JP2012532598A5 - - Google Patents
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- JP2012532598A5 JP2012532598A5 JP2012519063A JP2012519063A JP2012532598A5 JP 2012532598 A5 JP2012532598 A5 JP 2012532598A5 JP 2012519063 A JP2012519063 A JP 2012519063A JP 2012519063 A JP2012519063 A JP 2012519063A JP 2012532598 A5 JP2012532598 A5 JP 2012532598A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- regions
- light chain
- mammal
- constant region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 22
- 238000011144 upstream manufacturing Methods 0.000 claims 14
- 241000124008 Mammalia Species 0.000 claims 7
- 241000283984 Rodentia Species 0.000 claims 4
- 210000000628 antibody-producing cell Anatomy 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 238000003780 insertion Methods 0.000 claims 3
- 230000037431 insertion Effects 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000000349 chromosome Anatomy 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22396009P | 2009-07-08 | 2009-07-08 | |
| GB0911846.4 | 2009-07-08 | ||
| GBGB0911846.4A GB0911846D0 (en) | 2009-07-08 | 2009-07-08 | Animal models and therapeutic molecules |
| US61/223,960 | 2009-07-08 | ||
| GB0913102A GB0913102D0 (en) | 2009-07-28 | 2009-07-28 | Animal models and therapeutic molesules |
| GB0913102.0 | 2009-07-28 | ||
| US35566610P | 2010-06-17 | 2010-06-17 | |
| US61/355,666 | 2010-06-17 | ||
| PCT/GB2010/051122 WO2011004192A1 (en) | 2009-07-08 | 2010-07-07 | Animal models and therapeutic molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015022430A Division JP6088562B2 (ja) | 2009-07-08 | 2015-02-06 | 動物モデルおよび治療用分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012532598A JP2012532598A (ja) | 2012-12-20 |
| JP2012532598A5 true JP2012532598A5 (https=) | 2014-01-23 |
| JP5944312B2 JP5944312B2 (ja) | 2016-07-05 |
Family
ID=43428834
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519063A Active JP5944312B2 (ja) | 2009-07-08 | 2010-07-07 | 動物モデルおよび治療用分子 |
| JP2015022430A Active JP6088562B2 (ja) | 2009-07-08 | 2015-02-06 | 動物モデルおよび治療用分子 |
| JP2017017360A Active JP6612275B2 (ja) | 2009-07-08 | 2017-02-02 | 動物モデルおよび治療用分子 |
| JP2019197622A Active JP6930695B2 (ja) | 2009-07-08 | 2019-10-30 | 動物モデルおよび治療用分子 |
| JP2020102977A Active JP7141427B2 (ja) | 2009-07-08 | 2020-06-15 | 動物モデルおよび治療用分子 |
| JP2020102978A Expired - Fee Related JP6876854B2 (ja) | 2009-07-08 | 2020-06-15 | 動物モデルおよび治療用分子 |
| JP2020102976A Active JP6876853B2 (ja) | 2009-07-08 | 2020-06-15 | 動物モデルおよび治療用分子 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015022430A Active JP6088562B2 (ja) | 2009-07-08 | 2015-02-06 | 動物モデルおよび治療用分子 |
| JP2017017360A Active JP6612275B2 (ja) | 2009-07-08 | 2017-02-02 | 動物モデルおよび治療用分子 |
| JP2019197622A Active JP6930695B2 (ja) | 2009-07-08 | 2019-10-30 | 動物モデルおよび治療用分子 |
| JP2020102977A Active JP7141427B2 (ja) | 2009-07-08 | 2020-06-15 | 動物モデルおよび治療用分子 |
| JP2020102978A Expired - Fee Related JP6876854B2 (ja) | 2009-07-08 | 2020-06-15 | 動物モデルおよび治療用分子 |
| JP2020102976A Active JP6876853B2 (ja) | 2009-07-08 | 2020-06-15 | 動物モデルおよび治療用分子 |
Country Status (22)
| Country | Link |
|---|---|
| US (33) | US20120204278A1 (https=) |
| EP (19) | EP2604111A3 (https=) |
| JP (7) | JP5944312B2 (https=) |
| KR (1) | KR101875233B1 (https=) |
| CN (2) | CN102638971B (https=) |
| AU (4) | AU2010269978B2 (https=) |
| BR (1) | BR112012000536A2 (https=) |
| CA (1) | CA2767436A1 (https=) |
| CY (1) | CY1126083T1 (https=) |
| DK (12) | DK3622815T3 (https=) |
| ES (10) | ES2884309T3 (https=) |
| HR (2) | HRP20130253T1 (https=) |
| HU (2) | HUE061788T2 (https=) |
| LT (1) | LT3241435T (https=) |
| NO (1) | NO2792236T3 (https=) |
| NZ (1) | NZ597481A (https=) |
| PL (4) | PL2421357T3 (https=) |
| PT (4) | PT3241435T (https=) |
| SG (2) | SG177380A1 (https=) |
| SI (2) | SI3241435T1 (https=) |
| SM (1) | SMT201300046B (https=) |
| WO (1) | WO2011004192A1 (https=) |
Families Citing this family (135)
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| SMT202600080T1 (it) | 2010-02-08 | 2026-03-09 | Regeneron Pharma | Topo con catena leggera comune |
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| CN103025884B (zh) | 2010-07-26 | 2015-11-25 | 特里安尼公司 | 转基因动物和使用方法 |
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