JP2013540749A5 - - Google Patents
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- Publication number
- JP2013540749A5 JP2013540749A5 JP2013529373A JP2013529373A JP2013540749A5 JP 2013540749 A5 JP2013540749 A5 JP 2013540749A5 JP 2013529373 A JP2013529373 A JP 2013529373A JP 2013529373 A JP2013529373 A JP 2013529373A JP 2013540749 A5 JP2013540749 A5 JP 2013540749A5
- Authority
- JP
- Japan
- Prior art keywords
- skin
- pain
- diseases
- disease
- expansion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010015150 Erythema Diseases 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 206010064930 age-related macular degeneration Diseases 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000036407 pain Effects 0.000 description 4
- 208000002874 Acne Vulgaris Diseases 0.000 description 3
- 206010000496 acne Diseases 0.000 description 3
- 231100000321 erythema Toxicity 0.000 description 3
- 208000008069 Geographic Atrophy Diseases 0.000 description 2
- 208000010412 Glaucoma Diseases 0.000 description 2
- 241001303601 Rosacea Species 0.000 description 2
- 206010042033 Stevens-Johnson syndrome Diseases 0.000 description 2
- 201000008937 atopic dermatitis Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 206010013663 drug dependence Diseases 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 201000004700 rosacea Diseases 0.000 description 2
- 208000011117 substance-related disease Diseases 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 description 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- 206010058019 Cancer Pain Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012434 Dermatitis allergic Diseases 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 1
- 206010012688 Diabetic retinal oedema Diseases 0.000 description 1
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010060800 Hot flush Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010022489 Insulin Resistance Diseases 0.000 description 1
- 208000033463 Ischaemic neuropathy Diseases 0.000 description 1
- 208000014692 Lyell syndrome Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 208000008238 Muscle Spasticity Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 206010028735 Nasal congestion Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010029240 Neuritis Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 description 1
- 206010061323 Optic neuropathy Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 231100000168 Stevens-Johnson syndrome Toxicity 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 206010044223 Toxic epidermal necrolysis Diseases 0.000 description 1
- 231100000087 Toxic epidermal necrolysis Toxicity 0.000 description 1
- 208000000208 Wet Macular Degeneration Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 201000011190 diabetic macular edema Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 208000013465 muscle pain Diseases 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 208000020911 optic nerve disease Diseases 0.000 description 1
- 238000011474 orchiectomy Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000008845 photoaging Effects 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 208000004644 retinal vein occlusion Diseases 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 208000018198 spasticity Diseases 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 208000009935 visceral pain Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38337010P | 2010-09-16 | 2010-09-16 | |
| US61/383,370 | 2010-09-16 | ||
| PCT/US2011/052004 WO2012037499A1 (en) | 2010-09-16 | 2011-09-16 | Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013540749A JP2013540749A (ja) | 2013-11-07 |
| JP2013540749A5 true JP2013540749A5 (enExample) | 2016-02-04 |
