|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
US4671958A
(en)
|
1982-03-09 |
1987-06-09 |
Cytogen Corporation |
Antibody conjugates for the delivery of compounds to target sites
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US4970198A
(en)
|
1985-10-17 |
1990-11-13 |
American Cyanamid Company |
Antitumor antibiotics (LL-E33288 complex)
|
|
GB2183662B
(en)
|
1985-04-01 |
1989-01-25 |
Celltech Ltd |
Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
US5037651A
(en)
|
1987-01-30 |
1991-08-06 |
American Cyanamid Company |
Dihydro derivatives of LL-E33288 antibiotics
|
|
US5108912A
(en)
|
1987-01-30 |
1992-04-28 |
American Cyanamid Company |
Antitumor antibiotics (LL-E33288 complex)
|
|
US5079233A
(en)
|
1987-01-30 |
1992-01-07 |
American Cyanamid Company |
N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
|
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
|
US5053394A
(en)
|
1988-09-21 |
1991-10-01 |
American Cyanamid Company |
Targeted forms of methyltrithio antitumor agents
|
|
US5606040A
(en)
|
1987-10-30 |
1997-02-25 |
American Cyanamid Company |
Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
|
|
GB8809129D0
(en)
|
1988-04-18 |
1988-05-18 |
Celltech Ltd |
Recombinant dna methods vectors and host cells
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
ES2246502T3
(es)
|
1990-08-29 |
2006-02-16 |
Genpharm International, Inc. |
Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech, Inc., South San Francisco, Calif. |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
|
EP0590058B1
(en)
|
1991-06-14 |
2003-11-26 |
Genentech, Inc. |
HUMANIZED Heregulin ANTIBODy
|
|
GB9116610D0
(en)
|
1991-08-01 |
1991-09-18 |
Danbiosyst Uk |
Preparation of microparticles
|
|
CA2078539C
(en)
|
1991-09-18 |
2005-08-02 |
Kenya Shitara |
Process for producing humanized chimera antibody
|
|
US7744877B2
(en)
|
1992-11-13 |
2010-06-29 |
Biogen Idec Inc. |
Expression and use of anti-CD20 Antibodies
|
|
ATE139900T1
(de)
|
1992-11-13 |
1996-07-15 |
Idec Pharma Corp |
Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma
|
|
US5981568A
(en)
|
1993-01-28 |
1999-11-09 |
Neorx Corporation |
Therapeutic inhibitor of vascular smooth muscle cells
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
|
ZA955642B
(en)
|
1994-07-07 |
1997-05-06 |
Ortho Pharma Corp |
Lyophilized imaging agent formulation
|
|
US5663149A
(en)
|
1994-12-13 |
1997-09-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
|
|
WO1997026885A1
(en)
|
1996-01-23 |
1997-07-31 |
The General Hospital Corporation Doing Business As Massachusetts General Hospital |
Benzophenothiazine and benzoporphyrin dye combination photodynamic therapy of tumors
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
JP2002522063A
(ja)
|
1998-08-17 |
2002-07-23 |
アブジェニックス インコーポレイテッド |
増加した血清半減期を有する改変された分子の生成
|
|
WO2000053211A2
(en)
|
1999-03-09 |
2000-09-14 |
University Of Southern California |
Method of promoting myocyte proliferation and myocardial tissue repair
|
|
US6309633B1
(en)
|
1999-06-19 |
2001-10-30 |
Nobex Corporation |
Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
|
|
US6849425B1
(en)
|
1999-10-14 |
2005-02-01 |
Ixsys, Inc. |
