DK3409764T3 - Syntetiske oplophorus-luciferaser med forbedret lysudbytte - Google Patents
Syntetiske oplophorus-luciferaser med forbedret lysudbytte Download PDFInfo
- Publication number
- DK3409764T3 DK3409764T3 DK18184699.9T DK18184699T DK3409764T3 DK 3409764 T3 DK3409764 T3 DK 3409764T3 DK 18184699 T DK18184699 T DK 18184699T DK 3409764 T3 DK3409764 T3 DK 3409764T3
- Authority
- DK
- Denmark
- Prior art keywords
- improved light
- light exchange
- oplophorus luciferases
- synthetic oplophorus
- synthetic
- Prior art date
Links
- 108060001084 Luciferase Proteins 0.000 title 1
- 241001443978 Oplophorus Species 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
- C12Y113/12—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)(1.13.12)
- C12Y113/12007—Photinus-luciferin 4-monooxygenase (ATP-hydrolysing) (1.13.12.7), i.e. firefly-luciferase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17483809P | 2009-05-01 | 2009-05-01 | |
EP17154777.1A EP3181687B1 (en) | 2009-05-01 | 2010-05-03 | Synthetic oplophorus luciferases with enhanced light output |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3409764T3 true DK3409764T3 (da) | 2020-05-25 |
Family
ID=42358981
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18184699.9T DK3409764T3 (da) | 2009-05-01 | 2010-05-03 | Syntetiske oplophorus-luciferaser med forbedret lysudbytte |
DK15186652.2T DK2990478T3 (da) | 2009-05-01 | 2010-05-03 | Syntetiske oplophorus-luciferaser med forbedret lysemission |
DK10717013.6T DK2456864T3 (da) | 2009-05-01 | 2010-05-03 | Syntetiske oplophorus-luciferaser med forbedret lysemission |
DK17154777.1T DK3181687T3 (da) | 2009-05-01 | 2010-05-03 | Syntetiske oplophorus-luciferaser med forøget lysudbytte |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15186652.2T DK2990478T3 (da) | 2009-05-01 | 2010-05-03 | Syntetiske oplophorus-luciferaser med forbedret lysemission |
DK10717013.6T DK2456864T3 (da) | 2009-05-01 | 2010-05-03 | Syntetiske oplophorus-luciferaser med forbedret lysemission |
DK17154777.1T DK3181687T3 (da) | 2009-05-01 | 2010-05-03 | Syntetiske oplophorus-luciferaser med forøget lysudbytte |
Country Status (16)
Country | Link |
---|---|
US (7) | US8557970B2 (da) |
EP (5) | EP3181687B1 (da) |
JP (2) | JP6038649B2 (da) |
KR (1) | KR101665352B1 (da) |
CN (2) | CN102459579B (da) |
AU (1) | AU2010242771B2 (da) |
BR (1) | BRPI1010019B1 (da) |
CA (1) | CA2758572A1 (da) |
DK (4) | DK3409764T3 (da) |
ES (4) | ES2559505T3 (da) |
IL (3) | IL215697B (da) |
LT (1) | LT3409764T (da) |
PL (4) | PL3181687T3 (da) |
PT (4) | PT3181687T (da) |
SG (3) | SG175180A1 (da) |
WO (1) | WO2010127368A1 (da) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL3181687T3 (pl) | 2009-05-01 | 2018-11-30 | Promega Corporation | Syntetyczne lucyferazy z krewetki oplophorus emitującej bardziej intensywne światło |
BR112013010484B1 (pt) | 2010-11-02 | 2019-09-03 | Promega Corp | derivados de coelenterazina e métodos de utilizar os mesmos |
