JP2013515038A5

JP2013515038A5 -

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Publication number: JP2013515038A5
Authority: JP; Japan
Prior art keywords: phenyl; chloro; methoxy; dihydro; alkyl
Prior art date: 2010-12-21
Legal status : Granted

Application number

JP2012545293A

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English (en)

Japanese (ja)

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JP2013515038A (ja

JP5542962B2 (ja

Filing date

2010-12-21

Publication date

2014-04-24

2010-12-21 Application filed filed Critical

2010-12-21 Priority claimed from PCT/EP2010/070364 external-priority patent/WO2011076786A1/en

2013-05-02 Publication of JP2013515038A publication Critical patent/JP2013515038A/ja

2014-04-24 Publication of JP2013515038A5 publication Critical patent/JP2013515038A5/ja

2014-07-09 Application granted granted Critical

2014-07-09 Publication of JP5542962B2 publication Critical patent/JP5542962B2/ja

Status Expired - Fee Related legal-status Critical Current

2030-12-21 Anticipated expiration legal-status Critical

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229910052757 nitrogen Inorganic materials 0.000 claims description 38
125000001424 substituent group Chemical group 0.000 claims description 38
125000000623 heterocyclic group Chemical group 0.000 claims description 25
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
125000005842 heteroatom Chemical group 0.000 claims description 14
229910052760 oxygen Inorganic materials 0.000 claims description 11
229910052717 sulfur Inorganic materials 0.000 claims description 11
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
125000005843 halogen group Chemical group 0.000 claims description 9
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 6
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 5
125000001475 halogen functional group Chemical group 0.000 claims description 4
ZHCAAFJSYLFLPX-UHFFFAOYSA-N nitrocyclohexatriene Chemical group [O-][N+](=O)C1=CC=C=C[CH]1 ZHCAAFJSYLFLPX-UHFFFAOYSA-N 0.000 claims description 4
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 38
-1 (4-chloro-2-methylaminomethyl-phenyl) -2- (4-dimethylamino-phenyl) -6-methoxy-1,4-dihydro-2H -Isoquinolin-3-one Chemical compound 0.000 claims 32
150000001875 compounds Chemical class 0.000 claims 31
150000003839 salts Chemical class 0.000 claims 20
229910052736 halogen Inorganic materials 0.000 claims 18
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 16
150000002367 halogens Chemical class 0.000 claims 15
125000004093 cyano group Chemical group *C#N 0.000 claims 13
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 12
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 11
125000003118 aryl group Chemical group 0.000 claims 10
125000004356 hydroxy functional group Chemical group O* 0.000 claims 9
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 9
201000010099 disease Diseases 0.000 claims 8
208000035475 disorder Diseases 0.000 claims 8
SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 7
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical compound C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 claims 5
VDBNYAPERZTOOF-UHFFFAOYSA-N isoquinolin-1(2H)-one Chemical compound C1=CC=C2C(=O)NC=CC2=C1 VDBNYAPERZTOOF-UHFFFAOYSA-N 0.000 claims 5
206010028980 Neoplasm Diseases 0.000 claims 4
125000003545 alkoxy group Chemical group 0.000 claims 4
230000002062 proliferating effect Effects 0.000 claims 4
VRHFNFAYNMYVRL-DFUCFPRFSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)C(O)=O)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)C(O)=O)=CC=C(Cl)C=C1 VRHFNFAYNMYVRL-DFUCFPRFSA-N 0.000 claims 3
125000001309 chloro group Chemical group Cl* 0.000 claims 3
CLRSLRWKONPSRQ-CPOWQTMSSA-N (1s)-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl-[[4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl]methyl]amino]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)CC2CCC(CC2)N2CC(=O)N(C)CC2)=CC=C(Cl)C=C1 CLRSLRWKONPSRQ-CPOWQTMSSA-N 0.000 claims 2
125000004070 6 membered heterocyclic group Chemical group 0.000 claims 2
LALBEQAKZKSMAL-BYIWRISSSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-(ethylamino)ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(C(C)NCC)=CC=C1N1C(=O)CC2=CC(OC)=C(O[C@H](C)CC)C=C2C1C1=CC=C(Cl)C=C1 LALBEQAKZKSMAL-BYIWRISSSA-N 0.000 claims 2
BZZYIHQWCXHSMZ-FMSKOOSDSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)NCC2)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)NCC2)=CC=C(Cl)C=C1 BZZYIHQWCXHSMZ-FMSKOOSDSA-N 0.000 claims 2
VZDNISKFMYZWGF-YFMCWZQFSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=NC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=NC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)=CC=C(Cl)C=C1 VZDNISKFMYZWGF-YFMCWZQFSA-N 0.000 claims 2
MTVMVQKGJODTNB-TWCVDLNQSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2N=CC(=NC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)C2)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2N=CC(=NC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)C2)=CC=C(Cl)C=C1 MTVMVQKGJODTNB-TWCVDLNQSA-N 0.000 claims 2
VTLCXFTWJRIHPW-JUPNEIPRSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC2CCC2)OC)C=2C=NC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC2CCC2)OC)C=2C=NC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)=CC=C(Cl)C=C1 VTLCXFTWJRIHPW-JUPNEIPRSA-N 0.000 claims 2
CLRSLRWKONPSRQ-VKGCBGSESA-N C1=2C=C(OC(C)C)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)C1C1=CC=C(Cl)C=C1 Chemical compound C1=2C=C(OC(C)C)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)C1C1=CC=C(Cl)C=C1 CLRSLRWKONPSRQ-VKGCBGSESA-N 0.000 claims 2
102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 claims 2
108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 claims 2
102000017274 MDM4 Human genes 0.000 claims 2
108050005300 MDM4 Proteins 0.000 claims 2
IXFIHZIZFSCBSU-GYNNIAEXSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(C)C)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(C)C)CC1 IXFIHZIZFSCBSU-GYNNIAEXSA-N 0.000 claims 2
NKIPMVCPPOTZLF-TWZRQJNISA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N)CC1 NKIPMVCPPOTZLF-TWZRQJNISA-N 0.000 claims 2
CUTQVOMRGYKGPV-XPTYZIKRSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(C)=O)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(C)=O)CC1 CUTQVOMRGYKGPV-XPTYZIKRSA-N 0.000 claims 2
239000013543 active substance Substances 0.000 claims 2
201000011510 cancer Diseases 0.000 claims 2
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
239000003814 drug Substances 0.000 claims 2
230000000694 effects Effects 0.000 claims 2
230000001404 mediated effect Effects 0.000 claims 2
229920006395 saturated elastomer Polymers 0.000 claims 2
238000006467 substitution reaction Methods 0.000 claims 2
FSLIGGSDKPKMAE-HHHXNRCGSA-N (1r)-1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C)=CC=C(Cl)C=C1 FSLIGGSDKPKMAE-HHHXNRCGSA-N 0.000 claims 1
ULWYHYVMAQFGPV-MUUNZHRXSA-N (1r)-1-(4-chlorophenyl)-7-cyclobutyloxy-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@H]2N(C(=O)CC=3C=C(C(=CC=32)OC2CCC2)OC)C=2C=CC(=CC=2)N(C)C)=CC=C(Cl)C=C1 ULWYHYVMAQFGPV-MUUNZHRXSA-N 0.000 claims 1
WFSJVHLKSNYJNJ-KWMCUTETSA-N (1r)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C1=CC=C(N(C)C)C=C1 WFSJVHLKSNYJNJ-KWMCUTETSA-N 0.000 claims 1
GYPIVOQVWAXHTL-QKUPIINXSA-N (1r)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(1r)-1-[4-(dimethylamino)piperidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@H](C)C2=CC=C(C=C2)N2[C@@H](C=3C=C(C(=CC=3CC2=O)OC)O[C@H](C)CC)C=2C=CC(Cl)=CC=2)CCC(N(C)C)CC1 GYPIVOQVWAXHTL-QKUPIINXSA-N 0.000 claims 1
GYPIVOQVWAXHTL-SERWZODPSA-N (1r)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(1s)-1-[4-(dimethylamino)piperidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@@H](C)C2=CC=C(C=C2)N2[C@@H](C=3C=C(C(=CC=3CC2=O)OC)O[C@H](C)CC)C=2C=CC(Cl)=CC=2)CCC(N(C)C)CC1 GYPIVOQVWAXHTL-SERWZODPSA-N 0.000 claims 1
NQEKLQPGKRJSLR-PLTNMMHCSA-N (1r)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclopropylmethyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N(C)CC1CC1 NQEKLQPGKRJSLR-PLTNMMHCSA-N 0.000 claims 1
GQUCZUQLQVPONT-XGCWNURASA-N (1r)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C1=CC=C(OC)C=C1 GQUCZUQLQVPONT-XGCWNURASA-N 0.000 claims 1
SSACIXCQKGESKK-LDLUVENISA-N (1r)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(2-oxoazetidin-1-yl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N1CCC1=O SSACIXCQKGESKK-LDLUVENISA-N 0.000 claims 1
RNOXGLRIZIHGIA-DHYKOVJISA-N (1r)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N(C)CC1=CC=NC=C1 RNOXGLRIZIHGIA-DHYKOVJISA-N 0.000 claims 1
GQUCZUQLQVPONT-CBZJRKILSA-N (1r)-7-[(2s)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@@H](C)CC)C=1C=CC(Cl)=CC=1)C1=CC=C(OC)C=C1 GQUCZUQLQVPONT-CBZJRKILSA-N 0.000 claims 1
BCXOYMISBMICAY-ZNTKNIQHSA-N (1r,3r)-3-amino-n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-ethylcyclopentane-1-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)[C@@H]1CC[C@@H](N)C1 BCXOYMISBMICAY-ZNTKNIQHSA-N 0.000 claims 1
PHQMADNKFUIKQR-NSNZTIKBSA-N (1r,3r)-n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-3-(dimethylamino)-n-ethylcyclopentane-1-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)[C@@H]1CC[C@@H](N(C)C)C1 PHQMADNKFUIKQR-NSNZTIKBSA-N 0.000 claims 1
FSLIGGSDKPKMAE-MHZLTWQESA-N (1s)-1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C)=CC=C(Cl)C=C1 FSLIGGSDKPKMAE-MHZLTWQESA-N 0.000 claims 1
AZTLSCFOQHSCPJ-LJAQVGFWSA-N (1s)-1-(4-chlorophenyl)-2-[4-(imidazol-1-ylmethyl)phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(CN3C=NC=C3)=CC=2)=CC=C(Cl)C=C1 AZTLSCFOQHSCPJ-LJAQVGFWSA-N 0.000 claims 1
QBSUFBUZLULMMR-NBLPZQPVSA-N (1s)-1-(4-chlorophenyl)-2-[4-[(1r)-1-[4-(2-hydroxyethyl)-2-oxopiperazin-1-yl]ethyl]phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@@H](C)N2C(CN(CCO)CC2)=O)=CC=C(Cl)C=C1 QBSUFBUZLULMMR-NBLPZQPVSA-N 0.000 claims 1
QBSUFBUZLULMMR-KATKFWMUSA-N (1s)-1-(4-chlorophenyl)-2-[4-[(1s)-1-[4-(2-hydroxyethyl)-2-oxopiperazin-1-yl]ethyl]phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@H](C)N2C(CN(CCO)CC2)=O)=CC=C(Cl)C=C1 QBSUFBUZLULMMR-KATKFWMUSA-N 0.000 claims 1
YJNAVDANBICIEK-IYXVLPAFSA-N (1s)-1-(4-chlorophenyl)-2-[4-[1-[4-(dimethylamino)piperidin-1-yl]-1-oxopropan-2-yl]phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)C(C)C(=O)N2CCC(CC2)N(C)C)=CC=C(Cl)C=C1 YJNAVDANBICIEK-IYXVLPAFSA-N 0.000 claims 1
FOWSNFVTTAEKAG-KMXYMDJGSA-N (1s)-1-(4-chlorophenyl)-2-[4-[1-[4-(dimethylamino)piperidin-1-yl]propan-2-yl]phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)C(C)CN2CCC(CC2)N(C)C)=CC=C(Cl)C=C1 FOWSNFVTTAEKAG-KMXYMDJGSA-N 0.000 claims 1
USHZDANZDYMQEF-IAOIYQAASA-N (1s)-1-(4-chlorophenyl)-2-[4-[[3-hydroxy-3-(hydroxymethyl)cyclobutyl]methyl-methylamino]phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)CC2CC(O)(CO)C2)=CC=C(Cl)C=C1 USHZDANZDYMQEF-IAOIYQAASA-N 0.000 claims 1
RZUHCUIVYJGOIV-RXQDXVOQSA-N (1s)-1-(4-chlorophenyl)-2-[6-[(3-hydroxycyclobutyl)methyl-methylamino]pyridin-3-yl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=NC(=CC=2)N(C)CC2CC(O)C2)=CC=C(Cl)C=C1 RZUHCUIVYJGOIV-RXQDXVOQSA-N 0.000 claims 1