Methods of optimizing antibody variable region binding affinity
|
|
WO2001062299A2
(en)
|
2000-02-28 |
2001-08-30 |
Shearwater Corporation |
Water-soluble polymer conjugates of artelinic acid
|
|
AU2002348477A1
(en)
|
2001-05-01 |
2002-12-23 |
The General Hospital Corporation |
Photoimmunotherapies for cancer using photosensitizer immunoconjugates and combination therapies
|
|
US7321026B2
(en)
|
2001-06-27 |
2008-01-22 |
Skytech Technology Limited |
Framework-patched immunoglobulins
|
|
US6997863B2
(en)
|
2001-07-25 |
2006-02-14 |
Triton Biosystems, Inc. |
Thermotherapy via targeted delivery of nanoscale magnetic particles
|
|
US7771951B2
(en)
|
2001-12-03 |
2010-08-10 |
Amgen Fremont Inc. |
Antibody categorization based on binding characteristics
|
|
JP2005533001A
(ja)
|
2002-03-04 |
2005-11-04 |
メディミューン，インコーポレーテッド |
インテグリンαｖβ３アンタゴニストを他の物質と併用投与する癌の予防または治療方法
|
|
GB0219776D0
(en)
|
2002-08-24 |
2002-10-02 |
Oxford Glycosciences Uk Ltd |
A protein involved in carcinoma
|
|
JP2006507256A
(ja)
|
2002-09-24 |
2006-03-02 |
ザ バーナム インスティチュート |
Ｅｐｈ受容体活性を調節する新規薬剤
|
|
US7619068B2
(en)
|
2003-05-09 |
2009-11-17 |
Diadexus, Inc. |
Ovr110 antibody compositions and methods of use
|
|
DK1675961T3
(da)
|
2003-10-24 |
2009-02-23 |
Oncalis Ag |
Fremgangsmåde til identifikation og/eller validering af receptortyrosinkinaseinhibitorer
|
|
NZ551180A
(en)
*
|
2004-06-01 |
2009-10-30 |
Genentech Inc |
Antibody drug conjugates and methods
|
|
AU2005277641A1
(en)
|
2004-08-16 |
2006-03-02 |
Medimmune, Llc |
Eph receptor Fc variants with enhanced antibody dependent cell-mediated cytotoxicity activity
|
|
US8222253B2
(en)
|
2004-10-23 |
2012-07-17 |
Case Western Reserve University |
Peptide and small molecule agonists of EphA and their uses
|
|
WO2006113546A2
(en)
|
2005-04-15 |
2006-10-26 |
Neogenix Oncology, Inc. |
Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers
|
|
KR20080080482A
(ko)
|
2005-09-07 |
2008-09-04 |
메디뮨 엘엘씨 |
독소가 컨쥬게이트된 ｅｐｈ 수용체 항체
|
|
NZ569236A
(en)
|
2005-12-08 |
2012-06-29 |
Medarex Inc |
Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and their use
|
|
WO2007080457A2
(en)
|
2005-12-30 |
2007-07-19 |
Institut Gustave Roussy |
Use of inhibitors of scinderin and/or of ephrin-a1 for treating tumors
|
|
TW200806685A
(en)
|
2006-02-21 |
2008-02-01 |
Wyeth Corp |
Processes for the convergent synthesis of calicheamicin derivatives
|
|
US8343461B2
(en)
|
2006-03-08 |
2013-01-01 |
Wake Forest University Health Sciences |
Molecular signature of cancer
|
|
WO2007145901A1
(en)
|
2006-06-06 |
2007-12-21 |
University Of Tennessee Research Foundation |
Compositions enriched in neoplastic stem cells and methods comprising same
|
|
EP3207941B3
(en)
|
2006-09-07 |
2020-08-19 |
Scott & White Memorial Hospital |
Methods and compositions based on diphtheria toxin-interleukin-3 conjugates
|
|
JP5697446B2
(ja)
|
2007-05-22 |
2015-04-08 |
ワイス・エルエルシー |
ヒドラジドを製造するための改善されたプロセス
|
|
WO2008149803A1
(ja)
|
2007-06-06 |
2008-12-11 |
The University Of Tokyo |
表面抗原マーカーを用いた急性リンパ性白血病における癌幹細胞の分離同定方法
|
|
CA2693144A1
(en)
|
2007-07-17 |
2009-01-22 |
The General Hospital Corporation |
Methods to identify and enrich for populations of ovarian cancer stem cells and somatic ovarian stem cells and uses thereof
