JP2015524283A - 脂肪酸および脂肪酸由来生成物の生成のため微生物および方法 - Google Patents

脂肪酸および脂肪酸由来生成物の生成のため微生物および方法 Download PDF

Info

Publication number
JP2015524283A
JP2015524283A JP2015526743A JP2015526743A JP2015524283A JP 2015524283 A JP2015524283 A JP 2015524283A JP 2015526743 A JP2015526743 A JP 2015526743A JP 2015526743 A JP2015526743 A JP 2015526743A JP 2015524283 A JP2015524283 A JP 2015524283A
Authority
JP
Japan
Prior art keywords
coa
fatty acid
malonyl
product
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015526743A
Other languages
English (en)
Japanese (ja)
Inventor
ハンス リャオ，
ハンス リャオ，
アイリーン スピンドラー，
アイリーン スピンドラー，
ジョセフ アール． ワーナー，
ジョセフ アール． ワーナー，
マイケル ルイ，
マイケル ルイ，
ウェンディ— リブル，
ウェンディ― リブル，
ブリトニー プラサー，
ブリトニー プラサー，
ロン エバンス，
ロン エバンス，
タニア イー． ダブリュー． リプスコム，
タニア イー． ダブリュー． リプスコム，
マイケル ディー． リンチ，
マイケル ディー． リンチ，
Original Assignee
オーピーエックス バイオテクノロジーズ， インコーポレイテッド
オーピーエックス バイオテクノロジーズ， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by オーピーエックス バイオテクノロジーズ， インコーポレイテッド, オーピーエックス バイオテクノロジーズ， インコーポレイテッド filed Critical オーピーエックス バイオテクノロジーズ， インコーポレイテッド
Publication of JP2015524283A publication Critical patent/JP2015524283A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01157—3-Hydroxybutyryl-CoA dehydrogenase (1.1.1.157)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
    • C12Y103/01009—Enoyl-[acyl-carrier-protein] reductase (NADH) (1.3.1.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01194—Acetoacetyl-CoA synthase (2.3.1.194)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2015526743A 2012-08-10 2013-08-09 脂肪酸および脂肪酸由来生成物の生成のため微生物および方法 Pending JP2015524283A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261682127P 2012-08-10 2012-08-10
US201261682138P 2012-08-10 2012-08-10
US61/682,127 2012-08-10
US61/682,138 2012-08-10
PCT/US2013/054422 WO2014026162A1 (en) 2012-08-10 2013-08-09 Microorganisms and methods for the production of fatty acids and fatty acid derived products

Publications (1)

Publication Number Publication Date
JP2015524283A true JP2015524283A (ja) 2015-08-24

Family

ID=50068615

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015526743A Pending JP2015524283A (ja) 2012-08-10 2013-08-09 脂肪酸および脂肪酸由来生成物の生成のため微生物および方法

Country Status (12)

Country Link
US (2) US20140051136A1 (cg-RX-API-DMAC7.html)
EP (1) EP2882843A4 (cg-RX-API-DMAC7.html)
JP (1) JP2015524283A (cg-RX-API-DMAC7.html)
KR (1) KR20150040359A (cg-RX-API-DMAC7.html)
CN (2) CN109182238A (cg-RX-API-DMAC7.html)
AU (1) AU2013299414A1 (cg-RX-API-DMAC7.html)
BR (1) BR112015002940A2 (cg-RX-API-DMAC7.html)
CA (1) CA2881666A1 (cg-RX-API-DMAC7.html)
IN (1) IN2015DN01858A (cg-RX-API-DMAC7.html)
MX (1) MX2015001780A (cg-RX-API-DMAC7.html)
SG (1) SG11201501013PA (cg-RX-API-DMAC7.html)
WO (1) WO2014026162A1 (cg-RX-API-DMAC7.html)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
CA2881666A1 (en) 2012-08-10 2014-02-13 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
WO2014146026A1 (en) 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Bioproduction of chemicals
BR112016001026A2 (pt) 2013-07-19 2017-10-24 Cargill Inc organismo geneticamente modificado
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP2843043A1 (en) 2013-08-27 2015-03-04 Evonik Industries AG A method for producing acyl amino acids
WO2015077752A1 (en) 2013-11-25 2015-05-28 Genomatica, Inc. Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol
BR112016026164B1 (pt) * 2014-05-12 2023-10-31 Metabolic Explorer Novo microrganismo e método para a produção de 1,2-propanodiol com base em acetol redutase dependente de nadph e suprimento de nadph aprimorado
EP2944697A1 (en) 2014-05-13 2015-11-18 Evonik Degussa GmbH Method of producing nylon
EP2946764A1 (en) 2014-05-23 2015-11-25 Evonik Degussa GmbH Biosynthetic production of acyl amino acids
EP2975131A1 (en) 2014-07-17 2016-01-20 Evonik Degussa GmbH Synthesis of alkanes
KR20240023194A (ko) 2014-07-18 2024-02-20 게노마티카 인코포레이티드 지방 디올의 미생물 생산
EP2993228B1 (en) * 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
EP3081639A1 (en) 2015-04-14 2016-10-19 Evonik Degussa GmbH Acyl amino acid production
EP3091080A1 (en) 2015-05-05 2016-11-09 Evonik Degussa GmbH Process for producing acyl amino acids employing lipases
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2017102952A1 (en) 2015-12-17 2017-06-22 Evonik Degussa Gmbh A genetically modified acetogenic cell
US11124813B2 (en) 2016-07-27 2021-09-21 Evonik Operations Gmbh N-acetyl homoserine
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11345938B2 (en) 2017-02-02 2022-05-31 Cargill, Incorporated Genetically modified cells that produce C6-C10 fatty acid derivatives
US11180739B2 (en) 2017-02-27 2021-11-23 Duke University In vivo protein N-acylation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009529890A (ja) * 2006-03-15 2009-08-27 マーテック バイオサイエンシーズ コーポレーション Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法
JP2010527612A (ja) * 2007-05-22 2010-08-19 エルエス９・インコーポレイテッド 炭化水素産生遺伝子およびその使用方法
US20100274033A1 (en) * 2009-04-27 2010-10-28 Ls9, Inc. Production of fatty acid esters
JP2010259388A (ja) * 2009-05-08 2010-11-18 Toyota Motor Corp ブタノール生産能を有する組換え微生物及びブタノールの製造方法

