JP2015510767A5 - - Google Patents
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- JP2015510767A5 JP2015510767A5 JP2015500639A JP2015500639A JP2015510767A5 JP 2015510767 A5 JP2015510767 A5 JP 2015510767A5 JP 2015500639 A JP2015500639 A JP 2015500639A JP 2015500639 A JP2015500639 A JP 2015500639A JP 2015510767 A5 JP2015510767 A5 JP 2015510767A5
- Authority
- JP
- Japan
- Prior art keywords
- light chain
- antibody
- human
- item
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261611950P | 2012-03-16 | 2012-03-16 | |
| US61/611,950 | 2012-03-16 | ||
| US201261736930P | 2012-12-13 | 2012-12-13 | |
| US61/736,930 | 2012-12-13 | ||
| PCT/US2013/031823 WO2013138680A1 (en) | 2012-03-16 | 2013-03-15 | Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017052358A Division JP6574802B2 (ja) | 2012-03-16 | 2017-03-17 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015510767A JP2015510767A (ja) | 2015-04-13 |
| JP2015510767A5 true JP2015510767A5 (https=) | 2016-05-12 |
| JP6185978B2 JP6185978B2 (ja) | 2017-08-23 |
Family
ID=48045078
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500639A Active JP6185978B2 (ja) | 2012-03-16 | 2013-03-15 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
| JP2017052358A Active JP6574802B2 (ja) | 2012-03-16 | 2017-03-17 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
| JP2019029627A Active JP7304169B2 (ja) | 2012-03-16 | 2019-02-21 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
| JP2020066673A Active JP7199398B2 (ja) | 2012-03-16 | 2020-04-02 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
| JP2021183079A Withdrawn JP2022017547A (ja) | 2012-03-16 | 2021-11-10 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017052358A Active JP6574802B2 (ja) | 2012-03-16 | 2017-03-17 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
| JP2019029627A Active JP7304169B2 (ja) | 2012-03-16 | 2019-02-21 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
| JP2020066673A Active JP7199398B2 (ja) | 2012-03-16 | 2020-04-02 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
| JP2021183079A Withdrawn JP2022017547A (ja) | 2012-03-16 | 2021-11-10 | ヒスチジン操作された軽鎖抗体およびこれを作製するための遺伝子改変された非ヒト動物 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US9334334B2 (https=) |
| EP (4) | EP2825036B1 (https=) |
| JP (5) | JP6185978B2 (https=) |
| KR (1) | KR102228296B1 (https=) |
| CN (3) | CN104302169B (https=) |
| AU (3) | AU2013204579B2 (https=) |
| BR (1) | BR112014022850A2 (https=) |
| CA (1) | CA2865643A1 (https=) |
| CY (2) | CY1120599T1 (https=) |
| DK (2) | DK2825036T3 (https=) |
| ES (3) | ES2849349T3 (https=) |
| HR (2) | HRP20181228T1 (https=) |
| HU (3) | HUE037659T2 (https=) |
| IL (5) | IL234355B (https=) |
| LT (3) | LT3348140T (https=) |
| MX (2) | MX381210B (https=) |
| MY (1) | MY172730A (https=) |
| NZ (1) | NZ629639A (https=) |
| PL (2) | PL2825036T3 (https=) |
| PT (3) | PT2883449T (https=) |
| RS (2) | RS57118B1 (https=) |
| RU (2) | RU2644684C2 (https=) |
| SG (2) | SG10201607689PA (https=) |
| SI (3) | SI3348140T1 (https=) |
| SM (2) | SMT201800229T1 (https=) |
| WO (1) | WO2013138680A1 (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| ES2595638T3 (es) | 2007-09-26 | 2017-01-02 | Chugai Seiyaku Kabushiki Kaisha | Método para modificar el punto isoeléctrico de un anticuerpo mediante la sustitución de aminoácidos en una CDR |
| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| EP2647706B1 (en) | 2010-11-30 | 2023-05-17 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
| MX352889B (es) | 2011-02-25 | 2017-12-13 | Chugai Pharmaceutical Co Ltd | Anticuerpo de fc especifico para fcyriib. |
| TWI687439B (zh) | 2011-06-30 | 2020-03-11 | 中外製藥股份有限公司 | 異源二聚化多胜肽 |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| SG11201401181YA (en) | 2011-10-17 | 2014-04-28 | Regeneron Pharma | Restricted immunoglobulin heavy chain mice |
| KR20230143201A (ko) | 2011-11-30 | 2023-10-11 | 추가이 세이야쿠 가부시키가이샤 | 면역 복합체를 형성하는 세포내로의 운반체（캐리어）를 포함하는 의약 |
| EP3539374A1 (en) | 2012-03-16 | 2019-09-18 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing ph-sensitive immunoglobulin sequences |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| ME03551B (me) | 2012-06-12 | 2020-07-20 | Regeneron Pharma | Humanizovane nehumane živoтinje sa ograničenim lokusima imunoglobulinskog тeškog lanca |
| WO2014030750A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
