JP2020530760A5 - - Google Patents
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- Publication number
- JP2020530760A5 JP2020530760A5 JP2020500127A JP2020500127A JP2020530760A5 JP 2020530760 A5 JP2020530760 A5 JP 2020530760A5 JP 2020500127 A JP2020500127 A JP 2020500127A JP 2020500127 A JP2020500127 A JP 2020500127A JP 2020530760 A5 JP2020530760 A5 JP 2020530760A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- cell
- domain
- heavy chain
- locus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1710984.4 | 2017-07-07 | ||
| GBGB1710984.4A GB201710984D0 (en) | 2017-07-07 | 2017-07-07 | Cells, vertebrates, populations & methods |
| PCT/EP2018/068309 WO2019008123A2 (en) | 2017-07-07 | 2018-07-05 | CELLS, VERTEBRATES, POPULATIONS AND METHODS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020530760A JP2020530760A (ja) | 2020-10-29 |
| JP2020530760A5 true JP2020530760A5 (https=) | 2021-08-12 |
| JP7288892B2 JP7288892B2 (ja) | 2023-06-08 |
Family
ID=59676641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020500127A Active JP7288892B2 (ja) | 2017-07-07 | 2018-07-05 | 細胞、脊椎動物、集団及び方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20200214274A1 (https=) |
| EP (2) | EP4410986A3 (https=) |
| JP (1) | JP7288892B2 (https=) |
| ES (1) | ES2986443T3 (https=) |
| GB (1) | GB201710984D0 (https=) |
| HU (1) | HUE068193T2 (https=) |
| PL (1) | PL3648587T3 (https=) |
| TW (1) | TWI820030B (https=) |
| WO (1) | WO2019008123A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3622815T3 (da) | 2009-07-08 | 2023-06-26 | Kymab Ltd | Gnavermodeller og terapeutiske molekyler |
| BR112014006394A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| AU2014330922A1 (en) | 2013-10-01 | 2016-03-03 | Kymab Limited | Animal models and therapeutic molecules |
| HUE060608T2 (hu) * | 2017-12-05 | 2023-03-28 | Regeneron Pharma | Genetikailag módosított immunglobulin lambda könnyûlánccal rendelkezõ egerek és azok alkalmazása |
| CA3125380A1 (en) | 2019-02-18 | 2020-08-27 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with humanized immunoglobulin locus |
| GB2590642B (en) * | 2019-12-20 | 2024-02-14 | Kymab Ltd | Improved lambda antibodies |
| CN113939541A (zh) * | 2019-05-15 | 2022-01-14 | 科马布有限公司 | 改进的λ抗体 |
| MX2021014893A (es) * | 2019-06-05 | 2022-03-11 | Regeneron Pharma | Animales no humanos que tienen un repertorio de cadena ligera lambda limitado expresado a partir del locus kappa y usos de estos. |
| JP2023529846A (ja) * | 2020-06-02 | 2023-07-12 | バイオサイトジェン ファーマシューティカルズ （ベイジン） カンパニー リミテッド | 共通軽鎖免疫グロブリン遺伝子座を有する遺伝子改変非ヒト動物 |
| US20220090060A1 (en) | 2020-09-11 | 2022-03-24 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| CN116848254B (zh) | 2020-12-16 | 2026-03-17 | 瑞泽恩制药公司 | 表达人源化Fcα受体的小鼠 |
| GB202107372D0 (en) | 2021-05-24 | 2021-07-07 | Petmedix Ltd | Animal models and therapeutics molecules |
| GB202209247D0 (en) | 2022-06-23 | 2022-08-10 | Petmedix Ltd | Animal models and therapeutic molecules |
| GB202216503D0 (en) | 2022-11-05 | 2022-12-21 | Quadrucept Bio Ltd | Non-human vertebrates & cells |
| GB202217978D0 (en) | 2022-11-30 | 2023-01-11 | Petmedix Ltd | Rodents expressing a common light chain |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| WO2026035843A2 (en) | 2024-08-06 | 2026-02-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041871B1 (en) * | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| ATE299938T1 (de) | 1997-05-02 | 2005-08-15 | Genentech Inc | Ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen |
| DK2314629T4 (da) * | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
| AU2006242854A1 (en) * | 2005-04-29 | 2006-11-09 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Transgenic animals and methods of making recombinant antibodies |
| EP2147594B1 (en) * | 2008-06-27 | 2013-11-13 | Merus B.V. | Antibody producing non-human mammals |
| SMT202600080T1 (it) * | 2010-02-08 | 2026-03-09 | Regeneron Pharma | Topo con catena leggera comune |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US9253965B2 (en) * | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| MY178882A (en) * | 2013-02-20 | 2020-10-21 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
| HK1218550A1 (zh) | 2013-03-13 | 2017-02-24 | Regeneron Pharmaceuticals, Inc. | 常見輕鏈小鼠 |
| GB201316644D0 (en) | 2013-09-19 | 2013-11-06 | Kymab Ltd | Expression vector production & High-Throughput cell screening |
-
2017
- 2017-07-07 GB GBGB1710984.4A patent/GB201710984D0/en not_active Ceased
-
2018
- 2018-07-05 HU HUE18743421A patent/HUE068193T2/hu unknown
- 2018-07-05 EP EP24178098.0A patent/EP4410986A3/en active Pending
- 2018-07-05 PL PL18743421.2T patent/PL3648587T3/pl unknown
- 2018-07-05 ES ES18743421T patent/ES2986443T3/es active Active
- 2018-07-05 JP JP2020500127A patent/JP7288892B2/ja active Active
- 2018-07-05 WO PCT/EP2018/068309 patent/WO2019008123A2/en not_active Ceased
- 2018-07-05 EP EP18743421.2A patent/EP3648587B8/en active Active
- 2018-07-06 TW TW107123525A patent/TWI820030B/zh active
-
2019
- 2019-12-19 US US16/721,326 patent/US20200214274A1/en active Pending
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