Family Cites Families (265)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2406889A (en) 1942-12-14 1946-09-03 Manning Maxwell & Moore Inc Power unit for traveling cranes
US2464768A (en) 1946-02-13 1949-03-15 American Cyanamid Co Preparation of esters of acrylic acid
US2469701A (en) 1946-02-13 1949-05-10 American Cyanamid Co Preparation of acrylic acid
US2798053A (en) 1952-09-03 1957-07-02 Goodrich Co B F Carboxylic polymers
US3687885A (en) 1970-04-15 1972-08-29 Du Pont Water base paints having an improved balance of anti-drip and leveling qualities
US3872037A (en) 1970-12-11 1975-03-18 Polysar Ltd Improved carboxylic latex for paper coating utilizing butadiene-styrene-acrylic acid-acrolein tetrapolymers
GB1349586A (en) 1970-12-11 1974-04-03 Polysar Ltd Latex composition and process for producing the same
US3904685A (en) 1973-07-20 1975-09-09 Celanese Corp Polyacrylic acid having high chelation value and its production
US3891591A (en) 1973-08-13 1975-06-24 Du Pont Coating compositions
US3915921A (en) 1974-07-02 1975-10-28 Goodrich Co B F Unsaturated carboxylic acid-long chain alkyl ester copolymers and tri-polymers water thickening agents and emulsifiers
US4029577A (en) 1975-11-17 1977-06-14 Betz Laboratories, Inc. Polymers for use in water treatment
DE2757329C2 (de) 1977-12-22 1980-02-07 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Polymerisaten der Acrylsäure oder Methacrylsäure
US4268641A (en) 1979-04-24 1981-05-19 Union Carbide Corporation Acrylic acid-acrylate copolymer thickening agents
US4431547A (en) 1981-08-24 1984-02-14 Nalco Chemical Company Use of acrylamide/acrylic acid copolymers for prevention of fouling by Ca3 (PO4)2
US4985518A (en) 1981-10-26 1991-01-15 American Colloid Company Process for preparing water-absorbing resins
JPS58180233A (ja) 1982-04-19 1983-10-21 Nippon Shokubai Kagaku Kogyo Co Ltd 吸収剤
US4685915A (en) 1984-04-06 1987-08-11 The Procter & Gamble Company Disposable diaper having density and basis weight profiled absorbent core
US4734478A (en) 1984-07-02 1988-03-29 Nippon Shokubai Kagaku Kogyo Co., Ltd. Water absorbing agent
US4708997A (en) 1985-07-22 1987-11-24 The Dow Chemical Company Suspending agent for the suspension polymerization of water-soluble monomers
DE3544770A1 (de) 1985-12-18 1987-06-19 Stockhausen Chem Fab Gmbh Verfahren und vorrichtung zum kontinuierlichen herstellen von polymerisaten und copolymerisaten der acrylsaeure und/oder methacrylsaeure
US5009653A (en) 1988-03-31 1991-04-23 The Procter & Gamble Company Thin, flexible sanitary napkin
US4952505A (en) 1988-08-08 1990-08-28 Florida State University Fermentation of trichoderma reesei and apparatus therefor
US5487989A (en) 1988-08-31 1996-01-30 Bioenergy International, L.C. Ethanol production by recombinant hosts
IT1229506B (it) 1989-01-26 1991-09-03 Sigma Prodotti Chimici Srl Polimero dell'acido acrilico esente da solventi residui e procedimento per la sua preparazione.
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US5145906A (en) 1989-09-28 1992-09-08 Hoechst Celanese Corporation Super-absorbent polymer having improved absorbency properties
JP2938920B2 (ja) 1990-01-31 1999-08-25 住友精化株式会社 吸水性樹脂の製造方法
US5350799A (en) 1990-05-31 1994-09-27 Hoechst Celanese Corporation Process for the conversion of fine superabsorbent polymer particles into larger particles
US5342899A (en) 1991-05-16 1994-08-30 The Dow Chemical Company Process for recycling aqueous fluid absorbents fines to a polymerizer
US5135617A (en) 1991-07-01 1992-08-04 Phillips Petroleum Company Separation of aromatic from olefinic hydrocarbons by extractive distillation
DE4138408A1 (de) 1991-11-22 1993-05-27 Cassella Ag Hydrophile, hochquellfaehige hydrogele
CA2083346A1 (en) 1991-12-13 1993-06-14 Eric G. Lundquist A catalyzed esterification process
US5142023A (en) 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5827255A (en) 1992-07-27 1998-10-27 The Procter & Gamble Company Sanitary napkin comprising an absorbent core having a density gradient
US5405913A (en) 1993-03-22 1995-04-11 The University Of Akron Free radical copper(II)-enolate polymerization initiators
US5510307A (en) 1993-04-08 1996-04-23 Isp Investments Inc. Free radical initiator delivery system
US5510526A (en) 1993-06-29 1996-04-23 Cargill, Incorporated Lactic acid production, separation and/or recovery process
ATE220099T1 (de) 1993-08-24 2002-07-15 Ajinomoto Kk Eine phosphoenolpyruvat-carboxylasevariante, ihr gen und verfahren zur herstellung von aminosäuren
US5487987A (en) 1993-09-16 1996-01-30 Purdue Research Foundation Synthesis of adipic acid from biomass-derived carbon sources
US5558656A (en) 1993-12-20 1996-09-24 The Procter & Gamble Company Sanitary napkin having an internal shaping component
DE69638080D1 (de) 1995-05-18 2009-12-31 Univ Stellenbosch Nukleinsäure für eine malat permease aus s.pombe kodierend und deren verwendungen
US5723639A (en) 1995-10-16 1998-03-03 University Of Chicago Esterification of fermentation-derived acids via pervaporation
DE19629372A1 (de) 1996-07-20 1998-01-22 Degussa Verfahren zur Herstellung von Malonsäure oder einem Salz derselben
AU733534B2 (en) 1996-11-13 2001-05-17 E.I. Du Pont De Nemours And Company Method for the production of 1,3-propanediol by recombinant microorganisms
SK285201B6 (sk) 1996-12-05 2006-08-03 Ajinomoto Co., Inc. Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7
US6117658A (en) 1997-02-13 2000-09-12 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units
