JP2013532974A5 - - Google Patents
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- JP2013532974A5 JP2013532974A5 JP2013516714A JP2013516714A JP2013532974A5 JP 2013532974 A5 JP2013532974 A5 JP 2013532974A5 JP 2013516714 A JP2013516714 A JP 2013516714A JP 2013516714 A JP2013516714 A JP 2013516714A JP 2013532974 A5 JP2013532974 A5 JP 2013532974A5
- Authority
- JP
- Japan
- Prior art keywords
- mouse
- human
- light chain
- gene
- endogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35731710P | 2010-06-22 | 2010-06-22 | |
| US35731410P | 2010-06-22 | 2010-06-22 | |
| US61/357,314 | 2010-06-22 | ||
| US61/357,317 | 2010-06-22 | ||
| PCT/US2011/041366 WO2011163311A1 (en) | 2010-06-22 | 2011-06-22 | Mice expressing alight chain with human lambda variable and mouse constant regions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015205321A Division JP6243384B2 (ja) | 2010-06-22 | 2015-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532974A JP2013532974A (ja) | 2013-08-22 |
| JP2013532974A5 true JP2013532974A5 (https=) | 2014-07-17 |
| JP5988969B2 JP5988969B2 (ja) | 2016-09-07 |
Family
ID=44509861
Family Applications (17)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516716A Active JP6009441B2 (ja) | 2010-06-22 | 2011-06-22 | ハイブリッド軽鎖マウス |
| JP2013516714A Active JP5988969B2 (ja) | 2010-06-22 | 2011-06-22 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2015205439A Active JP6073441B2 (ja) | 2010-06-22 | 2015-10-19 | ハイブリッド軽鎖マウス |
| JP2015205321A Active JP6243384B2 (ja) | 2010-06-22 | 2015-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016204854A Withdrawn JP2017006152A (ja) | 2010-06-22 | 2016-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016208582A Active JP6341972B2 (ja) | 2010-06-22 | 2016-10-25 | ハイブリッド軽鎖マウス |
| JP2017222512A Active JP6545773B2 (ja) | 2010-06-22 | 2017-11-20 | ハイブリッド軽鎖マウス |
| JP2018188847A Pending JP2018201528A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018188846A Pending JP2018201527A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018228851A Active JP6963542B2 (ja) | 2010-06-22 | 2018-12-06 | ハイブリッド軽鎖マウス |
| JP2020015538A Withdrawn JP2020062061A (ja) | 2010-06-22 | 2020-01-31 | ハイブリッド軽鎖マウス |
| JP2020098480A Active JP7236409B2 (ja) | 2010-06-22 | 2020-06-05 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2021009451A Withdrawn JP2021061863A (ja) | 2010-06-22 | 2021-01-25 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2022034415A Withdrawn JP2022066449A (ja) | 2010-06-22 | 2022-03-07 | ハイブリッド軽鎖マウス |
| JP2023127047A Withdrawn JP2023133554A (ja) | 2010-06-22 | 2023-08-03 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2024214653A Pending JP2025027148A (ja) | 2010-06-22 | 2024-12-09 | ハイブリッド軽鎖マウス |
| JP2026022125A Pending JP2026066390A (ja) | 2010-06-22 | 2026-02-13 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516716A Active JP6009441B2 (ja) | 2010-06-22 | 2011-06-22 | ハイブリッド軽鎖マウス |
Family Applications After (15)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015205439A Active JP6073441B2 (ja) | 2010-06-22 | 2015-10-19 | ハイブリッド軽鎖マウス |
| JP2015205321A Active JP6243384B2 (ja) | 2010-06-22 | 2015-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016204854A Withdrawn JP2017006152A (ja) | 2010-06-22 | 2016-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016208582A Active JP6341972B2 (ja) | 2010-06-22 | 2016-10-25 | ハイブリッド軽鎖マウス |
| JP2017222512A Active JP6545773B2 (ja) | 2010-06-22 | 2017-11-20 | ハイブリッド軽鎖マウス |
| JP2018188847A Pending JP2018201528A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018188846A Pending JP2018201527A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018228851A Active JP6963542B2 (ja) | 2010-06-22 | 2018-12-06 | ハイブリッド軽鎖マウス |
| JP2020015538A Withdrawn JP2020062061A (ja) | 2010-06-22 | 2020-01-31 | ハイブリッド軽鎖マウス |
| JP2020098480A Active JP7236409B2 (ja) | 2010-06-22 | 2020-06-05 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2021009451A Withdrawn JP2021061863A (ja) | 2010-06-22 | 2021-01-25 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2022034415A Withdrawn JP2022066449A (ja) | 2010-06-22 | 2022-03-07 | ハイブリッド軽鎖マウス |