| JP6073229B2 JP6073229B2 (ja) | 2017-02-01 |
Family
ID=44675870
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013529371A Withdrawn JP2013537236A (ja) | 2010-09-16 | 2011-09-16 | 皮膚疾患及び状態を治療するための［３−（１−（１ｈ−イミダゾール４−イル）エチル−２−メチルフェニル］メタノールのエステル・プロドラッグ |
| JP2013529373A Active JP6073229B2 (ja) | 2010-09-16 | 2011-09-16 | ［３−（１−（１ｈ−イミダゾール−４−イル）エチル）−２−メチルフェニル］メタノールのエステル・プロドラッグ |
| JP2013529372A Active JP6045495B2 (ja) | 2010-09-16 | 2011-09-16 | 眼圧を低下させるための［３−（１−（１ｈ−イミダゾール−４−イル）エチル）−２−メチルフェニル］メタノールのエステル・プロドラッグ |
| JP2013529360A Withdrawn JP2013541527A (ja) | 2010-09-16 | 2011-09-16 | 網膜疾患を治療するための［３−（１−（１ｈ−イミダゾール４−イル）エチル）−２−メチルフェニル］メタノールのエステル・プロドラッグ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013529371A Withdrawn JP2013537236A (ja) | 2010-09-16 | 2011-09-16 | 皮膚疾患及び状態を治療するための［３−（１−（１ｈ−イミダゾール４−イル）エチル−２−メチルフェニル］メタノールのエステル・プロドラッグ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013529372A Active JP6045495B2 (ja) | 2010-09-16 | 2011-09-16 | 眼圧を低下させるための［３−（１−（１ｈ−イミダゾール−４−イル）エチル）−２−メチルフェニル］メタノールのエステル・プロドラッグ |
| JP2013529360A Withdrawn JP2013541527A (ja) | 2010-09-16 | 2011-09-16 | 網膜疾患を治療するための［３−（１−（１ｈ−イミダゾール４−イル）エチル）−２−メチルフェニル］メタノールのエステル・プロドラッグ |
Country Status (28)
| Country | Link |
|---|---|
| US (9) | US8653123B2 (enExample) |
| EP (13) | EP3078376B1 (enExample) |
| JP (4) | JP2013537236A (enExample) |
| KR (7) | KR101952457B1 (enExample) |
| CN (5) | CN105412092B (enExample) |
| AR (4) | AR083018A1 (enExample) |
| AU (4) | AU2011301856C1 (enExample) |
| BR (4) | BR112013006352A2 (enExample) |
| CA (8) | CA2812195A1 (enExample) |
| CL (4) | CL2013000735A1 (enExample) |
| CY (3) | CY1121024T1 (enExample) |
| DK (9) | DK2616069T3 (enExample) |
| ES (10) | ES2613509T3 (enExample) |
| HU (5) | HUE038698T2 (enExample) |
| IL (4) | IL225282A0 (enExample) |
| MX (4) | MX2013003009A (enExample) |
| MY (4) | MY173846A (enExample) |
| NZ (1) | NZ608751A (enExample) |
| PL (7) | PL3050563T3 (enExample) |
| PT (7) | PT3348264T (enExample) |
| RU (4) | RU2612351C2 (enExample) |
| SG (4) | SG188572A1 (enExample) |
| SI (5) | SI3348264T1 (enExample) |
| TR (1) | TR201909249T4 (enExample) |
| TW (4) | TWI591058B (enExample) |
| UA (1) | UA112973C2 (enExample) |
| WO (4) | WO2012037499A1 (enExample) |
| ZA (4) | ZA201302193B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012518007A (ja) | 2009-02-13 | 2012-08-09 | アラーガン インコーポレイテッド | （３‐（１‐（１ｈ‐イミダゾール‐４‐イル）エチル）‐２‐メチルフェニル）メタノールを含む医薬組成物 |
| KR101841442B1 (ko) | 2010-01-11 | 2018-03-23 | 오렉시젠 세러퓨틱스 인크. | 주우울증 환자들에 있어서 체중 감량 치료를 제공하는 방법 |
| US8653123B2 (en) * | 2010-09-16 | 2014-02-18 | Allergan, Inc. | Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating retinal diseases |
| WO2013016073A1 (en) * | 2011-07-22 | 2013-01-31 | Allergan, Inc. | Alpha-2 adrenergic modulators for treating visual disorders mediated by central visual projections from the eye |
| EP2782569A1 (en) | 2011-11-21 | 2014-10-01 | Allergan, Inc. | Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases |
| USD794650S1 (en) | 2014-11-28 | 2017-08-15 | Samsung Electronics Co., Ltd. | Display screen or portion thereof with a graphical user interface |
| CN108310442B (zh) * | 2017-01-17 | 2021-08-27 | 台北科技大学 | 眼科用组合物 |
| KR102050506B1 (ko) | 2017-06-20 | 2019-11-29 | 한국식품연구원 | 망막 질환 예방, 개선, 완화 또는 치료용 조성물 |
| CN108872431B (zh) * | 2018-07-09 | 2021-03-23 | 成都倍特药业股份有限公司 | 一种检测4-(1-(2,5-二甲基苯基)乙基)-1h-咪唑或/和其盐酸盐的方法 |
| CN112552314B (zh) * | 2018-08-24 | 2022-03-04 | 杭州阿诺生物医药科技有限公司 | Sting激动剂小分子抗肿瘤化合物及其应用 |
| AU2022258105A1 (en) * | 2021-04-16 | 2023-10-26 | Ads Therapeutics Llc | Alpha2 adrenergic agonist codrugs conjugated with muscarinic agonist drugs |
| KR20250141793A (ko) * | 2023-02-08 | 2025-09-29 | 보슈 롬 아일랜드 리미티드 | 시력을 개선시키기 위한 알파-2-아드레날린성 효능제 |