US6087140A (en) 1997-02-19 2000-07-11 Wisconsin Alumni Research Foundation Microbial production of 1,2-propanediol from sugar
US6143538A (en) 1997-02-20 2000-11-07 The United States Of America As Represented By The United States Department Of Energy Fatty acyl-CoA reductase
US7125938B2 (en) 1997-03-11 2006-10-24 Carnegie Mellon University Atom or group transfer radical polymerization
US6566583B1 (en) 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
BE1011197A3 (fr) 1997-06-06 1999-06-01 Brussels Biotech En Abrege Bb Procede de purification d'acide lactique.
AU9402798A (en) 1997-09-19 1999-04-05 Ortho-Mcneil Pharmaceutical, Inc. Dna encoding a ras carboxyl-terminal processing protein
US6306636B1 (en) 1997-09-19 2001-10-23 Arch Development Corporation Nucleic acid segments encoding wheat acetyl-CoA carboxylase
US6229046B1 (en) 1997-10-14 2001-05-08 Cargill, Incorported Lactic acid processing methods arrangements and products
US6509156B1 (en) 1997-12-05 2003-01-21 Europaisches Laboratorium Fur Molekularoiologie (Embl) DNA cloning method relying on the E. coli recE/recT recombination system
KR100250830B1 (ko) 1997-12-09 2000-04-01 성재갑 자가분해에 의해 폴리하이드록시알킨산으로부터 광학활성을 가진 단량체 하이드록시카르복실산의 제조방법
US20030087381A1 (en) 1998-04-13 2003-05-08 University Of Georgia Research Foundation, Inc. Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals
JP4913929B2 (ja) 1998-06-12 2012-04-11 味の素株式会社 核酸系物質の製造法
ES2302386T3 (es) 1998-08-04 2008-07-01 Metabolix, Inc. Produccion de polihidroxialcanoatos a partir de polioles.
ATE319835T1 (de) 1998-08-18 2006-03-15 Metabolix Inc Transgene polyhydroxyalkanoat produzierende mikroben
JP4184606B2 (ja) 1998-09-04 2008-11-19 協和醗酵工業株式会社 新規遺伝子
RU2203269C2 (ru) 1998-10-30 2003-04-27 Каталитик Дистиллейшн Текнолоджиз Получение амидов и/или кислот из нитрилов
US6297319B1 (en) 1998-11-05 2001-10-02 Nippon Shokubai Co., Ltd. Water-absorbing agent and production process therefor
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
WO2000039287A2 (en) 1998-12-31 2000-07-06 Millennium Pharmaceuticals, Inc. A. fumigatus acetyl coenzyme-a carboxylase genes and polypeptides and uses thereof
US7217856B2 (en) 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
BRPI0009229B8 (pt) 1999-03-22 2021-05-25 Purac Biochem Bv processo de purificação de ácido láctico, em escala industrial.
AU3886000A (en) 1999-03-23 2000-10-09 Board Of Trustees Of Michigan State University Synthesis of 1,2,3,4-tetrahydroxybenzenes and 1,2,3-trihydroxybenzenes using myo-inositol-1-phosphate synthase and myo-inositol 2-dehydrogenase
AU4211600A (en) 1999-04-10 2000-11-14 Maxygen, Inc. Modified lipid production
US6355412B1 (en) 1999-07-09 2002-03-12 The European Molecular Biology Laboratory Methods and compositions for directed cloning and subcloning using homologous recombination
US6852517B1 (en) 1999-08-30 2005-02-08 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
EP1124979B1 (en) 1999-08-30 2006-08-30 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
US7033781B1 (en) 1999-09-29 2006-04-25 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
US20020102672A1 (en) 1999-10-04 2002-08-01 Joseph Mizrahi Process for producing a purified lactic acid solution
ATE319848T1 (de) 1999-10-25 2006-03-15 Kosan Biosciences Inc Herstellung von polyketiden
US6531291B1 (en) 1999-11-10 2003-03-11 The Trustees Of Columbia University In The City Of New York Antimicrobial activity of gemfibrozil and related compounds and derivatives and metabolites thereof
WO2001038284A1 (en) 1999-11-24 2001-05-31 Cargill Dow Llc Improved lactic acid processing; methods; arrangements; and, products
NL1013682C2 (nl) 1999-11-26 2001-05-30 Purac Biochem Bv Werkwijze en inrichting voor het zuiveren van een waterige oplossing van melkzuur.
US6613553B1 (en) 2000-02-04 2003-09-02 St. Jude Children's Research Hospital Enoyl reductases and methods of use thereof
RU2212447C2 (ru) 2000-04-26 2003-09-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Штамм escherichia coli - продуцент аминокислоты (варианты) и способ получения аминокислот (варианты)
US6998256B2 (en) 2000-04-28 2006-02-14 Kosan Biosciences, Inc. Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
US6586229B1 (en) 2000-06-01 2003-07-01 North Carolina State University Method for the production of ρ-Hydroxybenzoate in species of pseudomonas and agrobacterium
DE60120415T2 (de) 2000-07-21 2007-01-04 Metabolix, Inc., Cambridge Herstellung von polyhydroxyalkanoaten aus polyolen
CA2322105A1 (en) 2000-10-23 2002-04-23 Plant Bioscience Limited Antibiotic production (ii)
AU2002219818B2 (en) 2000-11-20 2007-08-16 Cargill, Incorporated 3-hydroxypropionic acid and other organic compounds
US6623944B2 (en) 2001-03-14 2003-09-23 Degussa Ag Process for preparation of D-pantothenic acid and/or salts thereof
MXPA03010183A (es) 2001-05-07 2004-03-16 Cargill Inc Proceso para preparar acidos carboxilicos y derivados de los mismos.
MY146503A (en) 2001-08-13 2012-08-15 Malaysian Palm Oil Board Method and compositions for the production of transgenic plants
US6723799B2 (en) 2001-08-24 2004-04-20 E I. Du Pont De Nemours And Company Acid-dyeable polymer compositions
JP4356454B2 (ja) 2001-10-23 2009-11-04 味の素株式会社 新規グルタミン酸受容体とその利用
US7256016B2 (en) 2001-11-02 2007-08-14 Rice University Recycling system for manipulation of intracellular NADH availability
AU2002357355A1 (en) 2001-12-18 2003-06-30 Metabolix, Inc. Methods of making intermediates from polyhydroxyalkanoates
