JP2012525819A5 - - Google Patents
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- Publication number
- JP2012525819A5 JP2012525819A5 JP2012508822A JP2012508822A JP2012525819A5 JP 2012525819 A5 JP2012525819 A5 JP 2012525819A5 JP 2012508822 A JP2012508822 A JP 2012508822A JP 2012508822 A JP2012508822 A JP 2012508822A JP 2012525819 A5 JP2012525819 A5 JP 2012525819A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- seq
- amino acid
- positions
- wild
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000040430 polynucleotide Human genes 0.000 claims 17
- 239000002157 polynucleotide Substances 0.000 claims 17
- 108091033319 polynucleotide Proteins 0.000 claims 17
- 108060001084 Luciferase Proteins 0.000 claims 13
- 239000005089 Luciferase Substances 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 238000006467 substitution reaction Methods 0.000 claims 9
- 238000004020 luminiscence type Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 102220531101 Left-right determination factor 1_L92S_mutation Human genes 0.000 claims 1
- 102220492844 Olfactory receptor 8K5_F68S_mutation Human genes 0.000 claims 1
- 102220634786 Potassium voltage-gated channel subfamily A member 3_F77W_mutation Human genes 0.000 claims 1
- 241001284373 Spinus Species 0.000 claims 1
- 102220604980 Transcription factor Sp2_A33K_mutation Human genes 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 102220357107 c.224T>G Human genes 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 102200080930 rs137852221 Human genes 0.000 claims 1
- 102220055135 rs149428656 Human genes 0.000 claims 1
- 102220050200 rs150634297 Human genes 0.000 claims 1
- 102200082940 rs33936254 Human genes 0.000 claims 1
- 102200036809 rs387907341 Human genes 0.000 claims 1
- 102220000379 rs397514441 Human genes 0.000 claims 1
- 102220087238 rs541028076 Human genes 0.000 claims 1
- 102220025301 rs587778874 Human genes 0.000 claims 1
- 102220045199 rs587781908 Human genes 0.000 claims 1
- 102220058220 rs730881937 Human genes 0.000 claims 1
- 102220101693 rs771554497 Human genes 0.000 claims 1
- 102200137195 rs7897309 Human genes 0.000 claims 1
- 102220021365 rs80357174 Human genes 0.000 claims 1
- 102220106669 rs879255364 Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17483809P | 2009-05-01 | 2009-05-01 | |
| US61/174,838 | 2009-05-01 | ||
| PCT/US2010/033449 WO2010127368A1 (en) | 2009-05-01 | 2010-05-03 | Synthetic oplophorus luciferases with enhanced light output |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015208321A Division JP6227615B2 (ja) | 2009-05-01 | 2015-10-22 | 増大した光出力を有する合成オプロフォルスルシフェラーゼ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012525819A JP2012525819A (ja) | 2012-10-25 |
| JP2012525819A5 true JP2012525819A5 (enExample) | 2013-06-20 |
| JP6038649B2 JP6038649B2 (ja) | 2016-12-07 |
Family
ID=42358981
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012508822A Active JP6038649B2 (ja) | 2009-05-01 | 2010-05-03 | 増大した光出力を有する合成オプロフォルスルシフェラーゼ |
| JP2015208321A Active JP6227615B2 (ja) | 2009-05-01 | 2015-10-22 | 増大した光出力を有する合成オプロフォルスルシフェラーゼ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015208321A Active JP6227615B2 (ja) | 2009-05-01 | 2015-10-22 | 増大した光出力を有する合成オプロフォルスルシフェラーゼ |
Country Status (16)
| Country | Link |
|---|---|
| US (7) | US8557970B2 (enExample) |
| EP (5) | EP3744834B1 (enExample) |
| JP (2) | JP6038649B2 (enExample) |
| KR (1) | KR101665352B1 (enExample) |
| CN (2) | CN102459579B (enExample) |
| AU (1) | AU2010242771B2 (enExample) |
