JP2015509380A5 - - Google Patents
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- Publication number
- JP2015509380A5 JP2015509380A5 JP2014561037A JP2014561037A JP2015509380A5 JP 2015509380 A5 JP2015509380 A5 JP 2015509380A5 JP 2014561037 A JP2014561037 A JP 2014561037A JP 2014561037 A JP2014561037 A JP 2014561037A JP 2015509380 A5 JP2015509380 A5 JP 2015509380A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- heavy chain
- mouse
- immunoglobulin heavy
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 41
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 33
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 33
- 239000000427 antigen Substances 0.000 claims description 26
- 102000036639 antigens Human genes 0.000 claims description 26
- 108091007433 antigens Proteins 0.000 claims description 26
- 108060003951 Immunoglobulin Proteins 0.000 claims description 17
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 17
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 17
- 102000018358 immunoglobulin Human genes 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 15
- 241000699666 Mus <mouse, genus> Species 0.000 claims 26
- 210000003719 b-lymphocyte Anatomy 0.000 claims 15
- 102000025171 antigen binding proteins Human genes 0.000 claims 14
- 108091000831 antigen binding proteins Proteins 0.000 claims 14
- 210000004602 germ cell Anatomy 0.000 claims 7
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 4
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 241000699670 Mus sp. Species 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000000392 somatic effect Effects 0.000 claims 1
- 101150039504 6 gene Proteins 0.000 description 1
- 101100370002 Mus musculus Tnfsf14 gene Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/412,936 | 2012-03-06 | ||
| US13/412,936 US20120192300A1 (en) | 2010-02-08 | 2012-03-06 | Common Light Chain Mouse |
| PCT/US2013/029125 WO2013134263A1 (en) | 2012-03-06 | 2013-03-05 | Common light chain mouse |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018088350A Division JP2018138047A (ja) | 2010-02-08 | 2018-05-01 | 共通の軽鎖のマウス |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015509380A JP2015509380A (ja) | 2015-03-30 |
| JP2015509380A5 true JP2015509380A5 (https=) | 2016-04-28 |
Family
ID=47998513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014561037A Withdrawn JP2015509380A (ja) | 2012-03-06 | 2013-03-05 | 共通の軽鎖のマウス |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP3165086A1 (https=) |
| JP (1) | JP2015509380A (https=) |
| KR (1) | KR20140136462A (https=) |
| CN (2) | CN104244709B (https=) |
| AU (2) | AU2013204140B2 (https=) |
| CA (1) | CA2865029A1 (https=) |
| HK (1) | HK1205873A1 (https=) |
| IL (1) | IL234207A0 (https=) |
| IN (1) | IN2014DN08163A (https=) |
| MX (1) | MX353278B (https=) |
| NZ (1) | NZ630637A (https=) |
| RU (1) | RU2683514C2 (https=) |
| SG (1) | SG11201405088QA (https=) |
| WO (1) | WO2013134263A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| BR112012000536A2 (pt) | 2009-07-08 | 2020-08-11 | Kymab Limited | métodos para produção de anticorpo ou cadeia leve ou pesada de anticorpo específico para um antígeno desejado, para produção de anticorpo ou cadeia de anticorpo e seu uso, composição farmacêutica e derivado de anticorpo quimérico |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| SI2501817T2 (sl) | 2010-02-08 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Miš z navadno lahko verigo |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| BR112014006394A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| SG10201700360VA (en) | 2012-03-16 | 2017-03-30 | Regeneron Pharma | Non-human animals expressing ph-sensitive immunoglobulin sequences |
| KR102228296B1 (ko) | 2012-03-16 | 2021-03-17 | 리제너론 파마슈티칼스 인코포레이티드 | 히스티딘 공학처리된 경쇄 항체 및 그것을 생성하기 위한 유전자 변형된 비-사람 동물 |
| MX2014011047A (es) | 2012-03-16 | 2015-04-08 | Regeneron Pharma | Ratones que producen proteinas de union a un antigeno con caracteristicas de union dependientes del ph. |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| SI2838917T1 (sl) | 2012-04-20 | 2019-11-29 | Merus Nv | Postopki in sredstva za produkcijo heterodimernih IG-podobnih molekul |
| CN105189545A (zh) * | 2013-03-13 | 2015-12-23 | 瑞泽恩制药公司 | 常见轻链小鼠 |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| FR3011249A1 (https=) * | 2013-10-01 | 2015-04-03 | Kymab Ltd | |
| DE112014004537T5 (de) | 2013-10-01 | 2016-07-21 | Kymab Limited | Tiermodelle und therapeutische Moleküle |
| KR102276752B1 (ko) | 2014-03-21 | 2021-07-13 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 도메인 결합 단백질을 생산하는 비-인간 동물 |