ATE432338T1 (de) 2002-01-18 2009-06-15 Novozymes As Alanin-2,3-aminomutase
US6709919B2 (en) 2002-05-15 2004-03-23 Taiwan Semiconductor Manufacturing Company Method for making auto-self-aligned top electrodes for DRAM capacitors with improved capacitor-to-bit-line-contact overlay margin
US7314974B2 (en) 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
AU2003225644A1 (en) 2002-03-01 2003-09-16 Monsanto Technology Llc Wax ester synthase dna sequence, protein and uses thereof
CN1642897A (zh) 2002-03-25 2005-07-20 嘉吉有限公司 制造β－羟基羧酸衍生物的方法
EP2431475B1 (en) 2002-05-10 2019-07-10 Tepha, Inc. Bioabsorbable polymer containing 2-hydroxyacid monomers
EP1532516A4 (en) 2002-07-10 2007-05-23 Penn State Res Found Method for determining gene knockout strategies
US7826975B2 (en) 2002-07-10 2010-11-02 The Penn State Research Foundation Method for redesign of microbial production systems
AU2003205041A1 (en) 2002-07-12 2004-01-29 Ajinomoto Co., Inc. Method for producing target substance by fermentation
GB0218019D0 (en) 2002-08-05 2002-09-11 Ciba Spec Chem Water Treat Ltd Production of a fermentation product
US7371558B2 (en) 2002-10-04 2008-05-13 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
CN100381411C (zh) 2002-11-01 2008-04-16 嘉吉有限公司 制备1,3-丙二醇的方法
US20040152159A1 (en) 2002-11-06 2004-08-05 Causey Thomas B. Materials and methods for the efficient production of acetate and other products
WO2004052829A1 (ja) 2002-12-06 2004-06-24 Kaneka Corporation 光学活性３−ヒドロキシプロピオン酸エステル誘導体の製造法
EP2348107A3 (fr) 2003-02-18 2012-07-11 Metabolic Explorer Procédé de préparation de microorganismes évolués permettant la création ou la modification de voies métaboliques
US7141154B2 (en) 2003-03-06 2006-11-28 Uchicago Argonne Llc Single-stage separation and esterification of cation salt carboxylates using electrodeionization
ES2421138T3 (es) 2003-03-31 2013-08-29 University Of Bristol Nuevas aciltransferasas vegetales específicas para ácidos grasos poliinsaturados de cadena larga
DE10314618A1 (de) 2003-04-01 2004-10-14 Degussa Ag Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae
US20040225116A1 (en) 2003-05-08 2004-11-11 Payne Mark S. Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from comamonas testosteroni 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids
EP1654212B1 (en) 2003-06-26 2009-07-29 Novozymes A/S Process for separating and recovering 3-hydroxypropionic acid and acrylic acid
US7927794B2 (en) 2003-09-29 2011-04-19 The Regents Of The University Of California Methods for identifying a biosynthetic pathway gene product
FR2862068B1 (fr) 2003-11-06 2007-10-12 Metabolic Explorer Sa Souches de microorganismes optimisees pour des voies de biosyntheses consommatrices de nadph
US7326557B2 (en) 2003-11-14 2008-02-05 Rice University Increasing intracellular NADPH availability in E. coli
DK1706457T3 (da) 2003-12-04 2012-05-21 Novozymes As Fremstilling af 3-hydroxypropionsyre ved anvendelse af beta-alanin/pyruvataminotransferase
US7186214B2 (en) 2004-02-12 2007-03-06 Medtronic, Inc. Instruments and methods for accessing an anatomic space
EP1731604A4 (en) 2004-03-26 2007-04-04 Nippon Catalytic Chem Ind PROCESS FOR THE PREPARATION OF 1,3-PROPANEL AND / OR 3-HYDROXYPROPIONIC ACID
WO2005095320A1 (en) 2004-04-02 2005-10-13 Ciba Specialty Chemicals Water Treatments Limited Preparation of acrylic acid derivatives from alpha or beta-hydroxy carboxylic acids
US20070259863A1 (en) 2004-04-28 2007-11-08 Icos Corporation Arylphenylamino-,Arylphenylamide-, and Arylphenylether-Sulfide Derivatives
US20050272135A1 (en) 2004-06-02 2005-12-08 The University Of Chicago Processs for production and purification of fermentation derived organic acids
US7652167B2 (en) 2004-07-19 2010-01-26 Board Of Trustees Of Michigan State University Process for production of organic acid esters
AU2005266875B2 (en) 2004-07-23 2012-07-26 Acceleron Pharma Inc. ActRII receptor polypeptides, methods and compositions
US20090031453A1 (en) 2004-07-30 2009-01-29 Holly Jean Jessen Alanine 2, 3 aminomutases
US7148051B2 (en) 2004-08-16 2006-12-12 E. I. Du Pont De Nemours And Company Production of 3-hydroxycarboxylic acid using nitrilase
KR20070065870A (ko) 2004-09-17 2007-06-25 라이스 유니버시티 다량의 숙신산염을 생산하는 세균
US7987056B2 (en) 2004-09-20 2011-07-26 The Regents Of The University Of Colorado, A Body Corporate Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes
KR101340580B1 (ko) 2004-10-12 2013-12-11 보드 오브 트러스티즈 오브 미시건 스테이트 유니버시티 플로로글루시놀의 생합성 및 이로부터1,3-디하이드록시벤젠의 합성
AU2005295656B2 (en) 2004-10-14 2011-08-04 Carnegie Institution Of Washington Development of sensitive FRET sensors and methods of using the same
US7273746B2 (en) 2004-11-04 2007-09-25 E.I. Dupont De Nemours And Company Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
US7550286B2 (en) 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
DE102004062294A1 (de) 2004-12-23 2006-07-06 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen
TWI529181B (zh) 2005-02-28 2016-04-11 贏創德固賽有限責任公司 以可更新原料為基之吸水聚合物結構及其生產的方法
CA2603151A1 (en) 2005-03-30 2006-10-05 Jitao Zou Identification of a sterol acyltransferase gene
US7998713B2 (en) 2005-04-12 2011-08-16 E. I. Du Pont De Nemours And Company Treatment of biomass to obtain ethanol
US7524660B2 (en) 2005-05-05 2009-04-28 E.I. Du Pont De Nemours And Company Utilization of fructose in microbial production strains
