NZ529661A - Sustained-release analgesic compounds - Google Patents
Sustained-release analgesic compoundsInfo
- Publication number
- NZ529661A NZ529661A NZ529661A NZ52966102A NZ529661A NZ 529661 A NZ529661 A NZ 529661A NZ 529661 A NZ529661 A NZ 529661A NZ 52966102 A NZ52966102 A NZ 52966102A NZ 529661 A NZ529661 A NZ 529661A
- Authority
- NZ
- New Zealand
- Prior art keywords
- analgesic
- sustained
- moieties
- analgesic compounds
- steroidal anti
- Prior art date
Links
- 230000000202 analgesic effect Effects 0.000 title abstract 6
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000013268 sustained release Methods 0.000 title 1
- 239000012730 sustained-release form Substances 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 2
- PLIKAWJENQZMHA-UHFFFAOYSA-N 4-aminophenol Chemical class NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- QZNJPJDUBTYMRS-UHFFFAOYSA-M amfenac sodium hydrate Chemical compound O.[Na+].NC1=C(CC([O-])=O)C=CC=C1C(=O)C1=CC=CC=C1 QZNJPJDUBTYMRS-UHFFFAOYSA-M 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940124599 anti-inflammatory drug Drugs 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
- 235000019260 propionic acid Nutrition 0.000 abstract 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 abstract 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 abstract 1
- 229960001860 salicylate Drugs 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29555601P | 2001-06-05 | 2001-06-05 | |
| PCT/US2002/017613 WO2002098427A2 (en) | 2001-06-05 | 2002-06-05 | Sustained-release analgesic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ529661A true NZ529661A (en) | 2006-03-31 |
Family
ID=23138201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ529661A NZ529661A (en) | 2001-06-05 | 2002-06-05 | Sustained-release analgesic compounds |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20030022876A1 (enExample) |
| EP (2) | EP1399161B1 (enExample) |
| JP (2) | JP4814486B2 (enExample) |
| KR (1) | KR20040014544A (enExample) |
| CN (1) | CN1514729B (enExample) |
| AR (1) | AR034362A1 (enExample) |
| AT (1) | ATE506064T1 (enExample) |
| AU (1) | AU2002305816B2 (enExample) |
| BR (1) | BR0210179A (enExample) |
| CA (1) | CA2448665C (enExample) |
| DE (1) | DE60239801D1 (enExample) |
| IL (1) | IL158882A0 (enExample) |
| NZ (1) | NZ529661A (enExample) |
| TW (1) | TWI255186B (enExample) |
| WO (1) | WO2002098427A2 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040022853A1 (en) * | 2001-04-26 | 2004-02-05 | Control Delivery Systems, Inc. | Polymer-based, sustained release drug delivery system |
| MXPA03009727A (es) * | 2001-04-26 | 2004-01-29 | Control Delivery Sys Inc | SISTEMA DE SUMINISTRO DE FaRMACOS DE LIBERACIoN PROLONGADA QUE CONTIENE COFARMACOS. |
| IN2014DN10834A (enExample) * | 2001-09-17 | 2015-09-04 | Psivida Inc | |
| TW200500067A (en) * | 2003-01-21 | 2005-01-01 | Control Delivery Sys Inc | Salts of codrugs and uses related thereto |
| EP1603597B1 (en) * | 2003-03-13 | 2010-01-06 | Controlled Chemicals, Inc. | Oxycodone conjugates with lower abuse potential and extended duration of action |
| EP1633403A2 (en) * | 2003-05-21 | 2006-03-15 | Control Delivery Systems, Inc. | Codrugs of diclofenac |
| TWI483944B (zh) * | 2004-03-30 | 2015-05-11 | Euro Celtique Sa | 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
| US20060105941A1 (en) * | 2004-11-12 | 2006-05-18 | Allergan, Inc. | Mixed antibiotic codrugs |
| CA2593165A1 (en) * | 2005-01-05 | 2006-07-13 | Regents Of The University Of Minnesota | Analgesic conjugates |
| US20060281775A1 (en) | 2005-06-14 | 2006-12-14 | Applied Pharmacy Services, Inc. | Two-component pharmaceutical composition for the treatment of pain |
| EP1829878A1 (de) * | 2006-03-02 | 2007-09-05 | Universitätsklinikum Freiburg | Neue Morphinverbindungen für pharmazeutische Zusammensetzungen |
| US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
| US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
| US20090082314A1 (en) * | 2007-06-29 | 2009-03-26 | The Provost Fellows And Scholars Of The College Of The | Targeting Prodrugs for the Treatment of Gastrointestinal Diseases |