| JP2023127047A Withdrawn JP2023133554A (ja) | 2010-06-22 | 2023-08-03 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2024214653A Pending JP2025027148A (ja) | 2010-06-22 | 2024-12-09 | ハイブリッド軽鎖マウス |
| JP2026022125A Pending JP2026066390A (ja) | 2010-06-22 | 2026-02-13 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
Country Status (30)
| Country | Link |
|---|---|
| US (22) | US9012717B2 (https=) |
| EP (7) | EP2905338B8 (https=) |
| JP (17) | JP6009441B2 (https=) |
| KR (16) | KR20220150430A (https=) |
| CN (4) | CN103068994B (https=) |
| AU (1) | AU2011271046B2 (https=) |
| BR (3) | BR112012033248A2 (https=) |
| CA (2) | CA2803864C (https=) |
| CY (5) | CY1117537T1 (https=) |
| DK (5) | DK2905338T3 (https=) |
| ES (5) | ES2575223T3 (https=) |
| HR (5) | HRP20160794T1 (https=) |
| HU (5) | HUE044001T2 (https=) |
| IL (12) | IL300712B2 (https=) |
| LT (4) | LT2905338T (https=) |
| ME (5) | ME02442B (https=) |
| MX (6) | MX336344B (https=) |
| MY (6) | MY157477A (https=) |
| NO (1) | NO2905338T3 (https=) |
| NZ (6) | NZ605751A (https=) |
| PL (5) | PL2568049T3 (https=) |
| PT (5) | PT2480675T (https=) |
| RS (5) | RS55037B1 (https=) |
| RU (3) | RU2590594C2 (https=) |
| SG (4) | SG10201504324UA (https=) |
| SI (5) | SI2480675T1 (https=) |
| SM (5) | SMT201900241T1 (https=) |
| TR (1) | TR201905992T4 (https=) |
| WO (2) | WO2011163311A1 (https=) |
| ZA (5) | ZA201300062B (https=) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| EP2346994B1 (en) | 2008-09-30 | 2022-02-16 | Ablexis, LLC | Knock-in mice for the production of chimeric antibodies |
| JP5827127B2 (ja) | 2008-12-18 | 2015-12-02 | エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム | ヒト化抗体を発現する非ヒトトランスジェニック動物及びその使用 |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| BR112012000536A2 (pt) | 2009-07-08 | 2020-08-11 | Kymab Limited | métodos para produção de anticorpo ou cadeia leve ou pesada de anticorpo específico para um antígeno desejado, para produção de anticorpo ou cadeia de anticorpo e seu uso, composição farmacêutica e derivado de anticorpo quimérico |
| SI2501817T2 (sl) | 2010-02-08 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Miš z navadno lahko verigo |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| KR102203727B1 (ko) | 2010-03-31 | 2021-01-18 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작 |
| US9012717B2 (en) | 2010-06-22 | 2015-04-21 | Regeneron Pharmaceuticals, Inc. | Human lambda light chain mice |
| JP6482757B2 (ja) | 2010-07-26 | 2019-03-13 | トリアンニ インコーポレイテッドＴｒｉａｎｎｉ，Ｉｎｃ． | トランスジェニック動物および使用方法 |
| US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| SG10201912639SA (en) * | 2010-08-02 | 2020-02-27 | Regeneron Pharma | Mice that make binding proteins comprising vl domains |
| RS59728B1 (sr) | 2011-08-05 | 2020-02-28 | Regeneron Pharma | Humanizovani miševi univerzalnog lakog lanca |
| BR112014006394A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos |
| WO2013041845A2 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Animals, repertoires & methods |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| RU2664181C2 (ru) | 2011-12-20 | 2018-08-15 | Регенерон Фармасьютикалз, Инк. | Мыши с гуманизированной легкой цепью |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| SG10201700360VA (en) | 2012-03-16 | 2017-03-30 | Regeneron Pharma | Non-human animals expressing ph-sensitive immunoglobulin sequences |
| MX2014011047A (es) | 2012-03-16 | 2015-04-08 | Regeneron Pharma | Ratones que producen proteinas de union a un antigeno con caracteristicas de union dependientes del ph. |
| KR102228296B1 (ko) | 2012-03-16 | 2021-03-17 | 리제너론 파마슈티칼스 인코포레이티드 | 히스티딘 공학처리된 경쇄 항체 및 그것을 생성하기 위한 유전자 변형된 비-사람 동물 |
| JP2015512635A (ja) | 2012-03-28 | 2015-04-30 | カイマブ・リミテッド | クラススイッチした完全ヒト抗体の発現のためのトランスジェニック非−ヒト脊椎動物 |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| EP2840892B1 (en) | 2013-02-20 | 2018-04-18 | Regeneron Pharmaceuticals, Inc. | Non-human animals with modified immunoglobulin heavy chain sequences |