| BR (1) | BRPI1010019B1 (enExample) |
| CA (1) | CA2758572A1 (enExample) |
| DK (4) | DK2456864T3 (enExample) |
| ES (5) | ES2559505T3 (enExample) |
| IL (3) | IL215697B (enExample) |
| LT (1) | LT3409764T (enExample) |
| PL (5) | PL3181687T3 (enExample) |
| PT (4) | PT2990478T (enExample) |
| SG (3) | SG10201901453PA (enExample) |
| WO (1) | WO2010127368A1 (enExample) |
Families Citing this family (75)
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| JP5896679B2 (ja) * | 2011-03-15 | 2016-03-30 | オリンパス株式会社 | オオオバボタル由来ルシフェラーゼ |
| JP6522339B2 (ja) | 2011-11-21 | 2019-05-29 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | カルボキシｘローダミン類似体 |
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| JP2015510598A (ja) | 2012-02-21 | 2015-04-09 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | 微生物の検出のための方法およびシステム |
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| JP6511720B2 (ja) * | 2013-02-28 | 2019-05-15 | Jnc株式会社 | コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法 |
| US11072812B2 (en) | 2013-03-15 | 2021-07-27 | Promega Corporation | Substrates for covalent tethering of proteins to functional groups or solid surfaces |
| US10168323B2 (en) | 2013-03-15 | 2019-01-01 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
| ES2929362T3 (es) | 2013-03-15 | 2022-11-28 | Promega Corp | Activación de la bioluminiscencia mediante complementación estructural |
| AU2014241191A1 (en) | 2013-03-27 | 2015-10-22 | Sample Technologies, Inc. | Recombinant phage and bacterial detection methods |
| JP6040846B2 (ja) | 2013-04-08 | 2016-12-07 | Jnc株式会社 | セレンテラジン類縁体 |
| AU2014281406A1 (en) | 2013-06-19 | 2016-01-21 | Sample6 Technologies, Inc. | Phage-based bacterial detection assay |
| JP6484987B2 (ja) * | 2013-10-21 | 2019-03-20 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
| JP6442825B2 (ja) | 2013-12-26 | 2018-12-26 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
| WO2015116867A1 (en) | 2014-01-29 | 2015-08-06 | Promega Corporation | Quinone-masked probes as labeling reagents for cell uptake measurements |
| US9927430B2 (en) | 2014-01-29 | 2018-03-27 | Promega Corporation | Pro-substrates for live cell applications |
| JP6256118B2 (ja) * | 2014-03-11 | 2018-01-10 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質のキメラ遺伝子及びその使用法 |
| JP6265020B2 (ja) * | 2014-04-16 | 2018-01-24 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
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| EP4455668A3 (en) | 2015-02-05 | 2025-02-19 | Promega Corporation | Luciferase-based thermal shift assays |
| EP3304078B1 (en) | 2015-06-05 | 2022-08-31 | Promega Corporation | Cell-permeable, cell-compatible, and cleavable linkers for covalent tethering of functional elements |
| US10513694B2 (en) | 2015-06-25 | 2019-12-24 | Promega Corporation | Thienopyrrole compounds and uses thereof |
| JP6978492B2 (ja) | 2016-09-09 | 2021-12-08 | プロメガ コーポレイションPromega Corporation | 二重保護されたプロセレンテラジン基質 |
| CA3039406A1 (en) | 2016-09-19 | 2018-03-22 | University Of Southern California | Non-radioactive cytotoxicity assays |
| EP3529616B1 (en) | 2016-10-20 | 2023-09-06 | President and Fellows of Harvard College | In vitro and cell based assays for measuring the activity of botulinum neurotoxins |
| EP4144738A1 (en) | 2016-11-01 | 2023-03-08 | Promega Corporation | Coelenterazine analogues tethered to energy acceptors |
| JP7139330B2 (ja) | 2016-12-01 | 2022-09-20 | プロメガ コーポレイション | 細胞不透過性セレンテラジンアナログ |
| WO2018125992A1 (en) | 2016-12-28 | 2018-07-05 | Promega Corporation | Functionalized nanoluc inhibitors |