| WO2025179071A1 (en) * | 2024-02-20 | 2025-08-28 | Bausch + Lomb Ireland Limited | Sustained-release drug delivery compositions for treating ocular diseases |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0642332T3 (da) | 1992-05-13 | 1997-06-16 | Sandoz Ltd | Ophthalmiske præparater indeholdende cyclosporin |
| US5459133A (en) * | 1992-06-05 | 1995-10-17 | Telor Ophthalmic Pharmaceuticals, Inc. | Methods and products for treating presbyopia |
| JPH09505298A (ja) | 1993-11-15 | 1997-05-27 | シェーリング コーポレイション | Ｈ▲下３▼‐レセプターアンタゴニストとしてのフェニル‐アルキルイミダゾール |
| US5474979A (en) | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| EP0957073A1 (en) * | 1998-05-12 | 1999-11-17 | Schwarz Pharma Ag | Novel derivatives of 3,3-diphenylpropylamines |
| US20040214829A1 (en) * | 2000-07-14 | 2004-10-28 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| US20020198209A1 (en) | 2001-05-03 | 2002-12-26 | Allergan Sales Inc. | Compositions having enhanced pharmacokinetic characteristics |
| EA010392B1 (ru) * | 2003-05-27 | 2008-08-29 | Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик (С.К.Р.А.С.) | Производные имидазолов, способ их получения и их применение в качестве лекарственного средства |
| US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| CN1823518A (zh) * | 2003-07-14 | 2006-08-23 | 皇家飞利浦电子股份有限公司 | 投影设备 |
| CA2538445A1 (en) | 2003-09-12 | 2005-04-21 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
| US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
| US20050244463A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| MXPA06013649A (es) | 2004-05-25 | 2007-07-09 | Sansrosa Pharmaceutical Dev In | Compuestos, formulaciones, y metodos para tratar o prevenir desordenes inflamatorios de la piel. |
| US20050277584A1 (en) | 2004-06-09 | 2005-12-15 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
| CN101031549A (zh) * | 2004-09-24 | 2007-09-05 | 阿勒根公司 | 作为特异性α2肾上腺素能激动剂的4－（苯甲基和取代苯甲基）－咪唑－2－硫酮 |
| US7931909B2 (en) | 2005-05-10 | 2011-04-26 | Allergan, Inc. | Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates |
| US7297679B2 (en) | 2005-07-13 | 2007-11-20 | Allergan, Inc. | Cyclosporin compositions |
| US20070015691A1 (en) | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
| US20070082070A1 (en) * | 2005-10-11 | 2007-04-12 | Stookey Evangeline L | Treating skin disorders |
| US7902247B2 (en) | 2008-01-09 | 2011-03-08 | Allergan, Inc. | Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors |
| AU2010210513A1 (en) | 2009-02-06 | 2011-09-01 | Allergan, Inc. | Pyridine compounds as subtype selective modulators of alpha2B and/or alpha 2C adrenergic receptors |
| JP2012518007A (ja) * | 2009-02-13 | 2012-08-09 | アラーガン インコーポレイテッド | （３‐（１‐（１ｈ‐イミダゾール‐４‐イル）エチル）‐２‐メチルフェニル）メタノールを含む医薬組成物 |
| US8394800B2 (en) * | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
| US8653123B2 (en) * | 2010-09-16 | 2014-02-18 | Allergan, Inc. | Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating retinal diseases |
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2011
- 2011-09-15 US US13/233,382 patent/US8653123B2/en active Active
- 2011-09-15 US US13/233,844 patent/US8501796B2/en active Active
- 2011-09-15 US US13/233,665 patent/US8492422B2/en active Active
- 2011-09-15 US US13/233,891 patent/US8492557B2/en active Active
- 2011-09-16 DK DK11760963.6T patent/DK2616069T3/en active
- 2011-09-16 EP EP16161921.8A patent/EP3078376B1/en active Active
- 2011-09-16 AR ARP110103390A patent/AR083018A1/es unknown
- 2011-09-16 CN CN201510767798.7A patent/CN105412092B/zh active Active
- 2011-09-16 ES ES11760963.6T patent/ES2613509T3/es active Active
- 2011-09-16 AU AU2011301856A patent/AU2011301856C1/en active Active
- 2011-09-16 MX MX2013003009A patent/MX2013003009A/es active IP Right Grant