AJYCGDGWEQCZPL-QJWGWKRISA-N (1s)-1-(4-chlorophenyl)-6-methoxy-2-[4-[(1r)-1-(2-oxopiperazin-1-yl)ethyl]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@@H](C)N2C(CNCC2)=O)=CC=C(Cl)C=C1 AJYCGDGWEQCZPL-QJWGWKRISA-N 0.000 claims 1
DQYUFTJKOQNYEW-HUBRWUETSA-N (1s)-1-(4-chlorophenyl)-6-methoxy-2-[4-[(1s)-1-(2-oxo-4-propan-2-ylpiperazin-1-yl)ethyl]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@H](C)N2C(CN(CC2)C(C)C)=O)=CC=C(Cl)C=C1 DQYUFTJKOQNYEW-HUBRWUETSA-N 0.000 claims 1
AJYCGDGWEQCZPL-GEFUHLBYSA-N (1s)-1-(4-chlorophenyl)-6-methoxy-2-[4-[(1s)-1-(2-oxopiperazin-1-yl)ethyl]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@H](C)N2C(CNCC2)=O)=CC=C(Cl)C=C1 AJYCGDGWEQCZPL-GEFUHLBYSA-N 0.000 claims 1
QLSBFLWZNCSXDA-MNAQKMTRSA-N (1s)-1-(4-chlorophenyl)-6-methoxy-2-[4-[(1s)-1-(4-methyl-2-oxopiperazin-1-yl)ethyl]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@H](C)N2C(CN(C)CC2)=O)=CC=C(Cl)C=C1 QLSBFLWZNCSXDA-MNAQKMTRSA-N 0.000 claims 1
PQUNQVFGYCPRQR-MNAQKMTRSA-N (1s)-1-(4-chlorophenyl)-6-methoxy-2-[4-[(1s)-1-(4-methyl-3-oxopiperazin-1-yl)ethyl]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@H](C)N2CC(=O)N(C)CC2)=CC=C(Cl)C=C1 PQUNQVFGYCPRQR-MNAQKMTRSA-N 0.000 claims 1
IOKRPXZSYFUMSP-MNAQKMTRSA-N (1s)-1-(4-chlorophenyl)-6-methoxy-2-[4-[(1s)-1-(4-methylsulfonyl-2-oxopiperazin-1-yl)ethyl]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@H](C)N2C(CN(CC2)S(C)(=O)=O)=O)=CC=C(Cl)C=C1 IOKRPXZSYFUMSP-MNAQKMTRSA-N 0.000 claims 1
AJYCGDGWEQCZPL-NIWHYCETSA-N (1s)-1-(4-chlorophenyl)-6-methoxy-2-[4-[1-(2-oxopiperazin-1-yl)ethyl]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)C(C)N2C(CNCC2)=O)=CC=C(Cl)C=C1 AJYCGDGWEQCZPL-NIWHYCETSA-N 0.000 claims 1
GHKUPLWFZHRXGD-YCUNKVRLSA-N (1s)-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(oxan-2-ylmethyl)amino]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)CC2OCCCC2)=CC=C(Cl)C=C1 GHKUPLWFZHRXGD-YCUNKVRLSA-N 0.000 claims 1
DWGTWZMNZJYAPW-WYYRYWFOSA-N (1s)-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(piperidin-2-ylmethyl)amino]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)CC2NCCCC2)=CC=C(Cl)C=C1 DWGTWZMNZJYAPW-WYYRYWFOSA-N 0.000 claims 1
ILNPXKPIIRUOJG-YTTGMZPUSA-N (1s)-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(piperidin-4-ylmethyl)amino]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)CC2CCNCC2)=CC=C(Cl)C=C1 ILNPXKPIIRUOJG-YTTGMZPUSA-N 0.000 claims 1
BACZWYQYWBLTRA-QTEAWJPNSA-N (1s)-1-(4-chlorophenyl)-6-methoxy-2-[6-[(1r)-1-(2-oxopiperazin-1-yl)ethyl]pyridin-3-yl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=NC(=CC=2)[C@@H](C)N2C(CNCC2)=O)=CC=C(Cl)C=C1 BACZWYQYWBLTRA-QTEAWJPNSA-N 0.000 claims 1
BACZWYQYWBLTRA-ADSBAMQRSA-N (1s)-1-(4-chlorophenyl)-6-methoxy-2-[6-[(1s)-1-(2-oxopiperazin-1-yl)ethyl]pyridin-3-yl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=NC(=CC=2)[C@H](C)N2C(CNCC2)=O)=CC=C(Cl)C=C1 BACZWYQYWBLTRA-ADSBAMQRSA-N 0.000 claims 1
ULWYHYVMAQFGPV-NDEPHWFRSA-N (1s)-1-(4-chlorophenyl)-7-cyclobutyloxy-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC2CCC2)OC)C=2C=CC(=CC=2)N(C)C)=CC=C(Cl)C=C1 ULWYHYVMAQFGPV-NDEPHWFRSA-N 0.000 claims 1
RYRUZBGIQCZGLT-MHZLTWQESA-N (1s)-2-[4-(5-amino-1h-pyrazol-4-yl)phenyl]-1-(4-chlorophenyl)-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)C=2C(=NNC=2)N)=CC=C(Cl)C=C1 RYRUZBGIQCZGLT-MHZLTWQESA-N 0.000 claims 1
NWEHVDGEHGVRRN-VTLMBFNKSA-N (1s)-2-[4-[(1s)-1-(4-acetyl-2-oxopiperazin-1-yl)ethyl]phenyl]-1-(4-chlorophenyl)-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@H](C)N2C(CN(CC2)C(C)=O)=O)=CC=C(Cl)C=C1 NWEHVDGEHGVRRN-VTLMBFNKSA-N 0.000 claims 1
JVNRCKRWFKVINQ-KATKFWMUSA-N (1s)-2-[4-[(1s)-1-(4-acetylpiperazin-1-yl)ethyl]phenyl]-1-(4-chlorophenyl)-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@H](C)N2CCN(CC2)C(C)=O)=CC=C(Cl)C=C1 JVNRCKRWFKVINQ-KATKFWMUSA-N 0.000 claims 1
RYYSFDSEVYTZFY-XIFFEERXSA-N (1s)-2-[4-[1-(4-acetylpiperazin-1-yl)cyclopropyl]phenyl]-1-(4-chlorophenyl)-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)C2(CC2)N2CCN(CC2)C(C)=O)=CC=C(Cl)C=C1 RYYSFDSEVYTZFY-XIFFEERXSA-N 0.000 claims 1
WFSJVHLKSNYJNJ-WRHNGFHOSA-N (1s)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C1=CC=C(N(C)C)C=C1 WFSJVHLKSNYJNJ-WRHNGFHOSA-N 0.000 claims 1
GYPIVOQVWAXHTL-KOOBERTFSA-N (1s)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(1r)-1-[4-(dimethylamino)piperidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@H](C)C2=CC=C(C=C2)N2[C@H](C=3C=C(C(=CC=3CC2=O)OC)O[C@H](C)CC)C=2C=CC(Cl)=CC=2)CCC(N(C)C)CC1 GYPIVOQVWAXHTL-KOOBERTFSA-N 0.000 claims 1
GYPIVOQVWAXHTL-CQEVQQNYSA-N (1s)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(1s)-1-[4-(dimethylamino)piperidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@@H](C)C2=CC=C(C=C2)N2[C@H](C=3C=C(C(=CC=3CC2=O)OC)O[C@H](C)CC)C=2C=CC(Cl)=CC=2)CCC(N(C)C)CC1 GYPIVOQVWAXHTL-CQEVQQNYSA-N 0.000 claims 1
NQEKLQPGKRJSLR-QJWGWKRISA-N (1s)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclopropylmethyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N(C)CC1CC1 NQEKLQPGKRJSLR-QJWGWKRISA-N 0.000 claims 1
GQUCZUQLQVPONT-CRYYWNKWSA-N (1s)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C1=CC=C(OC)C=C1 GQUCZUQLQVPONT-CRYYWNKWSA-N 0.000 claims 1
SSACIXCQKGESKK-LBEKAKSKSA-N (1s)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(2-oxoazetidin-1-yl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N1CCC1=O SSACIXCQKGESKK-LBEKAKSKSA-N 0.000 claims 1
RNOXGLRIZIHGIA-NBLPZQPVSA-N (1s)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N(C)CC1=CC=NC=C1 RNOXGLRIZIHGIA-NBLPZQPVSA-N 0.000 claims 1
GQUCZUQLQVPONT-SOKVYYICSA-N (1s)-7-[(2s)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@@H](C)CC)C=1C=CC(Cl)=CC=1)C1=CC=C(OC)C=C1 GQUCZUQLQVPONT-SOKVYYICSA-N 0.000 claims 1
BCXOYMISBMICAY-OMUAQUALSA-N (1s,3r)-3-amino-n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-ethylcyclopentane-1-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)[C@H]1CC[C@@H](N)C1 BCXOYMISBMICAY-OMUAQUALSA-N 0.000 claims 1
OBJVMDJHVUAQEF-IWNCIYCBSA-N (2r)-1-[(1s)-1-[4-[(1s)-1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-methylpyrrolidine-2-carboxamide Chemical compound CNC(=O)[C@H]1CCCN1[C@@H](C)C1=CC=C(N2C(CC3=CC(OC)=C(OC(C)C)C=C3[C@@H]2C=2C=CC(Cl)=CC=2)=O)C=C1 OBJVMDJHVUAQEF-IWNCIYCBSA-N 0.000 claims 1
HFUSQVKFLQGXMK-DKZLWGIFSA-N (2r,4s)-1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]benzoyl]-4-hydroxy-n-methylpyrrolidine-2-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(=O)N1C[C@@H](O)C[C@@H]1C(=O)NC HFUSQVKFLQGXMK-DKZLWGIFSA-N 0.000 claims 1
RCDSYFUKEHHTPW-LFBYOOETSA-N (2s)-1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]benzoyl]-n-methylpyrrolidine-2-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(=O)N1CCC[C@H]1C(=O)NC RCDSYFUKEHHTPW-LFBYOOETSA-N 0.000 claims 1
HFUSQVKFLQGXMK-YWDHBOEBSA-N (2s,4r)-1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]benzoyl]-4-hydroxy-n-methylpyrrolidine-2-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(=O)N1C[C@H](O)C[C@H]1C(=O)NC HFUSQVKFLQGXMK-YWDHBOEBSA-N 0.000 claims 1
125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 1
FZKBZCFTYLNIFX-UHFFFAOYSA-N 1-(3,4-difluorophenyl)-6,7-diethoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C=CC(OC)=CC=2)C1C1=CC=C(F)C(F)=C1 FZKBZCFTYLNIFX-UHFFFAOYSA-N 0.000 claims 1
ZXLRWOYXAXGZPV-WPUOIDIFSA-N 1-(3-amino-4-chlorophenyl)-7-[(2r)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=C(N)C(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 ZXLRWOYXAXGZPV-WPUOIDIFSA-N 0.000 claims 1
OGTOZCFDMLTYHX-KUFXBUICSA-N 1-(4-bromophenyl)-7-[(2r)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Br)=CC=2)N1C1=CC=C(N(C)C)C=C1 OGTOZCFDMLTYHX-KUFXBUICSA-N 0.000 claims 1
UDPFMWYRHQYYLF-UHFFFAOYSA-N 1-(4-chloro-2-fluorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC(C)C)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1F UDPFMWYRHQYYLF-UHFFFAOYSA-N 0.000 claims 1
HLONYRUIEVMDPJ-UHFFFAOYSA-N 1-(4-chloro-3-fluorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC(C)C)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C(F)=C1 HLONYRUIEVMDPJ-UHFFFAOYSA-N 0.000 claims 1
PGUOKEYICAUTBP-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[2-[3-(dimethylamino)propoxy]-4-methylphenyl]-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC(C)=CC=2)OCCCN(C)C)C1C1=CC=C(Cl)C=C1 PGUOKEYICAUTBP-UHFFFAOYSA-N 0.000 claims 1
NMJHGIDODUOMLE-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(3,5-dimethyl-1h-pyrazol-4-yl)phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC(C)C)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)C2=C(NN=C2C)C)C1C1=CC=C(Cl)C=C1 NMJHGIDODUOMLE-UHFFFAOYSA-N 0.000 claims 1
FHXWTQWJNIXVBV-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)-2-methoxyphenyl]-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC(=CC=2)N(C)C)OC)C1C1=CC=C(Cl)C=C1 FHXWTQWJNIXVBV-UHFFFAOYSA-N 0.000 claims 1
BPWAPUPQIZNSRV-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 BPWAPUPQIZNSRV-UHFFFAOYSA-N 0.000 claims 1
WEDPUWJGRDSVPL-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6,7-dimethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 WEDPUWJGRDSVPL-UHFFFAOYSA-N 0.000 claims 1
MJQBZQBEBGQIEG-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-(2,2,2-trifluoroethoxy)-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC(F)(F)F)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 MJQBZQBEBGQIEG-UHFFFAOYSA-N 0.000 claims 1
GSTLLKPMOMAOIQ-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-(2-methoxyethoxy)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(OCCOC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 GSTLLKPMOMAOIQ-UHFFFAOYSA-N 0.000 claims 1
AFKBYFBZERAVKG-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-(2-methylpropoxy)-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC(C)C)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 AFKBYFBZERAVKG-UHFFFAOYSA-N 0.000 claims 1
DNAMNZQWOGRYCT-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-(3-methoxypropoxy)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(OCCCOC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 DNAMNZQWOGRYCT-UHFFFAOYSA-N 0.000 claims 1
FUMYFPXFOSIDCI-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-(4-methylpent-4-en-2-yloxy)-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC(C)CC(C)=C)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 FUMYFPXFOSIDCI-UHFFFAOYSA-N 0.000 claims 1
ZPMQDCONNXLXCJ-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-(oxetan-2-ylmethoxy)-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC3OCC3)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 ZPMQDCONNXLXCJ-UHFFFAOYSA-N 0.000 claims 1
KLDRBTPRFBFGBX-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-(pyridin-4-ylmethoxy)-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC=3C=CN=CC=3)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 KLDRBTPRFBFGBX-UHFFFAOYSA-N 0.000 claims 1
WTYSVHLBGIOLTB-KUFXBUICSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-[(2r)-1-methoxypropan-2-yl]oxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)COC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 WTYSVHLBGIOLTB-KUFXBUICSA-N 0.000 claims 1
