JP2004536811A5 - - Google Patents

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Publication number
JP2004536811A5
JP2004536811A5 JP2003501466A JP2003501466A JP2004536811A5 JP 2004536811 A5 JP2004536811 A5 JP 2004536811A5 JP 2003501466 A JP2003501466 A JP 2003501466A JP 2003501466 A JP2003501466 A JP 2003501466A JP 2004536811 A5 JP2004536811 A5 JP 2004536811A5
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JP
Japan
Prior art keywords
alkanoyl
alkyl
cycloalkenyl
cycloalkyl
linker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003501466A
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English (en)
Japanese (ja)
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JP2004536811A (ja
JP4814486B2 (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2002/017613 external-priority patent/WO2002098427A2/en
Publication of JP2004536811A publication Critical patent/JP2004536811A/ja
Publication of JP2004536811A5 publication Critical patent/JP2004536811A5/ja
Application granted granted Critical
Publication of JP4814486B2 publication Critical patent/JP4814486B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2003501466A 2001-06-05 2002-06-05 持続放出性鎮痛性化合物 Expired - Fee Related JP4814486B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29555601P 2001-06-05 2001-06-05
US60/295,556 2001-06-05
PCT/US2002/017613 WO2002098427A2 (en) 2001-06-05 2002-06-05 Sustained-release analgesic compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010089721A Division JP2010155869A (ja) 2001-06-05 2010-04-08 持続放出性鎮痛性化合物

Publications (3)

Publication Number Publication Date
JP2004536811A JP2004536811A (ja) 2004-12-09
JP2004536811A5 true JP2004536811A5 (enExample) 2010-06-24
JP4814486B2 JP4814486B2 (ja) 2011-11-16

Family

ID=23138201

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003501466A Expired - Fee Related JP4814486B2 (ja) 2001-06-05 2002-06-05 持続放出性鎮痛性化合物
JP2010089721A Withdrawn JP2010155869A (ja) 2001-06-05 2010-04-08 持続放出性鎮痛性化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010089721A Withdrawn JP2010155869A (ja) 2001-06-05 2010-04-08 持続放出性鎮痛性化合物

Country Status (15)