|
|
WO2009043051A2
(en)
|
2007-09-27 |
2009-04-02 |
Biogen Idec Ma Inc. |
Cd23 binding molecules and methods of use thereof
|
|
WO2009070767A2
(en)
|
2007-11-28 |
2009-06-04 |
Whitehead Institute For Biomedical Research |
Systemic instigation systems to study tumor growth or metastasis
|
|
EP2229187A2
(en)
|
2007-11-30 |
2010-09-22 |
Bristol-Myers Squibb Company |
Monoclonal antibody partner molecule conjugates directed to protein tyrosine kinase 7 (ptk7)
|
|
WO2009116764A2
(ko)
|
2008-03-17 |
2009-09-24 |
연세대학교 산학협력단 |
Ptk7 단백질의 기능 저해를 통한 세포의 이동, 침윤 또는 혈관신생 억제제
|
|
KR101123130B1
(ko)
|
2008-03-17 |
2012-03-30 |
연세대학교 산학협력단 |
Ｐｔｋ７ 단백질의 기능 저해를 통한 세포의 이동, 침윤 또는 혈관신생 억제제
|
|
US8197809B2
(en)
|
2008-06-25 |
2012-06-12 |
Korea Research Institute Of Bioscience And Biotechnology |
CD9-specific human antibodies
|
|
JP2012514981A
(ja)
|
2009-01-12 |
2012-07-05 |
イントレクソン コーポレイション |
細胞コロニーのレーザーを介在したセクション化及び移行
|
|
US20110020221A1
(en)
|
2009-04-09 |
2011-01-27 |
The Johns Hopkins University |
Cancer stem cell expression patterns and compounds to target cancer stem cells
|
|
EP2380909A1
(en)
|
2010-04-26 |
2011-10-26 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
PTK-7 protein involved in breast cancer
|
|
US20130061342A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc. |
Identification and Enrichment of Cell Subpopulations
|
|
CA2809864A1
(en)
|
2010-09-03 |
2012-03-08 |
Stem Centrx, Inc. |
Identification and enrichment of cell subpopulations
|
|
WO2013119964A2
(en)
|
2012-02-08 |
2013-08-15 |
Stem Centrx, Inc. |
Identification and enrichment of cell subpopulations
|
|
US20130061340A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc. |
Identification and Enrichment of Cell Subpopulations
|
|
US9778264B2
(en)
|
2010-09-03 |
2017-10-03 |
Abbvie Stemcentrx Llc |
Identification and enrichment of cell subpopulations
|
|
EP2446895A1
(en)
|
2010-10-01 |
2012-05-02 |
Stemgen S.P.A. |
EPH receptor expression in tumor stem cells
|
|
CA2813411C
(en)
|
2010-11-05 |
2016-08-02 |
Rinat Neuroscience Corporation |
Engineered polypeptide conjugates and methods for making thereof using transglutaminase
|
|
SA112330278B1
(ar)
*
|
2011-02-18 |
2015-10-09 |
ستيم سينتركس، انك. |
مواد ضابطة جديدة وطرق للاستخدام
|
|
US8852599B2
(en)
*
|
2011-05-26 |
2014-10-07 |
Bristol-Myers Squibb Company |
Immunoconjugates, compositions for making them, and methods of making and use
|
|
SG11201401699WA
(en)
|
2011-11-11 |
2014-09-26 |
Rinat Neuroscience Corp |
Antibodies specific for trop-2 and their uses
|
|
EP2780039B9
(en)
*
|
2011-11-17 |
2018-04-18 |
Pfizer Inc |
Cytotoxic peptides and antibody drug conjugates thereof
|
|
EP3539982B1
(en)
|
2011-12-23 |
2025-02-19 |
Pfizer Inc. |
Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
|
|
CN107753954A
(zh)
*
|
2012-12-13 |
2018-03-06 |
免疫医疗公司 |
功效改进且毒性降低的抗体与sn‑38的免疫缀合物的剂量
|
|
JP2016531915A
(ja)
|
2013-08-28 |
2016-10-13 |
ステムセントリックス， インコーポレイテッド |
部位特異的抗体コンジュゲーション方法および組成物
|
|
US20190209704A1
(en)
|
2014-10-20 |
2019-07-11 |
Igenica Biotherapeutics, Inc. |
Novel antibody-drug conjugates and related compounds, compositions and methods of use
|