OULQWIAPTHWKSL-KUFXBUICSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-[(2r)-2-methoxypropoxy]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(OC[C@@H](C)OC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 OULQWIAPTHWKSL-KUFXBUICSA-N 0.000 claims 1
AHLQVYPGRFWKEP-CTLOQAHHSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-[[(2s)-oxolan-2-yl]methoxy]-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC[C@H]3OCCC3)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 AHLQVYPGRFWKEP-CTLOQAHHSA-N 0.000 claims 1
BCHLWBWRWJVGGJ-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-pent-4-en-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC(C)CC=C)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 BCHLWBWRWJVGGJ-UHFFFAOYSA-N 0.000 claims 1
XOCXCMLBORSZSK-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-pentan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(OC(C)CCC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 XOCXCMLBORSZSK-UHFFFAOYSA-N 0.000 claims 1
PULCHMQIYUDZIG-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-pentan-3-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(OC(CC)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 PULCHMQIYUDZIG-UHFFFAOYSA-N 0.000 claims 1
UMLOCQSZKXBPOL-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-phenylmethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC=3C=CC=CC=3)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 UMLOCQSZKXBPOL-UHFFFAOYSA-N 0.000 claims 1
FSLIGGSDKPKMAE-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC(C)C)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 FSLIGGSDKPKMAE-UHFFFAOYSA-N 0.000 claims 1
CMXYTBQSVPKNHM-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-propoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(OCCC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 CMXYTBQSVPKNHM-UHFFFAOYSA-N 0.000 claims 1
HSRNZQACGHQPIE-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-7-ethoxy-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(OCC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 HSRNZQACGHQPIE-UHFFFAOYSA-N 0.000 claims 1
FJWBIEUUUDYGBA-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-7-(pentan-3-ylamino)-1,4-dihydroisoquinolin-3-one Chemical compound C12=CC(NC(CC)CC)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 FJWBIEUUUDYGBA-UHFFFAOYSA-N 0.000 claims 1
PCLOGHHCVDXJJD-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-7-(propan-2-ylamino)-1,4-dihydroisoquinolin-3-one Chemical compound C12=CC(NC(C)C)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 PCLOGHHCVDXJJD-UHFFFAOYSA-N 0.000 claims 1
UYYSHKZIVFJVPH-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-7-(propylamino)-1,4-dihydroisoquinolin-3-one Chemical compound C12=CC(NCCC)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 UYYSHKZIVFJVPH-UHFFFAOYSA-N 0.000 claims 1
CAGZMCSXFPQMPM-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-7-[propan-2-yl(propyl)amino]-1,4-dihydroisoquinolin-3-one Chemical compound C12=CC(N(C(C)C)CCC)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 CAGZMCSXFPQMPM-UHFFFAOYSA-N 0.000 claims 1
AEBFAPAVYRWBDH-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[6-(3,5-dimethyl-1h-pyrazol-4-yl)pyridin-3-yl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC(C)C)C(OC)=CC=2CC(=O)N(C=2C=NC(=CC=2)C2=C(NN=C2C)C)C1C1=CC=C(Cl)C=C1 AEBFAPAVYRWBDH-UHFFFAOYSA-N 0.000 claims 1
CWXTXDKUPCJBQS-UHFFFAOYSA-N 1-(4-chlorophenyl)-6,7-diethoxy-2-(2-methoxy-4-morpholin-4-ylphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC(=CC=2)N2CCOCC2)OC)C1C1=CC=C(Cl)C=C1 CWXTXDKUPCJBQS-UHFFFAOYSA-N 0.000 claims 1
PKHHCVHLUFBEFF-UHFFFAOYSA-N 1-(4-chlorophenyl)-6,7-diethoxy-2-(4-morpholin-4-ylphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N2CCOCC2)C1C1=CC=C(Cl)C=C1 PKHHCVHLUFBEFF-UHFFFAOYSA-N 0.000 claims 1
SQAKBXSTDPKODN-UHFFFAOYSA-N 1-(4-chlorophenyl)-6,7-diethoxy-2-(5-methylpyridin-2-yl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2N=CC(C)=CC=2)C1C1=CC=C(Cl)C=C1 SQAKBXSTDPKODN-UHFFFAOYSA-N 0.000 claims 1
WIWMZSAAQAMQTG-UHFFFAOYSA-N 1-(4-chlorophenyl)-6,7-diethoxy-2-(6-methylpyridin-3-yl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C=NC(C)=CC=2)C1C1=CC=C(Cl)C=C1 WIWMZSAAQAMQTG-UHFFFAOYSA-N 0.000 claims 1
ZMSGLSMERZOMKO-UHFFFAOYSA-N 1-(4-chlorophenyl)-6,7-diethoxy-2-[4-methyl-2-(2-morpholin-4-ylethoxy)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC(C)=CC=2)OCCN2CCOCC2)C1C1=CC=C(Cl)C=C1 ZMSGLSMERZOMKO-UHFFFAOYSA-N 0.000 claims 1
FOCZOWVAISYOAB-UHFFFAOYSA-N 1-(4-chlorophenyl)-6,7-diethoxy-2-[4-methyl-2-(2h-tetrazol-5-ylmethoxy)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC(C)=CC=2)OCC2=NNN=N2)C1C1=CC=C(Cl)C=C1 FOCZOWVAISYOAB-UHFFFAOYSA-N 0.000 claims 1
KBSIRPIXPFGKMT-UHFFFAOYSA-N 1-(4-chlorophenyl)-6,7-diethoxy-2-[4-methyl-2-(3-morpholin-4-ylpropoxy)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC(C)=CC=2)OCCCN2CCOCC2)C1C1=CC=C(Cl)C=C1 KBSIRPIXPFGKMT-UHFFFAOYSA-N 0.000 claims 1
WXMVKMFCLIZMNL-UHFFFAOYSA-N 1-(4-chlorophenyl)-6,7-diethoxy-2-[4-methyl-2-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC(C)=CC=2)OCCN2CCN(C)CC2)C1C1=CC=C(Cl)C=C1 WXMVKMFCLIZMNL-UHFFFAOYSA-N 0.000 claims 1
JNSSEIKGGGQQBI-UHFFFAOYSA-N 1-(4-chlorophenyl)-6,7-diethoxy-2-[4-methyl-2-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC(C)=CC=2)OCCCN2CCN(C)CC2)C1C1=CC=C(Cl)C=C1 JNSSEIKGGGQQBI-UHFFFAOYSA-N 0.000 claims 1
HJDSASIKOIQSGQ-UHFFFAOYSA-N 1-(4-chlorophenyl)-6-(2-hydroxyethoxy)-7-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OCCO)=C(OC)C=C2C1C1=CC=C(Cl)C=C1 HJDSASIKOIQSGQ-UHFFFAOYSA-N 0.000 claims 1
QHOYODBKPXEUAV-UHFFFAOYSA-N 1-(4-chlorophenyl)-6-[2-(dimethylamino)ethoxy]-7-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OCCN(C)C)=C(OC)C=C2C1C1=CC=C(Cl)C=C1 QHOYODBKPXEUAV-UHFFFAOYSA-N 0.000 claims 1
FNLUMOZKSOMRTF-UHFFFAOYSA-N 1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-7-(2-methylpropoxy)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OCC(C)C)C=C2C1C1=CC=C(Cl)C=C1 FNLUMOZKSOMRTF-UHFFFAOYSA-N 0.000 claims 1
MEOLYVIICVDCSX-UHFFFAOYSA-N 1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-7-(3-methylbutan-2-yloxy)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OC(C)C(C)C)C=C2C1C1=CC=C(Cl)C=C1 MEOLYVIICVDCSX-UHFFFAOYSA-N 0.000 claims 1
BVPATVBIZGJIPL-UHFFFAOYSA-N 1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-7-pentan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(OC(C)CCC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 BVPATVBIZGJIPL-UHFFFAOYSA-N 0.000 claims 1
HPJLGAGUWJWCID-UHFFFAOYSA-N 1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-7-pentan-3-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(OC(CC)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 HPJLGAGUWJWCID-UHFFFAOYSA-N 0.000 claims 1
NOYJBYLOPGFUMF-UHFFFAOYSA-N 1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-7-propoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(OCCC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 NOYJBYLOPGFUMF-UHFFFAOYSA-N 0.000 claims 1
SQWPLSPYBVNLKM-UHFFFAOYSA-N 1-(4-chlorophenyl)-6-methoxy-2-[4-(2-oxoimidazolidin-1-yl)phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC(C)C)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N2C(NCC2)=O)C1C1=CC=C(Cl)C=C1 SQWPLSPYBVNLKM-UHFFFAOYSA-N 0.000 claims 1
OGUYBZHIFQYIPZ-UHFFFAOYSA-N 1-(4-chlorophenyl)-6-methoxy-2-[4-(2-oxopyrrolidin-1-yl)phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC(C)C)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N2C(CCC2)=O)C1C1=CC=C(Cl)C=C1 OGUYBZHIFQYIPZ-UHFFFAOYSA-N 0.000 claims 1
MCOYACBVYSBVJR-UHFFFAOYSA-N 1-(4-chlorophenyl)-6-methoxy-2-[4-(methylamino)phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(NC)=CC=C1N1C(=O)CC2=CC(OC)=C(OC(C)C)C=C2C1C1=CC=C(Cl)C=C1 MCOYACBVYSBVJR-UHFFFAOYSA-N 0.000 claims 1
JKTNIMGVOFAZKR-UHFFFAOYSA-N 1-(4-chlorophenyl)-6-methoxy-2-[4-methyl-2-(1,3-thiazol-5-ylmethoxy)phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC(C)C)C(OC)=CC=2CC(=O)N(C=2C(=CC(C)=CC=2)OCC=2SC=NC=2)C1C1=CC=C(Cl)C=C1 JKTNIMGVOFAZKR-UHFFFAOYSA-N 0.000 claims 1
CUCNRDAHGLBNKB-UHFFFAOYSA-N 1-(4-chlorophenyl)-6-methoxy-2-[4-methyl-2-(2h-tetrazol-5-ylmethoxy)phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC(C)C)C(OC)=CC=2CC(=O)N(C=2C(=CC(C)=CC=2)OCC2=NNN=N2)C1C1=CC=C(Cl)C=C1 CUCNRDAHGLBNKB-UHFFFAOYSA-N 0.000 claims 1
UZSHTXKYSDUANM-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(2,2-difluoroethoxy)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC(F)F)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 UZSHTXKYSDUANM-UHFFFAOYSA-N 0.000 claims 1
PQRDPICAUPSZKB-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(2-methylpropylamino)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C12=CC(NCC(C)C)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 PQRDPICAUPSZKB-UHFFFAOYSA-N 0.000 claims 1
XIFUESQBHWSTEF-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(3-hydroxypropoxy)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OCCCO)C=C2C1C1=CC=C(Cl)C=C1 XIFUESQBHWSTEF-UHFFFAOYSA-N 0.000 claims 1
YKRSWOUYXGPSCT-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(cyclobutylamino)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C=1C=C(N2C(CC3=CC=C(NC4CCC4)C=C3C2C=2C=CC(Cl)=CC=2)=O)C=CC=1N(C)CC1=CC=NC=C1 YKRSWOUYXGPSCT-UHFFFAOYSA-N 0.000 claims 1
MNXIAQJQLKUHMT-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(cyclobutylmethoxy)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC3CCC3)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 MNXIAQJQLKUHMT-UHFFFAOYSA-N 0.000 claims 1
FIHFZSXLPIOQNI-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(cyclohexylamino)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C=1C=C(N2C(CC3=CC=C(NC4CCCCC4)C=C3C2C=2C=CC(Cl)=CC=2)=O)C=CC=1N(C)CC1=CC=NC=C1 FIHFZSXLPIOQNI-UHFFFAOYSA-N 0.000 claims 1
BFNILMPGIUYSPN-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(cyclohexylmethoxy)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC3CCCCC3)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 BFNILMPGIUYSPN-UHFFFAOYSA-N 0.000 claims 1
GUPCNWDNDIASEG-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(cyclohexylmethylamino)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C=1C=C(N2C(CC3=CC=C(NCC4CCCCC4)C=C3C2C=2C=CC(Cl)=CC=2)=O)C=CC=1N(C)CC1=CC=NC=C1 GUPCNWDNDIASEG-UHFFFAOYSA-N 0.000 claims 1
OLNXCSXGQSVVIF-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(cyclopentylamino)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C=1C=C(N2C(CC3=CC=C(NC4CCCC4)C=C3C2C=2C=CC(Cl)=CC=2)=O)C=CC=1N(C)CC1=CC=NC=C1 OLNXCSXGQSVVIF-UHFFFAOYSA-N 0.000 claims 1
POYZJZSLAYEYHR-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(cyclopentylmethoxy)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC3CCCC3)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 POYZJZSLAYEYHR-UHFFFAOYSA-N 0.000 claims 1
FFVFJJBZJBHZIM-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(cyclopentylmethylamino)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C=1C=C(N2C(CC3=CC=C(NCC4CCCC4)C=C3C2C=2C=CC(Cl)=CC=2)=O)C=CC=1N(C)CC1=CC=NC=C1 FFVFJJBZJBHZIM-UHFFFAOYSA-N 0.000 claims 1