| EP3395803A1 (en) | 2017-04-28 | 2018-10-31 | Institut Pasteur | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins |
| JP7269925B2 (ja) * | 2017-10-25 | 2023-05-09 | エフ． ホフマン－ラ ロシュ アーゲー | 改良された遺伝子改変／突然変異型細菌ルシフェラーゼ |
| EP3720975A1 (en) | 2017-12-08 | 2020-10-14 | Centre National de la Recherche Scientifique - CNRS | Bioluminescent screening test for detecting cell cytolysis |
| EP3775240A1 (en) | 2018-03-30 | 2021-02-17 | INVISTA Textiles (U.K.) Limited | Method for controlling dissolved oxygen concentration in a continuous aerobic fermentation |
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| US10975363B2 (en) * | 2018-03-30 | 2021-04-13 | Inv Nylon Chemicals Americas, Llc | Materials and methods for biosynthetic manufacture and utilization of synthetic polypeptides, and products therefrom |
| JP7419260B2 (ja) | 2018-05-01 | 2024-01-22 | プロメガ コーポレイション | ＮａｎｏＬｕｃ自殺基質としてのセレンテラジン化合物 |
| US12060596B2 (en) | 2018-05-02 | 2024-08-13 | Inv Nylon Chemicals Americas, Llc | Materials and methods for controlling limitation conditions in product biosynthesis for non-PHB generating species of the genera Ralstonia or Cupriavidus and organisms related thereto |
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| US10962538B2 (en) | 2018-06-14 | 2021-03-30 | The Trustees Of Columbia University In The City Of New York | Assays using arrestin recruitment and unmodified receptors |
| BR112021006298A2 (pt) | 2018-10-03 | 2021-07-06 | Promega Corp | composições e métodos para estabilizar coelenterazina e análogos e derivados da mesma |
| WO2020113036A2 (en) | 2018-11-28 | 2020-06-04 | Promega Corporation | Reactive peptide labeling |
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| WO2020191339A1 (en) | 2019-03-20 | 2020-09-24 | Promega Corporation | Photoaffinity probes |
| US11360096B2 (en) | 2019-05-16 | 2022-06-14 | Duke University | Complex BRET technique for measuring biological interactions |
| BR112021023617A2 (pt) | 2019-06-21 | 2022-01-04 | Laboratory Corp America Holdings | Métodos para a produção de bacteriófagos mutantes para a detecção de listeria |
| AU2020308448B2 (en) | 2019-06-24 | 2026-04-30 | Promega Corporation | Modified polyamine polymers for delivery of biomolecules into cells |
| JP7781741B2 (ja) | 2019-08-26 | 2025-12-08 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | 組換え繁殖欠損指標バクテリオファージを使用して微生物を検出するためのデバイスおよび方法 |
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| EP4257978A4 (en) | 2020-12-25 | 2024-11-13 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR SCREENING CANDIDATE MOLECULES CAPABLE OF FORMING A COMPLEX IN CONJUNCTION WITH MULTIPLE TARGET MOLECULES |
| CN118703457A (zh) * | 2021-04-01 | 2024-09-27 | 深圳华大生命科学研究院 | 一种刺虾荧光素酶Nluc的突变体及其应用 |
| CN113025586B (zh) * | 2021-04-06 | 2022-10-04 | 湖北省中医院 | 一种经改造的萤光素酶突变体蛋白、生物发光探针、探针组、制备方法和检测方法 |
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| EP4519290A1 (en) | 2022-05-04 | 2025-03-12 | Promega Corporation | Circularly permuted dehalogenase variants |
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| GB202213479D0 (en) | 2022-09-14 | 2022-10-26 | Ipsen Biopharm Ltd | Cell-free clostridial neurotoxin assays |
| WO2024059832A1 (en) * | 2022-09-15 | 2024-03-21 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for assessing kinase activity |
| GB202404021D0 (en) | 2024-03-20 | 2024-05-01 | Ipsen Biopharm Ltd | Cell-based neurotoxin assay |
| CN118516381B (zh) * | 2024-07-22 | 2024-11-01 | 北京剂泰医药科技有限公司 | 编码荧光素酶的mRNA及其应用 |