WO2006125000A2 (en) 2005-05-19 2006-11-23 E.I. Du Pont De Nemours And Company Method for the production of resveratrol in a recombinant oleaginous microorganism
KR20080036608A (ko) 2005-07-18 2008-04-28 바스프 에스이 메티오닌 생산 재조합 미생물
US20090132178A1 (en) 2005-08-03 2009-05-21 Dharamsi Akil I Crystalline enoyl-(acyl-carrier-protein) Reductase from Heliobacter Pylori
EP1752532A1 (en) * 2005-08-09 2007-02-14 Helmholtz-Zentrum für Infektionsforschung GmbH Extracellular polyhydroxyalkanoates produced by genetically engineered microorganisms
US7846688B2 (en) 2005-08-15 2010-12-07 The Regents Of The University Of Colorado Broad host range vectors for shotgun and expression library cloning in Gram negative bacteria
AU2006287257A1 (en) 2005-09-09 2007-03-15 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
DE102005048818A1 (de) 2005-10-10 2007-04-12 Degussa Ag Mikrobiologische Herstellung von 3-Hydroxypropionsäure
WO2007047680A2 (en) 2005-10-14 2007-04-26 Cargill, Incorporated Increasing the activity of radical s-adenosyl methionine (sam) enzymes
NZ566406A (en) 2005-10-26 2012-04-27 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
JP5064761B2 (ja) 2005-12-21 2012-10-31 富士フイルム株式会社 ジエチレントリアミン型金属キレート構造を有する高級脂肪酸トリエステル及びアミド誘導体
US8535916B2 (en) 2006-02-13 2013-09-17 Ls9, Inc. Modified microorganisms and uses therefor
US20070219390A1 (en) 2006-03-15 2007-09-20 Battelle Memorial Institute Method and apparatus for conversion of beta-hydroxy carbonyl compounds
CN101473038B (zh) 2006-03-15 2014-05-28 Dsmip资产公司 含有多不饱和脂肪酸的植物种子油
US7687661B2 (en) 2006-03-15 2010-03-30 Battelle Memorial Institute Method for conversion of β-hydroxy carbonyl compounds
US7842485B2 (en) 2006-03-15 2010-11-30 The Regents Of The University Of Colorado Enhanced alcohol tolerant microorganism and methods of use thereof
KR20070096348A (ko) 2006-03-23 2007-10-02 주식회사 엘지화학 1,4―ｂｕｔａｎｅｄｉｏｌ〔１，４―ＢＤＯ〕생성능을가지는 변이체 및 이를 이용한 １，４―ＢＤＯ의 제조방법
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
CN101490241A (zh) * 2006-05-19 2009-07-22 Ls9公司 脂肪酸及其衍生物的制备
MX344588B (es) 2006-05-19 2016-12-20 Reg Life Sciences Llc Produccion de acidos grasos y derivados de los mismos.
KR101417146B1 (ko) 2006-05-26 2014-07-08 아미리스 인코퍼레이티드 이소프레노이드의 생산 방법
DE102006025821A1 (de) 2006-06-02 2007-12-06 Degussa Gmbh Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd
US20080103060A1 (en) 2006-08-08 2008-05-01 Regents Of The University Of Colorado Compositions and methods for chemical reporter vectors
DE102006039203B4 (de) 2006-08-22 2014-06-18 Evonik Degussa Gmbh Verfahren zur Herstellung von durch Kristallisation gereinigter Acrylsäure aus Hydroxypropionsäure sowie Vorrichtung dazu
US8906667B2 (en) 2006-08-29 2014-12-09 William Marsh Rice University Increasing NADPH-dependent products
BRPI0716212A2 (pt) 2006-08-30 2013-10-15 Cargill Inc Beta-alanina/alfa-cetoglutarato aminotransferase para produção de ácido 3-hidroxipropiônico
CA2663808A1 (en) 2006-09-18 2008-03-27 Qiang Hu Algal medium chain length fatty acids and hydrocarbons
US20100099910A1 (en) 2006-10-04 2010-04-22 Cargill Incorporated Carboxylic acids prepared using a salt-splitting process
EP2087096A4 (en) 2006-10-20 2009-11-25 Univ Arizona MODIFIED CYANOBACTERIA
US20100136640A1 (en) 2006-12-15 2010-06-03 Biofuelchem Co., Ltd. Enhanced butanol producing microorganisms and method for preparing butanol using the same
EP2126042A4 (en) 2007-01-12 2010-08-04 Univ Colorado Regents COMPOSITIONS AND METHODS FOR INCREASING TOLERANCE FOR THE PRODUCTION BY MICRO-ORGANISMS OF PRODUCED ORGANIC CHEMICALS
US8673601B2 (en) 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
US8329436B2 (en) 2007-02-09 2012-12-11 Zeachem, Inc. Method of making propanol and ethanol from plant material by biological conversion and gasification
US8110093B2 (en) 2007-03-14 2012-02-07 Ls9, Inc. Process for producing low molecular weight hydrocarbons from renewable resources
BRPI0809039A2 (pt) 2007-03-23 2014-09-16 Metabolic Explorer Sa Microorganismos metabolicamente projetados úteis para a produção de 1,2-propanodiol
EP2149608A4 (en) 2007-04-16 2013-02-20 Ajinomoto Kk PROCESS FOR PREPARING AN ORGANIC ACID
JP5449142B2 (ja) 2007-06-01 2014-03-19 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング メタクリル酸又はメタクリルエステルの製造方法
WO2008149951A1 (ja) 2007-06-06 2008-12-11 Kao Corporation 透明固形石鹸
US8198055B2 (en) 2007-06-08 2012-06-12 Coskata, Inc. Process for converting syngas to liquid products with microorganisms on two-layer membrane
WO2009006430A1 (en) 2007-06-29 2009-01-08 The Regents Of The University Of California Host cells and methods for producing fatty acid derived compounds
JP2010263790A (ja) 2007-09-04 2010-11-25 Ajinomoto Co Inc アミノ酸生産微生物及びアミノ酸の製造法
KR20090026230A (ko) 2007-09-09 2009-03-12 김건 임베디드 시스템의 범용 고속 실시간 모니터링 장치
WO2009036095A1 (en) 2007-09-10 2009-03-19 Joule Biotechnologies, Inc. Engineered light-harvesting organisms
JP2009067775A (ja) 2007-09-17 2009-04-02 Rohm & Haas Co ヒドロキシカルボン酸、またはその塩を、不飽和カルボン酸および／またはそのエステルに変換する方法
AU2008304180B2 (en) 2007-09-27 2014-02-27 Genomatica, Inc. Reduction of the toxic effect of impurities from raw materials by extractive fermentation
MX2010005061A (es) 2007-11-10 2010-09-09 Joule Unltd Inc Organismos hiperfotosinteticos.
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
US8518678B2 (en) 2007-12-21 2013-08-27 Butamax(Tm) Advanced Biofuels Llc Strain comprising increased expression of a CFA coding region for butanol production
US8183028B2 (en) 2007-12-21 2012-05-22 Ls9, Inc. Methods and compositions for producing olefins