SG190104A1 (en) | 2010-11-02 | 2013-06-28 | Promega Corp | Oplophorus-derived luciferases, novel coelenterazine substrates, and methods of use |
JP5896679B2 (ja) * | 2011-03-15 | 2016-03-30 | オリンパス株式会社 | オオオバボタル由来ルシフェラーゼ |
WO2013078244A1 (en) | 2011-11-21 | 2013-05-30 | Promega Corporation | Carboxy x rhodamine analogs |
US10519483B2 (en) | 2012-02-21 | 2019-12-31 | Laboratory Corporation Of America Holdings | Methods and systems for rapid detection of microorganisms using infectious agents |
WO2013126584A1 (en) | 2012-02-21 | 2013-08-29 | Laboratory Corporation Of America Holdings | Methods and systems for detection of microorganisms |
WO2014052653A1 (en) | 2012-09-26 | 2014-04-03 | Promega Corporation | Real-time monitoring |
US10067149B2 (en) | 2012-12-12 | 2018-09-04 | Promega Corporation | Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer |
EP2931305B1 (en) * | 2012-12-12 | 2018-11-28 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
WO2014093677A1 (en) | 2012-12-12 | 2014-06-19 | Promega Corporation | Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer |
JP6511720B2 (ja) | 2013-02-28 | 2019-05-15 | Jnc株式会社 | コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法 |
DK2970412T3 (da) | 2013-03-15 | 2022-08-29 | Promega Corp | Aktivering af bioluminescens via strukturel komplementering |
US10168323B2 (en) * | 2013-03-15 | 2019-01-01 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
US11072811B2 (en) | 2013-03-15 | 2021-07-27 | Promega Corporation | Substrates for covalent tethering of proteins to functional groups or solid surfaces |
US9340817B2 (en) | 2013-03-27 | 2016-05-17 | Sample6 Technologies, Inc. | Methods of making recombinant phage, compositions and articles of manufacture of same for bacterial detection |
JP6040846B2 (ja) | 2013-04-08 | 2016-12-07 | Jnc株式会社 | セレンテラジン類縁体 |
WO2014205221A2 (en) | 2013-06-19 | 2014-12-24 | Sample6 Technologies, Inc. | Phage-based bacterial detection assay |
JP6484987B2 (ja) | 2013-10-21 | 2019-03-20 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
JP6442825B2 (ja) * | 2013-12-26 | 2018-12-26 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
WO2015116867A1 (en) | 2014-01-29 | 2015-08-06 | Promega Corporation | Quinone-masked probes as labeling reagents for cell uptake measurements |
WO2015116806A1 (en) | 2014-01-29 | 2015-08-06 | Promega Corporation | Pro-substrates for live cell applications |
JP6256118B2 (ja) | 2014-03-11 | 2018-01-10 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質のキメラ遺伝子及びその使用法 |
JP6265020B2 (ja) | 2014-04-16 | 2018-01-24 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
JP6811173B2 (ja) | 2014-09-11 | 2021-01-13 | プロメガ コーポレイションPromega Corporation | 増強された発光を産生するために赤外発光基質を活用するルシフェラーゼ配列 |
US11365402B2 (en) | 2014-09-12 | 2022-06-21 | Promega Corporation | Internal protein tags |
JP6814132B2 (ja) * | 2014-09-12 | 2021-01-13 | プロメガ コーポレイションPromega Corporation | 内部タンパク質タグ |
EP3254113A4 (en) | 2015-02-05 | 2018-06-27 | Promega Corporation | Luciferase-based thermal shift assays |