HZSHEMIOIFAKHG-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(cyclopropylmethoxy)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC3CC3)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 HZSHEMIOIFAKHG-UHFFFAOYSA-N 0.000 claims 1
LNCPCAOWLSIUHY-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(cyclopropylmethoxy)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OCC3CC3)C=C2C1C1=CC=C(Cl)C=C1 LNCPCAOWLSIUHY-UHFFFAOYSA-N 0.000 claims 1
DKUWCMYBWAHUTQ-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(cyclopropylmethylamino)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C=1C=C(N2C(CC3=CC=C(NCC4CC4)C=C3C2C=2C=CC(Cl)=CC=2)=O)C=CC=1N(C)CC1=CC=NC=C1 DKUWCMYBWAHUTQ-UHFFFAOYSA-N 0.000 claims 1
GISIOMMIMKOXTN-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(ethylamino)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C12=CC(NCC)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 GISIOMMIMKOXTN-UHFFFAOYSA-N 0.000 claims 1
VVDDORQGXUJPER-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-[2-(dimethylamino)ethyl-propan-2-ylamino]-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C12=CC(N(CCN(C)C)C(C)C)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 VVDDORQGXUJPER-UHFFFAOYSA-N 0.000 claims 1
FCBRTBOGTKJWAZ-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OCCCN(C)C)C=C2C1C1=CC=C(Cl)C=C1 FCBRTBOGTKJWAZ-UHFFFAOYSA-N 0.000 claims 1
PNKLLKMWZQIKPN-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-[ethyl(propan-2-yl)amino]-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C12=CC(N(C(C)C)CC)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 PNKLLKMWZQIKPN-UHFFFAOYSA-N 0.000 claims 1
JACOXKJSMHWXBW-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-[methyl(propan-2-yl)amino]-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C12=CC(N(C)C(C)C)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 JACOXKJSMHWXBW-UHFFFAOYSA-N 0.000 claims 1
ULWYHYVMAQFGPV-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-cyclobutyloxy-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC3CCC3)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 ULWYHYVMAQFGPV-UHFFFAOYSA-N 0.000 claims 1
MHGXKPUYAMKXAI-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-cyclobutyloxy-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OC3CCC3)C=C2C1C1=CC=C(Cl)C=C1 MHGXKPUYAMKXAI-UHFFFAOYSA-N 0.000 claims 1
CYNOADCVDNGVMP-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-cyclohexyloxy-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC3CCCCC3)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 CYNOADCVDNGVMP-UHFFFAOYSA-N 0.000 claims 1
DHGQMFQADXESFR-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-cyclopentyloxy-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC3CCCC3)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 DHGQMFQADXESFR-UHFFFAOYSA-N 0.000 claims 1
ZSLWBMUIYALXCF-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-cyclopentyloxy-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OC3CCCC3)C=C2C1C1=CC=C(Cl)C=C1 ZSLWBMUIYALXCF-UHFFFAOYSA-N 0.000 claims 1
AKPFFHYQTZCFGK-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-methoxy-2-(4-methoxyphenyl)-6-(2-morpholin-4-ylethoxy)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OCCN3CCOCC3)=C(OC)C=C2C1C1=CC=C(Cl)C=C1 AKPFFHYQTZCFGK-UHFFFAOYSA-N 0.000 claims 1
WZUWEYHQEOXAPA-KGUSEGQSSA-N 1-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]piperidine-4-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC(C(N)=O)CC1 WZUWEYHQEOXAPA-KGUSEGQSSA-N 0.000 claims 1
ZDRUXXFMVAAUQM-QHSQBYJISA-N 1-[2-(aminomethyl)-4-chlorophenyl]-7-[(2r)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)CN)N1C1=CC=C(N(C)C)C=C1 ZDRUXXFMVAAUQM-QHSQBYJISA-N 0.000 claims 1
ARAFNDUTCGIPIF-HZRSZRRBSA-N 1-[2-[7-[(2r)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)NC1=CC(Cl)=CC=C1C1C2=CC(O[C@H](C)CC)=C(OC)C=C2CC(=O)N1C1=CC=C(N(C)C)C=C1 ARAFNDUTCGIPIF-HZRSZRRBSA-N 0.000 claims 1
MEMPXHHRCPTSPQ-QHSQBYJISA-N 1-[2-[7-[(2r)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorophenyl]-3-methylurea Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)NC(=O)NC)N1C1=CC=C(N(C)C)C=C1 MEMPXHHRCPTSPQ-QHSQBYJISA-N 0.000 claims 1
WGYKJEFTTXDLPM-YFTDMWITSA-N 1-acetyl-n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-ethylpiperidine-4-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)C1CCN(C(C)=O)CC1 WGYKJEFTTXDLPM-YFTDMWITSA-N 0.000 claims 1
VSFQSMFEUCRBPB-UHFFFAOYSA-N 2-(1-benzofuran-5-yl)-1-(4-chlorophenyl)-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C=C3C=COC3=CC=2)C1C1=CC=C(Cl)C=C1 VSFQSMFEUCRBPB-UHFFFAOYSA-N 0.000 claims 1
RWFZJJVATFIDJU-UHFFFAOYSA-N 2-[2-[1-(4-chlorophenyl)-6,7-diethoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-5-methylphenoxy]acetic acid Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC(C)=CC=2)OCC(O)=O)C1C1=CC=C(Cl)C=C1 RWFZJJVATFIDJU-UHFFFAOYSA-N 0.000 claims 1
FDSGDNWDFWOSKG-UHFFFAOYSA-N 2-[4-(3-amino-5-ethyl-1h-pyrazol-4-yl)phenyl]-1-(4-chlorophenyl)-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound N1N=C(N)C(C=2C=CC(=CC=2)N2C(CC3=CC(OC)=C(OC(C)C)C=C3C2C=2C=CC(Cl)=CC=2)=O)=C1CC FDSGDNWDFWOSKG-UHFFFAOYSA-N 0.000 claims 1
KCHWGOINQZGMEL-MMHRDOBHSA-N 2-[4-[(1-acetylpiperidin-4-yl)methyl-methylamino]phenyl]-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCN(C(C)=O)CC1 KCHWGOINQZGMEL-MMHRDOBHSA-N 0.000 claims 1
NPKXDNQKQFTRBW-JWPKJQAESA-N 2-[4-[(1-butanoylpiperidin-4-yl)methyl-methylamino]phenyl]-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1CN(C(=O)CCC)CCC1CN(C)C1=CC=C(N2C(CC3=CC(OC)=C(O[C@H](C)CC)C=C3C2C=2C=CC(Cl)=CC=2)=O)C=C1 NPKXDNQKQFTRBW-JWPKJQAESA-N 0.000 claims 1
OXJJQMUURYIRHE-MHJPDIQUSA-N 2-[4-[1-(4-acetylpiperazin-1-yl)ethyl]phenyl]-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCN(C(C)=O)CC1 OXJJQMUURYIRHE-MHJPDIQUSA-N 0.000 claims 1
GCXCGDIQFCHUMB-XFBJNOSPSA-N 2-[4-[1-[(1-acetylpiperidin-4-yl)amino]ethyl]phenyl]-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)NC1CCN(C(C)=O)CC1 GCXCGDIQFCHUMB-XFBJNOSPSA-N 0.000 claims 1
FEKNZLNAQTVOJQ-PZYDJRQWSA-N 2-[4-[1-[(3r)-3-aminopyrrolidin-1-yl]ethyl]phenyl]-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CC[C@@H](N)C1 FEKNZLNAQTVOJQ-PZYDJRQWSA-N 0.000 claims 1
HJQCTIJQFOSKJM-KFJXUYOJSA-N 2-[4-[1-[(3s)-3-aminopiperidin-1-yl]ethyl]phenyl]-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC[C@H](N)C1 HJQCTIJQFOSKJM-KFJXUYOJSA-N 0.000 claims 1
FEKNZLNAQTVOJQ-PUICROFKSA-N 2-[4-[1-[(3s)-3-aminopyrrolidin-1-yl]ethyl]phenyl]-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CC[C@H](N)C1 FEKNZLNAQTVOJQ-PUICROFKSA-N 0.000 claims 1
CCBQKDPYECHDEH-KJLUBMIJSA-N 2-[4-[benzyl(methyl)amino]phenyl]-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=CC=C1 CCBQKDPYECHDEH-KJLUBMIJSA-N 0.000 claims 1
VXPGOMCNIIPIBX-YCUTZVODSA-N 2-[4-[butan-2-yl(methyl)amino]phenyl]-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C(C)CC)C=C1 VXPGOMCNIIPIBX-YCUTZVODSA-N 0.000 claims 1
PLYVUCMDEPTIKS-UHFFFAOYSA-N 2-[4-chloro-2-[1-(4-chlorophenyl)-6,7-diethoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenoxy]acetic acid Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC=C(Cl)C=2)OCC(O)=O)C1C1=CC=C(Cl)C=C1 PLYVUCMDEPTIKS-UHFFFAOYSA-N 0.000 claims 1
JEPSLBRGAHBWPO-UHFFFAOYSA-N 2-[5-chloro-2-(2-hydroxyethoxy)phenyl]-1-(4-chlorophenyl)-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC=C(Cl)C=2)OCCO)C1C1=CC=C(Cl)C=C1 JEPSLBRGAHBWPO-UHFFFAOYSA-N 0.000 claims 1
DDSMNBCNXBLKGK-UHFFFAOYSA-N 2-[5-chloro-2-(2-morpholin-4-ylethoxy)phenyl]-1-(4-chlorophenyl)-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC=C(Cl)C=2)OCCN2CCOCC2)C1C1=CC=C(Cl)C=C1 DDSMNBCNXBLKGK-UHFFFAOYSA-N 0.000 claims 1
MLCHJUUBMWHAIQ-UHFFFAOYSA-N 2-[5-chloro-2-(3-hydroxypropoxy)phenyl]-1-(4-chlorophenyl)-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC=C(Cl)C=2)OCCCO)C1C1=CC=C(Cl)C=C1 MLCHJUUBMWHAIQ-UHFFFAOYSA-N 0.000 claims 1
NFHXBIXVQYVNLG-UHFFFAOYSA-N 2-[5-chloro-2-(3-morpholin-4-ylpropoxy)phenyl]-1-(4-chlorophenyl)-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC=C(Cl)C=2)OCCCN2CCOCC2)C1C1=CC=C(Cl)C=C1 NFHXBIXVQYVNLG-UHFFFAOYSA-N 0.000 claims 1
VJUYFAVJFGAQJI-UHFFFAOYSA-N 2-[5-chloro-2-[2-(dimethylamino)ethoxy]phenyl]-1-(4-chlorophenyl)-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC=C(Cl)C=2)OCCN(C)C)C1C1=CC=C(Cl)C=C1 VJUYFAVJFGAQJI-UHFFFAOYSA-N 0.000 claims 1
XJIUQTDGTRZXPG-UHFFFAOYSA-N 2-[5-chloro-2-[3-(dimethylamino)propoxy]phenyl]-1-(4-chlorophenyl)-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC=C(Cl)C=2)OCCCN(C)C)C1C1=CC=C(Cl)C=C1 XJIUQTDGTRZXPG-UHFFFAOYSA-N 0.000 claims 1
JRHHGSISIYTFKK-QHSQBYJISA-N 2-[7-[(2r)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chloro-n-methylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)C(=O)NC)N1C1=CC=C(N(C)C)C=C1 JRHHGSISIYTFKK-QHSQBYJISA-N 0.000 claims 1
YXFUXFRGJVZDGR-WPUOIDIFSA-N 2-[7-[(2r)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorobenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)C(N)=O)N1C1=CC=C(N(C)C)C=C1 YXFUXFRGJVZDGR-WPUOIDIFSA-N 0.000 claims 1
YCWHCXOQTNXEOQ-HZRSZRRBSA-N 2-[[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(4-methoxyphenyl)-3-oxo-1,4-dihydroisoquinolin-6-yl]oxy]-n,n-dimethylacetamide Chemical compound O=C1CC=2C=C(OCC(=O)N(C)C)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 YCWHCXOQTNXEOQ-HZRSZRRBSA-N 0.000 claims 1
VXURYYOGRCRVAD-QHSQBYJISA-N 2-[[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(4-methoxyphenyl)-3-oxo-1,4-dihydroisoquinolin-6-yl]oxy]-n-methylacetamide Chemical compound O=C1CC=2C=C(OCC(=O)NC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 VXURYYOGRCRVAD-QHSQBYJISA-N 0.000 claims 1
WCBRMAYCVKGXQA-UHFFFAOYSA-N 4-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-6,7-dimethoxy-1,4-dihydroquinazolin-2-one Chemical compound C1=2C=C(OC)C(OC)=CC=2NC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 WCBRMAYCVKGXQA-UHFFFAOYSA-N 0.000 claims 1
FJENVYOWUKWINX-UHFFFAOYSA-N 4-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-6,7-dimethoxy-1-methyl-4h-quinazolin-2-one Chemical compound O=C1N(C)C=2C=C(OC)C(OC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 FJENVYOWUKWINX-UHFFFAOYSA-N 0.000 claims 1
UWRTWDHHFWNXHR-UHFFFAOYSA-N 4-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-6,7-dimethoxy-1-propan-2-yl-4h-quinazolin-2-one Chemical compound O=C1N(C(C)C)C=2C=C(OC)C(OC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 UWRTWDHHFWNXHR-UHFFFAOYSA-N 0.000 claims 1
UXMFFRFGEASXKL-UHFFFAOYSA-N 4-(4-chlorophenyl)-6,7-dimethoxy-3-(4-methoxyphenyl)-1,4-dihydroquinazolin-2-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)NC2=CC(OC)=C(OC)C=C2C1C1=CC=C(Cl)C=C1 UXMFFRFGEASXKL-UHFFFAOYSA-N 0.000 claims 1
KMDWMNNOGQIKKJ-SONOPUAISA-N 4-[(1r)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-n-ethyl-n-methylbenzamide Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C1=CC=C(C(=O)N(C)CC)C=C1 KMDWMNNOGQIKKJ-SONOPUAISA-N 0.000 claims 1
XSLLHXSBGFXGQO-GEFUHLBYSA-N 4-[(1s)-1-[4-[(1s)-1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]morpholin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@H](C)N2C(COCC2)=O)=CC=C(Cl)C=C1 XSLLHXSBGFXGQO-GEFUHLBYSA-N 0.000 claims 1