| SG10201709559PA (en) | 2012-08-24 | 2017-12-28 | Chugai Pharmaceutical Co Ltd | Fcγriib-specific fc region variant |
| ES2876009T3 (es) | 2012-12-27 | 2021-11-11 | Chugai Pharmaceutical Co Ltd | Polipéptido heterodimerizado |
| MY178882A (en) | 2013-02-20 | 2020-10-21 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
| CN105246914B (zh) | 2013-04-02 | 2021-08-27 | 中外制药株式会社 | Fc区变体 |
| WO2014177459A2 (en) | 2013-04-29 | 2014-11-06 | F. Hoffmann-La Roche Ag | Fc-receptor binding modified asymmetric antibodies and methods of use |
| UA118029C2 (uk) | 2013-04-29 | 2018-11-12 | Ф. Хоффманн-Ля Рош Аг | Модифіковане антитіло, що зв'язується з людським fcrn, й способи його застосування |
| MX380658B (es) | 2014-01-15 | 2025-03-11 | Hoffmann La Roche | Variantes de region fc con union mejorada de la proteina a. |
| TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| CA2953714C (en) | 2014-06-30 | 2021-05-18 | Ralf Guenther | Anti-tnfa antibodies with ph-dependent antigen binding |
| KR101860280B1 (ko) | 2014-12-19 | 2018-05-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| BR112017011235A2 (pt) | 2014-12-19 | 2018-02-06 | Chugai Pharmaceutical Co Ltd | anticorpos anti-c5 e métodos de uso |
| CN113956354A (zh) * | 2015-01-22 | 2022-01-21 | 中外制药株式会社 | 两种以上抗-c5抗体的组合与使用方法 |
| KR102605798B1 (ko) | 2015-02-05 | 2023-11-23 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용 |
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| US10294306B2 (en) | 2015-05-28 | 2019-05-21 | Bio-Rad Laboratories, Inc. | Affinity ligands and methods relating thereto |
| HUE065073T2 (hu) * | 2015-12-18 | 2024-04-28 | Chugai Pharmaceutical Co Ltd | Anti-C5 antitestek és alkalmazási eljárások |
| AR107078A1 (es) * | 2015-12-18 | 2018-03-21 | Chugai Pharmaceutical Co Ltd | Anticuerpo antimiostatina, polipéptidos que contienen regiones fc variantes así como métodos de uso |
| LT3394103T (lt) | 2015-12-22 | 2023-09-11 | Regeneron Pharmaceuticals, Inc. | Antikūnų prieš pd-1 ir bispecifinių antikūnų prieš cd20/cd3 derinys, skirtas vėžiui gydyti |
| WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| CN113831407B (zh) | 2016-05-20 | 2024-06-11 | 瑞泽恩制药公司 | 用于使用多个引导rna来破坏免疫耐受性的方法 |
| KR102483193B1 (ko) | 2016-06-03 | 2023-01-04 | 리제너론 파마슈티칼스 인코포레이티드 | 외인성 말단 데옥시뉴클레오타이드 전달효소를 발현하는 비인간 동물 |
| EP3494991A4 (en) | 2016-08-05 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | COMPOSITION FOR THE PROPHYLAXIS OR TREATMENT OF IL-8 RELATED DISEASES |
| GB201707484D0 (en) * | 2017-05-10 | 2017-06-21 | Argenx Bvba | Method of preparing ph-dependent antibodies |
| EP4640703A3 (en) | 2017-11-14 | 2026-04-08 | Chugai Seiyaku Kabushiki Kaisha | Anti-c1s antibodies and methods of use |
| KR20200131838A (ko) * | 2018-03-14 | 2020-11-24 | 에프. 호프만-라 로슈 아게 | 항체의 친화성 성숙화를 위한 방법 |
| EP3772927B1 (en) * | 2018-03-24 | 2025-01-15 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice or rats for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| IL314733A (en) | 2018-03-26 | 2024-10-01 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| KR102259473B1 (ko) | 2018-08-10 | 2021-06-02 | 추가이 세이야쿠 가부시키가이샤 | 항cd137 항원 결합 분자 및 그의 사용 |
| JP6935383B2 (ja) * | 2018-09-27 | 2021-09-15 | 公益財団法人実験動物中央研究所 | 免疫不全マウス |
| SI3880186T1 (sl) | 2018-11-14 | 2024-07-31 | Regeneron Pharmaceuticals, Inc., | Intralezijska uporaba zaviralcev PD-1 za zdravljenje kožnega raka |
| EP3950263B1 (en) | 2019-04-04 | 2026-02-11 | Nissei Asb Machine Co., Ltd. | Method for producing resin container, injection core mold, mold for injection molding, and device for producing resin container |
| EP4696320A2 (en) | 2019-05-15 | 2026-02-18 | Chugai Seiyaku Kabushiki Kaisha | Anti-c1s antibody |
| MX2021014893A (es) | 2019-06-05 | 2022-03-11 | Regeneron Pharma | Animales no humanos que tienen un repertorio de cadena ligera lambda limitado expresado a partir del locus kappa y usos de estos. |
| IL292353A (en) * | 2019-10-28 | 2022-06-01 | Regeneron Pharma | Anti-haemagglutinin antibodies and methods of using them |
| KR20230042518A (ko) * | 2020-08-04 | 2023-03-28 | 씨젠 인크. | 항-cd228 항체 및 항체-약물 컨쥬게이트 |
| CN116194142A (zh) | 2020-09-03 | 2023-05-30 | 瑞泽恩制药公司 | 通过施用pd-1抑制剂治疗癌症疼痛的方法 |
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| EP4477744A4 (en) | 2022-02-07 | 2025-06-11 | Osaka University | METHOD FOR INDUCING DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO RETINAL PIGMENT EPITHELIAL CELLS |
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