MX375115B - Ratones de una desintegrina y metaloproteasa 6 (adam6). - Google Patents

Ratones de una desintegrina y metaloproteasa 6 (adam6).

Info

Publication number
MX375115B
MX375115B MX2016013717A MX2016013717A MX375115B MX 375115 B MX375115 B MX 375115B MX 2016013717 A MX2016013717 A MX 2016013717A MX 2016013717 A MX2016013717 A MX 2016013717A MX 375115 B MX375115 B MX 375115B
Authority
MX
Mexico
Prior art keywords
adam6
mice
sequence
mouse
ortholog
Prior art date
Application number
MX2016013717A
Other languages
English (en)
Inventor
Andrew J Murphy
Lynn Macdonald
Sean Stevens
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45998616&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX375115(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX375115B publication Critical patent/MX375115B/es

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
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Abstract

Se proporcionan ratones que comprenden una reducción o eliminación de actividad ADAM6 a partir de un locus de ADAM6 endógeno, o que carecen de un locus endógeno que codifica una proteína ADAM6 de ratón, en donde los ratones comprenden una secuencia que codifica un ADAM6 u ortólogo u homólogo o fragmento del mismo, que es funcional en un ratón macho. En una modalidad, la secuencia es una secuencia ectópica de ADAM6 o una secuencia que le confiere a un ratón macho la capacidad de generar descendencia por apareamiento. También se proporcionan ratones y células con loci de cadena pesada de inmunoglobulina genéticamente modificados, que comprenden una secuencia ectópica de nucléotidos que codifica un ADAM6 de ratón o fragmento funcional u homólogo u ortólogo del mismo.
MX2016013717A 2011-02-25 2012-02-24 Ratones de una desintegrina y metaloproteasa 6 (adam6). MX375115B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161446895P 2011-02-25 2011-02-25
US201161497650P 2011-06-16 2011-06-16
US201261595200P 2012-02-06 2012-02-06
PCT/US2012/026416 WO2012141798A1 (en) 2011-02-25 2012-02-24 Adam6 mice

Publications (1)

Publication Number Publication Date
MX375115B true MX375115B (es) 2025-03-06

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MX2013009649A MX343009B (es) 2011-02-25 2012-02-24 Ratones de una desintegrina y metaloproteasa 6 (adam6).
MX2016013717A MX375115B (es) 2011-02-25 2012-02-24 Ratones de una desintegrina y metaloproteasa 6 (adam6).
MX2020009714A MX2020009714A (es) 2011-02-25 2013-08-21 Ratones de una desintegrina y metaloproteasa 6 (adam6).

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MX2013009649A MX343009B (es) 2011-02-25 2012-02-24 Ratones de una desintegrina y metaloproteasa 6 (adam6).

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MX2020009714A MX2020009714A (es) 2011-02-25 2013-08-21 Ratones de una desintegrina y metaloproteasa 6 (adam6).

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EP (7) EP2550363B1 (es)
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EP2738258B1 (en) 2019-09-25
ES2758974T3 (es) 2020-05-07
HUE046081T2 (hu) 2020-01-28
NZ718688A (en) 2017-07-28
AU2022206806B2 (en) 2025-10-02
ES2946169T3 (es) 2023-07-13
EP3744850A1 (en) 2020-12-02
US10694725B2 (en) 2020-06-30
US9944716B2 (en) 2018-04-17
RS59413B2 (sr) 2023-06-30
SI2738258T2 (sl) 2023-05-31
PT2550363E (pt) 2015-03-16
SMT201500061B (it) 2015-05-05
EP2813573A1 (en) 2014-12-17
KR20130116375A (ko) 2013-10-23
US20180362663A1 (en) 2018-12-20
HRP20191895T4 (hr) 2023-05-12
ME03732B (me) 2021-01-20
PT2738259T (pt) 2020-02-18
HRP20192311T1 (hr) 2020-03-20
MX343009B (es) 2016-10-21
HRP20191895T1 (hr) 2020-01-10
RU2722373C2 (ru) 2020-05-29
AU2022206806A1 (en) 2022-08-18
PT4067496T (pt) 2023-06-07
US20150210776A1 (en) 2015-07-30
CY1122459T1 (el) 2021-01-27
HUE062552T2 (hu) 2023-11-28
RU2582261C2 (ru) 2016-04-20
IL273986A (en) 2020-05-31
IL261243B (en) 2019-08-29
NZ776770A (en) 2023-03-31
US20180346599A1 (en) 2018-12-06
ME02106B (me) 2015-10-20
SI4067496T1 (sl) 2023-07-31
SG192933A1 (en) 2013-09-30
PL4067496T3 (pl) 2023-07-31
SI2578688T1 (sl) 2019-11-29
EP2550363B1 (en) 2014-12-10
LT4067496T (lt) 2023-06-12
ES2758974T5 (es) 2023-06-08
US12207628B2 (en) 2025-01-28
US20210105984A1 (en) 2021-04-15
CN103429746A (zh) 2013-12-04
US20210105985A1 (en) 2021-04-15
RS59929B1 (sr) 2020-03-31

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