JP2012525819A5 - - Google Patents
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- JP2012525819A5 JP2012525819A5 JP2012508822A JP2012508822A JP2012525819A5 JP 2012525819 A5 JP2012525819 A5 JP 2012525819A5 JP 2012508822 A JP2012508822 A JP 2012508822A JP 2012508822 A JP2012508822 A JP 2012508822A JP 2012525819 A5 JP2012525819 A5 JP 2012525819A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- seq
- amino acid
- positions
- wild
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000040430 polynucleotide Human genes 0.000 claims 17
- 239000002157 polynucleotide Substances 0.000 claims 17
- 108091033319 polynucleotide Proteins 0.000 claims 17
- 108060001084 Luciferase Proteins 0.000 claims 13
- 239000005089 Luciferase Substances 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 238000006467 substitution reaction Methods 0.000 claims 9
- 238000004020 luminiscence type Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 102220531101 Left-right determination factor 1_L92S_mutation Human genes 0.000 claims 1
- 102220492844 Olfactory receptor 8K5_F68S_mutation Human genes 0.000 claims 1
- 102220634786 Potassium voltage-gated channel subfamily A member 3_F77W_mutation Human genes 0.000 claims 1
- 241001284373 Spinus Species 0.000 claims 1
- 102220604980 Transcription factor Sp2_A33K_mutation Human genes 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 102220357107 c.224T>G Human genes 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 102200080930 rs137852221 Human genes 0.000 claims 1
- 102220055135 rs149428656 Human genes 0.000 claims 1
- 102220050200 rs150634297 Human genes 0.000 claims 1
- 102200082940 rs33936254 Human genes 0.000 claims 1
- 102200036809 rs387907341 Human genes 0.000 claims 1
- 102220000379 rs397514441 Human genes 0.000 claims 1
- 102220087238 rs541028076 Human genes 0.000 claims 1
- 102220025301 rs587778874 Human genes 0.000 claims 1
- 102220045199 rs587781908 Human genes 0.000 claims 1
- 102220058220 rs730881937 Human genes 0.000 claims 1
- 102220101693 rs771554497 Human genes 0.000 claims 1
- 102200137195 rs7897309 Human genes 0.000 claims 1
- 102220021365 rs80357174 Human genes 0.000 claims 1
- 102220106669 rs879255364 Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17483809P | 2009-05-01 | 2009-05-01 | |
| US61/174,838 | 2009-05-01 | ||
| PCT/US2010/033449 WO2010127368A1 (en) | 2009-05-01 | 2010-05-03 | Synthetic oplophorus luciferases with enhanced light output |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015208321A Division JP6227615B2 (ja) | 2009-05-01 | 2015-10-22 | 増大した光出力を有する合成オプロフォルスルシフェラーゼ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012525819A JP2012525819A (ja) | 2012-10-25 |
| JP2012525819A5 true JP2012525819A5 (enExample) | 2013-06-20 |
| JP6038649B2 JP6038649B2 (ja) | 2016-12-07 |
Family
ID=42358981
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012508822A Active JP6038649B2 (ja) | 2009-05-01 | 2010-05-03 | 増大した光出力を有する合成オプロフォルスルシフェラーゼ |
| JP2015208321A Active JP6227615B2 (ja) | 2009-05-01 | 2015-10-22 | 増大した光出力を有する合成オプロフォルスルシフェラーゼ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015208321A Active JP6227615B2 (ja) | 2009-05-01 | 2015-10-22 | 増大した光出力を有する合成オプロフォルスルシフェラーゼ |
Country Status (16)
| Country | Link |
|---|---|
| US (7) | US8557970B2 (enExample) |
| EP (5) | EP3744834B1 (enExample) |
| JP (2) | JP6038649B2 (enExample) |
| KR (1) | KR101665352B1 (enExample) |
| CN (2) | CN108192950B (enExample) |
| AU (1) | AU2010242771B2 (enExample) |
| BR (1) | BRPI1010019B1 (enExample) |
| CA (1) | CA2758572A1 (enExample) |
| DK (4) | DK2990478T3 (enExample) |
| ES (5) | ES3042791T3 (enExample) |
| IL (3) | IL215697B (enExample) |
| LT (1) | LT3409764T (enExample) |
| PL (4) | PL3409764T3 (enExample) |