| CN119709661B (zh) * | 2024-12-30 | 2025-10-10 | 佰翱得(无锡)新药开发有限公司 | 一种荧光素酶OLuc突变体及其应用 |
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2010
- 2010-05-03 DK DK10717013.6T patent/DK2456864T3/en active
- 2010-05-03 PT PT151866522T patent/PT2990478T/pt unknown
- 2010-05-03 BR BRPI1010019A patent/BRPI1010019B1/pt active IP Right Grant
- 2010-05-03 CA CA2758572A patent/CA2758572A1/en active Pending
- 2010-05-03 PL PL17154777T patent/PL3181687T3/pl unknown
- 2010-05-03 EP EP20169057.5A patent/EP3744834B1/en active Active
- 2010-05-03 ES ES10717013.6T patent/ES2559505T3/es active Active
- 2010-05-03 DK DK17154777.1T patent/DK3181687T3/en active
- 2010-05-03 JP JP2012508822A patent/JP6038649B2/ja active Active
- 2010-05-03 AU AU2010242771A patent/AU2010242771B2/en active Active
- 2010-05-03 CN CN201080019477.4A patent/CN102459579B/zh active Active
- 2010-05-03 ES ES20169057T patent/ES3042791T3/es active Active
- 2010-05-03 WO PCT/US2010/033449 patent/WO2010127368A1/en not_active Ceased
- 2010-05-03 ES ES15186652.2T patent/ES2629390T3/es active Active
- 2010-05-03 SG SG10201901453PA patent/SG10201901453PA/en unknown
- 2010-05-03 PT PT181846999T patent/PT3409764T/pt unknown
- 2010-05-03 PT PT17154777T patent/PT3181687T/pt unknown
- 2010-05-03 PL PL18184699T patent/PL3409764T3/pl unknown
- 2010-05-03 PL PL20169057.5T patent/PL3744834T3/pl unknown
- 2010-05-03 US US12/773,002 patent/US8557970B2/en active Active
- 2010-05-03 EP EP18184699.9A patent/EP3409764B1/en active Active
- 2010-05-03 EP EP15186652.2A patent/EP2990478B1/en active Active
- 2010-05-03 DK DK18184699.9T patent/DK3409764T3/da active
- 2010-05-03 PL PL10717013T patent/PL2456864T3/pl unknown
- 2010-05-03 PT PT107170136T patent/PT2456864E/pt unknown
- 2010-05-03 SG SG10201601281WA patent/SG10201601281WA/en unknown
- 2010-05-03 CN CN201810043641.3A patent/CN108192950B/zh active Active
- 2010-05-03 EP EP17154777.1A patent/EP3181687B1/en active Active
- 2010-05-03 ES ES18184699T patent/ES2795287T3/es active Active
- 2010-05-03 KR KR1020117028749A patent/KR101665352B1/ko active Active
- 2010-05-03 PL PL15186652T patent/PL2990478T3/pl unknown
- 2010-05-03 SG SG2011074242A patent/SG175180A1/en unknown
- 2010-05-03 DK DK15186652.2T patent/DK2990478T3/en active
- 2010-05-03 ES ES17154777T patent/ES2691539T3/es active Active
- 2010-05-03 LT LTEP18184699.9T patent/LT3409764T/lt unknown
- 2010-05-03 EP EP10717013.6A patent/EP2456864B1/en active Active
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2011
- 2011-10-11 IL IL215697A patent/IL215697B/en active IP Right Grant
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2013
- 2013-10-14 US US14/053,252 patent/US9777311B2/en active Active
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2015
- 2015-10-22 JP JP2015208321A patent/JP6227615B2/ja active Active
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2017
- 2017-09-25 US US15/714,210 patent/US10233485B2/en active Active
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2019
- 2019-03-06 US US16/294,464 patent/US10633690B2/en active Active
- 2019-03-10 IL IL265263A patent/IL265263B/en active IP Right Grant
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2020
- 2020-03-17 US US16/821,682 patent/US10844422B2/en active Active
- 2020-04-22 IL IL274145A patent/IL274145B/en unknown
- 2020-10-20 US US17/075,415 patent/US11365436B2/en active Active
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2022
- 2022-06-20 US US17/844,371 patent/US11667950B2/en active Active
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