WO2009089457A1 (en) 2008-01-11 2009-07-16 Novozymes A/S Methods for producing 3-hydroxypropionic acid and compounds thereof
CA2712779C (en) 2008-01-22 2021-03-16 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
WO2009111513A1 (en) 2008-03-03 2009-09-11 Joule Biotechnologies, Inc. Engineered co2 fixing microorganisms producing carbon-based products of interest
BRPI0909690A2 (pt) 2008-03-05 2019-02-26 Genomatica Inc organismos produtores de alcoóis primários
US8598378B2 (en) 2008-03-14 2013-12-03 University Of Hawaii Methods and compositions for extraction and transesterification of biomass components
CN101983239A (zh) 2008-03-28 2011-03-02 加利福尼亚大学董事会 使用聚酮化物合酶制备二元羧酸
TWI456949B (zh) 2008-04-30 2014-10-11 Thomson Licensing 閘口裝置及其使用方法
CN105483068A (zh) 2008-05-16 2016-04-13 Reg生命科学有限责任公司 产生碳氢化合物的方法和组合物
WO2009143401A2 (en) 2008-05-23 2009-11-26 E. I. Du Pont De Nemours And Company Dgat genes from oleaginous organisms for increased seed storage lipid production and altered fatty acid profiles in in oilseed plants
CA2723874A1 (en) 2008-06-04 2009-12-10 Butamaxtm Advanced Biofuels Llc Deletion mutants for the production of isobutanol
DE102008002309A1 (de) 2008-06-09 2009-12-10 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
WO2009151342A1 (en) 2008-06-09 2009-12-17 Lanzatech New Zealand Limited Production of butanediol by anaerobic microbial fermentation
DE102008002715A1 (de) 2008-06-27 2009-12-31 Evonik Röhm Gmbh 2-Hydroxyisobuttersäure produzierende rekombinante Zelle
US20110190513A1 (en) 2008-07-08 2011-08-04 Lynch Michael D Methods, compositions and systems for biosynthetic bio-production of 1,4-butanediol
AU2009273953B2 (en) 2008-07-23 2013-08-29 Opx Biotechnologies, Inc Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-HP)
US20100021978A1 (en) 2008-07-23 2010-01-28 Genomatica, Inc. Methods and organisms for production of 3-hydroxypropionic acid
US20110281314A1 (en) 2008-08-04 2011-11-17 Lynch Michael D Methods, systems and compositions related to microbial bio-production of butanol and/or isobutanol
US20160362710A9 (en) 2008-08-18 2016-12-15 REG Life Sciences, LLC Systems and methods for production of mixed fatty esters
EP2326709A4 (en) 2008-09-15 2013-01-23 Opx Biotechnologies Inc METHODS, SYSTEMS AND COMPOSITIONS RELATED TO REDUCED MICROBIAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID (3-HP) IN ALDEHYDMETABOLITE
BRPI0913818A2 (pt) 2008-10-03 2017-03-28 Agrisoma Biosciences Inc método de produção de plantas transgênicas, planta transgênica e método de produção de óleo
EP2352824B1 (en) 2008-10-07 2015-09-02 REG Life Sciences, LLC Method and compositions for producing fatty aldehydes
JP2012511910A (ja) 2008-12-12 2012-05-31 セレクション， エルエルシー 炭水化物原料からの二官能性アルカンの生物学的合成
US8835137B2 (en) 2008-12-23 2014-09-16 Matrix Genetics, Llc Modified photosynthetic microorganisms with reduced glycogen and their use in producing carbon-based products
CN110129296A (zh) 2008-12-23 2019-08-16 Reg生命科学有限责任公司 硫酯酶相关的方法和组合物
US20120094386A1 (en) 2009-03-11 2012-04-19 Sapphire Energy, Inc. Engineering salt tolerance in photosynthetic microorganisms
AU2010232533A1 (en) 2009-04-02 2011-10-13 University Of Florida Research Foundation, Inc. Engineering the pathway for succinate production
BRPI1014472A8 (pt) 2009-04-10 2015-12-08 Ls9 Inc Método para produzir um derivado de ácido graxo, microrganismo engenheirado geneticamente, derivado de ácido graxo e composição de biocombustível
US20110144377A1 (en) 2009-06-16 2011-06-16 E. I. Du Pont Nemours And Company Process for the biological production of 3-hydroxypropionic acid with high yield
WO2011008565A1 (en) 2009-06-29 2011-01-20 Synthetic Genomics, Inc. Acyl-acp thioesterase genes and uses therefor
CN102482692A (zh) 2009-07-01 2012-05-30 诺维信北美公司 用于分离和回收3-羟基丙酸的工艺
CA3056664A1 (en) 2009-09-25 2011-03-31 Alfred Gaertner Production of fatty acid derivatives in recombinant bacterial cells expressing an ester synthase variant
GB2487866A (en) 2009-09-27 2012-08-08 Opx Biotechnologies Inc Method for producing 3-Hydroxypropionic acid and other products
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
MX2012004291A (es) 2009-10-13 2012-08-17 Genomatica Inc Microorganismos para la produccion de 1,4-butanoidol, 4-hidroxibutanal, 4-hidroxibutiril-coa, putrescina y compuestos y metodos relacionados con los mismos.
CA2777903A1 (en) 2009-10-20 2011-04-28 Bayer Cropscience Nv Methods and means to alter lipid biosynthesis by targeting multiple enzymes to suborganelle domains
US20110124063A1 (en) 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Methods, Systems, and Compositions for Microbial Bio-Production of Biomolecules Using Syngas Components, or Sugars, as Feedstocks
CA2781400A1 (en) 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an organic acid and/or related chemicals
KR20120115500A (ko) 2009-11-23 2012-10-18 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 전해질 첨가를 동반한 추출성 발효를 사용해 부탄올을 제조하는 방법
CA2782690A1 (en) 2009-12-02 2011-06-09 Board Of Trustees Of Michigan State University Carboxylic acid recovery and methods related thereto
US20110183382A1 (en) 2009-12-15 2011-07-28 Qteros, Inc. Methods and compositions for producing chemical products from c. phytofermentans
US8530221B2 (en) 2010-01-14 2013-09-10 Ls9, Inc. Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells
GB2492256A (en) * 2010-01-27 2012-12-26 Opx Biotechnologies Inc Microorganism production of high-valve chemical products, and related compositions, methods and systems