| PT (4) | PT2990478T (enExample) |
| SG (3) | SG10201901453PA (enExample) |
| WO (1) | WO2010127368A1 (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101665352B1 (ko) | 2009-05-01 | 2016-10-12 | 프로메가 코포레이션 | 광 출력이 향상된 합성 오플로포러스 루시퍼라제 |
| AU2011323418B2 (en) | 2010-11-02 | 2017-07-27 | Promega Corporation | Novel coelenterazine substrates and methods of use |
| EP2635583B1 (en) | 2010-11-02 | 2015-06-03 | Promega Corporation | Coelenterazine derivatives and methods of using same |
| JP5896679B2 (ja) * | 2011-03-15 | 2016-03-30 | オリンパス株式会社 | オオオバボタル由来ルシフェラーゼ |
| EP2782916B1 (en) | 2011-11-21 | 2018-02-28 | Promega Corporation | Carboxy x rhodamine analogs |
| US10519483B2 (en) | 2012-02-21 | 2019-12-31 | Laboratory Corporation Of America Holdings | Methods and systems for rapid detection of microorganisms using infectious agents |
| MX382157B (es) | 2012-02-21 | 2025-03-13 | Laboratory Corp America Holdings | Metodos y sistemas para deteccion de microorganismos. |
| WO2014052653A1 (en) | 2012-09-26 | 2014-04-03 | Promega Corporation | Real-time monitoring |
| KR102272233B1 (ko) | 2012-12-12 | 2021-07-01 | 프로메가 코포레이션 | 생체활성 제제의 세포 표적 포획을 위한 조성물 및 방법 |
| US10024862B2 (en) * | 2012-12-12 | 2018-07-17 | Promega Corporation | Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer |
| US10067149B2 (en) | 2012-12-12 | 2018-09-04 | Promega Corporation | Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer |
| JP6511720B2 (ja) | 2013-02-28 | 2019-05-15 | Jnc株式会社 | コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法 |
| US11072811B2 (en) | 2013-03-15 | 2021-07-27 | Promega Corporation | Substrates for covalent tethering of proteins to functional groups or solid surfaces |
| ES2926463T3 (es) | 2013-03-15 | 2022-10-26 | Promega Corp | Activación de la bioluminiscencia mediante complementación estructural |
| US10168323B2 (en) | 2013-03-15 | 2019-01-01 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
| EP2978857A2 (en) | 2013-03-27 | 2016-02-03 | Sample Technologies, Inc. | Recombinant phage and bacterial detection methods |
| JP6040846B2 (ja) | 2013-04-08 | 2016-12-07 | Jnc株式会社 | セレンテラジン類縁体 |
| CA2915820A1 (en) | 2013-06-19 | 2014-12-24 | Michael Sandor Koeris | Phage-based bacterial detection assay |
| JP6484987B2 (ja) * | 2013-10-21 | 2019-03-20 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
| JP6442825B2 (ja) | 2013-12-26 | 2018-12-26 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
| US9927430B2 (en) | 2014-01-29 | 2018-03-27 | Promega Corporation | Pro-substrates for live cell applications |
| JP6703484B2 (ja) | 2014-01-29 | 2020-06-03 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 細胞による取り込み測定のための、標識用試薬としての、キノンでマスクされたプローブ |
| JP6256118B2 (ja) * | 2014-03-11 | 2018-01-10 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質のキメラ遺伝子及びその使用法 |
| JP6265020B2 (ja) | 2014-04-16 | 2018-01-24 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
| US9732373B2 (en) | 2014-09-11 | 2017-08-15 | Promega Corporation | Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence |
| US11365402B2 (en) | 2014-09-12 | 2022-06-21 | Promega Corporation | Internal protein tags |
| EP3191601B1 (en) * | 2014-09-12 | 2022-11-02 | Promega Corporation | Internal protein tags |
| WO2016127100A1 (en) | 2015-02-05 | 2016-08-11 | Promega Corporation | Luciferase-based thermal shift assays |
| JP6876002B2 (ja) | 2015-06-05 | 2021-05-26 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 機能的要素を共有結合により係留させるための細胞透過性、細胞適合性、かつ開裂可能であるリンカー |
| EP3313846B1 (en) | 2015-06-25 | 2020-05-06 | Promega Corporation | Thienopyrrole compounds and uses thereof as inhibitors of oplophorus-derived luciferases |
| US10316070B2 (en) | 2016-09-09 | 2019-06-11 | Promega Corporation | Dual protected pro-coelenterazine substrates |