KMDWMNNOGQIKKJ-XBBWARJSSA-N 4-[(1s)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-n-ethyl-n-methylbenzamide Chemical compound N1([C@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C1=CC=C(C(=O)N(C)CC)C=C1 KMDWMNNOGQIKKJ-XBBWARJSSA-N 0.000 claims 1
WDKJMFIAJNKDOF-UHFFFAOYSA-N 4-[1-(4-chlorophenyl)-6,7-diethoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]benzonitrile Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C=CC(=CC=2)C#N)C1C1=CC=C(Cl)C=C1 WDKJMFIAJNKDOF-UHFFFAOYSA-N 0.000 claims 1
JGOSSRBMKCJJIY-DHFMJDSQSA-N 4-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]morpholin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCOCC1=O JGOSSRBMKCJJIY-DHFMJDSQSA-N 0.000 claims 1
QOLTZMPOMACYPK-UEWHNOOISA-N 4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-n,n-diethylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(=O)N(CC)CC)C=C1 QOLTZMPOMACYPK-UEWHNOOISA-N 0.000 claims 1
TVNIKLNLRXIQTJ-KUFXBUICSA-N 4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-n,n-dimethylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(=O)N(C)C)C=C1 TVNIKLNLRXIQTJ-KUFXBUICSA-N 0.000 claims 1
KMDWMNNOGQIKKJ-COBFLCELSA-N 4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-n-ethyl-n-methylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(=O)N(C)CC)C=C1 KMDWMNNOGQIKKJ-COBFLCELSA-N 0.000 claims 1
RBLIIYLWBPXMKY-LFDVRYLKSA-N 4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-n-methyl-n-pyridin-4-ylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(=O)N(C)C1=CC=NC=C1 RBLIIYLWBPXMKY-LFDVRYLKSA-N 0.000 claims 1
IUQAKEHMVHKSQK-MOJDWNGGSA-N 4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-n-methylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(=O)NC)C=C1 IUQAKEHMVHKSQK-MOJDWNGGSA-N 0.000 claims 1
SRTLVNYOFHBWLX-DXHYANOHSA-N 4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-n-pyridin-3-ylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(=O)NC1=CC=CN=C1 SRTLVNYOFHBWLX-DXHYANOHSA-N 0.000 claims 1
RNWVPOVKXVXIJL-DXHYANOHSA-N 4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-n-pyridin-4-ylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(=O)NC1=CC=NC=C1 RNWVPOVKXVXIJL-DXHYANOHSA-N 0.000 claims 1
QHMCRBZHTBCHBB-DIERRCTGSA-N 4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]benzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(N)=O)C=C1 QHMCRBZHTBCHBB-DIERRCTGSA-N 0.000 claims 1
UGPJKFXFWRTNJI-YAYCPNDQSA-N 4-[[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-n-methylanilino]methyl]-n,n-dimethylpiperidine-1-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCN(C(=O)N(C)C)CC1 UGPJKFXFWRTNJI-YAYCPNDQSA-N 0.000 claims 1
DRNGLYHKYPNTEA-UHFFFAOYSA-N 4-azaniumylcyclohexane-1-carboxylate Chemical compound NC1CCC(C(O)=O)CC1 DRNGLYHKYPNTEA-UHFFFAOYSA-N 0.000 claims 1
SPROQMZYTFZBOG-UHFFFAOYSA-N 6-(2-aminoethoxy)-1-(4-chlorophenyl)-7-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OCCN)=C(OC)C=C2C1C1=CC=C(Cl)C=C1 SPROQMZYTFZBOG-UHFFFAOYSA-N 0.000 claims 1
JDGMSDUWQJREIM-OJQMSQGESA-N 6-[(2r)-butan-2-yl]oxy-4-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-1-ethyl-7-methoxy-4h-quinazolin-2-one Chemical compound O=C1N(CC)C=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 JDGMSDUWQJREIM-OJQMSQGESA-N 0.000 claims 1
PLFZIENRXZPGRC-SIHBAMTISA-N 6-[(2r)-butan-2-yl]oxy-4-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-7-methoxy-1,4-dihydroquinazolin-2-one Chemical compound O=C1NC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 PLFZIENRXZPGRC-SIHBAMTISA-N 0.000 claims 1
ICTSOMVZHLHDMW-XZATXCMXSA-N 6-[(2r)-butan-2-yl]oxy-4-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-7-methoxy-1-methyl-4h-quinazolin-2-one Chemical compound O=C1N(C)C=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 ICTSOMVZHLHDMW-XZATXCMXSA-N 0.000 claims 1
VKBFVDLFDUMDJH-ZRTDVJLTSA-N 6-[(2r)-butan-2-yl]oxy-4-(4-chlorophenyl)-7-methoxy-3-(4-methoxyphenyl)-1,4-dihydroquinazolin-2-one Chemical compound O=C1NC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 VKBFVDLFDUMDJH-ZRTDVJLTSA-N 0.000 claims 1
SPERJNVVAORMFD-UHFFFAOYSA-N 7-(3-aminopropoxy)-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OCCCN)C=C2C1C1=CC=C(Cl)C=C1 SPERJNVVAORMFD-UHFFFAOYSA-N 0.000 claims 1
VJILSXLNURLYKQ-UHFFFAOYSA-N 7-(4-aminobutan-2-yloxy)-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OC(C)CCN)C=C2C1C1=CC=C(Cl)C=C1 VJILSXLNURLYKQ-UHFFFAOYSA-N 0.000 claims 1
HDRUEURGRSLHGV-UHFFFAOYSA-N 7-(benzylamino)-1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C=1C=C(N2C(CC3=CC=C(NCC=4C=CC=CC=4)C=C3C2C=2C=CC(Cl)=CC=2)=O)C=CC=1N(C)CC1=CC=NC=C1 HDRUEURGRSLHGV-UHFFFAOYSA-N 0.000 claims 1
RWPVJYLYROQPGA-UHFFFAOYSA-N 7-(butan-2-ylamino)-1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C12=CC(NC(C)CC)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 RWPVJYLYROQPGA-UHFFFAOYSA-N 0.000 claims 1
NHJBFVAZLNVPEB-ATXVKEFZSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[[4-(ethylamino)cyclohexyl]methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1CC(NCC)CCC1CN(C)C1=CC=C(N2C(CC3=CC(OC)=C(O[C@H](C)CC)C=C3C2C=2C=CC(Cl)=CC=2)=O)C=C1 NHJBFVAZLNVPEB-ATXVKEFZSA-N 0.000 claims 1
FNFFGCOHCCHIDU-AZXPTMDGSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[[4-[ethyl(methyl)amino]cyclohexyl]methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCC(N(C)CC)CC1 FNFFGCOHCCHIDU-AZXPTMDGSA-N 0.000 claims 1
XANMKHLJUIDKIA-COBFLCELSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chloro-2-methylphenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)C)N1C1=CC=C(N(C)C)C=C1 XANMKHLJUIDKIA-COBFLCELSA-N 0.000 claims 1
WIPMDHIKQIIBRZ-WPUOIDIFSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chloro-3-fluorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=C(F)C(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 WIPMDHIKQIIBRZ-WPUOIDIFSA-N 0.000 claims 1
ZDFNGXONWSEQIW-COBFLCELSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chloro-3-methylphenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=C(C)C(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 ZDFNGXONWSEQIW-COBFLCELSA-N 0.000 claims 1
MZZAHEIEFZBLAM-WPUOIDIFSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chloro-3-nitrophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=C(C(Cl)=CC=2)[N+]([O-])=O)N1C1=CC=C(N(C)C)C=C1 MZZAHEIEFZBLAM-WPUOIDIFSA-N 0.000 claims 1
UJXGRVKFFJNJHW-WPUOIDIFSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(2,4-dimethoxyphenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1OC UJXGRVKFFJNJHW-WPUOIDIFSA-N 0.000 claims 1
YNACVAVWLRGYTJ-OJQMSQGESA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(2,4-dimethylphenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C)C=C1C YNACVAVWLRGYTJ-OJQMSQGESA-N 0.000 claims 1
HIYNOZILCATDQE-GJNAARLKSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(Cl)C(Cl)=C1 HIYNOZILCATDQE-GJNAARLKSA-N 0.000 claims 1
LZLWYZVRKPFOMW-WPUOIDIFSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(3,4-dimethoxyphenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C(OC)=C1 LZLWYZVRKPFOMW-WPUOIDIFSA-N 0.000 claims 1
SXOZWLOGBOOJGT-OJQMSQGESA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(3,4-dimethylphenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C)C(C)=C1 SXOZWLOGBOOJGT-OJQMSQGESA-N 0.000 claims 1
LASKDMXYDZITII-UEWHNOOISA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(4-methoxyphenyl)-6-(2-methylpropoxy)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OCC(C)C)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 LASKDMXYDZITII-UEWHNOOISA-N 0.000 claims 1
NQDGYXBFKYQRNB-LWMFVPLKSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(4-methoxyphenyl)-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]-1,4-dihydroisoquinolin-3-one Chemical compound CC[C@@H](C)OC1=CC=2C(C=3C=CC(Cl)=CC=3)N(C=3C=CC(OC)=CC=3)C(=O)CC=2C=C1OCC(=O)N1CCN(C)CC1 NQDGYXBFKYQRNB-LWMFVPLKSA-N 0.000 claims 1
IZNBOAXCTAKMTE-COBFLCELSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(4-methoxyphenyl)-6-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC(C)C)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 IZNBOAXCTAKMTE-COBFLCELSA-N 0.000 claims 1
VPRKVRZMYBXTBU-COBFLCELSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(4-methoxyphenyl)-6-propoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(O[C@H](C)CC)C(OCCC)=CC=2CC(=O)N(C=2C=CC(OC)=CC=2)C1C1=CC=C(Cl)C=C1 VPRKVRZMYBXTBU-COBFLCELSA-N 0.000 claims 1
ALFZUDGOPZPEEV-JKTWZELDSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(1-hydroxyethyl)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)O)C=C1 ALFZUDGOPZPEEV-JKTWZELDSA-N 0.000 claims 1
BZXDBHNFAVZURR-BPNQMYTISA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(3,5-dimethyl-1h-pyrazol-4-yl)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C=1C(C)=NNC=1C BZXDBHNFAVZURR-BPNQMYTISA-N 0.000 claims 1
MDVVWBPMXFTBHY-UEWHNOOISA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(diethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(CC)CC)C=C1 MDVVWBPMXFTBHY-UEWHNOOISA-N 0.000 claims 1
NQHVYBHGANOBDK-QHSQBYJISA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(dimethylamino)-2-methoxyphenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1OC NQHVYBHGANOBDK-QHSQBYJISA-N 0.000 claims 1
YRAPUEIRQLUTOO-COBFLCELSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(dimethylamino)-2-methylphenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1C YRAPUEIRQLUTOO-COBFLCELSA-N 0.000 claims 1
WFSJVHLKSNYJNJ-KUFXBUICSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 WFSJVHLKSNYJNJ-KUFXBUICSA-N 0.000 claims 1
IBEZDRDXZURKDS-GFTAOQHMSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(dipropylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(N(CCC)CCC)=CC=C1N1C(=O)CC2=CC(OC)=C(O[C@H](C)CC)C=C2C1C1=CC=C(Cl)C=C1 IBEZDRDXZURKDS-GFTAOQHMSA-N 0.000 claims 1
YONHVRPOCPIMLH-KUFXBUICSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(ethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(NCC)=CC=C1N1C(=O)CC2=CC(OC)=C(O[C@H](C)CC)C=C2C1C1=CC=C(Cl)C=C1 YONHVRPOCPIMLH-KUFXBUICSA-N 0.000 claims 1
JJLIBSXLCMDFQN-MOJDWNGGSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(hydroxymethyl)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(CO)C=C1 JJLIBSXLCMDFQN-MOJDWNGGSA-N 0.000 claims 1
UZJSRPMFHLXPHV-VZESWDRUSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(2,3-difluorophenyl)methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=CC(F)=C1F UZJSRPMFHLXPHV-VZESWDRUSA-N 0.000 claims 1
VMCBHKDWUHBLLH-PVFJFFHYSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(2-fluorophenyl)methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=CC=C1F VMCBHKDWUHBLLH-PVFJFFHYSA-N 0.000 claims 1
CMPUGZMYMCNDNR-VZESWDRUSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(3,4-difluorophenyl)methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=C(F)C(F)=C1 CMPUGZMYMCNDNR-VZESWDRUSA-N 0.000 claims 1
IIUUWNOYXDCTMQ-PVFJFFHYSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(3-fluorophenyl)methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=CC(F)=C1 IIUUWNOYXDCTMQ-PVFJFFHYSA-N 0.000 claims 1
