JP2012511023A5 - - Google Patents
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- JP2012511023A5 JP2012511023A5 JP2011539755A JP2011539755A JP2012511023A5 JP 2012511023 A5 JP2012511023 A5 JP 2012511023A5 JP 2011539755 A JP2011539755 A JP 2011539755A JP 2011539755 A JP2011539755 A JP 2011539755A JP 2012511023 A5 JP2012511023 A5 JP 2012511023A5
- Authority
- JP
- Japan
- Prior art keywords
- integer
- compound
- pharmaceutically acceptable
- tissue
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12022608P | 2008-12-05 | 2008-12-05 | |
| US61/120,226 | 2008-12-05 | ||
| US18034109P | 2009-05-21 | 2009-05-21 | |
| US61/180,341 | 2009-05-21 | ||
| PCT/US2009/066836 WO2010065902A2 (en) | 2008-12-05 | 2009-12-04 | Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof for inhibiting psma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012511023A JP2012511023A (ja) | 2012-05-17 |
| JP2012511023A5 true JP2012511023A5 (enExample) | 2012-11-01 |
| JP5220203B2 JP5220203B2 (ja) | 2013-06-26 |
Family
ID=42076951
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011539755A Active JP5220203B2 (ja) | 2008-12-05 | 2009-12-04 | テクネチウム−及びレニウム−ビス（ヘテロアリール）錯体及びｐｓｍａを阻害するその使用方法 |
| JP2011539752A Pending JP2012511022A (ja) | 2008-12-05 | 2009-12-04 | テクネチウム及びレニウム−ビス（ヘテロアリール）錯体及びその使用方法 |
| JP2011539757A Ceased JP2012511024A (ja) | 2008-12-05 | 2009-12-04 | 癌の治療及び撮像用のｃａ−ｉｘ特異性放射性医薬品 |
| JP2014145241A Active JP5856247B2 (ja) | 2008-12-05 | 2014-07-15 | テクネチウム及びレニウム−ビス（ヘテロアリール）錯体及びその使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011539752A Pending JP2012511022A (ja) | 2008-12-05 | 2009-12-04 | テクネチウム及びレニウム−ビス（ヘテロアリール）錯体及びその使用方法 |
| JP2011539757A Ceased JP2012511024A (ja) | 2008-12-05 | 2009-12-04 | 癌の治療及び撮像用のｃａ−ｉｘ特異性放射性医薬品 |
| JP2014145241A Active JP5856247B2 (ja) | 2008-12-05 | 2014-07-15 | テクネチウム及びレニウム−ビス（ヘテロアリール）錯体及びその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8211401B2 (enExample) |
| EP (4) | EP2389361B1 (enExample) |
| JP (4) | JP5220203B2 (enExample) |
| CN (3) | CN102272101A (enExample) |
| AU (3) | AU2009322167B2 (enExample) |
| BR (3) | BRPI0922779A8 (enExample) |
| CA (3) | CA2745918C (enExample) |
| ES (2) | ES2574514T3 (enExample) |
| HU (2) | HUE029940T2 (enExample) |
| PL (2) | PL2706057T3 (enExample) |
| RU (3) | RU2539565C2 (enExample) |
| TW (3) | TW201034689A (enExample) |
| WO (1) | WO2010065902A2 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2187965T3 (da) | 2007-08-17 | 2020-01-20 | Purdue Research Foundation | Psma-bindingsligand-linker-konjugater og fremgangsmåder til anvendelse |
| WO2009084995A1 (en) | 2007-12-28 | 2009-07-09 | Exini Diagnostics Ab | System for detecting bone cancer metastases |
| CA2711678A1 (en) * | 2008-01-09 | 2009-07-16 | Molecular Insight Pharmaceuticals, Inc. | Inhibitors of carbonic anhydrase ix |
| WO2010065899A2 (en) | 2008-12-05 | 2010-06-10 | Molecular Insight Pharmaceuticals, Inc. | Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof |
| AU2009322167B2 (en) * | 2008-12-05 | 2014-11-20 | Molecular Insight Pharmaceuticals, Inc. | Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof for inhibiting PSMA |
| US8211402B2 (en) | 2008-12-05 | 2012-07-03 | Molecular Insight Pharmaceuticals, Inc. | CA-IX specific radiopharmaceuticals for the treatment and imaging of cancer |
| BR112012000209B8 (pt) | 2009-06-15 | 2021-07-27 | Molecular Insight Pharm Inc | heterodímeros de ácido glutâmico e seus processos de preparação |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| US9687572B2 (en) | 2010-12-06 | 2017-06-27 | Molecular Insight Pharmaceuticals, Inc. | PSMA-targeted dendrimers |