| EP2067858A1 (en) | 2007-12-07 | 2009-06-10 | Universidad de Sevilla | Animal models for neurodegenerative diseases |
| BRPI0912326A2 (pt) | 2008-05-20 | 2015-10-06 | Neurogesx Inc | análogos de acetaminofeno hidrossolúveis |
| CA2724881C (en) | 2008-05-20 | 2016-09-27 | Neurogesx, Inc. | Carbonate prodrugs and methods of using the same |
| EP2285419A4 (en) | 2008-05-20 | 2012-05-02 | Neurogesx Inc | LUBRICANT MUTUAL PARACETAMOL PRODRUGS |
| US20110237614A1 (en) * | 2008-09-16 | 2011-09-29 | Nektar Therapeutics | Pegylated Opioids with Low Potential for Abuse |
| WO2010042759A2 (en) | 2008-10-08 | 2010-04-15 | Kyphia Pharmaceuticals Inc | Gaba conjugates and methods of use thereof |
| FR2939436B1 (fr) * | 2008-12-10 | 2010-12-17 | Sanofi Aventis | Synthese de morphine-6-glucuronide ou de l'un de ses derives |
| EP2448408A4 (en) | 2009-07-02 | 2015-06-03 | Kempharm Inc | CONJUGATES OF PHENYLETHANOIC ACID, PHENYLPROPANOIC ACID AND PHENYLPROPENOIC ACID AND HYDROCODONE PRODRUGS, METHODS OF MAKING AND USING THEM |
| UA102916C2 (uk) | 2009-07-02 | 2013-08-27 | Кемфарм, Інк. | Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань |
| US10849981B2 (en) | 2009-07-02 | 2020-12-01 | KemPham, Inc. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof |
| JP5769889B2 (ja) | 2011-10-26 | 2015-08-26 | ケムファーム・インコーポレーテッド | ヒドロモルホンの安息香酸、安息香酸誘導体及びヘテロアリールカルボン酸結合体、そのプロドラッグ、製造法及び使用 |
| US9295731B2 (en) * | 2013-04-01 | 2016-03-29 | Mark Quang Nguyen | Cleavable drug conjugates, compositions thereof and methods of use |
| KR101616998B1 (ko) * | 2014-03-18 | 2016-04-29 | 전남대학교병원 | 오피오이드 진통제 및 p7c3를 포함하는 진통제 조성물 |
| NZ731591A (en) | 2014-11-25 | 2018-06-29 | Kempharm Inc | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone |
| NZ731586A (en) | 2014-12-02 | 2018-06-29 | Kempharm Inc | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof |
| GB201505527D0 (en) | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
| CN107033154B (zh) * | 2016-02-02 | 2020-02-04 | 上海瀚迈生物医药科技有限公司 | 阿片受体拮抗剂缀合物及其应用 |
| CN113429306A (zh) * | 2016-08-26 | 2021-09-24 | 江苏恩华药业股份有限公司 | 一种地佐辛晶型a及其制备方法 |
| WO2019071246A2 (en) | 2017-10-06 | 2019-04-11 | Foundry Therapeutics, Inc. | IMPLANTABLE DEPOSITS FOR CONTROLLED RELEASE OF ANALGESICS TO TREAT POSTOPERATIVE PAIN, AND DEVICES, SYSTEMS, AND RELATED METHODS |
| US12364792B2 (en) | 2018-01-08 | 2025-07-22 | Foundry Therapeutics, Inc. | Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents |
| WO2019221853A1 (en) | 2018-05-12 | 2019-11-21 | Foundry Therapeutics, Inc. | Implantable depots for the controlled release of therapeutic agents |
| WO2020012248A1 (en) * | 2018-07-13 | 2020-01-16 | Alkermes Pharma Ireland Limited | Novel naphthylenyl compounds for long-acting injectable compositions and related methods |
| US10807995B2 (en) | 2018-07-13 | 2020-10-20 | Alkermes Pharma Ireland Limited | Thienothiophene compounds for long-acting injectable compositions and related methods |
| WO2020047013A1 (en) | 2018-08-28 | 2020-03-05 | Foundry Therapeutics, Inc. | Polymer implants |
| CN109096191B (zh) * | 2018-10-25 | 2022-03-08 | 西北工业大学 | 氟比洛芬美普他酚酯药用化合物及其制备方法 |
| WO2020094634A1 (en) | 2018-11-05 | 2020-05-14 | Alkermes Pharma Ireland Limited | Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods |
| KR102665346B1 (ko) * | 2022-01-04 | 2024-05-13 | 한국생명공학연구원 | 신규한 디클로로페녹시아세트산 유도체 및 이의 용도 |
| CN117567477A (zh) * | 2023-11-15 | 2024-02-20 | 宜昌人福药业有限责任公司 | 一种氢吗啡酮和二氢吗啡类药物低分子聚乙二醇化物及其制备方法和应用 |
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| US2999102A (en) * | 1959-10-14 | 1961-09-05 | Thomae Gmbh Dr K | Bis-(steroid-21)-dicarboxylic acid esters |
| US3147183A (en) * | 1962-04-16 | 1964-09-01 | Boehringer Sohn Ingelheim | Bis-(steroid-21)-dicarboxylic acid esters |
| FR2576213B1 (fr) * | 1985-01-21 | 1989-02-24 | Cortial | Nouveau procede d'obtention de formes pharmaceutiques a liberation prolongee |
| JPH0232027A (ja) * | 1988-07-19 | 1990-02-01 | Rooman Kogyo:Kk | 鎮痛剤 |
| TW225536B (enExample) * | 1990-08-23 | 1994-06-21 | Ciba Geigy Ag | |
