BR0317731A - Compostos de ácido cicloalqueno dicarboxìlicos como agentes antiinflamatórios, imunomoduladores e antiproliferativos - Google Patents

Compostos de ácido cicloalqueno dicarboxìlicos como agentes antiinflamatórios, imunomoduladores e antiproliferativos

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Publication number
BR0317731A
BR0317731A BR0317731-9A BR0317731A BR0317731A BR 0317731 A BR0317731 A BR 0317731A BR 0317731 A BR0317731 A BR 0317731A BR 0317731 A BR0317731 A BR 0317731A
Authority
BR
Brazil
Prior art keywords
immunomodulatory
antiinflammatory
dicarboxylic acid
antiproliferative agents
cycloalkene compounds
Prior art date
Application number
BR0317731-9A
Other languages
English (en)
Inventor
Johann Leban
Martin Kralik
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Priority claimed from PCT/EP2003/014434 external-priority patent/WO2004056746A1/en
Publication of BR0317731A publication Critical patent/BR0317731A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

"COMPOSTOS DE áCIDO CICLOALQUENO DICARBOXìLTCOS COMO AGENTES ANTIINFLAMATóRIOS, IMUNOMODULADOPES E ANTIPROLIFERATIVOS". A presente invenção se refere a compostos de fórmula geral (I) : e sais e derivados fisiologicamente funcionais do mesmo, onde A é um sistema de anel não-aromático contendo de 4 a 8 átomos de carbono, em que o sistema de anel compreende pelo menos uma dupla ligação e em que um ou mais dos átomos de carbono no anel podem ser substituídos por um grupo X, onde 4 X é selecionado dentre S, 0, N, NR¬ 4¬ SO, CO OU S0~ 2~; D é 0, S, SO~ 2~, NR¬ 4¬ou CH~ 2~; Z¬ 1¬ e Z¬ 2¬ são independentemente entre si 0, S, ou NR¬ 5¬; R~ 2~ é H, OR¬ 6¬ ou NHR¬ 7¬; 'E' representa um grupo alquila ou- cicloalquila ou um sistema de anel monocíclico ou policíclico substituído ou não-substituído, que pode conter um ou mais grupos X e que contém pelo menos um anel aromático; 'Y' representa hidrogênio, halogênio, haloalquila, haloalquilóxi, alquila, cicloalquila, ou um sistema de anel monocíclico ou policíclico substituído ou não-substituído, para uso como medicamento.
BR0317731-9A 2002-12-23 2003-12-17 Compostos de ácido cicloalqueno dicarboxìlicos como agentes antiinflamatórios, imunomoduladores e antiproliferativos BR0317731A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10260800 2002-12-23
PCT/EP2003/014434 WO2004056746A1 (en) 2002-12-23 2003-12-17 Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents

Publications (1)

Publication Number Publication Date
BR0317731A true BR0317731A (pt) 2005-11-22

Family

ID=32667540

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0317731-9A BR0317731A (pt) 2002-12-23 2003-12-17 Compostos de ácido cicloalqueno dicarboxìlicos como agentes antiinflamatórios, imunomoduladores e antiproliferativos
BR0317687-8A BR0317687A (pt) 2002-12-23 2003-12-17 Compostos aromáticos como agentes antiinflamatórios, imunomoduladores e antiproliferativos

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR0317687-8A BR0317687A (pt) 2002-12-23 2003-12-17 Compostos aromáticos como agentes antiinflamatórios, imunomoduladores e antiproliferativos

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EP (3) EP1578741B1 (pt)
JP (3) JP2006511564A (pt)
KR (1) KR101107456B1 (pt)
CN (3) CN1732163B (pt)
AT (2) ATE450498T1 (pt)
AU (2) AU2003293914B2 (pt)
BR (2) BR0317731A (pt)
CA (2) CA2509138A1 (pt)
CY (1) CY1111851T1 (pt)
DE (1) DE60330391D1 (pt)
DK (1) DK1578741T3 (pt)
ES (1) ES2368735T3 (pt)
IL (2) IL169184A (pt)
MX (2) MXPA05006890A (pt)
NO (2) NO20052907L (pt)
NZ (1) NZ541382A (pt)
PL (2) PL377478A1 (pt)
PT (1) PT1578741E (pt)
RU (2) RU2367650C2 (pt)
SI (1) SI1578741T1 (pt)
WO (1) WO2004056797A1 (pt)
ZA (1) ZA200504387B (pt)

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NO20052907L (no) 2005-09-12
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IL169184A0 (en) 2009-02-11
CN1939896A (zh) 2007-04-04
NO335748B1 (no) 2015-02-02
EP1581477B1 (en) 2009-12-02
JP5300789B2 (ja) 2013-09-25
CN1732163B (zh) 2012-07-18
SI1578741T1 (sl) 2011-11-30
AU2003293914A1 (en) 2004-07-14
EP2283898A1 (en) 2011-02-16
EP1578741A1 (en) 2005-09-28
MXPA05006890A (es) 2006-04-07
NO20052908D0 (no) 2005-06-15
KR20050089843A (ko) 2005-09-08
CN1732147A (zh) 2006-02-08
ZA200504387B (en) 2006-02-22
CY1111851T1 (el) 2015-11-04
RU2367650C2 (ru) 2009-09-20
RU2005123402A (ru) 2006-01-20
AU2003299316A1 (en) 2004-07-14
KR101107456B1 (ko) 2012-01-19
NO20052907D0 (no) 2005-06-15
PL377467A1 (pl) 2006-02-06
ATE450498T1 (de) 2009-12-15
CA2509138A1 (en) 2004-07-08
PL209303B1 (pl) 2011-08-31
ES2368735T3 (es) 2011-11-21
CA2509139A1 (en) 2004-07-08
IL169257A (en) 2012-02-29
EP1578741B1 (en) 2011-07-13
DE60330391D1 (de) 2010-01-14
IL169184A (en) 2012-08-30
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CN1732163A (zh) 2006-02-08
WO2004056797A1 (en) 2004-07-08
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JP2006514023A (ja) 2006-04-27
ATE516284T1 (de) 2011-07-15

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