JP2012512175A5 - - Google Patents
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- JP2012512175A5 JP2012512175A5 JP2011540968A JP2011540968A JP2012512175A5 JP 2012512175 A5 JP2012512175 A5 JP 2012512175A5 JP 2011540968 A JP2011540968 A JP 2011540968A JP 2011540968 A JP2011540968 A JP 2011540968A JP 2012512175 A5 JP2012512175 A5 JP 2012512175A5
- Authority
- JP
- Japan
- Prior art keywords
- nanoparticle composition
- biocompatible
- biocompatible nanoparticle
- composition according
- therapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002105 nanoparticle Substances 0.000 claims 27
- 239000000203 mixture Substances 0.000 claims 20
- 239000003814 drug Substances 0.000 claims 9
- 229940124597 therapeutic agent Drugs 0.000 claims 9
- 229920000249 biocompatible polymer Polymers 0.000 claims 5
- 230000008685 targeting Effects 0.000 claims 5
- 239000004721 Polyphenylene oxide Substances 0.000 claims 4
- 150000001720 carbohydrates Chemical class 0.000 claims 4
- 229920000570 polyether Polymers 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 230000036470 plasma concentration Effects 0.000 claims 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims 3
- 239000004626 polylactic acid Substances 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229920002988 biodegradable polymer Polymers 0.000 claims 2
- 239000004621 biodegradable polymer Substances 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 1
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 102000004856 Lectins Human genes 0.000 claims 1
- 108090001090 Lectins Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 102000007451 Steroid Receptors Human genes 0.000 claims 1
- 108010085012 Steroid Receptors Proteins 0.000 claims 1
- -1 antibody Proteins 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000012830 cancer therapeutic Substances 0.000 claims 1
- 239000002458 cell surface marker Substances 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 229940124452 immunizing agent Drugs 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 239000002858 neurotransmitter agent Substances 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- JFINOWIINSTUNY-UHFFFAOYSA-N pyrrolidin-3-ylmethanesulfonamide Chemical compound NS(=O)(=O)CC1CCNC1 JFINOWIINSTUNY-UHFFFAOYSA-N 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- 229960004528 vincristine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12247908P | 2008-12-15 | 2008-12-15 | |
| US61/122,479 | 2008-12-15 | ||
| US24902209P | 2009-10-06 | 2009-10-06 | |
| US61/249,022 | 2009-10-06 | ||
| US26020009P | 2009-11-11 | 2009-11-11 | |
| US61/260,200 | 2009-11-11 | ||
| PCT/US2009/068028 WO2010075072A2 (en) | 2008-12-15 | 2009-12-15 | Long circulating nanoparticles for sustained release of therapeutic agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015088181A Division JP2015143268A (ja) | 2008-12-15 | 2015-04-23 | 治療薬を徐放するための長時間循環性ナノ粒子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012512175A JP2012512175A (ja) | 2012-05-31 |
| JP2012512175A5 true JP2012512175A5 (enExample) | 2013-02-07 |
Family
ID=42288375
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540968A Pending JP2012512175A (ja) | 2008-12-15 | 2009-12-15 | 治療薬を徐放するための長時間循環性ナノ粒子 |
| JP2015088181A Withdrawn JP2015143268A (ja) | 2008-12-15 | 2015-04-23 | 治療薬を徐放するための長時間循環性ナノ粒子 |
| JP2017125985A Withdrawn JP2017165780A (ja) | 2008-12-15 | 2017-06-28 | 治療薬を徐放するための長時間循環性ナノ粒子 |
| JP2019081186A Pending JP2019142924A (ja) | 2008-12-15 | 2019-04-22 | 治療薬を徐放するための長時間循環性ナノ粒子 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015088181A Withdrawn JP2015143268A (ja) | 2008-12-15 | 2015-04-23 | 治療薬を徐放するための長時間循環性ナノ粒子 |
| JP2017125985A Withdrawn JP2017165780A (ja) | 2008-12-15 | 2017-06-28 | 治療薬を徐放するための長時間循環性ナノ粒子 |
| JP2019081186A Pending JP2019142924A (ja) | 2008-12-15 | 2019-04-22 | 治療薬を徐放するための長時間循環性ナノ粒子 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US20100216804A1 (enExample) |
| EP (1) | EP2379064B1 (enExample) |
| JP (4) | JP2012512175A (enExample) |
| EA (1) | EA201100765A1 (enExample) |
| ES (1) | ES2776126T3 (enExample) |
| WO (1) | WO2010075072A2 (enExample) |
Families Citing this family (190)
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| WO2008105773A2 (en) | 2006-03-31 | 2008-09-04 | Massachusetts Institute Of Technology | System for targeted delivery of therapeutic agents |
| WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| US9217129B2 (en) | 2007-02-09 | 2015-12-22 | Massachusetts Institute Of Technology | Oscillating cell culture bioreactor |
| US20090074828A1 (en) | 2007-04-04 | 2009-03-19 | Massachusetts Institute Of Technology | Poly(amino acid) targeting moieties |
| ATE530169T1 (de) | 2007-09-28 | 2011-11-15 | Bind Biosciences Inc | Krebszellen-targeting mit nanopartikeln |
| MX2010003642A (es) | 2007-10-12 | 2010-08-09 | Massachusetts Inst Technology | Nanotecnologia de vacuna. |
| EA020753B1 (ru) | 2008-06-16 | 2015-01-30 | Бинд Терапьютикс, Инк. | Терапевтические полимерные наночастицы, содержащие алкалоиды vinca, и их применение |
| WO2010005726A2 (en) | 2008-06-16 | 2010-01-14 | Bind Biosciences Inc. | Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same |
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-
2009
- 2009-12-15 EA EA201100765A patent/EA201100765A1/ru unknown
- 2009-12-15 WO PCT/US2009/068028 patent/WO2010075072A2/en not_active Ceased
- 2009-12-15 EP EP09835578.7A patent/EP2379064B1/en active Active
- 2009-12-15 JP JP2011540968A patent/JP2012512175A/ja active Pending
- 2009-12-15 US US12/638,297 patent/US20100216804A1/en not_active Abandoned
- 2009-12-15 ES ES09835578T patent/ES2776126T3/es active Active
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2011
- 2011-05-16 US US13/108,361 patent/US20110217377A1/en not_active Abandoned
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2012
- 2012-07-24 US US13/556,647 patent/US9308179B2/en active Active
-
2013
- 2013-12-09 US US14/100,695 patent/US9198874B2/en active Active
-
2015
- 2015-04-23 JP JP2015088181A patent/JP2015143268A/ja not_active Withdrawn
- 2015-10-26 US US14/922,755 patent/US20160045608A1/en not_active Abandoned
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2017
- 2017-06-28 JP JP2017125985A patent/JP2017165780A/ja not_active Withdrawn
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2019
- 2019-04-22 JP JP2019081186A patent/JP2019142924A/ja active Pending
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