JP2014110814A5 - - Google Patents
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- JP2014110814A5 JP2014110814A5 JP2014057616A JP2014057616A JP2014110814A5 JP 2014110814 A5 JP2014110814 A5 JP 2014110814A5 JP 2014057616 A JP2014057616 A JP 2014057616A JP 2014057616 A JP2014057616 A JP 2014057616A JP 2014110814 A5 JP2014110814 A5 JP 2014110814A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- mouse
- gene
- gene segment
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims 89
- 210000004027 cell Anatomy 0.000 claims 23
- 238000003780 insertion Methods 0.000 claims 14
- 230000037431 insertion Effects 0.000 claims 14
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 7
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical group 0.000 claims 7
- 210000003719 b-lymphocyte Anatomy 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 210000004408 hybridoma Anatomy 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 238000011144 upstream manufacturing Methods 0.000 claims 4
- 210000001161 mammalian embryo Anatomy 0.000 claims 3
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161446895P | 2011-02-25 | 2011-02-25 | |
| US61/446,895 | 2011-02-25 | ||
| US201161497650P | 2011-06-16 | 2011-06-16 | |
| US61/497,650 | 2011-06-16 | ||
| US201261595200P | 2012-02-06 | 2012-02-06 | |
| US61/595,200 | 2012-02-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013550677A Division JP2014507137A (ja) | 2011-02-25 | 2012-02-24 | Ａｄａｍ６マウス |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015036588A Division JP2015107131A (ja) | 2011-02-25 | 2015-02-26 | Ａｄａｍ６マウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014110814A JP2014110814A (ja) | 2014-06-19 |
| JP2014110814A5 true JP2014110814A5 (https=) | 2015-04-09 |
| JP5866127B2 JP5866127B2 (ja) | 2016-02-17 |
Family
ID=45998616
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013550677A Pending JP2014507137A (ja) | 2011-02-25 | 2012-02-24 | Ａｄａｍ６マウス |
| JP2014057616A Active JP5866127B2 (ja) | 2011-02-25 | 2014-03-20 | Ａｄａｍ６マウス |
| JP2015036588A Withdrawn JP2015107131A (ja) | 2011-02-25 | 2015-02-26 | Ａｄａｍ６マウス |
| JP2016088848A Withdrawn JP2016135143A (ja) | 2011-02-25 | 2016-04-27 | Ａｄａｍ６マウス |
| JP2018107070A Withdrawn JP2018143250A (ja) | 2011-02-25 | 2018-06-04 | Ａｄａｍ６マウス |
| JP2019127562A Withdrawn JP2019187446A (ja) | 2011-02-25 | 2019-07-09 | Ａｄａｍ６マウス |
| JP2022029501A Pending JP2022071051A (ja) | 2011-02-25 | 2022-02-28 | Ａｄａｍ６マウス |
| JP2024212173A Pending JP2025032218A (ja) | 2011-02-25 | 2024-12-05 | Ａｄａｍ６マウス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013550677A Pending JP2014507137A (ja) | 2011-02-25 | 2012-02-24 | Ａｄａｍ６マウス |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015036588A Withdrawn JP2015107131A (ja) | 2011-02-25 | 2015-02-26 | Ａｄａｍ６マウス |
| JP2016088848A Withdrawn JP2016135143A (ja) | 2011-02-25 | 2016-04-27 | Ａｄａｍ６マウス |
| JP2018107070A Withdrawn JP2018143250A (ja) | 2011-02-25 | 2018-06-04 | Ａｄａｍ６マウス |
| JP2019127562A Withdrawn JP2019187446A (ja) | 2011-02-25 | 2019-07-09 | Ａｄａｍ６マウス |
| JP2022029501A Pending JP2022071051A (ja) | 2011-02-25 | 2022-02-28 | Ａｄａｍ６マウス |
| JP2024212173A Pending JP2025032218A (ja) | 2011-02-25 | 2024-12-05 | Ａｄａｍ６マウス |
Country Status (31)
| Country | Link |
|---|---|
| US (12) | US8642835B2 (https=) |
| EP (7) | EP2738258B2 (https=) |
| JP (8) | JP2014507137A (https=) |
| KR (1) | KR101387377B1 (https=) |
| CN (2) | CN103429746B (https=) |
| AU (6) | AU2012243291B2 (https=) |
| BR (1) | BR112013021771B1 (https=) |
| CA (1) | CA2820824A1 (https=) |
| CY (5) | CY1116301T1 (https=) |
| DE (5) | DE14176593T1 (https=) |
| DK (6) | DK2578688T4 (https=) |
| ES (6) | ES2748832T5 (https=) |
| FI (3) | FI2578688T4 (https=) |
| HR (5) | HRP20192311T4 (https=) |
| HU (5) | HUE046746T2 (https=) |
| IL (4) | IL226727A (https=) |
| IN (1) | IN2013CN07629A (https=) |
| LT (4) | LT2738258T (https=) |
| ME (3) | ME02106B (https=) |
| MX (3) | MX343009B (https=) |
| MY (1) | MY172713A (https=) |
| NZ (3) | NZ731926A (https=) |
| PL (5) | PL4067496T3 (https=) |
| PT (5) | PT2550363E (https=) |
| RS (5) | RS64280B1 (https=) |
| RU (2) | RU2722373C2 (https=) |
| SG (4) | SG10201913160QA (https=) |
| SI (5) | SI2578688T2 (https=) |
| SM (5) | SMT201900581T1 (https=) |
| WO (1) | WO2012141798A1 (https=) |
| ZA (1) | ZA201305998B (https=) |
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| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
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| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| DK2314629T4 (da) | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| KR101151957B1 (ko) | 2004-07-22 | 2012-06-01 | 로저 킹돈 크레이그 | 결합 분자 |
| GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| DK3622815T3 (da) | 2009-07-08 | 2023-06-26 | Kymab Ltd | Gnavermodeller og terapeutiske molekyler |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
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| SG11201401181YA (en) * | 2011-10-17 | 2014-04-28 | Regeneron Pharma | Restricted immunoglobulin heavy chain mice |
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| US20180295821A1 (en) * | 2011-12-02 | 2018-10-18 | Kymab Limited | Transgenic Animals |
| SG10201605675WA (en) | 2011-12-20 | 2016-09-29 | Regeneron Pharma | Humanized light chain mice |
| EP3597038B1 (en) * | 2012-02-01 | 2021-04-21 | Regeneron Pharmaceuticals, Inc. | Humanized rodents that express heavy chains containing vl domains |
| WO2013138681A1 (en) | 2012-03-16 | 2013-09-19 | Regeneron Pharmaceuticals, Inc. | Mice that produce antigen-binding proteins with ph-dependent binding characteristics |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| EP2825036B1 (en) | 2012-03-16 | 2018-05-02 | Regeneron Pharmaceuticals, Inc. | Histidine engineered light chain antibodies and genetically modified rodents for generating the same |
| EP3539374A1 (en) | 2012-03-16 | 2019-09-18 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing ph-sensitive immunoglobulin sequences |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
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