US10618907B2 (en) | 2015-06-05 | 2020-04-14 | Promega Corporation | Cell-permeable, cell-compatible, and cleavable linkers for covalent tethering of functional elements |
WO2016210294A1 (en) | 2015-06-25 | 2016-12-29 | Promega Corporation | Thienopyrrole compounds and uses thereof as inhibitors of oplophorus-derived luciferases |
EP3510035B1 (en) | 2016-09-09 | 2021-04-07 | Promega Corporation | Dual protected pro-coelenterazine substrates |
CA3039406A1 (en) | 2016-09-19 | 2018-03-22 | University Of Southern California | Non-radioactive cytotoxicity assays |
PL3529616T3 (pl) | 2016-10-20 | 2024-03-18 | President And Fellows Of Harvard College | Testy in vitro i komórkowe do pomiaru aktywności neurotoksyn botulinowych |
US10280447B2 (en) | 2016-11-01 | 2019-05-07 | Promega Corporation | Substituted imidazo[1,2-A]pyrazines tethered to energy acceptors |
US10577370B2 (en) | 2016-12-01 | 2020-03-03 | Promega Corporation | Cell impermeable coelenterazine analogues |
US10815247B2 (en) | 2016-12-28 | 2020-10-27 | Promega Corporation | Functionalized NANOLUC inhibitors |
EP3701014A1 (en) | 2017-10-25 | 2020-09-02 | Roche Diagnostics GmbH | Improved modified/mutant bacterial luciferases |
EP3720975A1 (en) | 2017-12-08 | 2020-10-14 | Centre National de la Recherche Scientifique - CNRS | Bioluminescent screening test for detecting cell cytolysis |
WO2019191770A1 (en) * | 2018-03-30 | 2019-10-03 | Invista North America S.A.R.L. | Materials and methods for biosynthetic manufacture of pimelic acid and utilization of synthetic polypeptides |
US11655247B2 (en) | 2018-05-01 | 2023-05-23 | Promega Corporation | Nanoluc suicide substrates |
US11702680B2 (en) | 2018-05-02 | 2023-07-18 | Inv Nylon Chemicals Americas, Llc | Materials and methods for controlling PHA biosynthesis in PHA-generating species of the genera Ralstonia or Cupriavidus and organisms related thereto |
JP7432529B2 (ja) | 2018-05-30 | 2024-02-16 | プロメガ コーポレイション | 広域スペクトルキナーゼ結合剤 |
JP7357009B2 (ja) | 2018-06-01 | 2023-10-05 | プロメガ コーポレイション | Oplophorusルシフェラーゼ由来生物発光性複合体の阻害剤 |
US10962538B2 (en) | 2018-06-14 | 2021-03-30 | The Trustees Of Columbia University In The City Of New York | Assays using arrestin recruitment and unmodified receptors |
US11534504B2 (en) | 2018-10-03 | 2022-12-27 | Promega Corporation | Compositions and methods for stabilizing coelenterazine and analogs and derivatives thereof |
WO2020113036A2 (en) | 2018-11-28 | 2020-06-04 | Promega Corporation | Reactive peptide labeling |
WO2020117954A2 (en) | 2018-12-04 | 2020-06-11 | Promega Corporation | Broad spectrum gpcr binding agents |
EP3941195A4 (en) | 2019-03-20 | 2023-03-22 | Promega Corporation | PHOTOAFFINITY PROBES |
US11360096B2 (en) | 2019-05-16 | 2022-06-14 | Duke University | Complex BRET technique for measuring biological interactions |
US11674124B2 (en) | 2019-06-21 | 2023-06-13 | Laboratory Corporation Of America Holdings | Methods for producing mutant bacteriophages for the detection of listeria |