| JP5843338B2 (ja) * | 2011-08-05 | 2016-01-13 | モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド | 放射標識された前立腺特異的膜抗原阻害剤 |
| US10011632B2 (en) | 2011-08-22 | 2018-07-03 | Siemens Medical Solutions Usa, Inc. | PSMA imaging agents |
| EP2785712B1 (en) | 2011-11-30 | 2019-05-01 | The Johns Hopkins University | Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (pmsa) and uses thereof |
| US9120837B2 (en) | 2012-01-06 | 2015-09-01 | Molecular Insight Pharmaceuticals | Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase IX |
| FR2989085A1 (fr) * | 2012-04-05 | 2013-10-11 | Commissariat Energie Atomique | Radiotraceurs, procedes de preparation et applications |
| KR102318999B1 (ko) | 2012-11-15 | 2021-10-29 | 엔도사이트, 인코포레이티드 | Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트 |
| HUE035739T2 (en) * | 2013-01-14 | 2018-05-28 | Molecular Insight Pharm Inc | Triazine-based radiopharmaceuticals and radiological imaging agents |
| US10233179B2 (en) * | 2013-04-22 | 2019-03-19 | Abbvie Inc. | Thiazoles and uses thereof |
| EP3057620A4 (en) * | 2013-10-18 | 2017-05-24 | Molecular Insight Pharmaceuticals, Inc. | Methods of using spect/ct analysis for staging cancer |
| AU2014336638C1 (en) | 2013-10-18 | 2020-09-17 | Novartis Ag | Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| WO2015073678A1 (en) | 2013-11-14 | 2015-05-21 | Endocyte, Inc. | Compounds for positron emission tomography |
| EP2993171A1 (en) * | 2014-09-04 | 2016-03-09 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for the production of 18F-labeled PSMA-specific PET-tracers |
| JP2017530109A (ja) | 2014-09-08 | 2017-10-12 | モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド | 前立腺癌についてのｐｓｍａを標的とした放射性核種治療中の臓器の保護 |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| PL3356385T3 (pl) | 2015-09-30 | 2021-06-28 | Deutsches Krebsforschungszentrum | Tagowane 18F inhibitory antygenu błonowego specyficznego dla gruczołu krokowego (PSMA) i ich zastosowanie jako środków do obrazowania w nowotworze gruczołu krokowego |
| KR101639599B1 (ko) * | 2015-11-09 | 2016-07-14 | 서울대학교산학협력단 | 펩타이드 싸이오우레아 유도체, 이를 포함하는 방사성 동위원소 표지 화합물 및 이를 유효 성분으로 함유하는 전립선암 치료 또는 진단용 약학적 조성물 |
| EP3192810A1 (en) * | 2016-01-14 | 2017-07-19 | Deutsches Krebsforschungszentrum | Psma binding antibody and uses thereof |
| CN105510511B (zh) * | 2016-01-23 | 2017-04-12 | 河北科技大学 | 一种2‑氨基丁醇对映异构体的hplc分离检测方法 |
| KR20250057132A (ko) * | 2016-03-22 | 2025-04-28 | 더 존스 홉킨스 유니버시티 | 전립선 암의 내부방사선요법을 위한 전립선-특이적 막 항원 표적화된 고-친화성 제제 |
| US10806806B2 (en) | 2016-06-23 | 2020-10-20 | Cornell University | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies |
| SG11201811482YA (en) * | 2016-06-23 | 2019-01-30 | Univ Cornell | Double targeted constructs to affect tumor kill |
| EP4636783A3 (en) | 2016-10-27 | 2025-12-24 | Progenics Pharmaceuticals, Inc. | Network for medical image analysis, decision support system, and related graphical user interface (gui) applications |
| KR102724812B1 (ko) | 2017-04-05 | 2024-11-01 | 코넬 유니버시티 | 영상화 및 항종양 치료요법에 유용한 조정 가능한 약동학을 갖는 삼작용성 작제물 |
| US11478558B2 (en) * | 2017-05-30 | 2022-10-25 | The Johns Hopkins University | Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer |
| DK3498308T3 (da) | 2017-12-13 | 2025-01-02 | Sciencons AS | Kompleks, der omfatter en psma-målrettet forbindelse bundet til et bly- eller thorium-radionuklid |
