MXPA05006889A - Compuestos aromaticos como agentes anti-inflamatorios, inmunomoduladores y anti-proliferativos. - Google Patents

Compuestos aromaticos como agentes anti-inflamatorios, inmunomoduladores y anti-proliferativos.

Info

Publication number
MXPA05006889A
MXPA05006889A MXPA05006889A MXPA05006889A MXPA05006889A MX PA05006889 A MXPA05006889 A MX PA05006889A MX PA05006889 A MXPA05006889 A MX PA05006889A MX PA05006889 A MXPA05006889 A MX PA05006889A MX PA05006889 A MXPA05006889 A MX PA05006889A
Authority
MX
Mexico
Prior art keywords
immunomodulatory
inflammatory
aromatic compounds
proliferatory
agents
Prior art date
Application number
MXPA05006889A
Other languages
English (en)
Inventor
Stefan Tasler
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Publication of MXPA05006889A publication Critical patent/MXPA05006889A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

La presente invencion se relaciona con compuestos de la formula (II) y sales y derivados fisiologicamente funcionales de los mismos (ver formula), para el uso como un medicamento.
MXPA05006889A 2002-12-23 2003-12-17 Compuestos aromaticos como agentes anti-inflamatorios, inmunomoduladores y anti-proliferativos. MXPA05006889A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10260800 2002-12-23
PCT/EP2003/014433 WO2004056797A1 (en) 2002-12-23 2003-12-17 Aromatic compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents

Publications (1)

Publication Number Publication Date
MXPA05006889A true MXPA05006889A (es) 2006-04-07

Family

ID=32667540

Family Applications (2)

Application Number Title Priority Date Filing Date
MXPA05006890A MXPA05006890A (es) 2002-12-23 2003-12-17 Compuestos como agentes anti-inflamatorios, inmunomoduladores y anti-proliferativos.
MXPA05006889A MXPA05006889A (es) 2002-12-23 2003-12-17 Compuestos aromaticos como agentes anti-inflamatorios, inmunomoduladores y anti-proliferativos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MXPA05006890A MXPA05006890A (es) 2002-12-23 2003-12-17 Compuestos como agentes anti-inflamatorios, inmunomoduladores y anti-proliferativos.

Country Status (22)

Country Link
EP (3) EP2283898A1 (es)
JP (3) JP2006514023A (es)
KR (1) KR101107456B1 (es)
CN (3) CN1939896A (es)
AT (2) ATE450498T1 (es)
AU (2) AU2003299316A1 (es)
BR (2) BR0317687A (es)
CA (2) CA2509138A1 (es)
CY (1) CY1111851T1 (es)
DE (1) DE60330391D1 (es)
DK (1) DK1578741T3 (es)
ES (1) ES2368735T3 (es)
IL (2) IL169184A (es)
MX (2) MXPA05006890A (es)
NO (2) NO20052907L (es)
NZ (1) NZ541382A (es)
PL (2) PL377478A1 (es)
PT (1) PT1578741E (es)
RU (2) RU2386625C2 (es)
SI (1) SI1578741T1 (es)
WO (1) WO2004056797A1 (es)
ZA (1) ZA200504387B (es)

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TWI530286B (zh) * 2009-05-04 2016-04-21 帕納特斯製藥格斯有限公司 作為抑制病毒化合物之抗發炎劑
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WO2012109329A2 (en) 2011-02-08 2012-08-16 Children's Medical Center Corporation Methods for treatment of melanoma
RU2485112C1 (ru) * 2012-04-26 2013-06-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" 4-(4-бромфенил)-4-оксо-2-{[3-(этоксикарбонил)-4,5-диметилтиен-2-ил]амино}-2-бутеновая кислота, обладающая противовоспалительной и анальгетической активностью
JP6271806B2 (ja) * 2014-04-11 2018-01-31 パノプテス・ファーマ・ゲーエムベーハー ウイルス静止化合物としての抗炎症剤
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NO20052908D0 (no) 2005-06-15
MXPA05006890A (es) 2006-04-07
ZA200504387B (en) 2006-02-22
IL169257A0 (en) 2007-07-04
EP1578741B1 (en) 2011-07-13
ATE450498T1 (de) 2009-12-15
IL169257A (en) 2012-02-29
AU2003293914A1 (en) 2004-07-14
BR0317731A (pt) 2005-11-22
DE60330391D1 (de) 2010-01-14
PL377467A1 (pl) 2006-02-06
CN1939896A (zh) 2007-04-04
AU2003293914B2 (en) 2010-09-23
IL169184A0 (en) 2009-02-11
NO20052907L (no) 2005-09-12
NO20052908L (no) 2005-09-12
RU2386625C2 (ru) 2010-04-20
RU2005123402A (ru) 2006-01-20
EP2283898A1 (en) 2011-02-16
RU2005123401A (ru) 2006-01-20
AU2003299316A1 (en) 2004-07-14
EP1581477B1 (en) 2009-12-02
EP1578741A1 (en) 2005-09-28
PT1578741E (pt) 2011-10-17
PL209303B1 (pl) 2011-08-31
JP2010215655A (ja) 2010-09-30
ES2368735T3 (es) 2011-11-21
JP2006511564A (ja) 2006-04-06
NZ541382A (en) 2009-04-30
CY1111851T1 (el) 2015-11-04
SI1578741T1 (sl) 2011-11-30
NO20052907D0 (no) 2005-06-15
NO335748B1 (no) 2015-02-02
CA2509139C (en) 2012-03-20
CA2509138A1 (en) 2004-07-08
JP2006514023A (ja) 2006-04-27
IL169184A (en) 2012-08-30
CN1732163B (zh) 2012-07-18
BR0317687A (pt) 2005-11-22
WO2004056797A1 (en) 2004-07-08
DK1578741T3 (da) 2011-09-26
CN1732147A (zh) 2006-02-08
KR20050089843A (ko) 2005-09-08
KR101107456B1 (ko) 2012-01-19
PL377478A1 (pl) 2006-02-06
RU2367650C2 (ru) 2009-09-20
EP1581477A1 (en) 2005-10-05
CA2509139A1 (en) 2004-07-08
CN1732163A (zh) 2006-02-08
ATE516284T1 (de) 2011-07-15
JP5300789B2 (ja) 2013-09-25

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