JP2020501516A5 - - Google Patents

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Publication number
JP2020501516A5
JP2020501516A5 JP2019522647A JP2019522647A JP2020501516A5 JP 2020501516 A5 JP2020501516 A5 JP 2020501516A5 JP 2019522647 A JP2019522647 A JP 2019522647A JP 2019522647 A JP2019522647 A JP 2019522647A JP 2020501516 A5 JP2020501516 A5 JP 2020501516A5
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JP
Japan
Prior art keywords
human
mouse
gene segments
light chain
immunoglobulin
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JP2019522647A
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English (en)
Japanese (ja)
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JP6884860B2 (ja
JP2020501516A (ja
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Priority claimed from PCT/US2017/060006 external-priority patent/WO2018128691A1/en
Publication of JP2020501516A publication Critical patent/JP2020501516A/ja
Publication of JP2020501516A5 publication Critical patent/JP2020501516A5/ja
Application granted granted Critical
Publication of JP6884860B2 publication Critical patent/JP6884860B2/ja
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JP2019522647A 2016-11-04 2017-11-03 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 Active JP6884860B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662417845P 2016-11-04 2016-11-04
US62/417,845 2016-11-04
US201762567932P 2017-10-04 2017-10-04
US62/567,932 2017-10-04
PCT/US2017/060006 WO2018128691A1 (en) 2016-11-04 2017-11-03 Non-human animals having an engineered immunoglobulin lambda light chain locus

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021036180A Division JP2021090455A (ja) 2016-11-04 2021-03-08 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物

Publications (3)

Publication Number Publication Date
JP2020501516A JP2020501516A (ja) 2020-01-23
JP2020501516A5 true JP2020501516A5 (https=) 2020-12-10
JP6884860B2 JP6884860B2 (ja) 2021-06-09

Family

ID=62025924

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2019522647A Active JP6884860B2 (ja) 2016-11-04 2017-11-03 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2021036180A Withdrawn JP2021090455A (ja) 2016-11-04 2021-03-08 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2022109658A Active JP7386292B2 (ja) 2016-11-04 2022-07-07 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2023023312A Withdrawn JP2023053400A (ja) 2016-11-04 2023-02-17 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2025135726A Pending JP2025166207A (ja) 2016-11-04 2025-08-18 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2021036180A Withdrawn JP2021090455A (ja) 2016-11-04 2021-03-08 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2022109658A Active JP7386292B2 (ja) 2016-11-04 2022-07-07 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2023023312A Withdrawn JP2023053400A (ja) 2016-11-04 2023-02-17 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2025135726A Pending JP2025166207A (ja) 2016-11-04 2025-08-18 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物

Country Status (26)

Country Link
US (3) US10820582B2 (https=)
EP (4) EP4567119A3 (https=)
JP (5) JP6884860B2 (https=)
KR (4) KR20240055863A (https=)
CN (2) CN114369157A (https=)
AU (2) AU2017391167B2 (https=)
BR (1) BR112019008675A2 (https=)
CA (1) CA3038720A1 (https=)
CY (2) CY1123491T1 (https=)
DK (3) DK3766343T3 (https=)
ES (3) ES2915609T3 (https=)
FI (1) FI4082334T3 (https=)
HR (3) HRP20250695T1 (https=)
HU (3) HUE052087T2 (https=)
IL (2) IL266282B2 (https=)
LT (3) LT3766343T (https=)
MA (2) MA44091A (https=)
MX (2) MX385857B (https=)
PL (3) PL3407709T3 (https=)
PT (3) PT4082334T (https=)
RS (3) RS63390B1 (https=)
RU (2) RU2757665C2 (https=)
SG (2) SG10201913483XA (https=)
SI (3) SI4082334T1 (https=)
SM (3) SMT202200259T1 (https=)
WO (1) WO2018128691A1 (https=)

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US10813346B2 (en) 2015-12-03 2020-10-27 Trianni, Inc. Enhanced immunoglobulin diversity
SG10201913483XA (en) 2016-11-04 2020-03-30 Regeneron Pharma Non-human animals having an engineered immunoglobulin lambda light chain locus
EP3772927B1 (en) 2018-03-24 2025-01-15 Regeneron Pharmaceuticals, Inc. Genetically modified mice or rats for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof
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BR112021016173A2 (pt) 2019-02-22 2021-11-03 Regeneron Pharma Roedor geneticamente modificado, métodos de produção de um roedor geneticamente modificado e de produção de um anticorpo anti-nav1.7, célula ou tecido isolado de roedor, linhagem celular imortalizada, embrião de roedor, construto de ácido nucleico de direcionamento, e, hibridoma
DK3993623T3 (da) * 2019-07-01 2025-05-26 Zoetis Services Llc Transgene gnavere og fremgangsmåder til anvendelse deraf
JP2023529846A (ja) * 2020-06-02 2023-07-12 バイオサイトジェン ファーマシューティカルズ （ベイジン） カンパニー リミテッド 共通軽鎖免疫グロブリン遺伝子座を有する遺伝子改変非ヒト動物
US20220090060A1 (en) 2020-09-11 2022-03-24 Regeneron Pharmaceuticals, Inc. Identification and production of antigen-specific antibodies
CN116848254B (zh) 2020-12-16 2026-03-17 瑞泽恩制药公司 表达人源化Fcα受体的小鼠
CA3165366A1 (en) 2020-12-23 2022-06-30 Regeneron Pharmaceuticals, Inc. Nucleic acids encoding anchor modified antibodies and uses thereof
IL303865A (en) 2020-12-23 2023-08-01 Regeneron Pharma Methods for obtaining antibodies that bind transmembrane proteins and cells that produce them
KR20240110577A (ko) * 2021-11-10 2024-07-15 트리아니, 인코포레이티드 유전자이식 포유동물 및 이의 사용 방법
GB202217978D0 (en) * 2022-11-30 2023-01-11 Petmedix Ltd Rodents expressing a common light chain
WO2026030428A2 (en) 2024-08-01 2026-02-05 Regeneron Pharmaceuticals, Inc. Prostate-specific antigen peptides and uses thereof
WO2026035843A2 (en) 2024-08-06 2026-02-12 Regeneron Pharmaceuticals, Inc. Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof

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