CN101745245B (zh) 2010-02-05 2012-05-23 北京化工大学 一种多级逆流式旋转床反应精馏装置及其应用
WO2011100667A1 (en) 2010-02-14 2011-08-18 Ls9, Inc. Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols
ES2899431T3 (es) * 2010-08-06 2022-03-11 Melt&Marble Ab Métodos y productos para la producción de ésteres de cera
US10138504B2 (en) 2010-08-06 2018-11-27 Lallemand Hungary Liquidity Management Llc Production of malonyl-CoA derived products via anaerobic pathways
US8372610B2 (en) 2010-09-15 2013-02-12 Ls9, Inc. Production of odd chain fatty acid derivatives in recombinant microbial cells
KR20130123388A (ko) 2010-09-28 2013-11-12 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 폴리케타이드 신타제를 이용한 알파-올레핀의 제조
US20140148615A1 (en) 2010-10-18 2014-05-29 Zeachem, Inc. Recovery of organic acid using a complex extraction solvent
EP2643450A2 (en) 2010-11-22 2013-10-02 Novozymes, Inc. Compositions and methods for 3-hydroxypropionic acid production
BR112013012603A2 (pt) 2010-11-22 2016-08-09 Univ Florida Res Foudation Inc engenharia de bacillus coagulans termotolerante para a produção de ácido d(-)-láctico
US20140121118A1 (en) 2010-11-23 2014-05-01 Opx Biotechnologies, Inc. Methods, systems and compositions regarding multiplex construction protein amino-acid substitutions and identification of sequence-activity relationships, to provide gene replacement such as with tagged mutant genes, such as via efficient homologous recombination
EP2673369B1 (en) * 2011-02-07 2017-04-05 William Marsh Rice University Reverse beta oxidation pathway
US20140330032A1 (en) * 2011-03-22 2014-11-06 Michael D. Lynch Microbial production of chemical products and related compositions, methods and systems
KR20120108538A (ko) 2011-03-24 2012-10-05 삼성전자주식회사 말로닉 세미알데히드 환원 경로를 이용한 3-하이드록시프로피온산의 생산방법
WO2012135760A1 (en) 2011-03-30 2012-10-04 Ls9, Inc. Compositions comprising and methods for producing beta-hydroxy fatty acid esters
US20120264902A1 (en) 2011-04-18 2012-10-18 The Regents Of The University Of Colorado, A Body Corporate Methods, Systems and Compositions for Increased Microorganism Tolerance to and Production of 3-Hydroxypropionic Acid (3-HP)
WO2012177726A1 (en) 2011-06-22 2012-12-27 Genomatica, Inc. Microorganism for producing primary alcohols and related compounds and methods related thereto
KR101860442B1 (ko) 2011-06-27 2018-05-24 삼성전자주식회사 3-하이드록시프로피온산의 생산을 위한 유전자 조작
CN103813709A (zh) 2011-06-28 2014-05-21 布鲁克黑文科学联合会 具有增加的油含量的经修饰植物
WO2013018879A1 (ja) * 2011-08-04 2013-02-07 サントリーホールディングス株式会社 脂肪酸鎖長延長促進活性を有するタンパク質、これをコードする遺伝子及びその用途
JP2014528705A (ja) 2011-08-04 2014-10-30 ダニスコ・ユーエス・インク アセトアセチルＣｏＡシンターゼを用いるイソプレン、イソプレノイド前駆体、及びイソプレノイドの生産
CN103975070A (zh) 2011-09-27 2014-08-06 艾克森美孚研究与工程公司 酰基-酰基载体蛋白(acyl-acp)蜡酯合酶
US8790901B2 (en) 2011-12-14 2014-07-29 Pronutria, Inc. Microorganisms and methods for producing unsaturated fatty acids
WO2013126855A1 (en) 2012-02-23 2013-08-29 The Regents Of The University Of California Atp driven direct photosynthetic production of fuels and chemicals
MY181688A (en) 2012-04-02 2021-01-01 Genomatica Inc Improved production of fatty acid derivatives
KR20210095226A (ko) 2012-04-02 2021-07-30 게노마티카 인코포레이티드 Ｃａｒ 효소들 및 지방족 알코올들의 개선된 생산
US20130345470A1 (en) 2012-06-20 2013-12-26 Opx Biotechnologies, Inc. Purification of 3-Hydroxypropionic Acid from Crude Cell Broth and Production of Acrylamide
WO2013192451A1 (en) 2012-06-20 2013-12-27 Opx Biotechnologies, Inc. Dehydration of 3-hydroxypropionic acid to acrylic acid
CA2881666A1 (en) 2012-08-10 2014-02-13 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
CN104955944B (zh) 2012-09-14 2021-03-09 基因组股份公司 具有改善的酯合酶特性的酶变体
ES2600354T3 (es) 2013-01-16 2017-02-08 REG Life Sciences, LLC Acil-ACP reductasa con propiedades mejoradas
WO2014116754A1 (en) 2013-01-23 2014-07-31 Iowa State University Research Foundation, Inc. Materials and methods for characterizing and using kasiii for production of bi-functional fatty acids
BR112015023473B1 (pt) 2013-03-15 2023-04-11 Cargill, Incorporated Microrganismo geneticamente modificado e método de produzir um produto
US20150044746A1 (en) 2013-03-15 2015-02-12 Opx Biotechnologies, Inc. Method of enhanced bioproduction
WO2014146026A1 (en) 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Bioproduction of chemicals
BR112015023583A2 (pt) 2013-03-15 2017-08-22 Dow Global Technologies Llc Método para vaporização 3-hp a partir de uma solução, vapor, solução 3-hp condensada, composição, produto químico à jusante, produto de consumo, sistema para purificação de 3-hp, método para produzir uma solução de 3-hp, método para decompor a amônia de 3-hp (a3-hp) e método para decompor a3-hp
US10066245B2 (en) 2013-06-14 2018-09-04 Technical University Of Denmark Microbial production of 3-hydroxypropionic acid
BR112016001026A2 (pt) * 2013-07-19 2017-10-24 Cargill Inc organismo geneticamente modificado
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009529890A (ja) * 2006-03-15 2009-08-27 マーテック バイオサイエンシーズ コーポレーション Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法
JP2010527612A (ja) * 2007-05-22 2010-08-19 エルエス９・インコーポレイテッド 炭化水素産生遺伝子およびその使用方法
US20100274033A1 (en) * 2009-04-27 2010-10-28 Ls9, Inc. Production of fatty acid esters
JP2010259388A (ja) * 2009-05-08 2010-11-18 Toyota Motor Corp ブタノール生産能を有する組換え微生物及びブタノールの製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BMC BIOCHEMISTRY, 2011, VOL.12, NO.44, PP.1-16, JPN6019010879, ISSN: 0004140237 *

