JP2020530760A5 - - Google Patents
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- Publication number
- JP2020530760A5 JP2020530760A5 JP2020500127A JP2020500127A JP2020530760A5 JP 2020530760 A5 JP2020530760 A5 JP 2020530760A5 JP 2020500127 A JP2020500127 A JP 2020500127A JP 2020500127 A JP2020500127 A JP 2020500127A JP 2020530760 A5 JP2020530760 A5 JP 2020530760A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- cell
- domain
- heavy chain
- locus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1710984.4A GB201710984D0 (en) | 2017-07-07 | 2017-07-07 | Cells, vertebrates, populations & methods |
| GB1710984.4 | 2017-07-07 | ||
| PCT/EP2018/068309 WO2019008123A2 (en) | 2017-07-07 | 2018-07-05 | CELLS, VERTEBRATES, POPULATIONS AND METHODS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020530760A JP2020530760A (ja) | 2020-10-29 |
| JP2020530760A5 true JP2020530760A5 (https=) | 2021-08-12 |
| JP7288892B2 JP7288892B2 (ja) | 2023-06-08 |
Family
ID=59676641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020500127A Active JP7288892B2 (ja) | 2017-07-07 | 2018-07-05 | 細胞、脊椎動物、集団及び方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20200214274A1 (https=) |
| EP (2) | EP3648587B8 (https=) |
| JP (1) | JP7288892B2 (https=) |
| ES (1) | ES2986443T3 (https=) |
| GB (1) | GB201710984D0 (https=) |
| HU (1) | HUE068193T2 (https=) |
| PL (1) | PL3648587T3 (https=) |
| TW (1) | TWI820030B (https=) |
| WO (1) | WO2019008123A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012000536A2 (pt) | 2009-07-08 | 2020-08-11 | Kymab Limited | métodos para produção de anticorpo ou cadeia leve ou pesada de anticorpo específico para um antígeno desejado, para produção de anticorpo ou cadeia de anticorpo e seu uso, composição farmacêutica e derivado de anticorpo quimérico |
| BR112014006394A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| DE112014004537T5 (de) | 2013-10-01 | 2016-07-21 | Kymab Limited | Tiermodelle und therapeutische Moleküle |
| DK4140297T3 (da) * | 2017-12-05 | 2025-06-23 | Regeneron Pharma | Mus med en konstrueret immunglobulin-lambda-letkæde og anvendelser deraf |
| EP3927832A4 (en) | 2019-02-18 | 2022-11-30 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | GENETICALLY MODIFIED NON-HUMAN ANIMALS WITH HUMANIZED IMMUNOGLOBULIN LOCUS |
| US20230250192A1 (en) * | 2019-05-15 | 2023-08-10 | Kymab Limited | Improved lambda antibodies |
| GB2590642B (en) * | 2019-12-20 | 2024-02-14 | Kymab Ltd | Improved lambda antibodies |
| SG11202111258TA (en) * | 2019-06-05 | 2021-11-29 | Regeneron Pharma | Non-human animals having a limited lambda light chain repertoire expressed from the kappa locus and uses thereof |
| KR20230018439A (ko) * | 2020-06-02 | 2023-02-07 | 바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 | 공동 경쇄 면역글로불린 좌위를 갖는 유전자 변형 비인간 동물 |
| CA3187680A1 (en) | 2020-09-11 | 2022-03-17 | Yashu Liu | Identification and production of antigen-specific antibodies |
| WO2022132943A1 (en) | 2020-12-16 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| GB202107372D0 (en) | 2021-05-24 | 2021-07-07 | Petmedix Ltd | Animal models and therapeutics molecules |
| GB202209247D0 (en) | 2022-06-23 | 2022-08-10 | Petmedix Ltd | Animal models and therapeutic molecules |
| GB202216503D0 (en) | 2022-11-05 | 2022-12-21 | Quadrucept Bio Ltd | Non-human vertebrates & cells |
| GB202217978D0 (en) | 2022-11-30 | 2023-01-11 | Petmedix Ltd | Rodents expressing a common light chain |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| WO2026035843A2 (en) | 2024-08-06 | 2026-02-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041871B1 (en) * | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| JP4213224B2 (ja) | 1997-05-02 | 2009-01-21 | ジェネンテック，インコーポレーテッド | ヘテロマルチマー及び共通成分を有する多重特異性抗体の製造方法 |
| NZ537277A (en) * | 2002-07-18 | 2008-04-30 | Crucell Holland Bv | Recombinant production of mixtures of antibodies |
| ES2408582T3 (es) * | 2003-05-30 | 2013-06-21 | Merus B.V. | Biblioteca de Fab para la preparación de una mezcla de anticuerpos |
| JP2008538912A (ja) * | 2005-04-29 | 2008-11-13 | イナート・ファルマ | 遺伝子導入動物および組換え抗体の製造方法 |
| PL3456190T3 (pl) * | 2008-06-27 | 2022-06-06 | Merus N.V. | Wytwarzające przeciwciała transgeniczne zwierzę z gatunku myszy |
| SI2501817T2 (sl) * | 2010-02-08 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Miš z navadno lahko verigo |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US9253965B2 (en) * | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| EP2840892B1 (en) * | 2013-02-20 | 2018-04-18 | Regeneron Pharmaceuticals, Inc. | Non-human animals with modified immunoglobulin heavy chain sequences |
| CN105189545A (zh) | 2013-03-13 | 2015-12-23 | 瑞泽恩制药公司 | 常见轻链小鼠 |
| GB201316644D0 (en) | 2013-09-19 | 2013-11-06 | Kymab Ltd | Expression vector production & High-Throughput cell screening |
-
2017
- 2017-07-07 GB GBGB1710984.4A patent/GB201710984D0/en not_active Ceased
-
2018
- 2018-07-05 JP JP2020500127A patent/JP7288892B2/ja active Active
- 2018-07-05 WO PCT/EP2018/068309 patent/WO2019008123A2/en not_active Ceased
- 2018-07-05 PL PL18743421.2T patent/PL3648587T3/pl unknown
- 2018-07-05 HU HUE18743421A patent/HUE068193T2/hu unknown
- 2018-07-05 ES ES18743421T patent/ES2986443T3/es active Active
- 2018-07-05 EP EP18743421.2A patent/EP3648587B8/en active Active
- 2018-07-05 EP EP24178098.0A patent/EP4410986A3/en active Pending
- 2018-07-06 TW TW107123525A patent/TWI820030B/zh active
-
2019
- 2019-12-19 US US16/721,326 patent/US20200214274A1/en active Pending
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