Country Link
US (1) US20030022876A1 (enExample)
EP (2) EP1709957A3 (enExample)
JP (2) JP4814486B2 (enExample)
KR (1) KR20040014544A (enExample)
CN (1) CN1514729B (enExample)
AR (1) AR034362A1 (enExample)
AT (1) ATE506064T1 (enExample)
AU (1) AU2002305816B2 (enExample)
BR (1) BR0210179A (enExample)
CA (1) CA2448665C (enExample)
DE (1) DE60239801D1 (enExample)
IL (1) IL158882A0 (enExample)
NZ (1) NZ529661A (enExample)
TW (1) TWI255186B (enExample)
WO (1) WO2002098427A2 (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040022853A1 (en) * 2001-04-26 2004-02-05 Control Delivery Systems, Inc. Polymer-based, sustained release drug delivery system
KR20040005936A (ko) * 2001-04-26 2004-01-16 컨트롤 딜리버리 시스템즈 인코포레이티드 공동약물을 함유하는 서방 약물 전달 시스템
IN2014DN10834A (enExample) * 2001-09-17 2015-09-04 Psivida Inc
TW200500067A (en) * 2003-01-21 2005-01-01 Control Delivery Sys Inc Salts of codrugs and uses related thereto
ATE454169T1 (de) * 2003-03-13 2010-01-15 Controlled Chemicals Inc Oxycodon- konjugate mit niedrigerem missbrauch- potential und ausgedehnter tätigkeitsdauer
WO2004112838A2 (en) * 2003-05-21 2004-12-29 Control Delivery Systems, Inc. Codrugs of diclofenac
TW201509943A (zh) * 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
EP1838317A4 (en) * 2005-01-05 2012-02-29 Univ Minnesota ANALGICAL CONJUGATES
US20060281775A1 (en) * 2005-06-14 2006-12-14 Applied Pharmacy Services, Inc. Two-component pharmaceutical composition for the treatment of pain
EP1829878A1 (de) 2006-03-02 2007-09-05 Universitätsklinikum Freiburg Neue Morphinverbindungen für pharmazeutische Zusammensetzungen
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
US20090082314A1 (en) * 2007-06-29 2009-03-26 The Provost Fellows And Scholars Of The College Of The Targeting Prodrugs for the Treatment of Gastrointestinal Diseases
EP2067858A1 (en) 2007-12-07 2009-06-10 Universidad de Sevilla Animal models for neurodegenerative diseases
AU2009249071A1 (en) 2008-05-20 2009-11-26 Neurogesx, Inc. Hepatoprotectant acetaminophen mutual prodrugs
JP5519645B2 (ja) 2008-05-20 2014-06-11 ニューロジェシックス， インコーポレイテッド カーボネートプロドラッグおよびそれを使用する方法
BRPI0912326A2 (pt) 2008-05-20 2015-10-06 Neurogesx Inc análogos de acetaminofeno hidrossolúveis
AU2009292631A1 (en) * 2008-09-16 2010-03-25 Nektar Therapeutics Pegylated opioids with low potential for abuse
ES2589915T3 (es) * 2008-10-08 2016-11-17 Xgene Pharmaceutical Inc Conjugados de GABA y métodos de utilización de los mismos
FR2939436B1 (fr) * 2008-12-10 2010-12-17 Sanofi Aventis Synthese de morphine-6-glucuronide ou de l'un de ses derives
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
AU2010266209B2 (en) * 2009-07-02 2013-09-26 Kempharm, Inc. Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof
CN104136031B (zh) 2011-10-26 2016-05-04 凯姆制药公司 氢吗啡酮的苯甲酸缀合物、苯甲酸衍生物缀合物和杂芳基羧酸缀合物、其前药、制备和使用方法
US9295731B2 (en) * 2013-04-01 2016-03-29 Mark Quang Nguyen Cleavable drug conjugates, compositions thereof and methods of use
KR101616998B1 (ko) * 2014-03-18 2016-04-29 전남대학교병원 오피오이드 진통제 및 p7c3를 포함하는 진통제 조성물
WO2016086113A1 (en) 2014-11-25 2016-06-02 Kempharm, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone
RU2683274C2 (ru) * 2014-12-02 2019-03-27 Кемфарм, Инк. Бензойная кислота, производные бензойной кислоты и конъюгаты гетероарилкарбоновой кислоты и оксиморфона, их пролекарства, способы получения и применение
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
CN107033154B (zh) * 2016-02-02 2020-02-04 上海瀚迈生物医药科技有限公司 阿片受体拮抗剂缀合物及其应用
CN113429306A (zh) * 2016-08-26 2021-09-24 江苏恩华药业股份有限公司 一种地佐辛晶型a及其制备方法
JP2020536955A (ja) 2017-10-06 2020-12-17 ファウンドリー セラピューティクス， インコーポレイテッド 治療剤の制御放出のための埋込み可能なデポー
CN111655303A (zh) 2018-01-08 2020-09-11 铸造疗法股份有限公司 经由治疗剂的控制递送用于治疗腔内癌症的装置、系统和方法
CN112367980A (zh) 2018-05-12 2021-02-12 铸造疗法股份有限公司 用于控制释放治疗剂的可植入贮库
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
CN112867484A (zh) 2018-08-28 2021-05-28 铸造疗法股份有限公司 聚合物植入物
CN109096191B (zh) * 2018-10-25 2022-03-08 西北工业大学 氟比洛芬美普他酚酯药用化合物及其制备方法
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods
KR102665346B1 (ko) * 2022-01-04 2024-05-13 한국생명공학연구원 신규한 디클로로페녹시아세트산 유도체 및 이의 용도
CN117567477A (zh) * 2023-11-15 2024-02-20 宜昌人福药业有限责任公司 一种氢吗啡酮和二氢吗啡类药物低分子聚乙二醇化物及其制备方法和应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2999102A (en) * 1959-10-14 1961-09-05 Thomae Gmbh Dr K Bis-(steroid-21)-dicarboxylic acid esters
US3147183A (en) * 1962-04-16 1964-09-01 Boehringer Sohn Ingelheim Bis-(steroid-21)-dicarboxylic acid esters
FR2576213B1 (fr) * 1985-01-21 1989-02-24 Cortial Nouveau procede d'obtention de formes pharmaceutiques a liberation prolongee
JPH0232027A (ja) * 1988-07-19 1990-02-01 Rooman Kogyo:Kk 鎮痛剤
TW225536B (enExample) * 1990-08-23 1994-06-21 Ciba Geigy Ag
US5681964A (en) * 1990-10-23 1997-10-28 University Of Kentucky Research Foundation Permeable, non-irritating prodrugs of nonsteroidal and steroidal agents
SE9003665D0 (sv) * 1990-11-16 1990-11-16 Kabivitrum Ab Morphine prodrugs
GB9116909D0 (en) * 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
JPH07505634A (ja) * 1992-04-06 1995-06-22 バイオサイト・ダイアグノスティックス・インコーポレイテッド 新規オピエート誘導体，タンパクおよびポリペプチドオピエート誘導共役体および標識
JPH06271578A (ja) * 1993-03-15 1994-09-27 Natl Sci Council 鎮痛剤ナルブフィン前薬の誘導体
FR2708611B1 (fr) * 1993-07-29 1995-10-27 Meram Lab Sel de codéine de l'acide 2-(3-benzoylphényl)propionique, procédé d'obtention et compositions pharmaceutiques le contenant.
FI960504A0 (fi) * 1993-08-02 1996-02-02 Commw Scient Ind Res Org Menetelmä terapeuttisten yhdisteiden ja rasvahappojen muodostamien konjugaattien valmistamiseksi
US6051576A (en) * 1994-01-28 2000-04-18 University Of Kentucky Research Foundation Means to achieve sustained release of synergistic drugs by conjugation
BR9607492A (pt) * 1995-01-16 1999-06-29 Commw Scient Ind Res Org Conjugados de ácidos graxos de composto terapêutico
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
US5840731A (en) * 1995-08-02 1998-11-24 Virginia Commonwealth University Pain-alleviating drug composition and method for alleviating pain
DE19607395C2 (de) * 1996-02-28 2002-11-21 Lohmann Therapie Syst Lts Salze aus einem kationischen narkotischen Analgetikum mit einem anionischen nichtnarkotischen Analgetikum, Verfahren zu deren Herstellung und die diese Salze enthaltenden pharmazeutischen Präparate
ZA979404B (en) * 1996-10-21 1998-06-01 Cal Internat Ltd Aspirinate compounds.
US6225321B1 (en) * 1997-06-05 2001-05-01 Oliver Yoa-Pu Hu Long analgesic acting nalbuphine polyester derivative and method of use
US6667299B1 (en) * 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
US6306842B1 (en) * 2000-06-02 2001-10-23 Medinox, Inc. Protected forms of a combination of pharmacologically active agents and uses therefor
EP1448231A1 (en) * 2001-11-19 2004-08-25 Control Delivery Systems, Inc. Topical delivery of codrugs
MXPA04006875A (es) * 2002-01-18 2004-12-06 Control Delivery Sys Inc Sistema de gel polimerico para suministro controlado de cofarmacos.

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