Also Published As

Publication number Publication date
BR112015002940A2 (pt) 2018-04-24
US10465213B2 (en) 2019-11-05
KR20150040359A (ko) 2015-04-14
SG11201501013PA (en) 2015-04-29
MX2015001780A (es) 2015-09-28
CA2881666A1 (en) 2014-02-13
EP2882843A1 (en) 2015-06-17
WO2014026162A1 (en) 2014-02-13
IN2015DN01858A (cg-RX-API-DMAC7.html) 2015-05-29
AU2013299414A1 (en) 2015-03-26
US20160340700A1 (en) 2016-11-24
EP2882843A4 (en) 2016-04-06
CN109182238A (zh) 2019-01-11
US20140051136A1 (en) 2014-02-20
CN104718282A (zh) 2015-06-17

Similar Documents

Publication Publication Date Title
US10465213B2 (en) Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP3022310B1 (en) Microorganisms and methods for the production of fatty acids and fatty acid derived products
JP2020103304A (ja) 合成代謝弁を用いた迅速かつ動的なフラックス制御のための組成物及び方法
US10982240B2 (en) Production of polyhydroxy alkanoates with a defined composition from an unrelated carbon source
US12129506B2 (en) Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP2993228A2 (en) Production of fatty acid esters
JP2017515480A (ja) 極長炭素鎖化合物を生物学的に産生するための方法
WO2013019647A1 (en) Production of fatty acids and derivatives thereof having improved aliphatic chain length and saturation characteristics
US20250059524A1 (en) Thioesterase variants having improved activity for the production of medium-chain fatty acid derivatives
JP2022520814A (ja) 逆グリオキシル酸短絡を通じたグリコール酸およびグリシンの生成のための微生物および方法
US8993281B2 (en) Genetically modified Acinetobacter hosts for lipid production
WO2018203076A1 (en) Modified microorganisms and methods for production of branched c5 carbon compounds
WO2015054138A1 (en) Improved fatty acid productivity
JP6486372B2 (ja) 改善されたアセチル−ＣｏＡカルボキシラーゼ変種
Dodelin Selection and Characterization of Escherichia coli Citrate Synthase Variants That Improve Biosynthesis of Products Derived From Acetyl-CoA
CA3109062A1 (en) Xylr mutant for improved xylose utilization or improved co-utilization of glucose and xylose

Legal Events

Date Code Title Description
A625 Written request for application examination (by other person)

Free format text: JAPANESE INTERMEDIATE CODE: A625

Effective date: 20160805

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20161219

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20161219

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20170118

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20170118

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170801

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20171020

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20171215

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180131

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180703

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180921

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20181203

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181221

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190402

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20191029