- 2011-09-16 MX MX2013003004A patent/MX2013003004A/es active IP Right Grant
- 2011-09-16 CA CA2812195A patent/CA2812195A1/en not_active Abandoned
- 2011-09-16 PT PT181601741T patent/PT3348264T/pt unknown
- 2011-09-16 CA CA3116249A patent/CA3116249A1/en active Pending
- 2011-09-16 SI SI201131857T patent/SI3348264T1/sl unknown
- 2011-09-16 AU AU2011301932A patent/AU2011301932C1/en active Active
- 2011-09-16 PL PL16161920T patent/PL3050563T3/pl unknown
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- 2011-09-16 SI SI201131868T patent/SI3338777T1/sl unknown
- 2011-09-16 JP JP2013529371A patent/JP2013537236A/ja not_active Withdrawn
- 2011-09-16 AR ARP110103391A patent/AR083019A1/es unknown
- 2011-09-16 RU RU2013116541A patent/RU2612351C2/ru active
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- 2011-09-16 SI SI201131819T patent/SI3050564T1/sl unknown
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- 2011-09-16 MY MYPI2013000907A patent/MY173846A/en unknown
- 2011-09-16 DK DK16161920.0T patent/DK3050563T3/en active
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- 2011-09-16 JP JP2013529373A patent/JP6073229B2/ja active Active
- 2011-09-16 ES ES18160174T patent/ES2781681T3/es active Active
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- 2011-09-16 ES ES16161922.6T patent/ES2684055T3/es active Active
- 2011-09-16 MY MYPI2013000931A patent/MY168763A/en unknown
- 2011-09-16 KR KR1020137009505A patent/KR20140005154A/ko not_active Withdrawn
- 2011-09-16 CA CA3079450A patent/CA3079450A1/en active Pending
- 2011-09-16 JP JP2013529372A patent/JP6045495B2/ja active Active
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- 2011-09-16 HU HUE16161920A patent/HUE038698T2/hu unknown
- 2011-09-16 WO PCT/US2011/052004 patent/WO2012037499A1/en not_active Ceased
- 2011-09-16 TW TW100133491A patent/TWI591058B/zh active
- 2011-09-16 EP EP18157147.2A patent/EP3338777B1/en active Active
- 2011-09-16 SI SI201131550T patent/SI3053576T1/sl unknown
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- 2011-09-16 EP EP19194325.7A patent/EP3636263B1/en active Active
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- 2011-09-16 SG SG2013019575A patent/SG188572A1/en unknown
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- 2011-09-16 BR BR112013006362A patent/BR112013006362A2/pt not_active IP Right Cessation
- 2011-09-16 DK DK16161922.6T patent/DK3053576T3/en active
- 2011-09-16 CA CA3077732A patent/CA3077732A1/en active Pending
- 2011-09-16 EP EP16161920.0A patent/EP3050563B1/en active Active
- 2011-09-16 HU HUE16161922A patent/HUE039090T2/hu unknown
- 2011-09-16 WO PCT/US2011/051990 patent/WO2012037490A1/en not_active Ceased
- 2011-09-16 CA CA3122745A patent/CA3122745A1/en active Pending
- 2011-09-16 RU RU2013116403/15A patent/RU2013116403A/ru not_active Application Discontinuation
- 2011-09-16 ES ES16161920.0T patent/ES2687420T3/es active Active
- 2011-09-16 EP EP11760958.6A patent/EP2616066B1/en active Active
- 2011-09-16 PT PT117609636T patent/PT2616069T/pt unknown
- 2011-09-16 HU HUE18157147A patent/HUE048725T2/hu unknown
- 2011-09-16 KR KR1020137009503A patent/KR101840501B1/ko active Active
- 2011-09-16 DK DK18160174.1T patent/DK3348264T3/da active
- 2011-09-16 EP EP11760962.8A patent/EP2616068B1/en active Active
- 2011-09-16 RU RU2013116405/15A patent/RU2013116405A/ru unknown
- 2011-09-16 MX MX2013003002A patent/MX2013003002A/es active IP Right Grant
- 2011-09-16 CN CN201180053895XA patent/CN103200942A/zh active Pending
- 2011-09-16 DK DK19194325.7T patent/DK3636263T3/da active
- 2011-09-16 KR KR1020207011231A patent/KR102139905B1/ko active Active
- 2011-09-16 EP EP11760963.6A patent/EP2616069B1/en active Active
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