JP2014517842A5 - - Google Patents
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- JP2014517842A5 JP2014517842A5 JP2014512101A JP2014512101A JP2014517842A5 JP 2014517842 A5 JP2014517842 A5 JP 2014517842A5 JP 2014512101 A JP2014512101 A JP 2014512101A JP 2014512101 A JP2014512101 A JP 2014512101A JP 2014517842 A5 JP2014517842 A5 JP 2014517842A5
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- Prior art keywords
- cancer
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- pharmaceutically acceptable
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- 150000001875 compounds Chemical class 0.000 claims 8
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- 201000011510 cancer Diseases 0.000 claims 4
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- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
- 239000004474 valine Substances 0.000 claims 2
- AGGWFDNPHKLBBV-YUMQZZPRSA-N (2s)-2-[[(2s)-2-amino-3-methylbutanoyl]amino]-5-(carbamoylamino)pentanoic acid Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=O AGGWFDNPHKLBBV-YUMQZZPRSA-N 0.000 claims 1
- ALBODLTZUXKBGZ-JUUVMNCLSA-N (2s)-2-amino-3-phenylpropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 ALBODLTZUXKBGZ-JUUVMNCLSA-N 0.000 claims 1
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- OBTCMSPFOITUIJ-FSPLSTOPSA-N Val-Asp Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CC(O)=O OBTCMSPFOITUIJ-FSPLSTOPSA-N 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161490117P | 2011-05-26 | 2011-05-26 | |
| US61/490,117 | 2011-05-26 | ||
| PCT/US2012/039312 WO2012162482A1 (en) | 2011-05-26 | 2012-05-24 | Immunoconjugates, compositions containing them, and methods of making and use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017017666A Division JP6359133B2 (ja) | 2011-05-26 | 2017-02-02 | 免疫コンジュゲート、それらを含有する組成物、ならびに製造方法および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014517842A JP2014517842A (ja) | 2014-07-24 |
| JP2014517842A5 true JP2014517842A5 (enExample) | 2015-05-21 |
| JP6105566B2 JP6105566B2 (ja) | 2017-03-29 |
Family
ID=46172969
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512101A Expired - Fee Related JP6105566B2 (ja) | 2011-05-26 | 2012-05-24 | 免疫コンジュゲート、それらを含有する組成物、ならびに製造方法および使用方法 |
| JP2017017666A Expired - Fee Related JP6359133B2 (ja) | 2011-05-26 | 2017-02-02 | 免疫コンジュゲート、それらを含有する組成物、ならびに製造方法および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017017666A Expired - Fee Related JP6359133B2 (ja) | 2011-05-26 | 2017-02-02 | 免疫コンジュゲート、それらを含有する組成物、ならびに製造方法および使用方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8852599B2 (enExample) |
| EP (1) | EP2714092B1 (enExample) |
| JP (2) | JP6105566B2 (enExample) |
| KR (1) | KR102070464B1 (enExample) |
| CN (1) | CN103561772B (enExample) |
| AR (1) | AR086568A1 (enExample) |
| AU (1) | AU2012258750B2 (enExample) |
| BR (1) | BR112013029764A2 (enExample) |
| CA (1) | CA2837327C (enExample) |
| CL (1) | CL2013003393A1 (enExample) |
| CO (1) | CO6831975A2 (enExample) |
| EA (1) | EA024844B1 (enExample) |
| ES (1) | ES2814798T3 (enExample) |
| IL (1) | IL229477A (enExample) |
| MA (1) | MA35153B1 (enExample) |
| MX (1) | MX336806B (enExample) |
| PE (1) | PE20141480A1 (enExample) |
| PH (1) | PH12013502189A1 (enExample) |
| SG (1) | SG195011A1 (enExample) |
| TW (1) | TW201300401A (enExample) |
| UY (1) | UY34100A (enExample) |
| WO (1) | WO2012162482A1 (enExample) |
| ZA (2) | ZA201309669B (enExample) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008275985B2 (en) * | 2007-07-17 | 2013-09-19 | E. R. Squibb & Sons, L.L.C. | Monoclonal antibodies against Glypican-3 |
| EP3539982B1 (en) | 2011-12-23 | 2025-02-19 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
| KR20210132742A (ko) | 2012-12-21 | 2021-11-04 | 알트루바이오 인코퍼레이티드 | 친수성 자기-희생 링커 및 그것의 포합체 |
| US10233249B2 (en) | 2013-03-19 | 2019-03-19 | Beijing Shenogen Pharma Group Ltd. | Antibodies and methods for treating estrogen receptor-associated diseases |
| DK2991683T3 (da) | 2013-05-02 | 2019-11-04 | Glykos Finland Oy | Konjugater af et glykoprotein eller en glykan med en toksisk ladning |
| BR112016002829A2 (pt) | 2013-08-12 | 2017-09-19 | Genentech Inc | Composto e processo para preparar o composto de conjugado anticorpo-¿droga, composição farmacêutica, método de tratamento do câncer, kit para o tratamento do câncer, intermediário ligante¿-droga, porção e composto de porção droga de dímero cbi |
| JP6980384B2 (ja) | 2013-12-16 | 2021-12-15 | ジェネンテック， インコーポレイテッド | １−（クロロメチル）−２，３−ジヒドロ−１ｈ−ベンゾ［ｅ］インドール二量体抗体−薬物コンジュゲート化合物、並びに使用及び処置の方法 |
| SG11201605437YA (en) * | 2014-01-27 | 2016-08-30 | Pfizer | Bifunctional cytotoxic agents |
| SG11201607818WA (en) | 2014-03-20 | 2016-10-28 | Bristol Myers Squibb Co | Stabilized fibronectin based scaffold molecules |
| SMT202100146T1 (it) * | 2014-04-30 | 2021-05-07 | Pfizer | Coniugati di anticorpo anti-ptk7-farmaco |
| KR20170020868A (ko) | 2014-06-20 | 2017-02-24 | 바이오얼라이언스 씨.브이. | 항-폴레이트 수용체 알파 (fra) 항체-약물 컨쥬게이트 및 그것의 사용 방법 |
| WO2015196089A1 (en) * | 2014-06-20 | 2015-12-23 | Bioalliance C.V. | Anti-cd22 antibody-drug conjugates and methods of using thereof |
| US10973920B2 (en) | 2014-06-30 | 2021-04-13 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| GB201412658D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| ES2826566T3 (es) | 2014-11-21 | 2021-05-18 | Bristol Myers Squibb Co | Anticuerpos que comprenden regiones constantes pesadas modificadas |
| JP6805142B2 (ja) | 2014-11-21 | 2020-12-23 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｃｄ７３に対する抗体およびその使用 |
| JP6622814B2 (ja) | 2014-11-25 | 2019-12-18 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | イメージングのための新規ｐｄ−ｌ１結合ポリペプチド |
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