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| SE9003665D0 (sv) * | 1990-11-16 | 1990-11-16 | Kabivitrum Ab | Morphine prodrugs |
| GB9116909D0 (en) * | 1991-08-06 | 1991-09-18 | Salford Ultrafine Chem & Res | Morphine derivatives |
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| DE69426629T2 (de) * | 1993-08-02 | 2001-08-02 | Commonwealth Scientific And Industrial Research Organisation, Campbell | Therapeutische verbindung - fettsäurekonjugate |
| US6051576A (en) * | 1994-01-28 | 2000-04-18 | University Of Kentucky Research Foundation | Means to achieve sustained release of synergistic drugs by conjugation |
| JPH11502509A (ja) * | 1995-01-16 | 1999-03-02 | コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション | 治療用化合物 − 脂肪酸抱合体 |
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| US5840731A (en) * | 1995-08-02 | 1998-11-24 | Virginia Commonwealth University | Pain-alleviating drug composition and method for alleviating pain |
| DE19607395C2 (de) * | 1996-02-28 | 2002-11-21 | Lohmann Therapie Syst Lts | Salze aus einem kationischen narkotischen Analgetikum mit einem anionischen nichtnarkotischen Analgetikum, Verfahren zu deren Herstellung und die diese Salze enthaltenden pharmazeutischen Präparate |
| WO1998017673A1 (en) * | 1996-10-21 | 1998-04-30 | Cal International Limited | Isosorbide aspirinate esters |
| US6225321B1 (en) * | 1997-06-05 | 2001-05-01 | Oliver Yoa-Pu Hu | Long analgesic acting nalbuphine polyester derivative and method of use |
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| US6306842B1 (en) * | 2000-06-02 | 2001-10-23 | Medinox, Inc. | Protected forms of a combination of pharmacologically active agents and uses therefor |
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| CA2472188C (en) * | 2002-01-18 | 2011-06-21 | Control Delivery Systems, Inc. | Polymeric gel system for the controlled delivery of codrugs |
-
2002
- 2002-06-05 IL IL15888202A patent/IL158882A0/xx unknown
- 2002-06-05 NZ NZ529661A patent/NZ529661A/xx not_active IP Right Cessation
- 2002-06-05 AU AU2002305816A patent/AU2002305816B2/en not_active Ceased
- 2002-06-05 BR BR0210179-3A patent/BR0210179A/pt not_active Application Discontinuation
- 2002-06-05 CN CN028114205A patent/CN1514729B/zh not_active Expired - Fee Related
- 2002-06-05 AR ARP020102088A patent/AR034362A1/es unknown
- 2002-06-05 KR KR10-2003-7015769A patent/KR20040014544A/ko not_active Withdrawn
- 2002-06-05 TW TW091112133A patent/TWI255186B/zh not_active IP Right Cessation
- 2002-06-05 EP EP02734669A patent/EP1399161B1/en not_active Expired - Lifetime
- 2002-06-05 EP EP06006592A patent/EP1709957A3/en not_active Ceased
- 2002-06-05 CA CA2448665A patent/CA2448665C/en not_active Expired - Fee Related
- 2002-06-05 AT AT02734669T patent/ATE506064T1/de not_active IP Right Cessation
- 2002-06-05 JP JP2003501466A patent/JP4814486B2/ja not_active Expired - Fee Related
- 2002-06-05 DE DE60239801T patent/DE60239801D1/de not_active Expired - Lifetime
- 2002-06-05 WO PCT/US2002/017613 patent/WO2002098427A2/en not_active Ceased
- 2002-06-05 US US10/162,216 patent/US20030022876A1/en not_active Abandoned
-
2010
- 2010-04-08 JP JP2010089721A patent/JP2010155869A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1709957A3 (en) | 2007-02-14 |
| IL158882A0 (en) | 2004-05-12 |
| CN1514729A (zh) | 2004-07-21 |
| TWI255186B (en) | 2006-05-21 |
| CA2448665C (en) | 2013-01-29 |
| CA2448665A1 (en) | 2002-12-12 |
| EP1399161B1 (en) | 2011-04-20 |
| AR034362A1 (es) | 2004-02-18 |
| WO2002098427A2 (en) | 2002-12-12 |
| ATE506064T1 (de) | 2011-05-15 |
| EP1709957A2 (en) | 2006-10-11 |
| JP2010155869A (ja) | 2010-07-15 |
| CN1514729B (zh) | 2012-09-05 |
| DE60239801D1 (de) | 2011-06-01 |
| KR20040014544A (ko) | 2004-02-14 |
| AU2002305816B2 (en) | 2008-04-10 |
| US20030022876A1 (en) | 2003-01-30 |
| JP2004536811A (ja) | 2004-12-09 |
| WO2002098427A3 (en) | 2003-02-20 |
| BR0210179A (pt) | 2004-04-27 |
| EP1399161A2 (en) | 2004-03-24 |
| JP4814486B2 (ja) | 2011-11-16 |
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