ZPDDLUSCRIMLHQ-GGPMTTHASA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(3-fluoropyridin-4-yl)methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=NC=C1F ZPDDLUSCRIMLHQ-GGPMTTHASA-N 0.000 claims 1
UPIGHRRSNOLMSP-PVFJFFHYSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(4-fluorophenyl)methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=C(F)C=C1 UPIGHRRSNOLMSP-PVFJFFHYSA-N 0.000 claims 1
VJKLOQORULSKFF-KGUSEGQSSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-(4-hydroxypiperidin-1-yl)ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC(O)CC1 VJKLOQORULSKFF-KGUSEGQSSA-N 0.000 claims 1
NZESLGIMRIFPHV-BYIWRISSSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-(dimethylamino)ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)N(C)C)C=C1 NZESLGIMRIFPHV-BYIWRISSSA-N 0.000 claims 1
PRNZCVIDSHKDNA-AZMKAGDRSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[(3r)-3-(dimethylamino)pyrrolidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CC[C@@H](N(C)C)C1 PRNZCVIDSHKDNA-AZMKAGDRSA-N 0.000 claims 1
GYGWNGPTHLLSMO-JRTRQYOMSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[(3r)-3-hydroxypiperidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC[C@@H](O)C1 GYGWNGPTHLLSMO-JRTRQYOMSA-N 0.000 claims 1
LCOSUZXFINJPCD-FVQHBTCESA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[(3r)-3-hydroxypyrrolidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CC[C@@H](O)C1 LCOSUZXFINJPCD-FVQHBTCESA-N 0.000 claims 1
DIXHRXPCUUVAHD-HHCNDGNYSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[(3s)-3-(dimethylamino)piperidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC[C@H](N(C)C)C1 DIXHRXPCUUVAHD-HHCNDGNYSA-N 0.000 claims 1
PRNZCVIDSHKDNA-JAHCQJHZSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[(3s)-3-(dimethylamino)pyrrolidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CC[C@H](N(C)C)C1 PRNZCVIDSHKDNA-JAHCQJHZSA-N 0.000 claims 1
GYGWNGPTHLLSMO-YGAMUSMISA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[(3s)-3-hydroxypiperidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC[C@H](O)C1 GYGWNGPTHLLSMO-YGAMUSMISA-N 0.000 claims 1
LCOSUZXFINJPCD-RQVNELMKSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[(3s)-3-hydroxypyrrolidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CC[C@H](O)C1 LCOSUZXFINJPCD-RQVNELMKSA-N 0.000 claims 1
HRXDZOTWDGLFEY-XOBGVXBPSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[2-(dimethylamino)ethylamino]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)NCCN(C)C)C=C1 HRXDZOTWDGLFEY-XOBGVXBPSA-N 0.000 claims 1
UTFACQMLQPKAMT-BPQYTBSDSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[4-(diethylamino)piperidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC(N(CC)CC)CC1 UTFACQMLQPKAMT-BPQYTBSDSA-N 0.000 claims 1
GYPIVOQVWAXHTL-BKCPDIIESA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[4-(dimethylamino)piperidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC(N(C)C)CC1 GYPIVOQVWAXHTL-BKCPDIIESA-N 0.000 claims 1
MWSVWRXYPZBKKI-BKCPDIIESA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[ethyl(piperidin-4-yl)amino]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C1CCNCC1 MWSVWRXYPZBKKI-BKCPDIIESA-N 0.000 claims 1
SUPMGGSRFVOUPP-JWPKJQAESA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[[1-(cyclobutanecarbonyl)piperidin-4-yl]methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC(CC1)CCN1C(=O)C1CCC1 SUPMGGSRFVOUPP-JWPKJQAESA-N 0.000 claims 1
PDKRAXLLYFKWKW-LHTANEHXSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[[1-(cyclopropanecarbonyl)piperidin-4-yl]methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC(CC1)CCN1C(=O)C1CC1 PDKRAXLLYFKWKW-LHTANEHXSA-N 0.000 claims 1
HNTSTHIXELQIPD-DXHYANOHSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclobutyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C1CCC1 HNTSTHIXELQIPD-DXHYANOHSA-N 0.000 claims 1
NEJMSBJUNRLLHK-LWMFVPLKSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclohexyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C1CCCCC1 NEJMSBJUNRLLHK-LWMFVPLKSA-N 0.000 claims 1
RZRBVIFRDBTMPA-KJLUBMIJSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclohexylmethyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCCCC1 RZRBVIFRDBTMPA-KJLUBMIJSA-N 0.000 claims 1
LIHRLMVZGOPNGV-LFDVRYLKSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclopentyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C1CCCC1 LIHRLMVZGOPNGV-LFDVRYLKSA-N 0.000 claims 1
VFFNEZDWIBZNQT-LWMFVPLKSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclopentylmethyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCCC1 VFFNEZDWIBZNQT-LWMFVPLKSA-N 0.000 claims 1
NQEKLQPGKRJSLR-DXHYANOHSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclopropylmethyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CC1 NQEKLQPGKRJSLR-DXHYANOHSA-N 0.000 claims 1
KSAOEVWTPSXOAI-LHTANEHXSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclopropylmethyl(pyridin-4-ylmethyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(CC=1C=CN=CC=1)CC1CC1 KSAOEVWTPSXOAI-LHTANEHXSA-N 0.000 claims 1
OKUUYLUYHPMBTE-COBFLCELSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[ethyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)CC)C=C1 OKUUYLUYHPMBTE-COBFLCELSA-N 0.000 claims 1
XYROPMRDJQRZQO-LFDVRYLKSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[furan-3-ylmethyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC=1C=COC=1 XYROPMRDJQRZQO-LFDVRYLKSA-N 0.000 claims 1
YOTZCWQSUJCUQM-COBFLCELSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-(3-hydroxypropoxy)-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OCCCO)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 YOTZCWQSUJCUQM-COBFLCELSA-N 0.000 claims 1
WIRWVJIKHXPPPF-UBIBJYAGSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-[3-(dimethylamino)propoxy]-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OCCCN(C)C)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 WIRWVJIKHXPPPF-UBIBJYAGSA-N 0.000 claims 1
LFLACZRNZALIIF-KUFXBUICSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-ethoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(O[C@H](C)CC)C(OCC)=CC=2CC(=O)N(C=2C=CC(OC)=CC=2)C1C1=CC=C(Cl)C=C1 LFLACZRNZALIIF-KUFXBUICSA-N 0.000 claims 1
AGDZKJPJHMEPJW-WPUOIDIFSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(1-methylindazol-5-yl)-1,4-dihydroisoquinolin-3-one Chemical compound C=1C=C2N(C)N=CC2=CC=1N1C(=O)CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C1C1=CC=C(Cl)C=C1 AGDZKJPJHMEPJW-WPUOIDIFSA-N 0.000 claims 1
SNYJOABYQQMNMR-DXHYANOHSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(2-methoxy-4-morpholin-4-ylphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C(=C1)OC)=CC=C1N1CCOCC1 SNYJOABYQQMNMR-DXHYANOHSA-N 0.000 claims 1
ALKKFALWFQJEEH-KUFXBUICSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(2-methoxy-5-methylphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC(C)=CC=C1OC ALKKFALWFQJEEH-KUFXBUICSA-N 0.000 claims 1
NFLOANPRJQMBJE-KUFXBUICSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxy-2-methylphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1C NFLOANPRJQMBJE-KUFXBUICSA-N 0.000 claims 1
GQUCZUQLQVPONT-MOJDWNGGSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 GQUCZUQLQVPONT-MOJDWNGGSA-N 0.000 claims 1
PZAJLQJGZRXWJJ-XZATXCMXSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-methylphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C)C=C1 PZAJLQJGZRXWJJ-XZATXCMXSA-N 0.000 claims 1
SMESOWQZCFBECR-COBFLCELSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-pyrazol-1-ylphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N1C=CC=N1 SMESOWQZCFBECR-COBFLCELSA-N 0.000 claims 1
LUWAWFOOPZTPHR-UEWHNOOISA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-pyrrolidin-1-ylphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N1CCCC1 LUWAWFOOPZTPHR-UEWHNOOISA-N 0.000 claims 1
RSKLVMJITCOSKY-XOBGVXBPSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(1-morpholin-4-ylethyl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCOCC1 RSKLVMJITCOSKY-XOBGVXBPSA-N 0.000 claims 1
LBHRNHIJVFKNRX-XOBGVXBPSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(1-pyrrolidin-1-ylethyl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCCC1 LBHRNHIJVFKNRX-XOBGVXBPSA-N 0.000 claims 1
SRGSBORUYIIAQG-XOBGVXBPSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(1-thiomorpholin-4-ylethyl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCSCC1 SRGSBORUYIIAQG-XOBGVXBPSA-N 0.000 claims 1
SXFXYYOGQWUAAF-QHSQBYJISA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(1h-pyrazol-4-yl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C=1C=NNC=1 SXFXYYOGQWUAAF-QHSQBYJISA-N 0.000 claims 1
SSACIXCQKGESKK-QHSQBYJISA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(2-oxoazetidin-1-yl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N1CCC1=O SSACIXCQKGESKK-QHSQBYJISA-N 0.000 claims 1
DERUQPZTBLGCOC-HZRSZRRBSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N1CCCC1=O DERUQPZTBLGCOC-HZRSZRRBSA-N 0.000 claims 1
LBOWNFDUJCWXEG-UBIBJYAGSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(piperidine-1-carbonyl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(=O)N1CCCCC1 LBOWNFDUJCWXEG-UBIBJYAGSA-N 0.000 claims 1
WZOZQGYBVVLCBN-LFDVRYLKSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(pyridin-4-ylmethylamino)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1NCC1=CC=NC=C1 WZOZQGYBVVLCBN-LFDVRYLKSA-N 0.000 claims 1
HFNKGSIJKTZXHH-UEWHNOOISA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(pyrrolidine-1-carbonyl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(=O)N1CCCC1 HFNKGSIJKTZXHH-UEWHNOOISA-N 0.000 claims 1
KHAYFXPJPHDPRJ-KGUSEGQSSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[1-(piperidin-4-ylamino)ethyl]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)NC1CCNCC1 KHAYFXPJPHDPRJ-KGUSEGQSSA-N 0.000 claims 1
JHUAOSPKENTLLI-BPQYTBSDSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[1-[4-[methyl(propan-2-yl)amino]piperidin-1-yl]ethyl]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC(N(C)C(C)C)CC1 JHUAOSPKENTLLI-BPQYTBSDSA-N 0.000 claims 1
KSAONEXUAWOLBR-MFESXJPLSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[1-[[(3r)-piperidin-3-yl]amino]ethyl]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N[C@@H]1CCCNC1 KSAONEXUAWOLBR-MFESXJPLSA-N 0.000 claims 1
KSAONEXUAWOLBR-KFJXUYOJSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[1-[[(3s)-piperidin-3-yl]amino]ethyl]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N[C@H]1CCCNC1 KSAONEXUAWOLBR-KFJXUYOJSA-N 0.000 claims 1
OQQLKHVTFRESEW-MHJPDIQUSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[1-[methyl(piperidin-4-yl)amino]ethyl]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C)C1CCNCC1 OQQLKHVTFRESEW-MHJPDIQUSA-N 0.000 claims 1
XLEPUYFEPCHSRB-FFTVHEIDSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[2-morpholin-4-ylethyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(CC=1C=CN=CC=1)CCN1CCOCC1 XLEPUYFEPCHSRB-FFTVHEIDSA-N 0.000 claims 1
GMZPGKTYXMTUCG-UBIBJYAGSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(2-methylpropyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)CC(C)C)C=C1 GMZPGKTYXMTUCG-UBIBJYAGSA-N 0.000 claims 1