| WO2014160202A1 (en) * | 2013-03-13 | 2014-10-02 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US9980470B2 (en) | 2013-03-14 | 2018-05-29 | Erasmus University Medical Center | Antibody production |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| MY191512A (en) * | 2013-09-18 | 2022-06-28 | Regeneron Pharma | Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same |
| DE112014004537T5 (de) | 2013-10-01 | 2016-07-21 | Kymab Limited | Tiermodelle und therapeutische Moleküle |
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| KR102276752B1 (ko) | 2014-03-21 | 2021-07-13 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 도메인 결합 단백질을 생산하는 비-인간 동물 |
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| SG11201702606TA (en) | 2014-10-03 | 2017-04-27 | Massachusetts Inst Technology | Antibodies that bind ebola glycoprotein and uses thereof |
| MY189836A (en) | 2014-11-21 | 2022-03-11 | Bristol Myers Squibb Co | Antibodies against cd73 and uses thereof |
| CN113563468A (zh) | 2014-12-19 | 2021-10-29 | 雷根尼桑斯公司 | 结合人c6的抗体及其用途 |
| CN107207594B (zh) | 2014-12-23 | 2019-05-07 | 百时美施贵宝公司 | 针对tigit的抗体 |
| AU2016214399B2 (en) | 2015-02-05 | 2020-01-16 | Basf Se | Solar power plant comprising a first heat transfer circuit and a second heat transfer circuit |
| EP3271403A1 (en) | 2015-03-19 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| TN2019000101A1 (en) | 2015-05-29 | 2020-07-15 | Bristol Myers Squibb Co | Antibodies against ox40 and uses thereof. |
| AU2016285920A1 (en) | 2015-06-29 | 2018-02-01 | Bristol-Myers Squibb Company | Antibodies to CD40 with enhanced agonist activity |
| CN105274116B (zh) * | 2015-10-21 | 2020-09-29 | 重庆金迈博生物科技有限公司 | 一种制备人源化抗体的核酸分子及其应用 |
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| AU2017213633B2 (en) | 2016-02-04 | 2023-08-03 | Trianni, Inc. | Enhanced production of immunoglobulins |
| ES2985566T3 (es) | 2016-03-04 | 2024-11-06 | Univ Rockefeller | Anticuerpos contra CD40 con actividad agonista mejorada |
| KR20230038311A (ko) | 2016-03-04 | 2023-03-17 | 브리스톨-마이어스 스큅 컴퍼니 | 항-cd73 항체와의 조합 요법 |
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| HUE061619T2 (hu) | 2016-06-03 | 2023-07-28 | Regeneron Pharma | Exogén terminális dezoxinukleotid-transzferázt expresszáló rágcsálók |
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| CN110506057B (zh) | 2017-02-17 | 2023-09-29 | 百时美施贵宝公司 | Alpha突触核蛋白抗体及其应用 |
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| DK4140297T3 (da) * | 2017-12-05 | 2025-06-23 | Regeneron Pharma | Mus med en konstrueret immunglobulin-lambda-letkæde og anvendelser deraf |
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| PE20210665A1 (es) | 2018-03-23 | 2021-03-31 | Bristol Myers Squibb Co | Anticuerpos contra mica y/o micb y sus usos |
| WO2019190922A1 (en) | 2018-03-24 | 2019-10-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| KR20250121150A (ko) | 2018-03-26 | 2025-08-11 | 리제너론 파마슈티칼스 인코포레이티드 | 치료제를 시험하기 위한 인간화된 설치류 |
| KR102480493B1 (ko) | 2018-06-08 | 2022-12-21 | 크리스탈 바이오사이언스 주식회사 | 동일한 경쇄 i을 갖는 다양한 항체를 생산하기 위한 트랜스제닉 동물 |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| EP3872506A4 (en) | 2018-10-26 | 2023-01-11 | Vehicle Energy Japan Inc. | Battery control device |
| US11274150B2 (en) | 2018-11-16 | 2022-03-15 | Bristol-Myers Squibb Company | Anti-human natural killer cell inhibitory receptor group 2A protein (NKG2A) antibodies |
| US11008395B2 (en) | 2019-01-22 | 2021-05-18 | Bristol Myers-Squibb Company | Antibodies against IL-7R alpha subunit and uses thereof |
| JP2022520819A (ja) | 2019-02-22 | 2022-04-01 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 遺伝子改変ナトリウムチャネルを有する齧歯類およびその使用方法 |
| SG11202111258TA (en) * | 2019-06-05 | 2021-11-29 | Regeneron Pharma | Non-human animals having a limited lambda light chain repertoire expressed from the kappa locus and uses thereof |
| WO2021003152A1 (en) * | 2019-07-01 | 2021-01-07 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| JP7726881B2 (ja) | 2019-12-02 | 2025-08-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ペプチド－ｍｈｃ ｉｉタンパク質構築物およびそれらの使用 |
| WO2021231732A1 (en) | 2020-05-15 | 2021-11-18 | Bristol-Myers Squibb Company | Antibodies to garp |
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