| US11307205B2 (en) | 2016-09-19 | 2022-04-19 | University Of Southern California | Non-radioactive cytotoxicity assays |
| KR102556363B1 (ko) | 2016-10-20 | 2023-07-18 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 보툴리눔 신경독소의 활성을 측정하기 위한 시험관내 및 세포 기반 검정 |
| JP7200102B2 (ja) | 2016-11-01 | 2023-01-06 | プロメガ コーポレイション | エネルギー受容体に係留されたセレンテラジン類縁体 |
| DK3548492T5 (en) | 2016-12-01 | 2024-08-05 | Promega Corp | Cell impermeable coelenterazine analogues |
| JP7161475B2 (ja) | 2016-12-28 | 2022-10-26 | プロメガ コーポレイション | 官能化ｎａｎｏｌｕｃ阻害剤 |
| JP7269925B2 (ja) * | 2017-10-25 | 2023-05-09 | エフ． ホフマン－ラ ロシュ アーゲー | 改良された遺伝子改変／突然変異型細菌ルシフェラーゼ |
| US20200393446A1 (en) | 2017-12-08 | 2020-12-17 | Centre National De La Recherche Scientifique (Cnrs) | Bioluminescent screening test for detecting cell cytolysis |
| EP3775182A1 (en) * | 2018-03-30 | 2021-02-17 | INVISTA Textiles (U.K.) Limited | Materials and methods for biosynthetic manufacture of pimelic acid and utilization of synthetic polypeptides |
| EP3775242A1 (en) | 2018-03-30 | 2021-02-17 | INVISTA Textiles (U.K.) Limited | High hydrogen utilization and gas recycle |
| EP3775240A1 (en) | 2018-03-30 | 2021-02-17 | INVISTA Textiles (U.K.) Limited | Method for controlling dissolved oxygen concentration in a continuous aerobic fermentation |
| WO2019213119A1 (en) | 2018-05-01 | 2019-11-07 | Promega Corporation | Coelenterazine compounds as nanoluc suicide substrates |
| EP3788156A1 (en) | 2018-05-02 | 2021-03-10 | INVISTA Textiles (U.K.) Limited | Methods for controlling limitation conditions in product biosynthesis for non-phb generating cupriavidus or ralstonia |
| WO2019213033A1 (en) | 2018-05-02 | 2019-11-07 | Invista North America S.A.R.L. | Materials and methods for maximizing biosynthesis through alteration of pyruvate-acetyl-coa-tca balance in species of the genera ralstonia and cupriavidus and organisms related thereto |
| US11442063B2 (en) | 2018-05-30 | 2022-09-13 | Promega Corporation | Broad spectrum kinase binding agents |
| US11390599B2 (en) | 2018-06-01 | 2022-07-19 | Promega Corporation | Inhibitors of oplophorus luciferase-derived bioluminescent complexes |
| US10962538B2 (en) | 2018-06-14 | 2021-03-30 | The Trustees Of Columbia University In The City Of New York | Assays using arrestin recruitment and unmodified receptors |
| CN119955899A (zh) | 2018-10-03 | 2025-05-09 | 普洛麦格公司 | 用于稳定腔肠素及其类似物和衍生物的组合物、方法和试剂盒 |
| JP7703446B2 (ja) | 2018-11-28 | 2025-07-07 | プロメガ コーポレイション | 反応性ペプチド標識付け |
| JP7634479B2 (ja) | 2018-12-04 | 2025-02-21 | プロメガ コーポレイション | 広域スペクトルｇｐｃｒ結合剤 |
| JP7584433B2 (ja) | 2019-03-20 | 2024-11-15 | プロメガ コーポレイション | 光親和性プローブ |
| US11360096B2 (en) | 2019-05-16 | 2022-06-14 | Duke University | Complex BRET technique for measuring biological interactions |
| JP2022536960A (ja) | 2019-06-21 | 2022-08-22 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | Ｌｉｓｔｅｒｉａの検出のための変異体バクテリオファージを生成するための方法 |
| CN114450326B (zh) | 2019-06-24 | 2025-02-11 | 普罗美加公司 | 用于将生物分子递送到细胞中的改性聚胺聚合物 |
| JP7781741B2 (ja) | 2019-08-26 | 2025-12-08 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | 組換え繁殖欠損指標バクテリオファージを使用して微生物を検出するためのデバイスおよび方法 |
| US11591633B2 (en) | 2019-09-11 | 2023-02-28 | Laboratory Corporation Of America Holdings | Methods and systems for the rapid detection of bacteria using recombinant bacteriophage to express an indicator subunit |
| BR112022010153A2 (pt) | 2019-11-27 | 2022-08-09 | Promega Corp | Peptídeos, ácido nucleico, polipeptídeo, composição, complexo bioluminescente, métodos, dipeptídeo, sistema e kit |
| EP4073512B1 (en) | 2019-12-10 | 2025-11-12 | Promega Corporation | Compositions and methods for bioluminescent detection using multifunctional probes |