MFYDVQJFKNFAHN-PXWGLLCJSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(2-morpholin-4-ylethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CCN1CCOCC1 MFYDVQJFKNFAHN-PXWGLLCJSA-N 0.000 claims 1
RMGSYAJRAGOIFI-PPFXIRLKSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(piperidin-3-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCCNC1 RMGSYAJRAGOIFI-PPFXIRLKSA-N 0.000 claims 1
NCDHHXTYFKEITD-LWMFVPLKSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(piperidin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCNCC1 NCDHHXTYFKEITD-LWMFVPLKSA-N 0.000 claims 1
AQKOWJRANBMAEK-UEWHNOOISA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(propan-2-yl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C(C)C)C=C1 AQKOWJRANBMAEK-UEWHNOOISA-N 0.000 claims 1
KGABRCQQSZHECR-LWMFVPLKSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(pyridin-3-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=CN=C1 KGABRCQQSZHECR-LWMFVPLKSA-N 0.000 claims 1
RNOXGLRIZIHGIA-LWMFVPLKSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=NC=C1 RNOXGLRIZIHGIA-LWMFVPLKSA-N 0.000 claims 1
BEYNTDAQYVKKKL-LFDVRYLKSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(pyrimidin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=NC=N1 BEYNTDAQYVKKKL-LFDVRYLKSA-N 0.000 claims 1
SXCHORGFKAEYIR-LFDVRYLKSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(thiophen-3-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC=1C=CSC=1 SXCHORGFKAEYIR-LFDVRYLKSA-N 0.000 claims 1
FMWULHHMNFVCEP-MPFIGGLTSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl-[(1-methylpiperidin-3-yl)methyl]amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCCN(C)C1 FMWULHHMNFVCEP-MPFIGGLTSA-N 0.000 claims 1
JTAZSLOEHWHZFD-KJLUBMIJSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl-[(1-methylpiperidin-4-yl)methyl]amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCN(C)CC1 JTAZSLOEHWHZFD-KJLUBMIJSA-N 0.000 claims 1
NQKUMYQVZUUXRL-KJLUBMIJSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl-[(1-methylsulfonylpiperidin-4-yl)methyl]amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCN(S(C)(=O)=O)CC1 NQKUMYQVZUUXRL-KJLUBMIJSA-N 0.000 claims 1
CBBZINCEKPYEHC-LHTANEHXSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl-[(1-propanoylpiperidin-4-yl)methyl]amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCN(C(=O)CC)CC1 CBBZINCEKPYEHC-LHTANEHXSA-N 0.000 claims 1
UUCKXDZWDCRZQW-LFDVRYLKSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl-[(3-methylimidazol-4-yl)methyl]amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CN=CN1C UUCKXDZWDCRZQW-LFDVRYLKSA-N 0.000 claims 1
DXTSZJGQJUWBJZ-NNHKGWTCSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl-[[1-(2-methylpropanoyl)piperidin-4-yl]methyl]amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCN(C(=O)C(C)C)CC1 DXTSZJGQJUWBJZ-NNHKGWTCSA-N 0.000 claims 1
JAVOSGCWJFBDGY-PVFJFFHYSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl-[[3-(trifluoromethyl)phenyl]methyl]amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=CC(C(F)(F)F)=C1 JAVOSGCWJFBDGY-PVFJFFHYSA-N 0.000 claims 1
UQYPZRILKXVPTB-PVFJFFHYSA-N 7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl-[[4-(trifluoromethyl)phenyl]methyl]amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=C(C(F)(F)F)C=C1 UQYPZRILKXVPTB-PVFJFFHYSA-N 0.000 claims 1
UCGICFRBXLRKKA-HZRSZRRBSA-N 7-[(2r)-butan-2-yl]oxy-1-[4-chloro-2-(dimethylamino)phenyl]-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)N(C)C)N1C1=CC=C(N(C)C)C=C1 UCGICFRBXLRKKA-HZRSZRRBSA-N 0.000 claims 1
JIQILQRONOEITE-QHSQBYJISA-N 7-[(2r)-butan-2-yl]oxy-1-[4-chloro-2-(hydroxymethyl)phenyl]-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)CO)N1C1=CC=C(N(C)C)C=C1 JIQILQRONOEITE-QHSQBYJISA-N 0.000 claims 1
UQEUUKDCDNLWJE-DXHYANOHSA-N 7-[(2r)-butan-2-yl]oxy-1-[4-chloro-2-[ethyl(methyl)amino]phenyl]-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)N(C)CC)N1C1=CC=C(N(C)C)C=C1 UQEUUKDCDNLWJE-DXHYANOHSA-N 0.000 claims 1
KCIOSMXVAZHKFV-MOJDWNGGSA-N 7-[(2r)-butan-2-yl]oxy-2-(2-chloro-4-methylphenyl)-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C)C=C1Cl KCIOSMXVAZHKFV-MOJDWNGGSA-N 0.000 claims 1
WFSJVHLKSNYJNJ-BVFFRPSBSA-N 7-[(2s)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 WFSJVHLKSNYJNJ-BVFFRPSBSA-N 0.000 claims 1
GQUCZUQLQVPONT-OIGLVOGNSA-N 7-[(2s)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 GQUCZUQLQVPONT-OIGLVOGNSA-N 0.000 claims 1
GQUCZUQLQVPONT-UHFFFAOYSA-N 7-butan-2-yloxy-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(OC(C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 GQUCZUQLQVPONT-UHFFFAOYSA-N 0.000 claims 1
QQQGPZUYAUJNOA-BXKNEMSHSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C(=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N(C)C)OC)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C(=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N(C)C)OC)=CC=C(Cl)C=C1 QQQGPZUYAUJNOA-BXKNEMSHSA-N 0.000 claims 1
IYEBYKVJBDNQGL-JUPNEIPRSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C(=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)F)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C(=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)F)=CC=C(Cl)C=C1 IYEBYKVJBDNQGL-JUPNEIPRSA-N 0.000 claims 1
UUIBRRARLBWRNX-JUPNEIPRSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C(=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)NCC2)OC)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C(=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)NCC2)OC)=CC=C(Cl)C=C1 UUIBRRARLBWRNX-JUPNEIPRSA-N 0.000 claims 1
CRWIWSMAGSTGOV-YFMCWZQFSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C(=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)NC(=O)OC(C)(C)C)OC)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C(=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)NC(=O)OC(C)(C)C)OC)=CC=C(Cl)C=C1 CRWIWSMAGSTGOV-YFMCWZQFSA-N 0.000 claims 1
MUNNWFBLWBFTRL-BXKNEMSHSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C(=NC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)F)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C(=NC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)F)=CC=C(Cl)C=C1 MUNNWFBLWBFTRL-BXKNEMSHSA-N 0.000 claims 1
PNFZCZJCPADWSK-GDLCEAIKSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=C(C)C(N(C)C[C@@H]3CC[C@H](CC3)N(C)C)=CC=2)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=C(C)C(N(C)C[C@@H]3CC[C@H](CC3)N(C)C)=CC=2)=CC=C(Cl)C=C1 PNFZCZJCPADWSK-GDLCEAIKSA-N 0.000 claims 1
VPNHKDQQSKFPFG-TWCVDLNQSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=C(F)C(N(C)C[C@@H]3CC[C@H](CC3)N(C)C)=CC=2)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=C(F)C(N(C)C[C@@H]3CC[C@H](CC3)N(C)C)=CC=2)=CC=C(Cl)C=C1 VPNHKDQQSKFPFG-TWCVDLNQSA-N 0.000 claims 1
YZEZAHFLOJNPDQ-JUPNEIPRSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=C(F)C(N(C)C[C@@H]3CC[C@H](CC3)N3CC(=O)N(C)CC3)=CC=2)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=C(F)C(N(C)C[C@@H]3CC[C@H](CC3)N3CC(=O)N(C)CC3)=CC=2)=CC=C(Cl)C=C1 YZEZAHFLOJNPDQ-JUPNEIPRSA-N 0.000 claims 1
NCFWLCHCOYXXLD-BVLDHWHNSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C(=O)[C@@H]2CC[C@H](CC2)N(C)C)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C(=O)[C@@H]2CC[C@H](CC2)N(C)C)=CC=C(Cl)C=C1 NCFWLCHCOYXXLD-BVLDHWHNSA-N 0.000 claims 1
OROAYEHPIYOLJG-HPXQRVPSSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@@H](CC2)N2C(CNCC2)=O)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@@H](CC2)N2C(CNCC2)=O)=CC=C(Cl)C=C1 OROAYEHPIYOLJG-HPXQRVPSSA-N 0.000 claims 1
XCGZLIYHEWEXLW-KCPSNSNRSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)C(=O)NCC(C)(C)O)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)C(=O)NCC(C)(C)O)=CC=C(Cl)C=C1 XCGZLIYHEWEXLW-KCPSNSNRSA-N 0.000 claims 1
ZAGWLCDUNYVHGV-YMHOBPSFSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)C(=O)NCCO)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)C(=O)NCCO)=CC=C(Cl)C=C1 ZAGWLCDUNYVHGV-YMHOBPSFSA-N 0.000 claims 1
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HYKCPCLAAGNDIK-DEHZDLLQSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(C)CC(C)C)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(C)CC(C)C)CC1 HYKCPCLAAGNDIK-DEHZDLLQSA-N 0.000 claims 1
WJLGIZVNZCLDIH-AKVZGJDWSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(CC)C(=O)N(C)C)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(CC)C(=O)N(C)C)CC1 WJLGIZVNZCLDIH-AKVZGJDWSA-N 0.000 claims 1
DAVPCRYBGNFETN-AIFRQZDJSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(CC)C(C)=O)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(CC)C(C)=O)CC1 DAVPCRYBGNFETN-AIFRQZDJSA-N 0.000 claims 1
MELOZMHGPBUJQN-TWDYDMQUSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(CC)S(C)(=O)=O)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(CC)S(C)(=O)=O)CC1 MELOZMHGPBUJQN-TWDYDMQUSA-N 0.000 claims 1
UXOPQYXSZARASH-IHDHMKHVSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)C(C)C)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)C(C)C)CC1 UXOPQYXSZARASH-IHDHMKHVSA-N 0.000 claims 1
SOQIVQVXODQKOH-BOANWVEESA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)CC(C)C)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)CC(C)C)CC1 SOQIVQVXODQKOH-BOANWVEESA-N 0.000 claims 1
CKRMTHWXSWZXBS-NZFRUTCLSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)CC)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)CC)CC1 CKRMTHWXSWZXBS-NZFRUTCLSA-N 0.000 claims 1
FRKOBZOXSFARTP-GYNNIAEXSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)N(C)C)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)N(C)C)CC1 FRKOBZOXSFARTP-GYNNIAEXSA-N 0.000 claims 1
INYDRJRTQPGLJK-BYCNXYFQSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NS(C)(=O)=O)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NS(C)(=O)=O)CC1 INYDRJRTQPGLJK-BYCNXYFQSA-N 0.000 claims 1
CNJDIPUBVSAEKF-WPUOIDIFSA-N [2-[7-[(2r)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorophenyl]urea Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)NC(N)=O)N1C1=CC=C(N(C)C)C=C1 CNJDIPUBVSAEKF-WPUOIDIFSA-N 0.000 claims 1
125000005189 alkyl hydroxy group Chemical group 0.000 claims 1
230000001028 anti-proliverative effect Effects 0.000 claims 1
125000004432 carbon atom Chemical group C* 0.000 claims 1
239000003795 chemical substances by application Substances 0.000 claims 1
125000004122 cyclic group Chemical group 0.000 claims 1
125000000753 cycloalkyl group Chemical group 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
TZTVTMGZQVEMTM-PGRZUCIQSA-N methyl (2s)-1-[(1s)-1-[4-[(1s)-1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]pyrrolidine-2-carboxylate Chemical compound COC(=O)[C@@H]1CCCN1[C@@H](C)C1=CC=C(N2C(CC3=CC(OC)=C(OC(C)C)C=C3[C@@H]2C=2C=CC(Cl)=CC=2)=O)C=C1 TZTVTMGZQVEMTM-PGRZUCIQSA-N 0.000 claims 1
VRMVNHJSHIHIKW-UHFFFAOYSA-N methyl 4-[1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]-3-(1,3-thiazol-5-ylmethoxy)benzoate Chemical compound C=1N=CSC=1COC1=CC(C(=O)OC)=CC=C1N(C(CC1=CC(OC)=C(OC(C)C)C=C11)=O)C1C1=CC=C(Cl)C=C1 VRMVNHJSHIHIKW-UHFFFAOYSA-N 0.000 claims 1
