JP2015525071A5 - - Google Patents
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- Publication number
- JP2015525071A5 JP2015525071A5 JP2015516160A JP2015516160A JP2015525071A5 JP 2015525071 A5 JP2015525071 A5 JP 2015525071A5 JP 2015516160 A JP2015516160 A JP 2015516160A JP 2015516160 A JP2015516160 A JP 2015516160A JP 2015525071 A5 JP2015525071 A5 JP 2015525071A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- human immunoglobulin
- chain variable
- heavy chain
- genetically engineered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 76
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 56
- 238000000034 method Methods 0.000 claims description 47
- 239000000427 antigen Substances 0.000 claims description 44
- 102000036639 antigens Human genes 0.000 claims description 44
- 108091007433 antigens Proteins 0.000 claims description 44
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 39
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 39
- 150000007523 nucleic acids Chemical group 0.000 claims description 24
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 23
- 210000004602 germ cell Anatomy 0.000 claims description 22
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims description 20
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims description 20
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims description 20
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims description 20
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims description 20
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 13
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 13
- 210000004027 cell Anatomy 0.000 claims description 13
- 102000025171 antigen binding proteins Human genes 0.000 claims description 12
- 108091000831 antigen binding proteins Proteins 0.000 claims description 12
- 241001529936 Murinae Species 0.000 claims description 5
- 241000699670 Mus sp. Species 0.000 claims description 4
- 230000003053 immunization Effects 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
- 238000012986 modification Methods 0.000 claims description 4
- 102000006395 Globulins Human genes 0.000 claims description 3
- 108010044091 Globulins Proteins 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 102100022964 Immunoglobulin kappa variable 3-20 Human genes 0.000 claims 15
- 210000003719 b-lymphocyte Anatomy 0.000 claims 10
- 101150097493 D gene Proteins 0.000 claims 2
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 2
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 2
- 238000002649 immunization Methods 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/488,628 US20130045492A1 (en) | 2010-02-08 | 2012-06-05 | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US13/488,628 | 2012-06-05 | ||
| PCT/US2013/044257 WO2013184761A1 (en) | 2012-06-05 | 2013-06-05 | Methods for making fully human bispecific antibodies using a common light chain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015525071A JP2015525071A (ja) | 2015-09-03 |
| JP2015525071A5 true JP2015525071A5 (https=) | 2016-07-21 |
Family
ID=48652344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516160A Pending JP2015525071A (ja) | 2012-06-05 | 2013-06-05 | 共通の軽鎖を用いて完全ヒト型二重特異性抗体を作製するための方法 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2854523A1 (https=) |
| JP (1) | JP2015525071A (https=) |
| KR (1) | KR20150023535A (https=) |
| CN (1) | CN104582476B (https=) |
| AU (1) | AU2013271737A1 (https=) |
| CA (1) | CA2874846A1 (https=) |
| HK (1) | HK1208994A1 (https=) |
| IL (1) | IL235781A0 (https=) |
| MX (1) | MX2014014891A (https=) |
| RU (1) | RU2014153674A (https=) |
| SG (2) | SG10201609535TA (https=) |
| WO (1) | WO2013184761A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| SMT202600080T1 (it) | 2010-02-08 | 2026-03-09 | Regeneron Pharma | Topo con catena leggera comune |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| EP2825036B1 (en) | 2012-03-16 | 2018-05-02 | Regeneron Pharmaceuticals, Inc. | Histidine engineered light chain antibodies and genetically modified rodents for generating the same |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| WO2013138681A1 (en) | 2012-03-16 | 2013-09-19 | Regeneron Pharmaceuticals, Inc. | Mice that produce antigen-binding proteins with ph-dependent binding characteristics |
| EP3539374A1 (en) | 2012-03-16 | 2019-09-18 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing ph-sensitive immunoglobulin sequences |
| US9248181B2 (en) | 2012-04-20 | 2016-02-02 | Merus B.V. | Methods and means for the production of Ig-like molecules |
| TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
| HK1218550A1 (zh) * | 2013-03-13 | 2017-02-24 | Regeneron Pharmaceuticals, Inc. | 常見輕鏈小鼠 |
| TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| KR102614189B1 (ko) | 2014-11-17 | 2023-12-18 | 리제너론 파아마슈티컬스, 인크. | Cd3xcd20 이특이적 항체를 이용한 종양의 치료 방법 |
| DK3221357T3 (da) * | 2014-11-20 | 2020-08-10 | Hoffmann La Roche | Fælles letkæder og fremgangsmåder til anvendelse |
| EP3023437A1 (en) * | 2014-11-20 | 2016-05-25 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| WO2016161010A2 (en) | 2015-03-30 | 2016-10-06 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
| EP3885368A1 (en) | 2015-05-12 | 2021-09-29 | Regeneron Pharmaceuticals, Inc. | Multimeric protein purity determination |
| AU2016325630B2 (en) * | 2015-09-23 | 2022-11-17 | Regeneron Pharmaceuticals, Inc. | Optimized anti-CD3 bispecific antibodies and uses thereof |
| TW202417497A (zh) | 2015-10-12 | 2024-05-01 | 美商再生元醫藥公司 | 活化瘦素受體的抗原結合蛋白 |
| KR20230006929A (ko) | 2016-01-13 | 2023-01-11 | 리제너론 파마슈티칼스 인코포레이티드 | 조작된 중쇄 다양성 영역을 갖는 설치류 |
| PT3773713T (pt) | 2018-04-06 | 2025-07-29 | Regeneron Pharma | Anticorpo agonista do recetor de leptina para usar no aumento da massa óssea num sujeito que sofre de disfunção metabólica ou de hipoleptinemia |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| CA3110513A1 (en) | 2018-08-31 | 2020-03-05 | Regeneron Pharmaceuticals, Inc. | Dosing strategy that mitigates cytokine release syndrome for cd3/c20 bispecific antibodies |
| US12583932B2 (en) * | 2018-11-16 | 2026-03-24 | Virtuoso Binco, Inc. | CD38 and ICAM1 antibodies and uses thereof |
| BR112021016173A2 (pt) | 2019-02-22 | 2021-11-03 | Regeneron Pharma | Roedor geneticamente modificado, métodos de produção de um roedor geneticamente modificado e de produção de um anticorpo anti-nav1.7, célula ou tecido isolado de roedor, linhagem celular imortalizada, embrião de roedor, construto de ácido nucleico de direcionamento, e, hibridoma |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| US20220090060A1 (en) | 2020-09-11 | 2022-03-24 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| CN116848254B (zh) | 2020-12-16 | 2026-03-17 | 瑞泽恩制药公司 | 表达人源化Fcα受体的小鼠 |
| IL303865A (en) | 2020-12-23 | 2023-08-01 | Regeneron Pharma | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce them |
| CA3165366A1 (en) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| CN118496357A (zh) * | 2023-02-15 | 2024-08-16 | 康源博创生物科技(北京)有限公司 | 一种多肽以及包含其作为轻链的抗体 |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| WO2026035843A2 (en) | 2024-08-06 | 2026-02-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68929167T2 (de) * | 1988-09-06 | 2000-11-16 | Xoma Corp., Berkeley | Genexpressions-Elemente und Herstellung von chimären Maus-Mensch-Antikörpern |
| US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| JPH08509612A (ja) * | 1993-04-26 | 1996-10-15 | ジェンファーム インターナショナル インコーポレイテッド | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| MXPA05000511A (es) * | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
| PT1652920E (pt) * | 2001-10-01 | 2010-11-08 | Deutsches Krebsforsch | Processo para a produção de bibliotecas de proteínas e para a selecção de proteínas a partir da mesma |
| WO2003061363A2 (en) * | 2002-01-17 | 2003-07-31 | Albert Einstein College Of Medicine Of Yeshiva University | Mutations caused by activation-induced cytidine deaminase |
| ES2524767T3 (es) * | 2002-06-14 | 2014-12-12 | Immunomedics, Inc. | Anticuerpo monoclonal humanizado HPAM4 |
| CN101962408A (zh) * | 2002-07-12 | 2011-02-02 | 杰斐逊·富特 | 超人源化抗体 |
| EP2147594B1 (en) * | 2008-06-27 | 2013-11-13 | Merus B.V. | Antibody producing non-human mammals |
| SMT202600080T1 (it) * | 2010-02-08 | 2026-03-09 | Regeneron Pharma | Topo con catena leggera comune |
| HUE047278T2 (hu) * | 2011-08-05 | 2020-04-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
-
2013
- 2013-06-05 MX MX2014014891A patent/MX2014014891A/es unknown
- 2013-06-05 AU AU2013271737A patent/AU2013271737A1/en not_active Abandoned
- 2013-06-05 KR KR20147036869A patent/KR20150023535A/ko not_active Withdrawn
- 2013-06-05 SG SG10201609535TA patent/SG10201609535TA/en unknown
- 2013-06-05 RU RU2014153674A patent/RU2014153674A/ru not_active Application Discontinuation
- 2013-06-05 JP JP2015516160A patent/JP2015525071A/ja active Pending
- 2013-06-05 HK HK15109745.2A patent/HK1208994A1/xx unknown
- 2013-06-05 EP EP13729875.8A patent/EP2854523A1/en not_active Ceased
- 2013-06-05 WO PCT/US2013/044257 patent/WO2013184761A1/en not_active Ceased
- 2013-06-05 CA CA2874846A patent/CA2874846A1/en not_active Abandoned
- 2013-06-05 CN CN201380030014.1A patent/CN104582476B/zh active Active
- 2013-06-05 SG SG11201407644UA patent/SG11201407644UA/en unknown
-
2014
- 2014-11-18 IL IL235781A patent/IL235781A0/en unknown
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