| CA3168897A1 (en) | 2020-01-28 | 2021-08-05 | Freeline Therapeutics Limited | Improved assay for determining neutralising antibody titre to a viral vektor |
| US20210363565A1 (en) | 2020-05-22 | 2021-11-25 | Promega Corporation | Enhancement of kinase target engagement |
| US20220064696A1 (en) | 2020-08-28 | 2022-03-03 | Promega Corporation | Target engagement assay for ras proteins |
| EP4257978A4 (en) | 2020-12-25 | 2024-11-13 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR SCREENING CANDIDATE MOLECULES CAPABLE OF FORMING A COMPLEX IN CONJUNCTION WITH MULTIPLE TARGET MOLECULES |
| CN118703457A (zh) * | 2021-04-01 | 2024-09-27 | 深圳华大生命科学研究院 | 一种刺虾荧光素酶Nluc的突变体及其应用 |
| CN113025586B (zh) * | 2021-04-06 | 2022-10-04 | 湖北省中医院 | 一种经改造的萤光素酶突变体蛋白、生物发光探针、探针组、制备方法和检测方法 |
| US20230357266A1 (en) | 2022-05-04 | 2023-11-09 | Promega Corporation | Photoactivatable compounds and uses thereof |
| JP2025515181A (ja) | 2022-05-04 | 2025-05-13 | プロメガ コーポレイション | 伸長表面ループ領域を有する修飾デハロゲナーゼ |
| US20240174992A1 (en) | 2022-05-04 | 2024-05-30 | Promega Corporation | Split modified dehalogenase variants |
| JP2025515179A (ja) | 2022-05-04 | 2025-05-13 | プロメガ コーポレイション | 円順列置換デハロゲナーゼバリアント |
| GB202213479D0 (en) | 2022-09-14 | 2022-10-26 | Ipsen Biopharm Ltd | Cell-free clostridial neurotoxin assays |
| WO2024059832A1 (en) * | 2022-09-15 | 2024-03-21 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for assessing kinase activity |
| GB202404021D0 (en) | 2024-03-20 | 2024-05-01 | Ipsen Biopharm Ltd | Cell-based neurotoxin assay |
| CN119307519B (zh) * | 2024-07-22 | 2025-11-25 | 苏州剂泰医药科技有限公司 | 编码荧光素酶的mRNA及其应用 |
| CN119709661B (zh) * | 2024-12-30 | 2025-10-10 | 佰翱得(无锡)新药开发有限公司 | 一种荧光素酶OLuc突变体及其应用 |
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| GB8911957D0 (en) | 1989-05-24 | 1989-07-12 | Interox Chemicals Ltd | Peroxyacid manufacture |
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| JP5684984B2 (ja) * | 2006-04-03 | 2015-03-18 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 順列置換及び非順列置換ルシフェラーゼバイオセンサー |
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| KR101665352B1 (ko) | 2009-05-01 | 2016-10-12 | 프로메가 코포레이션 | 광 출력이 향상된 합성 오플로포러스 루시퍼라제 |
| AU2011323418B2 (en) * | 2010-11-02 | 2017-07-27 | Promega Corporation | Novel coelenterazine substrates and methods of use |
-
2010
- 2010-05-03 KR KR1020117028749A patent/KR101665352B1/ko active Active
- 2010-05-03 SG SG10201901453PA patent/SG10201901453PA/en unknown
- 2010-05-03 PT PT151866522T patent/PT2990478T/pt unknown
- 2010-05-03 SG SG10201601281WA patent/SG10201601281WA/en unknown
- 2010-05-03 EP EP20169057.5A patent/EP3744834B1/en active Active
- 2010-05-03 PT PT181846999T patent/PT3409764T/pt unknown
- 2010-05-03 EP EP18184699.9A patent/EP3409764B1/en active Active
- 2010-05-03 PL PL18184699T patent/PL3409764T3/pl unknown
- 2010-05-03 ES ES20169057T patent/ES3042791T3/es active Active
- 2010-05-03 CA CA2758572A patent/CA2758572A1/en active Pending
- 2010-05-03 ES ES15186652.2T patent/ES2629390T3/es active Active
- 2010-05-03 PL PL10717013T patent/PL2456864T3/pl unknown
- 2010-05-03 PT PT107170136T patent/PT2456864E/pt unknown
- 2010-05-03 DK DK15186652.2T patent/DK2990478T3/en active
- 2010-05-03 US US12/773,002 patent/US8557970B2/en active Active
- 2010-05-03 AU AU2010242771A patent/AU2010242771B2/en active Active
- 2010-05-03 ES ES18184699T patent/ES2795287T3/es active Active
- 2010-05-03 PT PT17154777T patent/PT3181687T/pt unknown
- 2010-05-03 LT LTEP18184699.9T patent/LT3409764T/lt unknown
- 2010-05-03 WO PCT/US2010/033449 patent/WO2010127368A1/en not_active Ceased
- 2010-05-03 ES ES10717013.6T patent/ES2559505T3/es active Active
- 2010-05-03 DK DK17154777.1T patent/DK3181687T3/en active
- 2010-05-03 BR BRPI1010019A patent/BRPI1010019B1/pt active IP Right Grant
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