AU2020308448A1 (en) | 2019-06-24 | 2022-02-03 | Promega Corporation | Modified polyamine polymers for delivery of biomolecules into cells |
CN114729332A (zh) | 2019-08-26 | 2022-07-08 | 美国控股实验室公司 | 用于使用重组繁殖缺陷性指示噬菌体检测微生物的装置和方法 |
CA3150337A1 (en) | 2019-09-11 | 2021-03-18 | Stephen E. Erickson | METHODS AND SYSTEMS FOR THE RAPID DETECTION OF MICROORGANISMS USING RECOMBINANT INFECTIOUS AGENTS TO EXPRESS AN INDICATOR SUBUNIT |
BR112022010153A2 (pt) | 2019-11-27 | 2022-08-09 | Promega Corp | Peptídeos, ácido nucleico, polipeptídeo, composição, complexo bioluminescente, métodos, dipeptídeo, sistema e kit |
WO2021119149A1 (en) | 2019-12-10 | 2021-06-17 | Promega Corporation | Compositions and methods for bioluminescent detection using multifunctional probes |
KR20220133969A (ko) | 2020-01-28 | 2022-10-05 | 프리라인 테라퓨틱스 리미티드 | 바이러스 벡터에 대한 중화 항체 역가를 결정하기 위한 개선된 분석법 |
WO2021237118A2 (en) | 2020-05-22 | 2021-11-25 | Promega Corporation | Enhancement of kinase target engagement |
EP4204808A1 (en) | 2020-08-28 | 2023-07-05 | Promega Corporation | Target engagement assay for ras proteins |
TW202242415A (zh) | 2020-12-25 | 2022-11-01 | 日商中外製藥股份有限公司 | 能夠與複數的目標分子共同形成複合體之候補分子的篩選方法 |
CN113025586B (zh) * | 2021-04-06 | 2022-10-04 | 湖北省中医院 | 一种经改造的萤光素酶突变体蛋白、生物发光探针、探针组、制备方法和检测方法 |
WO2023215452A2 (en) | 2022-05-04 | 2023-11-09 | Promega Corporation | Split modified dehalogenase variants |
WO2023215432A1 (en) | 2022-05-04 | 2023-11-09 | Promega Corporation | Circularly permuted dehalogenase variants |
WO2023215505A1 (en) | 2022-05-04 | 2023-11-09 | Promega Corporation | Modified dehalogenase with extended surface loop regions |
WO2023215514A2 (en) | 2022-05-04 | 2023-11-09 | Promega Corporation | Bioluminescence-triggered photocatalytic labeling |
GB202213479D0 (en) | 2022-09-14 | 2022-10-26 | Ipsen Biopharm Ltd | Cell-free clostridial neurotoxin assays |
WO2024059832A1 (en) * | 2022-09-15 | 2024-03-21 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for assessing kinase activity |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8911957D0 (en) | 1989-05-24 | 1989-07-12 | Interox Chemicals Ltd | Peroxyacid manufacture |
US5368484A (en) | 1992-05-22 | 1994-11-29 | Atari Games Corp. | Vehicle simulator with realistic operating feedback |
ES2301160T3 (es) * | 1994-01-03 | 2008-06-16 | Promega Corporation | Luciferasas mutantes. |
WO1999014336A2 (en) | 1997-09-19 | 1999-03-25 | Promega Corporation | Thermostable luciferases and methods of production |
JP3694181B2 (ja) * | 1999-01-05 | 2005-09-14 | キッコーマン株式会社 | 変異型ルシフェラーゼ、変異型ルシフェラーゼ遺伝子、新規な組み換え体dna及び変異型ルシフェラーゼの製造法 |
WO2001031028A2 (en) | 1999-10-26 | 2001-05-03 | The Secretary Of State For Defence | Mutant luciferase |
DE60142761D1 (de) * | 2000-04-26 | 2010-09-23 | Chisso Corp | Oplophorus Luciferase |
JP4613441B2 (ja) * | 2000-04-26 | 2011-01-19 | チッソ株式会社 | 新規ルシフェラーゼおよび発光蛋白質 |
US7118878B1 (en) * | 2000-06-09 | 2006-10-10 | Promega Corporation | Method for increasing luminescence assay sensitivity |