| ES3026214T3 (en) | 2018-01-08 | 2025-06-10 | Progenics Pharm Inc | System and method for rapid neural network-based image segmentation |
| US12602772B2 (en) | 2018-01-08 | 2026-04-14 | Progenics Pharmaceuticals, Inc. | Systems and methods for rapid neural network-based image segmentation and radiopharmaceutical uptake determination |
| US10973486B2 (en) | 2018-01-08 | 2021-04-13 | Progenics Pharmaceuticals, Inc. | Systems and methods for rapid neural network-based image segmentation and radiopharmaceutical uptake determination |
| WO2019157037A1 (en) * | 2018-02-06 | 2019-08-15 | The Johns Hopkins University | Psma targeted radiohalogenated urea-polyaminocarboxylates for cancer radiotherapy |
| RU2692126C1 (ru) * | 2018-02-13 | 2019-06-21 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) | Способ получения производного мочевины с хелатным центром, тропного к простат-специфичному мембранному антигену для связывания технеция-99м/рения для диагностики/лечения рака предстательной железы |
| MX2020010813A (es) | 2018-04-17 | 2021-01-08 | Endocyte Inc | Metodos de tratamiento de cancer. |
| WO2019246445A1 (en) * | 2018-06-20 | 2019-12-26 | The Research Foundation For The State University Of New York | Triazamacrocycle-derived chelator compositions for coordination of imaging and therapy metal ions and methods of using same |
| WO2020045638A1 (ja) * | 2018-08-30 | 2020-03-05 | 日本メジフィジックス株式会社 | 放射性イミダゾチアジアゾール誘導体化合物 |
| JP7568628B2 (ja) | 2019-01-07 | 2024-10-16 | エクシーニ ディアグノスティクス アーべー | プラットホーム非依存の全身画像セグメント化のためのシステムおよび方法 |
| CN113748443B (zh) | 2019-04-24 | 2025-09-09 | 普罗热尼奇制药公司 | 用于交互式调整核医学图像中的强度窗口设定的系统和方法 |
| CA3136127A1 (en) | 2019-04-24 | 2020-10-29 | Progenics Pharmaceuticals, Inc. | Systems and methods for automated and interactive analysis of bone scan images for detection of metastases |
| EP3972627A4 (en) | 2019-05-20 | 2023-06-21 | Endocyte, Inc. | Methods for preparing psma conjugates |
| US11900597B2 (en) | 2019-09-27 | 2024-02-13 | Progenics Pharmaceuticals, Inc. | Systems and methods for artificial intelligence-based image analysis for cancer assessment |
| US12417533B2 (en) | 2019-09-27 | 2025-09-16 | Progenics Pharmaceuticals, Inc. | Systems and methods for artificial intelligence-based image analysis for cancer assessment |
| US11544407B1 (en) | 2019-09-27 | 2023-01-03 | Progenics Pharmaceuticals, Inc. | Systems and methods for secure cloud-based medical image upload and processing |
| US11564621B2 (en) | 2019-09-27 | 2023-01-31 | Progenies Pharmacenticals, Inc. | Systems and methods for artificial intelligence-based image analysis for cancer assessment |
| US11321844B2 (en) | 2020-04-23 | 2022-05-03 | Exini Diagnostics Ab | Systems and methods for deep-learning-based segmentation of composite images |
| US11386988B2 (en) | 2020-04-23 | 2022-07-12 | Exini Diagnostics Ab | Systems and methods for deep-learning-based segmentation of composite images |
| TWI920110B (zh) | 2020-07-06 | 2026-04-01 | 瑞典商艾西尼診斷公司 | 用於偵測及表徵化病變之基於人工智慧的影像分析系統與方法 |
| US11721428B2 (en) | 2020-07-06 | 2023-08-08 | Exini Diagnostics Ab | Systems and methods for artificial intelligence-based image analysis for detection and characterization of lesions |
| WO2022106629A1 (en) | 2020-11-19 | 2022-05-27 | Novartis Ag | Synthesis of prostate specific membrane antigen (psma) ligands |
| CA3212963A1 (en) * | 2021-04-23 | 2022-10-27 | Reinier HERNANDEZ | Psma-targeting ligands with optimal properties for imaging and therapy |
