/080,991 | 2014-11-17 | ||
| PCT/US2014/070998 WO2015095423A2 (en) | 2013-12-17 | 2014-12-17 | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017501167A JP2017501167A (ja) | 2017-01-12 |
| JP2017501167A5 true JP2017501167A5 (US07794700-20100914-C00152.png) | 2018-02-01 |
Family
ID=52293264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540597A Pending JP2017501167A (ja) | 2013-12-17 | 2014-12-17 | Ｏｘ４０結合アゴニスト及びｐｄ−１軸結合アンタゴニストを含む併用療法 |
Country Status (12)
Families Citing this family (168)
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2014
- 2014-12-17 WO PCT/US2014/070998 patent/WO2015095423A2/en active Application Filing
- 2014-12-17 EP EP14824702.6A patent/EP3083687A2/en not_active Withdrawn
- 2014-12-17 CN CN201480073061.9A patent/CN106102774A/zh active Pending
- 2014-12-17 AU AU2014364606A patent/AU2014364606A1/en not_active Abandoned
- 2014-12-17 CA CA2934028A patent/CA2934028A1/en not_active Abandoned
- 2014-12-17 JP JP2016540597A patent/JP2017501167A/ja active Pending
- 2014-12-17 US US14/574,365 patent/US20150190506A1/en not_active Abandoned
- 2014-12-17 KR KR1020167018833A patent/KR20160099092A/ko not_active Application Discontinuation
- 2014-12-17 SG SG11201604979WA patent/SG11201604979WA/en unknown
- 2014-12-17 BR BR112016013963A patent/BR112016013963A2/pt not_active Application Discontinuation
- 2014-12-17 MX MX2016007965A patent/MX2016007965A/es unknown
- 2014-12-17 EP EP18206645.6A patent/EP3527587A1/en not_active Withdrawn
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2016
- 2016-06-15 IL IL246251A patent/IL246251A0/en unknown
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2018
- 2018-02-01 US US15/886,454 patent/US20180303936A1/en not_active Abandoned