DDRYRORLOXFFJR-UHFFFAOYSA-N methyl 4-[1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]-3-(2h-tetrazol-5-ylmethoxy)benzoate Chemical compound N1=NNN=C1COC1=CC(C(=O)OC)=CC=C1N(C(CC1=CC(OC)=C(OC(C)C)C=C11)=O)C1C1=CC=C(Cl)C=C1 DDRYRORLOXFFJR-UHFFFAOYSA-N 0.000 claims 1
JYOYRUXXCYCZMF-UHFFFAOYSA-N methyl 4-[1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]-3-methoxybenzoate Chemical compound COC1=CC(C(=O)OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OC(C)C)C=C2C1C1=CC=C(Cl)C=C1 JYOYRUXXCYCZMF-UHFFFAOYSA-N 0.000 claims 1
150000004702 methyl esters Chemical class 0.000 claims 1
SANYBICWVNIEND-DHFMJDSQSA-N n-(2-aminoethyl)-n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)N(CCN)C(C)=O)C=C1 SANYBICWVNIEND-DHFMJDSQSA-N 0.000 claims 1
WNOSFBBENNYQOC-KGUSEGQSSA-N n-(3-aminopropyl)-n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)N(CCCN)C(C)=O)C=C1 WNOSFBBENNYQOC-KGUSEGQSSA-N 0.000 claims 1
YMCKBFUGFIAEDK-WJXDBAKQSA-N n-[(1r)-1-[4-[(1r)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-ethylacetamide Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C1=CC=C([C@@H](C)N(CC)C(C)=O)C=C1 YMCKBFUGFIAEDK-WJXDBAKQSA-N 0.000 claims 1
YMCKBFUGFIAEDK-PIFAPPPTSA-N n-[(1s)-1-[4-[(1r)-7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-ethylacetamide Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C1=CC=C([C@H](C)N(CC)C(C)=O)C=C1 YMCKBFUGFIAEDK-PIFAPPPTSA-N 0.000 claims 1
RNUWRMNKCXKTKT-GEFUHLBYSA-N n-[(1s)-1-[4-[(1s)-1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-2-(dimethylamino)acetamide Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@H](C)NC(=O)CN(C)C)=CC=C(Cl)C=C1 RNUWRMNKCXKTKT-GEFUHLBYSA-N 0.000 claims 1
ALJXVBYJZHWAKW-ADSBAMQRSA-N n-[(1s)-1-[4-[(1s)-1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-2-methoxyacetamide Chemical compound C1=CC([C@H](C)NC(=O)COC)=CC=C1N1C(=O)CC2=CC(OC)=C(OC(C)C)C=C2[C@@H]1C1=CC=C(Cl)C=C1 ALJXVBYJZHWAKW-ADSBAMQRSA-N 0.000 claims 1
JYVXYJKPEZKEFC-YRVHBCJASA-N n-[(1s)-1-[4-[(1s)-1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]acetamide Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@H](C)NC(C)=O)=CC=C(Cl)C=C1 JYVXYJKPEZKEFC-YRVHBCJASA-N 0.000 claims 1
NEFIWXAITYMWFC-DDVNXTKHSA-N n-[(3r)-1-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]pyrrolidin-3-yl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CC[C@@H](NC(C)=O)C1 NEFIWXAITYMWFC-DDVNXTKHSA-N 0.000 claims 1
TXXIBWMHDIDBPA-OVRCFHBYSA-N n-[(3s)-1-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]piperidin-3-yl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC[C@H](NC(C)=O)C1 TXXIBWMHDIDBPA-OVRCFHBYSA-N 0.000 claims 1
NEFIWXAITYMWFC-UXUDZYTPSA-N n-[(3s)-1-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]pyrrolidin-3-yl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CC[C@H](NC(C)=O)C1 NEFIWXAITYMWFC-UXUDZYTPSA-N 0.000 claims 1
KJXXFLDYJMPUJB-UHFFFAOYSA-N n-[1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-3-oxo-1,4-dihydroisoquinolin-7-yl]-2-methylpropanamide Chemical compound C12=CC(NC(=O)C(C)C)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 KJXXFLDYJMPUJB-UHFFFAOYSA-N 0.000 claims 1
PEYVYAMBSDFHAF-UHFFFAOYSA-N n-[1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-3-oxo-1,4-dihydroisoquinolin-7-yl]-n-propan-2-ylacetamide Chemical compound C12=CC(N(C(C)=O)C(C)C)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 PEYVYAMBSDFHAF-UHFFFAOYSA-N 0.000 claims 1
QIDKXFMFVFWYKZ-UHFFFAOYSA-N n-[1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-3-oxo-1,4-dihydroisoquinolin-7-yl]acetamide Chemical compound C=1C=C(N2C(CC3=CC=C(NC(C)=O)C=C3C2C=2C=CC(Cl)=CC=2)=O)C=CC=1N(C)CC1=CC=NC=C1 QIDKXFMFVFWYKZ-UHFFFAOYSA-N 0.000 claims 1
LXXWMRDUHMJDSX-UHFFFAOYSA-N n-[1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-3-oxo-1,4-dihydroisoquinolin-7-yl]propanamide Chemical compound C12=CC(NC(=O)CC)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 LXXWMRDUHMJDSX-UHFFFAOYSA-N 0.000 claims 1
WKPFGADMDMLPOJ-XFBJNOSPSA-N n-[1-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]piperidin-4-yl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC(NC(C)=O)CC1 WKPFGADMDMLPOJ-XFBJNOSPSA-N 0.000 claims 1
MDPBDRRLFSBADH-MHJPDIQUSA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-(2-methylpropyl)acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)N(CC(C)C)C(C)=O)C=C1 MDPBDRRLFSBADH-MHJPDIQUSA-N 0.000 claims 1
XRUNANKQUQZZNC-YFTDMWITSA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-(cyclohexylmethyl)acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)CC1CCCCC1 XRUNANKQUQZZNC-YFTDMWITSA-N 0.000 claims 1
LHNPXHSLMAUGIN-GJBZRHMXSA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-(cyclopentylmethyl)acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)CC1CCCC1 LHNPXHSLMAUGIN-GJBZRHMXSA-N 0.000 claims 1
ATKHBPCXKQWXSO-SELMQKCGSA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-(cyclopropylmethyl)acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)CC1CC1 ATKHBPCXKQWXSO-SELMQKCGSA-N 0.000 claims 1
ISZJXPGTOBQNAT-MHJPDIQUSA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-[2-(dimethylamino)ethyl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)N(CCN(C)C)C(C)=O)C=C1 ISZJXPGTOBQNAT-MHJPDIQUSA-N 0.000 claims 1
UHIZAMVQBHNXKL-BKCPDIIESA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-[3-(dimethylamino)propyl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)N(CCCN(C)C)C(C)=O)C=C1 UHIZAMVQBHNXKL-BKCPDIIESA-N 0.000 claims 1
BBVSSIWLUURIDP-SELMQKCGSA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-cyclobutylacetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)C1CCC1 BBVSSIWLUURIDP-SELMQKCGSA-N 0.000 claims 1
OOULIXIKZOCRBO-GJBZRHMXSA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-cyclohexylacetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)C1CCCCC1 OOULIXIKZOCRBO-GJBZRHMXSA-N 0.000 claims 1
CDFSEMCZAQDSNO-XFBJNOSPSA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-cyclopentylacetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)C1CCCC1 CDFSEMCZAQDSNO-XFBJNOSPSA-N 0.000 claims 1
YVAVCAKGUBEWEN-GGUFMPKBSA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-ethyl-1-methylpiperidine-3-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)C1CCCN(C)C1 YVAVCAKGUBEWEN-GGUFMPKBSA-N 0.000 claims 1
ULAMUJSRTJOWES-XHTYTWNBSA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-ethyl-1-methylpiperidine-4-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)C1CCN(C)CC1 ULAMUJSRTJOWES-XHTYTWNBSA-N 0.000 claims 1
KWECQJWBXPVDCV-IQEJMKLESA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-ethyl-1-methylpyrrolidine-3-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)C1CCN(C)C1 KWECQJWBXPVDCV-IQEJMKLESA-N 0.000 claims 1
YMCKBFUGFIAEDK-DHFMJDSQSA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-ethylacetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)N(CC)C(C)=O)C=C1 YMCKBFUGFIAEDK-DHFMJDSQSA-N 0.000 claims 1
CQVINMJHLMFOCD-BKCPDIIESA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-ethylpiperidine-4-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)C1CCNCC1 CQVINMJHLMFOCD-BKCPDIIESA-N 0.000 claims 1
MJEHQZBSRNQRJR-UXQVXNSPSA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-ethylpyrrolidine-3-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)C1CCNC1 MJEHQZBSRNQRJR-UXQVXNSPSA-N 0.000 claims 1
VGLGNSRSXLUAAG-XFBJNOSPSA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-piperidin-4-ylacetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)C1CCNCC1 VGLGNSRSXLUAAG-XFBJNOSPSA-N 0.000 claims 1
NPNGTASCYCHYIZ-KGUSEGQSSA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-propan-2-ylacetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)N(C(C)C)C(C)=O)C=C1 NPNGTASCYCHYIZ-KGUSEGQSSA-N 0.000 claims 1
XWCSRRFSBLBOIM-KGUSEGQSSA-N n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-n-propylacetamide Chemical compound C1=CC(C(C)N(CCC)C(C)=O)=CC=C1N1C(=O)CC2=CC(OC)=C(O[C@H](C)CC)C=C2C1C1=CC=C(Cl)C=C1 XWCSRRFSBLBOIM-KGUSEGQSSA-N 0.000 claims 1
CGHWWFPSIJEUJL-VITKDRCNSA-N n-[2-[7-[(2r)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorophenyl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)NC(C)=O)N1C1=CC=C(N(C)C)C=C1 CGHWWFPSIJEUJL-VITKDRCNSA-N 0.000 claims 1
JUYRXVSXIUFQOJ-MFUYNUFSSA-N n-[2-[7-[(2r)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorophenyl]propanamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)NC(=O)CC)N1C1=CC=C(N(C)C)C=C1 JUYRXVSXIUFQOJ-MFUYNUFSSA-N 0.000 claims 1
LWFLQMUHUMIQJZ-UHFFFAOYSA-N n-[2-[[1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-3-oxo-1,4-dihydroisoquinolin-7-yl]-propan-2-ylamino]ethyl]acetamide Chemical compound C12=CC(N(CCNC(C)=O)C(C)C)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 LWFLQMUHUMIQJZ-UHFFFAOYSA-N 0.000 claims 1
VJSBKCNOCNHASS-UHFFFAOYSA-N n-[4-[1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]phenyl]-2,2,2-trifluoro-n-methylacetamide Chemical compound C1=2C=C(OC(C)C)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C(=O)C(F)(F)F)C1C1=CC=C(Cl)C=C1 VJSBKCNOCNHASS-UHFFFAOYSA-N 0.000 claims 1
HCKIIIXWNXBFTC-PVFJFFHYSA-N n-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]-n-(cyclopentylmethyl)acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C(C)=O)CC1CCCC1 HCKIIIXWNXBFTC-PVFJFFHYSA-N 0.000 claims 1
VHKNQTVTMKLMIT-QHSQBYJISA-N n-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]-n-methylacetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C(C)=O)C=C1 VHKNQTVTMKLMIT-QHSQBYJISA-N 0.000 claims 1
KPVWHIFTYCQQON-WPUOIDIFSA-N n-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(NC(C)=O)C=C1 KPVWHIFTYCQQON-WPUOIDIFSA-N 0.000 claims 1
KEWVRNRHTOLMLI-UHFFFAOYSA-N n-[5-chloro-2-[6,7-diethoxy-2-(4-methoxyphenyl)-3-oxo-1,4-dihydroisoquinolin-1-yl]phenyl]acetamide Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C=CC(OC)=CC=2)C1C1=CC=C(Cl)C=C1NC(C)=O KEWVRNRHTOLMLI-UHFFFAOYSA-N 0.000 claims 1
APSINCLWOMYKMT-MFUYNUFSSA-N n-[[2-[7-[(2r)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorophenyl]methyl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)CNC(C)=O)N1C1=CC=C(N(C)C)C=C1 APSINCLWOMYKMT-MFUYNUFSSA-N 0.000 claims 1
FZSXPBWAGIQNPL-YFTDMWITSA-N n-benzyl-n-[1-[4-[7-[(2r)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)CC1=CC=CC=C1 FZSXPBWAGIQNPL-YFTDMWITSA-N 0.000 claims 1
125000001624 naphthyl group Chemical group 0.000 claims 1
125000004430 oxygen atom Chemical group O* 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 claims 1
125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 claims 1
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 1
125000006413 ring segment Chemical group 0.000 claims 1
125000004434 sulfur atom Chemical group 0.000 claims 1
239000000052 vinegar Substances 0.000 claims 1
0 CC(C)Oc1cc(C*(C(C2)=O)c(cc3)ccc3N(C)C)c2cc1OC Chemical compound CC(C)Oc1cc(C*(C(C2)=O)c(cc3)ccc3N(C)C)c2cc1OC 0.000 description 2
UAEPNZWRGJTJPN-UHFFFAOYSA-N CC1CCCCC1 Chemical compound CC1CCCCC1 UAEPNZWRGJTJPN-UHFFFAOYSA-N 0.000 description 1
PMDCZENCAXMSOU-UHFFFAOYSA-N CCNC(C)=O Chemical compound CCNC(C)=O PMDCZENCAXMSOU-UHFFFAOYSA-N 0.000 description 1

JP2012545293A 2009-12-22 2010-12-21 置換イソキノリノン類およびキナゾリノン類 Expired - Fee Related JP5542962B2 (ja)