US7268229B2 (en) | 2001-11-02 | 2007-09-11 | Promega Corporation | Compounds to co-localize luminophores with luminescent proteins |
CA2489804C (en) | 2002-06-19 | 2008-03-25 | Medical Instill Technologies, Inc. | Sterile filling machine having needle filling station within e-beam chamber |
CA2561809A1 (en) * | 2004-03-31 | 2005-10-20 | Xencor, Inc. | Bmp-7 variants with improved properties |
JP3844082B2 (ja) * | 2005-04-08 | 2006-11-08 | キッコーマン株式会社 | 耐熱性ホタルルシフェラーゼ、耐熱性ホタルルシフェラーゼ遺伝子、新規な組み換え体dna及び耐熱性ホタルルシフェラーゼの製造法 |
JP4999341B2 (ja) | 2005-09-06 | 2012-08-15 | 株式会社バイオエネックス | 変異型ホタルルシフェラーゼ、遺伝子、組換えベクター、形質転換体、及び変異型ホタルルシフェラーゼの製造方法 |
EP2327768B1 (en) * | 2006-04-03 | 2015-09-09 | Promega Corporation | Permuted and nonpermuted luciferase biosensors |
US20080248511A1 (en) * | 2007-03-26 | 2008-10-09 | Promega Corporation | Methods to quench light from optical reactions |
WO2009061413A2 (en) * | 2007-11-05 | 2009-05-14 | Promega Corporation | Hybrid fusion reporter and uses thereof |
EP2281046B1 (en) * | 2008-05-19 | 2012-01-25 | Promega Corporation | LUCIFERASE BIOSENSORS FOR cAMP |
WO2010119721A1 (ja) * | 2009-04-17 | 2010-10-21 | 独立行政法人産業技術総合研究所 | 超高輝度で安定な人工生物発光酵素 |
PL3181687T3 (pl) | 2009-05-01 | 2018-11-30 | Promega Corporation | Syntetyczne lucyferazy z krewetki oplophorus emitującej bardziej intensywne światło |
SG190104A1 (en) * | 2010-11-02 | 2013-06-28 | Promega Corp | Oplophorus-derived luciferases, novel coelenterazine substrates, and methods of use |
-
2010
- 2010-05-03 PL PL17154777T patent/PL3181687T3/pl unknown
- 2010-05-03 SG SG2011074242A patent/SG175180A1/en unknown
- 2010-05-03 SG SG10201901453PA patent/SG10201901453PA/en unknown
- 2010-05-03 BR BRPI1010019A patent/BRPI1010019B1/pt active IP Right Grant
- 2010-05-03 KR KR1020117028749A patent/KR101665352B1/ko active IP Right Grant
- 2010-05-03 EP EP17154777.1A patent/EP3181687B1/en active Active
- 2010-05-03 WO PCT/US2010/033449 patent/WO2010127368A1/en active Application Filing
- 2010-05-03 LT LTEP18184699.9T patent/LT3409764T/lt unknown
- 2010-05-03 CA CA2758572A patent/CA2758572A1/en active Pending
- 2010-05-03 EP EP15186652.2A patent/EP2990478B1/en active Active
- 2010-05-03 EP EP18184699.9A patent/EP3409764B1/en active Active
- 2010-05-03 ES ES10717013.6T patent/ES2559505T3/es active Active
- 2010-05-03 DK DK18184699.9T patent/DK3409764T3/da active
- 2010-05-03 PT PT17154777T patent/PT3181687T/pt unknown
- 2010-05-03 EP EP10717013.6A patent/EP2456864B1/en active Active
- 2010-05-03 PL PL18184699T patent/PL3409764T3/pl unknown
- 2010-05-03 PT PT107170136T patent/PT2456864E/pt unknown
- 2010-05-03 ES ES17154777T patent/ES2691539T3/es active Active
- 2010-05-03 AU AU2010242771A patent/AU2010242771B2/en active Active
- 2010-05-03 ES ES15186652.2T patent/ES2629390T3/es active Active
- 2010-05-03 CN CN201080019477.4A patent/CN102459579B/zh active Active
- 2010-05-03 US US12/773,002 patent/US8557970B2/en active Active
- 2010-05-03 PT PT181846999T patent/PT3409764T/pt unknown