| US12597127B2 (en) | 2021-10-08 | 2026-04-07 | Exini Diagnostics Ab | Systems and methods for automated identification and classification of lesions in local lymph and distant metastases |
| JP7893555B2 (ja) * | 2021-12-24 | 2026-07-22 | エルジー エナジー ソリューション リミテッド | 正極活物質、これを含む正極およびリチウム二次電池 |
| EP4537301A2 (en) | 2022-06-08 | 2025-04-16 | Progenics Pharmaceuticals, Inc. | Systems and methods for assessing disease burden and progression |
| US20240285248A1 (en) | 2023-02-13 | 2024-08-29 | Progenics Pharmaceuticals, Inc. | Systems and methods for predicting biochemical progression free survival in prostate cancer patients |
| US20240354940A1 (en) | 2023-04-07 | 2024-10-24 | Progenics Pharmaceuticals, Inc. | Systems and methods for facilitating lesion inspection and analysis |
| EP4785275A1 (en) | 2023-09-25 | 2026-08-05 | Progenics Pharmaceuticals, Inc. | Systems and methods for automated cancer staging and risk prediction |
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| WO2010065899A2 (en) * | 2008-12-05 | 2010-06-10 | Molecular Insight Pharmaceuticals, Inc. | Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof |
-
2009
- 2009-12-04 AU AU2009322167A patent/AU2009322167B2/en active Active
- 2009-12-04 EP EP09775429.5A patent/EP2389361B1/en active Active
- 2009-12-04 CA CA2745918A patent/CA2745918C/en active Active
- 2009-12-04 CN CN2009801538771A patent/CN102272101A/zh active Pending
- 2009-12-04 EP EP09765209A patent/EP2373621A2/en not_active Withdrawn
- 2009-12-04 ES ES13195617.9T patent/ES2574514T3/es active Active
- 2009-12-04 CN CN200980153722.8A patent/CN102272100B/zh active Active
- 2009-12-04 BR BRPI0922779A patent/BRPI0922779A8/pt active Search and Examination
- 2009-12-04 HU HUE13195617A patent/HUE029940T2/en unknown
- 2009-12-04 CN CN2009801538786A patent/CN102272102A/zh active Pending
- 2009-12-04 AU AU2009322164A patent/AU2009322164B2/en active Active
- 2009-12-04 PL PL13195617.9T patent/PL2706057T3/pl unknown
- 2009-12-04 ES ES09775429.5T patent/ES2595128T3/es active Active
- 2009-12-04 PL PL09775429T patent/PL2389361T3/pl unknown
- 2009-12-04 TW TW098141532A patent/TW201034689A/zh unknown
- 2009-12-04 JP JP2011539755A patent/JP5220203B2/ja active Active
- 2009-12-04 EP EP09775430A patent/EP2373622A2/en not_active Withdrawn
- 2009-12-04 RU RU2011127467/04A patent/RU2539565C2/ru not_active IP Right Cessation
- 2009-12-04 JP JP2011539752A patent/JP2012511022A/ja active Pending
- 2009-12-04 TW TW098141540A patent/TW201034691A/zh unknown
- 2009-12-04 RU RU2011127462/04A patent/RU2539584C2/ru active
- 2009-12-04 BR BRPI0922839-0A patent/BRPI0922839A2/pt not_active IP Right Cessation
- 2009-12-04 AU AU2009322171A patent/AU2009322171A1/en not_active Abandoned
- 2009-12-04 RU RU2011127468/04A patent/RU2532912C2/ru active
- 2009-12-04 EP EP14155382.6A patent/EP2759535A1/en not_active Withdrawn
- 2009-12-04 WO PCT/US2009/066836 patent/WO2010065902A2/en not_active Ceased
- 2009-12-04 US US12/631,337 patent/US8211401B2/en active Active
- 2009-12-04 TW TW098141536A patent/TW201034690A/zh unknown
- 2009-12-04 BR BRPI0922840A patent/BRPI0922840A2/pt active IP Right Grant
- 2009-12-04 CA CA2745955A patent/CA2745955C/en active Active
- 2009-12-04 CA CA2745958A patent/CA2745958A1/en not_active Abandoned
- 2009-12-04 HU HUE09775429A patent/HUE030681T2/en unknown
- 2009-12-04 JP JP2011539757A patent/JP2012511024A/ja not_active Ceased
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2014
- 2014-07-15 JP JP2014145241A patent/JP5856247B2/ja active Active
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