| EP3271403A1 (en) | 2015-03-19 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| RU2018109739A (ru) * | 2015-08-27 | 2019-09-20 | Кристал Байосайнс Инк. | Трансгенное животное для получения антител, имеющих общую легкую цепь |
| AU2017206785C1 (en) | 2016-01-13 | 2023-09-07 | Regeneron Pharmaceuticals, Inc. | Rodents having an engineered heavy chain diversity region |
| KR102480493B1 (ko) | 2018-06-08 | 2022-12-21 | 크리스탈 바이오사이언스 주식회사 | 동일한 경쇄 i을 갖는 다양한 항체를 생산하기 위한 트랜스제닉 동물 |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| EP3927832A4 (en) | 2019-02-18 | 2022-11-30 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | GENETICALLY MODIFIED NON-HUMAN ANIMALS WITH HUMANIZED IMMUNOGLOBULIN LOCUS |
| JP2022520819A (ja) | 2019-02-22 | 2022-04-01 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 遺伝子改変ナトリウムチャネルを有する齧歯類およびその使用方法 |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| KR20230018439A (ko) | 2020-06-02 | 2023-02-07 | 바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 | 공동 경쇄 면역글로불린 좌위를 갖는 유전자 변형 비인간 동물 |
| CA3187680A1 (en) | 2020-09-11 | 2022-03-17 | Yashu Liu | Identification and production of antigen-specific antibodies |
| WO2022132943A1 (en) | 2020-12-16 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| CA3165366A1 (en) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| TW202242114A (zh) | 2020-12-23 | 2022-11-01 | 美商再生元醫藥公司 | 用於獲得結合至跨膜蛋白之抗體以及抗體生成細胞的方法 |
| GB202217978D0 (en) | 2022-11-30 | 2023-01-11 | Petmedix Ltd | Rodents expressing a common light chain |
| TW202430641A (zh) | 2023-01-18 | 2024-08-01 | 美商基利科學股份有限公司 | 人類免疫球蛋白二元輕鏈轉殖基因構築體及其用途 |
| WO2026019824A1 (en) | 2024-07-16 | 2026-01-22 | Gilead Sciences, Inc. | Human immunoglobulin common light chain transgene constructs and uses thereof |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| WO2026035843A2 (en) | 2024-08-06 | 2026-02-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7084260B1 (en) * | 1996-10-10 | 2006-08-01 | Genpharm International, Inc. | High affinity human antibodies and human antibodies against human antigens |
| US20020062010A1 (en) * | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| NZ537277A (en) * | 2002-07-18 | 2008-04-30 | Crucell Holland Bv | Recombinant production of mixtures of antibodies |
| US20100069614A1 (en) * | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| AU2005295269B2 (en) | 2004-10-19 | 2010-05-13 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
| ES2398076T3 (es) | 2006-06-02 | 2013-03-13 | Regeneron Pharmaceuticals, Inc. | Anticuerpos de alta afinidad contra el receptor de IL-6 humano |
| PL3456190T3 (pl) * | 2008-06-27 | 2022-06-06 | Merus N.V. | Wytwarzające przeciwciała transgeniczne zwierzę z gatunku myszy |
| JP5816170B2 (ja) | 2009-06-26 | 2015-11-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 天然の免疫グロブリン形式を有する容易に単離される二重特異性抗体 |
| BR112012000536A2 (pt) * | 2009-07-08 | 2020-08-11 | Kymab Limited | métodos para produção de anticorpo ou cadeia leve ou pesada de anticorpo específico para um antígeno desejado, para produção de anticorpo ou cadeia de anticorpo e seu uso, composição farmacêutica e derivado de anticorpo quimérico |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| SI2501817T2 (sl) * | 2010-02-08 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Miš z navadno lahko verigo |
-
2013
- 2013-03-05 IN IN8163DEN2014 patent/IN2014DN08163A/en unknown
- 2013-03-05 MX MX2014010794A patent/MX353278B/es active IP Right Grant
- 2013-03-05 SG SG11201405088QA patent/SG11201405088QA/en unknown
- 2013-03-05 JP JP2014561037A patent/JP2015509380A/ja not_active Withdrawn
- 2013-03-05 CA CA2865029A patent/CA2865029A1/en not_active Abandoned
- 2013-03-05 AU AU2013204140A patent/AU2013204140B2/en active Active
- 2013-03-05 CN CN201380012671.3A patent/CN104244709B/zh active Active
- 2013-03-05 RU RU2014140239A patent/RU2683514C2/ru active
- 2013-03-05 CN CN201611201918.8A patent/CN107090471A/zh active Pending
- 2013-03-05 NZ NZ630637A patent/NZ630637A/en unknown
- 2013-03-05 KR KR20147026624A patent/KR20140136462A/ko not_active Ceased
- 2013-03-05 EP EP16203839.2A patent/EP3165086A1/en not_active Withdrawn
- 2013-03-05 HK HK15106625.3A patent/HK1205873A1/xx unknown
- 2013-03-05 WO PCT/US2013/029125 patent/WO2013134263A1/en not_active Ceased
- 2013-03-05 EP EP13712618.1A patent/EP2822379A1/en not_active Withdrawn
-
2014
- 2014-08-19 IL IL234207A patent/IL234207A0/en active IP Right Grant
-
2016
- 2016-04-20 AU AU2016202488A patent/AU2016202488C1/en active Active
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