- 2010-05-03 JP JP2012508822A patent/JP6038649B2/ja active Active
- 2010-05-03 DK DK15186652.2T patent/DK2990478T3/da active
- 2010-05-03 PT PT151866522T patent/PT2990478T/pt unknown
- 2010-05-03 PL PL15186652T patent/PL2990478T3/pl unknown
- 2010-05-03 DK DK10717013.6T patent/DK2456864T3/da active
- 2010-05-03 SG SG10201601281WA patent/SG10201601281WA/en unknown
- 2010-05-03 ES ES18184699T patent/ES2795287T3/es active Active
- 2010-05-03 DK DK17154777.1T patent/DK3181687T3/da active
- 2010-05-03 CN CN201810043641.3A patent/CN108192950B/zh active Active
- 2010-05-03 PL PL10717013T patent/PL2456864T3/pl unknown
- 2010-05-03 EP EP20169057.5A patent/EP3744834A1/en active Pending
-
2011
- 2011-10-11 IL IL215697A patent/IL215697B/en active IP Right Grant
-
2013
- 2013-10-14 US US14/053,252 patent/US9777311B2/en active Active
-
2015
- 2015-10-22 JP JP2015208321A patent/JP6227615B2/ja active Active
-
2017
- 2017-09-25 US US15/714,210 patent/US10233485B2/en active Active
-
2019
- 2019-03-06 US US16/294,464 patent/US10633690B2/en active Active
- 2019-03-10 IL IL265263A patent/IL265263B/en active IP Right Grant
-
2020
- 2020-03-17 US US16/821,682 patent/US10844422B2/en active Active
- 2020-04-22 IL IL274145A patent/IL274145B/en unknown
- 2020-10-20 US US17/075,415 patent/US11365436B2/en active Active
-
2022
- 2022-06-20 US US17/844,371 patent/US11667950B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK3409764T3 (da) | Syntetiske oplophorus-luciferaser med forbedret lysudbytte | |
DK2479264T3 (da) | Glucoamylasevarianter med ændrede egenskaber | |
BRPI0920450A2 (pt) | Pirrolobenzodiazepinas | |
BRPI0914657A2 (pt) | piridin-2-onae piridazin-3-onas substituídas | |
BRPI0913501A2 (pt) | carrinho de bebê | |
DK2376490T3 (da) | Imidazopyridinforbindelser | |
BRPI1005796A2 (pt) | rolo de exercício | |
DK2280734T3 (da) | Faktor-ix-konjugater med forlængede halveringstider | |
BRPI0917570A2 (pt) | artigo absorvente incluindo um núcleo absorvente com regiões absorventes concentricamente dispostas | |
DK2282055T3 (da) | Kommunikerende energilagre med forskellige funktioner | |
BRPI0918823A2 (pt) | beta-glicosidases modificadas com estabilidades aperfeicoada | |
DE112010001215A5 (de) | Gurtaufrollersystem mit einsteuerglied | |
DE102009028982A8 (de) | Difluoroboradiazaindacen-Farbstoffe | |
BRPI0822548A2 (pt) | Disposição em recipiente dotado de fechadura | |
FI20086158A0 (fi) | Imidatsopyridiinijohdannaiset | |
BRPI0914538A2 (pt) | derivados tricíclicos substituídos | |
DE112009003820A5 (de) | Schmuckstück mit schwenkbaren teilen | |
BRPI0915995A2 (pt) | veículo abastecedor | |
DK2236023T3 (da) | Stald med gulvelement | |
DK2408289T3 (da) | Vendeplov med forbedret omsvingningsmekanisme | |
FR2944701B1 (fr) | Composition coloree. | |
IT1390861B1 (it) | Composti ad attività antimalarica | |
BRPI1013544A2 (pt) | compostos com efeito fisiológico | |
ES1071336Y (es) | Sillon provisto de bandeja amovible | |
DE112010003029A5 (de) | Leuchtmittel mit LED |