JP2014110814A5 - - Google Patents
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- JP2014110814A5 JP2014110814A5 JP2014057616A JP2014057616A JP2014110814A5 JP 2014110814 A5 JP2014110814 A5 JP 2014110814A5 JP 2014057616 A JP2014057616 A JP 2014057616A JP 2014057616 A JP2014057616 A JP 2014057616A JP 2014110814 A5 JP2014110814 A5 JP 2014110814A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- mouse
- gene
- gene segment
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims 89
- 210000004027 cell Anatomy 0.000 claims 23
- 238000003780 insertion Methods 0.000 claims 14
- 230000037431 insertion Effects 0.000 claims 14
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 7
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical group 0.000 claims 7
- 210000003719 b-lymphocyte Anatomy 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 210000004408 hybridoma Anatomy 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 238000011144 upstream manufacturing Methods 0.000 claims 4
- 210000001161 mammalian embryo Anatomy 0.000 claims 3
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161446895P | 2011-02-25 | 2011-02-25 | |
| US61/446,895 | 2011-02-25 | ||
| US201161497650P | 2011-06-16 | 2011-06-16 | |
| US61/497,650 | 2011-06-16 | ||
| US201261595200P | 2012-02-06 | 2012-02-06 | |
| US61/595,200 | 2012-02-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013550677A Division JP2014507137A (ja) | 2011-02-25 | 2012-02-24 | Ａｄａｍ６マウス |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015036588A Division JP2015107131A (ja) | 2011-02-25 | 2015-02-26 | Ａｄａｍ６マウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014110814A JP2014110814A (ja) | 2014-06-19 |
| JP2014110814A5 true JP2014110814A5 (https=) | 2015-04-09 |
| JP5866127B2 JP5866127B2 (ja) | 2016-02-17 |
Family
ID=45998616
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013550677A Pending JP2014507137A (ja) | 2011-02-25 | 2012-02-24 | Ａｄａｍ６マウス |
| JP2014057616A Active JP5866127B2 (ja) | 2011-02-25 | 2014-03-20 | Ａｄａｍ６マウス |
| JP2015036588A Withdrawn JP2015107131A (ja) | 2011-02-25 | 2015-02-26 | Ａｄａｍ６マウス |
| JP2016088848A Withdrawn JP2016135143A (ja) | 2011-02-25 | 2016-04-27 | Ａｄａｍ６マウス |
| JP2018107070A Withdrawn JP2018143250A (ja) | 2011-02-25 | 2018-06-04 | Ａｄａｍ６マウス |
| JP2019127562A Withdrawn JP2019187446A (ja) | 2011-02-25 | 2019-07-09 | Ａｄａｍ６マウス |
| JP2022029501A Pending JP2022071051A (ja) | 2011-02-25 | 2022-02-28 | Ａｄａｍ６マウス |
| JP2024212173A Pending JP2025032218A (ja) | 2011-02-25 | 2024-12-05 | Ａｄａｍ６マウス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013550677A Pending JP2014507137A (ja) | 2011-02-25 | 2012-02-24 | Ａｄａｍ６マウス |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015036588A Withdrawn JP2015107131A (ja) | 2011-02-25 | 2015-02-26 | Ａｄａｍ６マウス |
| JP2016088848A Withdrawn JP2016135143A (ja) | 2011-02-25 | 2016-04-27 | Ａｄａｍ６マウス |
| JP2018107070A Withdrawn JP2018143250A (ja) | 2011-02-25 | 2018-06-04 | Ａｄａｍ６マウス |
| JP2019127562A Withdrawn JP2019187446A (ja) | 2011-02-25 | 2019-07-09 | Ａｄａｍ６マウス |
| JP2022029501A Pending JP2022071051A (ja) | 2011-02-25 | 2022-02-28 | Ａｄａｍ６マウス |
| JP2024212173A Pending JP2025032218A (ja) | 2011-02-25 | 2024-12-05 | Ａｄａｍ６マウス |
Country Status (31)
| Country | Link |
|---|---|
| US (12) | US8642835B2 (https=) |
| EP (7) | EP2738258B2 (https=) |
| JP (8) | JP2014507137A (https=) |
| KR (1) | KR101387377B1 (https=) |
| CN (2) | CN103429746B (https=) |
| AU (6) | AU2012243291B2 (https=) |
| BR (1) | BR112013021771B1 (https=) |
| CA (1) | CA2820824A1 (https=) |
| CY (5) | CY1116301T1 (https=) |
| DE (5) | DE12192727T1 (https=) |
| DK (6) | DK2578688T4 (https=) |
| ES (6) | ES2748832T5 (https=) |
| FI (3) | FI2738258T4 (https=) |
| HR (5) | HRP20191895T4 (https=) |
| HU (5) | HUE047687T2 (https=) |
| IL (4) | IL226727A (https=) |
| IN (1) | IN2013CN07629A (https=) |
| LT (4) | LT2578688T (https=) |
| ME (3) | ME02106B (https=) |
| MX (3) | MX375115B (https=) |
| MY (1) | MY172713A (https=) |
| NZ (3) | NZ813867A (https=) |
| PL (5) | PL2738259T3 (https=) |
| PT (5) | PT2550363E (https=) |
| RS (5) | RS59661B2 (https=) |
| RU (2) | RU2722373C2 (https=) |
| SG (4) | SG10201405135RA (https=) |
| SI (5) | SI2578688T2 (https=) |
| SM (5) | SMT202300173T1 (https=) |
| WO (1) | WO2012141798A1 (https=) |
| ZA (1) | ZA201305998B (https=) |
Families Citing this family (91)
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| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| NZ537277A (en) | 2002-07-18 | 2008-04-30 | Crucell Holland Bv | Recombinant production of mixtures of antibodies |
| ES2408582T3 (es) | 2003-05-30 | 2013-06-21 | Merus B.V. | Biblioteca de Fab para la preparación de una mezcla de anticuerpos |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| SI2311874T1 (sl) | 2004-07-22 | 2017-12-29 | Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics | Vezavne molekule |
| GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| BR112012000536A2 (pt) * | 2009-07-08 | 2020-08-11 | Kymab Limited | métodos para produção de anticorpo ou cadeia leve ou pesada de anticorpo específico para um antígeno desejado, para produção de anticorpo ou cadeia de anticorpo e seu uso, composição farmacêutica e derivado de anticorpo quimérico |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| SI2501817T2 (sl) | 2010-02-08 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Miš z navadno lahko verigo |
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| RU2722373C2 (ru) | 2011-02-25 | 2020-05-29 | Редженерон Фармасьютикалс, Инк. | Мыши adam6 |
| EP2739300B1 (en) | 2011-07-05 | 2019-06-19 | Duke University | N-terminal deleted gp120 immunogens |
| RS59728B1 (sr) * | 2011-08-05 | 2020-02-28 | Regeneron Pharma | Humanizovani miševi univerzalnog lakog lanca |
| WO2013041845A2 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Animals, repertoires & methods |
| BR112014006394A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos |
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| CA2850745C (en) | 2011-10-03 | 2022-12-13 | Duke University | Vaccine |
| KR20160098514A (ko) | 2011-10-17 | 2016-08-18 | 리제너론 파아마슈티컬스, 인크. | 제한된 면역글로불린 중쇄 마우스 |
| GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| US20180295821A1 (en) * | 2011-12-02 | 2018-10-18 | Kymab Limited | Transgenic Animals |
| RU2664181C2 (ru) | 2011-12-20 | 2018-08-15 | Регенерон Фармасьютикалз, Инк. | Мыши с гуманизированной легкой цепью |
| RS62023B1 (sr) * | 2012-02-01 | 2021-07-30 | Regeneron Pharma | Humanizovani glodari koji eksprimiraju teške lance koji sadrže vl domene |
| MX2014011047A (es) | 2012-03-16 | 2015-04-08 | Regeneron Pharma | Ratones que producen proteinas de union a un antigeno con caracteristicas de union dependientes del ph. |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| SG10201700360VA (en) | 2012-03-16 | 2017-03-30 | Regeneron Pharma | Non-human animals expressing ph-sensitive immunoglobulin sequences |
| KR102228296B1 (ko) | 2012-03-16 | 2021-03-17 | 리제너론 파마슈티칼스 인코포레이티드 | 히스티딘 공학처리된 경쇄 항체 및 그것을 생성하기 위한 유전자 변형된 비-사람 동물 |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| SI2838917T1 (sl) | 2012-04-20 | 2019-11-29 | Merus Nv | Postopki in sredstva za produkcijo heterodimernih IG-podobnih molekul |
| PT3597037T (pt) | 2012-06-12 | 2021-06-01 | Regeneron Pharma | Animais não humanos humanizados com lócus de cadeia pesada de imunoglobulina restrito |
| KR20150115775A (ko) | 2013-02-06 | 2015-10-14 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 동물을 이용한 b 세포 계통 기반의 면역원 설계 |
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